Hub : Genes

RNF24

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1990 0.0390 1.2e-11 0.142 0.101 0.125 0.119 0.132 6.9e-17 2.7e-12 6.3e-15 2.9e-14 1.0e-15
2 GTEx Adipose Subcutaneous 0.1320 0.0450 2.6e-03 0.074 NA 0.024 NA 0.044 1.1e-06 NA 4.3e-03 NA 1.5e-04
3 GTEx Brain Caudate basal ganglia 0.3230 0.0900 1.1e-03 0.267 NA 0.209 NA 0.260 2.6e-08 NA 1.2e-06 NA 4.2e-08
4 GTEx Brain Cortex 0.4590 0.1240 1.4e-03 0.000 NA 0.064 NA 0.041 3.2e-01 NA 7.5e-03 NA 2.8e-02
5 GTEx Cells Transformed fibroblasts 0.3090 0.0580 1.1e-07 0.082 NA 0.181 NA 0.206 1.0e-06 NA 1.6e-13 NA 2.0e-15
6 GTEx Nerve Tibial 0.1971 0.0532 4.4e-05 0.096 NA 0.112 NA 0.119 2.7e-07 NA 2.5e-08 NA 9.0e-09
7 GTEx Skin Sun Exposed Lower leg 0.1380 0.0420 4.7e-04 0.083 NA 0.087 NA 0.076 2.0e-07 NA 1.1e-07 NA 7.5e-07
8 GTEx Thyroid 0.2210 0.0540 3.3e-05 -0.002 NA 0.024 NA 0.007 5.1e-01 NA 5.9e-03 NA 9.4e-02
9 GTEx Vagina 0.5350 0.1220 3.9e-04 0.003 NA 0.002 NA -0.013 2.8e-01 NA 2.8e-01 NA 8.9e-01
10 ROSMAP Brain Pre-frontal Cortex 0.2927 0.0385 0.0e+00 0.273 0.181 0.290 0.276 0.288 4.1e-35 1.1e-22 1.5e-37 1.6e-35 2.3e-37
11 YFS Blood 0.0996 0.0189 1.5e-15 0.045 0.056 0.072 0.074 0.066 1.6e-14 8.0e-18 1.7e-22 3.6e-23 1.1e-20
12 TCGA Lung Squamous Cell Carcinoma 0.0480 0.0290 3.9e-03 0.005 0.018 0.012 NA 0.011 8.0e-02 3.7e-03 1.5e-02 NA 1.9e-02
13 TCGA Thyroid Carcinoma 0.0370 0.0190 2.3e-03 0.020 0.020 0.009 NA 0.021 4.2e-03 4.4e-03 4.1e-02 NA 3.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.9 1.4 4.5 2.1 1.7 1.1 1.0 0.4 1.3 0.8 -0.1 -1.4 -0.8 -1.7 0.5 0.1
Bipolar Disorder or Schizophrenia 1.8 4.5 13.7 3.5 2.5 2.6 2.4 0.8 2.1 1.2 -0.3 -0.6 -2.3 -3.7 0.6 -0.4
Depressed Affect (Nagel 2018) 0.5 1.0 2.7 0.1 0.6 1.5 -0.5 1.5 1.0 1.6 -0.4 0.0 -1.2 -0.6 1.2 0.7
Depression (Nagel 2018) 1.5 2.2 5.5 1.4 2.4 1.4 -0.2 2.1 2.1 1.9 0.9 0.2 -1.2 -1.0 1.1 1.6
Intelligence (Savage-Jansen 2018) 1.8 5.6 13.0 -3.5 -1.3 -3.6 -2.0 -0.6 -2.1 -2.4 -2.5 -2.8 3.0 2.5 -0.7 1.0
Neuroticism (Nagel 2018) 0.7 1.7 4.8 0.3 1.2 2.2 -0.5 1.3 1.5 1.9 0.9 0.6 -1.8 -0.2 1.7 0.7
Schizophrenia (2018) 1.7 3.4 11.2 2.8 1.9 2.4 2.3 0.7 1.7 0.9 -0.3 0.7 -2.4 -3.3 0.3 -0.6
Schizophrenia vs Biploar Disorder 0.5 0.7 2.3 0.6 -0.1 1.3 0.8 -0.3 0.0 0.2 -1.1 1.5 -1.0 -0.3 0.3 -1.2
Worry (Nagel 2018) 0.7 1.5 5.9 0.6 0.8 2.4 -0.4 1.7 1.0 1.5 0.8 -0.4 -2.0 0.0 0.9 -0.3
Alzheimer’s Disease (in mother) 0.2 0.3 1.9 -0.0 0.3 -0.5 -0.5 -0.0 0.0 -0.1 -0.5 -1.4 0.5 -0.3 -0.2 0.4
Alzheimer’s Disease (in father) 0.6 0.6 2.9 0.9 0.9 0.5 1.7 0.1 0.7 -0.1 -0.7 -0.0 -0.1 0.2 1.5 0.4
Alzheimer’s Disease (including proxy) 0.3 0.4 1.4 0.6 0.6 0.3 1.2 -0.0 0.6 0.3 -0.4 -0.6 -0.1 0.3 1.1 0.4
Crohns Disease (2017) 0.1 0.3 1.4 -0.4 -0.7 0.1 1.2 -0.6 -0.5 0.2 -0.2 0.6 -0.7 -0.1 -0.5 -0.6
Irritable Bowel Disease (IBD) 0.3 0.8 2.9 -1.7 -0.8 -1.3 0.6 -0.3 -0.8 -0.1 -1.0 -0.4 1.2 0.4 -0.8 0.4
Ulcerative Colitis (UC) 0.6 1.1 4.5 -1.7 -0.3 -1.7 0.2 0.6 -0.5 0.2 -1.0 -0.7 2.1 0.2 -0.6 1.0
Major Depression (MDD) 1.2 1.5 6.8 1.0 -0.7 1.2 -0.2 -0.6 -0.8 -0.9 -0.5 -1.1 -1.8 -1.0 -1.2 -2.6
Reaction Time 1.1 2.1 5.3 -1.5 -1.4 -1.6 0.5 -1.6 -1.9 -2.3 -1.6 -1.2 1.4 0.7 -0.8 -1.3
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.4 -1.0 0.2 -1.4 -0.6 0.3 -0.2 -0.1 -0.6 -1.8 0.7 1.4 -0.3 1.2
Breast Cancer 0.4 0.9 3.1 0.3 -0.8 0.2 1.4 0.2 -0.8 -0.3 -0.3 1.1 -0.8 1.8 -1.3 -1.2
Ovarian Cancer 1.1 1.5 4.4 -1.4 -0.1 -1.7 -0.5 -2.1 -0.5 -0.7 -0.9 1.0 1.8 0.3 1.6 1.0
Prostate Cancer 0.3 0.5 1.6 1.3 0.9 0.3 1.2 0.5 0.8 0.4 -0.7 0.1 -0.5 0.1 0.1 0.5
Age at First Birth 0.6 0.9 3.8 -0.3 0.2 -0.7 -0.8 -0.9 0.1 -0.4 1.9 -1.4 1.1 0.7 1.0 0.7
Bipolar Disorder (2011) 0.7 0.7 3.0 -0.8 -0.6 -0.5 -0.7 -0.7 -0.6 0.2 -1.6 -1.7 0.6 -0.1 -0.3 -0.3
Body Mass Index (BMI) (2010) 0.3 0.4 1.3 0.6 0.3 0.5 -0.3 -0.7 0.7 -0.0 1.0 -1.1 0.1 -0.7 1.1 0.3
Coronary Artery Disease (CAD) 0.4 0.5 1.3 -0.1 -0.9 0.1 -1.0 -0.1 -0.8 -0.4 -0.3 0.4 -0.6 -0.7 -1.0 -1.2
Crohns Disease (2012) 0.1 0.2 0.6 -0.2 -0.3 0.1 0.3 -0.8 -0.1 0.8 -0.6 -0.6 -0.1 -0.7 0.2 -0.2
Mean Putamen Volume 0.6 0.7 3.8 1.0 0.7 -0.4 0.7 -1.1 0.4 -0.3 2.0 1.1 0.7 -0.2 0.2 0.5
Fasting Glucose 1.0 1.2 3.1 0.2 1.0 0.9 1.3 1.7 1.1 1.2 1.4 -0.8 -0.8 -1.8 -0.1 0.9
HbA1C 0.7 0.8 2.9 0.7 0.8 0.8 1.1 0.8 1.0 1.7 0.8 -0.1 -1.1 -0.5 0.8 0.6
HDL Cholesterol 0.7 1.2 4.2 -0.5 -0.8 -0.8 -0.2 -0.9 -1.2 -1.6 -2.0 1.5 0.8 0.3 -0.3 -1.0
LDL Cholesterol 1.2 1.9 5.0 1.5 2.0 0.7 0.4 2.2 2.1 1.0 1.0 1.5 -0.6 0.4 0.6 1.8
