Hub : Genes

CDS2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2250 0.0390 1.3e-13 0.153 0.137 0.210 0.197 0.215 3.1e-18 2.1e-16 4.3e-25 2.0e-23 1.0e-25
2 GTEx Artery Coronary 0.2690 0.0950 3.9e-03 0.012 NA 0.009 NA 0.008 1.2e-01 NA 1.5e-01 NA 1.7e-01
3 GTEx Brain Cerebellum 0.2640 0.0850 3.2e-03 0.272 NA 0.205 NA 0.133 1.2e-08 NA 1.1e-06 NA 9.5e-05
4 GTEx Brain Putamen basal ganglia 0.4310 0.1330 6.5e-03 0.160 NA 0.054 NA 0.118 1.3e-04 NA 2.1e-02 NA 9.8e-04
5 GTEx Cells EBV-transformed lymphocytes 0.2670 0.0920 6.3e-03 0.183 NA 0.196 NA 0.187 1.4e-06 NA 5.4e-07 NA 1.0e-06
6 GTEx Cells Transformed fibroblasts 0.1490 0.0550 6.5e-03 0.034 NA 0.069 NA 0.042 1.3e-03 NA 6.6e-06 NA 3.8e-04
7 GTEx Whole Blood 0.1390 0.0360 1.8e-05 0.138 NA 0.097 NA 0.125 1.0e-12 NA 3.0e-09 NA 1.5e-11
8 NTR Blood 0.0967 0.0159 0.0e+00 0.129 0.080 0.124 0.127 0.129 2.4e-39 1.7e-24 9.7e-38 6.3e-39 2.4e-39
9 ROSMAP Brain Pre-frontal Cortex 0.1144 0.0303 1.8e-05 0.087 0.028 0.043 0.064 0.074 2.8e-11 1.2e-04 3.0e-06 1.0e-08 7.8e-10
10 YFS Blood 0.3506 0.0264 0.0e+00 0.532 0.494 0.533 0.501 0.536 1.4e-210 6.2e-189 9.2e-211 1.0e-192 8.9e-213
11 TCGA Esophageal Carcinoma 0.2090 0.0980 5.4e-03 0.025 0.095 0.042 NA 0.014 5.3e-02 6.3e-04 1.8e-02 NA 1.1e-01
12 TCGA Kidney Renal Papillary Cell Carcinoma 0.0570 0.0310 8.4e-03 0.002 0.034 0.018 NA 0.009 2.3e-01 4.7e-03 3.2e-02 NA 8.8e-02
13 TCGA Lung Adenocarcinoma 0.0321 0.0168 9.2e-04 0.032 0.014 0.021 NA 0.022 1.2e-04 8.9e-03 1.3e-03 NA 1.2e-03
14 TCGA Pancreatic Adenocarcinoma 0.0660 0.0380 6.8e-03 0.028 0.021 -0.006 NA 0.013 2.3e-02 4.4e-02 6.8e-01 NA 8.6e-02
15 TCGA Prostate Adenocarcinoma 0.0282 0.0157 5.3e-03 0.010 0.009 0.020 NA 0.015 3.1e-02 3.6e-02 2.8e-03 NA 9.2e-03
16 TCGA Thyroid Carcinoma 0.0750 0.0340 6.9e-06 0.042 0.043 0.031 NA 0.050 5.9e-05 5.1e-05 4.6e-04 NA 1.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.5 0.7 2.7 1.0 -0.8 0.5 1.3 1.1 1.6 -0.5 -0.6 1.5 -0.6 -0.1 -0.5 -0.2 -0.4 -0.3 -0.7
Bipolar Disorder or Schizophrenia 0.7 1.6 5.1 -1.2 0.0 -1.5 -1.5 -1.1 0.4 1.4 1.2 -0.1 1.3 0.8 1.0 2.2 1.8 1.1 1.5
Depressed Affect (Nagel 2018) 0.2 0.3 1.1 1.0 -0.9 0.6 -0.1 0.5 0.2 -0.1 -0.1 0.9 -0.2 -0.4 -0.1 -0.7 -1.0 -0.5 -0.1
Depression (Nagel 2018) 1.5 2.3 4.9 0.9 0.3 1.9 1.1 2.2 -0.6 -1.7 -1.6 0.2 -1.7 -0.5 -1.8 -2.1 -1.6 -1.9 -1.7
Intelligence (Savage-Jansen 2018) 1.2 3.7 11.2 1.3 -0.5 1.8 2.7 1.4 0.2 -1.8 -1.8 -0.2 -1.9 -2.8 -1.8 -2.3 -2.1 -3.4 -2.0
Neuroticism (Nagel 2018) 0.6 1.3 3.9 1.9 -0.4 1.4 0.8 1.3 0.5 -0.5 -0.4 2.0 -0.6 -1.0 -0.6 -1.5 -1.8 -1.3 -0.6
Schizophrenia (2018) 1.9 3.9 9.3 -2.3 0.9 -2.3 -3.0 -2.3 -0.7 2.2 2.0 -1.3 2.1 1.1 1.7 3.1 2.6 1.5 0.0
Schizophrenia vs Biploar Disorder 2.1 2.8 9.2 -1.8 -0.5 -1.6 -3.0 -2.3 -1.2 1.6 1.8 -1.6 1.8 0.7 1.0 1.4 1.9 1.2 1.8
Worry (Nagel 2018) 0.4 0.7 2.7 1.4 -0.4 1.0 1.1 1.1 0.8 -0.6 -0.4 1.6 -0.5 0.0 -0.4 -0.8 -1.1 -0.4 -0.5
Alzheimer’s Disease (in mother) 0.5 0.5 5.1 0.7 -0.5 0.3 -0.4 0.4 2.3 -0.5 -0.5 1.2 -0.4 0.1 0.3 0.2 -0.3 0.2 -0.4
Alzheimer’s Disease (in father) 0.3 0.3 1.3 0.1 -0.5 0.2 -0.1 -0.5 -0.2 0.3 0.7 -0.7 0.4 -1.2 -0.5 -0.9 -0.2 -0.7 0.0
Alzheimer’s Disease (including proxy) 1.2 1.8 4.4 1.7 -0.8 1.6 1.2 1.3 2.1 -1.6 -1.2 0.6 -1.3 -0.8 -0.6 -1.4 -1.6 -1.0 -1.6
Crohns Disease (2017) 0.3 0.6 2.1 0.3 0.8 -0.1 -1.0 -0.2 0.1 0.4 0.2 0.5 0.3 1.4 -1.1 -0.0 1.1 1.4 0.6
Irritable Bowel Disease (IBD) 0.1 0.3 1.3 0.1 1.1 -0.0 -0.7 -0.2 -0.5 0.6 0.5 -0.0 0.4 0.1 -1.1 -0.3 0.7 0.5 0.6
Ulcerative Colitis (UC) 0.3 0.5 2.0 -0.5 1.1 -0.2 -0.0 -0.4 -1.0 0.6 0.7 -0.8 0.5 -1.4 -0.6 -0.5 0.2 -0.7 0.3
Major Depression (MDD) 0.4 0.5 3.1 -0.6 1.2 -0.2 0.2 -0.2 -0.7 0.2 0.4 -0.3 0.3 1.2 1.8 0.6 -0.5 0.5 0.2
Reaction Time 0.2 0.4 1.9 0.2 1.4 0.5 0.9 1.0 -0.6 -0.4 -0.1 0.1 -0.2 0.5 -0.7 -0.5 -0.1 -0.4 -0.4
Verbal and Numeric Reasoning (VNR) 0.9 2.1 10.9 0.2 -0.5 0.9 1.0 0.3 -0.6 -0.7 -0.8 -1.0 -1.0 -3.3 -1.3 -1.9 -1.3 -3.1 -1.1
Breast Cancer 0.2 0.4 2.8 -0.7 0.3 0.2 -0.2 0.3 0.2 0.0 0.1 -1.4 -0.0 1.7 -0.8 0.4 0.7 0.3 -0.1
Ovarian Cancer 0.1 0.2 0.6 0.1 -0.5 -0.3 0.5 -0.3 -0.1 -0.3 -0.4 -0.1 -0.3 -0.7 -0.3 -0.1 0.3 -0.8 -0.3
Prostate Cancer 0.1 0.1 0.7 0.1 0.1 -0.3 0.3 -0.7 -0.2 0.2 -0.0 -0.4 0.1 0.2 0.8 0.5 -0.1 0.1 0.3
Age at First Birth 0.2 0.3 1.4 0.2 -0.6 -0.2 -0.4 -0.1 0.3 -0.1 0.1 0.9 0.2 0.6 0.8 0.2 0.0 1.2 0.0
Bipolar Disorder (2011) 0.3 0.3 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.4 -1.4 -1.2 -0.8 -0.7 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 2.2 -0.9 0.6 0.3 0.1 0.2 1.0 -0.5 -0.5 -0.6 -0.4 1.5 -0.4 0.4 0.5 0.3 0.0
Coronary Artery Disease (CAD) 0.2 0.2 1.6 0.6 0.8 0.6 0.6 0.3 -0.4 -0.1 -0.2 0.1 -0.3 0.4 -1.3 0.2 0.1 -0.2 0.0
Crohns Disease (2012) 0.4 0.6 2.2 0.8 0.6 0.7 0.4 0.9 0.5 -0.6 -0.8 1.4 -0.7 1.5 -0.5 -0.5 -0.1 1.0 -0.3
Mean Putamen Volume 1.7 1.9 4.9 -1.7 0.0 -1.7 -1.5 -1.8 -0.5 1.8 1.7 -0.9 1.7 0.3 2.2 1.9 1.1 0.8 0.0
Fasting Glucose 0.5 0.6 1.6 0.5 -1.1 0.5 0.9 0.9 1.0 -0.9 -1.0 0.8 -0.8 1.3 -0.5 0.2 -0.2 0.3 -0.6
HbA1C 0.5 0.6 4.4 0.4 2.1 0.6 0.4 0.2 -0.1 -0.6 -0.8 0.3 -0.8 -0.0 0.4 0.1 -1.1 -1.0 -0.5
