TWAS hub - THRA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1160	0.0510	6.1e-03	0.003	NA	0.016	NA	0.012	1.8e-01	NA	1.6e-02	NA	3.5e-02
2	GTEx	Thyroid	0.0560	0.0310	9.5e-03	0.008	NA	-0.003	NA	0.000	7.5e-02	NA	7.0e-01	NA	3.5e-01
3	YFS	Blood	0.0584	0.0165	7.3e-10	0.056	0.027	0.044	0.048	0.056	1.2e-17	2.4e-09	2.8e-14	2.5e-15	1.1e-17

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood White Count	128.9	955.0	2043.0	27.2	45.2	9.1
Respiratory disease	21.4	47.7	70.4	7.8	8.4	3.5
Asthma (self-reported)	20.0	39.8	53.4	7.3	7.2	3.7
Asthma	19.5	38.5	53.1	7.3	7.0	3.7
Allergy	16.5	38.0	55.5	-7.5	-7.4	-1.9
Hayfever, allergic rhinitis or eczema	12.2	26.5	46.9	6.8	5.6	1.2
Allergy or Eczema	11.4	30.1	45.8	6.8	6.5	1.6
Wheeze or whistling in the chest in last year	10.2	18.2	27.2	4.8	5.2	2.1
Chest pain or discomfort	8.3	11.9	21.1	2.4	4.6	3.0
Medication: Ventolin 100micrograms inhaler	8.1	10.4	17.6	4.2	2.9	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	8.0	12.3	12.9	3.5	3.6	3.4
Taking other prescription medications	7.5	11.5	16.0	3.7	4.0	2.2
Ever depressed for a whole week	7.5	9.3	13.0	3.6	3.2	2.2
Emphysema/chronic bronchitis	7.4	8.3	13.8	2.9	3.7	1.7
Miserableness	7.2	12.4	15.4	2.7	3.9	3.8
Seen a psychiatrist for nerves, anxiety, tension or depression	7.0	9.1	11.8	2.6	3.4	3.0
Exposure to tobacco smoke outside home	6.9	9.2	14.3	3.8	3.4	1.2
Loneliness, isolation	6.7	9.2	11.1	3.1	3.3	2.6
Depressed Affect (Nagel 2018)	6.3	13.3	23.7	2.7	4.9	3.0
Number of self-reported non-cancer illnesses	6.3	10.9	11.8	3.1	3.3	3.4
Frequency of depressed mood in last 2 weeks	6.0	8.4	17.6	2.4	4.2	1.3
Family relationship satisfaction	6.0	7.3	13.7	3.7	1.9	2.2
Happiness	5.6	6.8	9.4	3.1	2.0	2.6
Guilty feelings	5.5	8.3	16.5	2.5	4.1	1.4
Neuroticism (Nagel 2018)	5.4	12.6	27.2	1.2	5.2	3.0
Ulcerative Colitis (UC)	5.3	10.0	23.5	-2.4	-4.8	0.9
HDL Cholesterol	5.2	8.7	13.9	-3.7	-3.4	-0.7
Alcohol usually taken with meals	5.2	8.5	11.3	-3.4	-2.4	-2.9
Average weekly spirits intake	5.0	6.2	14.1	3.8	1.7	1.3
Time employed in main current job	4.9	5.6	9.0	-3.0	-2.2	-1.7
Smoking status: Current	4.7	7.4	14.7	3.8	1.7	2.1
Blood Eosinophil Count	4.6	35.4	44.6	6.7	6.3	4.7
Current tobacco smoking	4.6	7.6	14.5	3.8	1.8	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.6	5.4	8.3	2.9	1.0	2.6
Financial situation satisfaction	4.4	5.4	8.7	2.0	1.9	3.0
Depression (Nagel 2018)	4.3	6.4	14.3	1.9	3.8	1.1
Schizophrenia vs Biploar Disorder	4.2	5.6	12.2	-2.1	-3.5	-0.5
Number of treatments/medications taken	4.2	7.6	9.0	2.9	3.0	2.3
Chronic bronchitis/emphysema (mother)	4.2	4.9	11.5	1.0	3.4	1.5
Neuroticism score	4.0	8.3	19.6	0.8	4.4	2.1
Irritable Bowel Disease (IBD)	3.9	9.3	20.2	-2.7	-4.5	0.5
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.4	8.7	1.7	2.8	3.0