Lupus 0.8 1.2 5.2 -0.7 -1.0 -0.7 0.4 -2.3 -1.3 -1.8 0.3 0.7 1.0 0.8 0.3 -1.0
Neuroticism (2016) 0.3 0.4 1.8 -0.1 0.4 0.1 -0.6 0.0 0.5 0.6 -1.0 0.8 0.1 -0.3 1.3 0.4
Primary Biliary Cirrhosis 1.0 1.4 10.7 1.6 1.2 0.4 0.4 -0.1 1.1 0.1 1.2 -3.3 -0.3 -0.5 0.4 0.2
Rheumatoid Arthritis 0.4 0.5 3.6 0.0 0.1 -0.1 -0.3 0.7 -0.0 -0.7 1.9 -0.8 -0.1 -1.0 -0.7 0.1
Schizophrenia (2014) 1.4 3.0 11.6 2.4 1.8 2.4 1.4 0.2 1.7 1.7 -0.6 0.1 -1.7 -3.4 0.9 -0.4
Triglycerides 0.3 0.5 1.1 -1.0 -1.1 -0.2 -0.6 -0.3 -0.8 -0.9 -0.3 0.7 0.2 1.0 -0.4 -0.5
Type 2 Diabetes (T2D) (2012) 0.8 1.0 4.2 -2.1 -1.2 -0.6 -1.3 0.1 -0.8 -0.4 -0.1 0.8 0.9 1.2 1.0 0.1
Ulcerative Colitis 0.3 0.4 1.9 -0.9 -0.4 -0.0 -0.2 -0.0 -0.1 0.2 -0.7 -1.4 1.0 -0.3 -0.5 0.1
Blood Eosinophil Count 0.3 1.9 5.8 -2.1 0.5 -1.4 -1.6 0.6 0.5 1.8 0.0 1.4 1.3 1.0 1.4 2.4
Blood Platelet Count 0.3 3.1 13.6 1.0 -1.0 3.0 -0.7 2.1 0.0 1.5 1.4 0.2 -3.7 -0.4 -1.9 -1.8
Blood Red Count 0.1 1.0 5.4 -1.2 -1.0 -1.0 0.8 -0.7 -1.2 -0.8 0.3 -0.5 0.9 2.3 -0.2 -0.5
Blood White Count 0.3 2.1 12.2 -0.3 -0.2 0.5 -1.6 1.8 0.1 0.7 3.5 -0.1 -0.7 2.8 -0.4 0.1
Heel T-Score 0.9 7.2 21.3 4.0 1.7 4.6 4.3 0.7 2.0 1.6 0.5 1.9 -4.1 -1.6 -0.4 -2.0
BMI 0.8 4.4 13.0 1.2 2.5 0.3 -0.0 1.5 2.7 3.6 2.6 -0.6 0.0 -1.9 2.1 3.3
Height 0.5 9.2 34.6 -3.5 -3.2 -1.7 -0.3 -2.5 -3.2 -2.4 -5.9 1.1 3.2 4.5 -1.4 -1.8
Waist Hip Ratio (WHR) 1.2 5.3 16.9 -4.1 -3.3 -1.8 -2.1 0.4 -2.7 -0.8 -1.9 1.5 1.9 3.7 -1.5 -0.7
Systolic Blood Pressure 0.2 1.2 6.5 1.3 -0.7 1.4 1.2 -0.6 -0.8 -0.2 -0.0 0.2 -1.0 -1.1 -0.7 -2.5
Smoking Status 0.2 0.4 1.3 0.9 0.5 1.1 1.1 -0.0 0.6 -0.0 -0.2 0.9 -0.6 -0.7 0.4 0.0
Allergy or Eczema 0.4 1.2 4.3 -0.9 -0.4 -0.7 1.2 -1.4 -0.2 -0.6 -0.9 2.1 1.6 1.4 0.7 0.5
Cardiovascular Disease 0.7 2.3 6.3 2.5 1.7 2.1 1.5 0.1 1.7 1.1 1.1 0.5 -1.5 -2.1 1.4 0.0
Hypothyroidism (self reported) 1.0 2.4 11.0 0.5 1.5 0.2 -0.9 1.5 1.4 1.3 3.3 -2.4 -0.3 -0.7 1.2 1.7
Respiratory disease 1.3 2.8 7.7 -1.2 -2.1 0.1 -0.8 -0.2 -2.1 -1.2 -2.8 0.6 -0.7 -1.7 -2.6 -2.4
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.3 0.6 0.7 0.8 -0.9 -0.1 1.0 1.5 1.1 -0.2 -0.1 -0.1 1.4 0.5
Lung FEV1/FVC ratio 0.4 2.1 13.3 -2.1 -1.1 -0.3 -1.1 -0.6 -1.2 -1.0 -3.7 1.7 -0.0 0.8 -0.8 -0.7
Lung FVC 0.2 0.8 3.2 0.6 0.9 0.3 1.0 0.6 -0.1 -1.8 0.5 -1.4 -1.0 -1.2 -0.3 -0.7
Neuroticism 0.1 0.3 1.3 -0.4 0.1 1.2 -0.8 0.7 0.2 0.4 -0.3 -0.1 -1.1 0.4 0.3 -0.2
Chronotype (morning person) 1.2 2.8 6.3 -1.1 0.7 -2.0 0.5 -1.4 0.1 0.3 -2.2 2.5 2.2 2.4 1.9 2.0
Hair Pigment 0.1 3.3 13.0 -3.6 -1.9 -2.6 -2.2 0.1 -1.8 -0.4 0.1 -0.0 2.7 1.8 -0.3 0.8
Tanning 0.1 1.1 3.7 0.6 1.3 -0.1 -0.6 0.2 1.1 1.1 0.1 -0.8 0.5 -1.5 1.9 1.5
Hand grip strength (left) 1.8 4.8 10.9 -1.4 -2.4 -2.0 -0.7 -2.8 -3.0 -3.3 -1.9 -0.2 1.8 2.7 -1.9 -2.0
Number of treatments/medications taken 0.5 0.8 4.0 0.8 0.6 0.9 0.4 0.7 1.1 2.0 -0.8 0.1 -0.4 -1.3 0.4 0.6
Average weekly spirits intake 1.1 1.4 4.0 1.1 0.3 2.0 1.2 1.1 0.5 -0.0 0.9 -0.6 -1.9 -1.9 -0.9 -0.7
Sensitivity / hurt feelings 1.0 1.7 4.5 0.4 1.4 1.4 0.2 2.1 1.6 0.9 0.9 1.5 -1.9 -0.9 1.1 1.2
Frequency of depressed mood in last 2 weeks 2.2 3.0 6.6 1.0 2.4 1.5 0.3 2.6 2.2 2.6 0.4 -0.4 -1.4 -2.0 1.7 1.8
Hearing difficulty/problems: Yes 0.9 1.4 5.1 1.7 1.2 0.7 1.3 0.5 1.5 1.7 0.2 -0.5 -0.4 -2.2 0.7 0.8
Relative age of first facial hair 0.7 1.3 4.9 -2.0 -1.9 -0.6 -0.6 -0.1 -1.4 -0.6 -0.5 1.1 -0.1 2.2 -0.4 -0.6
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.7 -0.1 1.0 -0.0 0.5 0.1 0.9 0.8 0.3 -0.7 0.7 -1.3 0.8 1.3
Ever used hormone-replacement therapy (HRT) 1.1 1.4 3.6 0.5 1.4 0.1 1.1 0.6 1.6 1.9 1.2 0.4 0.3 -1.3 1.2 1.8
Ever had hysterectomy (womb removed) 0.5 0.5 1.8 -1.3 -0.9 -0.3 0.3 0.6 -0.6 0.2 -0.4 0.9 0.2 -1.3 -0.6 -0.2
Systolic blood pressure, automated reading 0.3 0.8 3.3 1.3 0.7 0.8 -0.2 0.2 0.3 0.5 1.8 -1.3 -0.0 -1.5 0.4 -0.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 2.9 0.2 -0.2 -0.1 -1.7 -0.4 0.0 0.7 0.7 -0.5 0.4 0.0 0.3 0.1
Angina 1.6 2.2 7.2 2.2 1.7 1.4 2.7 1.9 1.7 1.4 -0.0 -0.2 -1.2 -1.0 -0.3 0.3
Medication for hormone replacement therapy 2.4 2.7 5.8 1.9 1.5 2.4 -0.4 0.7 2.1 1.7 1.6 -0.4 -1.6 -2.2 2.1 0.8
Vitamin and mineral supplements 0.8 1.0 3.3 1.0 -0.2 1.6 -0.3 0.2 0.1 0.8 1.8 -1.0 -1.4 -0.2 -1.2 -1.3
Supplements: Zinc 1.4 1.5 4.2 -1.1 0.6 -0.8 -0.9 -0.2 0.7 0.6 -0.7 1.5 1.8 1.5 1.7 2.0
Medication: Co-codamol 0.3 0.4 0.8 0.8 0.7 0.2 0.1 -0.6 0.7 0.9 0.0 -0.2 0.3 -0.8 0.9 0.5
Medication: Metformin 0.4 0.6 2.4 0.7 0.4 1.5 -0.4 0.6 0.5 0.5 0.8 -1.3 -1.0 -0.2 0.4 -0.7
