Hub : Genes

CRISPLD2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.2500	0.0880	7.9e-03	-0.006	NA	0.063	NA	0.006	7.1e-01	NA	8.2e-04	NA	1.7e-01
2	NTR	Blood	0.1042	0.0211	2.3e-08	0.051	0.034	0.069	0.075	0.072	4.8e-16	4.5e-11	3.1e-21	3.5e-23	4.6e-22
3	YFS	Blood	0.3925	0.0311	0.0e+00	0.186	0.226	0.307	0.315	0.305	1.8e-58	2.3e-72	1.0e-102	6.9e-106	4.7e-102
4	TCGA	Colon Adenocarcinoma	0.2380	0.0570	2.8e-06	0.230	0.132	0.200	NA	0.219	1.7e-13	4.9e-08	9.4e-12	NA	7.6e-13
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.1315	0.0365	1.3e-06	0.090	0.069	0.083	NA	0.082	2.6e-10	3.0e-08	1.2e-09	NA	1.5e-09
6	TCGA	Lung Adenocarcinoma	0.0835	0.0312	1.3e-03	0.023	0.021	0.012	NA	0.020	8.2e-04	1.5e-03	1.2e-02	NA	2.0e-03
7	TCGA	Lung Squamous Cell Carcinoma	0.1104	0.0353	1.0e-04	0.056	0.037	0.057	NA	0.048	6.2e-07	4.5e-05	4.4e-07	NA	3.6e-06
8	TCGA	Prostate Adenocarcinoma	0.0831	0.0327	3.1e-03	-0.002	0.011	-0.002	NA	-0.001	5.4e-01	2.2e-02	7.4e-01	NA	4.1e-01
9	TCGA	Stomach Adenocarcinoma	0.1230	0.0490	4.1e-03	0.075	0.028	0.029	NA	0.053	4.0e-06	3.7e-03	3.3e-03	NA	1.0e-04
10	TCGA	Thyroid Carcinoma	0.0760	0.0290	1.0e-03	-0.003	0.004	0.001	NA	0.004	9.7e-01	1.3e-01	2.4e-01	NA	1.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.6	1.5	-1.2	-0.1	-0.3	0.4	1.2	1.1	0.7	0.2	0.3	0.9
Bipolar Disorder or Schizophrenia	0.4	0.9	4.3	-2.1	-0.7	-1.1	0.8	1.0	0.2	0.6	-0.3	0.7	0.6
Depressed Affect (Nagel 2018)	0.2	0.5	1.4	-0.5	0.3	1.2	-0.4	1.1	0.9	0.0	0.8	0.1	-0.1
Depression (Nagel 2018)	0.3	0.5	2.6	-0.1	1.1	1.6	-0.8	-0.1	-0.2	-0.4	0.1	-0.6	-0.0
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.6	0.4	-0.9	-1.9	0.1	1.6	-0.1	-0.1	-0.1	0.0	0.9
Neuroticism (Nagel 2018)	0.5	1.1	2.7	-0.6	0.4	1.4	0.5	1.6	1.6	0.6	1.5	0.9	-0.6
Schizophrenia (2018)	0.3	0.7	3.6	-1.9	-0.8	-1.2	0.6	0.3	-0.4	0.4	-0.6	0.7	-0.0
Schizophrenia vs Biploar Disorder	0.7	1.0	1.7	0.5	0.6	1.1	-1.2	-1.1	-0.8	-1.3	0.3	-1.1	-1.2
Worry (Nagel 2018)	0.7	1.5	3.4	-0.3	0.7	1.7	0.9	1.6	1.6	0.8	1.8	1.0	-1.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	-0.4	-0.8	-1.3	-0.1	-0.3	-1.3	-0.7	0.1	-0.3	-0.8
Alzheimer’s Disease (in father)	0.9	1.0	2.8	0.5	1.2	1.6	-0.6	-0.2	-1.0	-0.8	-0.8	-0.7	-1.7
Alzheimer’s Disease (including proxy)	0.5	0.7	2.2	-0.4	0.1	0.4	-0.6	-0.6	-1.3	-1.1	-0.3	-0.9	-1.5
Crohns Disease (2017)	0.6	1.4	4.1	-1.5	2.0	2.0	-0.9	-0.4	-0.5	-1.1	0.6	-0.7	-0.7
Irritable Bowel Disease (IBD)	0.4	0.9	2.6	0.2	0.1	0.0	1.2	0.8	1.6	1.0	1.3	1.3	0.4
Ulcerative Colitis (UC)	2.5	4.6	8.2	1.8	-1.9	-1.9	2.6	2.1	2.9	2.2	1.9	2.6	0.8
Major Depression (MDD)	0.1	0.2	0.5	-0.7	0.4	0.7	0.0	0.0	0.5	0.0	0.3	0.0	0.6
Reaction Time	0.8	1.5	4.3	-0.5	-0.3	-0.6	-1.0	-1.2	-1.6	-1.6	-1.0	-1.1	-2.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.8	0.6	-0.5	-1.2	0.1	0.7	0.3	0.4	0.9	0.2	1.3
Breast Cancer	0.1	0.2	0.8	-0.9	-0.1	-0.8	-0.3	-0.4	-0.1	-0.5	-0.4	-0.2	0.3
Ovarian Cancer	0.4	0.5	3.4	-0.2	0.1	0.3	0.6	0.2	0.5	1.0	-1.8	0.4	0.1
Prostate Cancer	0.2	0.3	1.4	0.3	-0.9	-1.2	-0.0	-0.1	-0.2	0.1	-1.0	0.0	-0.4
Age at First Birth	0.7	1.0	4.9	-0.6	0.0	0.3	1.2	2.2	0.9	0.8	0.6	1.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	-0.1	-0.1	-0.2	-0.3	-1.2	-1.0	-0.3	-0.7	-0.3	0.8
Coronary Artery Disease (CAD)	3.8	4.5	8.6	-1.1	0.5	1.0	-2.9	-2.5	-2.8	-2.5	0.0	-2.8	-2.4
Crohns Disease (2012)	1.0	1.6	3.3	-1.4	1.8	1.6	-1.4	-1.3	-0.7	-1.2	-0.6	-1.3	-0.4
Mean Putamen Volume	0.3	0.3	1.3	-0.1	0.6	1.1	0.6	0.1	-0.1	0.3	0.3	0.7	-0.3
Fasting Glucose	0.4	0.5	1.4	0.4	0.0	-0.0	0.8	1.2	1.1	0.9	0.4	0.6	0.7
HbA1C	0.4	0.5	1.4	0.5	0.6	0.4	-0.7	-0.4	-0.5	-0.8	-1.2	-1.0	0.3
HDL Cholesterol	0.3	0.5	1.8	0.2	-0.1	-0.6	1.1	1.3	0.1	0.2	0.2	1.2	-0.3
LDL Cholesterol	0.5	0.8	3.5	0.9	-0.7	-1.0	-0.6	-1.1	0.0	-0.0	-0.6	-0.6	1.9
Lupus	1.1	1.7	4.2	1.8	-1.1	-1.5	1.1	2.0	0.9	0.8	1.4	1.0	0.8
Neuroticism (2016)	0.4	0.5	4.0	0.3	-0.1	-0.3	-0.4	0.6	0.2	0.4	2.0	-0.3	-0.2
