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chr17:36,211,659-39,048,774

Best TWAS P=2.47e-50 · Best GWAS P=2.91e-56 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PSMB3	0.11	0.01	enet	8	0.03	2.7e-03	-10.69	-7.9	2.9e-15	0.03	0.01	0.95	FALSE
2	GTEx	Adipose Subcutaneous	PIP4K2B	0.15	0.07	lasso	5	0.07	2.2e-06	-14.71	-14.2	8.9e-46	0.07	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	MSL1	0.15	0.12	lasso	2	0.12	3.9e-10	12.24	-12.3	1.7e-34	0.29	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	PSMB3	0.14	0.01	enet	9	0.03	1.2e-02	-2.49	-6.8	1.2e-11	0.02	0.08	0.49	FALSE
5	GTEx	Adipose Visceral Omentum	RAPGEFL1	0.50	0.35	enet	18	0.36	1.3e-19	-4.25	-6.1	9.8e-10	0.23	1.00	0.00	TRUE
6	GTEx	Adrenal Gland	SNORD124	0.22	0.01	lasso	6	0.02	4.8e-02	-8.45	8.9	5.4e-19	-0.54	0.04	0.17	FALSE
7	GTEx	Artery Aorta	PSMB3	0.23	0.17	enet	26	0.22	2.1e-12	-14.71	-13.1	4.8e-39	0.05	0.00	1.00	TRUE
8	GTEx	Artery Aorta	PIP4K2B	0.31	0.03	enet	42	0.10	2.6e-06	-0.74	-8.0	1.9e-15	0.05	0.04	0.94	FALSE
9	GTEx	Artery Aorta	PGAP3	0.13	0.04	lasso	3	0.10	5.3e-06	-5.19	-5.5	3.2e-08	0.05	0.78	0.01	TRUE
10	GTEx	Artery Tibial	PSMB3	0.10	0.02	enet	12	0.03	1.2e-03	-14.71	-12.3	1.2e-34	0.06	0.00	1.00	TRUE
11	GTEx	Artery Tibial	PIP4K2B	0.37	0.16	enet	49	0.22	2.1e-17	-14.71	-12.3	6.3e-35	0.04	0.00	1.00	FALSE
12	GTEx	Artery Tibial	MSL1	0.19	0.14	lasso	2	0.15	4.9e-12	12.24	-12.4	4.3e-35	0.25	1.00	0.00	FALSE
13	GTEx	Brain Cortex	MED24	0.36	0.03	enet	27	0.09	2.2e-03	-5.62	6.6	3.1e-11	-0.10	0.08	0.07	TRUE
14	GTEx	Breast Mammary Tissue	RAPGEFL1	0.37	0.22	lasso	5	0.22	2.0e-11	-4.25	-5.6	2.7e-08	0.20	1.00	0.00	FALSE
15	GTEx	Breast Mammary Tissue	ORMDL3	0.17	0.04	enet	27	0.06	7.2e-04	-3.34	-6.5	8.3e-11	0.22	0.46	0.10	FALSE
16	GTEx	Breast Mammary Tissue	MSL1	0.20	0.06	lasso	6	0.07	2.2e-04	12.24	-10.8	2.2e-27	0.18	0.40	0.14	FALSE
17	GTEx	Breast Mammary Tissue (Female)	MSL1	0.09	0.00	enet	9	0.03	5.8e-02	12.24	-10.1	8.9e-24	0.08	0.03	0.08	TRUE
18	GTEx	Cells Transformed fibroblasts	STARD3	0.08	0.01	enet	18	0.01	3.3e-02	-5.22	-5.4	5.4e-08	0.03	0.32	0.06	TRUE
19	GTEx	Colon Transverse	MSL1	0.18	0.11	lasso	3	0.05	2.1e-03	12.24	-12.5	9.2e-36	0.28	0.23	0.04	TRUE
20	GTEx	Esophagus Mucosa	CWC25	0.11	0.07	enet	7	0.05	1.5e-04	-7.89	-8.9	5.3e-19	0.02	0.32	0.55	FALSE
21	GTEx	Esophagus Mucosa	LINC00672	0.13	0.00	enet	28	0.00	8.3e-01	2.85	7.2	5.9e-13	-0.08	0.05	0.16	FALSE