Diabetes (father) 0.7 0.9 2.0 1.0 1.2 1.0 0.6 0.2 1.4 1.1 0.8 -0.9 -0.3 0.2 1.3 1.0
Diabetes (mother) 0.9 1.1 5.6 -0.1 -0.5 1.2 -0.3 0.4 -0.5 -0.0 2.4 1.8 -1.1 -0.9 -0.1 -1.1
Severe depression (siblings) 0.1 0.2 0.7 -0.2 -0.2 -0.4 -0.2 0.3 -0.4 -0.8 -0.3 0.3 0.6 -0.1 -0.5 -0.4
Pack years adult smoking proportion 0.5 0.7 1.4 1.1 0.3 1.1 0.3 0.4 0.7 0.8 0.9 -1.2 -1.1 -1.2 0.4 -0.1
Impedance of leg (right) 0.6 2.8 10.0 -0.2 -1.3 1.8 0.5 0.4 -0.7 -0.4 -1.4 3.2 -2.1 3.0 -0.9 -1.9
Leg fat-free mass (left) 0.2 1.3 5.0 -1.5 -0.6 -1.4 -0.8 -1.5 -0.9 -0.4 -1.2 -1.3 2.2 -0.5 0.1 0.5
Trunk fat percentage 0.3 1.1 4.5 0.8 1.1 1.2 0.3 1.4 1.3 2.1 0.6 1.0 -0.8 -0.7 0.3 0.8
Hand grip strength (right) 1.9 5.2 11.6 -2.3 -2.2 -2.8 -1.0 -2.4 -2.9 -3.4 -2.0 0.2 2.4 2.9 -1.7 -1.2
Townsend deprivation index at recruitment 0.4 0.6 1.7 -0.4 -1.3 0.3 -0.5 -0.5 -0.8 0.3 -1.0 0.4 -0.8 -0.8 -1.0 -1.3
Current tobacco smoking 0.5 0.9 3.8 0.9 0.3 1.9 0.3 1.3 0.6 1.0 0.1 -0.3 -1.7 -0.5 0.0 -0.6
Average weekly fortified wine intake 2.8 3.3 7.8 -1.6 -2.4 -0.8 -0.8 -1.3 -2.7 -2.6 -1.4 0.0 0.1 0.6 -2.7 -2.8
Maternal smoking around birth 0.6 0.9 6.2 -0.1 0.6 -0.6 -0.9 0.7 0.5 0.7 -1.1 2.5 0.3 -0.1 0.5 1.1
Fed-up feelings 1.2 2.3 7.2 0.8 1.3 1.8 -0.2 1.8 1.6 2.7 1.2 0.0 -2.0 -1.3 1.7 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 4.3 0.4 1.3 0.7 0.0 1.9 1.1 2.1 0.9 0.1 -1.0 -0.8 0.6 1.2
Relative age voice broke 0.2 0.3 1.6 -1.2 -0.6 -0.2 -0.3 0.5 -0.4 -0.1 -0.7 0.3 0.0 0.2 0.5 0.3
Taking other prescription medications 0.3 0.5 2.1 0.6 0.2 -0.1 0.8 -0.9 0.1 -0.0 -0.3 -1.3 0.0 -1.5 -0.7 -0.2
Age when periods started (menarche) 0.4 1.0 3.3 -1.1 -1.1 -1.8 -1.1 -0.0 -1.0 -0.3 0.3 -0.1 1.0 1.8 -0.3 0.2
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.1 -0.9 -1.0 -0.8 -0.3 -0.2 -1.0 -1.0 -0.4 -1.0 0.3 -1.0 -0.8 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 8.9 3.0 1.0 2.4 2.8 -0.2 0.8 -0.1 0.7 0.8 -2.0 -0.0 -0.6 -1.8
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 5.3 1.2 -0.1 1.0 1.0 -0.6 0.1 -0.2 2.3 -0.2 -1.1 -2.0 -0.6 -1.3
Qualifications: CSEs or equivalent 1.1 1.5 6.0 0.2 0.5 0.9 1.2 0.6 1.2 2.4 0.9 1.8 -1.4 -1.1 1.1 1.0
Serious illness, injury or assault to yourself 0.2 0.3 1.2 -0.0 -0.3 0.3 0.9 -0.2 0.1 0.2 -0.7 -1.1 -0.6 -0.4 -0.4 0.0
High blood pressure 0.7 1.9 6.7 1.7 0.6 2.0 2.1 0.3 0.6 0.3 1.0 0.2 -1.8 -2.6 0.0 -1.1
Hayfever, allergic rhinitis or eczema 0.8 1.7 8.9 -1.3 -0.9 -0.9 0.8 -1.1 -0.9 -0.8 -1.5 3.0 1.1 1.7 0.2 -0.0
Multivitamins +/- minerals 0.5 0.6 2.7 -0.5 0.7 -0.5 0.2 0.4 0.6 0.5 -0.9 0.4 0.4 0.5 1.6 1.5
Stomach or abdominal pain in last month 1.0 1.2 2.8 1.2 1.0 1.1 1.0 0.1 1.5 1.7 1.1 0.3 -0.6 -1.6 0.6 1.0
Supplements: Glucosamine 1.0 1.3 5.8 0.0 1.4 -1.2 0.0 0.3 1.2 0.4 1.3 -0.3 1.3 -0.6 1.3 2.4
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 4.5 0.7 1.1 1.5 1.0 -0.3 1.4 1.6 2.1 -0.8 -0.6 0.1 1.2 1.0
Medication: Atenolol 2.2 2.7 6.5 2.4 1.5 1.6 2.3 -0.9 1.8 1.6 2.5 1.0 -1.2 -1.6 1.1 0.3
Medication: Levothyroxine sodium 1.8 3.0 9.0 1.3 1.9 1.4 1.5 1.7 1.9 2.2 3.0 -0.7 -1.0 -1.6 1.6 1.5
Sitting height 0.5 3.5 11.0 -0.6 -0.8 -0.8 -0.2 -3.3 -1.8 -2.9 -3.2 0.8 1.6 2.2 0.0 -1.7
Chronic bronchitis/emphysema (father) 0.4 0.4 1.9 0.4 0.4 0.1 1.4 -0.6 0.0 -0.9 1.1 -0.1 0.5 -0.4 0.9 -0.2
High blood pressure (mother) 0.4 0.5 1.9 0.1 0.7 -0.3 -0.5 -0.4 0.8 1.4 -0.7 0.3 0.3 -0.1 0.9 1.2
Body mass index (BMI) 0.9 3.7 7.4 1.7 2.6 0.6 -0.0 1.7 2.4 2.7 2.5 -0.9 -0.1 -2.7 1.4 2.6
Impedance of leg (left) 0.7 3.3 14.2 -0.2 -1.1 1.7 0.7 0.1 -0.7 -0.5 -1.9 3.8 -2.0 3.3 -1.0 -1.9
Leg predicted mass (left) 0.2 1.3 4.9 -1.5 -0.6 -1.4 -0.9 -1.5 -0.9 -0.4 -1.3 -1.3 2.2 -0.5 0.1 0.4
Trunk fat mass 0.1 0.6 2.9 0.6 1.0 0.9 0.3 0.8 1.0 1.7 0.3 0.5 -0.3 -0.6 0.4 0.8
Waist circumference 0.2 0.7 2.3 -0.3 0.5 0.1 -0.9 1.4 0.6 1.5 1.1 -0.4 0.5 0.1 0.1 1.2
Number of incorrect matches in round 0.9 1.5 3.4 -1.0 -1.2 -1.8 -0.5 -1.6 -1.6 -1.5 -1.2 1.0 1.2 -0.1 -1.0 -1.0
Past tobacco smoking 0.9 1.7 6.3 -2.2 -1.1 -1.3 -2.5 0.3 -1.1 -0.1 -2.3 0.6 0.9 0.9 0.1 -0.0
Alcohol usually taken with meals 1.1 1.7 7.4 -0.1 1.0 -0.1 -0.3 -0.4 1.4 0.7 0.3 0.5 0.7 2.6 2.7 1.9
Nervous feelings 1.1 2.0 8.5 -0.3 -1.5 1.5 -0.5 0.2 -1.4 -0.2 -1.2 0.8 -1.7 -0.2 -2.3 -2.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 5.3 0.4 1.0 0.5 -1.4 0.9 0.5 0.7 -0.0 -0.4 -0.9 -2.3 0.5 0.4
Hearing difficulty/problems with background noise 3.5 5.6 12.7 3.6 2.7 2.4 2.9 1.2 2.9 3.0 1.1 -0.9 -2.1 -3.2 1.4 0.8
