Hub : Genes

ABHD17AP6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.1520 0.0630 6.7e-03 -0.008 NA -0.007 NA -0.007 8.1e-01 NA 7.4e-01 NA 6.9e-01
2 GTEx Nerve Tibial 0.0794 0.0365 3.6e-03 0.015 NA 0.015 NA 0.012 2.8e-02 NA 2.8e-02 NA 4.2e-02
3 ROSMAP Brain Pre-frontal Cortex 0.1474 0.0364 9.5e-10 0.132 0.092 0.129 0.119 0.128 1.2e-16 6.5e-12 3.2e-16 4.8e-15 3.5e-16

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.0 0.0 0.0 -0.0 0.0 0.0
Bipolar Disorder or Schizophrenia 0.2 0.6 1.6 -0.4 0.1 -1.3
Depressed Affect (Nagel 2018) 0.1 0.3 0.5 -0.0 0.6 -0.7
Depression (Nagel 2018) 0.3 0.4 0.6 -0.8 -0.7 -0.2
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.2 -1.5 -0.6 -0.4
Neuroticism (Nagel 2018) 0.1 0.2 0.3 -0.0 0.5 -0.5
Schizophrenia (2018) 0.5 1.1 2.9 -0.5 0.3 -1.7
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 1.0 0.6 0.0
Worry (Nagel 2018) 0.5 1.0 1.5 0.5 1.2 -1.1
Alzheimer’s Disease (in mother) 2.2 2.6 3.4 1.1 1.9 -1.8
Alzheimer’s Disease (in father) 1.1 1.2 2.3 -1.5 1.0 -0.6
Alzheimer’s Disease (including proxy) 2.4 3.4 6.3 -0.3 2.5 -2.0
Crohns Disease (2017) 0.1 0.3 0.3 0.6 0.4 -0.6
Irritable Bowel Disease (IBD) 0.5 1.3 1.8 0.8 1.1 -1.4
Ulcerative Colitis (UC) 0.5 1.0 1.5 1.0 1.2 -0.7
Major Depression (MDD) 1.6 2.0 3.3 0.8 -1.8 1.4
Reaction Time 0.9 1.7 2.4 -1.6 -0.6 -1.5
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.4 -1.6 -0.9 -0.5
Breast Cancer 0.1 0.2 0.3 -0.2 -0.4 0.6
Ovarian Cancer 2.6 3.5 4.5 1.5 -2.1 1.9
Prostate Cancer 0.3 0.4 0.6 0.7 -0.8 0.3
Age at First Birth 0.5 0.7 1.7 -1.3 -0.2 0.6
Bipolar Disorder (2011) 0.3 0.3 0.5 0.6 0.0 -0.7
Body Mass Index (BMI) (2010) 1.0 1.4 2.4 1.0 1.6 -1.0
Coronary Artery Disease (CAD) 0.3 0.4 0.9 0.9 -0.5 0.1
Crohns Disease (2012) 0.0 0.1 0.1 0.1 -0.1 -0.4
Mean Putamen Volume 0.6 0.7 1.7 0.5 0.5 -1.3
Fasting Glucose 1.9 2.3 3.3 -1.8 -1.6 1.0
HbA1C 2.4 2.7 4.5 1.6 -2.1 1.0
HDL Cholesterol 1.0 1.7 2.8 -1.7 -0.9 1.2
LDL Cholesterol 0.9 1.4 2.3 1.1 1.5 -0.8
Lupus 0.2 0.3 0.6 -0.3 0.8 -0.4
Neuroticism (2016) 0.3 0.4 1.0 1.0 -0.3 -0.0
Primary Biliary Cirrhosis 1.0 1.4 2.6 1.6 1.0 -0.8
Rheumatoid Arthritis 1.8 2.5 5.4 2.3 1.0 -1.0
Schizophrenia (2014) 0.6 1.3 2.7 -1.1 -0.1 -1.6
Triglycerides 0.1 0.2 0.4 0.3 -0.3 -0.6
Type 2 Diabetes (T2D) (2012) 2.1 2.4 4.1 0.6 2.0 -1.7
Ulcerative Colitis 0.7 1.1 1.8 0.3 1.1 -1.3
Blood Eosinophil Count 0.0 0.1 0.2 -0.5 -0.4 0.0
Blood Platelet Count 0.4 4.8 8.1 0.6 2.4 -2.8
Blood Red Count 0.3 2.4 7.1 -0.5 -2.7 0.0
Blood White Count 0.2 1.4 2.4 -1.5 -0.0 -1.4
Heel T-Score 0.4 3.3 4.8 -1.3 2.2 -1.8
BMI 1.0 5.7 15.1 3.9 0.5 -1.3
Height 0.6 11.9 31.5 -5.6 -1.2 1.6
Waist Hip Ratio (WHR) 0.6 2.6 3.6 1.7 -1.1 1.9
Systolic Blood Pressure 0.4 1.8 4.0 -2.0 1.1 -0.5
