Hub : Genes

RPL23

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0975	0.0390	0.0096	0.008	NA	0.015	NA	0.009	0.072	NA	0.023	NA	0.06
2	TCGA	Brain Lower Grade Glioma	0.0530	0.0272	0.0024	0.020	-0.002	-0.002	NA	0.002	0.002	0.6800	0.870	NA	0.18
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.1000	0.0600	0.0039	-0.003	0.033	0.035	NA	0.003	0.580	0.0024	0.002	NA	0.20

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.3	2.2	-1.2	-0.3	1.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.2	-0.7	0.0
Depressed Affect (Nagel 2018)	0.1	0.1	0.1	0.4	0.4	0.3
Depression (Nagel 2018)	0.4	0.6	1.5	1.2	-0.5	-0.0
Intelligence (Savage-Jansen 2018)	0.3	1.1	2.7	-0.3	1.6	0.6
Neuroticism (Nagel 2018)	0.1	0.1	0.3	0.4	-0.1	-0.5
Schizophrenia (2018)	0.4	0.9	1.6	0.8	-0.7	-1.3
Schizophrenia vs Biploar Disorder	0.5	0.7	1.2	1.1	-0.8	-0.5
Worry (Nagel 2018)	0.5	1.0	1.5	0.6	-1.0	-1.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.4	-0.2	0.2
Alzheimer’s Disease (in father)	0.6	0.6	1.0	-1.0	0.1	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.7	1.2	-0.2	-1.1	-0.9
Crohns Disease (2017)	0.4	0.8	1.2	-1.1	0.8	0.9
Irritable Bowel Disease (IBD)	0.5	1.1	1.6	-0.7	1.3	1.1
Ulcerative Colitis (UC)	0.5	0.9	1.8	-0.6	1.4	0.8
Major Depression (MDD)	0.4	0.5	1.2	-0.2	-1.1	0.6
Reaction Time	0.3	0.5	1.2	1.1	0.4	-0.2
Verbal and Numeric Reasoning (VNR)	1.1	2.5	4.5	-1.5	2.1	0.8
Breast Cancer	0.3	0.7	2.1	-1.4	0.2	-0.2
Ovarian Cancer	1.1	1.4	2.5	-1.6	0.6	-1.2
Prostate Cancer	0.7	0.9	2.1	0.6	1.4	-0.6
Age at First Birth	0.8	1.2	3.1	-1.8	-0.6	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.8	0.3	-0.1
Coronary Artery Disease (CAD)	1.7	2.0	3.8	1.9	-0.8	1.3
Crohns Disease (2012)	0.9	1.4	2.3	-0.6	1.5	1.2
Mean Putamen Volume	1.2	1.4	2.4	1.6	-0.4	-1.3
Fasting Glucose	0.3	0.3	0.9	-1.0	0.1	-0.1
HbA1C	1.5	1.7	3.8	-2.0	0.9	-0.5
HDL Cholesterol	2.8	4.7	12.4	-3.5	1.0	0.9
LDL Cholesterol	0.4	0.6	1.4	-0.7	-1.2	-0.2
Lupus	1.5	2.2	5.5	-1.1	-2.3	0.0
Neuroticism (2016)	0.2	0.3	0.7	-0.4	0.2	-0.9
Primary Biliary Cirrhosis	2.4	3.5	6.1	1.9	0.7	2.5
Rheumatoid Arthritis	2.0	2.7	5.9	1.4	-0.7	2.4
Schizophrenia (2014)	0.3	0.6	1.3	0.6	-1.2	-0.1
Triglycerides	0.1	0.2	0.3	-0.0	-0.6	-0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.4	-0.0	-0.3	0.6
Ulcerative Colitis	1.6	2.4	6.9	-0.3	2.6	0.5
Blood Eosinophil Count	0.3	2.1	5.8	-2.4	0.3	-0.6
Blood Platelet Count	0.8	9.3	15.4	-3.2	-3.9	1.5
Blood Red Count	0.1	0.7	1.2	-0.7	0.7	1.1
Blood White Count	0.3	2.6	6.3	-0.5	-1.1	2.5
Heel T-Score	1.1	8.8	23.2	1.7	-0.6	4.8
BMI	0.1	0.3	0.7	0.8	0.5	-0.2
Height	1.0	19.6	57.9	-0.5	-0.9	-7.6
Waist Hip Ratio (WHR)	1.3	5.9	16.4	-0.2	-1.1	4.0
Systolic Blood Pressure	1.4	6.9	17.9	1.3	-4.2	1.1
Smoking Status	0.5	1.1	2.9	1.7	-0.4	0.6