Primary Biliary Cirrhosis	2.0	2.8	11.0	-1.3	1.2	1.0	-0.7	-0.5	-1.8	-2.3	-1.7	-0.7	-3.3
Rheumatoid Arthritis	0.2	0.3	1.2	1.1	-0.5	-0.9	-0.3	0.1	0.4	-0.1	0.3	-0.3	0.6
Schizophrenia (2014)	0.1	0.2	0.6	-0.8	0.4	0.0	0.2	0.5	0.3	-0.2	-0.5	0.1	-0.1
Triglycerides	0.4	0.6	2.5	0.3	-0.8	-1.1	-0.3	-0.2	0.6	0.4	-1.0	-0.4	1.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.9	-0.2	1.4	1.2	-0.1	0.5	-1.0	-0.1	-0.4	0.1	-0.4
Ulcerative Colitis	0.5	0.8	1.6	0.6	-0.7	-1.1	1.2	0.5	1.3	0.8	-0.2	1.3	0.5
Blood Eosinophil Count	0.2	1.7	4.6	0.3	-0.5	-0.8	1.0	1.3	2.1	1.1	2.1	1.0	1.6
Blood Platelet Count	0.1	1.1	2.8	0.9	1.0	0.7	-1.6	-1.3	0.5	-0.9	-0.7	-1.7	-0.3
Blood Red Count	0.2	1.7	7.3	1.4	-0.8	-0.8	-1.2	-2.7	-1.2	-1.2	0.4	-1.2	-0.8
Blood White Count	0.2	1.5	4.7	0.1	0.0	-0.8	-2.2	-1.6	0.3	-1.5	0.7	-1.9	0.1
Heel T-Score	0.2	1.3	3.9	1.0	-0.1	-0.0	-0.6	-1.9	-1.6	0.1	-2.0	-0.7	0.7
BMI	0.4	2.4	5.2	2.3	-1.5	-1.4	1.7	1.1	1.2	2.0	0.4	1.7	1.5
Height	0.7	13.2	36.1	-0.5	-0.3	-2.0	5.8	6.0	1.9	2.8	-3.7	5.7	-0.4
Waist Hip Ratio (WHR)	0.8	3.5	17.6	0.9	0.3	-0.1	-0.2	-2.0	-2.1	-1.5	-4.2	-0.2	-2.5
Systolic Blood Pressure	0.7	3.3	9.2	3.0	-1.9	-2.1	1.9	1.5	2.1	1.5	0.3	1.8	0.1
Smoking Status	0.6	1.4	6.9	-0.4	-1.4	-2.6	0.8	0.6	1.4	0.8	0.3	0.8	0.7
Allergy or Eczema	0.8	2.2	5.8	1.4	-1.8	-1.5	2.4	0.4	0.6	1.4	0.6	2.4	0.3
Cardiovascular Disease	0.6	1.8	5.4	2.3	-0.8	-0.3	1.7	1.9	1.3	1.0	0.1	1.7	0.8
Hypothyroidism (self reported)	0.2	0.6	2.8	0.3	0.6	0.2	0.5	1.7	-0.1	0.9	-0.4	0.5	0.8
Respiratory disease	0.9	1.9	6.0	-0.3	1.2	0.9	-1.7	-0.7	-1.2	-2.0	0.3	-1.5	-2.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.7	-0.4	0.1	-0.9	-0.5	-1.3	-0.9	-0.2	-1.9	-0.4	-1.0
Lung FEV1/FVC ratio	0.1	0.7	1.8	0.2	-1.3	-0.9	-0.5	-1.1	-0.6	-1.0	-0.2	-0.7	0.9
Lung FVC	0.9	4.8	15.4	0.6	-1.7	-1.4	1.8	3.9	2.8	1.9	3.0	1.8	1.1
Neuroticism	0.8	1.9	6.0	-1.1	-0.4	0.1	0.6	2.4	2.1	0.6	2.4	0.8	-0.3
Chronotype (morning person)	1.3	3.0	5.4	-0.5	1.8	2.3	-1.6	-2.2	-1.9	-1.6	-0.8	-1.6	-2.0
Hair Pigment	0.1	1.5	6.7	2.6	-0.8	-0.5	-0.2	-0.6	-1.9	-0.5	0.5	-0.3	-1.6
Tanning	0.1	1.1	3.0	-1.7	0.7	0.8	-1.3	-0.0	1.5	-1.2	-0.6	-1.2	0.2
Hand grip strength (left)	0.7	1.9	5.0	-0.7	2.1	1.8	0.0	-0.8	-2.1	-0.4	-2.2	-0.3	-1.0
Number of treatments/medications taken	0.4	0.6	2.7	0.5	-1.1	-0.0	0.5	0.6	0.9	0.6	1.6	0.5	0.4
Average weekly spirits intake	1.2	1.5	4.1	-1.1	-0.0	-0.1	0.9	2.0	1.8	1.4	0.7	1.1	1.5
Sensitivity / hurt feelings	0.8	1.3	4.7	0.6	0.7	1.4	0.8	2.2	1.5	0.4	1.2	0.8	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.2	1.0	0.6	1.1	-0.9	0.2	-0.5	-0.4	0.6	-0.7	-0.2
Hearing difficulty/problems: Yes	0.7	1.0	2.3	0.1	-1.1	-1.5	1.1	0.9	-0.2	0.2	-0.9	1.2	1.5
Relative age of first facial hair	0.5	1.0	2.3	-0.2	0.7	0.2	-1.3	-1.5	-1.1	-1.2	-1.0	-1.2	-0.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	5.0	0.1	2.1	2.2	-0.8	0.6	-0.2	-1.4	0.8	-0.5	-1.3
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.0	0.2	-1.4	-1.0	0.8	-1.0	-0.2	0.7	-1.1	0.8	0.7
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	0.1	-0.9	-0.4	-0.2	-0.5	0.6	-0.6	0.9	-0.2	0.0
Systolic blood pressure, automated reading	0.7	1.9	5.0	2.2	-1.0	-1.5	0.8	1.5	2.2	1.3	0.6	0.8	0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.8	0.8	0.5	-0.6	-0.5	-0.7	-0.1	-1.0	-0.6	0.2
Angina	0.8	1.1	2.0	-0.8	0.5	-0.1	-1.2	-1.2	-1.2	-1.4	-1.4	-1.2	-0.5
Medication for hormone replacement therapy	2.7	3.0	6.4	-0.5	1.9	2.5	-1.8	-1.7	-1.8	-1.5	-0.3	-1.8	-2.1
Vitamin and mineral supplements	0.2	0.2	0.7	0.9	0.5	0.3	-0.0	-0.3	0.8	0.3	0.5	-0.0	0.5
Supplements: Zinc	0.6	0.6	3.9	0.3	-0.6	-0.4	0.6	1.0	0.4	-0.0	0.5	0.5	-2.0
Medication: Co-codamol	0.2	0.3	0.9	0.6	-0.3	-0.4	-0.1	-0.9	0.5	-0.3	0.1	-0.1	-0.9
Medication: Metformin	0.4	0.6	2.4	-0.4	0.5	0.3	-0.8	-0.8	-0.4	-0.7	-1.5	-0.8	-0.6
Diabetes (father)	0.3	0.3	1.5	0.2	-0.1	-0.4	-0.4	0.3	-0.4	-0.3	1.2	-0.5	-0.9
