Hub : Genes

ABHD17AP6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.1520	0.0630	6.7e-03	-0.008	NA	-0.007	NA	-0.007	8.1e-01	NA	7.4e-01	NA	6.9e-01
2	GTEx	Nerve Tibial	0.0794	0.0365	3.6e-03	0.015	NA	0.015	NA	0.012	2.8e-02	NA	2.8e-02	NA	4.2e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.1474	0.0364	9.5e-10	0.132	0.092	0.129	0.119	0.128	1.2e-16	6.5e-12	3.2e-16	4.8e-15	3.5e-16

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.0	0.0	0.0	-0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.2	0.6	1.6	-0.4	0.1	-1.3
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	-0.0	0.6	-0.7
Depression (Nagel 2018)	0.3	0.4	0.6	-0.8	-0.7	-0.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	-1.5	-0.6	-0.4
Neuroticism (Nagel 2018)	0.1	0.2	0.3	-0.0	0.5	-0.5
Schizophrenia (2018)	0.5	1.1	2.9	-0.5	0.3	-1.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	1.0	0.6	0.0
Worry (Nagel 2018)	0.5	1.0	1.5	0.5	1.2	-1.1
Alzheimer’s Disease (in mother)	2.2	2.6	3.4	1.1	1.9	-1.8
Alzheimer’s Disease (in father)	1.1	1.2	2.3	-1.5	1.0	-0.6
Alzheimer’s Disease (including proxy)	2.4	3.4	6.3	-0.3	2.5	-2.0
Crohns Disease (2017)	0.1	0.3	0.3	0.6	0.4	-0.6
Irritable Bowel Disease (IBD)	0.5	1.3	1.8	0.8	1.1	-1.4
Ulcerative Colitis (UC)	0.5	1.0	1.5	1.0	1.2	-0.7
Major Depression (MDD)	1.6	2.0	3.3	0.8	-1.8	1.4
Reaction Time	0.9	1.7	2.4	-1.6	-0.6	-1.5
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.4	-1.6	-0.9	-0.5
Breast Cancer	0.1	0.2	0.3	-0.2	-0.4	0.6
Ovarian Cancer	2.6	3.5	4.5	1.5	-2.1	1.9
Prostate Cancer	0.3	0.4	0.6	0.7	-0.8	0.3
Age at First Birth	0.5	0.7	1.7	-1.3	-0.2	0.6
Bipolar Disorder (2011)	0.3	0.3	0.5	0.6	0.0	-0.7
Body Mass Index (BMI) (2010)	1.0	1.4	2.4	1.0	1.6	-1.0
Coronary Artery Disease (CAD)	0.3	0.4	0.9	0.9	-0.5	0.1
Crohns Disease (2012)	0.0	0.1	0.1	0.1	-0.1	-0.4
Mean Putamen Volume	0.6	0.7	1.7	0.5	0.5	-1.3
Fasting Glucose	1.9	2.3	3.3	-1.8	-1.6	1.0
HbA1C	2.4	2.7	4.5	1.6	-2.1	1.0
HDL Cholesterol	1.0	1.7	2.8	-1.7	-0.9	1.2
LDL Cholesterol	0.9	1.4	2.3	1.1	1.5	-0.8
Lupus	0.2	0.3	0.6	-0.3	0.8	-0.4
Neuroticism (2016)	0.3	0.4	1.0	1.0	-0.3	-0.0
Primary Biliary Cirrhosis	1.0	1.4	2.6	1.6	1.0	-0.8
Rheumatoid Arthritis	1.8	2.5	5.4	2.3	1.0	-1.0
Schizophrenia (2014)	0.6	1.3	2.7	-1.1	-0.1	-1.6
Triglycerides	0.1	0.2	0.4	0.3	-0.3	-0.6
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.1	0.6	2.0	-1.7
Ulcerative Colitis	0.7	1.1	1.8	0.3	1.1	-1.3
Blood Eosinophil Count	0.0	0.1	0.2	-0.5	-0.4	0.0
Blood Platelet Count	0.4	4.8	8.1	0.6	2.4	-2.8
Blood Red Count	0.3	2.4	7.1	-0.5	-2.7	0.0
Blood White Count	0.2	1.4	2.4	-1.5	-0.0	-1.4
Heel T-Score	0.4	3.3	4.8	-1.3	2.2	-1.8
BMI	1.0	5.7	15.1	3.9	0.5	-1.3
Height	0.6	11.9	31.5	-5.6	-1.2	1.6
Waist Hip Ratio (WHR)	0.6	2.6	3.6	1.7	-1.1	1.9
