Hub : Genes

RNF24

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1990	0.0390	1.2e-11	0.142	0.101	0.125	0.119	0.132	6.9e-17	2.7e-12	6.3e-15	2.9e-14	1.0e-15
2	GTEx	Adipose Subcutaneous	0.1320	0.0450	2.6e-03	0.074	NA	0.024	NA	0.044	1.1e-06	NA	4.3e-03	NA	1.5e-04
3	GTEx	Brain Caudate basal ganglia	0.3230	0.0900	1.1e-03	0.267	NA	0.209	NA	0.260	2.6e-08	NA	1.2e-06	NA	4.2e-08
4	GTEx	Brain Cortex	0.4590	0.1240	1.4e-03	0.000	NA	0.064	NA	0.041	3.2e-01	NA	7.5e-03	NA	2.8e-02
5	GTEx	Cells Transformed fibroblasts	0.3090	0.0580	1.1e-07	0.082	NA	0.181	NA	0.206	1.0e-06	NA	1.6e-13	NA	2.0e-15
6	GTEx	Nerve Tibial	0.1971	0.0532	4.4e-05	0.096	NA	0.112	NA	0.119	2.7e-07	NA	2.5e-08	NA	9.0e-09
7	GTEx	Skin Sun Exposed Lower leg	0.1380	0.0420	4.7e-04	0.083	NA	0.087	NA	0.076	2.0e-07	NA	1.1e-07	NA	7.5e-07
8	GTEx	Thyroid	0.2210	0.0540	3.3e-05	-0.002	NA	0.024	NA	0.007	5.1e-01	NA	5.9e-03	NA	9.4e-02
9	GTEx	Vagina	0.5350	0.1220	3.9e-04	0.003	NA	0.002	NA	-0.013	2.8e-01	NA	2.8e-01	NA	8.9e-01
10	ROSMAP	Brain Pre-frontal Cortex	0.2927	0.0385	0.0e+00	0.273	0.181	0.290	0.276	0.288	4.1e-35	1.1e-22	1.5e-37	1.6e-35	2.3e-37
11	YFS	Blood	0.0996	0.0189	1.5e-15	0.045	0.056	0.072	0.074	0.066	1.6e-14	8.0e-18	1.7e-22	3.6e-23	1.1e-20
12	TCGA	Lung Squamous Cell Carcinoma	0.0480	0.0290	3.9e-03	0.005	0.018	0.012	NA	0.011	8.0e-02	3.7e-03	1.5e-02	NA	1.9e-02
13	TCGA	Thyroid Carcinoma	0.0370	0.0190	2.3e-03	0.020	0.020	0.009	NA	0.021	4.2e-03	4.4e-03	4.1e-02	NA	3.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.9	1.4	4.5	2.1	1.7	1.1	1.0	0.4	1.3	0.8	-0.1	-1.4	-0.8	-1.7	0.5	0.1
Bipolar Disorder or Schizophrenia	1.8	4.5	13.7	3.5	2.5	2.6	2.4	0.8	2.1	1.2	-0.3	-0.6	-2.3	-3.7	0.6	-0.4
Depressed Affect (Nagel 2018)	0.5	1.0	2.7	0.1	0.6	1.5	-0.5	1.5	1.0	1.6	-0.4	0.0	-1.2	-0.6	1.2	0.7
Depression (Nagel 2018)	1.5	2.2	5.5	1.4	2.4	1.4	-0.2	2.1	2.1	1.9	0.9	0.2	-1.2	-1.0	1.1	1.6
Intelligence (Savage-Jansen 2018)	1.8	5.6	13.0	-3.5	-1.3	-3.6	-2.0	-0.6	-2.1	-2.4	-2.5	-2.8	3.0	2.5	-0.7	1.0
Neuroticism (Nagel 2018)	0.7	1.7	4.8	0.3	1.2	2.2	-0.5	1.3	1.5	1.9	0.9	0.6	-1.8	-0.2	1.7	0.7
Schizophrenia (2018)	1.7	3.4	11.2	2.8	1.9	2.4	2.3	0.7	1.7	0.9	-0.3	0.7	-2.4	-3.3	0.3	-0.6
Schizophrenia vs Biploar Disorder	0.5	0.7	2.3	0.6	-0.1	1.3	0.8	-0.3	0.0	0.2	-1.1	1.5	-1.0	-0.3	0.3	-1.2
Worry (Nagel 2018)	0.7	1.5	5.9	0.6	0.8	2.4	-0.4	1.7	1.0	1.5	0.8	-0.4	-2.0	0.0	0.9	-0.3
Alzheimer’s Disease (in mother)	0.2	0.3	1.9	-0.0	0.3	-0.5	-0.5	-0.0	0.0	-0.1	-0.5	-1.4	0.5	-0.3	-0.2	0.4
Alzheimer’s Disease (in father)	0.6	0.6	2.9	0.9	0.9	0.5	1.7	0.1	0.7	-0.1	-0.7	-0.0	-0.1	0.2	1.5	0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	0.6	0.6	0.3	1.2	-0.0	0.6	0.3	-0.4	-0.6	-0.1	0.3	1.1	0.4
Crohns Disease (2017)	0.1	0.3	1.4	-0.4	-0.7	0.1	1.2	-0.6	-0.5	0.2	-0.2	0.6	-0.7	-0.1	-0.5	-0.6
Irritable Bowel Disease (IBD)	0.3	0.8	2.9	-1.7	-0.8	-1.3	0.6	-0.3	-0.8	-0.1	-1.0	-0.4	1.2	0.4	-0.8	0.4
Ulcerative Colitis (UC)	0.6	1.1	4.5	-1.7	-0.3	-1.7	0.2	0.6	-0.5	0.2	-1.0	-0.7	2.1	0.2	-0.6	1.0
Major Depression (MDD)	1.2	1.5	6.8	1.0	-0.7	1.2	-0.2	-0.6	-0.8	-0.9	-0.5	-1.1	-1.8	-1.0	-1.2	-2.6
Reaction Time	1.1	2.1	5.3	-1.5	-1.4	-1.6	0.5	-1.6	-1.9	-2.3	-1.6	-1.2	1.4	0.7	-0.8	-1.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.4	-1.0	0.2	-1.4	-0.6	0.3	-0.2	-0.1	-0.6	-1.8	0.7	1.4	-0.3	1.2
Breast Cancer	0.4	0.9	3.1	0.3	-0.8	0.2	1.4	0.2	-0.8	-0.3	-0.3	1.1	-0.8	1.8	-1.3	-1.2
Ovarian Cancer	1.1	1.5	4.4	-1.4	-0.1	-1.7	-0.5	-2.1	-0.5	-0.7	-0.9	1.0	1.8	0.3	1.6	1.0
Prostate Cancer	0.3	0.5	1.6	1.3	0.9	0.3	1.2	0.5	0.8	0.4	-0.7	0.1	-0.5	0.1	0.1	0.5
Age at First Birth	0.6	0.9	3.8	-0.3	0.2	-0.7	-0.8	-0.9	0.1	-0.4	1.9	-1.4	1.1	0.7	1.0	0.7
Bipolar Disorder (2011)	0.7	0.7	3.0	-0.8	-0.6	-0.5	-0.7	-0.7	-0.6	0.2	-1.6	-1.7	0.6	-0.1	-0.3	-0.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	0.6	0.3	0.5	-0.3	-0.7	0.7	-0.0	1.0	-1.1	0.1	-0.7	1.1	0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.3	-0.1	-0.9	0.1	-1.0	-0.1	-0.8	-0.4	-0.3	0.4	-0.6	-0.7	-1.0	-1.2
Crohns Disease (2012)	0.1	0.2	0.6	-0.2	-0.3	0.1	0.3	-0.8	-0.1	0.8	-0.6	-0.6	-0.1	-0.7	0.2	-0.2
Mean Putamen Volume	0.6	0.7	3.8	1.0	0.7	-0.4	0.7	-1.1	0.4	-0.3	2.0	1.1	0.7	-0.2	0.2	0.5
Fasting Glucose	1.0	1.2	3.1	0.2	1.0	0.9	1.3	1.7	1.1	1.2	1.4	-0.8	-0.8	-1.8	-0.1	0.9
HbA1C	0.7	0.8	2.9	0.7	0.8	0.8	1.1	0.8	1.0	1.7	0.8	-0.1	-1.1	-0.5	0.8	0.6
HDL Cholesterol	0.7	1.2	4.2	-0.5	-0.8	-0.8	-0.2	-0.9	-1.2	-1.6	-2.0	1.5	0.8	0.3	-0.3	-1.0
LDL Cholesterol	1.2	1.9	5.0	1.5	2.0	0.7	0.4	2.2	2.1	1.0	1.0	1.5	-0.6	0.4	0.6	1.8