Smoking Status 0.7 1.7 4.3 -0.8 -2.1 0.6
Allergy or Eczema 0.1 0.2 0.3 -0.3 -0.3 0.5
Cardiovascular Disease 0.4 1.3 2.6 -1.6 0.8 -0.9
Hypothyroidism (self reported) 0.4 0.9 2.2 0.7 -0.3 -1.5
Respiratory disease 0.7 1.6 2.7 -0.6 -1.6 1.4
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 0.4 0.1 -0.1
Lung FEV1/FVC ratio 0.2 0.8 1.7 0.4 1.3 -0.8
Lung FVC 0.2 1.2 1.8 1.3 -1.3 -0.3
Neuroticism 0.0 0.1 0.2 0.4 -0.1 -0.1
Chronotype (morning person) 0.1 0.1 0.3 0.2 0.1 -0.5
Hair Pigment 0.0 1.4 2.5 0.5 1.6 -1.2
Tanning 0.1 0.9 1.0 1.0 -0.9 1.0
Hand grip strength (left) 0.6 1.7 3.1 -1.8 -0.2 1.4
Number of treatments/medications taken 0.4 0.7 1.4 0.2 0.9 -1.2
Average weekly spirits intake 0.4 0.4 1.1 1.0 -0.2 0.5
Sensitivity / hurt feelings 0.3 0.5 1.1 1.0 -0.3 0.4
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.6 -0.8 -1.9 0.0
Hearing difficulty/problems: Yes 0.1 0.1 0.2 0.1 -0.4 0.3
Relative age of first facial hair 0.0 0.1 0.1 0.1 -0.3 -0.3
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 3.1 0.0 0.1 -1.8
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.7 -0.6 0.5 -1.3
Ever had hysterectomy (womb removed) 3.2 3.6 3.9 1.8 1.9 -2.0
Systolic blood pressure, automated reading 1.0 2.9 5.8 -0.5 2.4 -1.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 0.9 0.2 1.0 0.8
Angina 1.0 1.3 2.9 0.3 0.9 -1.7
Medication for hormone replacement therapy 1.1 1.2 2.0 -0.8 -1.4 1.0
Vitamin and mineral supplements 0.3 0.5 1.1 -1.0 0.4 -0.4
Supplements: Zinc 2.1 2.3 4.8 -0.4 -1.4 2.2
Medication: Co-codamol 0.7 0.8 1.5 1.2 0.6 -0.7
Medication: Metformin 0.2 0.3 0.5 0.6 0.7 0.1
Diabetes (father) 1.0 1.2 3.4 0.1 0.5 -1.8
Diabetes (mother) 0.4 0.5 0.9 0.6 0.9 -0.5
Severe depression (siblings) 0.8 0.9 2.0 -0.5 -1.4 0.7
Pack years adult smoking proportion 0.8 1.2 2.8 1.7 0.2 -0.8
Impedance of leg (right) 0.1 0.5 1.0 0.7 -0.5 1.0
Leg fat-free mass (left) 0.2 1.0 2.1 -1.5 -0.8 -0.5
Trunk fat percentage 1.0 4.0 8.2 2.9 0.6 -1.8
Hand grip strength (right) 0.2 0.6 1.9 -0.0 -0.1 1.4
Townsend deprivation index at recruitment 1.6 2.2 5.7 2.4 -0.4 0.8
Current tobacco smoking 0.9 1.5 3.5 -0.5 -1.9 0.8
Average weekly fortified wine intake 0.2 0.3 0.8 -0.9 0.2 0.1
Maternal smoking around birth 0.3 0.5 0.8 -0.9 -0.7 0.4
Fed-up feelings 0.3 0.6 1.4 -0.3 -1.2 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.4 0.5 -1.2 0.2
Relative age voice broke 0.1 0.1 0.2 -0.5 0.4 0.0
Taking other prescription medications 0.6 1.0 2.7 0.4 0.1 -1.6
Age when periods started (menarche) 0.4 0.9 2.5 -1.6 0.0 0.3
Bilateral oophorectomy (both ovaries removed) 2.4 2.8 3.6 1.0 1.9 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.4 -1.2 -0.3 -0.6
Tinnitus: Yes, but not now, but have in the past 3.6 3.8 6.3 2.5 1.9 -1.3