Allergy or Eczema	0.1	0.4	0.8	-0.5	0.9	0.2
Cardiovascular Disease	0.2	0.7	0.9	1.0	-0.5	1.0
Hypothyroidism (self reported)	0.5	1.1	3.1	1.8	-0.5	0.3
Respiratory disease	0.5	1.0	1.6	1.2	-0.9	-0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.0	-0.3	1.4	0.4
Lung FEV1/FVC ratio	2.2	11.1	17.7	1.7	-3.5	4.2
Lung FVC	0.1	0.3	0.4	-0.5	0.7	-0.4
Neuroticism	0.3	0.7	1.5	0.1	-0.8	-1.2
Chronotype (morning person)	0.2	0.4	0.7	0.9	-0.8	-0.0
Hair Pigment	0.1	3.7	9.9	0.3	1.0	3.1
Tanning	0.0	0.1	0.3	0.6	-0.1	0.2
Hand grip strength (left)	1.4	3.6	6.7	0.6	-2.6	-1.9
Number of treatments/medications taken	0.7	1.3	3.3	0.4	0.7	-1.8
Average weekly spirits intake	0.1	0.1	0.4	0.6	-0.0	-0.1
Sensitivity / hurt feelings	1.3	2.2	3.3	1.7	0.7	-1.8
Frequency of depressed mood in last 2 weeks	1.0	1.5	2.5	0.9	-1.6	-1.1
Hearing difficulty/problems: Yes	0.4	0.7	1.6	1.3	-0.4	-0.5
Relative age of first facial hair	0.6	1.1	2.7	-0.0	1.6	0.8
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.8	1.9	-1.1	-0.3
Ever used hormone-replacement therapy (HRT)	2.4	3.1	8.6	2.9	0.1	-0.8
Ever had hysterectomy (womb removed)	0.3	0.4	0.8	-0.4	0.5	0.9
Systolic blood pressure, automated reading	1.0	2.9	5.0	-1.3	-2.2	1.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.5	0.4	0.7	0.6
Angina	1.7	2.2	3.7	-0.3	-1.9	-1.7
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.1	0.2	0.5
Vitamin and mineral supplements	0.5	0.7	1.2	1.0	-0.0	1.1
Supplements: Zinc	1.2	1.3	2.6	-0.2	-1.1	-1.6
Medication: Co-codamol	1.1	1.3	3.1	-0.8	-1.7	0.4
Medication: Metformin	0.7	1.0	2.1	-0.0	1.4	0.9
Diabetes (father)	0.6	0.7	1.2	1.1	-0.6	-0.7
Diabetes (mother)	0.5	0.7	1.8	0.4	-1.3	-0.3
Severe depression (siblings)	0.1	0.1	0.1	-0.2	-0.3	0.1
Pack years adult smoking proportion	0.1	0.2	0.5	0.2	0.7	-0.3
Impedance of leg (right)	0.7	3.6	7.6	-0.6	-1.7	2.8
Leg fat-free mass (left)	0.7	3.9	11.1	0.7	-0.3	-3.3
Trunk fat percentage	0.2	0.6	1.9	-0.1	-1.4	0.0
Hand grip strength (right)	1.8	4.9	9.5	1.3	-3.1	-1.9
Townsend deprivation index at recruitment	0.6	0.8	1.7	0.4	1.3	-0.7
Current tobacco smoking	0.0	0.0	0.1	-0.2	-0.1	0.2
Average weekly fortified wine intake	1.2	1.4	3.2	0.7	1.8	0.8
Maternal smoking around birth	0.3	0.5	1.1	-0.2	-1.0	-0.6
Fed-up feelings	0.1	0.1	0.2	0.4	-0.1	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.7	1.3	0.1	-0.6
Relative age voice broke	0.2	0.3	0.6	-0.3	0.5	-0.7
Taking other prescription medications	1.4	2.1	3.6	1.9	0.9	-1.4
Age when periods started (menarche)	0.2	0.5	0.8	0.7	-0.4	0.9
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	5.7	2.4	-0.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	6.0	-0.1	-1.3	2.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.1	0.1	0.6	1.0