Ulcerative Colitis	3.8	5.5	12.4	-1.6	-3.5	1.2
Townsend deprivation index at recruitment	3.7	5.1	9.0	2.4	3.0	0.8
Neuroticism	3.6	8.6	21.6	0.3	4.7	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.6	7.6	13.3	-3.7	-2.8	-1.3
Illnesses of father: Heart disease	3.5	4.9	9.1	1.0	3.0	2.2
Average weekly champagne plus white wine intake	3.5	4.8	10.0	-1.0	-1.8	-3.2
Fed-up feelings	3.3	5.9	11.1	1.2	3.3	2.3
Suffer from ‘nerves’	3.3	5.2	8.2	0.2	2.9	2.7
Prostate Cancer	3.1	4.4	9.9	-1.3	-3.1	-1.3
Body Mass Index (BMI) (2010)	3.1	4.3	6.2	-2.5	-2.1	-1.5
Vitamin and mineral supplements	3.1	4.2	4.9	-2.2	-1.8	-2.1
Smoking Status	3.0	7.2	13.1	3.6	2.5	1.5
Worry too long after embarrassment	3.0	5.1	12.0	0.9	3.5	1.5
Medication: Seretide 50 evohaler	3.0	3.5	5.2	1.7	2.3	1.5
Supplements: Vitamin C	3.0	3.6	6.4	2.5	0.8	1.9
Basal cell carcinoma (self-reported)	3.0	3.5	7.8	1.5	2.8	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	7.0	1.3	1.3	2.7
Bipolar Disorder (2018)	2.8	4.4	10.9	1.3	3.3	0.7
Waist Hip Ratio (WHR)	2.8	12.4	15.6	4.0	3.9	2.6
Illnesses of mother	2.8	3.5	6.2	0.5	-2.0	-2.5
Gout (self-reported)	2.8	3.8	7.7	-1.6	-1.1	-2.8
Serious illness, injury or assault to yourself	2.7	3.2	6.5	1.4	2.5	1.2
Impedance of arm (right)	2.7	12.6	17.3	4.1	4.2	2.0
Lung FEV1/FVC ratio	2.6	13.1	28.0	-5.3	-3.1	-1.4
Chronic bronchitis/emphysema (father)	2.6	3.1	4.8	2.2	2.0	0.4
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	4.8	1.7	2.2	1.4
Headache pain in last month	2.6	4.5	7.2	1.1	2.7	2.3
Pack years of smoking	2.6	3.8	8.5	2.9	0.6	1.6
Worry (Nagel 2018)	2.5	5.3	11.4	-0.7	3.4	2.0
Medication: Co-codamol	2.5	2.9	7.0	1.2	-0.5	2.7
Severe depression (siblings)	2.5	2.8	3.3	1.4	1.8	1.7
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	10.2	0.9	3.2	0.8
Father’s age at death	2.5	3.3	5.7	-2.0	-2.4	-0.6
Migraine (self-reported)	2.5	3.1	5.0	1.2	2.2	1.6
Handedness (chirality/laterality): Left-handed	2.5	3.0	4.7	2.2	-1.1	1.7
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	3.9	1.8	2.0	1.5
Impedance of arm (left)	2.4	11.1	13.2	3.6	3.6	2.7
Birth weight of first child	2.4	4.3	9.6	1.8	3.1	0.3
Primary Biliary Cirrhosis	2.3	3.3	5.1	-0.4	-2.3	2.1
Worrier / anxious feelings	2.3	4.3	9.6	-0.0	3.1	1.8
Pack years adult smoking proportion	2.2	3.4	7.7	2.8	0.9	1.3
Multivitamins +/- minerals	2.2	2.8	3.8	2.0	1.5	1.5
Depression (self-reported)	2.2	2.6	5.4	1.5	2.3	0.2
Nervous feelings	2.1	3.9	7.8	-0.0	2.8	2.0
Qualifications: None of the above	2.1	4.5	8.8	3.0	1.6	1.5
Neck or shoulder pain in last month	2.1	3.0	4.4	1.1	2.1	1.8
Had major operations	2.1	2.4	4.5	1.1	1.3	2.1
Pain experienced in last month	2.1	3.4	6.6	-1.1	-2.6	-1.6
Hair/balding pattern: Pattern 2	2.0	2.5	3.8	1.9	1.9	0.3