Systolic Blood Pressure	0.4	1.8	4.0	-2.0	1.1	-0.5
Smoking Status	0.7	1.7	4.3	-0.8	-2.1	0.6
Allergy or Eczema	0.1	0.2	0.3	-0.3	-0.3	0.5
Cardiovascular Disease	0.4	1.3	2.6	-1.6	0.8	-0.9
Hypothyroidism (self reported)	0.4	0.9	2.2	0.7	-0.3	-1.5
Respiratory disease	0.7	1.6	2.7	-0.6	-1.6	1.4
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.4	0.1	-0.1
Lung FEV1/FVC ratio	0.2	0.8	1.7	0.4	1.3	-0.8
Lung FVC	0.2	1.2	1.8	1.3	-1.3	-0.3
Neuroticism	0.0	0.1	0.2	0.4	-0.1	-0.1
Chronotype (morning person)	0.1	0.1	0.3	0.2	0.1	-0.5
Hair Pigment	0.0	1.4	2.5	0.5	1.6	-1.2
Tanning	0.1	0.9	1.0	1.0	-0.9	1.0
Hand grip strength (left)	0.6	1.7	3.1	-1.8	-0.2	1.4
Number of treatments/medications taken	0.4	0.7	1.4	0.2	0.9	-1.2
Average weekly spirits intake	0.4	0.4	1.1	1.0	-0.2	0.5
Sensitivity / hurt feelings	0.3	0.5	1.1	1.0	-0.3	0.4
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.6	-0.8	-1.9	0.0
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.1	-0.4	0.3
Relative age of first facial hair	0.0	0.1	0.1	0.1	-0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.1	0.0	0.1	-1.8
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.7	-0.6	0.5	-1.3
Ever had hysterectomy (womb removed)	3.2	3.6	3.9	1.8	1.9	-2.0
Systolic blood pressure, automated reading	1.0	2.9	5.8	-0.5	2.4	-1.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.9	0.2	1.0	0.8
Angina	1.0	1.3	2.9	0.3	0.9	-1.7
Medication for hormone replacement therapy	1.1	1.2	2.0	-0.8	-1.4	1.0
Vitamin and mineral supplements	0.3	0.5	1.1	-1.0	0.4	-0.4
Supplements: Zinc	2.1	2.3	4.8	-0.4	-1.4	2.2
Medication: Co-codamol	0.7	0.8	1.5	1.2	0.6	-0.7
Medication: Metformin	0.2	0.3	0.5	0.6	0.7	0.1
Diabetes (father)	1.0	1.2	3.4	0.1	0.5	-1.8
Diabetes (mother)	0.4	0.5	0.9	0.6	0.9	-0.5
Severe depression (siblings)	0.8	0.9	2.0	-0.5	-1.4	0.7
Pack years adult smoking proportion	0.8	1.2	2.8	1.7	0.2	-0.8
Impedance of leg (right)	0.1	0.5	1.0	0.7	-0.5	1.0
Leg fat-free mass (left)	0.2	1.0	2.1	-1.5	-0.8	-0.5
Trunk fat percentage	1.0	4.0	8.2	2.9	0.6	-1.8
Hand grip strength (right)	0.2	0.6	1.9	-0.0	-0.1	1.4
Townsend deprivation index at recruitment	1.6	2.2	5.7	2.4	-0.4	0.8
Current tobacco smoking	0.9	1.5	3.5	-0.5	-1.9	0.8
Average weekly fortified wine intake	0.2	0.3	0.8	-0.9	0.2	0.1
Maternal smoking around birth	0.3	0.5	0.8	-0.9	-0.7	0.4
Fed-up feelings	0.3	0.6	1.4	-0.3	-1.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.4	0.5	-1.2	0.2
Relative age voice broke	0.1	0.1	0.2	-0.5	0.4	0.0
Taking other prescription medications	0.6	1.0	2.7	0.4	0.1	-1.6
Age when periods started (menarche)	0.4	0.9	2.5	-1.6	0.0	0.3
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	3.6	1.0	1.9	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	-1.2	-0.3	-0.6