22	GTEx	Esophagus Muscularis	FBXL20	0.04	0.03	lasso	3	0.02	1.2e-02	-6.60	5.8	7.9e-09	-0.03	0.35	0.04	FALSE
23	GTEx	Esophagus Muscularis	MSL1	0.25	0.18	lasso	8	0.22	1.7e-13	12.07	-11.4	3.1e-30	0.22	1.00	0.00	FALSE
24	GTEx	Heart Left Ventricle	RAPGEFL1	0.38	0.26	lasso	6	0.24	8.1e-13	-4.65	-5.3	1.1e-07	0.16	1.00	0.00	FALSE
25	GTEx	Heart Left Ventricle	PGAP3	0.17	0.14	lasso	5	0.12	4.3e-07	-5.22	-5.2	2.4e-07	0.03	0.98	0.00	TRUE
26	GTEx	Lung	RAPGEFL1	0.43	0.08	enet	10	0.19	1.2e-14	-4.65	-5.5	3.5e-08	0.21	1.00	0.00	FALSE
27	GTEx	Nerve Tibial	MSL1	0.33	0.25	lasso	4	0.24	6.3e-17	12.24	-12.5	7.1e-36	0.27	1.00	0.00	FALSE
28	GTEx	Pituitary	CWC25	0.30	0.00	enet	18	0.07	7.4e-03	-9.36	-8.4	3.6e-17	0.02	0.08	0.25	FALSE
29	GTEx	Pituitary	MSL1	0.40	0.27	lasso	7	0.24	1.3e-06	9.93	-11.1	1.1e-28	0.25	0.20	0.22	TRUE
30	GTEx	Pituitary	RP5-906A24.2	0.34	0.00	lasso	4	0.04	3.0e-02	-1.35	-7.2	4.7e-13	0.16	0.05	0.08	TRUE
31	GTEx	Skin Not Sun Exposed Suprapubic	MSL1	0.18	0.15	lasso	4	0.15	2.1e-08	12.24	-12.0	6.0e-33	0.30	0.90	0.02	FALSE
32	GTEx	Skin Sun Exposed Lower leg	MSL1	0.08	0.04	lasso	2	0.05	8.1e-05	9.05	-11.4	4.8e-30	0.19	0.52	0.03	FALSE
33	GTEx	Testis	PSMB3	0.30	0.24	lasso	4	0.21	8.9e-10	-14.71	-14.8	1.7e-49	0.07	0.00	1.00	FALSE
34	GTEx	Testis	PIP4K2B	0.22	0.00	enet	19	0.03	1.9e-02	-9.36	8.8	9.3e-19	0.02	0.04	0.39	FALSE
35	GTEx	Testis	MSL1	0.23	0.05	enet	9	0.15	2.9e-07	12.24	-8.3	8.3e-17	0.28	0.33	0.09	TRUE
36	GTEx	Thyroid	CWC25	0.12	0.10	lasso	2	0.08	1.2e-06	-6.38	-6.3	3.1e-10	0.02	0.82	0.13	FALSE
37	GTEx	Thyroid	RAPGEFL1	0.57	0.41	lasso	10	0.41	1.0e-33	-4.65	-5.2	1.8e-07	0.17	1.00	0.00	TRUE
38	GTEx	Thyroid	THRA	0.06	0.01	lasso	4	0.00	3.5e-01	-6.28	5.6	2.2e-08	-0.05	0.09	0.03	FALSE
39	METSIM	Adipose	CWC25	0.05	0.02	enet	40	0.03	1.3e-05	-5.41	5.8	7.9e-09	-0.10	0.48	0.06	TRUE
40	METSIM	Adipose	LINC00672	0.07	0.01	bslmm	351	0.01	9.1e-03	4.47	9.8	1.3e-22	-0.13	0.04	0.54	FALSE
41	METSIM	Adipose	MSL1	0.12	0.06	lasso	10	0.06	1.8e-09	12.24	-12.2	2.0e-34	0.29	0.99	0.00	FALSE
42	METSIM	Adipose	PIP4K2B	0.06	0.01	blup	360	0.02	7.0e-04	-5.90	-8.9	4.5e-19	0.06	0.01	0.98	FALSE
43	METSIM	Adipose	PSMB3	0.04	0.02	lasso	5	0.01	2.3e-03	-12.49	-11.0	3.0e-28	0.01	0.14	0.31	FALSE
44	NTR	Blood	GSDMA	0.11	0.05	enet	34	0.04	2.8e-14	2.62	5.2	1.8e-07	-0.18	1.00	0.00	TRUE
45	NTR	Blood	PIP4K2B	0.02	0.01	lasso	3	0.01	6.4e-04	-14.71	14.0	1.4e-44	-0.09	0.00	1.00	FALSE