HDL Cholesterol 0.2 0.4 1.7 0.1 1.3 -0.4 -1.0 -0.5 -0.3 0.4 0.6 0.2 0.5 -1.0 -0.5 -0.3 0.5 -0.4 0.0
LDL Cholesterol 0.3 0.4 1.5 0.6 -0.8 -0.5 0.5 0.2 0.7 0.3 0.7 1.2 0.6 0.3 1.0 0.9 0.0 0.5 0.0
Lupus 0.5 0.7 2.4 0.2 -0.1 -0.2 -0.3 -0.3 0.8 1.2 1.1 0.4 1.0 0.2 -1.1 0.5 1.1 1.6 1.2
Neuroticism (2016) 0.5 0.7 2.8 1.7 0.3 0.8 0.1 0.8 1.5 -0.4 -0.1 1.5 -0.4 -0.7 -0.2 -0.3 -1.1 -0.7 0.0
Primary Biliary Cirrhosis 0.5 0.7 1.9 0.5 -1.1 1.2 0.7 1.4 1.3 -0.6 -1.0 0.7 -0.9 0.9 -0.4 -0.3 -0.9 0.5 0.0
Rheumatoid Arthritis 0.6 0.8 1.6 -1.1 -0.6 -0.9 -0.4 -1.3 -0.8 0.7 0.9 -0.8 0.9 1.1 1.0 0.7 0.8 0.8 0.7
Schizophrenia (2014) 0.8 1.8 4.9 -1.6 1.0 -1.4 -1.6 -1.2 0.1 1.0 0.9 -0.7 1.1 1.5 1.1 2.2 1.9 1.5 1.2
Triglycerides 0.2 0.3 0.9 0.5 -1.0 0.5 0.9 0.8 0.1 -0.6 -0.2 0.8 -0.3 0.9 -0.0 0.0 -0.5 0.1 0.0
Type 2 Diabetes (T2D) (2012) 0.9 1.0 4.5 1.0 2.1 0.7 0.9 0.1 2.1 -0.7 -1.3 0.9 -1.1 0.5 -0.9 -0.3 -0.3 0.0 0.0
Ulcerative Colitis 0.6 0.9 1.9 0.7 -0.1 1.2 0.5 1.0 -0.8 -0.9 -0.8 0.5 -1.0 -0.6 -0.7 -1.4 -1.3 -1.2 -1.1
Blood Eosinophil Count 0.4 3.1 7.2 -1.2 0.1 -1.8 -2.1 -2.7 -0.2 2.2 2.3 -2.0 2.2 -0.3 1.4 2.0 1.7 1.3 2.0
Blood Platelet Count 0.1 1.2 2.3 -0.1 1.0 -1.2 -1.2 -0.4 1.5 1.3 1.2 1.1 1.2 -1.2 1.1 1.1 0.7 1.1 1.4
Blood Red Count 0.1 0.8 2.6 -0.7 0.1 -1.1 -0.2 -1.5 -1.6 0.9 0.8 0.1 0.8 0.3 0.1 1.0 1.2 -0.7 0.7
Blood White Count 0.0 0.3 1.7 0.4 -0.7 0.3 0.1 0.9 -1.3 0.3 0.3 -0.7 0.2 -0.0 0.6 -0.1 -0.8 0.2 0.2
Heel T-Score 0.9 7.3 19.2 -4.4 -1.2 -3.1 -3.1 -3.7 -2.4 2.5 2.5 -3.1 2.6 0.9 2.7 2.1 2.8 1.8 2.2
BMI 0.2 1.3 9.1 0.9 -3.0 1.1 0.7 1.1 0.8 -1.3 -1.0 0.7 -1.1 -0.0 -0.5 -0.5 -1.1 -0.7 -1.2
Height 0.2 3.4 35.0 -1.7 -0.2 0.1 0.3 -1.0 -5.9 -0.4 -0.5 -2.1 -0.4 3.0 1.1 0.0 -0.3 0.2 -0.3
Waist Hip Ratio (WHR) 1.0 4.5 7.1 2.2 -0.1 2.5 2.4 2.2 -1.0 -2.4 -2.5 1.7 -2.6 -0.7 -1.6 -2.4 -2.5 -2.7 -2.4
Systolic Blood Pressure 0.0 0.2 0.8 -0.5 0.2 -0.7 -0.1 -0.3 -0.9 -0.0 -0.0 -0.9 0.1 -0.4 0.6 0.3 0.3 -0.5 0.0
Smoking Status 0.2 0.5 2.1 -1.2 0.8 -0.3 -0.7 -0.4 -0.4 0.6 0.5 -1.5 0.5 -0.5 0.6 0.4 0.3 0.3 0.5
Allergy or Eczema 0.2 0.5 2.3 0.6 0.1 0.8 0.8 0.4 -0.5 -0.2 -0.0 1.5 -0.3 -0.6 0.4 -0.5 -1.2 -1.1 -0.3
Cardiovascular Disease 0.5 1.6 4.9 1.0 -0.5 1.7 2.2 1.8 1.5 -1.2 -1.0 0.8 -1.2 0.2 -1.4 -0.9 -1.3 -1.2 -1.3
Hypothyroidism (self reported) 0.1 0.2 1.5 -0.1 -0.6 -0.1 -1.2 -0.6 0.7 0.3 0.3 -0.0 0.2 -0.1 -0.1 0.2 -0.0 0.1 0.1
Respiratory disease 0.8 1.8 3.7 -0.6 0.5 -1.4 -1.6 -1.5 -0.4 1.6 1.4 0.0 1.5 1.1 1.4 1.8 1.4 1.9 1.7
Type 2 Diabetes (T2D) (2018) 1.6 3.0 8.6 1.2 -0.6 2.2 2.9 1.8 0.4 -1.8 -1.6 1.5 -1.8 0.1 -1.5 -2.1 -2.0 -1.9 -2.0
Lung FEV1/FVC ratio 0.1 0.7 1.4 0.3 -0.5 0.9 0.2 0.6 -0.5 -1.1 -0.9 0.7 -0.9 -0.5 -1.2 -1.0 -0.7 -1.2 -1.0
Lung FVC 0.1 0.5 2.9 0.1 1.7 -0.6 -1.0 -0.5 0.2 0.5 0.5 1.0 0.6 0.9 -0.1 -0.0 0.9 0.8 0.5
Neuroticism 0.0 0.1 0.3 0.2 0.1 0.0 -0.3 0.2 -0.3 0.4 0.4 0.6 0.3 0.0 0.1 -0.1 -0.2 -0.3 0.3
Chronotype (morning person) 0.3 0.6 1.9 -0.7 -0.8 -0.9 -0.3 -1.0 0.6 0.8 0.8 0.1 0.8 0.2 1.4 1.4 0.5 0.1 0.9
Hair Pigment 0.0 0.2 0.9 -0.5 -0.8 0.1 -0.3 0.3 -1.0 -0.1 -0.2 -0.5 -0.2 0.5 0.1 0.4 -0.0 -0.4 -0.0
Tanning 0.1 0.9 2.4 -0.2 1.4 -0.6 -0.2 -0.7 -0.4 1.5 1.4 -0.6 1.3 -0.4 0.6 0.3 0.4 1.6 1.5
Hand grip strength (left) 0.2 0.5 2.2 -0.6 -1.5 -0.6 -0.8 -0.9 -0.5 0.3 0.1 -1.2 0.2 -0.5 1.1 0.1 -0.1 0.4 0.2
Number of treatments/medications taken 0.1 0.2 1.6 -0.0 -1.3 0.1 -0.5 0.0 -0.7 0.4 0.6 -0.0 0.4 0.6 -0.0 -0.0 0.0 0.5 0.4
Average weekly spirits intake 1.1 1.4 2.9 0.6 -1.2 1.7 0.8 1.5 -0.5 -1.4 -1.5 -0.1 -1.5 1.1 -0.7 -1.3 -1.5 -0.6 -1.2
Sensitivity / hurt feelings 0.2 0.3 1.8 0.2 0.2 -0.0 -0.6 -0.2 -0.1 0.5 0.8 -0.1 0.5 -1.4 0.0 -0.1 -0.2 -1.3 0.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.7 -0.1 0.6 0.7 1.1 1.3 0.1 -0.4 -0.3 -0.3 -0.5 0.1 -1.1 -0.8 -0.1 -0.8 -0.5
Hearing difficulty/problems: Yes 0.3 0.5 3.2 -1.0 -0.3 0.5 0.4 0.9 -0.6 -0.5 -0.4 -1.2 -0.5 1.8 -0.2 0.4 0.1 -0.1 -0.3
Relative age of first facial hair 2.7 5.5 12.2 -1.6 1.0 -2.5 -3.5 -3.3 -0.2 2.9 2.9 -0.9 2.8 -0.5 2.7 2.6 1.8 1.7 2.9
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 5.7 0.7 -1.5 0.8 0.2 0.3 -2.4 -0.4 -0.4 0.4 -0.5 -0.6 -0.0 -0.9 -1.3 -0.3 -0.5
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.7 0.7 -0.5 0.6 0.5 0.9 -0.2 -0.5 -0.4 -0.5 -0.5 -0.1 -0.6 -0.4 -0.7 -0.7 -0.6
Ever had hysterectomy (womb removed) 0.2 0.3 0.7 0.4 -0.2 0.3 0.2 0.8 -0.6 -0.5 -0.6 0.8 -0.6 -0.5 -0.4 -0.1 -0.3 -0.8 -0.6
Systolic blood pressure, automated reading 0.6 1.8 3.1 1.3 -1.2 1.4 1.6 1.1 -1.2 -1.3 -1.3 0.5 -1.3 -1.3 -1.3 -1.8 -1.5 -1.7 -1.3
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.8 -1.2 -0.6 -0.0 0.4 -0.0 -0.1 -0.0 0.2 -0.2 0.2 1.3 -0.1 0.2 0.8 0.3 0.0
Angina 0.9 1.2 3.2 -1.0 -1.5 -1.1 -1.0 -0.8 -0.2 1.2 1.5 -0.8 1.4 0.2 1.0 1.8 1.1 0.6 1.3
Medication for hormone replacement therapy 0.8 0.9 3.9 1.3 -2.0 0.7 0.5 0.6 0.8 -0.8 -0.6 1.1 -0.6 -1.0 -0.3 -1.1 -1.0 -0.4 -0.9
Vitamin and mineral supplements 2.3 3.1 6.6 -1.3 1.7 -2.1 -2.6 -2.3 -0.4 1.8 1.8 -1.2 1.8 -2.5 2.0 1.4 1.1 -0.4 1.8
Supplements: Zinc 0.3 0.4 1.8 -0.4 -0.7 -0.4 -0.6 -0.8 -1.3 0.7 0.7 -0.2 0.6 0.4 -0.1 0.1 0.6 0.2 0.6