Tinnitus: Yes, but not now, but have in the past	3.6	3.8	6.3	2.5	1.9	-1.3
Qualifications: CSEs or equivalent	0.3	0.4	1.0	-0.4	-0.4	1.0
Serious illness, injury or assault to yourself	1.2	1.4	1.9	1.2	0.9	-1.4
High blood pressure	0.2	0.5	0.9	-0.6	1.0	-0.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.6	-0.4	-1.3	0.9
Multivitamins +/- minerals	0.8	1.0	2.7	1.7	-0.1	0.6
Stomach or abdominal pain in last month	0.6	0.8	1.4	0.7	0.7	-1.2
Supplements: Glucosamine	0.2	0.3	0.7	-0.1	-0.3	0.9
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.7	-0.4	-1.6	0.5
Medication: Atenolol	1.5	1.8	3.6	1.1	1.9	-0.8
Medication: Levothyroxine sodium	0.2	0.4	0.6	-0.4	-0.6	-0.8
Sitting height	0.8	5.8	16.4	-4.0	-0.5	-0.9
Chronic bronchitis/emphysema (father)	2.5	2.9	6.1	0.8	1.4	-2.5
High blood pressure (mother)	0.2	0.3	0.5	-0.3	0.6	-0.7
Body mass index (BMI)	1.2	5.1	10.8	3.3	0.6	-2.0
Impedance of leg (left)	0.1	0.5	1.3	1.1	-0.4	0.4
Leg predicted mass (left)	0.2	0.9	1.9	-1.4	-0.8	-0.4
Trunk fat mass	0.5	2.3	4.3	2.1	0.3	-1.6
Waist circumference	0.6	2.3	5.3	2.3	0.1	-1.3
Number of incorrect matches in round	1.6	2.6	5.1	-0.1	1.6	-2.3
Past tobacco smoking	1.2	2.2	5.0	1.3	2.2	-0.1
Alcohol usually taken with meals	0.1	0.1	0.2	-0.4	-0.5	-0.3
Nervous feelings	0.5	0.9	1.4	1.1	-0.3	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-0.1	-1.2	0.3
Hearing difficulty/problems with background noise	0.3	0.5	0.8	0.7	-0.9	0.2
Hair/balding pattern: Pattern 2	1.9	2.4	6.4	-0.9	-2.5	0.1
Had menopause	4.0	5.0	9.2	0.7	3.0	-2.3
Had other major operations	0.3	0.4	1.0	0.4	1.0	0.0
Forced vital capacity (FVC)	0.6	2.3	4.5	-2.1	-1.3	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.1	-0.8	-0.8	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.7	-1.3	-0.1	0.5
Qualifications: None of the above	0.8	1.6	3.0	0.3	1.7	-1.3
Financial difficulties in last 2 years	1.7	2.3	3.6	-0.2	-1.9	1.8
Mouth/teeth dental problems	0.2	0.3	0.7	-0.8	0.5	-0.1
Heart attack	1.0	1.3	3.2	1.8	-0.0	0.8
Allergy	1.2	2.9	6.0	0.5	2.5	-1.5
Pain all over the body in last month	1.3	1.3	3.2	-0.8	-1.8	0.4
Diabetes (self-reported)	0.2	0.3	0.4	0.6	0.6	-0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.1	0.0	1.8	-0.6
Medication: Ramipril	0.6	0.8	1.4	-0.3	1.0	-1.2
Medication: Simvastatin	1.4	2.1	3.6	1.0	1.9	-1.2
Fluid intelligence score	1.7	3.6	5.2	-1.6	-2.3	1.7
Illnesses of siblings	0.7	1.0	2.5	0.6	-0.2	1.6
Neuroticism score	0.2	0.5	0.8	0.9	-0.6	-0.6
Weight	0.2	0.8	2.0	0.6	-0.1	-1.4
Impedance of arm (right)	0.3	1.2	2.1	-1.1	0.3	1.5
Arm fat percentage (right)	0.9	3.6	8.5	2.9	0.7	-1.4
Trunk fat-free mass	0.3	1.8	4.5	-2.1	-1.0	-0.0
Hip circumference	0.3	1.2	1.8	1.4	-0.1	-1.3
Time employed in main current job	3.6	4.2	8.5	-0.5	2.9	-1.9
Alcohol intake versus 10 years previously	0.2	0.3	0.4	0.6	-0.3	-0.6
