Hub : Genes

CRISPLD2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Atrial Appendage 0.2500 0.0880 7.9e-03 -0.006 NA 0.063 NA 0.006 7.1e-01 NA 8.2e-04 NA 1.7e-01
2 NTR Blood 0.1042 0.0211 2.3e-08 0.051 0.034 0.069 0.075 0.072 4.8e-16 4.5e-11 3.1e-21 3.5e-23 4.6e-22
3 YFS Blood 0.3925 0.0311 0.0e+00 0.186 0.226 0.307 0.315 0.305 1.8e-58 2.3e-72 1.0e-102 6.9e-106 4.7e-102
4 TCGA Colon Adenocarcinoma 0.2380 0.0570 2.8e-06 0.230 0.132 0.200 NA 0.219 1.7e-13 4.9e-08 9.4e-12 NA 7.6e-13
5 TCGA Kidney Renal Clear Cell Carcinoma 0.1315 0.0365 1.3e-06 0.090 0.069 0.083 NA 0.082 2.6e-10 3.0e-08 1.2e-09 NA 1.5e-09
6 TCGA Lung Adenocarcinoma 0.0835 0.0312 1.3e-03 0.023 0.021 0.012 NA 0.020 8.2e-04 1.5e-03 1.2e-02 NA 2.0e-03
7 TCGA Lung Squamous Cell Carcinoma 0.1104 0.0353 1.0e-04 0.056 0.037 0.057 NA 0.048 6.2e-07 4.5e-05 4.4e-07 NA 3.6e-06
8 TCGA Prostate Adenocarcinoma 0.0831 0.0327 3.1e-03 -0.002 0.011 -0.002 NA -0.001 5.4e-01 2.2e-02 7.4e-01 NA 4.1e-01
9 TCGA Stomach Adenocarcinoma 0.1230 0.0490 4.1e-03 0.075 0.028 0.029 NA 0.053 4.0e-06 3.7e-03 3.3e-03 NA 1.0e-04
10 TCGA Thyroid Carcinoma 0.0760 0.0290 1.0e-03 -0.003 0.004 0.001 NA 0.004 9.7e-01 1.3e-01 2.4e-01 NA 1.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.4 0.6 1.5 -1.2 -0.1 -0.3 0.4 1.2 1.1 0.7 0.2 0.3 0.9
Bipolar Disorder or Schizophrenia 0.4 0.9 4.3 -2.1 -0.7 -1.1 0.8 1.0 0.2 0.6 -0.3 0.7 0.6
Depressed Affect (Nagel 2018) 0.2 0.5 1.4 -0.5 0.3 1.2 -0.4 1.1 0.9 0.0 0.8 0.1 -0.1
Depression (Nagel 2018) 0.3 0.5 2.6 -0.1 1.1 1.6 -0.8 -0.1 -0.2 -0.4 0.1 -0.6 -0.0
Intelligence (Savage-Jansen 2018) 0.3 0.8 3.6 0.4 -0.9 -1.9 0.1 1.6 -0.1 -0.1 -0.1 0.0 0.9
Neuroticism (Nagel 2018) 0.5 1.1 2.7 -0.6 0.4 1.4 0.5 1.6 1.6 0.6 1.5 0.9 -0.6
Schizophrenia (2018) 0.3 0.7 3.6 -1.9 -0.8 -1.2 0.6 0.3 -0.4 0.4 -0.6 0.7 -0.0
Schizophrenia vs Biploar Disorder 0.7 1.0 1.7 0.5 0.6 1.1 -1.2 -1.1 -0.8 -1.3 0.3 -1.1 -1.2
Worry (Nagel 2018) 0.7 1.5 3.4 -0.3 0.7 1.7 0.9 1.6 1.6 0.8 1.8 1.0 -1.1
Alzheimer’s Disease (in mother) 0.5 0.6 1.7 -0.4 -0.8 -1.3 -0.1 -0.3 -1.3 -0.7 0.1 -0.3 -0.8
Alzheimer’s Disease (in father) 0.9 1.0 2.8 0.5 1.2 1.6 -0.6 -0.2 -1.0 -0.8 -0.8 -0.7 -1.7
Alzheimer’s Disease (including proxy) 0.5 0.7 2.2 -0.4 0.1 0.4 -0.6 -0.6 -1.3 -1.1 -0.3 -0.9 -1.5
Crohns Disease (2017) 0.6 1.4 4.1 -1.5 2.0 2.0 -0.9 -0.4 -0.5 -1.1 0.6 -0.7 -0.7
Irritable Bowel Disease (IBD) 0.4 0.9 2.6 0.2 0.1 0.0 1.2 0.8 1.6 1.0 1.3 1.3 0.4
Ulcerative Colitis (UC) 2.5 4.6 8.2 1.8 -1.9 -1.9 2.6 2.1 2.9 2.2 1.9 2.6 0.8
Major Depression (MDD) 0.1 0.2 0.5 -0.7 0.4 0.7 0.0 0.0 0.5 0.0 0.3 0.0 0.6
Reaction Time 0.8 1.5 4.3 -0.5 -0.3 -0.6 -1.0 -1.2 -1.6 -1.6 -1.0 -1.1 -2.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.8 0.6 -0.5 -1.2 0.1 0.7 0.3 0.4 0.9 0.2 1.3
Breast Cancer 0.1 0.2 0.8 -0.9 -0.1 -0.8 -0.3 -0.4 -0.1 -0.5 -0.4 -0.2 0.3
Ovarian Cancer 0.4 0.5 3.4 -0.2 0.1 0.3 0.6 0.2 0.5 1.0 -1.8 0.4 0.1
Prostate Cancer 0.2 0.3 1.4 0.3 -0.9 -1.2 -0.0 -0.1 -0.2 0.1 -1.0 0.0 -0.4
Age at First Birth 0.7 1.0 4.9 -0.6 0.0 0.3 1.2 2.2 0.9 0.8 0.6 1.2 0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.4 -0.1 -0.1 -0.2 -0.3 -1.2 -1.0 -0.3 -0.7 -0.3 0.8
Coronary Artery Disease (CAD) 3.8 4.5 8.6 -1.1 0.5 1.0 -2.9 -2.5 -2.8 -2.5 0.0 -2.8 -2.4
Crohns Disease (2012) 1.0 1.6 3.3 -1.4 1.8 1.6 -1.4 -1.3 -0.7 -1.2 -0.6 -1.3 -0.4
Mean Putamen Volume 0.3 0.3 1.3 -0.1 0.6 1.1 0.6 0.1 -0.1 0.3 0.3 0.7 -0.3
Fasting Glucose 0.4 0.5 1.4 0.4 0.0 -0.0 0.8 1.2 1.1 0.9 0.4 0.6 0.7
HbA1C 0.4 0.5 1.4 0.5 0.6 0.4 -0.7 -0.4 -0.5 -0.8 -1.2 -1.0 0.3
HDL Cholesterol 0.3 0.5 1.8 0.2 -0.1 -0.6 1.1 1.3 0.1 0.2 0.2 1.2 -0.3
LDL Cholesterol 0.5 0.8 3.5 0.9 -0.7 -1.0 -0.6 -1.1 0.0 -0.0 -0.6 -0.6 1.9
Lupus 1.1 1.7 4.2 1.8 -1.1 -1.5 1.1 2.0 0.9 0.8 1.4 1.0 0.8
Neuroticism (2016) 0.4 0.5 4.0 0.3 -0.1 -0.3 -0.4 0.6 0.2 0.4 2.0 -0.3 -0.2