Medication: Co-codamol 0.1 0.2 0.7 0.0 -0.5 -0.3 0.1 -0.8 0.2 0.5 0.3 0.8 0.3 0.1 -0.2 0.1 0.4 0.3 0.4
Medication: Metformin 0.7 1.0 5.3 0.0 -1.1 1.1 2.3 0.6 -0.5 -0.6 -0.4 -0.3 -0.6 -0.5 -1.0 -1.6 -0.9 -1.2 -0.9
Diabetes (father) 0.2 0.2 1.6 -0.0 0.5 -0.3 -0.5 -0.3 1.3 0.0 0.3 0.2 0.3 -0.5 0.7 -0.2 -0.2 0.1 -0.3
Diabetes (mother) 0.3 0.4 2.0 0.4 -1.4 0.9 0.2 0.3 -0.1 -0.5 -0.5 0.3 -0.6 -0.2 -0.0 -0.7 -1.2 -0.7 -0.5
Severe depression (siblings) 2.9 3.2 5.5 -2.0 -0.1 -2.4 -1.3 -1.9 0.6 2.0 2.2 -2.3 2.2 -1.5 2.1 2.0 1.3 0.5 1.9
Pack years adult smoking proportion 0.7 1.1 2.9 -0.5 -0.2 -0.8 -0.7 -1.0 0.0 1.6 1.7 -1.0 1.5 -0.5 1.0 0.6 0.5 1.4 1.4
Impedance of leg (right) 0.4 1.8 22.1 -0.0 4.7 -0.2 0.2 0.3 0.3 0.9 0.6 0.2 0.6 1.1 -1.0 0.4 1.2 1.0 0.9
Leg fat-free mass (left) 0.3 1.3 10.8 -0.2 -3.3 0.3 0.1 -0.4 -2.0 -0.7 -0.5 -1.0 -0.5 0.0 1.2 -0.4 -1.3 -0.7 -0.7
Trunk fat percentage 0.1 0.5 2.8 0.4 -1.4 0.2 0.4 -0.1 -1.7 -0.3 0.1 -0.7 -0.1 0.3 -1.4 -0.3 0.4 -0.2 -0.4
Hand grip strength (right) 0.3 0.8 3.7 -1.1 -1.2 -0.7 -1.2 -0.8 -0.5 0.4 0.1 -1.9 0.2 -0.7 1.4 0.3 -0.2 -0.1 0.3
Townsend deprivation index at recruitment 0.3 0.4 1.5 0.8 -1.2 0.4 -0.1 0.4 -0.4 0.3 0.3 0.6 0.2 0.0 1.1 -0.3 -1.2 0.7 0.1
Current tobacco smoking 1.1 1.8 3.4 -1.8 0.3 -1.5 -1.5 -1.4 -0.9 1.6 1.6 -1.8 1.6 -0.4 1.5 1.1 1.0 1.0 1.4
Average weekly fortified wine intake 0.3 0.3 1.6 0.2 0.4 -0.0 -0.0 -0.5 0.6 -0.5 -0.8 -0.3 -0.6 -1.1 0.0 0.1 -0.5 -1.3 -0.4
Maternal smoking around birth 0.4 0.6 1.9 -1.0 -0.8 -0.5 -0.2 -0.6 -1.4 0.7 0.9 -1.0 0.7 -0.1 1.1 0.8 -0.0 -0.3 0.6
Fed-up feelings 0.3 0.5 3.0 0.3 -1.7 -0.4 0.7 -0.2 1.0 0.8 0.8 0.4 0.7 -0.0 0.3 0.8 0.3 0.1 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 3.5 -0.2 0.1 0.4 0.9 1.0 -0.1 -0.5 -0.5 -0.9 -0.6 -1.5 -0.6 -0.8 -0.5 -1.9 -0.6
Relative age voice broke 3.1 4.7 9.8 -1.3 1.2 -2.6 -3.1 -3.0 0.7 2.6 2.7 -0.3 2.6 -1.4 2.6 2.2 1.7 1.3 2.6
Taking other prescription medications 0.2 0.3 1.7 0.9 -1.3 0.8 -0.3 0.2 -0.5 -0.1 -0.1 -0.0 -0.2 0.1 -0.5 -0.5 -0.7 0.3 -0.2
Age when periods started (menarche) 0.4 0.9 2.8 -0.5 1.7 -1.3 -1.1 -1.1 -0.9 1.0 0.9 0.4 1.0 -0.4 0.1 0.7 1.3 0.5 0.9
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 4.5 0.4 -1.1 0.7 0.2 0.7 -0.6 -0.9 -1.0 1.2 -0.9 2.1 -0.9 -0.1 0.1 -0.3 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 4.6 -2.1 -1.5 -2.0 -1.9 -2.1 -1.7 1.2 1.2 -1.3 1.4 0.1 1.8 1.4 1.5 0.5 1.2
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.0 -1.2 0.5 -1.1 -1.4 -1.2 -0.2 0.8 0.8 -1.2 0.9 -0.4 0.7 0.7 0.9 0.2 0.8
Qualifications: CSEs or equivalent 0.5 0.7 4.1 -1.1 -2.0 -0.4 -0.6 -0.5 0.0 0.9 0.9 -0.8 0.8 0.5 0.1 0.3 0.7 0.9 0.7
Serious illness, injury or assault to yourself 1.1 1.4 2.7 -1.4 0.5 -1.5 -1.2 -1.5 -0.9 1.1 1.2 -1.5 1.3 -1.0 1.7 1.2 0.7 0.1 0.9
High blood pressure 0.7 1.9 3.5 0.5 -0.5 1.6 1.7 1.5 1.2 -1.9 -1.7 0.5 -1.7 -0.1 -1.4 -1.1 -1.1 -1.8 -1.8
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.7 0.7 -0.5 0.3 0.9 0.1 0.2 0.0 0.2 1.7 -0.0 -1.2 1.0 -0.2 -1.2 -1.2 0.1
Multivitamins +/- minerals 1.2 1.6 6.6 0.1 -2.2 1.2 1.5 1.5 1.3 -0.8 -0.9 -0.1 -0.9 2.6 -1.4 -0.4 -0.1 1.0 -0.8
Stomach or abdominal pain in last month 2.0 2.5 5.4 -1.4 -1.1 -1.8 -1.3 -1.8 -0.9 2.1 2.3 -1.2 2.2 -1.1 1.7 1.4 1.0 0.8 1.8
Supplements: Glucosamine 0.4 0.5 2.6 0.8 -0.1 0.7 0.2 0.4 -0.3 -0.7 -0.8 1.6 -0.8 0.6 -0.2 -0.6 -0.9 0.1 -0.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 -0.3 0.6 -0.2 -0.5 -0.2 0.1 0.4 0.5 -0.2 0.4 0.4 -0.5 0.5 0.8 -0.2 0.5
Medication: Atenolol 0.2 0.2 0.9 0.0 -0.2 -0.2 -0.4 0.2 -0.4 0.4 0.5 -0.5 0.4 0.7 0.3 0.8 0.3 1.0 0.7
Medication: Levothyroxine sodium 0.4 0.6 5.4 0.1 -0.8 0.1 -0.4 0.0 1.0 0.1 0.1 0.8 0.1 2.3 -0.4 0.8 0.7 1.0 0.0
Sitting height 0.1 0.7 2.3 -0.3 1.4 -0.4 0.4 -1.0 -1.5 -0.1 -0.1 -1.0 -0.1 -0.8 1.5 -0.2 -0.9 -0.8 -0.2
Chronic bronchitis/emphysema (father) 0.9 1.0 4.0 -1.6 -0.4 -1.1 0.2 -0.5 -0.2 0.6 0.2 -1.5 0.4 1.2 1.1 2.0 1.2 0.3 0.8
High blood pressure (mother) 0.2 0.3 1.1 -0.8 -0.5 -0.2 0.1 -0.6 1.0 0.3 0.2 -0.8 0.2 -0.6 1.0 0.6 -0.1 -0.2 0.4
Body mass index (BMI) 0.3 1.2 10.8 0.3 -3.3 0.8 0.4 0.3 -0.8 -0.9 -0.5 -0.8 -0.7 -0.6 -1.2 -0.8 -0.6 -1.2 -1.0
Impedance of leg (left) 0.4 1.9 22.6 0.2 4.8 -0.1 0.2 0.3 0.4 0.7 0.5 0.4 0.5 0.9 -1.3 0.1 1.2 0.9 0.7
Leg predicted mass (left) 0.3 1.3 11.1 -0.3 -3.3 0.2 0.1 -0.4 -2.0 -0.7 -0.4 -1.1 -0.5 0.1 1.2 -0.3 -1.2 -0.7 -0.7
Trunk fat mass 0.2 0.9 4.3 0.5 -2.0 0.6 0.7 0.1 -2.1 -0.7 -0.4 -0.6 -0.5 0.2 -1.2 -0.7 -0.3 -0.7 -0.9
Waist circumference 0.7 2.4 3.8 1.6 -1.9 1.8 1.9 1.1 -1.1 -1.8 -1.4 0.3 -1.6 -0.7 -1.5 -1.8 -1.9 -1.7 -1.9
Number of incorrect matches in round 0.3 0.5 1.3 0.9 -0.6 1.0 0.2 0.9 -0.1 -0.4 -0.1 0.9 -0.3 1.1 -0.5 -0.8 -0.9 0.6 -0.3
Past tobacco smoking 0.6 1.1 3.0 -0.6 -0.2 -1.3 -0.9 -0.8 -0.7 1.2 1.2 0.3 1.3 1.3 0.2 1.1 1.7 1.1 1.2
Alcohol usually taken with meals 0.8 1.2 2.6 -0.9 -0.8 -1.4 -1.3 -1.4 -1.6 1.1 1.2 -0.7 1.2 -0.7 1.4 1.1 0.7 -0.1 1.1
Nervous feelings 0.3 0.5 1.9 1.0 -0.8 0.8 1.1 1.0 0.7 -0.4 -0.3 1.4 -0.4 0.1 0.1 -0.1 -1.0 -0.2 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 3.0 -1.7 0.8 -0.8 0.3 -0.2 -0.8 0.8 0.8 -1.5 0.7 -0.8 1.5 0.9 0.2 -1.4 0.9