Qualifications: CSEs or equivalent 0.3 0.4 1.0 -0.4 -0.4 1.0
Serious illness, injury or assault to yourself 1.2 1.4 1.9 1.2 0.9 -1.4
High blood pressure 0.2 0.5 0.9 -0.6 1.0 -0.4
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.6 -0.4 -1.3 0.9
Multivitamins +/- minerals 0.8 1.0 2.7 1.7 -0.1 0.6
Stomach or abdominal pain in last month 0.6 0.8 1.4 0.7 0.7 -1.2
Supplements: Glucosamine 0.2 0.3 0.7 -0.1 -0.3 0.9
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 2.7 -0.4 -1.6 0.5
Medication: Atenolol 1.5 1.8 3.6 1.1 1.9 -0.8
Medication: Levothyroxine sodium 0.2 0.4 0.6 -0.4 -0.6 -0.8
Sitting height 0.8 5.8 16.4 -4.0 -0.5 -0.9
Chronic bronchitis/emphysema (father) 2.5 2.9 6.1 0.8 1.4 -2.5
High blood pressure (mother) 0.2 0.3 0.5 -0.3 0.6 -0.7
Body mass index (BMI) 1.2 5.1 10.8 3.3 0.6 -2.0
Impedance of leg (left) 0.1 0.5 1.3 1.1 -0.4 0.4
Leg predicted mass (left) 0.2 0.9 1.9 -1.4 -0.8 -0.4
Trunk fat mass 0.5 2.3 4.3 2.1 0.3 -1.6
Waist circumference 0.6 2.3 5.3 2.3 0.1 -1.3
Number of incorrect matches in round 1.6 2.6 5.1 -0.1 1.6 -2.3
Past tobacco smoking 1.2 2.2 5.0 1.3 2.2 -0.1
Alcohol usually taken with meals 0.1 0.1 0.2 -0.4 -0.5 -0.3
Nervous feelings 0.5 0.9 1.4 1.1 -0.3 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.3 -0.1 -1.2 0.3
Hearing difficulty/problems with background noise 0.3 0.5 0.8 0.7 -0.9 0.2
Hair/balding pattern: Pattern 2 1.9 2.4 6.4 -0.9 -2.5 0.1
Had menopause 4.0 5.0 9.2 0.7 3.0 -2.3
Had other major operations 0.3 0.4 1.0 0.4 1.0 0.0
Forced vital capacity (FVC) 0.6 2.3 4.5 -2.1 -1.3 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.1 -0.8 -0.8 -1.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.7 -1.3 -0.1 0.5
Qualifications: None of the above 0.8 1.6 3.0 0.3 1.7 -1.3
Financial difficulties in last 2 years 1.7 2.3 3.6 -0.2 -1.9 1.8
Mouth/teeth dental problems 0.2 0.3 0.7 -0.8 0.5 -0.1
Heart attack 1.0 1.3 3.2 1.8 -0.0 0.8
Allergy 1.2 2.9 6.0 0.5 2.5 -1.5
Pain all over the body in last month 1.3 1.3 3.2 -0.8 -1.8 0.4
Diabetes (self-reported) 0.2 0.3 0.4 0.6 0.6 -0.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.1 3.1 0.0 1.8 -0.6
Medication: Ramipril 0.6 0.8 1.4 -0.3 1.0 -1.2
Medication: Simvastatin 1.4 2.1 3.6 1.0 1.9 -1.2
Fluid intelligence score 1.7 3.6 5.2 -1.6 -2.3 1.7
Illnesses of siblings 0.7 1.0 2.5 0.6 -0.2 1.6
Neuroticism score 0.2 0.5 0.8 0.9 -0.6 -0.6
Weight 0.2 0.8 2.0 0.6 -0.1 -1.4
Impedance of arm (right) 0.3 1.2 2.1 -1.1 0.3 1.5
Arm fat percentage (right) 0.9 3.6 8.5 2.9 0.7 -1.4
Trunk fat-free mass 0.3 1.8 4.5 -2.1 -1.0 -0.0
Hip circumference 0.3 1.2 1.8 1.4 -0.1 -1.3
Time employed in main current job 3.6 4.2 8.5 -0.5 2.9 -1.9
Alcohol intake versus 10 years previously 0.2 0.3 0.4 0.6 -0.3 -0.6