Primary Biliary Cirrhosis 2.0 2.8 11.0 -1.3 1.2 1.0 -0.7 -0.5 -1.8 -2.3 -1.7 -0.7 -3.3
Rheumatoid Arthritis 0.2 0.3 1.2 1.1 -0.5 -0.9 -0.3 0.1 0.4 -0.1 0.3 -0.3 0.6
Schizophrenia (2014) 0.1 0.2 0.6 -0.8 0.4 0.0 0.2 0.5 0.3 -0.2 -0.5 0.1 -0.1
Triglycerides 0.4 0.6 2.5 0.3 -0.8 -1.1 -0.3 -0.2 0.6 0.4 -1.0 -0.4 1.6
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.9 -0.2 1.4 1.2 -0.1 0.5 -1.0 -0.1 -0.4 0.1 -0.4
Ulcerative Colitis 0.5 0.8 1.6 0.6 -0.7 -1.1 1.2 0.5 1.3 0.8 -0.2 1.3 0.5
Blood Eosinophil Count 0.2 1.7 4.6 0.3 -0.5 -0.8 1.0 1.3 2.1 1.1 2.1 1.0 1.6
Blood Platelet Count 0.1 1.1 2.8 0.9 1.0 0.7 -1.6 -1.3 0.5 -0.9 -0.7 -1.7 -0.3
Blood Red Count 0.2 1.7 7.3 1.4 -0.8 -0.8 -1.2 -2.7 -1.2 -1.2 0.4 -1.2 -0.8
Blood White Count 0.2 1.5 4.7 0.1 0.0 -0.8 -2.2 -1.6 0.3 -1.5 0.7 -1.9 0.1
Heel T-Score 0.2 1.3 3.9 1.0 -0.1 -0.0 -0.6 -1.9 -1.6 0.1 -2.0 -0.7 0.7
BMI 0.4 2.4 5.2 2.3 -1.5 -1.4 1.7 1.1 1.2 2.0 0.4 1.7 1.5
Height 0.7 13.2 36.1 -0.5 -0.3 -2.0 5.8 6.0 1.9 2.8 -3.7 5.7 -0.4
Waist Hip Ratio (WHR) 0.8 3.5 17.6 0.9 0.3 -0.1 -0.2 -2.0 -2.1 -1.5 -4.2 -0.2 -2.5
Systolic Blood Pressure 0.7 3.3 9.2 3.0 -1.9 -2.1 1.9 1.5 2.1 1.5 0.3 1.8 0.1
Smoking Status 0.6 1.4 6.9 -0.4 -1.4 -2.6 0.8 0.6 1.4 0.8 0.3 0.8 0.7
Allergy or Eczema 0.8 2.2 5.8 1.4 -1.8 -1.5 2.4 0.4 0.6 1.4 0.6 2.4 0.3
Cardiovascular Disease 0.6 1.8 5.4 2.3 -0.8 -0.3 1.7 1.9 1.3 1.0 0.1 1.7 0.8
Hypothyroidism (self reported) 0.2 0.6 2.8 0.3 0.6 0.2 0.5 1.7 -0.1 0.9 -0.4 0.5 0.8
Respiratory disease 0.9 1.9 6.0 -0.3 1.2 0.9 -1.7 -0.7 -1.2 -2.0 0.3 -1.5 -2.4
Type 2 Diabetes (T2D) (2018) 0.4 0.8 3.7 -0.4 0.1 -0.9 -0.5 -1.3 -0.9 -0.2 -1.9 -0.4 -1.0
Lung FEV1/FVC ratio 0.1 0.7 1.8 0.2 -1.3 -0.9 -0.5 -1.1 -0.6 -1.0 -0.2 -0.7 0.9
Lung FVC 0.9 4.8 15.4 0.6 -1.7 -1.4 1.8 3.9 2.8 1.9 3.0 1.8 1.1
Neuroticism 0.8 1.9 6.0 -1.1 -0.4 0.1 0.6 2.4 2.1 0.6 2.4 0.8 -0.3
Chronotype (morning person) 1.3 3.0 5.4 -0.5 1.8 2.3 -1.6 -2.2 -1.9 -1.6 -0.8 -1.6 -2.0
Hair Pigment 0.1 1.5 6.7 2.6 -0.8 -0.5 -0.2 -0.6 -1.9 -0.5 0.5 -0.3 -1.6
Tanning 0.1 1.1 3.0 -1.7 0.7 0.8 -1.3 -0.0 1.5 -1.2 -0.6 -1.2 0.2
Hand grip strength (left) 0.7 1.9 5.0 -0.7 2.1 1.8 0.0 -0.8 -2.1 -0.4 -2.2 -0.3 -1.0
Number of treatments/medications taken 0.4 0.6 2.7 0.5 -1.1 -0.0 0.5 0.6 0.9 0.6 1.6 0.5 0.4
Average weekly spirits intake 1.2 1.5 4.1 -1.1 -0.0 -0.1 0.9 2.0 1.8 1.4 0.7 1.1 1.5
Sensitivity / hurt feelings 0.8 1.3 4.7 0.6 0.7 1.4 0.8 2.2 1.5 0.4 1.2 0.8 -0.6
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.2 1.0 0.6 1.1 -0.9 0.2 -0.5 -0.4 0.6 -0.7 -0.2
Hearing difficulty/problems: Yes 0.7 1.0 2.3 0.1 -1.1 -1.5 1.1 0.9 -0.2 0.2 -0.9 1.2 1.5
Relative age of first facial hair 0.5 1.0 2.3 -0.2 0.7 0.2 -1.3 -1.5 -1.1 -1.2 -1.0 -1.2 -0.6
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 5.0 0.1 2.1 2.2 -0.8 0.6 -0.2 -1.4 0.8 -0.5 -1.3
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.0 0.2 -1.4 -1.0 0.8 -1.0 -0.2 0.7 -1.1 0.8 0.7
Ever had hysterectomy (womb removed) 0.3 0.3 0.9 0.1 -0.9 -0.4 -0.2 -0.5 0.6 -0.6 0.9 -0.2 0.0
Systolic blood pressure, automated reading 0.7 1.9 5.0 2.2 -1.0 -1.5 0.8 1.5 2.2 1.3 0.6 0.8 0.8
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.1 -0.8 0.8 0.5 -0.6 -0.5 -0.7 -0.1 -1.0 -0.6 0.2
Angina 0.8 1.1 2.0 -0.8 0.5 -0.1 -1.2 -1.2 -1.2 -1.4 -1.4 -1.2 -0.5
Medication for hormone replacement therapy 2.7 3.0 6.4 -0.5 1.9 2.5 -1.8 -1.7 -1.8 -1.5 -0.3 -1.8 -2.1
Vitamin and mineral supplements 0.2 0.2 0.7 0.9 0.5 0.3 -0.0 -0.3 0.8 0.3 0.5 -0.0 0.5
Supplements: Zinc 0.6 0.6 3.9 0.3 -0.6 -0.4 0.6 1.0 0.4 -0.0 0.5 0.5 -2.0
Medication: Co-codamol 0.2 0.3 0.9 0.6 -0.3 -0.4 -0.1 -0.9 0.5 -0.3 0.1 -0.1 -0.9
Medication: Metformin 0.4 0.6 2.4 -0.4 0.5 0.3 -0.8 -0.8 -0.4 -0.7 -1.5 -0.8 -0.6
Diabetes (father) 0.3 0.3 1.5 0.2 -0.1 -0.4 -0.4 0.3 -0.4 -0.3 1.2 -0.5 -0.9