Lupus	0.8	1.2	5.2	-0.7	-1.0	-0.7	0.4	-2.3	-1.3	-1.8	0.3	0.7	1.0	0.8	0.3	-1.0
Neuroticism (2016)	0.3	0.4	1.8	-0.1	0.4	0.1	-0.6	0.0	0.5	0.6	-1.0	0.8	0.1	-0.3	1.3	0.4
Primary Biliary Cirrhosis	1.0	1.4	10.7	1.6	1.2	0.4	0.4	-0.1	1.1	0.1	1.2	-3.3	-0.3	-0.5	0.4	0.2
Rheumatoid Arthritis	0.4	0.5	3.6	0.0	0.1	-0.1	-0.3	0.7	-0.0	-0.7	1.9	-0.8	-0.1	-1.0	-0.7	0.1
Schizophrenia (2014)	1.4	3.0	11.6	2.4	1.8	2.4	1.4	0.2	1.7	1.7	-0.6	0.1	-1.7	-3.4	0.9	-0.4
Triglycerides	0.3	0.5	1.1	-1.0	-1.1	-0.2	-0.6	-0.3	-0.8	-0.9	-0.3	0.7	0.2	1.0	-0.4	-0.5
Type 2 Diabetes (T2D) (2012)	0.8	1.0	4.2	-2.1	-1.2	-0.6	-1.3	0.1	-0.8	-0.4	-0.1	0.8	0.9	1.2	1.0	0.1
Ulcerative Colitis	0.3	0.4	1.9	-0.9	-0.4	-0.0	-0.2	-0.0	-0.1	0.2	-0.7	-1.4	1.0	-0.3	-0.5	0.1
Blood Eosinophil Count	0.3	1.9	5.8	-2.1	0.5	-1.4	-1.6	0.6	0.5	1.8	0.0	1.4	1.3	1.0	1.4	2.4
Blood Platelet Count	0.3	3.1	13.6	1.0	-1.0	3.0	-0.7	2.1	0.0	1.5	1.4	0.2	-3.7	-0.4	-1.9	-1.8
Blood Red Count	0.1	1.0	5.4	-1.2	-1.0	-1.0	0.8	-0.7	-1.2	-0.8	0.3	-0.5	0.9	2.3	-0.2	-0.5
Blood White Count	0.3	2.1	12.2	-0.3	-0.2	0.5	-1.6	1.8	0.1	0.7	3.5	-0.1	-0.7	2.8	-0.4	0.1
Heel T-Score	0.9	7.2	21.3	4.0	1.7	4.6	4.3	0.7	2.0	1.6	0.5	1.9	-4.1	-1.6	-0.4	-2.0
BMI	0.8	4.4	13.0	1.2	2.5	0.3	-0.0	1.5	2.7	3.6	2.6	-0.6	0.0	-1.9	2.1	3.3
Height	0.5	9.2	34.6	-3.5	-3.2	-1.7	-0.3	-2.5	-3.2	-2.4	-5.9	1.1	3.2	4.5	-1.4	-1.8
Waist Hip Ratio (WHR)	1.2	5.3	16.9	-4.1	-3.3	-1.8	-2.1	0.4	-2.7	-0.8	-1.9	1.5	1.9	3.7	-1.5	-0.7
Systolic Blood Pressure	0.2	1.2	6.5	1.3	-0.7	1.4	1.2	-0.6	-0.8	-0.2	-0.0	0.2	-1.0	-1.1	-0.7	-2.5
Smoking Status	0.2	0.4	1.3	0.9	0.5	1.1	1.1	-0.0	0.6	-0.0	-0.2	0.9	-0.6	-0.7	0.4	0.0
Allergy or Eczema	0.4	1.2	4.3	-0.9	-0.4	-0.7	1.2	-1.4	-0.2	-0.6	-0.9	2.1	1.6	1.4	0.7	0.5
Cardiovascular Disease	0.7	2.3	6.3	2.5	1.7	2.1	1.5	0.1	1.7	1.1	1.1	0.5	-1.5	-2.1	1.4	0.0
Hypothyroidism (self reported)	1.0	2.4	11.0	0.5	1.5	0.2	-0.9	1.5	1.4	1.3	3.3	-2.4	-0.3	-0.7	1.2	1.7
Respiratory disease	1.3	2.8	7.7	-1.2	-2.1	0.1	-0.8	-0.2	-2.1	-1.2	-2.8	0.6	-0.7	-1.7	-2.6	-2.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.3	0.6	0.7	0.8	-0.9	-0.1	1.0	1.5	1.1	-0.2	-0.1	-0.1	1.4	0.5
Lung FEV1/FVC ratio	0.4	2.1	13.3	-2.1	-1.1	-0.3	-1.1	-0.6	-1.2	-1.0	-3.7	1.7	-0.0	0.8	-0.8	-0.7
Lung FVC	0.2	0.8	3.2	0.6	0.9	0.3	1.0	0.6	-0.1	-1.8	0.5	-1.4	-1.0	-1.2	-0.3	-0.7
Neuroticism	0.1	0.3	1.3	-0.4	0.1	1.2	-0.8	0.7	0.2	0.4	-0.3	-0.1	-1.1	0.4	0.3	-0.2
Chronotype (morning person)	1.2	2.8	6.3	-1.1	0.7	-2.0	0.5	-1.4	0.1	0.3	-2.2	2.5	2.2	2.4	1.9	2.0
Hair Pigment	0.1	3.3	13.0	-3.6	-1.9	-2.6	-2.2	0.1	-1.8	-0.4	0.1	-0.0	2.7	1.8	-0.3	0.8
Tanning	0.1	1.1	3.7	0.6	1.3	-0.1	-0.6	0.2	1.1	1.1	0.1	-0.8	0.5	-1.5	1.9	1.5
Hand grip strength (left)	1.8	4.8	10.9	-1.4	-2.4	-2.0	-0.7	-2.8	-3.0	-3.3	-1.9	-0.2	1.8	2.7	-1.9	-2.0
Number of treatments/medications taken	0.5	0.8	4.0	0.8	0.6	0.9	0.4	0.7	1.1	2.0	-0.8	0.1	-0.4	-1.3	0.4	0.6
Average weekly spirits intake	1.1	1.4	4.0	1.1	0.3	2.0	1.2	1.1	0.5	-0.0	0.9	-0.6	-1.9	-1.9	-0.9	-0.7
Sensitivity / hurt feelings	1.0	1.7	4.5	0.4	1.4	1.4	0.2	2.1	1.6	0.9	0.9	1.5	-1.9	-0.9	1.1	1.2
Frequency of depressed mood in last 2 weeks	2.2	3.0	6.6	1.0	2.4	1.5	0.3	2.6	2.2	2.6	0.4	-0.4	-1.4	-2.0	1.7	1.8
Hearing difficulty/problems: Yes	0.9	1.4	5.1	1.7	1.2	0.7	1.3	0.5	1.5	1.7	0.2	-0.5	-0.4	-2.2	0.7	0.8
Relative age of first facial hair	0.7	1.3	4.9	-2.0	-1.9	-0.6	-0.6	-0.1	-1.4	-0.6	-0.5	1.1	-0.1	2.2	-0.4	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.7	-0.1	1.0	-0.0	0.5	0.1	0.9	0.8	0.3	-0.7	0.7	-1.3	0.8	1.3
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.6	0.5	1.4	0.1	1.1	0.6	1.6	1.9	1.2	0.4	0.3	-1.3	1.2	1.8
Ever had hysterectomy (womb removed)	0.5	0.5	1.8	-1.3	-0.9	-0.3	0.3	0.6	-0.6	0.2	-0.4	0.9	0.2	-1.3	-0.6	-0.2
Systolic blood pressure, automated reading	0.3	0.8	3.3	1.3	0.7	0.8	-0.2	0.2	0.3	0.5	1.8	-1.3	-0.0	-1.5	0.4	-0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	2.9	0.2	-0.2	-0.1	-1.7	-0.4	0.0	0.7	0.7	-0.5	0.4	0.0	0.3	0.1
Angina	1.6	2.2	7.2	2.2	1.7	1.4	2.7	1.9	1.7	1.4	-0.0	-0.2	-1.2	-1.0	-0.3	0.3
Medication for hormone replacement therapy	2.4	2.7	5.8	1.9	1.5	2.4	-0.4	0.7	2.1	1.7	1.6	-0.4	-1.6	-2.2	2.1	0.8
Vitamin and mineral supplements	0.8	1.0	3.3	1.0	-0.2	1.6	-0.3	0.2	0.1	0.8	1.8	-1.0	-1.4	-0.2	-1.2	-1.3
Supplements: Zinc	1.4	1.5	4.2	-1.1	0.6	-0.8	-0.9	-0.2	0.7	0.6	-0.7	1.5	1.8	1.5	1.7	2.0
Medication: Co-codamol	0.3	0.4	0.8	0.8	0.7	0.2	0.1	-0.6	0.7	0.9	0.0	-0.2	0.3	-0.8	0.9	0.5
Medication: Metformin	0.4	0.6	2.4	0.7	0.4	1.5	-0.4	0.6	0.5	0.5	0.8	-1.3	-1.0	-0.2	0.4	-0.7