Father’s age at death 0.8 1.1 2.7 0.7 -0.3 1.6
Worrier / anxious feelings 2.4 4.5 6.4 2.5 2.1 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 -0.6 -0.2 -0.5
Falls in the last year 1.0 1.4 2.1 1.4 -1.4 -0.3
Hair/balding pattern: Pattern 3 0.2 0.2 0.4 -0.6 0.5 -0.4
Number of live births 0.7 1.0 1.5 0.7 -1.2 -1.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.1 -1.4 -0.5 0.7
Pulse rate 1.1 1.9 2.3 1.5 1.5 -1.1
Happiness 2.6 3.2 5.7 1.3 -1.4 2.4
Noisy workplace 1.0 1.2 2.0 0.2 1.4 -1.3
Qualifications: A levels/AS levels or equivalent 0.4 1.0 1.7 -1.3 -0.9 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.7 0.5 0.1 -1.3
Mouth/teeth dental problems: Dentures 0.2 0.3 0.8 0.9 -0.2 0.5
Asthma 1.3 2.5 3.6 -1.1 -1.9 1.7
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.3 0.2 -1.1 1.1
Medication: Cholesterol lowering 0.2 0.3 0.6 0.2 0.7 -0.6
Depression (self-reported) 1.4 1.6 2.3 1.5 -0.9 1.3
Medication: Lansoprazole 1.7 2.0 2.8 1.4 1.7 -1.1
Prospective memory result 4.4 5.4 7.8 1.6 2.8 -2.4
Lung cancer (father) 0.3 0.4 1.1 -1.0 -0.2 0.3
Illnesses of mother 0.1 0.1 0.3 -0.0 -0.6 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.8 -1.7 -0.6 0.6
Pulse wave Arterial Stiffness index 0.5 0.6 1.4 -1.2 0.5 -0.2
Impedance of arm (left) 0.2 1.1 1.6 -1.3 0.1 1.3
Arm fat mass (right) 0.6 2.3 4.4 2.1 0.3 -1.6
Trunk predicted mass 0.3 1.6 4.0 -2.0 -0.9 -0.1
Standing height 1.1 11.4 30.9 -5.6 -1.5 1.0
Length of working week for main job 0.7 0.7 1.7 0.3 -1.3 0.7
Exposure to tobacco smoke at home 1.0 1.1 2.7 1.6 -0.8 -0.3
Breastfed as a baby 0.4 0.5 1.2 -1.1 -0.4 -0.5
Tense / ‘highly strung’ 0.4 0.7 1.5 -0.6 -1.2 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.3 1.1 0.1 -0.1
Hair/balding pattern: Pattern 4 0.7 1.6 2.6 -1.1 1.6 -0.9
Birth weight of first child 0.0 0.1 0.1 -0.3 -0.3 0.0
Peak expiratory flow (PEF) 0.1 0.2 0.6 -0.8 -0.1 0.1
Pulse wave reflection index 1.3 1.6 4.9 -2.2 -0.2 -0.0
Ever highly irritable/argumentative for 2 days 2.3 2.8 6.0 -0.8 -2.4 1.3
Loud music exposure frequency 2.4 2.7 4.3 0.6 -2.1 1.8
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 6.7 -2.6 -1.0 0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 0.4 -0.7 0.9
Blood clot in the leg (DVT) 0.2 0.3 0.8 0.1 -0.9 -0.2
Medication: Paracetamol 0.6 1.1 1.7 1.3 -1.2 0.4
Headache pain in last month 0.9 1.5 2.5 0.3 -1.6 1.4
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.1 0.2 -0.4 -0.3
Glaucoma (self-reported) 0.5 0.5 1.0 -1.0 -0.8 0.1
Gout (self-reported) 1.3 1.7 2.4 -1.6 -1.2 -1.1
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.7 -0.4 -0.4 -1.6
Medication: Amlodipine 0.2 0.3 0.6 -0.4 -0.2 0.8
Medication: Ventolin 100micrograms inhaler 0.3 0.3 1.0 -1.0 -0.1 -0.1
Birth weight 1.1 2.4 5.4 0.1 2.3 -1.3