Qualifications: CSEs or equivalent	0.9	1.2	2.5	0.9	-0.5	-1.6
Serious illness, injury or assault to yourself	0.6	0.8	1.2	1.1	-1.1	0.0
High blood pressure	0.1	0.2	0.5	-0.0	0.7	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	-0.8	1.3	0.2
Multivitamins +/- minerals	0.5	0.6	1.5	-1.2	0.3	-0.5
Stomach or abdominal pain in last month	0.3	0.4	0.7	-0.5	0.6	-0.9
Supplements: Glucosamine	2.6	3.3	7.3	2.7	-1.4	0.9
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	2.6	1.5	-1.6	-0.5
Medication: Atenolol	0.0	0.1	0.1	0.1	0.3	-0.3
Medication: Levothyroxine sodium	0.7	1.1	2.9	1.7	0.7	0.2
Sitting height	0.5	3.7	10.1	1.0	0.1	-3.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	0.1	-1.1	-0.7
High blood pressure (mother)	0.4	0.6	1.0	0.9	0.1	-1.0
Body mass index (BMI)	0.0	0.1	0.2	0.1	0.0	-0.5
Impedance of leg (left)	0.8	3.8	8.2	-0.7	-1.6	2.9
Leg predicted mass (left)	0.7	3.8	10.9	0.7	-0.3	-3.3
Trunk fat mass	0.2	0.8	1.5	0.2	-1.2	-1.0
Waist circumference	0.0	0.0	0.0	0.2	-0.0	0.1
Number of incorrect matches in round	0.6	1.0	1.8	0.8	-0.6	-1.3
Past tobacco smoking	0.7	1.3	3.8	-1.9	0.5	0.2
Alcohol usually taken with meals	1.7	2.8	5.9	1.2	2.4	-1.1
Nervous feelings	0.7	1.3	3.3	0.8	0.2	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.7	-0.2	-0.8	0.2
Hearing difficulty/problems with background noise	1.2	2.0	2.7	1.6	0.9	1.5
Hair/balding pattern: Pattern 2	2.6	3.3	8.7	3.0	-0.9	-0.5
Had menopause	1.8	2.3	4.2	0.5	1.5	2.0
Had other major operations	1.4	1.7	2.6	1.4	0.9	1.6
Forced vital capacity (FVC)	0.5	1.9	2.2	1.4	-1.2	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	5.2	-0.4	-1.0	2.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	1.4	0.0	0.3
Qualifications: None of the above	0.3	0.7	1.2	-1.1	-0.7	-0.7
Financial difficulties in last 2 years	0.7	1.0	1.4	1.2	-1.1	0.6
Mouth/teeth dental problems	1.2	1.9	5.4	0.1	2.3	0.6
Heart attack	1.0	1.2	2.5	-0.7	-1.6	0.9
Allergy	0.0	0.1	0.2	0.0	-0.2	0.4
Pain all over the body in last month	0.9	0.9	2.3	-0.3	-1.5	-0.7
Diabetes (self-reported)	1.3	1.9	5.8	-0.1	2.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.2	-1.8	-0.2	-0.4
Medication: Ramipril	0.3	0.4	0.7	-0.1	0.8	-0.8
Medication: Simvastatin	0.2	0.3	0.5	-0.3	-0.7	-0.5
Fluid intelligence score	1.3	2.8	8.2	0.2	2.9	0.3
Illnesses of siblings	0.6	0.9	1.7	1.3	-0.3	1.0
Neuroticism score	0.4	0.8	2.0	0.3	-0.4	-1.4
Weight	0.5	2.4	6.7	0.6	-0.6	-2.6
Impedance of arm (right)	0.2	0.8	1.3	-0.0	-1.2	1.0
Arm fat percentage (right)	0.1	0.2	0.5	0.3	-0.7	-0.2
Trunk fat-free mass	1.0	6.0	16.9	1.1	-0.0	-4.1
Hip circumference	0.3	1.4	2.7	-0.0	1.2	-1.6
Time employed in main current job	1.2	1.4	2.8	-1.7	0.5	-1.1
Alcohol intake versus 10 years previously	0.8	1.2	2.1	1.4	0.1	1.2