Hayfever/allergic rhinitis (self-reported)	2.0	2.7	6.1	2.5	1.4	-0.1
Tense / ‘highly strung’	2.0	3.4	8.7	-0.6	3.0	1.0
Medication: Allopurinol	2.0	2.7	6.7	-1.1	0.4	-2.6
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	7.5	-2.7	-0.9	1.1
Ever smoked	2.0	3.5	5.3	2.3	2.2	0.5
Reaction Time	1.9	3.6	9.2	0.7	3.0	1.1
Chronotype (morning person)	1.9	4.3	8.1	-2.0	-2.8	-0.8
Medication: Simvastatin	1.9	2.7	5.1	2.2	0.7	1.6
Heart disease (mother)	1.9	2.3	4.5	1.5	2.1	0.5
Diabetes diagnosed by doctor	1.9	3.2	5.2	2.0	0.3	2.3
Diabetes (self-reported)	1.8	2.8	5.2	2.3	0.3	1.8
Breast cancer (self-reported)	1.8	2.1	5.2	0.5	-0.9	2.3
Leg fat percentage (left)	1.8	6.4	16.8	0.6	-4.1	1.4
Alcohol intake versus 10 years previously	1.7	2.6	7.3	0.7	0.1	2.7
Blood clot in the leg (DVT)	1.7	2.2	2.9	1.7	1.4	1.3
Leg fat percentage (right)	1.7	6.3	13.9	1.1	-3.7	1.9
Knee pain experienced in last month	1.7	2.7	4.2	1.6	1.2	2.0
Illnesses of father: High blood pressure	1.7	2.1	3.0	-1.7	-1.6	0.9
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	5.0	2.2	0.1	1.1
Major Depression (MDD)	1.6	2.0	3.3	1.6	1.8	0.0
Mouth/teeth dental problems	1.6	2.4	6.8	-0.7	0.1	-2.6
Overall health rating	1.6	3.5	5.5	2.4	1.9	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.4	-0.2	-0.6	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.0	-0.6	1.7	-1.3
Mineral and other dietary supplements	1.6	2.1	3.5	-1.9	-0.2	-1.7
Crohns Disease (2017)	1.5	3.4	7.8	-1.5	-2.8	-0.1
Diabetes (mother)	1.5	1.9	3.2	-1.3	-1.8	-0.9
Had other major operations	1.5	1.9	3.6	-1.9	1.2	-0.9
Body fat percentage	1.5	5.9	8.9	1.8	-3.0	2.4
Mean time to correctly identify matches	1.5	2.8	7.6	0.6	2.8	0.8
Friendships satisfaction	1.5	1.8	4.2	2.0	1.0	0.7
Medication: Atorvastatin	1.5	1.9	5.4	-0.1	-2.3	0.4
Bipolar Disorder or Schizophrenia	1.4	3.3	7.4	1.0	2.7	1.2
Alzheimer’s Disease (in mother)	1.4	1.7	4.0	-0.1	1.0	2.0
Verbal and Numeric Reasoning (VNR)	1.4	3.4	7.7	-2.8	-0.1	-1.6
BMI	1.4	8.2	24.0	-0.7	-4.9	-0.5
Supplements: Zinc	1.4	1.5	2.7	1.1	0.7	1.6
Trunk fat percentage	1.4	5.8	6.9	2.0	-2.6	2.6
Mouth/teeth dental problems: Dentures	1.4	2.3	4.7	2.2	1.5	0.4
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.4	1.1	1.8	0.7
Medication: Paracetamol	1.4	2.4	5.0	1.0	2.2	1.0
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.4	-1.5	-0.2	-2.1
Medication for pain relief, constipation, heartburn	1.4	2.4	3.3	-1.5	-1.8	-1.3
Leg fat mass (right)	1.4	5.6	13.1	1.3	-3.6	1.4
Comparative height size at age 10	1.4	8.0	15.4	2.9	3.9	-0.3
Arm fat percentage (left)	1.4	5.5	6.1	2.2	-2.5	2.4
Average weekly red wine intake	1.4	2.1	4.2	-1.3	-2.1	-0.7
Mood swings	1.4	2.5	5.3	1.3	2.3	0.8
Long-standing illness, disability or infirmity	1.4	2.1	3.9	1.2	2.0	0.9