Chronic bronchitis/emphysema (mother) 1.6 1.8 3.7 0.2 -1.9 1.3
High blood pressure (siblings) 1.8 2.6 5.8 -0.6 1.3 -2.4
Forced vital capacity (FVC), Best measure 0.6 2.1 3.7 -1.9 -1.3 1.0
Body fat percentage 1.4 5.4 13.0 3.6 0.6 -1.7
Leg fat percentage (right) 1.8 6.7 16.2 4.0 0.8 -1.8
Arm fat-free mass (right) 0.2 0.9 1.3 -0.9 -0.7 -1.1
Exposure to tobacco smoke outside home 3.9 5.2 13.0 3.6 1.1 -1.2
Comparative body size at age 10 0.5 1.4 1.5 -1.2 -1.1 1.2
Number of full brothers 0.7 0.8 1.4 1.2 -0.3 -1.0
Worry too long after embarrassment 0.5 0.8 1.3 1.1 -1.2 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.7 0.9 -0.4 -0.8
Wheeze or whistling in the chest in last year 0.5 0.8 1.1 1.1 -0.8 0.8
Number of children fathered 0.4 0.5 0.9 -1.0 -0.3 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.5 -0.5 -1.2 1.2
Age at first live birth 2.2 3.8 5.9 -0.5 -2.3 2.4
Pulse wave peak to peak time 0.3 0.3 0.8 0.9 -0.3 0.1
Health satisfaction 1.0 1.3 1.4 1.2 -1.1 1.2
Shortness of breath walking on level ground 0.5 0.6 1.2 0.6 1.1 -0.4
Qualifications: College or University degree 0.5 1.6 2.5 -0.3 -1.6 1.5
Eye problems/disorders: None of the above 1.1 1.3 3.7 -0.4 -0.2 -1.9
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 0.8 0.6 0.0
Emphysema/chronic bronchitis 2.1 2.4 5.0 0.5 -2.2 1.4
Medication for pain relief, constipation, heartburn 0.3 0.5 1.0 -1.0 0.4 0.4
Neck or shoulder pain in last month 1.8 2.5 6.5 2.5 0.9 -0.3
Medication: Blood pressure 0.3 0.6 1.4 0.5 -0.1 1.2
Angina (self-reported) 0.5 0.7 1.6 0.1 0.7 -1.3
Migraine (self-reported) 2.5 3.1 7.2 -2.7 -1.0 1.1
Medication: Ibuprofen 1.1 1.4 2.6 0.1 -1.6 1.2
Medication: Allopurinol 2.0 2.6 3.8 -1.5 -1.3 -1.9
Medication: Omeprazole 0.5 0.7 1.2 1.1 0.1 -0.9
Medication: Seretide 50 evohaler 0.5 0.6 1.6 0.1 0.5 1.3
Mean time to correctly identify matches 1.2 2.2 3.8 -1.7 -0.3 -1.9
Heart disease (mother) 0.1 0.2 0.4 0.6 -0.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.2 -1.1 -1.1 0.7
Whole body fat mass 0.7 2.7 5.6 2.4 0.3 -1.6
Leg fat mass (right) 0.9 3.5 7.0 2.7 0.5 -1.8
Arm predicted mass (right) 0.1 0.6 1.2 -0.5 -0.5 -1.1
Pulse rate, automated reading 0.5 1.5 2.8 1.7 1.1 -0.7
Alcohol intake frequency. 0.6 1.3 3.0 1.7 -0.9 0.3
Comparative height size at age 10 0.8 4.2 12.5 -3.5 0.1 -0.2
Number of full sisters 1.6 2.0 2.3 1.2 -1.5 1.5
Suffer from ‘nerves’ 0.7 1.1 1.5 1.2 1.1 -0.7
Overall health rating 2.1 4.5 13.2 3.6 -0.5 -0.2
Chest pain or discomfort 1.5 2.2 5.8 2.4 -0.1 -0.8
Had major operations 0.5 0.6 1.0 1.0 0.0 0.9
Age at last live birth 0.7 1.0 2.4 -0.3 -1.6 0.7
Family relationship satisfaction 1.0 1.2 3.1 1.8 0.0 0.6
Leg pain on walking 0.9 1.1 1.4 1.2 1.1 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.6 1.6 0.1 0.0