Father’s age at death	0.8	1.1	2.7	0.7	-0.3	1.6
Worrier / anxious feelings	2.4	4.5	6.4	2.5	2.1	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.6	-0.2	-0.5
Falls in the last year	1.0	1.4	2.1	1.4	-1.4	-0.3
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	-0.6	0.5	-0.4
Number of live births	0.7	1.0	1.5	0.7	-1.2	-1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.1	-1.4	-0.5	0.7
Pulse rate	1.1	1.9	2.3	1.5	1.5	-1.1
Happiness	2.6	3.2	5.7	1.3	-1.4	2.4
Noisy workplace	1.0	1.2	2.0	0.2	1.4	-1.3
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.7	-1.3	-0.9	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.7	0.5	0.1	-1.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	0.9	-0.2	0.5
Asthma	1.3	2.5	3.6	-1.1	-1.9	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.3	0.2	-1.1	1.1
Medication: Cholesterol lowering	0.2	0.3	0.6	0.2	0.7	-0.6
Depression (self-reported)	1.4	1.6	2.3	1.5	-0.9	1.3
Medication: Lansoprazole	1.7	2.0	2.8	1.4	1.7	-1.1
Prospective memory result	4.4	5.4	7.8	1.6	2.8	-2.4
Lung cancer (father)	0.3	0.4	1.1	-1.0	-0.2	0.3
Illnesses of mother	0.1	0.1	0.3	-0.0	-0.6	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.8	-1.7	-0.6	0.6
Pulse wave Arterial Stiffness index	0.5	0.6	1.4	-1.2	0.5	-0.2
Impedance of arm (left)	0.2	1.1	1.6	-1.3	0.1	1.3
Arm fat mass (right)	0.6	2.3	4.4	2.1	0.3	-1.6
Trunk predicted mass	0.3	1.6	4.0	-2.0	-0.9	-0.1
Standing height	1.1	11.4	30.9	-5.6	-1.5	1.0
Length of working week for main job	0.7	0.7	1.7	0.3	-1.3	0.7
Exposure to tobacco smoke at home	1.0	1.1	2.7	1.6	-0.8	-0.3
Breastfed as a baby	0.4	0.5	1.2	-1.1	-0.4	-0.5
Tense / ‘highly strung’	0.4	0.7	1.5	-0.6	-1.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.3	1.1	0.1	-0.1
Hair/balding pattern: Pattern 4	0.7	1.6	2.6	-1.1	1.6	-0.9
Birth weight of first child	0.0	0.1	0.1	-0.3	-0.3	0.0
Peak expiratory flow (PEF)	0.1	0.2	0.6	-0.8	-0.1	0.1
Pulse wave reflection index	1.3	1.6	4.9	-2.2	-0.2	-0.0
Ever highly irritable/argumentative for 2 days	2.3	2.8	6.0	-0.8	-2.4	1.3
Loud music exposure frequency	2.4	2.7	4.3	0.6	-2.1	1.8
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	6.7	-2.6	-1.0	0.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	0.4	-0.7	0.9
Blood clot in the leg (DVT)	0.2	0.3	0.8	0.1	-0.9	-0.2
Medication: Paracetamol	0.6	1.1	1.7	1.3	-1.2	0.4
Headache pain in last month	0.9	1.5	2.5	0.3	-1.6	1.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.1	0.2	-0.4	-0.3
Glaucoma (self-reported)	0.5	0.5	1.0	-1.0	-0.8	0.1
Gout (self-reported)	1.3	1.7	2.4	-1.6	-1.2	-1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.7	-0.4	-0.4	-1.6
Medication: Amlodipine	0.2	0.3	0.6	-0.4	-0.2	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.0	-1.0	-0.1	-0.1