Diabetes (mother) 0.9 1.2 4.3 -0.7 0.9 0.6 -0.4 -0.3 -2.1 -1.6 -0.6 -0.2 -1.7
Severe depression (siblings) 0.6 0.7 1.6 -0.0 -0.9 -1.3 0.9 0.7 -0.7 0.9 -0.4 0.7 1.0
Pack years adult smoking proportion 0.3 0.4 1.2 1.0 -0.8 -0.4 -0.6 -0.5 -0.4 -0.2 0.6 -0.6 -1.1
Impedance of leg (right) 0.3 1.5 3.1 -0.2 1.1 1.4 1.1 1.8 1.3 0.7 -1.4 1.2 -1.4
Leg fat-free mass (left) 0.5 2.5 5.3 1.2 -1.5 -2.3 2.1 1.6 0.8 1.4 0.5 1.9 1.6
Trunk fat percentage 1.2 4.9 14.3 2.6 -0.6 -1.2 2.8 3.8 2.2 2.4 0.3 2.8 0.6
Hand grip strength (right) 0.5 1.5 6.9 -0.8 1.5 1.5 0.4 0.3 -1.3 -0.4 -2.6 -0.0 -0.7
Townsend deprivation index at recruitment 0.5 0.6 1.9 -0.5 0.3 -0.4 -1.4 0.3 0.8 -0.4 1.2 -1.2 0.3
Current tobacco smoking 1.4 2.4 8.5 0.6 -2.6 -2.9 1.1 0.5 1.2 1.0 0.3 1.1 1.7
Average weekly fortified wine intake 1.6 1.9 10.2 -1.1 0.7 -0.0 -1.2 -1.6 -1.1 -0.7 -3.2 -1.3 0.3
Maternal smoking around birth 0.3 0.5 1.8 -1.0 0.7 1.4 0.0 0.7 0.1 -0.2 -0.8 -0.1 -0.4
Fed-up feelings 0.2 0.4 1.7 -0.3 -0.2 0.5 -0.5 1.0 1.3 0.3 0.9 -0.4 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.8 -0.0 -0.0 0.3 -1.6 -0.9 -0.4 -1.2 0.0 -1.7 -0.3
Relative age voice broke 1.2 1.8 3.4 1.0 1.4 1.0 -1.7 -1.6 -1.3 -1.7 -0.6 -1.8 -0.7
Taking other prescription medications 0.3 0.4 1.7 0.1 0.1 0.8 -0.4 0.1 -0.7 -0.8 0.7 -0.3 -1.3
Age when periods started (menarche) 1.0 2.4 5.3 -1.9 1.0 1.2 -1.7 -2.3 -0.9 -1.0 1.8 -1.9 -0.8
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 4.0 1.0 -1.6 -0.7 0.1 -0.1 2.0 0.3 -0.7 0.1 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 3.0 0.0 -0.8 -0.8 0.1 -0.5 -0.6 0.5 -1.7 -0.1 0.8
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 5.2 2.3 -1.3 -1.0 0.6 1.1 1.2 0.7 1.3 0.6 0.9
Qualifications: CSEs or equivalent 0.4 0.6 1.2 -1.1 0.8 0.4 0.5 0.7 0.5 1.1 -0.9 0.5 0.5
Serious illness, injury or assault to yourself 1.2 1.4 2.6 1.4 -1.0 -0.8 1.6 0.6 1.4 1.0 1.4 1.6 0.4
High blood pressure 1.8 4.9 7.7 2.6 -0.9 -1.1 2.8 2.7 2.6 2.6 0.9 2.8 1.8
Hayfever, allergic rhinitis or eczema 0.3 0.8 2.1 0.7 -1.1 -0.8 1.5 -0.2 -0.4 0.9 0.6 1.4 0.1
Multivitamins +/- minerals 0.3 0.4 1.7 0.3 -1.3 -1.0 0.3 0.2 -0.7 0.1 -0.6 0.3 -0.5
Stomach or abdominal pain in last month 0.9 1.1 2.3 0.5 -0.5 -0.0 1.4 1.5 1.5 1.2 0.9 1.4 0.3
Supplements: Glucosamine 0.5 0.6 3.6 0.0 -0.4 -0.5 0.7 1.9 -0.5 0.5 -0.6 0.8 0.6
Diverticular disease/diverticulitis (self-reported) 7.0 8.4 18.0 2.2 -3.1 -2.3 3.2 3.1 4.2 2.8 2.1 3.2 1.6
Medication: Atenolol 0.2 0.3 1.1 0.3 -0.0 0.8 0.7 -0.3 -1.0 -0.4 0.3 0.6 -0.2
Medication: Levothyroxine sodium 0.9 1.6 5.5 -0.4 -0.5 -0.1 1.1 2.3 1.7 1.4 -0.8 1.1 1.5
Sitting height 0.3 2.2 4.5 1.7 -2.1 -1.8 1.4 0.7 1.7 1.5 1.1 1.2 1.4
Chronic bronchitis/emphysema (father) 2.6 3.0 6.2 -0.5 -1.4 -1.9 1.8 2.2 1.9 2.5 -0.2 2.0 1.5
High blood pressure (mother) 2.0 2.8 6.3 2.5 -0.7 -0.1 2.1 2.3 0.8 1.3 2.0 2.2 0.4
Body mass index (BMI) 0.4 1.7 3.4 1.9 -1.2 -1.7 1.2 0.9 1.1 1.4 0.7 1.1 1.5
Impedance of leg (left) 0.3 1.6 4.8 0.2 1.4 1.9 0.6 1.5 0.7 0.2 -1.2 0.7 -2.2
Leg predicted mass (left) 0.4 2.3 5.1 1.1 -1.4 -2.3 2.0 1.5 0.7 1.4 0.5 1.8 1.5
Trunk fat mass 1.1 4.7 13.0 2.4 -0.7 -1.5 2.8 3.6 1.9 2.4 0.1 2.7 0.8
Waist circumference 0.4 1.6 3.6 1.4 -0.7 -1.3 1.9 1.3 0.8 1.3 -0.8 1.8 0.5
Number of incorrect matches in round 0.8 1.3 3.8 -1.9 -0.3 -0.7 0.2 -0.8 -1.0 0.1 -1.8 0.2 -1.9
Past tobacco smoking 0.6 1.1 3.1 0.0 0.9 1.8 -0.8 -1.0 -1.4 -1.1 0.6 -0.7 -1.4
Alcohol usually taken with meals 0.3 0.5 3.5 1.0 0.0 0.0 -0.1 -0.4 0.2 -0.6 -1.9 -0.3 0.4
Nervous feelings 0.7 1.3 2.8 0.5 -0.4 0.1 1.3 1.7 1.3 1.3 1.6 1.4 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.0 -0.6 -0.6 -0.2 -0.6 1.4 -0.3 -0.6 0.9 -0.3 -0.8
Hearing difficulty/problems with background noise 1.0 1.6 4.2 1.0 -0.8 -1.0 1.2 2.0 0.6 1.5 -0.2 1.2 1.8
Hair/balding pattern: Pattern 2 0.4 0.5 1.7 1.3 0.6 1.2 0.4 -0.2 1.0 0.6 -0.4 0.4 0.1