Hearing difficulty/problems with background noise 0.4 0.6 4.4 -0.2 -1.4 0.5 0.4 0.4 -0.9 -0.7 -0.7 0.2 -0.8 -0.3 -0.2 -0.0 -0.5 -2.1 -0.6
Hair/balding pattern: Pattern 2 1.4 1.7 4.7 -1.2 -0.1 -1.4 -1.5 -1.3 0.7 1.2 1.1 -1.1 1.3 0.9 1.9 1.3 1.1 2.2 1.6
Had menopause 0.7 0.9 2.1 1.4 -0.5 0.9 0.6 1.1 0.2 -0.9 -1.1 1.3 -1.0 0.9 -1.5 -0.2 -0.2 -0.9 -0.7
Had other major operations 0.5 0.6 2.5 -1.0 -0.1 -0.9 -1.6 -1.0 0.4 0.4 0.4 -0.8 0.5 0.2 -0.1 0.9 1.4 0.1 0.4
Forced vital capacity (FVC) 0.7 2.6 6.0 -1.3 0.9 -2.1 -1.8 -1.8 -1.3 1.5 1.6 -0.8 1.8 1.3 1.7 1.3 1.7 2.5 1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 2.9 -1.6 -1.6 -1.5 -1.7 -1.6 -0.7 0.9 0.7 -1.4 0.9 -0.1 1.3 0.9 1.1 0.5 0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.8 -0.4 1.1 -0.1 0.0 -0.2 0.3 0.4 0.3 -0.0 0.3 1.3 0.9 0.8 0.1 1.3 0.6
Qualifications: None of the above 1.6 3.3 6.9 2.3 0.1 2.3 2.3 2.6 0.7 -2.1 -1.9 0.9 -2.1 -0.4 -2.1 -1.5 -1.8 -1.5 -2.1
Financial difficulties in last 2 years 0.5 0.7 4.0 -0.6 -0.7 0.2 1.1 1.1 0.0 -0.9 -0.9 0.7 -0.7 2.0 1.1 0.5 -0.3 0.1 -0.7
Mouth/teeth dental problems 1.3 2.0 4.8 1.6 0.6 1.6 1.6 1.7 2.2 -1.6 -1.6 0.3 -1.5 -0.0 -1.3 -1.6 -1.5 -0.0 -1.8
Heart attack 0.1 0.1 1.0 0.1 -1.0 -0.2 0.1 -0.2 0.1 0.2 0.3 0.5 0.3 0.0 -0.3 0.3 0.4 -0.0 0.2
Allergy 0.2 0.4 1.9 -0.5 0.0 -0.1 -0.5 0.4 0.2 -0.4 -0.5 -1.4 -0.3 0.5 -1.4 -0.3 0.9 0.4 -0.4
Pain all over the body in last month 0.9 1.0 4.8 -0.1 2.2 -0.3 -0.1 -0.2 1.3 0.8 0.7 0.2 0.7 1.4 0.1 0.7 0.7 1.9 0.9
Diabetes (self-reported) 0.6 1.0 2.2 0.9 -1.5 1.1 1.5 0.5 0.2 -0.8 -0.5 1.0 -0.8 -0.5 -1.0 -1.3 -1.0 -1.3 -1.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.6 0.6 -0.6 0.6 1.0 0.2 -1.0 0.1 0.2 0.9 -0.0 -0.4 0.7 -0.6 -1.2 -0.3 -0.1
Medication: Ramipril 0.4 0.5 2.5 -0.5 -1.6 -0.3 0.0 -0.3 -1.2 0.7 0.8 -1.2 0.7 -0.1 -0.3 0.0 0.5 -0.0 0.5
Medication: Simvastatin 4.2 6.2 11.2 2.9 -0.2 3.4 3.0 3.2 0.2 -2.6 -2.4 3.2 -2.7 1.1 -2.6 -2.7 -2.6 -1.3 -2.6
Fluid intelligence score 0.2 0.3 1.0 -0.4 -0.1 0.4 1.0 0.1 0.6 -0.2 -0.4 -1.0 -0.4 -0.7 -0.7 -0.9 -0.0 -0.7 -0.3
Illnesses of siblings 0.2 0.3 1.5 -0.0 0.2 -0.3 0.5 0.1 1.2 -0.3 -0.5 0.8 -0.3 0.9 0.4 1.0 0.5 0.1 0.0
Neuroticism score 0.1 0.2 0.5 0.2 0.1 0.2 0.0 0.5 -0.1 0.4 0.6 -0.3 0.3 -0.7 0.4 -0.4 -0.5 -0.6 0.4
Weight 0.2 1.1 6.9 0.2 -2.6 0.6 0.5 -0.2 -2.3 -0.9 -0.5 -0.8 -0.7 0.0 -0.0 -0.7 -1.0 -0.9 -0.9
Impedance of arm (right) 0.6 2.9 9.8 -1.0 3.1 -1.8 -1.2 -1.3 -0.2 1.9 1.5 -0.2 1.7 1.0 -0.3 2.0 2.8 1.8 2.0
Arm fat percentage (right) 0.2 0.6 3.5 0.3 -1.9 0.4 0.3 0.0 -0.7 -0.6 -0.2 -0.6 -0.3 -0.6 -1.7 -0.3 0.3 -0.9 -0.7
Trunk fat-free mass 0.3 1.6 4.9 0.2 -2.2 1.0 0.7 0.2 -2.2 -1.3 -1.2 -0.6 -1.2 0.3 1.2 -1.1 -2.1 -1.0 -1.3
Hip circumference 0.4 1.7 3.2 1.0 -1.8 1.5 1.7 0.7 -1.1 -1.5 -1.1 -0.4 -1.3 -0.7 -0.8 -1.4 -1.7 -1.4 -1.6
Time employed in main current job 0.3 0.3 1.6 0.4 -1.0 0.1 0.6 0.2 0.6 0.7 0.6 1.3 0.4 -0.5 0.0 -0.2 -0.1 0.1 0.7
Alcohol intake versus 10 years previously 0.3 0.5 3.6 -0.1 0.7 -0.4 -0.7 -0.0 -1.9 0.4 0.5 0.8 0.5 0.2 1.1 0.2 -0.3 0.3 0.5
Father’s age at death 1.3 1.7 5.0 1.3 0.4 0.9 1.4 0.8 2.2 -1.2 -1.1 2.2 -0.9 1.9 -0.8 -0.7 -0.3 1.5 -1.0
Worrier / anxious feelings 0.5 1.0 2.2 1.3 -1.3 1.1 0.6 1.4 1.5 -0.6 -0.4 1.4 -0.7 -0.8 -0.5 -0.8 -1.0 -1.0 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 3.6 -1.4 0.3 -0.8 -0.4 -0.2 -0.9 0.5 0.4 -1.9 0.4 -1.1 0.7 0.3 0.4 -1.3 0.4
Falls in the last year 0.1 0.2 0.5 0.3 0.4 0.5 0.5 0.3 0.5 -0.3 -0.5 0.1 -0.5 -0.1 -0.7 -0.6 -0.3 -0.2 -0.4
Hair/balding pattern: Pattern 3 0.3 0.4 1.3 -0.5 0.1 -0.9 -0.3 -0.7 -1.2 0.7 0.9 0.3 0.9 -0.1 0.3 0.9 0.6 -0.5 0.5
Number of live births 1.5 2.1 3.9 2.0 0.2 1.7 -0.3 1.3 1.4 -1.3 -1.5 1.7 -1.6 -1.6 -1.4 -1.5 -1.7 -1.4 -1.4
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 3.3 -1.2 0.8 -1.7 -1.8 -1.4 -0.8 1.0 1.0 -0.4 1.3 1.4 0.8 1.1 1.8 1.7 1.1
Pulse rate 0.7 1.1 2.2 0.9 0.0 1.5 0.5 1.2 0.7 -1.3 -1.3 1.3 -1.4 1.2 -1.1 -0.9 -0.9 -0.3 -1.2
Happiness 0.2 0.3 1.4 -0.8 1.0 -0.1 -0.3 0.2 0.2 -0.1 -0.3 -0.6 -0.2 -0.1 1.2 0.4 -0.4 -0.2 0.1
Noisy workplace 0.6 0.8 3.0 -0.8 0.6 0.2 -0.3 0.4 -1.7 -0.1 -0.3 -1.1 -0.2 1.7 -1.4 -0.2 1.0 0.5 0.0
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.7 1.0 -0.0 0.6 1.0 0.5 0.4 -1.2 -1.2 1.3 -1.0 1.2 -0.2 -0.3 -0.5 0.2 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 2.2 -0.8 0.1 0.2 0.2 -0.0 -1.5 0.2 0.4 -0.8 0.3 0.4 -0.1 -0.5 -0.1 0.1 0.1
Mouth/teeth dental problems: Dentures 0.3 0.5 1.9 -0.1 -0.4 -0.6 -1.4 -1.2 -0.7 0.8 0.6 0.4 0.6 -0.6 0.3 0.4 0.4 -0.2 0.9
Asthma 1.0 2.0 4.0 -0.8 0.5 -1.5 -1.6 -1.7 -0.1 1.5 1.3 0.4 1.4 1.3 1.5 2.0 1.5 1.7 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 3.4 1.3 -1.1 0.5 0.1 0.8 -1.8 -0.7 -0.6 0.8 -0.6 -0.7 -0.7 -0.7 -0.7 -1.1 -0.7
Medication: Cholesterol lowering 2.5 3.9 6.4 2.4 -2.1 2.5 2.3 2.3 1.1 -1.8 -1.8 2.0 -2.0 -0.3 -2.4 -1.9 -1.9 -1.5 -1.8
Depression (self-reported) 0.8 0.9 2.3 0.7 0.1 1.5 0.5 1.4 -0.9 -1.0 -0.7 0.0 -0.9 0.9 -0.9 -1.4 -1.2 -0.3 -1.2
Medication: Lansoprazole 0.5 0.6 1.9 0.2 -0.5 -0.7 -1.0 -0.6 -0.3 0.6 0.5 0.8 0.6 1.2 0.0 0.8 1.2 1.4 0.8