Diabetes (mother)	0.9	1.2	4.3	-0.7	0.9	0.6	-0.4	-0.3	-2.1	-1.6	-0.6	-0.2	-1.7
Severe depression (siblings)	0.6	0.7	1.6	-0.0	-0.9	-1.3	0.9	0.7	-0.7	0.9	-0.4	0.7	1.0
Pack years adult smoking proportion	0.3	0.4	1.2	1.0	-0.8	-0.4	-0.6	-0.5	-0.4	-0.2	0.6	-0.6	-1.1
Impedance of leg (right)	0.3	1.5	3.1	-0.2	1.1	1.4	1.1	1.8	1.3	0.7	-1.4	1.2	-1.4
Leg fat-free mass (left)	0.5	2.5	5.3	1.2	-1.5	-2.3	2.1	1.6	0.8	1.4	0.5	1.9	1.6
Trunk fat percentage	1.2	4.9	14.3	2.6	-0.6	-1.2	2.8	3.8	2.2	2.4	0.3	2.8	0.6
Hand grip strength (right)	0.5	1.5	6.9	-0.8	1.5	1.5	0.4	0.3	-1.3	-0.4	-2.6	-0.0	-0.7
Townsend deprivation index at recruitment	0.5	0.6	1.9	-0.5	0.3	-0.4	-1.4	0.3	0.8	-0.4	1.2	-1.2	0.3
Current tobacco smoking	1.4	2.4	8.5	0.6	-2.6	-2.9	1.1	0.5	1.2	1.0	0.3	1.1	1.7
Average weekly fortified wine intake	1.6	1.9	10.2	-1.1	0.7	-0.0	-1.2	-1.6	-1.1	-0.7	-3.2	-1.3	0.3
Maternal smoking around birth	0.3	0.5	1.8	-1.0	0.7	1.4	0.0	0.7	0.1	-0.2	-0.8	-0.1	-0.4
Fed-up feelings	0.2	0.4	1.7	-0.3	-0.2	0.5	-0.5	1.0	1.3	0.3	0.9	-0.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.8	-0.0	-0.0	0.3	-1.6	-0.9	-0.4	-1.2	0.0	-1.7	-0.3
Relative age voice broke	1.2	1.8	3.4	1.0	1.4	1.0	-1.7	-1.6	-1.3	-1.7	-0.6	-1.8	-0.7
Taking other prescription medications	0.3	0.4	1.7	0.1	0.1	0.8	-0.4	0.1	-0.7	-0.8	0.7	-0.3	-1.3
Age when periods started (menarche)	1.0	2.4	5.3	-1.9	1.0	1.2	-1.7	-2.3	-0.9	-1.0	1.8	-1.9	-0.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	4.0	1.0	-1.6	-0.7	0.1	-0.1	2.0	0.3	-0.7	0.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	3.0	0.0	-0.8	-0.8	0.1	-0.5	-0.6	0.5	-1.7	-0.1	0.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	5.2	2.3	-1.3	-1.0	0.6	1.1	1.2	0.7	1.3	0.6	0.9
Qualifications: CSEs or equivalent	0.4	0.6	1.2	-1.1	0.8	0.4	0.5	0.7	0.5	1.1	-0.9	0.5	0.5
Serious illness, injury or assault to yourself	1.2	1.4	2.6	1.4	-1.0	-0.8	1.6	0.6	1.4	1.0	1.4	1.6	0.4
High blood pressure	1.8	4.9	7.7	2.6	-0.9	-1.1	2.8	2.7	2.6	2.6	0.9	2.8	1.8
Hayfever, allergic rhinitis or eczema	0.3	0.8	2.1	0.7	-1.1	-0.8	1.5	-0.2	-0.4	0.9	0.6	1.4	0.1
Multivitamins +/- minerals	0.3	0.4	1.7	0.3	-1.3	-1.0	0.3	0.2	-0.7	0.1	-0.6	0.3	-0.5
Stomach or abdominal pain in last month	0.9	1.1	2.3	0.5	-0.5	-0.0	1.4	1.5	1.5	1.2	0.9	1.4	0.3
Supplements: Glucosamine	0.5	0.6	3.6	0.0	-0.4	-0.5	0.7	1.9	-0.5	0.5	-0.6	0.8	0.6
Diverticular disease/diverticulitis (self-reported)	7.0	8.4	18.0	2.2	-3.1	-2.3	3.2	3.1	4.2	2.8	2.1	3.2	1.6
Medication: Atenolol	0.2	0.3	1.1	0.3	-0.0	0.8	0.7	-0.3	-1.0	-0.4	0.3	0.6	-0.2
Medication: Levothyroxine sodium	0.9	1.6	5.5	-0.4	-0.5	-0.1	1.1	2.3	1.7	1.4	-0.8	1.1	1.5
Sitting height	0.3	2.2	4.5	1.7	-2.1	-1.8	1.4	0.7	1.7	1.5	1.1	1.2	1.4
Chronic bronchitis/emphysema (father)	2.6	3.0	6.2	-0.5	-1.4	-1.9	1.8	2.2	1.9	2.5	-0.2	2.0	1.5
High blood pressure (mother)	2.0	2.8	6.3	2.5	-0.7	-0.1	2.1	2.3	0.8	1.3	2.0	2.2	0.4
Body mass index (BMI)	0.4	1.7	3.4	1.9	-1.2	-1.7	1.2	0.9	1.1	1.4	0.7	1.1	1.5
Impedance of leg (left)	0.3	1.6	4.8	0.2	1.4	1.9	0.6	1.5	0.7	0.2	-1.2	0.7	-2.2
Leg predicted mass (left)	0.4	2.3	5.1	1.1	-1.4	-2.3	2.0	1.5	0.7	1.4	0.5	1.8	1.5
Trunk fat mass	1.1	4.7	13.0	2.4	-0.7	-1.5	2.8	3.6	1.9	2.4	0.1	2.7	0.8
Waist circumference	0.4	1.6	3.6	1.4	-0.7	-1.3	1.9	1.3	0.8	1.3	-0.8	1.8	0.5
Number of incorrect matches in round	0.8	1.3	3.8	-1.9	-0.3	-0.7	0.2	-0.8	-1.0	0.1	-1.8	0.2	-1.9
Past tobacco smoking	0.6	1.1	3.1	0.0	0.9	1.8	-0.8	-1.0	-1.4	-1.1	0.6	-0.7	-1.4
Alcohol usually taken with meals	0.3	0.5	3.5	1.0	0.0	0.0	-0.1	-0.4	0.2	-0.6	-1.9	-0.3	0.4
Nervous feelings	0.7	1.3	2.8	0.5	-0.4	0.1	1.3	1.7	1.3	1.3	1.6	1.4	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.0	-0.6	-0.6	-0.2	-0.6	1.4	-0.3	-0.6	0.9	-0.3	-0.8
Hearing difficulty/problems with background noise	1.0	1.6	4.2	1.0	-0.8	-1.0	1.2	2.0	0.6	1.5	-0.2	1.2	1.8
Hair/balding pattern: Pattern 2	0.4	0.5	1.7	1.3	0.6	1.2	0.4	-0.2	1.0	0.6	-0.4	0.4	0.1