Age started oral contraceptive pill	1.4	1.7	2.9	-1.7	-1.4	0.4
Leg fat mass (left)	1.4	5.5	14.3	1.0	-3.8	1.1
Alzheimer’s Disease (in father)	1.3	1.5	2.2	-0.4	-1.4	-1.5
Breast Cancer	1.3	3.2	4.6	1.9	2.1	1.1
Crohns Disease (2012)	1.3	2.1	5.9	-0.2	-2.4	0.6
Relative age voice broke	1.3	2.0	5.8	-0.2	0.6	-2.4
Past tobacco smoking	1.3	2.5	4.0	-1.7	-2.0	-0.6
Arm fat percentage (right)	1.3	5.3	5.9	2.4	-2.3	2.2
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.2	0.9	-0.1	2.1
Number of children fathered	1.3	1.5	4.4	-0.1	-0.2	-2.1
Lupus	1.2	1.8	2.7	-1.6	-1.0	-1.2
Sensitivity / hurt feelings	1.2	2.1	3.5	-0.2	1.7	1.9
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.5	-1.6	1.2	-0.8
Body mass index (BMI)	1.2	5.0	14.4	0.2	-3.8	0.8
Number of incorrect matches in round	1.2	1.9	3.4	1.3	1.9	0.7
Medication: Cholesterol lowering	1.2	1.9	3.3	1.8	-0.9	1.2
Medication: Ibuprofen	1.2	1.5	3.8	-0.7	0.2	-2.0
Hearing aid user	1.2	1.4	2.1	-1.5	0.4	1.4
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.3	1.5	1.2	0.9
Angina	1.1	1.5	2.7	-1.0	-1.7	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.8	0.6	1.9	0.4
Trunk fat mass	1.1	4.7	8.2	1.7	-2.9	1.7
Had menopause	1.1	1.4	3.1	0.8	0.6	1.8
Falls in the last year	1.1	1.4	2.0	0.5	1.4	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.3	0.1	1.5	1.2
Medication: Lansoprazole	1.1	1.2	2.1	1.5	0.6	1.1
Loud music exposure frequency	1.1	1.2	1.7	1.3	-0.7	1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	2.9	-1.7	-0.6	-0.7
Whole body fat mass	1.1	4.5	9.2	1.4	-3.0	1.4
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.4	0.3	-1.5	1.2
Medication: Gliclazide	1.1	1.3	2.5	-1.6	-1.0	-0.6
Wears glasses or contact lenses	1.1	1.3	2.1	-1.3	-1.5	-0.1
Impedance of whole body	1.1	5.6	7.7	2.3	2.8	2.0
Height	1.0	18.5	31.2	4.2	5.6	-2.5
Hand grip strength (right)	1.0	2.8	7.5	0.9	-0.1	-2.7
Age when periods started (menarche)	1.0	2.4	5.7	-0.2	-1.2	-2.4
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.0	-1.7	0.1	-0.7
High blood pressure (mother)	1.0	1.4	2.6	-1.6	1.0	0.9
Waist circumference	1.0	3.7	5.3	1.9	-2.3	1.5
Pain all over the body in last month	1.0	1.0	2.8	0.3	1.7	-0.5
Hip circumference	1.0	4.4	12.9	-0.5	-3.6	-0.4
Pulse wave Arterial Stiffness index	1.0	1.1	1.9	0.9	-0.8	-1.4
Medication: Omeprazole	1.0	1.2	2.4	1.5	1.0	0.4
Neuroticism (2016)	0.9	1.3	3.1	0.5	1.8	0.7
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.1	-0.1	-1.5	-1.0
Hearing difficulty/problems: Yes	0.9	1.4	2.0	0.7	1.4	1.3
Medication for hormone replacement therapy	0.9	1.0	1.7	0.2	1.1	-1.3
Stomach or abdominal pain in last month	0.9	1.2	3.1	0.6	1.8	0.0
Supplements: Glucosamine	0.9	1.1	2.4	1.0	-0.2	1.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.9	-1.1	0.6	-1.4