Father’s age at death	0.4	0.6	1.1	1.0	-0.3	0.8
Worrier / anxious feelings	0.9	1.8	2.7	1.6	-1.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	1.2	-0.4	-0.3
Falls in the last year	0.4	0.5	0.8	-0.3	0.8	-0.9
Hair/balding pattern: Pattern 3	1.2	1.8	2.8	-1.6	0.4	-1.7
Number of live births	0.2	0.2	0.6	0.8	-0.3	0.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.1	1.5	-2.0	-0.3
Pulse rate	0.2	0.4	0.8	0.9	0.1	-0.6
Happiness	0.8	0.9	1.7	0.7	-1.3	-0.8
Noisy workplace	0.4	0.5	1.3	-0.1	0.4	-1.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	-0.2	1.1	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.6	0.2	0.8	0.7
Mouth/teeth dental problems: Dentures	1.7	2.9	7.9	0.4	-2.8	-0.8
Asthma	0.8	1.5	2.6	1.6	-0.9	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.5	0.3	-0.3
Medication: Cholesterol lowering	0.3	0.5	1.1	-0.2	-1.1	-0.6
Depression (self-reported)	1.0	1.2	2.1	-0.8	-1.0	-1.4
Medication: Lansoprazole	0.2	0.3	0.7	0.9	0.3	0.2
Prospective memory result	0.4	0.5	1.2	-1.1	-0.6	-0.3
Lung cancer (father)	1.5	1.8	4.1	1.2	2.0	0.1
Illnesses of mother	0.1	0.1	0.2	0.3	0.5	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	6.1	2.5	-1.9	-0.7
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	0.1	-0.1	0.1
Impedance of arm (left)	0.2	1.0	1.8	0.0	-1.3	1.1
Arm fat mass (right)	0.2	0.9	1.6	0.8	-0.8	-1.3
Trunk predicted mass	1.0	5.9	16.6	1.1	0.0	-4.1
Standing height	0.8	8.1	21.3	1.2	-1.2	-4.6
Length of working week for main job	0.3	0.3	0.9	0.0	-0.3	1.0
Exposure to tobacco smoke at home	0.9	1.0	1.5	-1.0	-0.8	1.2
Breastfed as a baby	1.4	1.8	4.6	-0.7	2.1	-0.4
Tense / ‘highly strung’	0.3	0.4	0.6	0.8	-0.8	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	5.6	-0.4	-2.0	-2.4
Hair/balding pattern: Pattern 4	0.5	1.3	3.7	-1.9	-0.4	0.3
Birth weight of first child	0.2	0.4	0.5	-0.4	0.7	-0.7
Peak expiratory flow (PEF)	1.1	2.5	5.0	1.1	-2.2	1.2
Pulse wave reflection index	1.1	1.3	2.5	-1.2	0.1	1.6
Ever highly irritable/argumentative for 2 days	1.0	1.1	2.1	1.1	-1.4	-0.4
Loud music exposure frequency	1.0	1.1	3.1	1.8	0.5	-0.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	4.1	0.6	2.0	-0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	0.3	0.8	-0.1
Blood clot in the leg (DVT)	1.1	1.4	2.7	1.2	0.4	1.6
Medication: Paracetamol	0.6	1.1	2.7	-0.3	-1.7	0.6
Headache pain in last month	0.1	0.1	0.3	-0.1	-0.0	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	-0.5	-0.2	-0.9
Glaucoma (self-reported)	0.9	1.1	3.2	0.1	-0.3	1.8
Gout (self-reported)	1.0	1.4	3.6	0.5	1.9	0.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.7	2.2	-0.1	0.4
Medication: Amlodipine	0.9	1.3	3.8	-0.2	2.0	-0.1
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	0.1	0.2	-0.2