Had menopause 0.3 0.4 1.6 -0.5 -0.9 -1.2 -0.2 -0.7 -0.3 -0.7 -0.3 -0.2 0.2
Had other major operations 1.0 1.2 3.8 1.5 -1.9 -1.6 0.8 0.6 0.7 0.4 0.1 0.8 1.0
Forced vital capacity (FVC) 1.1 4.4 9.2 1.0 -1.5 -1.6 3.0 3.0 1.8 2.4 1.1 2.8 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 4.7 0.2 -1.4 -2.2 1.0 0.6 1.3 1.1 -1.8 0.8 1.7
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.7 -0.3 0.5 -0.0 -0.3 0.6 -0.7 -0.4 -0.8 -0.3 -0.5
Qualifications: None of the above 0.6 1.3 6.8 -0.2 -1.2 -0.7 0.6 0.5 2.6 1.0 1.1 0.8 0.5
Financial difficulties in last 2 years 0.7 0.9 2.4 1.2 -0.7 -0.3 0.7 0.9 1.5 0.8 1.6 0.5 0.2
Mouth/teeth dental problems 1.2 1.8 5.9 -0.0 2.4 2.4 -0.7 -1.0 -1.5 -1.2 -0.2 -0.7 -0.6
Heart attack 0.2 0.2 1.3 0.1 0.3 -0.1 -0.4 0.5 1.1 -0.2 -0.5 -0.4 -0.2
Allergy 0.2 0.4 1.7 -1.3 0.5 0.3 -0.8 0.6 -0.3 -0.4 -0.7 -0.8 -0.1
Pain all over the body in last month 2.5 2.7 6.0 2.5 -1.7 -1.3 1.4 1.1 2.4 1.1 0.8 1.5 1.8
Diabetes (self-reported) 0.3 0.5 2.6 -0.1 -0.0 -0.5 -0.6 -0.8 -0.2 -0.0 -1.6 -0.7 -0.8
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.9 0.0 -1.7 -1.5 1.4 0.9 0.1 0.8 -0.8 1.5 0.2
Medication: Ramipril 0.8 1.0 3.0 0.2 0.5 0.7 1.0 1.7 1.1 1.4 -0.8 0.8 0.7
Medication: Simvastatin 0.2 0.2 0.7 0.8 -0.1 0.5 0.4 0.4 0.9 0.3 -0.5 0.4 0.1
Fluid intelligence score 0.5 1.0 3.1 0.7 -1.2 -1.5 0.5 0.6 0.6 0.2 1.3 0.5 1.8
Illnesses of siblings 1.2 1.6 3.7 -1.0 0.2 -0.2 -1.7 -1.9 -0.5 -1.6 -1.7 -1.5 0.9
Neuroticism score 0.8 1.7 8.6 -0.7 0.2 0.6 0.6 2.9 1.6 0.7 1.7 0.8 -0.3
Weight 0.8 4.0 7.5 1.9 -1.2 -2.1 2.7 2.7 1.5 2.1 -0.0 2.5 1.5
Impedance of arm (right) 0.9 4.1 14.2 1.7 0.5 0.5 2.3 3.8 2.7 2.0 0.7 2.5 -0.6
Arm fat percentage (right) 1.0 4.0 8.0 2.8 -0.7 -1.5 2.1 2.8 2.4 2.3 0.9 2.1 1.3
Trunk fat-free mass 0.1 0.6 1.8 -0.2 -0.6 -1.2 1.3 0.9 -0.2 0.4 -0.5 1.0 0.7
Hip circumference 1.4 6.0 12.4 1.2 -1.6 -2.4 3.5 3.2 1.7 3.0 0.4 3.3 2.0
Time employed in main current job 0.3 0.4 1.2 0.5 0.3 -0.0 -0.3 -0.2 0.4 -0.7 -1.1 -0.5 -1.1
Alcohol intake versus 10 years previously 0.3 0.5 0.9 -0.8 -0.9 -0.7 -0.1 -0.7 -0.7 -0.7 0.8 -0.2 -0.8
Father’s age at death 2.8 3.8 10.7 -3.3 0.4 0.1 -1.6 -2.2 -2.7 -2.1 -2.4 -1.6 0.2
Worrier / anxious feelings 0.3 0.6 2.6 -1.6 0.5 0.7 0.0 0.9 0.7 -0.1 0.4 -0.1 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 2.4 1.6 -1.0 -0.4 1.1 1.4 1.2 1.3 0.4 1.2 1.0
Falls in the last year 2.4 3.2 11.2 1.4 -1.3 -1.5 1.1 2.4 3.3 1.8 1.0 1.3 1.6
Hair/balding pattern: Pattern 3 0.4 0.6 1.2 -0.8 -0.1 -0.5 1.1 0.4 -1.0 0.3 1.0 1.0 0.0
Number of live births 0.9 1.2 4.3 1.1 -1.0 -0.4 -0.6 0.7 1.6 0.0 2.1 -0.5 1.3
Forced expiratory volume in 1-second (FEV1) 1.3 4.4 8.1 1.6 -2.0 -1.9 2.9 2.7 1.6 2.3 1.0 2.6 1.7
Pulse rate 0.9 1.5 4.5 -0.3 1.3 1.8 -1.3 -1.3 -0.8 -2.1 -0.2 -1.1 -0.3
Happiness 0.6 0.7 1.7 -0.4 -0.3 -0.3 -1.3 -1.0 -1.0 -1.0 0.2 -1.3 0.3
Noisy workplace 0.2 0.3 0.9 -0.8 -0.1 -0.5 0.4 0.4 0.3 1.0 -0.5 0.5 0.4
Qualifications: A levels/AS levels or equivalent 0.3 0.7 3.0 -1.3 0.3 -0.6 -0.2 -0.0 -1.0 -0.5 -1.7 -0.2 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.9 0.0 0.7 -0.5 0.6 0.3 0.6 0.5 1.4 0.7 0.1
Mouth/teeth dental problems: Dentures 0.4 0.7 1.8 -1.2 1.2 0.5 -0.9 0.2 0.2 -0.4 0.2 -0.9 -1.3
Asthma 0.6 1.1 2.7 0.2 0.3 0.4 -1.5 -1.2 -0.7 -1.6 0.2 -1.6 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 4.1 0.8 -1.5 -1.1 -0.1 -0.4 0.7 1.0 -1.2 -0.0 2.0
Medication: Cholesterol lowering 1.2 1.9 4.8 0.9 -0.4 -0.3 1.4 1.2 1.8 2.2 -1.2 1.4 1.9
Depression (self-reported) 1.2 1.4 4.8 -0.5 1.3 0.8 -1.2 -0.9 -2.2 -1.5 0.0 -1.0 -1.2
Medication: Lansoprazole 0.3 0.4 1.0 -0.6 -0.9 -0.8 -0.4 -0.0 1.0 -0.0 0.9 -0.4 0.2
Prospective memory result 0.8 1.0 7.3 0.4 0.4 0.5 0.6 1.0 0.5 0.2 2.7 0.6 -0.6
Lung cancer (father) 0.6 0.7 3.0 -0.4 0.5 0.7 -0.1 0.8 1.7 0.6 1.3 -0.1 0.9