Hair/balding pattern: Pattern 2 0.8 1.0 3.0 0.5 0.7 1.1 0.9 1.4 0.7 1.2 1.7 0.6 -0.6 -1.5 0.7 0.5
Had menopause 0.8 1.0 5.5 -0.4 -0.5 -0.3 0.4 0.4 0.0 0.9 2.3 -2.3 -0.1 0.5 -0.2 0.3
Had other major operations 0.7 0.8 3.4 0.1 -0.2 -1.1 0.6 -1.8 -0.5 -1.3 -1.0 -1.0 1.2 -0.4 -0.1 -0.3
Forced vital capacity (FVC) 0.7 2.7 6.7 -2.0 -1.6 -1.3 -0.9 -1.5 -2.1 -2.6 -2.5 0.5 1.0 1.5 -0.7 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 8.8 3.0 1.3 1.9 2.0 -0.1 0.9 -0.4 -0.1 1.3 -1.5 0.4 -0.5 -1.3
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.0 0.1 -0.1 1.0 -0.2 -0.3 0.1 -0.7 0.5 -0.4 -0.8 -0.8 0.4 -0.6
Qualifications: None of the above 0.3 0.6 1.5 1.2 0.4 0.4 -0.1 -1.1 0.6 1.1 1.0 1.0 0.3 0.3 0.6 -0.1
Financial difficulties in last 2 years 1.2 1.6 5.0 -1.1 -0.6 -2.0 -1.3 -0.5 -0.5 0.0 -2.2 -1.6 1.9 -1.0 -0.2 0.9
Mouth/teeth dental problems 0.8 1.2 3.2 -0.9 0.4 -0.9 -1.5 -0.3 0.6 0.8 1.3 0.4 1.6 -0.3 1.4 1.8
Heart attack 0.8 1.1 4.2 0.5 -0.3 1.5 2.1 -0.7 0.1 1.0 -0.0 1.4 -1.4 -0.7 -0.4 -1.0
Allergy 0.9 2.0 8.3 1.6 1.3 1.1 -0.2 0.7 1.4 1.0 2.5 -2.9 -0.9 -0.8 0.5 0.6
Pain all over the body in last month 0.4 0.4 2.0 0.4 0.3 0.9 -0.2 0.3 0.7 0.9 -0.7 1.4 -0.2 -0.6 0.4 0.0
Diabetes (self-reported) 0.5 0.7 2.4 0.8 1.0 1.3 -0.3 0.6 1.2 1.0 0.3 -0.6 -0.7 -0.4 1.6 0.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 3.7 -0.2 -0.6 0.2 0.4 -1.0 -0.3 -0.6 -0.4 1.9 0.6 0.6 -0.2 -0.4
Medication: Ramipril 1.4 1.9 5.3 2.1 1.2 2.3 1.9 0.1 1.5 1.1 1.3 -0.1 -1.8 -0.8 0.8 -0.1
Medication: Simvastatin 0.5 0.8 2.9 1.1 0.3 1.7 0.1 -0.9 0.6 1.1 -0.3 0.9 -1.1 0.1 1.0 -0.5
Fluid intelligence score 0.3 0.6 2.4 0.0 0.5 -0.0 -1.3 0.8 0.0 -0.6 -1.0 -1.5 -0.9 -0.2 -1.0 0.3
Illnesses of siblings 0.5 0.7 2.4 -0.8 -0.9 -1.3 -0.2 -0.3 -0.8 -0.9 -1.0 -0.0 1.2 1.5 -0.4 0.0
Neuroticism score 0.3 0.6 1.7 -0.6 0.3 0.9 -1.0 1.3 0.4 1.1 -0.8 0.6 -1.1 -0.6 0.3 0.4
Weight 0.1 0.5 1.7 -0.0 0.8 -0.1 -0.3 0.2 0.7 1.2 0.0 -0.3 0.9 -0.6 0.6 1.3
Impedance of arm (right) 0.7 3.3 7.1 -2.3 -2.7 -0.5 -0.2 -0.7 -2.3 -2.1 -2.6 1.4 0.2 2.1 -1.4 -2.0
Arm fat percentage (right) 0.6 2.3 5.5 1.0 1.8 0.7 0.0 1.9 1.9 2.1 1.8 -0.8 -0.3 -2.3 0.9 2.0
Trunk fat-free mass 0.3 1.7 5.3 -1.5 -0.8 -1.6 -0.6 -1.9 -1.3 -1.1 -1.4 -1.3 2.3 0.6 -0.3 0.1
Hip circumference 0.2 0.9 3.2 0.4 1.5 -0.1 -0.4 0.5 1.2 1.0 0.7 -0.8 0.9 -1.0 0.7 1.8
Time employed in main current job 1.0 1.1 4.8 0.1 -0.3 0.9 0.9 0.0 0.2 1.1 2.2 2.1 -1.2 0.3 0.8 -0.5
Alcohol intake versus 10 years previously 0.8 1.2 3.8 0.4 -1.2 -0.2 0.4 -1.4 -1.4 -1.2 -0.7 -0.5 -0.2 0.6 -1.7 -1.9
Father’s age at death 1.6 2.1 6.6 -1.1 -1.5 -1.0 -1.5 -1.8 -1.8 -2.6 0.7 -1.9 0.6 0.7 -1.1 -1.3
Worrier / anxious feelings 0.3 0.6 1.9 -1.2 -0.2 1.0 -0.1 0.9 0.2 1.1 0.5 0.1 -1.4 0.5 1.0 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 3.0 0.0 0.7 0.2 -0.7 -0.3 0.4 0.8 0.6 -0.8 0.2 -1.7 1.1 0.5
Falls in the last year 0.7 1.0 3.3 -0.7 -0.9 -0.8 0.3 -1.8 -0.7 -0.6 -1.8 -0.5 1.4 -0.4 0.7 -0.2
Hair/balding pattern: Pattern 3 0.3 0.4 1.5 -0.4 0.4 -0.8 -1.2 0.7 0.1 -0.5 -1.2 0.0 0.2 0.7 -0.5 0.4
Number of live births 4.1 5.9 12.1 3.5 2.5 2.5 3.4 1.3 2.7 2.8 2.0 -0.3 -3.0 -3.0 0.9 0.8
Forced expiratory volume in 1-second (FEV1) 1.5 5.1 12.8 -3.2 -2.2 -2.3 -1.3 -1.9 -2.8 -3.1 -3.6 0.8 1.7 2.4 -0.8 -1.1
Pulse rate 0.5 0.9 3.4 -1.3 -0.9 -0.5 0.3 0.4 -0.4 0.6 -1.8 1.5 0.7 1.1 -0.5 0.5
Happiness 0.5 0.7 3.0 -0.7 0.7 0.1 0.9 1.7 0.7 0.7 0.6 0.4 -0.2 -0.4 0.6 1.2
Noisy workplace 0.2 0.2 1.1 0.0 -0.4 0.3 1.0 -0.1 -0.0 0.4 -1.1 -0.3 0.0 -0.5 -0.3 -0.4
Qualifications: A levels/AS levels or equivalent 0.5 1.1 6.3 -0.2 1.1 -0.1 -1.1 -0.6 0.9 0.0 1.1 -0.9 0.4 0.4 2.5 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.2 -0.7 -0.6 -0.1 -0.5 0.4 -0.7 -0.7 -0.5 -0.9 -0.2 1.1 -0.5 -0.5
Mouth/teeth dental problems: Dentures 1.1 1.8 6.5 2.5 0.7 1.5 1.9 -0.7 0.3 -0.8 0.3 -0.9 -1.2 -1.6 -1.2 -1.7
Asthma 1.2 2.4 10.0 -1.2 -1.7 -1.1 -0.6 -0.1 -1.8 -1.2 -3.2 0.8 0.0 -1.1 -2.5 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 4.7 -1.2 -0.8 -0.6 -0.1 -0.4 -0.4 0.3 -2.2 1.4 0.8 0.2 -0.5 0.1
Medication: Cholesterol lowering 0.6 0.9 3.7 1.2 0.6 0.5 1.0 -1.9 0.8 1.0 0.0 0.6 0.0 0.5 1.5 0.4
Depression (self-reported) 2.1 2.5 6.2 0.9 1.4 2.5 1.3 1.8 1.6 2.0 1.1 -1.7 -1.5 -1.8 1.0 0.7
Medication: Lansoprazole 1.3 1.5 5.2 0.5 -0.9 1.6 0.8 -0.1 -0.3 0.1 0.9 -1.8 -1.4 -0.5 -2.3 -1.9
Prospective memory result 1.1 1.3 7.2 -1.8 -1.7 -0.1 -0.7 0.1 -1.1 0.8 -0.7 2.7 0.1 0.3 -0.3 -0.7
Lung cancer (father) 1.3 1.5 7.0 -0.7 -1.2 0.5 -0.1 1.5 -0.8 0.8 -0.5 -0.5 -1.1 -2.6 -2.0 -1.1