Birth weight	1.1	2.4	5.4	0.1	2.3	-1.3
Chronic bronchitis/emphysema (mother)	1.6	1.8	3.7	0.2	-1.9	1.3
High blood pressure (siblings)	1.8	2.6	5.8	-0.6	1.3	-2.4
Forced vital capacity (FVC), Best measure	0.6	2.1	3.7	-1.9	-1.3	1.0
Body fat percentage	1.4	5.4	13.0	3.6	0.6	-1.7
Leg fat percentage (right)	1.8	6.7	16.2	4.0	0.8	-1.8
Arm fat-free mass (right)	0.2	0.9	1.3	-0.9	-0.7	-1.1
Exposure to tobacco smoke outside home	3.9	5.2	13.0	3.6	1.1	-1.2
Comparative body size at age 10	0.5	1.4	1.5	-1.2	-1.1	1.2
Number of full brothers	0.7	0.8	1.4	1.2	-0.3	-1.0
Worry too long after embarrassment	0.5	0.8	1.3	1.1	-1.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.7	0.9	-0.4	-0.8
Wheeze or whistling in the chest in last year	0.5	0.8	1.1	1.1	-0.8	0.8
Number of children fathered	0.4	0.5	0.9	-1.0	-0.3	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.5	-0.5	-1.2	1.2
Age at first live birth	2.2	3.8	5.9	-0.5	-2.3	2.4
Pulse wave peak to peak time	0.3	0.3	0.8	0.9	-0.3	0.1
Health satisfaction	1.0	1.3	1.4	1.2	-1.1	1.2
Shortness of breath walking on level ground	0.5	0.6	1.2	0.6	1.1	-0.4
Qualifications: College or University degree	0.5	1.6	2.5	-0.3	-1.6	1.5
Eye problems/disorders: None of the above	1.1	1.3	3.7	-0.4	-0.2	-1.9
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	0.8	0.6	0.0
Emphysema/chronic bronchitis	2.1	2.4	5.0	0.5	-2.2	1.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-1.0	0.4	0.4
Neck or shoulder pain in last month	1.8	2.5	6.5	2.5	0.9	-0.3
Medication: Blood pressure	0.3	0.6	1.4	0.5	-0.1	1.2
Angina (self-reported)	0.5	0.7	1.6	0.1	0.7	-1.3
Migraine (self-reported)	2.5	3.1	7.2	-2.7	-1.0	1.1
Medication: Ibuprofen	1.1	1.4	2.6	0.1	-1.6	1.2
Medication: Allopurinol	2.0	2.6	3.8	-1.5	-1.3	-1.9
Medication: Omeprazole	0.5	0.7	1.2	1.1	0.1	-0.9
Medication: Seretide 50 evohaler	0.5	0.6	1.6	0.1	0.5	1.3
Mean time to correctly identify matches	1.2	2.2	3.8	-1.7	-0.3	-1.9
Heart disease (mother)	0.1	0.2	0.4	0.6	-0.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.2	-1.1	-1.1	0.7
Whole body fat mass	0.7	2.7	5.6	2.4	0.3	-1.6
Leg fat mass (right)	0.9	3.5	7.0	2.7	0.5	-1.8
Arm predicted mass (right)	0.1	0.6	1.2	-0.5	-0.5	-1.1
Pulse rate, automated reading	0.5	1.5	2.8	1.7	1.1	-0.7
Alcohol intake frequency.	0.6	1.3	3.0	1.7	-0.9	0.3
Comparative height size at age 10	0.8	4.2	12.5	-3.5	0.1	-0.2
Number of full sisters	1.6	2.0	2.3	1.2	-1.5	1.5
Suffer from ‘nerves’	0.7	1.1	1.5	1.2	1.1	-0.7
Overall health rating	2.1	4.5	13.2	3.6	-0.5	-0.2
Chest pain or discomfort	1.5	2.2	5.8	2.4	-0.1	-0.8
Had major operations	0.5	0.6	1.0	1.0	0.0	0.9
Age at last live birth	0.7	1.0	2.4	-0.3	-1.6	0.7
Family relationship satisfaction	1.0	1.2	3.1	1.8	0.0	0.6