Illnesses of mother 0.7 0.9 2.2 -0.4 1.5 0.9 -1.3 -0.8 0.7 0.1 -0.4 -1.2 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 5.2 1.1 -1.8 -2.0 2.1 2.3 0.6 1.6 0.9 1.9 1.0
Pulse wave Arterial Stiffness index 0.3 0.4 0.8 0.7 0.8 0.7 -0.1 0.3 -0.1 -0.7 0.9 -0.1 -0.9
Impedance of arm (left) 0.5 2.4 8.9 0.9 1.0 1.1 1.8 3.0 1.7 1.4 -0.8 1.9 -0.6
Arm fat mass (right) 1.0 4.2 6.9 2.4 -1.1 -2.0 2.5 2.6 2.0 2.2 0.7 2.4 1.5
Trunk predicted mass 0.1 0.7 1.8 -0.3 -0.6 -1.2 1.3 0.9 -0.2 0.4 -0.5 1.1 0.6
Standing height 0.5 5.2 17.2 0.3 -0.2 -1.0 3.7 4.2 1.2 1.9 -1.6 3.5 -0.1
Length of working week for main job 2.0 2.2 9.3 1.7 -0.8 -1.0 1.4 0.7 3.0 1.3 1.2 1.4 0.4
Exposure to tobacco smoke at home 0.8 0.9 2.1 0.6 1.4 1.3 -0.5 0.9 1.2 -0.3 1.5 -0.5 -0.6
Breastfed as a baby 0.5 0.7 4.6 -2.1 -0.2 -0.5 -0.2 0.1 -0.1 0.2 0.7 -0.1 -1.1
Tense / ‘highly strung’ 1.9 3.2 11.6 0.0 -0.2 -0.0 2.0 3.4 1.7 2.1 1.9 2.1 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 2.1 -1.5 0.9 0.9 0.3 0.9 -0.5 -0.0 -0.2 0.1 -1.0
Hair/balding pattern: Pattern 4 0.1 0.3 1.7 -0.1 0.3 -0.0 -0.6 -0.4 -1.3 -0.6 0.1 -0.4 -0.1
Birth weight of first child 1.2 2.2 13.0 1.4 0.2 -0.4 1.3 3.6 1.6 1.1 0.6 1.2 0.3
Peak expiratory flow (PEF) 0.4 0.9 2.7 1.6 -1.6 -0.6 0.2 -0.4 -1.5 -0.3 0.6 -0.3 0.2
Pulse wave reflection index 0.3 0.3 0.7 0.1 0.8 0.5 0.6 0.6 0.7 0.3 0.8 0.6 0.0
Ever highly irritable/argumentative for 2 days 2.3 2.8 10.2 0.7 -0.2 -0.1 1.8 1.9 3.2 2.3 0.7 1.7 1.1
Loud music exposure frequency 0.6 0.7 1.5 0.1 -1.1 -1.1 -1.2 0.1 1.2 -0.6 -0.7 -0.9 0.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 6.1 0.5 0.3 -0.1 -0.0 -0.0 -2.5 -0.8 -0.2 -0.1 -1.0
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 4.7 1.0 -2.1 -2.2 1.1 1.4 1.1 1.3 -0.0 1.2 1.2
Blood clot in the leg (DVT) 1.6 2.1 6.2 2.0 -0.5 -0.7 1.4 1.5 1.3 0.9 2.5 1.6 -0.0
Medication: Paracetamol 0.4 0.7 2.7 0.4 0.1 0.4 -1.1 -1.6 -0.0 -0.7 -0.6 -1.3 -0.5
Headache pain in last month 0.2 0.3 1.2 -0.0 -0.5 -0.6 0.6 0.3 -0.4 1.1 -0.0 0.5 0.8
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 5.8 -1.2 -0.1 -0.2 -2.1 -2.3 -2.1 -2.4 0.6 -2.1 -1.8
Glaucoma (self-reported) 2.4 2.9 7.2 0.2 0.2 0.4 -1.6 -2.7 -1.8 -2.1 -2.3 -1.5 -1.7
Gout (self-reported) 0.7 0.9 6.3 -0.9 0.0 -0.7 -0.1 -0.6 -1.1 0.2 -2.5 -0.2 0.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 6.5 -0.2 0.3 0.1 0.7 2.6 0.6 1.3 0.1 0.7 1.2
Medication: Amlodipine 0.6 0.8 2.1 1.0 1.2 0.9 0.4 0.7 1.1 0.5 1.4 0.4 -0.2
Medication: Ventolin 100micrograms inhaler 0.8 1.0 5.2 0.9 0.8 1.6 -0.0 0.5 0.0 -0.3 2.3 0.1 -0.8
Birth weight 0.5 1.1 2.5 0.5 -1.4 -1.3 1.2 1.4 1.6 0.4 0.2 1.2 0.5
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.8 0.7 -0.9 -0.5 -0.7 0.5 0.1 -0.0 -0.6 -0.7 -0.1
High blood pressure (siblings) 1.0 1.4 4.7 1.1 0.8 0.9 0.9 1.8 0.9 0.8 2.2 0.8 -0.7
Forced vital capacity (FVC), Best measure 0.7 2.7 7.5 0.6 -1.4 -1.7 2.3 2.7 1.1 1.8 0.7 2.1 0.6
Body fat percentage 1.1 4.2 11.4 2.4 -0.6 -1.2 2.4 3.4 2.2 2.3 0.3 2.4 0.8
Leg fat percentage (right) 0.6 2.2 5.4 1.8 -0.2 -0.9 1.6 2.3 1.9 1.8 0.1 1.6 0.7
Arm fat-free mass (right) 0.1 0.6 1.7 -0.4 -0.9 -1.3 1.0 0.4 -0.7 0.0 -0.8 0.7 0.7
Exposure to tobacco smoke outside home 0.7 0.9 3.7 -1.2 0.3 0.1 0.0 0.0 1.1 1.0 -1.4 0.2 1.9
Comparative body size at age 10 0.4 1.1 3.3 0.4 -1.8 -1.8 1.0 0.5 0.2 0.9 0.4 0.9 1.2
Number of full brothers 0.9 1.2 4.2 0.2 1.3 1.5 -0.5 -0.2 -0.9 -0.6 -1.3 -0.8 -2.1
Worry too long after embarrassment 0.8 1.3 4.8 -1.2 0.0 0.4 0.5 2.2 2.0 1.1 0.5 0.4 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.7 -0.7 0.9 1.0 0.2 1.3 0.4 -0.1 0.1 0.0 -1.2
Wheeze or whistling in the chest in last year 0.4 0.7 2.2 1.5 -0.9 -0.6 -0.3 0.9 1.4 -0.1 0.4 -0.2 0.4
Number of children fathered 1.4 1.6 3.9 -0.8 1.2 2.0 -1.9 -1.1 -0.2 -0.9 -0.4 -1.9 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.9 1.1 -1.0 -0.7 0.8 1.4 0.2 0.4 -0.7 0.8 0.8