Had menopause	0.3	0.4	1.6	-0.5	-0.9	-1.2	-0.2	-0.7	-0.3	-0.7	-0.3	-0.2	0.2
Had other major operations	1.0	1.2	3.8	1.5	-1.9	-1.6	0.8	0.6	0.7	0.4	0.1	0.8	1.0
Forced vital capacity (FVC)	1.1	4.4	9.2	1.0	-1.5	-1.6	3.0	3.0	1.8	2.4	1.1	2.8	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.7	0.2	-1.4	-2.2	1.0	0.6	1.3	1.1	-1.8	0.8	1.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	-0.3	0.5	-0.0	-0.3	0.6	-0.7	-0.4	-0.8	-0.3	-0.5
Qualifications: None of the above	0.6	1.3	6.8	-0.2	-1.2	-0.7	0.6	0.5	2.6	1.0	1.1	0.8	0.5
Financial difficulties in last 2 years	0.7	0.9	2.4	1.2	-0.7	-0.3	0.7	0.9	1.5	0.8	1.6	0.5	0.2
Mouth/teeth dental problems	1.2	1.8	5.9	-0.0	2.4	2.4	-0.7	-1.0	-1.5	-1.2	-0.2	-0.7	-0.6
Heart attack	0.2	0.2	1.3	0.1	0.3	-0.1	-0.4	0.5	1.1	-0.2	-0.5	-0.4	-0.2
Allergy	0.2	0.4	1.7	-1.3	0.5	0.3	-0.8	0.6	-0.3	-0.4	-0.7	-0.8	-0.1
Pain all over the body in last month	2.5	2.7	6.0	2.5	-1.7	-1.3	1.4	1.1	2.4	1.1	0.8	1.5	1.8
Diabetes (self-reported)	0.3	0.5	2.6	-0.1	-0.0	-0.5	-0.6	-0.8	-0.2	-0.0	-1.6	-0.7	-0.8
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.9	0.0	-1.7	-1.5	1.4	0.9	0.1	0.8	-0.8	1.5	0.2
Medication: Ramipril	0.8	1.0	3.0	0.2	0.5	0.7	1.0	1.7	1.1	1.4	-0.8	0.8	0.7
Medication: Simvastatin	0.2	0.2	0.7	0.8	-0.1	0.5	0.4	0.4	0.9	0.3	-0.5	0.4	0.1
Fluid intelligence score	0.5	1.0	3.1	0.7	-1.2	-1.5	0.5	0.6	0.6	0.2	1.3	0.5	1.8
Illnesses of siblings	1.2	1.6	3.7	-1.0	0.2	-0.2	-1.7	-1.9	-0.5	-1.6	-1.7	-1.5	0.9
Neuroticism score	0.8	1.7	8.6	-0.7	0.2	0.6	0.6	2.9	1.6	0.7	1.7	0.8	-0.3
Weight	0.8	4.0	7.5	1.9	-1.2	-2.1	2.7	2.7	1.5	2.1	-0.0	2.5	1.5
Impedance of arm (right)	0.9	4.1	14.2	1.7	0.5	0.5	2.3	3.8	2.7	2.0	0.7	2.5	-0.6
Arm fat percentage (right)	1.0	4.0	8.0	2.8	-0.7	-1.5	2.1	2.8	2.4	2.3	0.9	2.1	1.3
Trunk fat-free mass	0.1	0.6	1.8	-0.2	-0.6	-1.2	1.3	0.9	-0.2	0.4	-0.5	1.0	0.7
Hip circumference	1.4	6.0	12.4	1.2	-1.6	-2.4	3.5	3.2	1.7	3.0	0.4	3.3	2.0
Time employed in main current job	0.3	0.4	1.2	0.5	0.3	-0.0	-0.3	-0.2	0.4	-0.7	-1.1	-0.5	-1.1
Alcohol intake versus 10 years previously	0.3	0.5	0.9	-0.8	-0.9	-0.7	-0.1	-0.7	-0.7	-0.7	0.8	-0.2	-0.8
Father’s age at death	2.8	3.8	10.7	-3.3	0.4	0.1	-1.6	-2.2	-2.7	-2.1	-2.4	-1.6	0.2
Worrier / anxious feelings	0.3	0.6	2.6	-1.6	0.5	0.7	0.0	0.9	0.7	-0.1	0.4	-0.1	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	2.4	1.6	-1.0	-0.4	1.1	1.4	1.2	1.3	0.4	1.2	1.0
Falls in the last year	2.4	3.2	11.2	1.4	-1.3	-1.5	1.1	2.4	3.3	1.8	1.0	1.3	1.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	-0.8	-0.1	-0.5	1.1	0.4	-1.0	0.3	1.0	1.0	0.0
Number of live births	0.9	1.2	4.3	1.1	-1.0	-0.4	-0.6	0.7	1.6	0.0	2.1	-0.5	1.3
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	8.1	1.6	-2.0	-1.9	2.9	2.7	1.6	2.3	1.0	2.6	1.7
Pulse rate	0.9	1.5	4.5	-0.3	1.3	1.8	-1.3	-1.3	-0.8	-2.1	-0.2	-1.1	-0.3
Happiness	0.6	0.7	1.7	-0.4	-0.3	-0.3	-1.3	-1.0	-1.0	-1.0	0.2	-1.3	0.3
Noisy workplace	0.2	0.3	0.9	-0.8	-0.1	-0.5	0.4	0.4	0.3	1.0	-0.5	0.5	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.0	-1.3	0.3	-0.6	-0.2	-0.0	-1.0	-0.5	-1.7	-0.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.9	0.0	0.7	-0.5	0.6	0.3	0.6	0.5	1.4	0.7	0.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	-1.2	1.2	0.5	-0.9	0.2	0.2	-0.4	0.2	-0.9	-1.3
Asthma	0.6	1.1	2.7	0.2	0.3	0.4	-1.5	-1.2	-0.7	-1.6	0.2	-1.6	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	4.1	0.8	-1.5	-1.1	-0.1	-0.4	0.7	1.0	-1.2	-0.0	2.0
Medication: Cholesterol lowering	1.2	1.9	4.8	0.9	-0.4	-0.3	1.4	1.2	1.8	2.2	-1.2	1.4	1.9
Depression (self-reported)	1.2	1.4	4.8	-0.5	1.3	0.8	-1.2	-0.9	-2.2	-1.5	0.0	-1.0	-1.2
Medication: Lansoprazole	0.3	0.4	1.0	-0.6	-0.9	-0.8	-0.4	-0.0	1.0	-0.0	0.9	-0.4	0.2
Prospective memory result	0.8	1.0	7.3	0.4	0.4	0.5	0.6	1.0	0.5	0.2	2.7	0.6	-0.6
Lung cancer (father)	0.6	0.7	3.0	-0.4	0.5	0.7	-0.1	0.8	1.7	0.6	1.3	-0.1	0.9