Illnesses of mother 0.4 0.5 4.0 0.2 -0.4 0.1 0.9 -0.6 -0.5 -2.0 0.1 0.4 0.1 0.1 -0.3 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.7 9.7 -3.1 -2.0 -1.4 -0.8 -0.8 -2.2 -1.6 -2.7 0.2 1.1 1.3 -0.7 -0.7
Pulse wave Arterial Stiffness index 0.3 0.4 1.1 -0.2 0.4 0.5 0.3 0.7 0.7 0.8 0.5 0.5 0.4 0.5 0.7 1.1
Impedance of arm (left) 0.9 4.2 9.1 -2.0 -3.0 0.2 -0.4 -0.4 -2.5 -2.0 -2.8 2.3 -0.5 2.1 -2.0 -3.0
Arm fat mass (right) 0.3 1.2 2.9 0.7 1.4 0.3 -0.1 1.1 1.3 1.7 1.2 -0.6 0.3 -1.5 0.7 1.7
Trunk predicted mass 0.3 1.7 5.5 -1.4 -0.8 -1.6 -0.7 -2.0 -1.3 -1.1 -1.4 -1.2 2.4 0.7 -0.3 0.1
Standing height 1.0 10.1 28.3 -3.7 -3.8 -1.4 -0.7 -3.4 -3.9 -3.2 -5.3 1.2 2.2 4.2 -1.5 -2.9
Length of working week for main job 2.1 2.4 6.5 -2.5 -1.4 -1.9 -2.2 -0.4 -1.4 -0.7 -2.1 0.9 1.7 -1.3 -1.1 0.3
Exposure to tobacco smoke at home 1.4 1.6 4.6 -0.0 1.4 -0.5 0.9 1.3 1.4 2.1 1.1 -0.8 -0.2 -0.7 1.7 2.1
Breastfed as a baby 1.3 1.7 3.5 -1.3 -1.1 -1.3 -1.4 -1.1 -1.3 -1.7 -1.0 -1.9 1.5 1.6 0.5 -0.4
Tense / ‘highly strung’ 1.1 1.9 4.9 0.5 1.8 0.8 -0.3 2.2 1.6 2.0 -0.4 0.0 -0.7 -2.0 1.1 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 4.4 0.3 1.1 0.3 0.8 0.4 0.4 -1.0 -1.4 -0.6 -0.3 -2.1 -0.4 0.2
Hair/balding pattern: Pattern 4 0.2 0.5 1.5 0.0 -0.7 0.1 1.0 -0.9 -0.8 -0.3 -0.9 0.3 -0.4 1.0 -0.2 -1.2
Birth weight of first child 0.2 0.4 0.6 0.8 0.7 0.5 -0.7 0.8 0.5 0.2 0.6 -0.8 -0.5 -0.1 -0.7 -0.3
Peak expiratory flow (PEF) 3.1 7.1 20.3 -2.4 -1.6 -3.4 -1.9 -2.1 -2.5 -3.0 -4.5 2.2 2.8 3.9 -0.6 -0.5
Pulse wave reflection index 0.1 0.2 1.0 -1.0 -0.5 0.2 0.1 0.0 -0.4 0.1 -0.1 0.3 0.3 0.5 0.5 -0.2
Ever highly irritable/argumentative for 2 days 1.5 1.8 6.4 1.0 1.3 1.3 0.1 1.2 1.6 1.5 0.9 -2.5 -1.0 -1.6 1.1 0.7
Loud music exposure frequency 0.9 1.0 4.4 -0.9 -1.0 -0.9 -0.5 -0.0 -1.1 -0.9 0.1 -2.1 0.9 1.1 -0.9 -0.6
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 5.5 -0.3 1.1 -1.8 -1.5 -2.1 0.2 -1.6 0.3 -1.4 2.3 1.1 2.4 1.8
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.6 -0.5 -1.3 -0.2 0.2 0.9 -1.2 -0.9 -1.1 0.5 -1.1 1.0 -1.6 -1.0
Blood clot in the leg (DVT) 0.2 0.3 1.7 -1.0 -0.5 -0.4 -0.2 0.1 -0.4 0.3 0.2 -0.0 0.7 1.3 -0.1 0.1
Medication: Paracetamol 0.4 0.6 2.8 -1.7 -1.5 0.1 -0.0 -0.2 -0.7 0.5 -0.8 -0.1 0.2 -1.1 -0.9 -0.4
Headache pain in last month 0.4 0.7 3.5 -0.0 0.4 -0.9 0.3 -0.5 0.3 0.2 -1.4 0.7 0.9 -1.9 0.1 0.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 4.6 -1.5 -0.4 -1.0 -2.2 1.6 -0.6 -0.8 0.4 0.1 0.9 0.2 -0.4 0.5
Glaucoma (self-reported) 0.4 0.4 3.1 0.0 -0.4 -0.3 -0.2 -1.8 -0.2 -0.1 0.2 -0.6 0.4 0.8 0.8 -0.1
Gout (self-reported) 0.5 0.6 2.9 -0.2 0.5 -0.5 0.7 -1.0 0.2 -0.3 -0.4 -1.7 0.8 -0.5 1.4 0.5
Hypothyroidism/myxoedema (self-reported) 1.3 2.6 12.4 0.5 1.6 0.5 0.9 2.1 1.6 1.8 3.5 -0.9 -0.6 -1.0 1.0 1.9
Medication: Amlodipine 0.7 1.0 3.9 1.2 -0.6 1.3 0.9 -0.2 -0.4 -0.5 0.1 -0.5 -1.5 -0.7 -1.3 -2.0
Medication: Ventolin 100micrograms inhaler 3.0 3.9 10.2 -1.4 -2.2 -2.0 -0.4 -0.3 -2.6 -3.2 -3.1 0.6 1.1 0.9 -2.8 -1.6
Birth weight 0.1 0.2 0.8 -0.6 0.3 0.0 -0.3 -0.6 0.4 0.3 -0.4 -0.1 0.3 0.9 0.6 0.8
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.4 -0.4 0.2 -0.1 -0.6 0.4 0.1 0.5 -1.2 0.8 -0.3 -0.4 -0.2 0.6
High blood pressure (siblings) 0.5 0.7 2.1 0.3 0.7 1.3 0.5 1.4 0.7 1.1 0.4 0.4 -1.4 -0.7 0.1 0.1
Forced vital capacity (FVC), Best measure 0.3 1.1 4.5 -2.0 -1.4 -0.4 -0.1 -0.4 -1.4 -0.9 -2.1 -0.0 0.5 0.7 -0.5 -0.6
Body fat percentage 0.5 1.9 5.5 1.3 1.6 1.6 0.5 1.8 1.8 2.3 1.3 0.6 -1.2 -1.2 0.5 1.1
Leg fat percentage (right) 1.5 5.6 11.6 2.5 2.9 2.5 0.9 2.8 3.1 3.4 2.9 0.3 -2.1 -1.7 1.6 2.0
Arm fat-free mass (right) 0.1 0.6 2.8 -0.8 -0.3 -0.8 -0.5 -1.6 -0.6 -0.0 -0.8 -0.4 1.7 0.5 0.1 0.3
Exposure to tobacco smoke outside home 0.7 1.0 3.5 0.6 0.4 0.2 1.9 1.1 0.4 1.1 -0.7 0.8 -1.3 -1.0 -1.5 -0.1
Comparative body size at age 10 0.3 0.9 2.6 0.0 0.5 -1.0 -0.7 -0.2 0.6 0.2 1.4 -0.0 1.0 1.2 1.6 1.4
Number of full brothers 0.3 0.4 1.3 0.8 1.2 -0.3 0.5 0.3 0.6 0.2 -0.2 1.0 0.3 -0.7 -0.3 0.8
Worry too long after embarrassment 0.3 0.5 2.0 -1.3 -0.5 0.6 -0.8 -0.3 -0.4 0.3 -1.4 1.1 -0.4 0.1 0.3 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 5.6 0.0 0.1 2.0 1.8 2.0 0.4 0.3 -0.5 0.4 -2.0 -2.4 -0.9 -0.8
Wheeze or whistling in the chest in last year 0.2 0.3 0.8 -0.3 -0.5 -0.2 -0.9 -0.3 -0.5 0.2 -0.9 -0.5 -0.8 -0.8 -0.3 -0.3