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.8 -0.8 0.4 -0.9
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 0.8 0.8 0.6 0.9
Medication: Aspirin 0.2 0.2 0.5 -0.3 0.2 -0.7
Supplements: Vitamin C 0.4 0.5 1.2 0.4 -1.1 0.3
Knee pain experienced in last month 0.2 0.3 0.7 0.8 0.3 0.1
Hypertension (Self-reported) 0.4 1.1 2.2 -0.7 1.5 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.6 0.6 0.6 -0.7
Illnesses of father: Heart disease 0.2 0.3 0.4 0.6 0.6 -0.1
Illnesses of siblings: Diabetes 0.3 0.4 1.0 -0.2 0.3 -1.0
Smoking status: Previous 0.5 0.7 1.7 -0.6 -1.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 2.6 -1.3 -1.6 0.5
Whole body fat-free mass 0.2 1.3 3.0 -1.7 -0.8 -0.3
Leg fat-free mass (right) 0.2 1.1 2.3 -1.5 -0.7 -0.7
Arm fat percentage (left) 0.9 3.7 8.6 2.9 0.5 -1.4
Average weekly red wine intake 0.0 0.0 0.1 -0.0 -0.4 0.0
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 -0.2 0.3 1.0
Mood swings 0.6 1.0 2.4 1.6 -0.2 -0.8
Loneliness, isolation 0.3 0.4 0.6 -0.7 0.3 -0.8
Long-standing illness, disability or infirmity 0.6 0.9 1.4 1.2 0.3 -1.2
Ever had bowel cancer screening 0.6 0.7 1.2 0.3 0.9 -1.1
Diabetes diagnosed by doctor 0.1 0.1 0.3 0.5 0.2 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.5 -0.1 -1.2 -0.4
Friendships satisfaction 1.4 1.8 5.1 2.3 0.4 0.1
Qualifications: nursing, teaching 1.5 2.3 3.3 -1.3 1.4 -1.8
Commuting to job workplace: Walk 0.1 0.1 0.1 0.3 0.2 -0.1
Eye problems/disorders: Cataract 0.9 1.0 1.6 1.2 1.1 0.7
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.8 -0.7 -0.9 -0.1
Medication for cholesterol 1.2 1.8 3.6 0.4 -1.9 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.6 0.5 0.3 -1.3
Back pain experienced in last month 0.6 0.9 1.3 0.9 0.7 -1.2
Mineral and other dietary supplements 0.3 0.4 0.7 -0.4 0.8 -0.7
Breast cancer (self-reported) 0.8 1.0 1.9 0.7 0.7 -1.4
Asthma (self-reported) 1.8 3.5 5.8 -0.9 -2.4 2.0
Osteoporosis (self-reported) 0.6 0.8 1.4 -0.2 1.0 -1.2
Osteoarthritis (self-reported) 0.8 1.1 2.1 0.7 -0.8 1.5
Medication: Aspirin 0.2 0.2 0.5 -0.7 -0.4 -0.2
Medication: Gliclazide 0.4 0.4 1.1 -0.4 0.3 1.0
Illnesses of father: None of the above (group 1) 1.8 2.2 3.6 -0.2 -1.9 1.7
Smoking status: Current 0.8 1.2 2.8 -0.5 -1.7 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.4 -0.2 0.3 0.6
Whole body water mass 0.2 1.1 2.6 -1.6 -0.8 -0.4
Leg predicted mass (right) 0.2 1.1 2.3 -1.5 -0.8 -0.7
Arm fat mass (left) 0.6 2.4 4.2 2.1 0.4 -1.7
Number of self-reported non-cancer illnesses 0.3 0.4 1.3 0.2 0.1 -1.1
Average weekly champagne plus white wine intake 0.1 0.2 0.4 -0.2 -0.6 0.3
Miserableness 0.2 0.4 0.9 0.4 0.4 -1.0
Guilty feelings 0.8 1.2 2.8 0.2 -1.7 0.8