Diabetes (father)	0.7	0.9	2.0	1.0	1.2	1.0	0.6	0.2	1.4	1.1	0.8	-0.9	-0.3	0.2	1.3	1.0
Diabetes (mother)	0.9	1.1	5.6	-0.1	-0.5	1.2	-0.3	0.4	-0.5	-0.0	2.4	1.8	-1.1	-0.9	-0.1	-1.1
Severe depression (siblings)	0.1	0.2	0.7	-0.2	-0.2	-0.4	-0.2	0.3	-0.4	-0.8	-0.3	0.3	0.6	-0.1	-0.5	-0.4
Pack years adult smoking proportion	0.5	0.7	1.4	1.1	0.3	1.1	0.3	0.4	0.7	0.8	0.9	-1.2	-1.1	-1.2	0.4	-0.1
Impedance of leg (right)	0.6	2.8	10.0	-0.2	-1.3	1.8	0.5	0.4	-0.7	-0.4	-1.4	3.2	-2.1	3.0	-0.9	-1.9
Leg fat-free mass (left)	0.2	1.3	5.0	-1.5	-0.6	-1.4	-0.8	-1.5	-0.9	-0.4	-1.2	-1.3	2.2	-0.5	0.1	0.5
Trunk fat percentage	0.3	1.1	4.5	0.8	1.1	1.2	0.3	1.4	1.3	2.1	0.6	1.0	-0.8	-0.7	0.3	0.8
Hand grip strength (right)	1.9	5.2	11.6	-2.3	-2.2	-2.8	-1.0	-2.4	-2.9	-3.4	-2.0	0.2	2.4	2.9	-1.7	-1.2
Townsend deprivation index at recruitment	0.4	0.6	1.7	-0.4	-1.3	0.3	-0.5	-0.5	-0.8	0.3	-1.0	0.4	-0.8	-0.8	-1.0	-1.3
Current tobacco smoking	0.5	0.9	3.8	0.9	0.3	1.9	0.3	1.3	0.6	1.0	0.1	-0.3	-1.7	-0.5	0.0	-0.6
Average weekly fortified wine intake	2.8	3.3	7.8	-1.6	-2.4	-0.8	-0.8	-1.3	-2.7	-2.6	-1.4	0.0	0.1	0.6	-2.7	-2.8
Maternal smoking around birth	0.6	0.9	6.2	-0.1	0.6	-0.6	-0.9	0.7	0.5	0.7	-1.1	2.5	0.3	-0.1	0.5	1.1
Fed-up feelings	1.2	2.3	7.2	0.8	1.3	1.8	-0.2	1.8	1.6	2.7	1.2	0.0	-2.0	-1.3	1.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	4.3	0.4	1.3	0.7	0.0	1.9	1.1	2.1	0.9	0.1	-1.0	-0.8	0.6	1.2
Relative age voice broke	0.2	0.3	1.6	-1.2	-0.6	-0.2	-0.3	0.5	-0.4	-0.1	-0.7	0.3	0.0	0.2	0.5	0.3
Taking other prescription medications	0.3	0.5	2.1	0.6	0.2	-0.1	0.8	-0.9	0.1	-0.0	-0.3	-1.3	0.0	-1.5	-0.7	-0.2
Age when periods started (menarche)	0.4	1.0	3.3	-1.1	-1.1	-1.8	-1.1	-0.0	-1.0	-0.3	0.3	-0.1	1.0	1.8	-0.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	-0.9	-1.0	-0.8	-0.3	-0.2	-1.0	-1.0	-0.4	-1.0	0.3	-1.0	-0.8	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	8.9	3.0	1.0	2.4	2.8	-0.2	0.8	-0.1	0.7	0.8	-2.0	-0.0	-0.6	-1.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	5.3	1.2	-0.1	1.0	1.0	-0.6	0.1	-0.2	2.3	-0.2	-1.1	-2.0	-0.6	-1.3
Qualifications: CSEs or equivalent	1.1	1.5	6.0	0.2	0.5	0.9	1.2	0.6	1.2	2.4	0.9	1.8	-1.4	-1.1	1.1	1.0
Serious illness, injury or assault to yourself	0.2	0.3	1.2	-0.0	-0.3	0.3	0.9	-0.2	0.1	0.2	-0.7	-1.1	-0.6	-0.4	-0.4	0.0
High blood pressure	0.7	1.9	6.7	1.7	0.6	2.0	2.1	0.3	0.6	0.3	1.0	0.2	-1.8	-2.6	0.0	-1.1
Hayfever, allergic rhinitis or eczema	0.8	1.7	8.9	-1.3	-0.9	-0.9	0.8	-1.1	-0.9	-0.8	-1.5	3.0	1.1	1.7	0.2	-0.0
Multivitamins +/- minerals	0.5	0.6	2.7	-0.5	0.7	-0.5	0.2	0.4	0.6	0.5	-0.9	0.4	0.4	0.5	1.6	1.5
Stomach or abdominal pain in last month	1.0	1.2	2.8	1.2	1.0	1.1	1.0	0.1	1.5	1.7	1.1	0.3	-0.6	-1.6	0.6	1.0
Supplements: Glucosamine	1.0	1.3	5.8	0.0	1.4	-1.2	0.0	0.3	1.2	0.4	1.3	-0.3	1.3	-0.6	1.3	2.4
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	4.5	0.7	1.1	1.5	1.0	-0.3	1.4	1.6	2.1	-0.8	-0.6	0.1	1.2	1.0
Medication: Atenolol	2.2	2.7	6.5	2.4	1.5	1.6	2.3	-0.9	1.8	1.6	2.5	1.0	-1.2	-1.6	1.1	0.3
Medication: Levothyroxine sodium	1.8	3.0	9.0	1.3	1.9	1.4	1.5	1.7	1.9	2.2	3.0	-0.7	-1.0	-1.6	1.6	1.5
Sitting height	0.5	3.5	11.0	-0.6	-0.8	-0.8	-0.2	-3.3	-1.8	-2.9	-3.2	0.8	1.6	2.2	0.0	-1.7
Chronic bronchitis/emphysema (father)	0.4	0.4	1.9	0.4	0.4	0.1	1.4	-0.6	0.0	-0.9	1.1	-0.1	0.5	-0.4	0.9	-0.2
High blood pressure (mother)	0.4	0.5	1.9	0.1	0.7	-0.3	-0.5	-0.4	0.8	1.4	-0.7	0.3	0.3	-0.1	0.9	1.2
Body mass index (BMI)	0.9	3.7	7.4	1.7	2.6	0.6	-0.0	1.7	2.4	2.7	2.5	-0.9	-0.1	-2.7	1.4	2.6
Impedance of leg (left)	0.7	3.3	14.2	-0.2	-1.1	1.7	0.7	0.1	-0.7	-0.5	-1.9	3.8	-2.0	3.3	-1.0	-1.9
Leg predicted mass (left)	0.2	1.3	4.9	-1.5	-0.6	-1.4	-0.9	-1.5	-0.9	-0.4	-1.3	-1.3	2.2	-0.5	0.1	0.4
Trunk fat mass	0.1	0.6	2.9	0.6	1.0	0.9	0.3	0.8	1.0	1.7	0.3	0.5	-0.3	-0.6	0.4	0.8
Waist circumference	0.2	0.7	2.3	-0.3	0.5	0.1	-0.9	1.4	0.6	1.5	1.1	-0.4	0.5	0.1	0.1	1.2
Number of incorrect matches in round	0.9	1.5	3.4	-1.0	-1.2	-1.8	-0.5	-1.6	-1.6	-1.5	-1.2	1.0	1.2	-0.1	-1.0	-1.0
Past tobacco smoking	0.9	1.7	6.3	-2.2	-1.1	-1.3	-2.5	0.3	-1.1	-0.1	-2.3	0.6	0.9	0.9	0.1	-0.0
Alcohol usually taken with meals	1.1	1.7	7.4	-0.1	1.0	-0.1	-0.3	-0.4	1.4	0.7	0.3	0.5	0.7	2.6	2.7	1.9
Nervous feelings	1.1	2.0	8.5	-0.3	-1.5	1.5	-0.5	0.2	-1.4	-0.2	-1.2	0.8	-1.7	-0.2	-2.3	-2.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	5.3	0.4	1.0	0.5	-1.4	0.9	0.5	0.7	-0.0	-0.4	-0.9	-2.3	0.5	0.4
Hearing difficulty/problems with background noise	3.5	5.6	12.7	3.6	2.7	2.4	2.9	1.2	2.9	3.0	1.1	-0.9	-2.1	-3.2	1.4	0.8