Prospective memory result 0.5 0.6 3.6 0.7 0.8 0.4 0.0 0.9 1.9 -0.1 -0.3 1.4 -0.3 0.6 -1.0 0.4 0.2 0.4 -0.0
Lung cancer (father) 0.2 0.3 0.7 0.3 0.6 0.2 0.8 0.3 -0.7 -0.2 -0.2 -0.6 -0.3 -0.8 0.1 -0.5 -0.6 -0.8 -0.2
Illnesses of mother 0.3 0.4 4.0 -0.0 0.1 -0.1 0.5 0.2 -2.0 0.4 0.3 -0.4 0.4 0.7 -0.2 -0.1 0.3 0.7 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 3.1 -1.5 0.7 -1.7 -1.4 -1.6 -0.7 1.1 1.1 -0.7 1.3 1.3 1.7 1.4 1.3 1.7 1.3
Pulse wave Arterial Stiffness index 0.8 1.0 2.1 -0.2 -1.4 -0.6 -0.6 -0.8 -0.7 1.1 1.1 1.3 1.1 1.1 -0.0 0.8 1.2 1.2 1.4
Impedance of arm (left) 0.7 3.0 7.6 -1.0 2.6 -2.0 -1.4 -1.5 -0.8 2.1 1.8 -0.3 2.0 0.9 0.2 1.9 2.8 2.0 2.0
Arm fat mass (right) 0.2 0.8 6.3 0.4 -2.5 0.6 0.3 -0.1 -1.1 -0.7 -0.4 -0.8 -0.5 -0.2 -0.9 -0.5 -0.4 -0.8 -0.8
Trunk predicted mass 0.3 1.8 5.1 0.3 -2.3 1.1 0.9 0.3 -2.0 -1.4 -1.3 -0.5 -1.3 0.3 1.1 -1.2 -2.3 -1.1 -1.4
Standing height 0.2 1.7 15.0 -0.5 1.1 -0.5 0.2 -1.1 -3.9 0.1 -0.0 -0.5 0.1 1.5 2.4 0.1 -0.8 0.6 0.2
Length of working week for main job 2.7 2.9 6.2 -1.7 -1.1 -1.9 -2.5 -2.0 -0.3 1.7 1.7 -1.3 1.8 0.9 1.8 2.2 1.7 1.6 2.0
Exposure to tobacco smoke at home 0.9 1.0 5.0 -1.2 -0.0 -0.2 -1.2 -0.1 -1.1 0.7 0.3 -0.6 0.4 2.2 -0.7 0.6 1.5 1.1 0.9
Breastfed as a baby 1.5 1.9 3.5 1.3 0.6 1.8 1.3 1.4 0.7 -1.8 -1.9 1.6 -1.8 1.3 -1.0 -0.9 -1.5 -0.2 -1.5
Tense / ‘highly strung’ 1.4 2.3 8.3 1.2 -1.9 1.1 1.1 1.3 0.4 -1.4 -1.4 1.2 -1.5 -2.0 -1.0 -1.5 -1.5 -2.9 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.9 -0.9 -1.7 -0.2 0.6 0.2 -0.4 0.7 0.7 -1.4 0.7 1.0 0.7 0.4 0.1 1.5 0.8
Hair/balding pattern: Pattern 4 1.0 2.3 6.0 0.7 0.5 1.7 2.1 1.4 0.2 -1.9 -2.4 0.5 -2.2 0.2 -1.5 -1.7 -1.4 -1.1 -1.9
Birth weight of first child 0.3 0.5 2.5 0.2 1.4 0.7 0.2 0.8 -0.1 -0.6 -0.5 0.4 -0.5 1.6 -0.1 -0.3 -0.6 0.4 -0.5
Peak expiratory flow (PEF) 0.1 0.3 2.2 -0.6 -0.4 0.0 -0.2 0.5 0.4 -0.4 -0.2 -0.3 -0.1 1.5 -0.5 -0.1 0.5 0.6 -0.4
Pulse wave reflection index 1.0 1.3 2.9 -0.5 -1.2 -1.1 -1.4 -1.5 -0.4 1.3 1.3 -0.3 1.4 0.1 1.1 0.9 0.9 1.7 1.4
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.4 0.1 0.6 0.9 1.2 0.6 -0.5 0.3 0.2 -0.4 -0.0 0.2 0.4 -0.6 -1.0 0.5 0.2
Loud music exposure frequency 0.7 0.7 2.1 -1.4 1.4 -0.6 -0.1 -0.1 1.2 0.5 0.4 -0.8 0.4 1.1 0.7 1.2 0.9 0.5 0.6
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 3.2 -1.8 -0.1 -1.8 -1.2 -1.7 1.2 1.4 1.4 -0.7 1.5 1.0 1.7 1.7 1.6 1.5 1.6
Mouth/teeth dental problems: Bleeding gums 2.5 3.3 6.0 -2.4 0.5 -2.2 -2.2 -2.1 -1.1 1.9 1.9 -1.3 2.0 0.5 1.9 2.2 2.0 1.2 2.0
Blood clot in the leg (DVT) 0.7 1.0 2.7 0.5 0.3 1.0 1.0 0.6 -1.6 -1.2 -1.1 -0.1 -1.1 -0.3 0.4 -0.9 -1.6 -0.7 -1.3
Medication: Paracetamol 0.5 0.9 4.9 -0.5 -0.4 -0.5 -0.0 -0.3 -2.2 1.2 1.5 -0.7 1.2 -0.8 1.1 -0.2 -0.1 0.1 0.8
Headache pain in last month 0.2 0.3 1.1 -0.9 -0.3 0.0 -0.1 -0.3 -1.1 0.7 0.7 -1.0 0.5 -0.8 0.3 -0.1 -0.1 -0.1 0.6
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 3.0 -1.3 0.8 -1.1 -0.8 -1.2 -1.7 0.7 0.6 -0.9 0.7 -0.4 1.7 0.4 0.3 0.4 0.6
Glaucoma (self-reported) 0.1 0.1 0.6 0.7 0.8 0.1 -0.1 0.4 -0.4 -0.3 -0.2 0.5 -0.2 0.0 0.0 -0.0 -0.3 -0.5 -0.1
Gout (self-reported) 0.4 0.6 2.6 -0.3 -0.1 -0.8 -1.6 -0.8 -1.0 0.8 0.7 0.6 0.7 -0.7 0.8 0.4 0.4 0.3 1.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.9 0.0 -0.9 -0.1 -1.0 -0.5 0.5 0.4 0.4 -0.1 0.3 0.3 -0.6 0.4 0.6 0.0 0.2
Medication: Amlodipine 2.1 3.0 6.0 -1.8 0.9 -2.4 -1.8 -1.9 0.1 1.9 2.0 -2.3 2.1 -1.0 1.6 2.0 1.7 0.6 1.8
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.1 0.2 -1.3 0.5 0.1 0.4 -1.4 -0.3 -0.3 -0.1 -0.4 -1.2 -0.3 -0.9 -0.8 -0.8 -0.4
Birth weight 1.0 2.2 4.7 1.9 -0.8 1.9 1.9 1.7 -0.7 -1.6 -1.6 1.2 -1.7 1.0 -0.5 -1.6 -2.2 -0.4 -1.4
Chronic bronchitis/emphysema (mother) 0.9 1.0 3.6 1.3 -1.0 0.6 0.1 -0.2 -0.8 -1.2 -0.9 1.0 -0.9 -0.9 0.3 -0.4 -1.5 -1.9 -1.4
High blood pressure (siblings) 0.1 0.2 0.6 0.3 -0.4 0.4 0.7 0.3 -0.4 -0.1 0.0 0.3 -0.1 -0.6 -0.5 -0.7 -0.4 -0.3 -0.2
Forced vital capacity (FVC), Best measure 0.6 2.3 4.7 -1.5 0.6 -1.9 -1.3 -1.7 -1.0 1.4 1.4 -0.7 1.6 1.5 1.9 1.4 1.5 2.2 1.5
Body fat percentage 0.2 0.8 4.8 0.8 -1.4 0.8 0.8 0.4 -1.0 -0.7 -0.3 -0.4 -0.5 0.1 -2.2 -0.8 0.1 -0.6 -0.9
Leg fat percentage (right) 0.5 1.8 7.4 1.4 -1.5 1.6 1.1 1.1 -0.6 -1.3 -1.0 0.2 -1.2 -0.4 -2.7 -1.5 -0.7 -1.5 -1.4
Arm fat-free mass (right) 0.4 2.0 6.5 0.6 -2.5 1.4 1.1 0.6 -1.6 -1.6 -1.2 -0.7 -1.4 -0.2 0.4 -1.6 -2.3 -1.4 -1.6
Exposure to tobacco smoke outside home 0.6 0.8 5.9 -0.8 -0.7 0.1 -1.0 0.2 -0.4 0.1 -0.1 -0.5 0.1 2.4 0.5 0.6 0.3 1.7 0.4
Comparative body size at age 10 0.3 0.9 3.2 0.2 -1.8 1.0 -0.3 0.5 1.5 -1.2 -1.4 -0.1 -1.2 -0.2 0.3 -0.4 -1.4 -0.4 -0.9
Number of full brothers 1.2 1.4 3.1 -1.6 -0.7 -1.2 -1.6 -1.2 -0.7 1.3 1.3 -1.4 1.3 -0.9 1.8 1.3 0.5 0.4 1.2
Worry too long after embarrassment 0.3 0.4 2.9 -0.0 -0.6 -0.4 -0.2 -0.3 -0.6 0.4 0.5 0.4 0.4 -1.7 0.2 0.0 0.0 -1.5 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.1 0.1 -1.0 0.0 -0.5 0.4 -0.8 -0.0 -0.1 0.3 -0.0 0.6 0.9 0.0 -0.5 0.6 0.2
Wheeze or whistling in the chest in last year 0.6 1.0 2.4 -0.6 0.5 -1.2 -1.4 -1.4 -0.6 1.1 0.8 0.4 0.8 -0.9 1.0 1.6 1.0 -0.6 1.3