Age at first live birth 0.4 0.7 3.5 -0.1 0.7 0.1 0.9 -0.1 -0.8 -0.1 0.0 1.0 -1.9
Pulse wave peak to peak time 0.5 0.6 1.2 -0.5 -1.0 -1.0 0.5 0.1 0.2 1.0 -1.1 0.5 1.1
Health satisfaction 1.0 1.3 4.7 1.2 -0.9 -0.4 0.6 1.8 0.6 0.7 2.2 0.4 0.7
Shortness of breath walking on level ground 1.0 1.1 3.6 0.8 -0.4 -0.1 1.3 1.4 1.2 1.9 0.3 1.3 0.4
Qualifications: College or University degree 0.3 1.1 3.3 0.0 -0.1 -0.7 -0.1 -1.4 -1.8 -0.8 -1.7 -0.4 -1.2
Eye problems/disorders: None of the above 0.5 0.6 1.2 -0.7 1.1 1.1 0.9 0.5 -0.2 0.3 0.9 0.9 -0.5
Mouth/teeth dental problems: Loose teeth 2.2 2.6 7.2 -0.2 -2.7 -2.1 1.6 1.2 0.9 1.6 1.2 1.6 1.6
Emphysema/chronic bronchitis 0.3 0.4 1.5 -0.2 0.4 -0.2 -0.7 -0.7 0.4 -0.5 -1.2 -0.5 -0.7
Medication for pain relief, constipation, heartburn 0.7 1.1 3.6 -0.6 1.5 1.0 -0.3 -0.3 -1.9 -1.0 -0.1 -0.4 -1.7
Neck or shoulder pain in last month 0.7 1.0 3.8 1.2 -1.2 -1.9 0.5 1.4 0.7 0.3 -0.5 0.6 0.1
Medication: Blood pressure 1.9 3.3 6.1 1.5 -0.6 -0.6 2.4 2.5 2.1 2.2 0.7 2.4 1.6
Angina (self-reported) 0.6 0.7 1.5 -0.6 0.3 -0.2 -0.9 -1.1 -1.0 -1.2 -1.2 -0.8 -0.4
Migraine (self-reported) 0.6 0.7 1.8 -0.8 0.2 0.9 -0.9 -0.7 -0.5 0.0 1.3 -1.0 1.3
Medication: Ibuprofen 0.7 0.9 3.0 0.9 -0.9 -0.3 0.7 0.5 0.7 1.4 -0.3 0.9 1.7
Medication: Allopurinol 0.3 0.4 1.2 0.2 -0.3 -0.6 0.7 0.0 0.1 0.8 -0.8 0.7 1.1
Medication: Omeprazole 1.2 1.4 5.0 0.3 -0.0 0.1 1.2 2.0 2.2 1.2 0.3 1.3 0.9
Medication: Seretide 50 evohaler 0.2 0.2 1.1 0.5 -0.3 0.5 0.0 0.6 1.1 -0.2 -0.1 0.1 -0.3
Mean time to correctly identify matches 0.6 1.2 2.2 -1.4 -0.4 -0.6 -1.2 -0.4 -1.0 -1.3 -1.1 -1.2 -1.5
Heart disease (mother) 2.1 2.6 9.3 0.8 -0.7 -0.5 1.8 2.2 3.1 1.4 0.6 1.9 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.7 -0.3 -0.1 -0.0 -0.7 -1.2 0.1 -1.1 -1.3 -0.8 0.3
Whole body fat mass 1.1 4.6 10.8 2.4 -1.0 -1.8 2.8 3.3 1.9 2.4 0.3 2.6 1.2
Leg fat mass (right) 0.7 2.6 4.4 1.8 -0.7 -1.5 2.1 2.1 1.6 1.9 0.2 1.9 1.0
Arm predicted mass (right) 0.2 0.8 2.0 -0.5 -0.9 -1.4 1.3 0.6 -0.3 0.5 -0.9 1.0 1.0
Pulse rate, automated reading 0.1 0.4 0.8 0.9 -0.6 -0.8 0.2 -0.9 0.3 -0.3 -0.9 0.5 0.5
Alcohol intake frequency. 0.6 1.3 3.4 -0.2 0.8 1.4 -1.0 -0.8 -0.0 -1.2 1.7 -1.0 -1.9
Comparative height size at age 10 1.1 6.3 20.6 -0.1 -0.5 -0.7 3.6 4.5 1.9 2.5 -1.9 3.7 0.6
Number of full sisters 0.5 0.6 1.8 -1.4 -0.1 0.9 -0.6 -1.3 -0.6 -0.3 -0.2 -0.5 0.3
Suffer from ‘nerves’ 0.3 0.4 2.1 -0.7 0.2 0.6 0.3 1.4 0.6 0.2 0.6 0.3 0.2
Overall health rating 0.2 0.5 1.9 1.4 -0.4 0.1 -0.8 0.4 0.4 -0.8 1.1 -0.7 -0.1
Chest pain or discomfort 0.6 0.8 4.6 2.1 -1.3 -0.7 -0.0 -0.2 0.4 -0.3 1.1 0.0 -0.1
Had major operations 0.3 0.4 1.9 -0.2 0.3 0.2 -0.3 0.2 0.1 -0.2 1.4 -0.3 -1.1
Age at last live birth 0.4 0.6 1.6 0.5 -0.6 -1.1 1.3 -0.2 0.3 0.2 -0.5 1.2 -0.5
Family relationship satisfaction 0.3 0.4 1.2 1.0 -0.5 -0.9 -0.4 0.2 -0.4 -0.6 1.1 -0.4 0.2
Leg pain on walking 1.0 1.3 5.0 0.5 -0.2 0.2 0.5 1.5 1.9 1.1 2.2 0.5 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.0 1.7 -1.3 -1.1 0.8 0.4 -0.4 0.9 -1.1 0.7 0.5
Commuting to job workplace: Car/motor vehicle 1.1 1.3 2.3 -1.5 -1.0 -1.4 1.0 0.7 0.4 1.5 -1.5 0.9 0.6
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.5 0.2 0.5 0.8 -0.9 -0.2 -0.2 -1.1 -1.6 -0.9 -0.8
Medication: Aspirin 2.1 2.7 6.1 1.0 -1.1 -1.0 1.8 2.5 2.1 2.1 0.1 1.9 1.5
Supplements: Vitamin C 1.2 1.5 3.4 -0.5 -1.4 -1.0 1.5 1.8 1.5 0.8 0.9 1.4 0.1
Knee pain experienced in last month 1.6 2.5 6.7 1.6 -1.0 -1.4 1.5 2.6 0.7 2.0 1.0 1.7 1.4
Hypertension (Self-reported) 1.7 4.7 7.4 2.5 -0.8 -0.9 2.6 2.6 2.7 2.5 1.3 2.6 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.6 -0.7 -0.8 -0.8 -0.1 1.2 1.0 0.3 0.7 0.0 0.8
Illnesses of father: Heart disease 1.3 1.7 3.4 1.2 -1.8 -1.5 1.4 0.4 -0.7 1.6 0.9 1.4 1.5