Hair/balding pattern: Pattern 2	0.8	1.0	3.0	0.5	0.7	1.1	0.9	1.4	0.7	1.2	1.7	0.6	-0.6	-1.5	0.7	0.5
Had menopause	0.8	1.0	5.5	-0.4	-0.5	-0.3	0.4	0.4	0.0	0.9	2.3	-2.3	-0.1	0.5	-0.2	0.3
Had other major operations	0.7	0.8	3.4	0.1	-0.2	-1.1	0.6	-1.8	-0.5	-1.3	-1.0	-1.0	1.2	-0.4	-0.1	-0.3
Forced vital capacity (FVC)	0.7	2.7	6.7	-2.0	-1.6	-1.3	-0.9	-1.5	-2.1	-2.6	-2.5	0.5	1.0	1.5	-0.7	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	8.8	3.0	1.3	1.9	2.0	-0.1	0.9	-0.4	-0.1	1.3	-1.5	0.4	-0.5	-1.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.0	0.1	-0.1	1.0	-0.2	-0.3	0.1	-0.7	0.5	-0.4	-0.8	-0.8	0.4	-0.6
Qualifications: None of the above	0.3	0.6	1.5	1.2	0.4	0.4	-0.1	-1.1	0.6	1.1	1.0	1.0	0.3	0.3	0.6	-0.1
Financial difficulties in last 2 years	1.2	1.6	5.0	-1.1	-0.6	-2.0	-1.3	-0.5	-0.5	0.0	-2.2	-1.6	1.9	-1.0	-0.2	0.9
Mouth/teeth dental problems	0.8	1.2	3.2	-0.9	0.4	-0.9	-1.5	-0.3	0.6	0.8	1.3	0.4	1.6	-0.3	1.4	1.8
Heart attack	0.8	1.1	4.2	0.5	-0.3	1.5	2.1	-0.7	0.1	1.0	-0.0	1.4	-1.4	-0.7	-0.4	-1.0
Allergy	0.9	2.0	8.3	1.6	1.3	1.1	-0.2	0.7	1.4	1.0	2.5	-2.9	-0.9	-0.8	0.5	0.6
Pain all over the body in last month	0.4	0.4	2.0	0.4	0.3	0.9	-0.2	0.3	0.7	0.9	-0.7	1.4	-0.2	-0.6	0.4	0.0
Diabetes (self-reported)	0.5	0.7	2.4	0.8	1.0	1.3	-0.3	0.6	1.2	1.0	0.3	-0.6	-0.7	-0.4	1.6	0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	3.7	-0.2	-0.6	0.2	0.4	-1.0	-0.3	-0.6	-0.4	1.9	0.6	0.6	-0.2	-0.4
Medication: Ramipril	1.4	1.9	5.3	2.1	1.2	2.3	1.9	0.1	1.5	1.1	1.3	-0.1	-1.8	-0.8	0.8	-0.1
Medication: Simvastatin	0.5	0.8	2.9	1.1	0.3	1.7	0.1	-0.9	0.6	1.1	-0.3	0.9	-1.1	0.1	1.0	-0.5
Fluid intelligence score	0.3	0.6	2.4	0.0	0.5	-0.0	-1.3	0.8	0.0	-0.6	-1.0	-1.5	-0.9	-0.2	-1.0	0.3
Illnesses of siblings	0.5	0.7	2.4	-0.8	-0.9	-1.3	-0.2	-0.3	-0.8	-0.9	-1.0	-0.0	1.2	1.5	-0.4	0.0
Neuroticism score	0.3	0.6	1.7	-0.6	0.3	0.9	-1.0	1.3	0.4	1.1	-0.8	0.6	-1.1	-0.6	0.3	0.4
Weight	0.1	0.5	1.7	-0.0	0.8	-0.1	-0.3	0.2	0.7	1.2	0.0	-0.3	0.9	-0.6	0.6	1.3
Impedance of arm (right)	0.7	3.3	7.1	-2.3	-2.7	-0.5	-0.2	-0.7	-2.3	-2.1	-2.6	1.4	0.2	2.1	-1.4	-2.0
Arm fat percentage (right)	0.6	2.3	5.5	1.0	1.8	0.7	0.0	1.9	1.9	2.1	1.8	-0.8	-0.3	-2.3	0.9	2.0
Trunk fat-free mass	0.3	1.7	5.3	-1.5	-0.8	-1.6	-0.6	-1.9	-1.3	-1.1	-1.4	-1.3	2.3	0.6	-0.3	0.1
Hip circumference	0.2	0.9	3.2	0.4	1.5	-0.1	-0.4	0.5	1.2	1.0	0.7	-0.8	0.9	-1.0	0.7	1.8
Time employed in main current job	1.0	1.1	4.8	0.1	-0.3	0.9	0.9	0.0	0.2	1.1	2.2	2.1	-1.2	0.3	0.8	-0.5
Alcohol intake versus 10 years previously	0.8	1.2	3.8	0.4	-1.2	-0.2	0.4	-1.4	-1.4	-1.2	-0.7	-0.5	-0.2	0.6	-1.7	-1.9
Father’s age at death	1.6	2.1	6.6	-1.1	-1.5	-1.0	-1.5	-1.8	-1.8	-2.6	0.7	-1.9	0.6	0.7	-1.1	-1.3
Worrier / anxious feelings	0.3	0.6	1.9	-1.2	-0.2	1.0	-0.1	0.9	0.2	1.1	0.5	0.1	-1.4	0.5	1.0	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.0	0.0	0.7	0.2	-0.7	-0.3	0.4	0.8	0.6	-0.8	0.2	-1.7	1.1	0.5
Falls in the last year	0.7	1.0	3.3	-0.7	-0.9	-0.8	0.3	-1.8	-0.7	-0.6	-1.8	-0.5	1.4	-0.4	0.7	-0.2
Hair/balding pattern: Pattern 3	0.3	0.4	1.5	-0.4	0.4	-0.8	-1.2	0.7	0.1	-0.5	-1.2	0.0	0.2	0.7	-0.5	0.4
Number of live births	4.1	5.9	12.1	3.5	2.5	2.5	3.4	1.3	2.7	2.8	2.0	-0.3	-3.0	-3.0	0.9	0.8
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	12.8	-3.2	-2.2	-2.3	-1.3	-1.9	-2.8	-3.1	-3.6	0.8	1.7	2.4	-0.8	-1.1
Pulse rate	0.5	0.9	3.4	-1.3	-0.9	-0.5	0.3	0.4	-0.4	0.6	-1.8	1.5	0.7	1.1	-0.5	0.5
Happiness	0.5	0.7	3.0	-0.7	0.7	0.1	0.9	1.7	0.7	0.7	0.6	0.4	-0.2	-0.4	0.6	1.2
Noisy workplace	0.2	0.2	1.1	0.0	-0.4	0.3	1.0	-0.1	-0.0	0.4	-1.1	-0.3	0.0	-0.5	-0.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	6.3	-0.2	1.1	-0.1	-1.1	-0.6	0.9	0.0	1.1	-0.9	0.4	0.4	2.5	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.2	-0.7	-0.6	-0.1	-0.5	0.4	-0.7	-0.7	-0.5	-0.9	-0.2	1.1	-0.5	-0.5
Mouth/teeth dental problems: Dentures	1.1	1.8	6.5	2.5	0.7	1.5	1.9	-0.7	0.3	-0.8	0.3	-0.9	-1.2	-1.6	-1.2	-1.7
Asthma	1.2	2.4	10.0	-1.2	-1.7	-1.1	-0.6	-0.1	-1.8	-1.2	-3.2	0.8	0.0	-1.1	-2.5	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	4.7	-1.2	-0.8	-0.6	-0.1	-0.4	-0.4	0.3	-2.2	1.4	0.8	0.2	-0.5	0.1
Medication: Cholesterol lowering	0.6	0.9	3.7	1.2	0.6	0.5	1.0	-1.9	0.8	1.0	0.0	0.6	0.0	0.5	1.5	0.4
Depression (self-reported)	2.1	2.5	6.2	0.9	1.4	2.5	1.3	1.8	1.6	2.0	1.1	-1.7	-1.5	-1.8	1.0	0.7
Medication: Lansoprazole	1.3	1.5	5.2	0.5	-0.9	1.6	0.8	-0.1	-0.3	0.1	0.9	-1.8	-1.4	-0.5	-2.3	-1.9
Prospective memory result	1.1	1.3	7.2	-1.8	-1.7	-0.1	-0.7	0.1	-1.1	0.8	-0.7	2.7	0.1	0.3	-0.3	-0.7