Arm fat mass (right)	0.9	3.6	7.3	1.5	-2.7	1.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.2	-1.8	-0.4	-0.8
Arm fat mass (left)	0.9	3.6	7.8	1.3	-2.8	1.1
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.7	1.1	0.4	1.3
Intelligence (Savage-Jansen 2018)	0.8	2.6	6.3	-2.5	1.2	-0.2
Fasting Glucose	0.8	0.9	1.9	-1.4	-0.2	-0.9
LDL Cholesterol	0.8	1.2	3.2	-0.3	-1.8	-0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.1	1.2	0.9	1.1	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.0	-1.7	-1.5	0.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.0	-0.8	0.9	1.0
Sitting height	0.8	5.7	16.3	-0.7	0.4	-4.0
Noisy workplace	0.8	1.0	1.7	1.3	1.0	0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.9	-0.4	2.2	0.0
Birth weight	0.8	1.7	2.9	1.4	1.7	0.6
Alcohol intake frequency.	0.8	1.8	2.3	1.2	1.3	1.5
Ever had bowel cancer screening	0.8	0.9	1.6	-1.1	0.2	1.3
High cholesterol (Self-reported)	0.8	1.5	1.8	1.2	-1.3	1.1
Risk taking	0.8	1.2	3.5	0.0	1.9	0.2
Fractured/broken bones in last 5 years	0.8	1.0	1.8	-0.9	1.3	-0.7
Commuting to job workplace: Cycle	0.8	1.0	2.2	-1.5	0.1	-0.9
Myopia	0.8	1.1	2.1	0.8	-0.8	-1.4
Hand grip strength (left)	0.7	1.9	4.9	0.9	0.2	-2.2
Maternal smoking around birth	0.7	1.0	1.6	1.3	0.2	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.0	-1.2	-1.7	0.5
Exposure to tobacco smoke at home	0.7	0.7	1.3	1.2	0.6	0.7
Pulse wave reflection index	0.7	0.8	2.4	1.6	-0.0	0.2
Shortness of breath walking on level ground	0.7	0.8	1.5	0.6	1.2	-0.7
Eye problems/disorders: None of the above	0.7	0.8	1.2	0.8	0.8	-1.1
Angina (self-reported)	0.7	0.9	1.7	-0.7	-1.3	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.8	-0.1	0.8	-1.3
Alcohol drinker status: Never	0.7	0.8	1.3	-0.0	1.1	1.1
Average weekly beer plus cider intake	0.7	1.0	1.3	1.1	0.8	1.1
Cardiovascular Disease	0.6	2.1	3.5	1.6	0.4	1.9
Medication: Atenolol	0.6	0.8	1.4	0.5	-1.2	0.8
Number of live births	0.6	0.8	2.2	0.6	1.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.2	0.2	1.1	-1.0
Lung cancer (father)	0.6	0.7	1.3	-0.3	-1.1	0.8
Pulse wave peak to peak time	0.6	0.7	0.9	-0.9	0.7	0.9
Medication: Blood pressure	0.6	1.0	3.0	0.2	0.2	1.7
Osteoarthritis (self-reported)	0.6	0.8	1.9	0.3	0.6	1.4
Medication: Bendroflumethiazide	0.6	0.9	2.5	0.5	0.3	1.6
Number of operations (self-reported)	0.6	0.9	1.4	-0.6	1.2	0.9
Vascular/heart problems diagnosed by doctor	0.6	1.5	3.6	-0.9	-0.2	-1.9
Age at First Birth	0.5	0.8	2.0	0.4	-1.4	0.3
Coronary Artery Disease (CAD)	0.5	0.6	0.9	-1.0	-0.4	0.9
HbA1C	0.5	0.5	1.5	-1.2	0.2	-0.0
Schizophrenia (2014)	0.5	1.1	3.1	0.4	0.4	1.8
Triglycerides	0.5	0.8	2.0	1.4	0.7	-0.1
Systolic Blood Pressure	0.5	2.3	3.1	1.8	1.8	0.8
Ever had hysterectomy (womb removed)	0.5	0.5	1.5	-1.2	-0.3	0.1
Diabetes (father)	0.5	0.6	1.6	-1.3	-0.4	0.2