Illnesses of siblings: Diabetes 0.8 1.0 3.1 0.7 -1.2 -1.0 1.2 1.8 0.8 1.1 0.3 0.8 0.5
Smoking status: Previous 0.4 0.5 1.7 -0.8 -0.2 -0.7 0.3 0.7 1.3 0.9 -0.6 0.3 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.7 0.0 -0.3 -0.9 1.6 1.4 0.1 1.3 -0.9 1.5 -0.6
Whole body fat-free mass 0.2 1.1 2.7 0.3 -0.9 -1.6 1.6 1.1 0.1 0.7 -0.1 1.3 1.0
Leg fat-free mass (right) 0.3 1.7 4.6 1.3 -1.4 -2.1 1.7 1.3 0.3 1.0 0.6 1.4 1.1
Arm fat percentage (left) 0.7 2.8 6.0 2.3 -0.4 -1.2 1.8 2.5 1.8 2.0 0.2 1.7 1.3
Average weekly red wine intake 0.2 0.3 0.7 0.2 0.8 0.3 0.7 0.8 0.1 0.6 -0.1 0.7 0.7
Handedness (chirality/laterality): Left-handed 0.8 1.0 3.0 -1.1 1.2 1.1 -0.4 1.7 -0.1 0.2 1.7 -0.3 0.2
Mood swings 0.4 0.8 3.1 -0.2 -1.1 -0.7 -0.3 1.8 1.3 0.3 0.8 -0.1 0.3
Loneliness, isolation 0.3 0.4 1.9 0.8 0.3 0.7 -0.1 0.5 0.8 0.2 1.4 -0.1 0.1
Long-standing illness, disability or infirmity 1.0 1.5 5.1 2.3 -1.4 -0.9 -0.4 0.9 1.1 -0.6 1.9 -0.3 0.6
Ever had bowel cancer screening 0.7 0.8 2.1 -0.0 0.7 1.4 -0.5 1.4 1.1 0.1 1.4 -0.2 -0.5
Diabetes diagnosed by doctor 0.4 0.7 3.4 0.5 -0.8 -1.4 -0.2 -0.3 -0.0 0.1 -1.8 -0.2 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 4.6 0.4 -1.3 -1.6 1.2 1.6 1.3 2.1 -0.5 1.3 1.2
Friendships satisfaction 0.4 0.5 1.3 -0.7 0.5 0.9 -1.1 0.5 -0.5 -0.1 0.6 -1.1 0.3
Qualifications: nursing, teaching 0.7 1.1 2.6 0.3 -0.7 -1.1 1.1 1.1 -0.2 1.2 -0.8 1.4 1.6
Commuting to job workplace: Walk 2.2 2.3 5.1 0.6 1.9 2.2 -1.9 -1.0 0.1 -2.3 0.3 -1.9 -1.2
Eye problems/disorders: Cataract 0.8 0.9 3.2 1.5 -1.8 -1.2 0.3 0.8 1.0 0.2 0.1 0.3 0.7
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 5.0 0.9 -2.2 -1.9 0.2 0.6 0.5 0.5 -0.6 0.2 1.4
Medication for cholesterol 0.6 1.0 3.3 0.0 -0.6 -1.1 0.8 0.2 -0.5 0.8 -1.5 0.9 1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 4.5 -0.3 -1.0 -1.5 1.4 1.1 2.1 1.1 -0.3 1.6 1.3
Back pain experienced in last month 0.9 1.4 5.3 0.3 -2.3 -2.2 -0.2 -1.3 -0.1 -1.0 -0.2 -0.1 -0.7
Mineral and other dietary supplements 0.6 0.8 4.0 0.8 0.9 0.5 -0.4 -2.0 0.1 0.2 0.7 -0.4 -1.1
Breast cancer (self-reported) 0.8 1.0 3.3 -0.4 -1.8 -1.7 0.6 -0.5 -0.9 0.6 -0.8 0.4 1.0
Asthma (self-reported) 0.3 0.6 1.6 0.3 -0.1 0.2 -1.1 -0.9 -0.2 -1.2 0.3 -1.3 -0.7
Osteoporosis (self-reported) 0.5 0.6 1.7 -0.3 0.3 0.3 -0.8 -1.0 -0.5 -1.3 -0.6 -0.9 -1.1
Osteoarthritis (self-reported) 0.6 0.8 2.3 0.3 0.9 0.5 -0.3 1.3 0.7 -0.9 -1.1 0.0 -1.5
Medication: Aspirin 2.4 3.2 6.5 1.2 -1.5 -1.4 2.0 2.5 1.9 2.3 -0.2 2.0 1.7
Medication: Gliclazide 1.0 1.1 4.0 -0.7 0.3 -0.2 -0.4 -1.6 -1.9 -0.1 -2.0 -0.4 -0.4
Illnesses of father: None of the above (group 1) 1.9 2.4 4.6 -1.2 1.9 1.6 -1.9 -1.3 -0.4 -2.1 -1.4 -2.0 0.0
Smoking status: Current 1.5 2.4 9.5 0.8 -2.4 -3.1 1.1 0.4 1.1 0.9 0.1 1.1 1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 3.2 -1.8 -0.7 -0.7 -0.8 0.3 -0.7 -1.0 0.8 -0.9 -1.5
Whole body water mass 0.2 1.1 2.9 0.3 -1.0 -1.7 1.7 1.1 0.1 0.7 -0.1 1.4 0.9
Leg predicted mass (right) 0.3 1.6 4.4 1.2 -1.4 -2.1 1.6 1.1 0.2 0.9 0.6 1.4 1.1
Arm fat mass (left) 0.8 3.2 6.5 2.1 -0.8 -1.6 2.2 2.5 1.7 2.0 0.3 2.0 1.4
Number of self-reported non-cancer illnesses 0.2 0.3 2.0 0.1 -0.6 -0.2 -0.1 -0.0 0.1 -0.5 -0.4 0.1 -1.4
Average weekly champagne plus white wine intake 0.4 0.5 1.3 0.9 -0.6 -0.2 1.1 0.4 0.1 0.2 -1.0 1.1 0.6
Miserableness 0.1 0.2 1.2 -0.5 -0.0 0.5 -0.3 1.1 -0.4 -0.0 -0.4 -0.2 0.1
Guilty feelings 0.5 0.8 2.3 0.4 1.3 1.4 -0.4 0.8 0.0 -0.8 0.8 -0.2 -1.5
Wears glasses or contact lenses 1.6 1.8 3.8 -1.1 0.7 0.9 -1.9 -1.7 -1.0 -1.9 -0.8 -1.7 -0.9
Ever taken oral contraceptive pill 1.5 1.7 4.2 1.9 0.7 0.9 1.2 -0.1 1.0 1.9 0.3 1.2 2.0
Hearing aid user 0.2 0.2 0.8 0.5 -0.3 0.3 0.4 0.3 -0.8 -0.0 0.4 0.2 -0.9
Mother’s age at death 0.3 0.3 1.0 -0.1 -1.0 -0.8 0.6 0.1 -0.0 -0.0 0.9 0.7 -0.0
Financial situation satisfaction 0.7 0.9 5.8 0.1 0.5 1.2 -0.5 0.3 0.2 0.5 2.4 -0.6 0.5