Number of children fathered 1.5 1.7 6.0 2.4 0.7 1.8 1.6 1.1 0.6 -0.9 1.0 0.8 -1.5 -0.7 -1.3 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.2 0.7 0.5 -0.3 1.1 -0.5 0.3 0.4 0.1 -0.8 0.1 -0.9 0.1 0.1
Age at first live birth 1.2 2.2 6.7 -2.4 -1.3 -1.8 -0.6 -0.3 -1.7 -2.6 -1.5 -0.5 1.9 1.2 -0.6 -0.0
Pulse wave peak to peak time 0.4 0.4 1.4 -0.0 -0.6 -0.4 -0.3 -0.7 -0.9 -0.9 -0.6 -0.6 -0.4 -0.3 -0.7 -1.2
Health satisfaction 0.7 0.9 2.8 0.6 0.9 0.9 0.8 1.0 1.3 1.7 0.8 0.7 -0.4 -0.4 1.2 0.9
Shortness of breath walking on level ground 0.4 0.5 1.9 -0.1 -0.3 -1.4 -0.6 -0.1 -0.6 -1.0 0.1 -0.7 0.7 0.9 -0.9 -0.0
Qualifications: College or University degree 0.1 0.3 1.0 -0.8 0.1 -0.0 0.2 0.9 -0.0 -1.0 0.7 -0.4 -0.3 0.2 0.1 0.5
Eye problems/disorders: None of the above 0.6 0.7 1.4 -0.3 0.7 -0.7 0.9 0.5 0.4 -1.0 -1.0 0.5 0.8 1.2 0.9 1.2
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.4 1.4 -0.2 0.6 -0.7 0.2 -0.5 -0.9 -0.1 -0.5 -1.2 -1.8 -1.8 -1.7
Emphysema/chronic bronchitis 0.6 0.7 3.4 1.0 0.6 1.1 0.5 0.5 0.5 0.2 -1.2 0.4 -0.8 -1.9 0.1 0.0
Medication for pain relief, constipation, heartburn 0.3 0.5 2.7 1.0 0.6 0.2 0.7 -0.2 -0.1 -1.6 0.6 -1.3 -0.5 -0.0 -0.1 -0.5
Neck or shoulder pain in last month 1.7 2.4 6.1 2.0 1.9 1.2 0.8 0.5 2.5 2.3 0.4 -0.1 -1.0 -1.5 2.1 1.5
Medication: Blood pressure 0.5 0.8 4.8 1.3 0.4 1.2 2.2 -0.5 0.6 0.7 -0.0 0.3 -1.0 -0.3 0.4 -0.4
Angina (self-reported) 1.4 1.9 6.9 1.9 1.5 1.3 2.6 1.7 1.5 1.4 -0.1 -0.3 -1.1 -1.0 -0.4 0.3
Migraine (self-reported) 1.1 1.4 5.2 1.7 0.2 1.0 -0.4 -1.4 0.3 -0.5 2.3 -1.6 -0.4 -1.5 -0.4 -1.3
Medication: Ibuprofen 0.8 1.0 5.0 -1.4 -0.9 -0.6 -0.6 -0.0 -0.4 -0.0 -2.2 1.7 1.1 0.2 -0.6 0.4
Medication: Allopurinol 0.4 0.6 3.8 -0.4 0.8 -0.3 0.5 -0.7 0.6 0.0 0.0 0.1 0.9 0.2 1.9 1.0
Medication: Omeprazole 0.4 0.4 1.8 1.2 0.7 -0.1 -1.2 -0.3 0.4 0.3 0.2 -0.1 0.1 -1.3 -0.1 0.1
Medication: Seretide 50 evohaler 1.8 2.1 5.4 -1.3 -1.2 -2.1 0.3 -1.4 -1.6 -1.5 -2.3 -0.6 2.0 1.4 -0.7 -0.5
Mean time to correctly identify matches 1.0 2.0 4.3 -1.2 -1.2 -1.8 0.8 -1.4 -1.8 -2.1 -1.0 -1.8 1.6 0.5 -0.8 -1.2
Heart disease (mother) 1.8 2.2 7.6 0.4 1.2 0.0 1.6 1.6 1.4 2.8 2.1 -0.2 0.2 -1.2 1.2 2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 13.8 0.9 0.6 -0.7 0.1 -1.2 0.5 0.1 -0.9 3.7 0.4 1.1 1.0 0.6
Whole body fat mass 0.2 0.9 3.1 0.7 1.2 0.9 0.2 1.0 1.2 1.8 0.7 0.2 -0.3 -0.9 0.5 1.0
Leg fat mass (right) 0.6 2.3 5.5 1.6 2.1 1.4 0.5 1.4 2.1 2.3 1.5 -0.1 -0.7 -1.3 1.3 1.6
Arm predicted mass (right) 0.1 0.7 2.7 -0.9 -0.4 -0.8 -0.6 -1.6 -0.7 -0.0 -0.8 -0.4 1.6 0.4 0.2 0.2
Pulse rate, automated reading 0.7 2.2 8.2 -2.9 -2.1 -1.5 -0.6 0.2 -1.6 -0.4 -2.1 -1.1 1.4 1.3 -1.2 0.1
Alcohol intake frequency. 0.7 1.6 9.6 1.3 0.4 -0.2 -0.9 -2.4 0.0 -0.1 -0.1 -3.1 0.4 -1.8 0.2 -0.6
Comparative height size at age 10 0.2 1.2 4.6 -0.6 -1.0 0.7 0.6 -1.9 -0.9 -0.7 -1.3 -0.5 0.5 2.1 0.7 -1.3
Number of full sisters 0.5 0.6 2.4 0.1 0.0 -0.1 1.1 -1.1 0.3 1.6 1.1 -0.0 0.7 0.5 1.1 0.5
Suffer from ‘nerves’ 0.4 0.6 2.4 0.6 0.5 1.5 -0.4 1.1 0.4 0.3 0.8 1.1 -1.2 0.1 -0.3 -0.6
Overall health rating 5.4 11.6 22.6 4.5 4.4 3.1 2.4 0.7 4.8 4.7 2.7 1.1 -2.2 -3.5 4.0 2.8
Chest pain or discomfort 0.3 0.5 1.6 1.3 0.9 -0.1 0.4 -0.3 0.7 0.4 -1.0 0.1 -0.3 -1.1 -0.3 0.4
Had major operations 3.5 4.1 9.1 -2.0 -2.0 -2.8 -1.6 -2.0 -2.6 -2.3 -3.0 -0.2 1.9 1.4 -1.6 -1.4
Age at last live birth 0.9 1.3 5.2 -1.1 -1.8 -0.4 0.1 -0.5 -1.8 -2.3 0.1 -0.5 0.1 0.5 -0.9 -1.6
Family relationship satisfaction 0.2 0.2 0.6 -0.6 0.0 -0.1 -0.1 0.8 0.1 0.4 -0.4 0.3 0.4 -0.6 0.7 0.7
Leg pain on walking 0.6 0.7 2.2 -1.1 -0.8 -0.7 -1.0 -0.4 -0.8 0.1 -0.5 1.4 -0.1 -1.5 -0.5 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.7 -0.7 -0.6 -0.5 -1.3 0.4 -0.3 0.3 0.3 0.8 0.5 -1.3 0.0 0.1
Commuting to job workplace: Car/motor vehicle 2.4 2.7 6.8 2.1 2.6 1.1 0.7 0.6 2.4 1.9 1.5 1.1 -0.6 -1.1 2.2 1.7
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 0.4 -0.1 0.7 0.4 0.4 -0.2 -0.9 0.8 0.8 -0.4 0.5 -0.3 -1.0
Medication: Aspirin 0.6 0.8 5.3 0.8 0.5 -0.3 -0.4 1.0 0.6 1.3 -0.0 2.3 0.2 1.2 0.2 0.4
Supplements: Vitamin C 0.8 1.0 3.9 -1.0 -0.6 -0.9 -0.4 -0.8 -0.8 -1.4 -2.0 1.1 1.3 -0.3 -0.5 -0.1
Knee pain experienced in last month 0.4 0.6 2.1 -0.2 0.1 0.2 -0.1 1.2 0.2 0.5 1.1 -0.8 -1.4 -1.4 -0.7 0.0
Hypertension (Self-reported) 0.6 1.7 6.0 1.6 0.5 1.9 2.1 0.1 0.5 0.3 0.7 -0.1 -1.7 -2.5 0.0 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 7.4 1.8 0.3 2.1 -1.3 0.3 0.3 -0.0 1.5 -0.1 -2.7 -1.5 -1.4 -1.7
Illnesses of father: Heart disease 0.2 0.3 1.0 -0.5 -0.2 -0.3 -0.7 1.0 -0.0 0.7 -0.1 -0.7 0.1 0.5 -0.4 0.7