Birth weight	0.1	0.2	0.2	-0.4	0.4	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.6	-0.8	0.6	-0.5
High blood pressure (siblings)	0.2	0.2	0.7	-0.9	-0.0	-0.0
Forced vital capacity (FVC), Best measure	0.9	3.3	4.7	2.2	-1.1	-2.0
Body fat percentage	0.2	0.6	1.6	-0.1	-1.2	0.5
Leg fat percentage (right)	0.2	0.7	1.2	-0.3	-1.1	0.9
Arm fat-free mass (right)	0.5	2.5	7.3	0.4	-0.1	-2.7
Exposure to tobacco smoke outside home	0.1	0.1	0.4	-0.1	-0.7	-0.1
Comparative body size at age 10	0.7	1.9	3.5	0.1	-1.5	-1.9
Number of full brothers	1.9	2.4	7.1	0.0	-2.7	-0.2
Worry too long after embarrassment	0.4	0.7	2.0	-0.3	1.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.9	-0.2	-0.2	-1.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.4	0.6	-0.5	-0.5
Number of children fathered	1.8	2.1	5.9	0.6	-2.4	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	0.5	0.5	0.3
Age at first live birth	0.1	0.2	0.6	0.8	-0.0	0.2
Pulse wave peak to peak time	0.1	0.1	0.2	-0.0	-0.1	-0.5
Health satisfaction	0.5	0.6	1.5	1.2	0.6	-0.1
Shortness of breath walking on level ground	1.5	1.8	3.0	1.7	-1.4	-0.5
Qualifications: College or University degree	0.5	1.6	3.4	-1.0	0.7	1.9
Eye problems/disorders: None of the above	0.5	0.5	0.9	0.7	-0.9	-0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	0.7	-1.2	0.5
Emphysema/chronic bronchitis	0.8	0.9	1.3	1.1	0.5	-1.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	0.8	0.1	1.2
Neck or shoulder pain in last month	0.5	0.6	1.1	-0.6	0.7	1.0
Medication: Blood pressure	0.3	0.6	1.1	0.8	0.3	1.0
Angina (self-reported)	1.7	2.3	3.7	-0.0	-1.9	-1.8
Migraine (self-reported)	1.3	1.6	4.8	-0.3	-2.2	-0.3
Medication: Ibuprofen	0.2	0.2	0.4	0.6	0.5	0.3
Medication: Allopurinol	1.8	2.4	6.2	1.0	2.5	-0.4
Medication: Omeprazole	2.3	2.8	6.7	1.0	-0.8	-2.6
Medication: Seretide 50 evohaler	1.3	1.5	3.5	1.9	0.3	0.9
Mean time to correctly identify matches	0.2	0.4	0.9	0.9	0.4	0.3
Heart disease (mother)	0.6	0.7	1.0	-0.7	1.0	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	1.0	0.9	0.2
Whole body fat mass	0.1	0.6	1.3	0.3	-1.1	-0.6
Leg fat mass (right)	0.1	0.3	0.9	0.1	-0.9	-0.1
Arm predicted mass (right)	0.6	3.0	8.9	0.3	0.0	-3.0
Pulse rate, automated reading	0.2	0.8	2.0	-0.4	0.3	-1.4
Alcohol intake frequency.	0.6	1.4	3.1	0.6	-1.8	-0.8
Comparative height size at age 10	0.9	4.9	13.0	1.0	-0.8	-3.6
Number of full sisters	1.1	1.4	3.7	0.2	1.9	0.6
Suffer from ‘nerves’	0.2	0.4	1.0	0.2	1.0	0.2
Overall health rating	0.4	0.9	1.8	1.0	-0.3	-1.3
Chest pain or discomfort	0.8	1.2	3.4	-0.4	0.4	-1.8
Had major operations	1.9	2.2	3.3	1.6	0.8	-1.8
Age at last live birth	0.6	0.8	1.7	0.8	0.4	1.3
Family relationship satisfaction	0.2	0.2	0.5	0.7	-0.3	-0.0
Leg pain on walking	0.3	0.4	0.7	0.5	-0.8	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.7	1.3	-0.9	-1.0