Illnesses of mother	0.7	0.9	2.2	-0.4	1.5	0.9	-1.3	-0.8	0.7	0.1	-0.4	-1.2	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	5.2	1.1	-1.8	-2.0	2.1	2.3	0.6	1.6	0.9	1.9	1.0
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.7	0.8	0.7	-0.1	0.3	-0.1	-0.7	0.9	-0.1	-0.9
Impedance of arm (left)	0.5	2.4	8.9	0.9	1.0	1.1	1.8	3.0	1.7	1.4	-0.8	1.9	-0.6
Arm fat mass (right)	1.0	4.2	6.9	2.4	-1.1	-2.0	2.5	2.6	2.0	2.2	0.7	2.4	1.5
Trunk predicted mass	0.1	0.7	1.8	-0.3	-0.6	-1.2	1.3	0.9	-0.2	0.4	-0.5	1.1	0.6
Standing height	0.5	5.2	17.2	0.3	-0.2	-1.0	3.7	4.2	1.2	1.9	-1.6	3.5	-0.1
Length of working week for main job	2.0	2.2	9.3	1.7	-0.8	-1.0	1.4	0.7	3.0	1.3	1.2	1.4	0.4
Exposure to tobacco smoke at home	0.8	0.9	2.1	0.6	1.4	1.3	-0.5	0.9	1.2	-0.3	1.5	-0.5	-0.6
Breastfed as a baby	0.5	0.7	4.6	-2.1	-0.2	-0.5	-0.2	0.1	-0.1	0.2	0.7	-0.1	-1.1
Tense / ‘highly strung’	1.9	3.2	11.6	0.0	-0.2	-0.0	2.0	3.4	1.7	2.1	1.9	2.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.1	-1.5	0.9	0.9	0.3	0.9	-0.5	-0.0	-0.2	0.1	-1.0
Hair/balding pattern: Pattern 4	0.1	0.3	1.7	-0.1	0.3	-0.0	-0.6	-0.4	-1.3	-0.6	0.1	-0.4	-0.1
Birth weight of first child	1.2	2.2	13.0	1.4	0.2	-0.4	1.3	3.6	1.6	1.1	0.6	1.2	0.3
Peak expiratory flow (PEF)	0.4	0.9	2.7	1.6	-1.6	-0.6	0.2	-0.4	-1.5	-0.3	0.6	-0.3	0.2
Pulse wave reflection index	0.3	0.3	0.7	0.1	0.8	0.5	0.6	0.6	0.7	0.3	0.8	0.6	0.0
Ever highly irritable/argumentative for 2 days	2.3	2.8	10.2	0.7	-0.2	-0.1	1.8	1.9	3.2	2.3	0.7	1.7	1.1
Loud music exposure frequency	0.6	0.7	1.5	0.1	-1.1	-1.1	-1.2	0.1	1.2	-0.6	-0.7	-0.9	0.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	6.1	0.5	0.3	-0.1	-0.0	-0.0	-2.5	-0.8	-0.2	-0.1	-1.0
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	4.7	1.0	-2.1	-2.2	1.1	1.4	1.1	1.3	-0.0	1.2	1.2
Blood clot in the leg (DVT)	1.6	2.1	6.2	2.0	-0.5	-0.7	1.4	1.5	1.3	0.9	2.5	1.6	-0.0
Medication: Paracetamol	0.4	0.7	2.7	0.4	0.1	0.4	-1.1	-1.6	-0.0	-0.7	-0.6	-1.3	-0.5
Headache pain in last month	0.2	0.3	1.2	-0.0	-0.5	-0.6	0.6	0.3	-0.4	1.1	-0.0	0.5	0.8
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	5.8	-1.2	-0.1	-0.2	-2.1	-2.3	-2.1	-2.4	0.6	-2.1	-1.8
Glaucoma (self-reported)	2.4	2.9	7.2	0.2	0.2	0.4	-1.6	-2.7	-1.8	-2.1	-2.3	-1.5	-1.7
Gout (self-reported)	0.7	0.9	6.3	-0.9	0.0	-0.7	-0.1	-0.6	-1.1	0.2	-2.5	-0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	6.5	-0.2	0.3	0.1	0.7	2.6	0.6	1.3	0.1	0.7	1.2
Medication: Amlodipine	0.6	0.8	2.1	1.0	1.2	0.9	0.4	0.7	1.1	0.5	1.4	0.4	-0.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	5.2	0.9	0.8	1.6	-0.0	0.5	0.0	-0.3	2.3	0.1	-0.8
Birth weight	0.5	1.1	2.5	0.5	-1.4	-1.3	1.2	1.4	1.6	0.4	0.2	1.2	0.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	0.7	-0.9	-0.5	-0.7	0.5	0.1	-0.0	-0.6	-0.7	-0.1
High blood pressure (siblings)	1.0	1.4	4.7	1.1	0.8	0.9	0.9	1.8	0.9	0.8	2.2	0.8	-0.7
Forced vital capacity (FVC), Best measure	0.7	2.7	7.5	0.6	-1.4	-1.7	2.3	2.7	1.1	1.8	0.7	2.1	0.6
Body fat percentage	1.1	4.2	11.4	2.4	-0.6	-1.2	2.4	3.4	2.2	2.3	0.3	2.4	0.8
Leg fat percentage (right)	0.6	2.2	5.4	1.8	-0.2	-0.9	1.6	2.3	1.9	1.8	0.1	1.6	0.7
Arm fat-free mass (right)	0.1	0.6	1.7	-0.4	-0.9	-1.3	1.0	0.4	-0.7	0.0	-0.8	0.7	0.7
Exposure to tobacco smoke outside home	0.7	0.9	3.7	-1.2	0.3	0.1	0.0	0.0	1.1	1.0	-1.4	0.2	1.9
Comparative body size at age 10	0.4	1.1	3.3	0.4	-1.8	-1.8	1.0	0.5	0.2	0.9	0.4	0.9	1.2
Number of full brothers	0.9	1.2	4.2	0.2	1.3	1.5	-0.5	-0.2	-0.9	-0.6	-1.3	-0.8	-2.1
Worry too long after embarrassment	0.8	1.3	4.8	-1.2	0.0	0.4	0.5	2.2	2.0	1.1	0.5	0.4	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.7	-0.7	0.9	1.0	0.2	1.3	0.4	-0.1	0.1	0.0	-1.2
Wheeze or whistling in the chest in last year	0.4	0.7	2.2	1.5	-0.9	-0.6	-0.3	0.9	1.4	-0.1	0.4	-0.2	0.4
Number of children fathered	1.4	1.6	3.9	-0.8	1.2	2.0	-1.9	-1.1	-0.2	-0.9	-0.4	-1.9	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	1.1	-1.0	-0.7	0.8	1.4	0.2	0.4	-0.7	0.8	0.8
