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chr20:2,390,880-5,876,691

Best TWAS P=6e-23 · Best GWAS P=5.27e-57 conditioned to 1.59e-53

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C20orf194	0.19	0.12	enet	48	0.17	9.6e-20	7.8	8.3	8.8e-17	0.03	0.02	0.98	TRUE
2	GTEx	Adipose Subcutaneous	PANK2	0.11	0.00	enet	16	0.02	1.5e-02	2.7	-5.2	2.4e-07	-0.22	0.10	0.32	FALSE
3	GTEx	Adrenal Gland	ITPA	0.38	0.37	enet	37	0.38	1.4e-14	3.9	-5.9	3.3e-09	0.01	0.88	0.12	FALSE
4	GTEx	Artery Aorta	C20orf194	0.16	0.05	lasso	3	0.03	6.4e-03	-5.1	6.0	2.2e-09	-0.06	0.06	0.68	FALSE
5	GTEx	Artery Tibial	PCNA	0.18	0.12	lasso	2	0.11	8.5e-09	-9.8	9.9	6.0e-23	-0.02	0.00	1.00	TRUE
6	GTEx	Cells Transformed fibroblasts	CDS2	0.15	0.03	enet	32	0.07	6.6e-06	-9.9	-5.9	3.2e-09	0.02	0.00	0.98	FALSE
7	GTEx	Colon Transverse	LZTS3	0.13	0.06	lasso	2	0.09	6.4e-05	-6.3	-5.6	2.1e-08	0.05	0.47	0.06	FALSE
8	GTEx	Esophagus Muscularis	C20orf194	0.19	0.10	enet	18	0.13	3.8e-08	-5.1	8.1	6.7e-16	-0.04	0.43	0.35	FALSE
9	GTEx	Muscle Skeletal	C20orf194	0.10	0.08	lasso	3	0.06	1.4e-06	7.0	-7.0	3.5e-12	-0.02	0.09	0.91	FALSE
10	GTEx	Nerve Tibial	C20orf194	0.14	0.10	lasso	6	0.08	4.6e-06	8.0	8.0	1.5e-15	0.03	0.01	0.99	FALSE
11	GTEx	Nerve Tibial	PCNA	0.20	0.12	lasso	5	0.11	6.4e-08	-9.8	9.8	1.1e-22	-0.02	0.01	0.99	FALSE
12	GTEx	Nerve Tibial	UBOX5	0.14	0.05	lasso	5	0.08	4.2e-06	-4.6	5.5	4.6e-08	-0.01	0.89	0.00	TRUE
13	GTEx	Stomach	ITPA	0.18	0.04	enet	32	0.03	9.1e-03	4.0	-5.6	2.2e-08	-0.02	0.03	0.95	FALSE
14	GTEx	Thyroid	RNF24	0.22	0.00	enet	45	0.02	5.9e-03	-3.9	-5.9	4.1e-09	-0.10	0.35	0.07	TRUE
15	GTEx	Whole Blood	C20orf194	0.06	0.03	lasso	2	0.01	4.5e-02	6.9	-6.2	4.9e-10	0.00	0.15	0.80	FALSE
16	NTR	Blood	ITPA	0.03	0.01	blup	431	0.02	1.6e-06	3.9	-5.8	6.1e-09	0.01	0.16	0.83	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	C20orf194	0.13	0.04	enet	14	0.11	9.8e-14	-2.3	6.8	1.3e-11	0.07	0.61	0.39	FALSE
18	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ITPA	0.19	0.00	blup	55	0.08	1.0e-04	4.4	-5.9	4.1e-09	0.00	0.05	0.63	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	C20orf194	0.06	0.00	blup	97	0.03	7.5e-03	5.6	7.9	2.5e-15	-0.02	0.06	0.67	FALSE
20	The Cancer Genome Atlas	Esophageal Carcinoma	ITPA	0.33	0.16	enet	6	0.23	5.2e-08	4.0	-5.3	1.4e-07	0.06	0.88	0.07	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	ITPA	0.19	-0.01	blup	54	0.07	3.3e-03	-4.2	-5.4	5.4e-08	0.06	0.02	0.18	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C20orf194	0.05	0.04	blup	98	0.03	6.3e-04	7.3	8.2	3.0e-16	0.00	0.16	0.61	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C20orf194	0.08	0.01	blup	98	0.04	2.8e-03	4.8	6.9	6.3e-12	-0.03	0.03	0.55	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ITPA	0.27	0.18	blup	54	0.23	2.6e-13	4.0	-5.2	2.6e-07	0.03	0.99	0.00	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	ITPA	0.30	0.26	blup	53	0.32	8.7e-38	4.0	-5.7	1.6e-08	0.03	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	PCNA	0.03	0.00	blup	35	0.01	3.1e-02	-9.6	8.8	1.0e-18	-0.04	0.01	0.61	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ITPA	0.41	0.15	blup	53	0.22	1.4e-09	4.0	-5.4	7.4e-08	-0.01	0.50	0.50	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	ITPA	0.32	0.24	enet	15	0.30	1.1e-31	4.0	-5.2	2.4e-07	0.03	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ITPA	0.31	0.08	blup	54	0.11	8.1e-04	4.0	-6.7	1.8e-11	0.01	0.02	0.23	FALSE
30	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SMOX	0.31	0.05	lasso	5	0.07	1.3e-03	-3.6	-5.6	2.8e-08	-0.30	0.05	0.05	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	C20orf194	0.23	0.01	enet	18	0.08	3.1e-08	7.3	5.8	6.5e-09	0.03	0.39	0.38	FALSE