Lung cancer (father)	1.3	1.5	7.0	-0.7	-1.2	0.5	-0.1	1.5	-0.8	0.8	-0.5	-0.5	-1.1	-2.6	-2.0	-1.1
Illnesses of mother	0.4	0.5	4.0	0.2	-0.4	0.1	0.9	-0.6	-0.5	-2.0	0.1	0.4	0.1	0.1	-0.3	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.7	9.7	-3.1	-2.0	-1.4	-0.8	-0.8	-2.2	-1.6	-2.7	0.2	1.1	1.3	-0.7	-0.7
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	-0.2	0.4	0.5	0.3	0.7	0.7	0.8	0.5	0.5	0.4	0.5	0.7	1.1
Impedance of arm (left)	0.9	4.2	9.1	-2.0	-3.0	0.2	-0.4	-0.4	-2.5	-2.0	-2.8	2.3	-0.5	2.1	-2.0	-3.0
Arm fat mass (right)	0.3	1.2	2.9	0.7	1.4	0.3	-0.1	1.1	1.3	1.7	1.2	-0.6	0.3	-1.5	0.7	1.7
Trunk predicted mass	0.3	1.7	5.5	-1.4	-0.8	-1.6	-0.7	-2.0	-1.3	-1.1	-1.4	-1.2	2.4	0.7	-0.3	0.1
Standing height	1.0	10.1	28.3	-3.7	-3.8	-1.4	-0.7	-3.4	-3.9	-3.2	-5.3	1.2	2.2	4.2	-1.5	-2.9
Length of working week for main job	2.1	2.4	6.5	-2.5	-1.4	-1.9	-2.2	-0.4	-1.4	-0.7	-2.1	0.9	1.7	-1.3	-1.1	0.3
Exposure to tobacco smoke at home	1.4	1.6	4.6	-0.0	1.4	-0.5	0.9	1.3	1.4	2.1	1.1	-0.8	-0.2	-0.7	1.7	2.1
Breastfed as a baby	1.3	1.7	3.5	-1.3	-1.1	-1.3	-1.4	-1.1	-1.3	-1.7	-1.0	-1.9	1.5	1.6	0.5	-0.4
Tense / ‘highly strung’	1.1	1.9	4.9	0.5	1.8	0.8	-0.3	2.2	1.6	2.0	-0.4	0.0	-0.7	-2.0	1.1	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.4	0.3	1.1	0.3	0.8	0.4	0.4	-1.0	-1.4	-0.6	-0.3	-2.1	-0.4	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.5	0.0	-0.7	0.1	1.0	-0.9	-0.8	-0.3	-0.9	0.3	-0.4	1.0	-0.2	-1.2
Birth weight of first child	0.2	0.4	0.6	0.8	0.7	0.5	-0.7	0.8	0.5	0.2	0.6	-0.8	-0.5	-0.1	-0.7	-0.3
Peak expiratory flow (PEF)	3.1	7.1	20.3	-2.4	-1.6	-3.4	-1.9	-2.1	-2.5	-3.0	-4.5	2.2	2.8	3.9	-0.6	-0.5
Pulse wave reflection index	0.1	0.2	1.0	-1.0	-0.5	0.2	0.1	0.0	-0.4	0.1	-0.1	0.3	0.3	0.5	0.5	-0.2
Ever highly irritable/argumentative for 2 days	1.5	1.8	6.4	1.0	1.3	1.3	0.1	1.2	1.6	1.5	0.9	-2.5	-1.0	-1.6	1.1	0.7
Loud music exposure frequency	0.9	1.0	4.4	-0.9	-1.0	-0.9	-0.5	-0.0	-1.1	-0.9	0.1	-2.1	0.9	1.1	-0.9	-0.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.5	-0.3	1.1	-1.8	-1.5	-2.1	0.2	-1.6	0.3	-1.4	2.3	1.1	2.4	1.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.6	-0.5	-1.3	-0.2	0.2	0.9	-1.2	-0.9	-1.1	0.5	-1.1	1.0	-1.6	-1.0
Blood clot in the leg (DVT)	0.2	0.3	1.7	-1.0	-0.5	-0.4	-0.2	0.1	-0.4	0.3	0.2	-0.0	0.7	1.3	-0.1	0.1
Medication: Paracetamol	0.4	0.6	2.8	-1.7	-1.5	0.1	-0.0	-0.2	-0.7	0.5	-0.8	-0.1	0.2	-1.1	-0.9	-0.4
Headache pain in last month	0.4	0.7	3.5	-0.0	0.4	-0.9	0.3	-0.5	0.3	0.2	-1.4	0.7	0.9	-1.9	0.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	4.6	-1.5	-0.4	-1.0	-2.2	1.6	-0.6	-0.8	0.4	0.1	0.9	0.2	-0.4	0.5
Glaucoma (self-reported)	0.4	0.4	3.1	0.0	-0.4	-0.3	-0.2	-1.8	-0.2	-0.1	0.2	-0.6	0.4	0.8	0.8	-0.1
Gout (self-reported)	0.5	0.6	2.9	-0.2	0.5	-0.5	0.7	-1.0	0.2	-0.3	-0.4	-1.7	0.8	-0.5	1.4	0.5
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	12.4	0.5	1.6	0.5	0.9	2.1	1.6	1.8	3.5	-0.9	-0.6	-1.0	1.0	1.9
Medication: Amlodipine	0.7	1.0	3.9	1.2	-0.6	1.3	0.9	-0.2	-0.4	-0.5	0.1	-0.5	-1.5	-0.7	-1.3	-2.0
Medication: Ventolin 100micrograms inhaler	3.0	3.9	10.2	-1.4	-2.2	-2.0	-0.4	-0.3	-2.6	-3.2	-3.1	0.6	1.1	0.9	-2.8	-1.6
Birth weight	0.1	0.2	0.8	-0.6	0.3	0.0	-0.3	-0.6	0.4	0.3	-0.4	-0.1	0.3	0.9	0.6	0.8
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.4	-0.4	0.2	-0.1	-0.6	0.4	0.1	0.5	-1.2	0.8	-0.3	-0.4	-0.2	0.6
High blood pressure (siblings)	0.5	0.7	2.1	0.3	0.7	1.3	0.5	1.4	0.7	1.1	0.4	0.4	-1.4	-0.7	0.1	0.1
Forced vital capacity (FVC), Best measure	0.3	1.1	4.5	-2.0	-1.4	-0.4	-0.1	-0.4	-1.4	-0.9	-2.1	-0.0	0.5	0.7	-0.5	-0.6
Body fat percentage	0.5	1.9	5.5	1.3	1.6	1.6	0.5	1.8	1.8	2.3	1.3	0.6	-1.2	-1.2	0.5	1.1
Leg fat percentage (right)	1.5	5.6	11.6	2.5	2.9	2.5	0.9	2.8	3.1	3.4	2.9	0.3	-2.1	-1.7	1.6	2.0
Arm fat-free mass (right)	0.1	0.6	2.8	-0.8	-0.3	-0.8	-0.5	-1.6	-0.6	-0.0	-0.8	-0.4	1.7	0.5	0.1	0.3
Exposure to tobacco smoke outside home	0.7	1.0	3.5	0.6	0.4	0.2	1.9	1.1	0.4	1.1	-0.7	0.8	-1.3	-1.0	-1.5	-0.1
Comparative body size at age 10	0.3	0.9	2.6	0.0	0.5	-1.0	-0.7	-0.2	0.6	0.2	1.4	-0.0	1.0	1.2	1.6	1.4
Number of full brothers	0.3	0.4	1.3	0.8	1.2	-0.3	0.5	0.3	0.6	0.2	-0.2	1.0	0.3	-0.7	-0.3	0.8
Worry too long after embarrassment	0.3	0.5	2.0	-1.3	-0.5	0.6	-0.8	-0.3	-0.4	0.3	-1.4	1.1	-0.4	0.1	0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.6	0.0	0.1	2.0	1.8	2.0	0.4	0.3	-0.5	0.4	-2.0	-2.4	-0.9	-0.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	-0.3	-0.5	-0.2	-0.9	-0.3	-0.5	0.2	-0.9	-0.5	-0.8	-0.8	-0.3	-0.3