Medication: Ramipril	0.5	0.6	1.8	-0.1	-1.3	0.1
Fluid intelligence score	0.5	1.0	2.9	-1.7	-0.1	-0.3
Weight	0.5	2.3	6.0	1.0	-2.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.6	-1.6	-0.5	-1.4
Glaucoma (self-reported)	0.5	0.6	1.2	0.6	-1.1	0.5
Comparative body size at age 10	0.5	1.4	1.8	-1.3	-1.3	-0.9
Health satisfaction	0.5	0.7	1.3	1.2	0.8	0.1
Arm predicted mass (right)	0.5	2.5	4.4	-1.1	-2.1	-1.4
Illnesses of siblings: Diabetes	0.5	0.7	0.8	-0.8	-0.8	0.9
Smoking status: Previous	0.5	0.7	1.6	0.7	1.3	0.2
Eye problems/disorders: Cataract	0.5	0.6	0.9	-1.0	-0.6	0.8
Illnesses of father: None of the above (group 1)	0.5	0.7	1.3	0.6	-1.1	-0.5
Medication: Paracetamol	0.5	0.8	2.4	-0.3	1.6	-0.2
Arm fat-free mass (left)	0.5	2.4	4.0	-0.4	-2.0	-1.7
Diastolic blood pressure, automated reading	0.5	1.5	3.0	1.7	0.2	1.2
Unable to work because of sickness or disability	0.5	0.6	1.7	0.4	1.3	0.3
Heart disease (siblings)	0.5	0.6	1.4	-1.2	0.7	0.2
Arm predicted mass (left)	0.5	2.8	4.2	-0.6	-2.0	-1.9
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	0.9	0.2	1.2
Relative age of first facial hair	0.4	0.8	2.2	-0.1	-0.2	-1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	-0.2	-0.5	1.0
Financial difficulties in last 2 years	0.4	0.6	1.4	0.5	1.2	0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.6	-1.6	-0.4	-0.9
Pulse rate	0.4	0.7	1.6	-0.3	0.7	-1.3
Trunk predicted mass	0.4	2.0	4.8	0.0	-1.1	-2.2
Arm fat-free mass (right)	0.4	2.1	3.8	-0.8	-2.0	-1.4
Number of full sisters	0.4	0.5	1.2	1.1	-0.3	-0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-0.6	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.1	-0.0	-0.3	-1.4
Osteoporosis (self-reported)	0.4	0.5	1.5	0.0	-0.2	1.2
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	1.1	-0.3	0.6
Medication: Blood pressure	0.4	0.7	1.1	1.0	1.1	0.4
Medication: Lisinopril	0.4	0.5	1.2	-1.1	-0.1	0.6
Irritability	0.4	0.7	1.8	-1.3	0.6	0.2
Schizophrenia (2018)	0.3	0.6	1.0	0.3	0.8	1.0
Rheumatoid Arthritis	0.3	0.5	0.8	-0.3	0.7	0.9
Blood Platelet Count	0.3	3.2	5.4	-1.9	-2.3	-0.9
Heel T-Score	0.3	2.8	5.3	-0.5	-2.3	1.7
Impedance of leg (right)	0.3	1.6	1.7	1.3	1.3	1.2
High blood pressure	0.3	0.9	2.3	0.5	0.4	1.5
Medication: Levothyroxine sodium	0.3	0.4	1.2	0.2	1.1	-0.2
Illnesses of siblings	0.3	0.4	0.6	0.8	-0.4	-0.7
Trunk fat-free mass	0.3	2.0	4.8	0.1	-1.1	-2.2
Standing height	0.3	3.2	5.2	1.6	2.3	-1.4
Breastfed as a baby	0.3	0.4	1.0	1.0	-0.2	0.4
High blood pressure (siblings)	0.3	0.4	1.1	-0.0	0.4	1.0
Number of full brothers	0.3	0.4	0.5	0.6	0.7	-0.4
Pulse rate, automated reading	0.3	1.1	2.4	0.1	1.0	-1.6
Leg pain on walking	0.3	0.4	0.6	-0.7	0.7	-0.4
Hypertension (Self-reported)	0.3	1.0	1.6	1.0	0.5	1.3
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.2	0.7	-0.6