Illnesses of siblings: Diabetes 1.0 1.2 4.8 0.5 -0.6 2.2 1.0 -0.3 -0.4 0.1 -0.6 0.7 -1.9 -1.0 -0.6 -1.9
Smoking status: Previous 0.8 1.2 7.1 1.5 1.2 0.5 2.7 -0.2 1.2 0.6 1.3 0.2 -0.4 -0.9 0.3 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 10.4 -2.2 -1.8 -0.3 0.2 -1.1 -1.7 -0.3 -3.2 0.6 0.5 1.0 -0.2 -0.9
Whole body fat-free mass 0.3 1.6 5.5 -1.5 -0.7 -1.6 -0.7 -1.9 -1.2 -0.8 -1.4 -1.1 2.4 0.3 -0.1 0.3
Leg fat-free mass (right) 0.3 1.7 6.5 -1.7 -0.7 -1.7 -1.0 -1.7 -1.1 -0.6 -1.7 -1.1 2.5 -0.3 -0.0 0.4
Arm fat percentage (left) 0.5 2.1 5.4 1.3 1.6 1.0 -0.0 1.9 1.7 2.0 1.7 -0.3 -0.7 -2.3 0.5 1.3
Average weekly red wine intake 0.7 1.1 3.9 -0.5 -0.1 0.5 -1.4 0.8 0.2 -0.8 1.7 -1.6 -0.9 -2.0 0.5 0.2
Handedness (chirality/laterality): Left-handed 1.2 1.5 5.5 2.3 1.7 1.3 1.0 0.2 1.5 0.6 1.2 -0.7 -1.2 -0.8 1.0 0.6
Mood swings 1.0 1.8 6.0 1.0 1.0 1.7 0.4 1.2 1.2 1.7 -0.2 0.1 -2.4 -2.3 0.6 0.3
Loneliness, isolation 1.1 1.5 4.7 -0.3 1.3 0.3 -0.3 2.2 1.2 1.6 -0.2 1.9 -0.1 0.8 1.0 1.8
Long-standing illness, disability or infirmity 0.2 0.4 1.3 1.1 0.8 0.3 -0.0 -0.7 0.6 -0.1 -0.3 -0.2 -0.1 -1.1 0.6 0.2
Ever had bowel cancer screening 1.0 1.2 4.8 0.9 0.9 0.6 2.2 -1.0 0.8 0.2 2.2 0.7 -0.4 0.9 0.7 0.2
Diabetes diagnosed by doctor 0.6 1.1 3.0 1.1 1.2 1.4 -0.2 0.3 1.4 0.9 -0.0 -1.7 -0.6 -0.6 1.5 0.5
Ever had stillbirth, spontaneous miscarriage or termination 3.1 3.3 6.9 2.3 2.1 1.8 2.1 2.3 2.1 1.4 1.5 -0.0 -1.9 -2.6 0.2 0.7
Friendships satisfaction 0.6 0.8 3.3 -0.3 1.1 -1.0 -0.2 -0.1 0.8 0.7 0.1 -0.1 1.2 -0.7 1.2 1.8
Qualifications: nursing, teaching 0.8 1.2 4.0 0.8 1.3 1.2 1.3 2.0 1.6 1.0 0.0 0.0 -1.3 0.0 0.1 1.2
Commuting to job workplace: Walk 0.4 0.4 1.5 0.7 -0.2 -0.1 -1.2 -0.2 -0.3 -1.1 0.3 -1.1 -0.4 -0.1 -0.5 -0.8
Eye problems/disorders: Cataract 1.0 1.2 5.2 1.1 -0.2 1.2 -0.2 0.2 -0.0 0.1 2.3 0.3 -1.7 -1.4 -1.1 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.7 -1.3 -0.8 0.2 0.7 0.7 -0.1 1.1 -0.4 0.5 -0.7 0.9 1.0 0.3
Medication for cholesterol 2.1 3.2 8.7 -2.6 -1.8 -2.7 -1.1 -0.9 -2.1 -1.8 -1.6 0.3 1.9 2.9 -0.9 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 4.7 -0.2 1.1 1.4 0.9 0.7 1.3 1.5 0.8 -2.2 -0.7 -1.4 2.1 1.1
Back pain experienced in last month 0.5 0.7 3.8 -0.4 -0.2 0.1 -0.2 1.5 0.4 1.6 -2.0 0.3 -0.2 0.0 0.5 0.6
Mineral and other dietary supplements 1.4 1.9 9.5 -0.5 -1.8 -0.0 -0.4 -0.3 -1.8 -1.3 -0.7 0.1 -0.6 0.2 -3.1 -2.3
Breast cancer (self-reported) 0.6 0.8 3.2 1.2 0.3 0.1 0.3 -0.3 -0.1 -0.4 -0.9 -1.6 -0.5 -1.8 -0.5 -0.7
Asthma (self-reported) 1.3 2.6 11.2 -1.1 -1.8 -1.2 -0.3 -0.4 -1.9 -1.4 -3.4 1.0 0.2 -1.1 -2.5 -1.5
Osteoporosis (self-reported) 0.2 0.3 1.8 0.2 0.5 -0.1 0.0 0.2 0.6 0.9 0.3 -0.1 0.2 -0.0 1.4 0.6
Osteoarthritis (self-reported) 0.4 0.6 3.3 -0.6 -1.1 -0.4 0.3 -0.8 -0.6 -0.2 -0.0 0.1 0.8 0.2 -1.8 -0.6
Medication: Aspirin 0.5 0.6 5.0 0.8 0.6 -0.3 -0.1 0.5 0.5 0.9 -0.5 2.2 0.1 0.7 0.3 0.3
Medication: Gliclazide 0.7 0.8 1.7 1.1 0.7 1.2 1.3 0.6 1.0 0.8 0.1 -0.6 -0.9 -1.1 1.1 -0.1
Illnesses of father: None of the above (group 1) 0.4 0.4 1.6 0.6 0.3 0.7 -0.9 0.6 0.7 0.8 0.2 1.2 -0.8 -0.3 0.2 0.1
Smoking status: Current 0.6 0.9 3.7 1.1 0.7 1.9 0.3 0.9 1.0 1.1 0.1 -0.1 -1.5 -0.5 0.6 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 3.1 -1.8 -0.8 -0.8 -0.5 -0.2 -1.4 -1.4 -1.4 -0.1 0.3 -0.1 -0.8 -0.6
Whole body water mass 0.3 1.5 5.4 -1.4 -0.7 -1.6 -0.8 -1.9 -1.1 -0.7 -1.3 -1.2 2.3 0.2 -0.1 0.3
Leg predicted mass (right) 0.3 1.6 5.8 -1.6 -0.8 -1.6 -0.8 -1.7 -1.1 -0.6 -1.6 -1.1 2.4 -0.4 -0.1 0.3
Arm fat mass (left) 0.2 1.0 2.6 0.7 1.2 0.3 -0.3 1.1 1.1 1.6 1.0 -0.2 0.3 -1.6 0.5 1.4
Number of self-reported non-cancer illnesses 0.9 1.5 4.3 1.8 1.0 2.1 1.2 -0.3 1.1 1.1 1.2 0.4 -1.4 -1.6 0.4 -0.5
Average weekly champagne plus white wine intake 1.3 1.8 6.1 0.1 0.9 -1.6 -0.9 -1.0 0.9 0.5 1.9 -0.4 1.6 1.7 1.2 2.5
Miserableness 0.4 0.7 2.4 -1.0 0.4 -0.4 -0.3 0.3 0.5 1.5 -0.8 0.3 0.2 -0.7 1.2 1.6
Guilty feelings 0.7 1.1 3.5 0.1 1.0 1.1 0.7 0.4 1.0 1.8 0.1 1.9 -0.7 0.4 1.3 0.8
Wears glasses or contact lenses 0.5 0.5 2.2 1.5 0.3 0.8 1.4 0.4 0.7 0.6 -0.2 -0.6 -0.5 0.5 -0.6 -0.4
Ever taken oral contraceptive pill 0.5 0.5 2.1 -0.6 -0.0 -0.3 -0.5 -0.7 0.4 0.8 -0.5 1.5 0.1 0.6 1.1 1.0
Hearing aid user 0.8 0.9 5.5 0.4 0.0 -0.5 -0.7 -0.6 -0.1 -0.7 -0.6 -1.9 0.7 -2.3 -0.3 -0.0
Mother’s age at death 0.4 0.5 2.2 0.1 0.4 -0.3 -0.5 -1.5 0.1 -0.3 1.1 0.1 0.4 1.4 0.8 0.3
Financial situation satisfaction 1.4 1.8 6.0 -1.3 -0.3 -1.7 -0.3 -1.6 -0.3 0.1 -1.8 -0.8 2.4 -0.7 2.1 1.0