46	YFS	Blood	PSMB3	0.14	0.11	enet	31	0.16	7.2e-49	-14.50	-11.4	3.8e-30	0.05	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PIP4K2B	0.07	0.01	blup	50	0.04	2.5e-04	-7.21	-6.8	1.3e-11	0.04	0.03	0.18	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PSMB3	0.04	0.00	blup	37	0.02	6.7e-03	-5.90	-10.0	1.7e-23	0.05	0.01	0.63	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PIP4K2B	0.04	0.01	blup	56	0.03	6.3e-04	-14.50	-12.0	3.4e-33	0.11	0.00	0.92	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STARD3	0.03	0.04	enet	5	0.02	8.2e-04	-5.92	-5.9	4.4e-09	0.04	0.54	0.30	TRUE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PIP4K2B	0.07	0.01	enet	12	0.02	4.3e-03	-9.36	-10.3	6.1e-25	0.00	0.03	0.29	TRUE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMB3	0.14	0.05	blup	42	0.05	8.9e-07	-14.50	-12.7	4.7e-37	0.06	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMB3	0.12	0.02	enet	14	0.05	1.3e-03	-12.06	-11.1	1.3e-28	0.07	0.00	0.74	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RAPGEFL1	0.13	0.02	enet	9	0.06	4.3e-04	9.90	-10.8	2.9e-27	0.38	0.01	0.73	TRUE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	IGFBP4	0.04	0.02	blup	38	0.03	5.9e-04	-15.80	-10.5	9.8e-26	0.80	0.00	0.97	TRUE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAPGEFL1	0.12	0.04	lasso	4	0.06	1.3e-07	-4.61	-5.3	1.1e-07	0.14	0.96	0.00	FALSE
57	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PCGF2	0.11	0.00	blup	37	0.03	1.0e-02	-11.97	5.9	2.9e-09	-0.01	0.01	0.05	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	FBXL20	0.04	0.01	blup	72	0.01	7.6e-03	-6.59	6.2	4.4e-10	-0.05	0.01	0.56	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RPL23	0.10	0.00	enet	19	0.04	2.0e-03	-8.40	-7.6	2.7e-14	0.02	0.01	0.62	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	PIP4K2B	0.05	0.04	blup	56	0.05	5.3e-06	-12.06	-14.0	2.4e-44	0.10	0.00	0.99	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMB3	0.11	0.07	blup	42	0.07	9.4e-08	-14.71	-10.0	9.3e-24	0.06	0.00	1.00	TRUE
62	The Cancer Genome Atlas	Rectum Adenocarcinoma	CDK12	0.17	0.00	blup	44	0.05	2.5e-02	-4.60	-5.3	1.5e-07	0.01	0.01	0.25	FALSE
63	The Cancer Genome Atlas	Soft Tissue Sarcoma	PCGF2	0.18	0.05	blup	36	0.11	7.3e-07	-2.50	7.6	2.1e-14	-0.10	0.08	0.84	TRUE
64	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PSMB3	0.12	0.09	lasso	3	0.06	3.0e-03	-14.50	-14.9	2.5e-50	0.08	0.00	0.93	TRUE
65	The Cancer Genome Atlas	Thyroid Carcinoma	PSMB3	0.05	0.06	lasso	1	0.05	2.4e-05	-14.71	-14.7	5.7e-49	0.07	0.00	1.00	FALSE