Number of children fathered	1.5	1.7	6.0	2.4	0.7	1.8	1.6	1.1	0.6	-0.9	1.0	0.8	-1.5	-0.7	-1.3	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.2	0.7	0.5	-0.3	1.1	-0.5	0.3	0.4	0.1	-0.8	0.1	-0.9	0.1	0.1
Age at first live birth	1.2	2.2	6.7	-2.4	-1.3	-1.8	-0.6	-0.3	-1.7	-2.6	-1.5	-0.5	1.9	1.2	-0.6	-0.0
Pulse wave peak to peak time	0.4	0.4	1.4	-0.0	-0.6	-0.4	-0.3	-0.7	-0.9	-0.9	-0.6	-0.6	-0.4	-0.3	-0.7	-1.2
Health satisfaction	0.7	0.9	2.8	0.6	0.9	0.9	0.8	1.0	1.3	1.7	0.8	0.7	-0.4	-0.4	1.2	0.9
Shortness of breath walking on level ground	0.4	0.5	1.9	-0.1	-0.3	-1.4	-0.6	-0.1	-0.6	-1.0	0.1	-0.7	0.7	0.9	-0.9	-0.0
Qualifications: College or University degree	0.1	0.3	1.0	-0.8	0.1	-0.0	0.2	0.9	-0.0	-1.0	0.7	-0.4	-0.3	0.2	0.1	0.5
Eye problems/disorders: None of the above	0.6	0.7	1.4	-0.3	0.7	-0.7	0.9	0.5	0.4	-1.0	-1.0	0.5	0.8	1.2	0.9	1.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.4	1.4	-0.2	0.6	-0.7	0.2	-0.5	-0.9	-0.1	-0.5	-1.2	-1.8	-1.8	-1.7
Emphysema/chronic bronchitis	0.6	0.7	3.4	1.0	0.6	1.1	0.5	0.5	0.5	0.2	-1.2	0.4	-0.8	-1.9	0.1	0.0
Medication for pain relief, constipation, heartburn	0.3	0.5	2.7	1.0	0.6	0.2	0.7	-0.2	-0.1	-1.6	0.6	-1.3	-0.5	-0.0	-0.1	-0.5
Neck or shoulder pain in last month	1.7	2.4	6.1	2.0	1.9	1.2	0.8	0.5	2.5	2.3	0.4	-0.1	-1.0	-1.5	2.1	1.5
Medication: Blood pressure	0.5	0.8	4.8	1.3	0.4	1.2	2.2	-0.5	0.6	0.7	-0.0	0.3	-1.0	-0.3	0.4	-0.4
Angina (self-reported)	1.4	1.9	6.9	1.9	1.5	1.3	2.6	1.7	1.5	1.4	-0.1	-0.3	-1.1	-1.0	-0.4	0.3
Migraine (self-reported)	1.1	1.4	5.2	1.7	0.2	1.0	-0.4	-1.4	0.3	-0.5	2.3	-1.6	-0.4	-1.5	-0.4	-1.3
Medication: Ibuprofen	0.8	1.0	5.0	-1.4	-0.9	-0.6	-0.6	-0.0	-0.4	-0.0	-2.2	1.7	1.1	0.2	-0.6	0.4
Medication: Allopurinol	0.4	0.6	3.8	-0.4	0.8	-0.3	0.5	-0.7	0.6	0.0	0.0	0.1	0.9	0.2	1.9	1.0
Medication: Omeprazole	0.4	0.4	1.8	1.2	0.7	-0.1	-1.2	-0.3	0.4	0.3	0.2	-0.1	0.1	-1.3	-0.1	0.1
Medication: Seretide 50 evohaler	1.8	2.1	5.4	-1.3	-1.2	-2.1	0.3	-1.4	-1.6	-1.5	-2.3	-0.6	2.0	1.4	-0.7	-0.5
Mean time to correctly identify matches	1.0	2.0	4.3	-1.2	-1.2	-1.8	0.8	-1.4	-1.8	-2.1	-1.0	-1.8	1.6	0.5	-0.8	-1.2
Heart disease (mother)	1.8	2.2	7.6	0.4	1.2	0.0	1.6	1.6	1.4	2.8	2.1	-0.2	0.2	-1.2	1.2	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	13.8	0.9	0.6	-0.7	0.1	-1.2	0.5	0.1	-0.9	3.7	0.4	1.1	1.0	0.6
Whole body fat mass	0.2	0.9	3.1	0.7	1.2	0.9	0.2	1.0	1.2	1.8	0.7	0.2	-0.3	-0.9	0.5	1.0
Leg fat mass (right)	0.6	2.3	5.5	1.6	2.1	1.4	0.5	1.4	2.1	2.3	1.5	-0.1	-0.7	-1.3	1.3	1.6
Arm predicted mass (right)	0.1	0.7	2.7	-0.9	-0.4	-0.8	-0.6	-1.6	-0.7	-0.0	-0.8	-0.4	1.6	0.4	0.2	0.2
Pulse rate, automated reading	0.7	2.2	8.2	-2.9	-2.1	-1.5	-0.6	0.2	-1.6	-0.4	-2.1	-1.1	1.4	1.3	-1.2	0.1
Alcohol intake frequency.	0.7	1.6	9.6	1.3	0.4	-0.2	-0.9	-2.4	0.0	-0.1	-0.1	-3.1	0.4	-1.8	0.2	-0.6
Comparative height size at age 10	0.2	1.2	4.6	-0.6	-1.0	0.7	0.6	-1.9	-0.9	-0.7	-1.3	-0.5	0.5	2.1	0.7	-1.3
Number of full sisters	0.5	0.6	2.4	0.1	0.0	-0.1	1.1	-1.1	0.3	1.6	1.1	-0.0	0.7	0.5	1.1	0.5
Suffer from ‘nerves’	0.4	0.6	2.4	0.6	0.5	1.5	-0.4	1.1	0.4	0.3	0.8	1.1	-1.2	0.1	-0.3	-0.6
Overall health rating	5.4	11.6	22.6	4.5	4.4	3.1	2.4	0.7	4.8	4.7	2.7	1.1	-2.2	-3.5	4.0	2.8
Chest pain or discomfort	0.3	0.5	1.6	1.3	0.9	-0.1	0.4	-0.3	0.7	0.4	-1.0	0.1	-0.3	-1.1	-0.3	0.4
Had major operations	3.5	4.1	9.1	-2.0	-2.0	-2.8	-1.6	-2.0	-2.6	-2.3	-3.0	-0.2	1.9	1.4	-1.6	-1.4
Age at last live birth	0.9	1.3	5.2	-1.1	-1.8	-0.4	0.1	-0.5	-1.8	-2.3	0.1	-0.5	0.1	0.5	-0.9	-1.6
Family relationship satisfaction	0.2	0.2	0.6	-0.6	0.0	-0.1	-0.1	0.8	0.1	0.4	-0.4	0.3	0.4	-0.6	0.7	0.7
Leg pain on walking	0.6	0.7	2.2	-1.1	-0.8	-0.7	-1.0	-0.4	-0.8	0.1	-0.5	1.4	-0.1	-1.5	-0.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.7	-0.7	-0.6	-0.5	-1.3	0.4	-0.3	0.3	0.3	0.8	0.5	-1.3	0.0	0.1
Commuting to job workplace: Car/motor vehicle	2.4	2.7	6.8	2.1	2.6	1.1	0.7	0.6	2.4	1.9	1.5	1.1	-0.6	-1.1	2.2	1.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	0.4	-0.1	0.7	0.4	0.4	-0.2	-0.9	0.8	0.8	-0.4	0.5	-0.3	-1.0
Medication: Aspirin	0.6	0.8	5.3	0.8	0.5	-0.3	-0.4	1.0	0.6	1.3	-0.0	2.3	0.2	1.2	0.2	0.4
Supplements: Vitamin C	0.8	1.0	3.9	-1.0	-0.6	-0.9	-0.4	-0.8	-0.8	-1.4	-2.0	1.1	1.3	-0.3	-0.5	-0.1
Knee pain experienced in last month	0.4	0.6	2.1	-0.2	0.1	0.2	-0.1	1.2	0.2	0.5	1.1	-0.8	-1.4	-1.4	-0.7	0.0
Hypertension (Self-reported)	0.6	1.7	6.0	1.6	0.5	1.9	2.1	0.1	0.5	0.3	0.7	-0.1	-1.7	-2.5	0.0	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	7.4	1.8	0.3	2.1	-1.3	0.3	0.3	-0.0	1.5	-0.1	-2.7	-1.5	-1.4	-1.7
Illnesses of father: Heart disease	0.2	0.3	1.0	-0.5	-0.2	-0.3	-0.7	1.0	-0.0	0.7	-0.1	-0.7	0.1	0.5	-0.4	0.7