Tinnitus: Yes, now most or all of the time 0.4 0.5 3.1 0.4 0.5 0.7 0.4 1.0 0.3 -0.0 0.1 1.8 -0.3 -1.2 -0.2 0.1
Commuting to job workplace: Public transport 1.5 1.8 4.0 -2.0 -1.7 -1.7 -1.5 -0.8 -1.8 -1.4 -1.3 -0.3 1.5 1.2 -0.4 -0.4
Eye problems/disorders: Glaucoma 0.6 0.7 3.0 -0.6 -0.8 -1.0 0.2 -1.7 -0.5 0.2 -0.2 -1.1 1.2 0.7 0.7 0.3
Medication: Blood pressure 1.4 2.7 7.4 2.7 1.7 1.6 2.1 0.9 1.8 1.0 2.0 -0.6 -1.2 -2.7 -0.0 0.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.1 -0.6 -0.3 -0.3 -0.3 0.3 -0.4 -0.9 -1.4 0.4 0.2 -1.0 -1.1 -0.1
Supplements: Fish oil (including cod liver oil) 1.8 2.3 6.6 1.1 2.1 0.8 1.1 1.2 2.2 1.7 0.8 0.5 -0.4 -1.0 2.6 2.1
High cholesterol (Self-reported) 0.4 0.8 2.8 1.2 0.3 1.7 0.5 -0.1 0.7 1.3 -0.0 0.5 -1.3 -0.1 1.1 -0.6
Medication: Bendroflumethiazide 0.5 0.7 2.7 1.6 1.1 0.5 1.1 -0.1 0.9 -0.0 0.2 0.4 -0.6 -1.5 -0.4 0.2
Medication: Paracetamol 0.5 0.8 2.0 -1.3 -1.4 0.2 -1.3 -0.2 -0.8 0.0 -1.1 0.2 0.4 -1.1 -0.9 -0.7
Medication: Lisinopril 0.4 0.5 3.0 0.2 0.8 0.5 1.7 0.5 0.8 0.2 -0.5 0.3 0.3 -0.7 0.5 0.7
Medication: Atorvastatin 0.1 0.2 0.6 0.5 0.0 -0.6 -0.2 -0.6 0.1 0.4 -0.1 -0.7 -0.2 -0.0 0.8 0.1
Illnesses of father: High blood pressure 2.0 2.4 10.6 1.9 1.2 2.1 3.2 0.2 1.3 1.2 0.6 -0.6 -1.9 -1.8 0.8 -0.5
Alcohol drinker status: Never 1.0 1.2 5.9 -0.3 -0.4 0.4 -0.1 0.1 -0.4 0.6 1.3 -2.3 -0.6 -2.4 -0.8 -0.6
Ever smoked 0.7 1.2 4.3 1.8 0.2 0.7 1.6 -0.6 0.1 -1.3 2.1 -0.8 -0.7 -0.4 -0.9 -0.9
Basal metabolic rate 0.2 0.9 4.2 -1.2 -0.4 -1.2 -0.7 -1.4 -0.8 -0.3 -1.1 -0.9 2.0 0.0 0.0 0.5
Leg fat percentage (left) 1.5 5.5 10.9 2.6 3.1 2.4 1.1 2.6 3.2 3.3 2.6 0.7 -2.0 -1.7 1.5 2.0
Arm fat-free mass (left) 0.2 0.8 4.1 -0.9 0.1 -1.2 -0.3 -1.5 -0.3 0.1 -0.5 -0.5 2.0 0.5 0.4 1.0
Number of operations (self-reported) 0.8 1.2 2.2 -0.7 -1.3 -1.3 0.8 -1.4 -1.4 -1.5 -1.1 0.0 0.9 0.2 -1.2 -1.3
Average weekly beer plus cider intake 1.4 2.0 5.4 2.1 0.1 1.8 -0.4 0.7 -0.1 -0.5 -1.1 -0.7 -2.0 -1.2 -2.3 -2.1
Irritability 0.5 0.8 3.6 -0.6 -0.3 -1.1 -1.9 -1.1 -0.5 -0.9 0.0 -0.2 1.2 1.0 0.3 0.1
Risk taking 0.2 0.3 2.0 0.8 0.3 -0.4 0.1 -0.5 0.0 -0.7 -0.5 -1.4 0.3 -0.2 -0.2 0.2
Ever had prostate specific antigen (PSA) test 1.4 1.7 5.7 1.5 0.9 0.8 1.8 1.6 0.7 -0.3 1.1 -1.6 -2.4 -1.0 -0.8 -0.4
Fractured/broken bones in last 5 years 0.6 0.8 4.2 0.7 0.7 0.3 -0.2 -0.9 0.6 0.4 0.9 -2.0 0.3 -1.6 0.9 0.3
Age started oral contraceptive pill 0.7 0.9 3.4 -0.2 0.1 -0.9 -1.2 -0.3 0.3 0.1 1.9 -0.7 1.3 1.4 0.7 0.8
Diastolic blood pressure, automated reading 0.2 0.8 2.5 0.6 1.0 0.6 0.2 1.6 0.6 0.3 1.6 0.6 -0.1 -1.4 0.3 0.6
Ever depressed for a whole week 0.2 0.2 0.6 -0.3 0.0 -0.3 -0.8 -0.4 0.1 -0.4 0.8 0.3 0.4 -0.4 0.5 0.2
Unable to work because of sickness or disability 0.4 0.6 2.0 0.6 0.2 0.9 -0.6 -1.0 0.5 0.8 -1.1 0.3 0.4 -1.4 0.8 -0.2
Commuting to job workplace: Cycle 2.3 2.8 9.7 -3.1 -2.4 -1.7 -1.2 -0.5 -2.1 -1.1 -1.6 -0.4 1.9 1.5 -1.3 -0.5
Myopia 1.2 1.7 6.2 -0.2 -1.2 1.4 2.5 0.5 -0.8 -0.9 0.3 -2.0 -1.8 0.5 -1.0 -1.6
Vascular/heart problems diagnosed by doctor 0.7 2.0 4.9 -2.2 -1.1 -2.0 -2.1 -0.1 -1.0 -0.7 -1.5 -0.3 1.6 2.1 -0.3 0.7
Cholesterol lowering medication 0.3 0.5 1.7 0.5 -0.2 0.9 0.2 0.1 -0.1 0.3 -0.7 -1.3 -0.6 -0.9 -0.3 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 3.1 1.8 1.2 0.7 -0.3 -0.2 1.1 0.5 0.5 -0.3 -0.5 -1.6 0.2 0.4
Pain experienced in last month 1.6 2.6 8.8 -0.5 -1.2 -1.3 -1.2 -2.2 -2.0 -3.0 1.3 -1.3 1.1 2.0 -1.1 -1.5
Supplements: Calcium 2.1 2.3 5.9 -2.4 -1.8 -1.7 -1.0 -0.7 -1.6 -1.2 -2.0 -0.4 2.1 2.1 0.8 0.0
Basal cell carcinoma (self-reported) 0.3 0.3 1.1 -0.0 0.6 -0.5 -0.2 -0.4 0.7 0.7 -1.0 0.4 0.6 -0.1 0.4 1.0
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.2 0.3 -0.7 1.3 1.8 -0.9 -0.3 0.5 -0.3 1.4 -1.2 -0.6 -0.7 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.5 -0.9 -0.7 -0.6 -0.4 0.1 -0.6 0.0 0.4 0.0 0.8 1.2 -0.3 -0.2
Heart disease (siblings) 2.5 3.0 8.0 2.6 2.4 1.8 0.9 0.5 2.4 1.2 2.8 -1.0 -1.5 -1.5 1.0 1.0
Alcohol drinker status: Previous 2.2 2.5 8.5 1.9 0.9 1.9 -1.0 -0.2 1.1 1.0 2.9 -2.7 -0.7 -1.9 1.1 -0.6
Pack years of smoking 0.9 1.3 2.8 1.7 0.6 1.5 0.4 0.5 1.0 0.8 1.5 -1.5 -1.4 -1.4 0.4 -0.3
Impedance of whole body 0.7 3.6 10.3 -1.2 -2.3 1.3 0.5 -0.1 -1.6 -1.0 -2.4 3.2 -1.6 2.6 -1.5 -2.7
Leg fat mass (left) 0.6 2.4 5.5 1.7 2.2 1.4 0.6 1.4 2.1 2.3 1.4 0.1 -0.6 -1.4 1.3 1.7
Arm predicted mass (left) 0.1 0.7 3.6 -0.8 0.0 -1.1 -0.3 -1.4 -0.4 -0.0 -0.4 -0.5 1.9 0.1 0.2 0.9