Number of children fathered 1.0 1.1 2.2 -0.7 1.4 -1.0 -0.9 -1.0 -0.8 1.5 1.3 -1.1 1.2 -1.3 0.0 0.3 1.2 0.4 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.9 1.0 0.8 0.5 0.1 0.2 -0.9 -0.1 -0.0 0.8 -0.2 -0.8 0.1 -0.4 -0.9 -0.9 -0.1
Age at first live birth 0.2 0.4 1.8 -0.5 -1.1 -0.9 -1.3 -0.9 0.2 0.2 0.5 0.4 0.6 -0.3 0.3 0.4 0.8 -0.1 0.1
Pulse wave peak to peak time 0.8 1.0 2.1 0.1 1.4 0.7 0.7 0.8 0.4 -1.2 -1.2 -1.3 -1.1 -0.9 0.2 -0.9 -1.3 -1.1 -1.4
Health satisfaction 1.0 1.3 2.6 -1.0 0.8 -1.6 -0.7 -1.5 -0.9 1.2 1.5 -0.5 1.4 -0.2 1.3 1.3 1.2 0.1 1.3
Shortness of breath walking on level ground 0.5 0.7 1.4 -0.6 0.7 -0.8 -0.8 -0.7 0.6 1.1 1.2 -0.4 1.1 0.2 0.7 0.9 0.7 0.8 1.1
Qualifications: College or University degree 0.1 0.3 2.4 -0.3 1.6 -0.3 -0.2 -0.2 0.2 -0.7 -0.8 0.1 -0.5 0.7 -0.0 0.5 0.4 -0.3 -0.5
Eye problems/disorders: None of the above 1.2 1.4 9.7 -1.2 -0.5 -1.2 -0.8 -1.1 0.5 0.7 0.5 -1.1 0.6 -3.1 1.9 0.4 -0.4 -1.3 0.4
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.6 0.1 -0.7 0.1 0.4 0.3 0.5 -0.6 -0.5 0.0 -0.5 -0.1 0.6 0.5 -0.4 -0.8 -0.4
Emphysema/chronic bronchitis 0.3 0.4 0.9 0.2 0.4 0.6 0.4 0.5 -0.3 -0.8 -0.8 0.7 -0.8 0.3 0.7 -0.1 -1.0 -0.5 -0.7
Medication for pain relief, constipation, heartburn 0.5 0.9 2.9 -1.1 0.3 -0.9 -0.9 -1.3 1.7 0.6 0.3 -0.9 0.5 0.6 0.4 1.0 1.3 0.9 0.7
Neck or shoulder pain in last month 0.9 1.2 3.1 -1.3 -1.4 -0.5 -0.3 -0.8 -1.7 1.5 1.7 -1.7 1.3 0.3 0.5 0.4 0.4 0.6 1.0
Medication: Blood pressure 0.2 0.4 1.9 -0.5 0.2 -0.1 -0.5 -0.0 1.4 -0.0 0.0 -0.8 0.1 1.3 0.1 1.2 0.5 0.5 0.3
Angina (self-reported) 1.0 1.3 3.5 -1.0 -1.5 -1.1 -1.1 -0.9 -0.3 1.2 1.4 -0.7 1.3 0.3 1.0 1.9 1.2 0.6 1.3
Migraine (self-reported) 0.5 0.6 5.3 0.3 0.1 -0.1 -0.7 -0.5 0.2 -0.2 -0.0 1.2 0.1 2.3 0.5 0.5 0.3 1.3 0.0
Medication: Ibuprofen 0.3 0.4 1.9 1.2 -0.3 0.3 -0.2 0.5 -1.4 -0.5 -0.3 0.8 -0.3 0.1 -0.5 -0.4 -0.4 -0.2 -0.4
Medication: Allopurinol 1.6 2.2 4.6 -1.3 1.0 -1.6 -2.1 -1.6 -1.6 1.8 1.6 -0.6 1.6 0.3 1.2 1.2 1.4 1.6 1.9
Medication: Omeprazole 0.4 0.5 2.0 -0.6 -1.4 -0.1 -0.3 -0.1 1.3 -0.2 -0.4 -0.4 -0.3 -0.3 1.3 0.6 -0.7 -0.8 -0.2
Medication: Seretide 50 evohaler 0.2 0.2 1.1 -0.6 0.8 -0.3 -0.1 -1.1 0.4 0.2 0.3 -0.2 0.2 -0.3 -0.0 0.3 0.6 -0.7 0.2
Mean time to correctly identify matches 1.9 3.6 7.4 1.8 0.5 2.3 2.7 2.6 -0.8 -2.0 -1.7 1.2 -2.0 0.4 -2.3 -2.0 -1.5 -2.1 -2.2
Heart disease (mother) 0.6 0.8 3.7 -0.4 -0.6 -0.3 -0.5 -0.4 -1.6 0.1 0.1 -1.4 0.1 -1.9 -0.8 -0.5 0.2 -1.6 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 2.7 -0.7 -1.6 -0.0 -0.1 -0.4 0.9 0.3 0.2 -0.9 0.3 0.8 0.4 0.0 0.3 1.3 0.3
Whole body fat mass 0.2 0.9 4.0 0.8 -2.0 0.9 0.9 0.3 -1.3 -0.9 -0.6 -0.4 -0.8 0.2 -1.4 -0.9 -0.5 -0.9 -1.1
Leg fat mass (right) 0.5 1.9 3.8 1.4 -2.0 1.6 1.1 1.0 -0.8 -1.6 -1.2 0.0 -1.4 -0.3 -1.9 -1.7 -1.3 -1.6 -1.7
Arm predicted mass (right) 0.3 1.5 5.9 0.4 -2.4 1.0 0.9 0.3 -1.5 -1.3 -1.0 -0.7 -1.1 0.1 0.7 -1.3 -2.0 -1.1 -1.3
Pulse rate, automated reading 0.1 0.4 2.4 -0.6 -0.6 -0.4 -0.4 -0.8 -1.5 0.7 0.7 -0.4 0.6 -0.7 0.4 -0.3 0.1 -0.5 0.4
Alcohol intake frequency. 0.7 1.5 3.4 -1.3 0.1 -1.4 -1.9 -1.2 0.4 1.3 1.3 -0.8 1.3 0.4 1.4 1.5 1.2 1.5 1.3
Comparative height size at age 10 0.2 1.3 7.9 0.1 0.8 0.5 -0.3 -0.2 -2.8 -0.5 -0.6 -0.3 -0.5 2.8 1.3 0.2 -0.9 1.1 -0.1
Number of full sisters 0.3 0.3 1.0 0.2 0.8 0.6 0.4 0.2 -0.8 -0.4 -0.2 -1.0 -0.3 -0.5 -0.2 -0.8 -0.9 -0.2 -0.5
Suffer from ‘nerves’ 0.2 0.4 2.2 -0.0 1.5 -0.1 0.3 0.5 0.8 0.1 0.1 0.1 0.2 0.7 1.1 0.6 -0.3 0.4 0.3
Overall health rating 1.1 2.3 4.0 -1.8 -0.6 -1.8 -1.1 -1.6 -1.4 2.0 1.9 -2.0 1.8 -1.0 1.2 1.3 1.4 -0.2 1.9
Chest pain or discomfort 0.7 1.1 3.1 -0.8 1.2 -0.9 -0.6 -0.9 -0.5 1.3 1.3 -0.6 1.2 -0.0 1.8 1.4 0.4 0.5 1.5
Had major operations 0.6 0.7 3.9 0.4 -2.0 0.0 -0.1 -0.1 -1.6 -0.1 -0.1 -0.7 -0.1 -1.4 0.4 -0.2 -0.7 -1.4 -0.1
Age at last live birth 0.4 0.6 3.3 0.2 0.3 -0.1 -0.3 -0.3 1.5 -0.4 -0.0 1.0 -0.1 -1.8 -0.5 -0.6 0.0 -1.4 -0.6
Family relationship satisfaction 0.4 0.5 3.2 -0.6 -0.9 -0.3 -0.7 -0.4 -1.8 0.3 0.3 -0.7 0.4 0.9 1.0 0.4 0.0 0.9 0.4
Leg pain on walking 0.4 0.6 1.6 -1.0 1.1 -0.8 -1.0 -0.4 0.5 0.5 0.2 -0.5 0.4 0.8 -0.1 1.1 1.3 -0.1 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.1 3.9 -1.4 1.0 -0.7 -0.5 -0.5 0.4 1.2 1.0 -1.3 0.9 1.0 2.0 1.0 0.1 1.4 1.3
Commuting to job workplace: Car/motor vehicle 3.2 3.6 5.7 -2.4 -0.0 -2.1 -2.2 -2.1 0.2 2.3 2.4 -2.2 2.3 0.6 1.1 2.1 2.3 1.8 1.9
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.8 -0.1 0.8 -0.2 -0.6 -0.9 0.3 0.5 0.6 -0.2 0.5 -0.1 -0.2 0.1 0.4 0.6 0.5
Medication: Aspirin 0.2 0.3 1.4 0.2 0.5 -0.4 0.1 0.0 -1.2 0.5 0.9 0.6 0.7 -0.1 0.2 0.2 0.3 0.2 0.5
Supplements: Vitamin C 0.3 0.4 1.2 0.6 -1.1 0.4 0.7 0.7 -1.0 -0.5 -0.6 0.6 -0.5 0.4 -0.1 -0.5 -0.5 -0.3 -0.6
Knee pain experienced in last month 1.5 2.3 4.9 2.2 -0.3 2.0 1.2 2.0 0.1 -1.4 -1.3 1.9 -1.6 -0.2 -0.8 -1.5 -2.2 -1.7 -1.4
Hypertension (Self-reported) 0.6 1.6 2.8 0.6 -0.2 1.6 1.7 1.4 1.1 -1.7 -1.4 0.3 -1.6 -0.2 -1.5 -1.0 -1.1 -1.6 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.6 5.7 1.7 -2.4 1.0 0.6 0.8 -0.0 -1.0 -1.4 1.6 -1.3 -0.7 -1.0 -0.7 -1.0 -2.1 -1.0