Leg pain on walking	0.9	1.1	1.4	1.2	1.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.6	1.6	0.1	0.0
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.8	-0.8	0.4	-0.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	0.8	0.6	0.9
Medication: Aspirin	0.2	0.2	0.5	-0.3	0.2	-0.7
Supplements: Vitamin C	0.4	0.5	1.2	0.4	-1.1	0.3
Knee pain experienced in last month	0.2	0.3	0.7	0.8	0.3	0.1
Hypertension (Self-reported)	0.4	1.1	2.2	-0.7	1.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.6	0.6	0.6	-0.7
Illnesses of father: Heart disease	0.2	0.3	0.4	0.6	0.6	-0.1
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.2	0.3	-1.0
Smoking status: Previous	0.5	0.7	1.7	-0.6	-1.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.6	-1.3	-1.6	0.5
Whole body fat-free mass	0.2	1.3	3.0	-1.7	-0.8	-0.3
Leg fat-free mass (right)	0.2	1.1	2.3	-1.5	-0.7	-0.7
Arm fat percentage (left)	0.9	3.7	8.6	2.9	0.5	-1.4
Average weekly red wine intake	0.0	0.0	0.1	-0.0	-0.4	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-0.2	0.3	1.0
Mood swings	0.6	1.0	2.4	1.6	-0.2	-0.8
Loneliness, isolation	0.3	0.4	0.6	-0.7	0.3	-0.8
Long-standing illness, disability or infirmity	0.6	0.9	1.4	1.2	0.3	-1.2
Ever had bowel cancer screening	0.6	0.7	1.2	0.3	0.9	-1.1
Diabetes diagnosed by doctor	0.1	0.1	0.3	0.5	0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	-0.1	-1.2	-0.4
Friendships satisfaction	1.4	1.8	5.1	2.3	0.4	0.1
Qualifications: nursing, teaching	1.5	2.3	3.3	-1.3	1.4	-1.8
Commuting to job workplace: Walk	0.1	0.1	0.1	0.3	0.2	-0.1
Eye problems/disorders: Cataract	0.9	1.0	1.6	1.2	1.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	-0.7	-0.9	-0.1
Medication for cholesterol	1.2	1.8	3.6	0.4	-1.9	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.6	0.5	0.3	-1.3
Back pain experienced in last month	0.6	0.9	1.3	0.9	0.7	-1.2
Mineral and other dietary supplements	0.3	0.4	0.7	-0.4	0.8	-0.7
Breast cancer (self-reported)	0.8	1.0	1.9	0.7	0.7	-1.4
Asthma (self-reported)	1.8	3.5	5.8	-0.9	-2.4	2.0
Osteoporosis (self-reported)	0.6	0.8	1.4	-0.2	1.0	-1.2
Osteoarthritis (self-reported)	0.8	1.1	2.1	0.7	-0.8	1.5
Medication: Aspirin	0.2	0.2	0.5	-0.7	-0.4	-0.2
Medication: Gliclazide	0.4	0.4	1.1	-0.4	0.3	1.0
Illnesses of father: None of the above (group 1)	1.8	2.2	3.6	-0.2	-1.9	1.7
Smoking status: Current	0.8	1.2	2.8	-0.5	-1.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.2	0.3	0.6
Whole body water mass	0.2	1.1	2.6	-1.6	-0.8	-0.4
Leg predicted mass (right)	0.2	1.1	2.3	-1.5	-0.8	-0.7
Arm fat mass (left)	0.6	2.4	4.2	2.1	0.4	-1.7
Number of self-reported non-cancer illnesses	0.3	0.4	1.3	0.2	0.1	-1.1
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.2	-0.6	0.3
Miserableness	0.2	0.4	0.9	0.4	0.4	-1.0
Guilty feelings	0.8	1.2	2.8	0.2	-1.7	0.8