Age at first live birth	0.4	0.7	3.5	-0.1	0.7	0.1	0.9	-0.1	-0.8	-0.1	0.0	1.0	-1.9
Pulse wave peak to peak time	0.5	0.6	1.2	-0.5	-1.0	-1.0	0.5	0.1	0.2	1.0	-1.1	0.5	1.1
Health satisfaction	1.0	1.3	4.7	1.2	-0.9	-0.4	0.6	1.8	0.6	0.7	2.2	0.4	0.7
Shortness of breath walking on level ground	1.0	1.1	3.6	0.8	-0.4	-0.1	1.3	1.4	1.2	1.9	0.3	1.3	0.4
Qualifications: College or University degree	0.3	1.1	3.3	0.0	-0.1	-0.7	-0.1	-1.4	-1.8	-0.8	-1.7	-0.4	-1.2
Eye problems/disorders: None of the above	0.5	0.6	1.2	-0.7	1.1	1.1	0.9	0.5	-0.2	0.3	0.9	0.9	-0.5
Mouth/teeth dental problems: Loose teeth	2.2	2.6	7.2	-0.2	-2.7	-2.1	1.6	1.2	0.9	1.6	1.2	1.6	1.6
Emphysema/chronic bronchitis	0.3	0.4	1.5	-0.2	0.4	-0.2	-0.7	-0.7	0.4	-0.5	-1.2	-0.5	-0.7
Medication for pain relief, constipation, heartburn	0.7	1.1	3.6	-0.6	1.5	1.0	-0.3	-0.3	-1.9	-1.0	-0.1	-0.4	-1.7
Neck or shoulder pain in last month	0.7	1.0	3.8	1.2	-1.2	-1.9	0.5	1.4	0.7	0.3	-0.5	0.6	0.1
Medication: Blood pressure	1.9	3.3	6.1	1.5	-0.6	-0.6	2.4	2.5	2.1	2.2	0.7	2.4	1.6
Angina (self-reported)	0.6	0.7	1.5	-0.6	0.3	-0.2	-0.9	-1.1	-1.0	-1.2	-1.2	-0.8	-0.4
Migraine (self-reported)	0.6	0.7	1.8	-0.8	0.2	0.9	-0.9	-0.7	-0.5	0.0	1.3	-1.0	1.3
Medication: Ibuprofen	0.7	0.9	3.0	0.9	-0.9	-0.3	0.7	0.5	0.7	1.4	-0.3	0.9	1.7
Medication: Allopurinol	0.3	0.4	1.2	0.2	-0.3	-0.6	0.7	0.0	0.1	0.8	-0.8	0.7	1.1
Medication: Omeprazole	1.2	1.4	5.0	0.3	-0.0	0.1	1.2	2.0	2.2	1.2	0.3	1.3	0.9
Medication: Seretide 50 evohaler	0.2	0.2	1.1	0.5	-0.3	0.5	0.0	0.6	1.1	-0.2	-0.1	0.1	-0.3
Mean time to correctly identify matches	0.6	1.2	2.2	-1.4	-0.4	-0.6	-1.2	-0.4	-1.0	-1.3	-1.1	-1.2	-1.5
Heart disease (mother)	2.1	2.6	9.3	0.8	-0.7	-0.5	1.8	2.2	3.1	1.4	0.6	1.9	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.7	-0.3	-0.1	-0.0	-0.7	-1.2	0.1	-1.1	-1.3	-0.8	0.3
Whole body fat mass	1.1	4.6	10.8	2.4	-1.0	-1.8	2.8	3.3	1.9	2.4	0.3	2.6	1.2
Leg fat mass (right)	0.7	2.6	4.4	1.8	-0.7	-1.5	2.1	2.1	1.6	1.9	0.2	1.9	1.0
Arm predicted mass (right)	0.2	0.8	2.0	-0.5	-0.9	-1.4	1.3	0.6	-0.3	0.5	-0.9	1.0	1.0
Pulse rate, automated reading	0.1	0.4	0.8	0.9	-0.6	-0.8	0.2	-0.9	0.3	-0.3	-0.9	0.5	0.5
Alcohol intake frequency.	0.6	1.3	3.4	-0.2	0.8	1.4	-1.0	-0.8	-0.0	-1.2	1.7	-1.0	-1.9
Comparative height size at age 10	1.1	6.3	20.6	-0.1	-0.5	-0.7	3.6	4.5	1.9	2.5	-1.9	3.7	0.6
Number of full sisters	0.5	0.6	1.8	-1.4	-0.1	0.9	-0.6	-1.3	-0.6	-0.3	-0.2	-0.5	0.3
Suffer from ‘nerves’	0.3	0.4	2.1	-0.7	0.2	0.6	0.3	1.4	0.6	0.2	0.6	0.3	0.2
Overall health rating	0.2	0.5	1.9	1.4	-0.4	0.1	-0.8	0.4	0.4	-0.8	1.1	-0.7	-0.1
Chest pain or discomfort	0.6	0.8	4.6	2.1	-1.3	-0.7	-0.0	-0.2	0.4	-0.3	1.1	0.0	-0.1
Had major operations	0.3	0.4	1.9	-0.2	0.3	0.2	-0.3	0.2	0.1	-0.2	1.4	-0.3	-1.1
Age at last live birth	0.4	0.6	1.6	0.5	-0.6	-1.1	1.3	-0.2	0.3	0.2	-0.5	1.2	-0.5
Family relationship satisfaction	0.3	0.4	1.2	1.0	-0.5	-0.9	-0.4	0.2	-0.4	-0.6	1.1	-0.4	0.2
Leg pain on walking	1.0	1.3	5.0	0.5	-0.2	0.2	0.5	1.5	1.9	1.1	2.2	0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.0	1.7	-1.3	-1.1	0.8	0.4	-0.4	0.9	-1.1	0.7	0.5
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.3	-1.5	-1.0	-1.4	1.0	0.7	0.4	1.5	-1.5	0.9	0.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.5	0.2	0.5	0.8	-0.9	-0.2	-0.2	-1.1	-1.6	-0.9	-0.8
Medication: Aspirin	2.1	2.7	6.1	1.0	-1.1	-1.0	1.8	2.5	2.1	2.1	0.1	1.9	1.5
Supplements: Vitamin C	1.2	1.5	3.4	-0.5	-1.4	-1.0	1.5	1.8	1.5	0.8	0.9	1.4	0.1
Knee pain experienced in last month	1.6	2.5	6.7	1.6	-1.0	-1.4	1.5	2.6	0.7	2.0	1.0	1.7	1.4
Hypertension (Self-reported)	1.7	4.7	7.4	2.5	-0.8	-0.9	2.6	2.6	2.7	2.5	1.3	2.6	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.6	-0.7	-0.8	-0.8	-0.1	1.2	1.0	0.3	0.7	0.0	0.8
Illnesses of father: Heart disease	1.3	1.7	3.4	1.2	-1.8	-1.5	1.4	0.4	-0.7	1.6	0.9	1.4	1.5