Wears glasses or contact lenses 0.8 0.9 1.1 -0.8 -1.0 1.0
Ever taken oral contraceptive pill 0.7 0.8 1.8 -0.8 -1.3 0.3
Hearing aid user 0.6 0.7 1.3 1.1 0.8 0.2
Mother’s age at death 1.5 1.9 3.6 -1.2 0.8 -1.9
Financial situation satisfaction 0.5 0.6 1.6 0.3 -0.3 1.3
Tinnitus: Yes, now most or all of the time 0.5 0.6 0.9 0.9 -0.6 0.7
Commuting to job workplace: Public transport 1.6 2.0 4.7 -0.0 -1.1 2.2
Eye problems/disorders: Glaucoma 1.0 1.2 2.1 -1.0 -1.4 0.8
Medication: Blood pressure 1.7 3.2 6.1 0.1 2.5 -1.9
Pain type(s) experienced in last month: Hip pain 1.6 2.0 5.5 2.3 0.5 -0.6
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.1 0.3 -0.0 0.3
High cholesterol (Self-reported) 1.2 2.1 3.4 0.4 1.9 -1.6
Medication: Bendroflumethiazide 0.1 0.2 0.5 0.1 -0.2 0.7
Medication: Paracetamol 1.1 1.7 2.8 1.2 -1.7 0.9
Medication: Lisinopril 0.2 0.3 0.8 0.9 0.1 0.4
Medication: Atorvastatin 0.8 1.0 2.0 0.1 0.9 -1.4
Illnesses of father: High blood pressure 0.4 0.4 0.8 -0.6 -0.9 -0.4
Alcohol drinker status: Never 0.8 0.9 1.7 -1.0 1.3 -0.1
Ever smoked 2.1 3.7 6.7 -2.1 -2.6 0.4
Basal metabolic rate 0.1 0.7 1.2 -1.1 -0.8 -0.6
Leg fat percentage (left) 2.2 8.1 19.4 4.4 0.8 -2.0
Arm fat-free mass (left) 0.1 0.6 1.0 -0.8 -0.4 -1.0
Number of operations (self-reported) 0.2 0.2 0.4 0.6 0.1 -0.6
Average weekly beer plus cider intake 0.2 0.2 0.7 0.8 0.0 -0.2
Irritability 0.2 0.4 1.0 0.3 -0.0 -1.0
Risk taking 0.9 1.3 3.0 0.4 -1.7 0.9
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 -0.3 -0.3 0.4
Fractured/broken bones in last 5 years 1.0 1.3 2.7 1.6 -0.3 -1.1
Age started oral contraceptive pill 3.8 4.8 10.4 1.5 3.2 -1.3
Diastolic blood pressure, automated reading 0.5 1.5 2.9 -0.2 1.2 -1.7
Ever depressed for a whole week 1.1 1.3 2.3 -0.8 1.5 1.1
Unable to work because of sickness or disability 0.3 0.4 0.6 0.7 -0.7 -0.4
Commuting to job workplace: Cycle 1.5 1.8 3.2 0.2 -1.8 1.5
Myopia 4.3 6.2 8.1 -1.7 -2.9 2.7
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.1 0.3 -1.0 0.5
Cholesterol lowering medication 2.5 3.7 6.8 1.0 2.6 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.4 0.9 -0.2 -1.2
Pain experienced in last month 0.3 0.4 1.1 -0.2 1.1 -0.3
Supplements: Calcium 0.5 0.6 1.5 0.5 -1.2 0.2
Basal cell carcinoma (self-reported) 1.0 1.1 2.2 -1.5 -1.0 -0.5
Heart attack/myocardial infarction (self-reported) 0.9 1.1 2.7 1.6 0.0 0.8
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.6 -0.0 -0.8 -0.1
Heart disease (siblings) 0.2 0.2 0.4 -0.4 0.0 -0.6
Alcohol drinker status: Previous 0.3 0.3 0.8 -0.9 -0.4 -0.1
Pack years of smoking 1.4 2.1 4.2 2.1 0.9 -1.1
Impedance of whole body 0.1 0.5 1.3 -0.4 -0.1 1.1
Leg fat mass (left) 1.1 4.2 8.4 2.9 0.5 -2.0
Arm predicted mass (left) 0.1 0.6 0.9 -0.8 -0.5 -1.0