Illnesses of father: Heart disease 0.6 0.9 2.0 1.4 1.2 0.9 0.2 0.9 0.2 -1.0 -1.1 1.4 -1.1 -0.4 -0.5 -1.0 -0.9 -0.7 -1.0
Illnesses of siblings: Diabetes 0.8 1.0 3.7 -1.0 0.1 -0.3 -1.3 -0.7 -1.9 0.6 1.0 -1.3 0.9 1.1 -0.8 -0.5 1.0 1.2 0.2
Smoking status: Previous 1.2 1.7 3.9 1.1 -0.1 1.8 1.2 1.0 0.7 -1.5 -1.5 0.3 -1.6 -1.3 -0.9 -1.7 -2.0 -1.3 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 4.8 -1.8 0.1 -1.1 -0.5 -0.8 -0.7 0.7 0.6 -2.2 0.8 1.6 1.8 1.4 0.6 1.9 0.8
Whole body fat-free mass 0.3 1.4 7.5 0.1 -2.7 0.8 0.5 -0.0 -2.0 -1.1 -0.9 -0.8 -0.9 0.2 1.1 -0.9 -1.8 -0.9 -1.1
Leg fat-free mass (right) 0.2 1.2 10.4 -0.2 -3.2 0.1 0.1 -0.5 -1.8 -0.7 -0.4 -0.8 -0.4 0.0 1.2 -0.4 -1.1 -0.5 -0.7
Arm fat percentage (left) 0.2 0.7 4.8 0.6 -2.2 0.4 0.3 0.1 -0.7 -0.5 -0.2 -0.5 -0.3 -0.7 -1.8 -0.5 0.3 -0.8 -0.7
Average weekly red wine intake 0.3 0.5 2.4 -0.8 0.4 -0.8 0.1 -0.4 -0.7 0.5 0.8 -1.1 0.8 -0.8 1.5 0.3 -0.1 0.0 0.3
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.3 0.2 0.6 0.1 -0.2 0.3 -1.1 -0.6 -0.5 1.2 -0.4 0.4 0.9 0.2 -0.7 -0.2 -0.5
Mood swings 1.2 2.1 5.0 -1.5 -0.5 -1.7 -1.1 -1.4 1.2 2.0 1.7 -1.4 1.7 -1.0 2.2 1.5 0.7 0.6 1.8
Loneliness, isolation 0.2 0.2 1.2 0.2 0.2 -0.1 0.5 0.3 -1.1 0.3 0.3 0.1 0.2 -0.7 0.8 -0.3 -0.6 -0.6 0.2
Long-standing illness, disability or infirmity 0.1 0.2 2.5 0.2 -1.6 -0.0 -0.3 -0.1 -0.0 0.3 0.3 -0.3 0.2 0.0 -0.1 0.3 0.0 0.3 0.3
Ever had bowel cancer screening 0.5 0.6 2.7 -0.9 -0.7 0.0 0.3 -0.3 -1.2 0.3 0.5 -1.3 0.3 0.8 -1.7 -0.0 1.1 0.2 0.1
Diabetes diagnosed by doctor 1.2 2.0 6.2 0.8 -0.9 1.9 2.5 1.3 -0.4 -1.4 -1.0 0.6 -1.3 0.0 -1.5 -2.1 -1.6 -1.5 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 4.4 0.9 -0.2 1.5 1.3 1.1 -1.0 -1.0 -1.0 1.0 -1.1 -1.2 -0.2 -1.8 -2.1 -0.9 -1.2
Friendships satisfaction 0.4 0.5 1.6 0.1 0.2 0.9 0.6 1.3 -0.5 -0.8 -0.7 0.3 -0.8 0.9 0.6 -0.5 -1.1 -0.1 -0.4
Qualifications: nursing, teaching 0.1 0.2 1.1 0.0 -1.1 0.0 -0.1 -0.2 0.4 -0.6 -0.5 0.5 -0.3 0.1 0.2 -0.5 -0.3 0.2 -0.6
Commuting to job workplace: Walk 1.3 1.4 3.8 1.7 -0.8 1.3 0.5 1.3 0.6 -1.4 -1.5 1.9 -1.4 0.8 -1.2 -0.8 -0.9 -0.1 -1.2
Eye problems/disorders: Cataract 3.3 3.8 6.3 2.5 1.7 2.3 2.2 2.1 -0.9 -2.4 -2.1 1.9 -2.1 1.5 -2.5 -1.8 -1.3 -0.5 -2.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.9 0.1 -0.3 0.5 0.9 0.6 -0.7 -0.0 -0.1 -0.3 -0.2 0.2 -0.5 -0.5 -0.3 0.1 -0.0
Medication for cholesterol 0.2 0.4 1.3 0.5 1.1 0.7 0.7 0.2 -0.0 -0.6 -1.0 0.0 -0.8 0.6 -0.6 -0.5 -0.5 -0.1 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 3.0 0.5 1.7 0.7 0.7 0.5 -0.2 0.1 -0.0 0.4 -0.2 1.0 -0.4 -0.1 -0.4 0.3 -0.0
Back pain experienced in last month 0.1 0.2 0.7 0.2 -0.8 -0.0 -0.2 0.2 -0.3 0.4 0.6 0.2 0.4 -0.1 -0.7 0.1 0.5 -0.3 0.5
Mineral and other dietary supplements 1.6 2.2 4.4 -1.4 1.3 -2.1 -1.2 -1.7 0.4 1.6 1.6 -1.4 1.7 -1.6 1.0 1.8 1.8 -0.4 1.5
Breast cancer (self-reported) 0.4 0.5 1.6 -0.0 0.2 -0.4 -0.7 -1.2 -1.1 0.7 0.8 0.1 0.7 -0.6 -1.3 -0.2 1.0 0.3 0.4
Asthma (self-reported) 1.4 2.7 5.3 -1.2 0.7 -1.9 -1.9 -2.0 0.2 1.8 1.6 0.1 1.8 1.3 1.8 2.3 1.8 1.9 2.1
Osteoporosis (self-reported) 0.7 0.8 7.5 -0.5 -0.1 -0.1 -1.1 -0.0 -2.7 0.1 0.3 -1.0 0.2 -0.2 1.4 0.4 -0.8 -0.2 0.2
Osteoarthritis (self-reported) 0.4 0.6 4.6 1.1 -2.1 0.2 -0.8 -0.1 -1.0 -0.1 -0.1 0.9 -0.1 -0.2 0.1 -0.7 -0.6 0.4 0.1
Medication: Aspirin 0.2 0.2 1.8 0.1 0.2 -0.1 0.0 0.2 -1.4 0.4 0.8 0.2 0.6 0.1 0.1 0.1 0.2 0.1 0.4
Medication: Gliclazide 0.1 0.1 0.4 -0.6 0.1 -0.1 -0.4 0.1 -0.2 0.2 0.1 -0.0 0.1 0.6 -0.5 0.1 0.5 -0.2 0.1
Illnesses of father: None of the above (group 1) 0.6 0.7 2.5 -0.6 -1.2 -0.6 -0.6 -0.8 -0.4 0.8 0.8 -0.8 0.8 0.5 -1.2 0.7 1.6 0.6 0.9
Smoking status: Current 1.5 2.4 4.3 -2.1 0.4 -1.7 -1.7 -1.5 -0.8 1.9 1.8 -1.8 1.8 -0.1 1.8 1.6 1.3 1.3 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 5.4 1.2 -0.4 0.7 0.3 0.7 0.6 -1.1 -1.0 2.3 -0.9 0.4 -0.7 -0.9 -0.7 -0.5 -1.1
Whole body water mass 0.3 1.5 7.7 0.1 -2.8 0.8 0.6 -0.0 -2.0 -1.2 -0.9 -0.8 -1.0 0.2 1.2 -0.9 -1.9 -1.0 -1.1
Leg predicted mass (right) 0.2 1.2 10.6 -0.2 -3.2 0.1 0.1 -0.5 -1.9 -0.7 -0.4 -0.8 -0.4 0.0 1.2 -0.4 -1.1 -0.6 -0.7
Arm fat mass (left) 0.2 1.0 7.4 0.6 -2.7 0.8 0.6 0.2 -1.1 -0.9 -0.6 -0.7 -0.7 -0.3 -1.0 -0.7 -0.6 -1.0 -1.0
Number of self-reported non-cancer illnesses 0.6 1.0 2.9 1.6 -1.7 1.1 0.4 0.7 -0.6 -0.5 -0.3 1.2 -0.6 -0.6 -1.5 -1.4 -1.0 -0.9 -0.8
Average weekly champagne plus white wine intake 0.3 0.5 2.0 -0.1 -0.5 -0.7 -0.8 -0.7 -1.4 0.6 0.8 1.0 0.7 0.1 0.2 0.5 0.9 0.2 0.6
Miserableness 0.6 1.0 2.6 -1.1 -0.1 -0.5 -1.0 -0.7 -0.9 1.2 1.3 -1.1 1.1 1.6 0.2 0.7 1.0 1.2 1.2
Guilty feelings 0.3 0.4 2.9 -0.3 1.0 -0.1 -0.3 0.1 -1.7 0.5 0.5 -1.0 0.4 0.3 0.6 -0.2 -0.3 0.3 0.2
Wears glasses or contact lenses 0.4 0.5 1.4 0.5 0.4 0.5 0.7 0.4 0.0 -0.9 -0.8 0.4 -0.8 -1.0 -0.3 -0.4 -0.8 -1.2 -0.7
Ever taken oral contraceptive pill 0.6 0.7 4.2 0.9 -1.1 0.5 0.3 0.3 0.2 -0.1 0.4 0.9 0.1 -2.1 0.4 -1.1 -1.4 -0.4 -0.2
Hearing aid user 0.9 1.0 2.1 1.1 0.7 1.2 0.6 1.5 0.1 -1.2 -1.1 0.9 -1.1 0.7 -0.6 -1.3 -1.2 0.2 -1.1
Mother’s age at death 0.6 0.8 5.6 1.0 -0.1 0.7 0.7 0.5 0.7 -0.8 -1.0 2.4 -0.9 1.0 -0.5 -0.4 -0.3 -0.5 -0.5