Illnesses of siblings: Diabetes	0.8	1.0	3.1	0.7	-1.2	-1.0	1.2	1.8	0.8	1.1	0.3	0.8	0.5
Smoking status: Previous	0.4	0.5	1.7	-0.8	-0.2	-0.7	0.3	0.7	1.3	0.9	-0.6	0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.7	0.0	-0.3	-0.9	1.6	1.4	0.1	1.3	-0.9	1.5	-0.6
Whole body fat-free mass	0.2	1.1	2.7	0.3	-0.9	-1.6	1.6	1.1	0.1	0.7	-0.1	1.3	1.0
Leg fat-free mass (right)	0.3	1.7	4.6	1.3	-1.4	-2.1	1.7	1.3	0.3	1.0	0.6	1.4	1.1
Arm fat percentage (left)	0.7	2.8	6.0	2.3	-0.4	-1.2	1.8	2.5	1.8	2.0	0.2	1.7	1.3
Average weekly red wine intake	0.2	0.3	0.7	0.2	0.8	0.3	0.7	0.8	0.1	0.6	-0.1	0.7	0.7
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.0	-1.1	1.2	1.1	-0.4	1.7	-0.1	0.2	1.7	-0.3	0.2
Mood swings	0.4	0.8	3.1	-0.2	-1.1	-0.7	-0.3	1.8	1.3	0.3	0.8	-0.1	0.3
Loneliness, isolation	0.3	0.4	1.9	0.8	0.3	0.7	-0.1	0.5	0.8	0.2	1.4	-0.1	0.1
Long-standing illness, disability or infirmity	1.0	1.5	5.1	2.3	-1.4	-0.9	-0.4	0.9	1.1	-0.6	1.9	-0.3	0.6
Ever had bowel cancer screening	0.7	0.8	2.1	-0.0	0.7	1.4	-0.5	1.4	1.1	0.1	1.4	-0.2	-0.5
Diabetes diagnosed by doctor	0.4	0.7	3.4	0.5	-0.8	-1.4	-0.2	-0.3	-0.0	0.1	-1.8	-0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	4.6	0.4	-1.3	-1.6	1.2	1.6	1.3	2.1	-0.5	1.3	1.2
Friendships satisfaction	0.4	0.5	1.3	-0.7	0.5	0.9	-1.1	0.5	-0.5	-0.1	0.6	-1.1	0.3
Qualifications: nursing, teaching	0.7	1.1	2.6	0.3	-0.7	-1.1	1.1	1.1	-0.2	1.2	-0.8	1.4	1.6
Commuting to job workplace: Walk	2.2	2.3	5.1	0.6	1.9	2.2	-1.9	-1.0	0.1	-2.3	0.3	-1.9	-1.2
Eye problems/disorders: Cataract	0.8	0.9	3.2	1.5	-1.8	-1.2	0.3	0.8	1.0	0.2	0.1	0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.0	0.9	-2.2	-1.9	0.2	0.6	0.5	0.5	-0.6	0.2	1.4
Medication for cholesterol	0.6	1.0	3.3	0.0	-0.6	-1.1	0.8	0.2	-0.5	0.8	-1.5	0.9	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	4.5	-0.3	-1.0	-1.5	1.4	1.1	2.1	1.1	-0.3	1.6	1.3
Back pain experienced in last month	0.9	1.4	5.3	0.3	-2.3	-2.2	-0.2	-1.3	-0.1	-1.0	-0.2	-0.1	-0.7
Mineral and other dietary supplements	0.6	0.8	4.0	0.8	0.9	0.5	-0.4	-2.0	0.1	0.2	0.7	-0.4	-1.1
Breast cancer (self-reported)	0.8	1.0	3.3	-0.4	-1.8	-1.7	0.6	-0.5	-0.9	0.6	-0.8	0.4	1.0
Asthma (self-reported)	0.3	0.6	1.6	0.3	-0.1	0.2	-1.1	-0.9	-0.2	-1.2	0.3	-1.3	-0.7
Osteoporosis (self-reported)	0.5	0.6	1.7	-0.3	0.3	0.3	-0.8	-1.0	-0.5	-1.3	-0.6	-0.9	-1.1
Osteoarthritis (self-reported)	0.6	0.8	2.3	0.3	0.9	0.5	-0.3	1.3	0.7	-0.9	-1.1	0.0	-1.5
Medication: Aspirin	2.4	3.2	6.5	1.2	-1.5	-1.4	2.0	2.5	1.9	2.3	-0.2	2.0	1.7
Medication: Gliclazide	1.0	1.1	4.0	-0.7	0.3	-0.2	-0.4	-1.6	-1.9	-0.1	-2.0	-0.4	-0.4
Illnesses of father: None of the above (group 1)	1.9	2.4	4.6	-1.2	1.9	1.6	-1.9	-1.3	-0.4	-2.1	-1.4	-2.0	0.0
Smoking status: Current	1.5	2.4	9.5	0.8	-2.4	-3.1	1.1	0.4	1.1	0.9	0.1	1.1	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.2	-1.8	-0.7	-0.7	-0.8	0.3	-0.7	-1.0	0.8	-0.9	-1.5
Whole body water mass	0.2	1.1	2.9	0.3	-1.0	-1.7	1.7	1.1	0.1	0.7	-0.1	1.4	0.9
Leg predicted mass (right)	0.3	1.6	4.4	1.2	-1.4	-2.1	1.6	1.1	0.2	0.9	0.6	1.4	1.1
Arm fat mass (left)	0.8	3.2	6.5	2.1	-0.8	-1.6	2.2	2.5	1.7	2.0	0.3	2.0	1.4
Number of self-reported non-cancer illnesses	0.2	0.3	2.0	0.1	-0.6	-0.2	-0.1	-0.0	0.1	-0.5	-0.4	0.1	-1.4
Average weekly champagne plus white wine intake	0.4	0.5	1.3	0.9	-0.6	-0.2	1.1	0.4	0.1	0.2	-1.0	1.1	0.6
Miserableness	0.1	0.2	1.2	-0.5	-0.0	0.5	-0.3	1.1	-0.4	-0.0	-0.4	-0.2	0.1
Guilty feelings	0.5	0.8	2.3	0.4	1.3	1.4	-0.4	0.8	0.0	-0.8	0.8	-0.2	-1.5
Wears glasses or contact lenses	1.6	1.8	3.8	-1.1	0.7	0.9	-1.9	-1.7	-1.0	-1.9	-0.8	-1.7	-0.9
Ever taken oral contraceptive pill	1.5	1.7	4.2	1.9	0.7	0.9	1.2	-0.1	1.0	1.9	0.3	1.2	2.0
Hearing aid user	0.2	0.2	0.8	0.5	-0.3	0.3	0.4	0.3	-0.8	-0.0	0.4	0.2	-0.9
Mother’s age at death	0.3	0.3	1.0	-0.1	-1.0	-0.8	0.6	0.1	-0.0	-0.0	0.9	0.7	-0.0
Financial situation satisfaction	0.7	0.9	5.8	0.1	0.5	1.2	-0.5	0.3	0.2	0.5	2.4	-0.6	0.5