Tinnitus: Yes, now most or all of the time 1.1 1.2 4.5 1.1 -2.1 -2.0 0.6 0.1 0.1 1.3 -0.6 0.5 0.1
Commuting to job workplace: Public transport 0.9 1.1 3.5 0.4 -1.0 -1.1 1.8 -0.3 0.9 0.5 -0.3 1.9 0.2
Eye problems/disorders: Glaucoma 2.2 2.6 6.4 -0.2 0.1 0.0 -1.4 -2.2 -2.0 -1.9 -2.5 -1.3 -1.7
Medication: Blood pressure 0.4 0.8 4.5 0.4 0.2 0.2 0.5 0.7 1.4 0.5 2.1 0.5 -0.5
Pain type(s) experienced in last month: Hip pain 1.2 1.6 5.2 -1.0 0.0 0.5 -2.3 -0.5 -0.2 -1.9 0.5 -2.2 -0.6
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.8 -1.3 -1.1 -0.9 0.1 1.2 -0.0 -0.1 -0.8 -0.0 0.9
High cholesterol (Self-reported) 0.4 0.7 2.5 0.4 0.3 0.7 0.5 1.4 1.6 0.8 -1.0 0.3 0.1
Medication: Bendroflumethiazide 0.7 1.0 2.3 0.4 1.2 1.4 -0.9 -0.8 -0.1 -1.2 1.5 -0.7 -1.2
Medication: Paracetamol 0.2 0.3 1.0 0.2 0.3 1.0 -0.4 -0.8 0.5 0.1 0.6 -0.5 -0.0
Medication: Lisinopril 1.8 2.4 7.7 1.5 -0.0 0.1 1.4 1.4 2.8 1.6 0.8 1.4 2.2
Medication: Atorvastatin 0.1 0.2 0.7 -0.3 0.5 0.9 -0.2 -0.2 0.5 0.3 0.4 -0.3 0.1
Illnesses of father: High blood pressure 3.0 3.7 7.7 1.8 -1.9 -1.3 2.4 1.4 1.3 2.8 0.2 2.6 2.2
Alcohol drinker status: Never 1.1 1.3 5.4 -0.7 1.0 1.3 -1.0 0.5 1.1 -0.6 2.3 -1.0 -0.6
Ever smoked 1.0 1.7 5.5 1.2 -1.5 -2.3 1.0 0.8 1.3 0.9 -0.9 0.9 1.5
Basal metabolic rate 0.3 1.6 3.6 0.9 -1.1 -1.9 1.9 1.4 0.3 1.0 -0.1 1.6 1.1
Leg fat percentage (left) 0.5 1.7 4.6 2.1 0.1 -0.5 1.2 2.1 1.5 1.5 0.3 1.2 0.3
Arm fat-free mass (left) 0.3 1.4 3.3 0.6 -1.4 -1.7 1.8 1.3 0.3 0.9 0.1 1.5 0.8
Number of operations (self-reported) 3.2 4.7 9.4 2.9 -2.2 -1.6 1.7 2.4 3.1 1.9 2.0 1.7 1.7
Average weekly beer plus cider intake 0.7 1.1 2.8 1.1 -0.8 -1.2 0.1 0.9 1.1 1.6 0.0 -0.1 1.7
Irritability 0.4 0.8 3.9 -2.0 0.0 -0.2 0.2 1.6 0.4 0.8 0.1 0.2 -0.3
Risk taking 1.5 2.2 12.1 1.4 -0.4 0.4 1.4 1.3 1.4 1.0 3.5 1.1 -0.2
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.8 0.0 -0.7 -0.9 -0.2 -0.9 -0.8 -0.4 -0.5 -0.2 0.6
Fractured/broken bones in last 5 years 1.0 1.2 4.3 1.4 -0.4 -0.5 -0.0 0.9 1.8 0.7 2.1 0.1 1.1
Age started oral contraceptive pill 0.9 1.1 2.2 -1.5 0.7 0.8 -1.2 -0.9 -0.2 -1.4 0.8 -1.0 -1.4
Diastolic blood pressure, automated reading 3.0 9.2 16.9 4.1 -1.8 -1.9 3.4 3.5 4.1 3.3 2.2 3.4 1.1
Ever depressed for a whole week 0.9 1.1 3.1 -1.1 0.3 0.4 -1.7 -0.8 -0.6 -1.2 -0.8 -1.8 0.4
Unable to work because of sickness or disability 1.4 1.8 4.1 1.0 0.9 0.9 -2.0 -0.2 1.4 -1.3 1.8 -2.0 0.8
Commuting to job workplace: Cycle 1.9 2.3 6.7 -0.2 1.0 0.4 -1.3 -1.8 -2.1 -1.6 -1.3 -1.1 -2.6
Myopia 1.2 1.7 4.8 -1.2 0.5 0.7 -1.7 -0.8 -0.5 -2.2 1.3 -1.6 -1.3
Vascular/heart problems diagnosed by doctor 1.7 4.7 7.3 -2.6 0.9 1.2 -2.7 -2.5 -2.6 -2.4 -1.0 -2.7 -1.8
Cholesterol lowering medication 0.6 0.9 1.9 -0.4 0.3 0.9 -1.1 -1.1 -0.2 -1.3 -0.5 -1.2 -1.4
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 5.6 -0.2 -0.8 -0.5 1.6 2.2 2.4 1.8 0.9 1.7 0.9
Pain experienced in last month 3.2 5.3 8.9 -2.2 3.0 2.9 -1.9 -2.6 -2.1 -2.3 -1.5 -2.0 -2.0
Supplements: Calcium 0.3 0.3 1.5 -0.3 -0.6 0.3 0.3 0.0 -0.3 -0.2 1.2 0.4 0.6
Basal cell carcinoma (self-reported) 0.5 0.5 1.7 0.1 -0.1 -0.2 -1.1 -0.8 -0.6 -1.0 -0.8 -1.3 -0.1
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.7 0.2 0.3 -0.1 -0.3 0.8 1.3 -0.0 -0.4 -0.3 0.0
Deep venous thrombosis (DVT) (self-reported) 1.8 2.4 6.1 2.4 -0.7 -0.7 1.6 1.5 1.3 1.1 2.5 1.8 -0.1
Heart disease (siblings) 0.6 0.7 1.9 -0.3 0.9 1.2 -0.3 0.2 -1.3 -0.3 -1.2 -0.5 -1.4
Alcohol drinker status: Previous 0.9 1.1 2.2 1.3 0.1 0.7 -1.5 -1.4 -0.2 -1.0 1.2 -1.3 -0.4
Pack years of smoking 0.5 0.7 2.3 0.5 -0.3 0.1 -1.0 -0.6 -1.1 -0.6 0.6 -1.0 -1.5
Impedance of whole body 0.4 2.3 7.8 0.9 1.0 1.3 1.6 2.8 1.6 1.2 -0.8 1.7 -1.3
Leg fat mass (left) 0.6 2.3 4.5 1.9 -0.4 -1.3 1.9 2.1 1.4 1.8 0.4 1.8 0.7
Arm predicted mass (left) 0.3 1.3 3.6 0.4 -1.4 -1.9 1.6 1.1 0.2 0.8 -0.1 1.4 1.0