Best TWAS P=1.24e-39 · Best GWAS P=4.19e-70 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | ABHD17AP6 | 0.15 | -0.01 | lasso | 6 | -0.01 | 6.9e-01 | -3.7 | -5.6 | 2.0e-08 | 0.20 | 0.03 | 0.09 | FALSE |
| 2 | GTEx | Colon Transverse | DHRS7B | 0.10 | 0.09 | lasso | 3 | 0.07 | 2.3e-04 | 4.5 | 5.5 | 4.1e-08 | -0.15 | 0.23 | 0.46 | FALSE |
| 3 | GTEx | Esophagus Mucosa | TMEM11 | 0.20 | 0.00 | lasso | 7 | 0.01 | 9.3e-02 | -5.8 | -6.6 | 3.5e-11 | 0.10 | 0.08 | 0.12 | TRUE |
| 4 | GTEx | Esophagus Muscularis | C17orf103 | 0.16 | 0.06 | lasso | 5 | 0.06 | 2.1e-04 | 8.4 | -9.0 | 2.6e-19 | 0.19 | 0.31 | 0.03 | FALSE |
| 5 | GTEx | Lung | C17orf103 | 0.08 | 0.01 | enet | 11 | 0.04 | 6.6e-04 | -10.6 | -12.1 | 1.8e-33 | 0.43 | 0.16 | 0.48 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | C17orf103 | 0.11 | 0.02 | enet | 15 | 0.07 | 1.0e-06 | -5.0 | -10.6 | 2.3e-26 | 0.30 | 0.38 | 0.08 | TRUE |
| 7 | GTEx | Skin Sun Exposed Lower leg | TMEM11 | 0.08 | 0.08 | lasso | 3 | 0.06 | 9.1e-06 | -5.8 | -5.8 | 6.9e-09 | 0.06 | 0.85 | 0.02 | FALSE |
| 8 | GTEx | Testis | C17orf103 | 0.15 | 0.21 | enet | 4 | 0.19 | 7.1e-09 | 8.5 | -9.6 | 5.6e-22 | 0.16 | 0.98 | 0.00 | TRUE |
| 9 | GTEx | Thyroid | DHRS7B | 0.17 | 0.02 | enet | 22 | 0.11 | 1.2e-08 | 4.5 | 9.4 | 3.3e-21 | -0.17 | 0.84 | 0.02 | TRUE |
| 10 | GTEx | Thyroid | KCNJ12 | 0.36 | 0.23 | lasso | 5 | 0.25 | 2.9e-19 | 11.0 | 13.2 | 1.2e-39 | -0.48 | 1.00 | 0.00 | TRUE |
| 11 | METSIM | Adipose | MAP2K3 | 0.08 | 0.02 | blup | 211 | 0.03 | 6.0e-05 | 7.9 | -9.6 | 5.9e-22 | 0.36 | 0.19 | 0.70 | FALSE |
| 12 | NTR | Blood | C17orf103 | 0.02 | 0.02 | lasso | 2 | 0.02 | 1.6e-07 | 8.4 | -9.1 | 8.9e-20 | 0.14 | 0.98 | 0.00 | TRUE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | C17orf103 | 0.16 | 0.05 | enet | 24 | 0.12 | 8.7e-16 | 8.4 | -5.6 | 1.8e-08 | 0.08 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C17orf103 | 0.03 | 0.04 | lasso | 1 | 0.04 | 7.9e-08 | 8.4 | -8.4 | 3.0e-17 | 0.12 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C17orf103 | 0.05 | 0.04 | lasso | 3 | 0.02 | 5.4e-03 | 8.4 | -8.1 | 5.6e-16 | 0.11 | 0.04 | 0.34 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C17orf103 | 0.13 | 0.14 | lasso | 1 | 0.11 | 2.9e-05 | 8.4 | -8.4 | 3.0e-17 | 0.12 | 0.18 | 0.14 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf103 | 0.08 | 0.01 | blup | 44 | 0.01 | 3.2e-02 | 8.4 | -8.6 | 8.3e-18 | 0.29 | 0.04 | 0.29 | FALSE |