Tinnitus: Yes, now most or all of the time	1.1	1.2	4.5	1.1	-2.1	-2.0	0.6	0.1	0.1	1.3	-0.6	0.5	0.1
Commuting to job workplace: Public transport	0.9	1.1	3.5	0.4	-1.0	-1.1	1.8	-0.3	0.9	0.5	-0.3	1.9	0.2
Eye problems/disorders: Glaucoma	2.2	2.6	6.4	-0.2	0.1	0.0	-1.4	-2.2	-2.0	-1.9	-2.5	-1.3	-1.7
Medication: Blood pressure	0.4	0.8	4.5	0.4	0.2	0.2	0.5	0.7	1.4	0.5	2.1	0.5	-0.5
Pain type(s) experienced in last month: Hip pain	1.2	1.6	5.2	-1.0	0.0	0.5	-2.3	-0.5	-0.2	-1.9	0.5	-2.2	-0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.8	-1.3	-1.1	-0.9	0.1	1.2	-0.0	-0.1	-0.8	-0.0	0.9
High cholesterol (Self-reported)	0.4	0.7	2.5	0.4	0.3	0.7	0.5	1.4	1.6	0.8	-1.0	0.3	0.1
Medication: Bendroflumethiazide	0.7	1.0	2.3	0.4	1.2	1.4	-0.9	-0.8	-0.1	-1.2	1.5	-0.7	-1.2
Medication: Paracetamol	0.2	0.3	1.0	0.2	0.3	1.0	-0.4	-0.8	0.5	0.1	0.6	-0.5	-0.0
Medication: Lisinopril	1.8	2.4	7.7	1.5	-0.0	0.1	1.4	1.4	2.8	1.6	0.8	1.4	2.2
Medication: Atorvastatin	0.1	0.2	0.7	-0.3	0.5	0.9	-0.2	-0.2	0.5	0.3	0.4	-0.3	0.1
Illnesses of father: High blood pressure	3.0	3.7	7.7	1.8	-1.9	-1.3	2.4	1.4	1.3	2.8	0.2	2.6	2.2
Alcohol drinker status: Never	1.1	1.3	5.4	-0.7	1.0	1.3	-1.0	0.5	1.1	-0.6	2.3	-1.0	-0.6
Ever smoked	1.0	1.7	5.5	1.2	-1.5	-2.3	1.0	0.8	1.3	0.9	-0.9	0.9	1.5
Basal metabolic rate	0.3	1.6	3.6	0.9	-1.1	-1.9	1.9	1.4	0.3	1.0	-0.1	1.6	1.1
Leg fat percentage (left)	0.5	1.7	4.6	2.1	0.1	-0.5	1.2	2.1	1.5	1.5	0.3	1.2	0.3
Arm fat-free mass (left)	0.3	1.4	3.3	0.6	-1.4	-1.7	1.8	1.3	0.3	0.9	0.1	1.5	0.8
Number of operations (self-reported)	3.2	4.7	9.4	2.9	-2.2	-1.6	1.7	2.4	3.1	1.9	2.0	1.7	1.7
Average weekly beer plus cider intake	0.7	1.1	2.8	1.1	-0.8	-1.2	0.1	0.9	1.1	1.6	0.0	-0.1	1.7
Irritability	0.4	0.8	3.9	-2.0	0.0	-0.2	0.2	1.6	0.4	0.8	0.1	0.2	-0.3
Risk taking	1.5	2.2	12.1	1.4	-0.4	0.4	1.4	1.3	1.4	1.0	3.5	1.1	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	0.0	-0.7	-0.9	-0.2	-0.9	-0.8	-0.4	-0.5	-0.2	0.6
Fractured/broken bones in last 5 years	1.0	1.2	4.3	1.4	-0.4	-0.5	-0.0	0.9	1.8	0.7	2.1	0.1	1.1
Age started oral contraceptive pill	0.9	1.1	2.2	-1.5	0.7	0.8	-1.2	-0.9	-0.2	-1.4	0.8	-1.0	-1.4
Diastolic blood pressure, automated reading	3.0	9.2	16.9	4.1	-1.8	-1.9	3.4	3.5	4.1	3.3	2.2	3.4	1.1
Ever depressed for a whole week	0.9	1.1	3.1	-1.1	0.3	0.4	-1.7	-0.8	-0.6	-1.2	-0.8	-1.8	0.4
Unable to work because of sickness or disability	1.4	1.8	4.1	1.0	0.9	0.9	-2.0	-0.2	1.4	-1.3	1.8	-2.0	0.8
Commuting to job workplace: Cycle	1.9	2.3	6.7	-0.2	1.0	0.4	-1.3	-1.8	-2.1	-1.6	-1.3	-1.1	-2.6
Myopia	1.2	1.7	4.8	-1.2	0.5	0.7	-1.7	-0.8	-0.5	-2.2	1.3	-1.6	-1.3
Vascular/heart problems diagnosed by doctor	1.7	4.7	7.3	-2.6	0.9	1.2	-2.7	-2.5	-2.6	-2.4	-1.0	-2.7	-1.8
Cholesterol lowering medication	0.6	0.9	1.9	-0.4	0.3	0.9	-1.1	-1.1	-0.2	-1.3	-0.5	-1.2	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	5.6	-0.2	-0.8	-0.5	1.6	2.2	2.4	1.8	0.9	1.7	0.9
Pain experienced in last month	3.2	5.3	8.9	-2.2	3.0	2.9	-1.9	-2.6	-2.1	-2.3	-1.5	-2.0	-2.0
Supplements: Calcium	0.3	0.3	1.5	-0.3	-0.6	0.3	0.3	0.0	-0.3	-0.2	1.2	0.4	0.6
Basal cell carcinoma (self-reported)	0.5	0.5	1.7	0.1	-0.1	-0.2	-1.1	-0.8	-0.6	-1.0	-0.8	-1.3	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.7	0.2	0.3	-0.1	-0.3	0.8	1.3	-0.0	-0.4	-0.3	0.0
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	6.1	2.4	-0.7	-0.7	1.6	1.5	1.3	1.1	2.5	1.8	-0.1
Heart disease (siblings)	0.6	0.7	1.9	-0.3	0.9	1.2	-0.3	0.2	-1.3	-0.3	-1.2	-0.5	-1.4
Alcohol drinker status: Previous	0.9	1.1	2.2	1.3	0.1	0.7	-1.5	-1.4	-0.2	-1.0	1.2	-1.3	-0.4
Pack years of smoking	0.5	0.7	2.3	0.5	-0.3	0.1	-1.0	-0.6	-1.1	-0.6	0.6	-1.0	-1.5
Impedance of whole body	0.4	2.3	7.8	0.9	1.0	1.3	1.6	2.8	1.6	1.2	-0.8	1.7	-1.3
Leg fat mass (left)	0.6	2.3	4.5	1.9	-0.4	-1.3	1.9	2.1	1.4	1.8	0.4	1.8	0.7
Arm predicted mass (left)	0.3	1.3	3.6	0.4	-1.4	-1.9	1.6	1.1	0.2	0.8	-0.1	1.4	1.0