Wears glasses or contact lenses	0.8	0.9	1.1	-0.8	-1.0	1.0
Ever taken oral contraceptive pill	0.7	0.8	1.8	-0.8	-1.3	0.3
Hearing aid user	0.6	0.7	1.3	1.1	0.8	0.2
Mother’s age at death	1.5	1.9	3.6	-1.2	0.8	-1.9
Financial situation satisfaction	0.5	0.6	1.6	0.3	-0.3	1.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	0.9	-0.6	0.7
Commuting to job workplace: Public transport	1.6	2.0	4.7	-0.0	-1.1	2.2
Eye problems/disorders: Glaucoma	1.0	1.2	2.1	-1.0	-1.4	0.8
Medication: Blood pressure	1.7	3.2	6.1	0.1	2.5	-1.9
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.5	2.3	0.5	-0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.3	-0.0	0.3
High cholesterol (Self-reported)	1.2	2.1	3.4	0.4	1.9	-1.6
Medication: Bendroflumethiazide	0.1	0.2	0.5	0.1	-0.2	0.7
Medication: Paracetamol	1.1	1.7	2.8	1.2	-1.7	0.9
Medication: Lisinopril	0.2	0.3	0.8	0.9	0.1	0.4
Medication: Atorvastatin	0.8	1.0	2.0	0.1	0.9	-1.4
Illnesses of father: High blood pressure	0.4	0.4	0.8	-0.6	-0.9	-0.4
Alcohol drinker status: Never	0.8	0.9	1.7	-1.0	1.3	-0.1
Ever smoked	2.1	3.7	6.7	-2.1	-2.6	0.4
Basal metabolic rate	0.1	0.7	1.2	-1.1	-0.8	-0.6
Leg fat percentage (left)	2.2	8.1	19.4	4.4	0.8	-2.0
Arm fat-free mass (left)	0.1	0.6	1.0	-0.8	-0.4	-1.0
Number of operations (self-reported)	0.2	0.2	0.4	0.6	0.1	-0.6
Average weekly beer plus cider intake	0.2	0.2	0.7	0.8	0.0	-0.2
Irritability	0.2	0.4	1.0	0.3	-0.0	-1.0
Risk taking	0.9	1.3	3.0	0.4	-1.7	0.9
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.3	-0.3	0.4
Fractured/broken bones in last 5 years	1.0	1.3	2.7	1.6	-0.3	-1.1
Age started oral contraceptive pill	3.8	4.8	10.4	1.5	3.2	-1.3
Diastolic blood pressure, automated reading	0.5	1.5	2.9	-0.2	1.2	-1.7
Ever depressed for a whole week	1.1	1.3	2.3	-0.8	1.5	1.1
Unable to work because of sickness or disability	0.3	0.4	0.6	0.7	-0.7	-0.4
Commuting to job workplace: Cycle	1.5	1.8	3.2	0.2	-1.8	1.5
Myopia	4.3	6.2	8.1	-1.7	-2.9	2.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.1	0.3	-1.0	0.5
Cholesterol lowering medication	2.5	3.7	6.8	1.0	2.6	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.4	0.9	-0.2	-1.2
Pain experienced in last month	0.3	0.4	1.1	-0.2	1.1	-0.3
Supplements: Calcium	0.5	0.6	1.5	0.5	-1.2	0.2
Basal cell carcinoma (self-reported)	1.0	1.1	2.2	-1.5	-1.0	-0.5
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.7	1.6	0.0	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	-0.0	-0.8	-0.1
Heart disease (siblings)	0.2	0.2	0.4	-0.4	0.0	-0.6
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.9	-0.4	-0.1
Pack years of smoking	1.4	2.1	4.2	2.1	0.9	-1.1
Impedance of whole body	0.1	0.5	1.3	-0.4	-0.1	1.1
Leg fat mass (left)	1.1	4.2	8.4	2.9	0.5	-2.0
Arm predicted mass (left)	0.1	0.6	0.9	-0.8	-0.5	-1.0