Financial situation satisfaction 0.5 0.6 2.8 -0.5 -1.4 -0.2 0.1 0.2 -1.2 -0.3 -0.3 -0.1 -0.1 1.7 1.2 0.3 -0.1 1.4 0.0
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.7 0.8 0.1 0.6 1.0 0.6 -1.2 -0.4 -0.8 1.7 -0.7 0.4 0.1 -0.4 -1.0 -1.0 -0.4
Commuting to job workplace: Public transport 1.6 1.9 4.2 2.0 -1.0 1.6 1.4 1.2 -1.2 -1.2 -1.5 2.1 -1.5 0.2 -1.4 -1.4 -1.3 -0.9 -1.0
Eye problems/disorders: Glaucoma 0.5 0.6 2.2 0.6 1.4 0.6 0.4 1.2 0.9 -0.8 -0.8 0.6 -0.8 1.5 -0.3 0.2 -0.1 -0.2 -0.5
Medication: Blood pressure 0.7 1.4 3.2 -1.8 -0.7 -1.5 -0.7 -1.3 0.5 1.3 1.5 -1.0 1.4 -0.4 0.9 1.4 1.5 0.3 1.3
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.8 -0.4 0.8 -0.4 0.3 -0.6 -0.6 0.5 0.7 -0.1 0.6 0.5 -0.7 -0.3 0.9 0.6 0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.8 0.8 -0.6 1.5 0.7 1.1 -1.2 -1.0 -0.8 0.4 -0.9 0.8 -0.3 -1.7 -1.4 0.8 -1.1
High cholesterol (Self-reported) 1.0 1.8 4.0 1.6 -1.5 1.9 1.5 2.0 -0.4 -1.1 -0.9 1.4 -1.1 -0.2 -1.2 -1.7 -1.8 -0.6 -1.2
Medication: Bendroflumethiazide 1.1 1.6 4.1 -1.6 -0.7 -1.2 -0.8 -1.2 -2.0 1.4 1.7 -1.6 1.6 0.0 1.1 0.7 1.0 0.9 1.3
Medication: Paracetamol 1.3 2.0 4.6 -1.5 -0.0 -1.3 -1.0 -1.1 -1.9 1.8 2.1 -1.3 1.9 0.2 1.9 0.8 0.7 1.1 1.5
Medication: Lisinopril 0.6 0.8 5.7 0.5 -2.4 -0.3 -0.2 -0.2 2.1 -0.1 -0.1 1.1 0.0 0.2 0.5 0.9 0.1 0.4 0.2
Medication: Atorvastatin 0.7 0.9 1.8 -0.5 -0.4 -1.3 -1.2 -1.0 0.8 1.0 0.8 -0.7 1.0 -1.2 0.3 1.3 1.2 0.0 1.1
Illnesses of father: High blood pressure 0.5 0.6 3.3 -0.7 -0.6 -0.9 -0.3 -0.5 -0.5 0.6 0.6 -1.0 0.7 -0.9 1.8 0.7 -0.2 0.1 0.5
Alcohol drinker status: Never 0.2 0.2 1.4 0.1 0.3 0.0 0.0 0.3 1.1 0.0 0.2 0.2 0.2 0.8 0.5 0.3 -0.2 1.2 0.0
Ever smoked 0.6 1.0 3.9 0.1 0.4 1.0 0.2 0.7 -0.3 -1.0 -0.8 -1.1 -0.9 -2.0 -0.1 -1.3 -1.4 -1.3 -1.0
Basal metabolic rate 0.3 1.4 8.1 0.1 -2.8 0.7 0.5 -0.1 -2.1 -1.0 -0.8 -0.9 -0.8 0.2 1.0 -0.8 -1.7 -0.8 -1.0
Leg fat percentage (left) 0.5 1.9 8.6 1.5 -1.5 1.7 1.1 1.2 -0.5 -1.3 -1.0 0.3 -1.2 -0.3 -2.9 -1.7 -0.6 -1.5 -1.5
Arm fat-free mass (left) 0.4 2.1 6.7 0.6 -2.6 1.4 1.2 0.5 -1.5 -1.5 -1.2 -0.5 -1.4 -0.3 0.7 -1.4 -2.5 -1.6 -1.5
Number of operations (self-reported) 0.5 0.8 8.1 -0.0 -2.8 -0.0 -0.9 -0.5 -1.1 -0.2 0.1 -0.5 -0.0 -0.9 0.2 -0.2 -0.3 -0.7 -0.3
Average weekly beer plus cider intake 0.2 0.3 1.2 -0.1 0.5 0.6 0.9 0.7 0.1 -0.2 -0.2 -0.6 -0.3 0.0 -0.6 -1.1 -0.4 0.2 -0.4
Irritability 0.3 0.5 2.0 -1.4 -0.5 -0.7 0.5 -0.3 0.3 0.7 0.6 -1.0 0.6 0.6 1.1 0.7 0.6 0.3 0.8
Risk taking 0.8 1.1 6.9 -1.6 -2.6 -0.7 -0.4 -0.8 -0.4 0.8 0.5 -1.6 0.6 0.5 0.4 1.1 1.0 0.0 0.8
Ever had prostate specific antigen (PSA) test 1.0 1.2 3.1 0.0 -0.1 -0.9 -1.8 -1.5 0.5 1.2 1.2 -0.3 1.2 1.1 -0.0 1.4 1.3 1.5 1.3
Fractured/broken bones in last 5 years 0.3 0.4 1.6 -0.7 -0.5 -0.5 -0.4 -1.3 -0.3 0.7 0.6 -0.5 0.6 -1.0 0.8 0.1 0.2 0.2 0.7
Age started oral contraceptive pill 0.5 0.7 4.7 1.5 -1.0 0.4 -0.2 0.2 -0.9 -0.1 0.1 2.2 -0.0 0.8 0.5 -0.1 -0.8 -0.1 -0.0
Diastolic blood pressure, automated reading 0.2 0.7 2.7 -1.0 -0.7 -0.8 -0.6 -1.4 -1.6 0.6 0.6 -1.3 0.7 -0.7 0.6 0.3 0.6 -0.2 0.6
Ever depressed for a whole week 0.2 0.3 1.1 -0.4 0.1 -0.1 -0.7 -0.2 -0.3 0.4 0.5 -0.3 0.5 1.0 1.0 0.6 -0.0 0.8 0.5
Unable to work because of sickness or disability 0.5 0.7 3.0 0.3 -0.2 0.8 0.4 0.7 -0.6 -0.5 -0.3 0.1 -0.5 -1.5 1.0 -0.6 -1.7 -1.4 -0.7
Commuting to job workplace: Cycle 1.3 1.6 5.9 1.5 -1.2 0.7 1.2 1.2 1.9 -1.3 -1.6 2.4 -1.4 0.1 -0.0 -0.4 -0.9 -0.3 -1.2
Myopia 0.8 1.2 3.2 1.1 -0.9 0.9 1.8 0.7 0.7 -1.4 -1.7 0.5 -1.5 -0.1 -0.8 -0.7 -1.0 -1.0 -1.3
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.0 -0.3 0.8 -1.1 -0.9 -1.0 -1.4 1.2 1.0 -0.5 1.1 -0.3 1.1 0.5 0.6 1.0 1.1
Cholesterol lowering medication 1.3 1.9 5.1 1.3 0.9 1.7 1.3 2.3 -0.7 -1.5 -1.4 1.4 -1.5 1.3 -1.1 -1.4 -1.3 -0.6 -1.4
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 3.1 -0.1 -1.8 0.6 0.4 0.9 1.1 -0.9 -1.1 0.3 -1.0 1.0 1.3 0.4 -1.2 -0.5 -0.7
Pain experienced in last month 0.7 1.2 4.2 1.0 0.2 0.9 0.6 1.0 1.0 -1.6 -2.1 0.6 -1.7 0.1 -1.2 -0.7 -0.5 -0.9 -1.4
Supplements: Calcium 2.6 2.8 6.0 -1.4 -0.8 -1.7 -1.6 -2.0 -1.2 1.9 1.9 -0.8 1.9 1.0 2.5 2.3 1.1 1.8 1.9
Basal cell carcinoma (self-reported) 1.2 1.4 4.7 -1.4 -0.2 -1.6 -1.1 -1.0 0.1 1.2 1.3 -1.3 1.4 -0.3 2.2 1.0 0.5 1.3 1.2
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.5 -0.2 -0.6 -0.5 -0.2 -0.6 0.2 0.6 0.7 0.1 0.6 0.0 0.0 0.7 0.7 0.3 0.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.6 0.3 0.6 0.8 1.0 0.5 -1.9 -1.0 -1.0 -0.4 -1.0 -0.6 0.4 -0.9 -1.5 -0.8 -1.2
Heart disease (siblings) 3.2 3.9 9.5 -1.8 0.5 -2.0 -2.2 -2.0 -2.2 2.5 2.5 -3.1 2.4 -1.2 1.4 1.2 1.5 1.2 2.2
Alcohol drinker status: Previous 0.3 0.3 2.7 -0.1 -0.5 0.3 0.4 0.5 1.7 0.0 0.1 -0.8 0.0 0.1 0.2 -0.2 -0.4 0.7 0.0
Pack years of smoking 0.4 0.6 1.8 -0.1 -0.2 -0.5 -0.4 -0.8 0.1 1.2 1.3 -0.8 1.1 -0.7 0.6 0.3 0.2 1.1 1.0
Impedance of whole body 0.4 2.2 14.1 -0.5 3.8 -1.3 -0.5 -0.7 -0.1 1.7 1.4 -0.0 1.5 0.7 -0.7 1.1 2.2 1.5 1.6
Leg fat mass (left) 0.4 1.6 4.6 1.2 -2.1 1.5 0.9 0.8 -0.8 -1.4 -1.0 -0.1 -1.2 -0.2 -1.8 -1.6 -1.1 -1.4 -1.6
Arm predicted mass (left) 0.4 1.8 6.0 0.7 -2.5 1.3 1.1 0.5 -1.6 -1.5 -1.2 -0.4 -1.3 -0.1 0.8 -1.3 -2.4 -1.4 -1.4