Illnesses of siblings: Diabetes	1.0	1.2	4.8	0.5	-0.6	2.2	1.0	-0.3	-0.4	0.1	-0.6	0.7	-1.9	-1.0	-0.6	-1.9
Smoking status: Previous	0.8	1.2	7.1	1.5	1.2	0.5	2.7	-0.2	1.2	0.6	1.3	0.2	-0.4	-0.9	0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	10.4	-2.2	-1.8	-0.3	0.2	-1.1	-1.7	-0.3	-3.2	0.6	0.5	1.0	-0.2	-0.9
Whole body fat-free mass	0.3	1.6	5.5	-1.5	-0.7	-1.6	-0.7	-1.9	-1.2	-0.8	-1.4	-1.1	2.4	0.3	-0.1	0.3
Leg fat-free mass (right)	0.3	1.7	6.5	-1.7	-0.7	-1.7	-1.0	-1.7	-1.1	-0.6	-1.7	-1.1	2.5	-0.3	-0.0	0.4
Arm fat percentage (left)	0.5	2.1	5.4	1.3	1.6	1.0	-0.0	1.9	1.7	2.0	1.7	-0.3	-0.7	-2.3	0.5	1.3
Average weekly red wine intake	0.7	1.1	3.9	-0.5	-0.1	0.5	-1.4	0.8	0.2	-0.8	1.7	-1.6	-0.9	-2.0	0.5	0.2
Handedness (chirality/laterality): Left-handed	1.2	1.5	5.5	2.3	1.7	1.3	1.0	0.2	1.5	0.6	1.2	-0.7	-1.2	-0.8	1.0	0.6
Mood swings	1.0	1.8	6.0	1.0	1.0	1.7	0.4	1.2	1.2	1.7	-0.2	0.1	-2.4	-2.3	0.6	0.3
Loneliness, isolation	1.1	1.5	4.7	-0.3	1.3	0.3	-0.3	2.2	1.2	1.6	-0.2	1.9	-0.1	0.8	1.0	1.8
Long-standing illness, disability or infirmity	0.2	0.4	1.3	1.1	0.8	0.3	-0.0	-0.7	0.6	-0.1	-0.3	-0.2	-0.1	-1.1	0.6	0.2
Ever had bowel cancer screening	1.0	1.2	4.8	0.9	0.9	0.6	2.2	-1.0	0.8	0.2	2.2	0.7	-0.4	0.9	0.7	0.2
Diabetes diagnosed by doctor	0.6	1.1	3.0	1.1	1.2	1.4	-0.2	0.3	1.4	0.9	-0.0	-1.7	-0.6	-0.6	1.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	6.9	2.3	2.1	1.8	2.1	2.3	2.1	1.4	1.5	-0.0	-1.9	-2.6	0.2	0.7
Friendships satisfaction	0.6	0.8	3.3	-0.3	1.1	-1.0	-0.2	-0.1	0.8	0.7	0.1	-0.1	1.2	-0.7	1.2	1.8
Qualifications: nursing, teaching	0.8	1.2	4.0	0.8	1.3	1.2	1.3	2.0	1.6	1.0	0.0	0.0	-1.3	0.0	0.1	1.2
Commuting to job workplace: Walk	0.4	0.4	1.5	0.7	-0.2	-0.1	-1.2	-0.2	-0.3	-1.1	0.3	-1.1	-0.4	-0.1	-0.5	-0.8
Eye problems/disorders: Cataract	1.0	1.2	5.2	1.1	-0.2	1.2	-0.2	0.2	-0.0	0.1	2.3	0.3	-1.7	-1.4	-1.1	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	-1.3	-0.8	0.2	0.7	0.7	-0.1	1.1	-0.4	0.5	-0.7	0.9	1.0	0.3
Medication for cholesterol	2.1	3.2	8.7	-2.6	-1.8	-2.7	-1.1	-0.9	-2.1	-1.8	-1.6	0.3	1.9	2.9	-0.9	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	4.7	-0.2	1.1	1.4	0.9	0.7	1.3	1.5	0.8	-2.2	-0.7	-1.4	2.1	1.1
Back pain experienced in last month	0.5	0.7	3.8	-0.4	-0.2	0.1	-0.2	1.5	0.4	1.6	-2.0	0.3	-0.2	0.0	0.5	0.6
Mineral and other dietary supplements	1.4	1.9	9.5	-0.5	-1.8	-0.0	-0.4	-0.3	-1.8	-1.3	-0.7	0.1	-0.6	0.2	-3.1	-2.3
Breast cancer (self-reported)	0.6	0.8	3.2	1.2	0.3	0.1	0.3	-0.3	-0.1	-0.4	-0.9	-1.6	-0.5	-1.8	-0.5	-0.7
Asthma (self-reported)	1.3	2.6	11.2	-1.1	-1.8	-1.2	-0.3	-0.4	-1.9	-1.4	-3.4	1.0	0.2	-1.1	-2.5	-1.5
Osteoporosis (self-reported)	0.2	0.3	1.8	0.2	0.5	-0.1	0.0	0.2	0.6	0.9	0.3	-0.1	0.2	-0.0	1.4	0.6
Osteoarthritis (self-reported)	0.4	0.6	3.3	-0.6	-1.1	-0.4	0.3	-0.8	-0.6	-0.2	-0.0	0.1	0.8	0.2	-1.8	-0.6
Medication: Aspirin	0.5	0.6	5.0	0.8	0.6	-0.3	-0.1	0.5	0.5	0.9	-0.5	2.2	0.1	0.7	0.3	0.3
Medication: Gliclazide	0.7	0.8	1.7	1.1	0.7	1.2	1.3	0.6	1.0	0.8	0.1	-0.6	-0.9	-1.1	1.1	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.4	1.6	0.6	0.3	0.7	-0.9	0.6	0.7	0.8	0.2	1.2	-0.8	-0.3	0.2	0.1
Smoking status: Current	0.6	0.9	3.7	1.1	0.7	1.9	0.3	0.9	1.0	1.1	0.1	-0.1	-1.5	-0.5	0.6	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.1	-1.8	-0.8	-0.8	-0.5	-0.2	-1.4	-1.4	-1.4	-0.1	0.3	-0.1	-0.8	-0.6
Whole body water mass	0.3	1.5	5.4	-1.4	-0.7	-1.6	-0.8	-1.9	-1.1	-0.7	-1.3	-1.2	2.3	0.2	-0.1	0.3
Leg predicted mass (right)	0.3	1.6	5.8	-1.6	-0.8	-1.6	-0.8	-1.7	-1.1	-0.6	-1.6	-1.1	2.4	-0.4	-0.1	0.3
Arm fat mass (left)	0.2	1.0	2.6	0.7	1.2	0.3	-0.3	1.1	1.1	1.6	1.0	-0.2	0.3	-1.6	0.5	1.4
Number of self-reported non-cancer illnesses	0.9	1.5	4.3	1.8	1.0	2.1	1.2	-0.3	1.1	1.1	1.2	0.4	-1.4	-1.6	0.4	-0.5
Average weekly champagne plus white wine intake	1.3	1.8	6.1	0.1	0.9	-1.6	-0.9	-1.0	0.9	0.5	1.9	-0.4	1.6	1.7	1.2	2.5
Miserableness	0.4	0.7	2.4	-1.0	0.4	-0.4	-0.3	0.3	0.5	1.5	-0.8	0.3	0.2	-0.7	1.2	1.6
Guilty feelings	0.7	1.1	3.5	0.1	1.0	1.1	0.7	0.4	1.0	1.8	0.1	1.9	-0.7	0.4	1.3	0.8
Wears glasses or contact lenses	0.5	0.5	2.2	1.5	0.3	0.8	1.4	0.4	0.7	0.6	-0.2	-0.6	-0.5	0.5	-0.6	-0.4
Ever taken oral contraceptive pill	0.5	0.5	2.1	-0.6	-0.0	-0.3	-0.5	-0.7	0.4	0.8	-0.5	1.5	0.1	0.6	1.1	1.0
Hearing aid user	0.8	0.9	5.5	0.4	0.0	-0.5	-0.7	-0.6	-0.1	-0.7	-0.6	-1.9	0.7	-2.3	-0.3	-0.0
Mother’s age at death	0.4	0.5	2.2	0.1	0.4	-0.3	-0.5	-1.5	0.1	-0.3	1.1	0.1	0.4	1.4	0.8	0.3