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.0	-1.4	-1.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.6	-0.4	1.3	-0.8
Medication: Aspirin	0.4	0.5	0.8	-0.8	0.1	-0.9
Supplements: Vitamin C	0.3	0.3	0.7	-0.1	0.4	-0.8
Knee pain experienced in last month	0.5	0.8	2.1	0.6	-1.5	0.1
Hypertension (Self-reported)	0.1	0.3	0.6	-0.1	0.8	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	0.3	0.3	-0.0
Illnesses of father: Heart disease	0.4	0.5	1.3	-1.1	-0.3	-0.3
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.9	-0.4	-0.0
Smoking status: Previous	1.2	1.8	4.7	2.2	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	9.1	1.2	-1.6	-3.0
Whole body fat-free mass	0.9	5.2	14.4	1.0	-0.2	-3.8
Leg fat-free mass (right)	0.8	4.4	12.5	0.8	-0.2	-3.5
Arm fat percentage (left)	0.0	0.2	0.5	0.1	-0.7	0.0
Average weekly red wine intake	0.1	0.2	0.5	-0.7	-0.0	0.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.5	-0.1	1.2	-1.2
Mood swings	0.1	0.2	0.4	0.6	0.0	-0.2
Loneliness, isolation	0.6	0.8	2.1	-0.0	0.5	1.5
Long-standing illness, disability or infirmity	0.3	0.4	1.0	1.0	-0.3	-0.4
Ever had bowel cancer screening	1.1	1.2	3.4	0.1	1.8	-0.6
Diabetes diagnosed by doctor	1.4	2.3	6.6	-0.5	2.6	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.8	0.3	-0.7
Friendships satisfaction	0.5	0.6	1.2	-0.5	0.5	1.1
Qualifications: nursing, teaching	1.1	1.8	2.2	1.2	1.3	1.5
Commuting to job workplace: Walk	0.2	0.2	0.5	0.7	-0.1	-0.2
Eye problems/disorders: Cataract	1.1	1.3	3.2	-0.1	-0.8	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	-0.1	-0.8	-0.7
Medication for cholesterol	0.3	0.5	1.2	0.3	0.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.3	0.1	-0.5
Back pain experienced in last month	0.9	1.3	2.2	1.5	0.7	-1.1
Mineral and other dietary supplements	0.3	0.3	1.0	-0.1	1.0	-0.2
Breast cancer (self-reported)	0.9	1.1	2.5	-0.2	1.6	-0.8
Asthma (self-reported)	0.9	1.7	2.7	1.6	-1.0	-1.1
Osteoporosis (self-reported)	0.4	0.5	0.9	-0.6	0.9	-0.6
Osteoarthritis (self-reported)	1.6	2.1	2.8	1.7	-0.9	1.6
Medication: Aspirin	0.3	0.4	1.0	-0.4	-0.0	-1.0
Medication: Gliclazide	0.2	0.2	0.4	-0.5	0.6	0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	0.3	1.0	0.7
Smoking status: Current	0.0	0.0	0.0	-0.2	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.6	-0.6	0.2
Whole body water mass	0.9	5.4	15.2	0.9	-0.2	-3.9
Leg predicted mass (right)	0.9	4.6	13.0	0.8	-0.2	-3.6
Arm fat mass (left)	0.2	0.6	1.0	0.6	-0.8	-1.0
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	1.1	0.5	0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.2	0.9	-0.2
Miserableness	0.3	0.5	1.0	0.6	1.0	0.2
Guilty feelings	0.1	0.1	0.1	0.3	-0.1	-0.4