Medication for cholesterol	0.3	0.4	0.7	-0.7	-0.8	0.4
Commuting to job workplace: Public transport	0.3	0.4	1.2	0.0	1.1	0.2
Basal metabolic rate	0.3	1.4	2.9	0.5	-1.7	-1.1
Supplements: Calcium	0.3	0.3	0.5	0.7	-0.7	0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.3	-0.0	0.9
Ovarian Cancer	0.2	0.3	0.5	-0.5	-0.7	0.3
Hair Pigment	0.2	4.7	9.3	3.0	2.2	-0.0
Tanning	0.2	3.0	5.7	1.4	2.4	1.1
Leg fat-free mass (left)	0.2	0.9	1.8	1.3	-0.9	0.1
Average weekly fortified wine intake	0.2	0.2	0.4	0.5	0.6	-0.3
Leg predicted mass (left)	0.2	1.0	1.9	1.4	-1.0	0.2
Hearing difficulty/problems with background noise	0.2	0.3	0.8	0.1	0.5	0.9
Heart attack	0.2	0.2	0.6	0.4	0.0	0.8
Prospective memory result	0.2	0.2	0.5	0.5	0.2	-0.7
Peak expiratory flow (PEF)	0.2	0.5	1.3	-0.2	1.1	0.3
Qualifications: College or University degree	0.2	0.7	1.3	-1.1	0.5	-0.7
Whole body fat-free mass	0.2	1.4	2.3	0.3	-1.3	-1.5
Whole body water mass	0.2	1.4	2.2	0.3	-1.3	-1.5
Leg predicted mass (right)	0.2	0.8	1.6	0.8	-1.2	-0.4
Mother’s age at death	0.2	0.3	0.7	0.2	0.8	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	0.1	0.2	0.9
Alcohol drinker status: Previous	0.2	0.2	0.7	0.8	-0.1	0.0
Mean Putamen Volume	0.1	0.1	0.2	-0.5	-0.4	0.0
Hypothyroidism (self reported)	0.1	0.2	0.3	0.4	0.1	0.6
Lung FVC	0.1	0.7	1.7	-0.3	-0.6	1.3
Systolic blood pressure, automated reading	0.1	0.2	0.3	0.5	-0.0	0.5
Medication: Metformin	0.1	0.2	0.3	0.6	0.2	0.3
Qualifications: CSEs or equivalent	0.1	0.2	0.5	0.2	0.1	0.7
Impedance of leg (left)	0.1	0.3	0.4	0.5	0.6	0.5
Forced vital capacity (FVC)	0.1	0.3	0.5	0.1	0.7	-0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.3	-0.6	-0.3
Length of working week for main job	0.1	0.1	0.3	-0.2	-0.1	-0.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	-0.4	-0.5	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.7	0.0	0.2
Medication: Amlodipine	0.1	0.2	0.3	0.2	-0.6	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.4	0.6	0.3	0.7	-0.8
Age at first live birth	0.1	0.2	0.5	0.0	-0.3	-0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.5	-0.2	-0.0
Age at last live birth	0.1	0.1	0.1	0.4	0.3	0.3
Medication: Aspirin	0.1	0.1	0.3	0.1	0.6	-0.0
Leg fat-free mass (right)	0.1	0.8	1.3	0.9	-1.1	-0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.4	-0.1	-0.3
Back pain experienced in last month	0.1	0.2	0.3	0.1	0.4	0.6
Medication: Aspirin	0.1	0.2	0.3	0.5	0.4	0.1
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.3	-0.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	-0.6	0.1	-0.2
Cholesterol lowering medication	0.1	0.1	0.2	0.4	0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.4	0.3	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.0	0.1	0.3	-0.2	0.0

Hub : Genes

THRA

Models

Trait associations