Financial situation satisfaction	1.4	1.8	6.0	-1.3	-0.3	-1.7	-0.3	-1.6	-0.3	0.1	-1.8	-0.8	2.4	-0.7	2.1	1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	3.1	0.4	0.5	0.7	0.4	1.0	0.3	-0.0	0.1	1.8	-0.3	-1.2	-0.2	0.1
Commuting to job workplace: Public transport	1.5	1.8	4.0	-2.0	-1.7	-1.7	-1.5	-0.8	-1.8	-1.4	-1.3	-0.3	1.5	1.2	-0.4	-0.4
Eye problems/disorders: Glaucoma	0.6	0.7	3.0	-0.6	-0.8	-1.0	0.2	-1.7	-0.5	0.2	-0.2	-1.1	1.2	0.7	0.7	0.3
Medication: Blood pressure	1.4	2.7	7.4	2.7	1.7	1.6	2.1	0.9	1.8	1.0	2.0	-0.6	-1.2	-2.7	-0.0	0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.1	-0.6	-0.3	-0.3	-0.3	0.3	-0.4	-0.9	-1.4	0.4	0.2	-1.0	-1.1	-0.1
Supplements: Fish oil (including cod liver oil)	1.8	2.3	6.6	1.1	2.1	0.8	1.1	1.2	2.2	1.7	0.8	0.5	-0.4	-1.0	2.6	2.1
High cholesterol (Self-reported)	0.4	0.8	2.8	1.2	0.3	1.7	0.5	-0.1	0.7	1.3	-0.0	0.5	-1.3	-0.1	1.1	-0.6
Medication: Bendroflumethiazide	0.5	0.7	2.7	1.6	1.1	0.5	1.1	-0.1	0.9	-0.0	0.2	0.4	-0.6	-1.5	-0.4	0.2
Medication: Paracetamol	0.5	0.8	2.0	-1.3	-1.4	0.2	-1.3	-0.2	-0.8	0.0	-1.1	0.2	0.4	-1.1	-0.9	-0.7
Medication: Lisinopril	0.4	0.5	3.0	0.2	0.8	0.5	1.7	0.5	0.8	0.2	-0.5	0.3	0.3	-0.7	0.5	0.7
Medication: Atorvastatin	0.1	0.2	0.6	0.5	0.0	-0.6	-0.2	-0.6	0.1	0.4	-0.1	-0.7	-0.2	-0.0	0.8	0.1
Illnesses of father: High blood pressure	2.0	2.4	10.6	1.9	1.2	2.1	3.2	0.2	1.3	1.2	0.6	-0.6	-1.9	-1.8	0.8	-0.5
Alcohol drinker status: Never	1.0	1.2	5.9	-0.3	-0.4	0.4	-0.1	0.1	-0.4	0.6	1.3	-2.3	-0.6	-2.4	-0.8	-0.6
Ever smoked	0.7	1.2	4.3	1.8	0.2	0.7	1.6	-0.6	0.1	-1.3	2.1	-0.8	-0.7	-0.4	-0.9	-0.9
Basal metabolic rate	0.2	0.9	4.2	-1.2	-0.4	-1.2	-0.7	-1.4	-0.8	-0.3	-1.1	-0.9	2.0	0.0	0.0	0.5
Leg fat percentage (left)	1.5	5.5	10.9	2.6	3.1	2.4	1.1	2.6	3.2	3.3	2.6	0.7	-2.0	-1.7	1.5	2.0
Arm fat-free mass (left)	0.2	0.8	4.1	-0.9	0.1	-1.2	-0.3	-1.5	-0.3	0.1	-0.5	-0.5	2.0	0.5	0.4	1.0
Number of operations (self-reported)	0.8	1.2	2.2	-0.7	-1.3	-1.3	0.8	-1.4	-1.4	-1.5	-1.1	0.0	0.9	0.2	-1.2	-1.3
Average weekly beer plus cider intake	1.4	2.0	5.4	2.1	0.1	1.8	-0.4	0.7	-0.1	-0.5	-1.1	-0.7	-2.0	-1.2	-2.3	-2.1
Irritability	0.5	0.8	3.6	-0.6	-0.3	-1.1	-1.9	-1.1	-0.5	-0.9	0.0	-0.2	1.2	1.0	0.3	0.1
Risk taking	0.2	0.3	2.0	0.8	0.3	-0.4	0.1	-0.5	0.0	-0.7	-0.5	-1.4	0.3	-0.2	-0.2	0.2
Ever had prostate specific antigen (PSA) test	1.4	1.7	5.7	1.5	0.9	0.8	1.8	1.6	0.7	-0.3	1.1	-1.6	-2.4	-1.0	-0.8	-0.4
Fractured/broken bones in last 5 years	0.6	0.8	4.2	0.7	0.7	0.3	-0.2	-0.9	0.6	0.4	0.9	-2.0	0.3	-1.6	0.9	0.3
Age started oral contraceptive pill	0.7	0.9	3.4	-0.2	0.1	-0.9	-1.2	-0.3	0.3	0.1	1.9	-0.7	1.3	1.4	0.7	0.8
Diastolic blood pressure, automated reading	0.2	0.8	2.5	0.6	1.0	0.6	0.2	1.6	0.6	0.3	1.6	0.6	-0.1	-1.4	0.3	0.6
Ever depressed for a whole week	0.2	0.2	0.6	-0.3	0.0	-0.3	-0.8	-0.4	0.1	-0.4	0.8	0.3	0.4	-0.4	0.5	0.2
Unable to work because of sickness or disability	0.4	0.6	2.0	0.6	0.2	0.9	-0.6	-1.0	0.5	0.8	-1.1	0.3	0.4	-1.4	0.8	-0.2
Commuting to job workplace: Cycle	2.3	2.8	9.7	-3.1	-2.4	-1.7	-1.2	-0.5	-2.1	-1.1	-1.6	-0.4	1.9	1.5	-1.3	-0.5
Myopia	1.2	1.7	6.2	-0.2	-1.2	1.4	2.5	0.5	-0.8	-0.9	0.3	-2.0	-1.8	0.5	-1.0	-1.6
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.9	-2.2	-1.1	-2.0	-2.1	-0.1	-1.0	-0.7	-1.5	-0.3	1.6	2.1	-0.3	0.7
Cholesterol lowering medication	0.3	0.5	1.7	0.5	-0.2	0.9	0.2	0.1	-0.1	0.3	-0.7	-1.3	-0.6	-0.9	-0.3	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	3.1	1.8	1.2	0.7	-0.3	-0.2	1.1	0.5	0.5	-0.3	-0.5	-1.6	0.2	0.4
Pain experienced in last month	1.6	2.6	8.8	-0.5	-1.2	-1.3	-1.2	-2.2	-2.0	-3.0	1.3	-1.3	1.1	2.0	-1.1	-1.5
Supplements: Calcium	2.1	2.3	5.9	-2.4	-1.8	-1.7	-1.0	-0.7	-1.6	-1.2	-2.0	-0.4	2.1	2.1	0.8	0.0
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	-0.0	0.6	-0.5	-0.2	-0.4	0.7	0.7	-1.0	0.4	0.6	-0.1	0.4	1.0
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.2	0.3	-0.7	1.3	1.8	-0.9	-0.3	0.5	-0.3	1.4	-1.2	-0.6	-0.7	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.5	-0.9	-0.7	-0.6	-0.4	0.1	-0.6	0.0	0.4	0.0	0.8	1.2	-0.3	-0.2
Heart disease (siblings)	2.5	3.0	8.0	2.6	2.4	1.8	0.9	0.5	2.4	1.2	2.8	-1.0	-1.5	-1.5	1.0	1.0
Alcohol drinker status: Previous	2.2	2.5	8.5	1.9	0.9	1.9	-1.0	-0.2	1.1	1.0	2.9	-2.7	-0.7	-1.9	1.1	-0.6
Pack years of smoking	0.9	1.3	2.8	1.7	0.6	1.5	0.4	0.5	1.0	0.8	1.5	-1.5	-1.4	-1.4	0.4	-0.3
Impedance of whole body	0.7	3.6	10.3	-1.2	-2.3	1.3	0.5	-0.1	-1.6	-1.0	-2.4	3.2	-1.6	2.6	-1.5	-2.7
Leg fat mass (left)	0.6	2.4	5.5	1.7	2.2	1.4	0.6	1.4	2.1	2.3	1.4	0.1	-0.6	-1.4	1.3	1.7
Arm predicted mass (left)	0.1	0.7	3.6	-0.8	0.0	-1.1	-0.3	-1.4	-0.4	-0.0	-0.4	-0.5	1.9	0.1	0.2	0.9