Wears glasses or contact lenses	0.4	0.4	0.9	1.0	0.4	-0.4
Ever taken oral contraceptive pill	1.6	1.8	4.8	2.2	-0.5	-0.5
Hearing aid user	0.2	0.3	0.7	-0.1	0.8	0.2
Mother’s age at death	0.2	0.3	0.4	0.4	-0.6	-0.5
Financial situation satisfaction	0.2	0.3	0.5	0.7	0.2	-0.5
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.0	1.7	-1.2	-0.5
Commuting to job workplace: Public transport	1.5	1.8	4.0	2.0	0.9	0.7
Eye problems/disorders: Glaucoma	1.3	1.5	4.4	0.1	0.4	2.1
Medication: Blood pressure	0.5	0.9	2.1	-0.5	0.5	-1.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.4	0.8	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.8	-0.7	-0.1
High cholesterol (Self-reported)	0.1	0.1	0.2	0.1	-0.3	-0.5
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.8	0.4	0.1
Medication: Paracetamol	0.4	0.6	1.4	-0.6	-1.2	0.3
Medication: Lisinopril	0.2	0.3	0.3	0.5	-0.5	-0.6
Medication: Atorvastatin	0.4	0.5	0.5	-0.7	0.6	-0.7
Illnesses of father: High blood pressure	2.1	2.6	4.0	1.9	-2.0	0.1
Alcohol drinker status: Never	0.8	1.0	1.6	-1.3	-0.6	1.0
Ever smoked	0.4	0.6	1.0	1.0	0.4	-0.8
Basal metabolic rate	0.8	4.7	13.2	0.8	-0.4	-3.6
Leg fat percentage (left)	0.2	0.6	0.9	-0.2	-0.9	0.9
Arm fat-free mass (left)	0.8	3.9	11.2	0.8	0.1	-3.3
Number of operations (self-reported)	0.7	1.1	1.5	1.0	1.2	-0.9
Average weekly beer plus cider intake	0.6	0.8	2.4	-1.5	0.2	0.2
Irritability	1.0	1.7	2.5	-1.6	-1.2	-1.1
Risk taking	0.9	1.3	2.5	1.0	-1.6	0.6
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.4	-0.5	0.2	-2.1
Fractured/broken bones in last 5 years	0.6	0.8	1.9	0.6	0.3	-1.4
Age started oral contraceptive pill	0.4	0.5	0.8	0.9	-0.8	0.3
Diastolic blood pressure, automated reading	0.4	1.2	2.7	-0.6	-0.8	1.6
Ever depressed for a whole week	1.0	1.3	1.9	1.0	-1.0	-1.4
Unable to work because of sickness or disability	1.2	1.6	3.1	-0.9	-1.8	0.9
Commuting to job workplace: Cycle	0.5	0.6	1.2	-1.1	0.6	0.4
Myopia	0.2	0.3	0.8	-0.1	0.9	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	0.0	-0.7	0.4
Cholesterol lowering medication	0.3	0.5	1.1	-0.4	0.4	-1.1
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	7.0	0.9	-1.1	-2.6
Pain experienced in last month	0.5	0.8	1.4	0.5	-1.2	-0.9
Supplements: Calcium	1.1	1.2	2.1	-1.3	1.4	0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.1	0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.9	-0.8	-1.4	0.9
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.7	1.4	0.3	1.6
Heart disease (siblings)	0.9	1.1	2.4	1.5	0.6	-0.7
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.9	-0.3	0.1
Pack years of smoking	0.3	0.5	1.3	0.3	1.1	-0.1
Impedance of whole body	0.6	2.9	6.8	-0.3	-1.4	2.6
Leg fat mass (left)	0.1	0.3	0.9	-0.0	-0.9	-0.1
Arm predicted mass (left)	0.7	3.7	10.4	0.8	-0.3	-3.2