TWAS hub - PCNA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1754	0.0543	0.00180	0.116	NA	0.090	NA	0.108	2.2e-09	NA	1.5e-07	NA	8.5e-09
2	GTEx	Nerve Tibial	0.2001	0.0561	0.00022	0.121	NA	0.076	NA	0.106	7.1e-09	NA	5.0e-06	NA	6.4e-08
3	TCGA	Brain Lower Grade Glioma	0.0347	0.0198	0.00490	0.000	0.009	-0.001	NA	0.001	2.7e-01	0.031	4.4e-01	NA	2.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bilateral oophorectomy (both ovaries removed)	7.1	8.2	11.3	2.7	2.5	3.4
Ever taken oral contraceptive pill	6.1	6.8	10.1	-2.0	-2.5	-3.2
Noisy workplace	5.9	7.3	14.1	2.1	1.9	3.8
Comparative height size at age 10	5.9	32.4	38.2	6.2	5.9	4.9
Relative age voice broke	5.8	8.8	15.4	-2.3	-2.4	-3.9
Average weekly spirits intake	5.7	7.0	9.2	2.2	2.6	3.0
Severe depression (siblings)	5.4	6.0	10.7	-1.9	-1.9	-3.3
Osteoporosis (self-reported)	5.1	6.3	8.5	2.9	2.9	1.5
Mineral and other dietary supplements	4.8	6.4	8.1	-2.6	-2.1	-2.9
Height	4.7	90.4	97.2	9.9	9.8	8.8
Rheumatoid Arthritis	4.3	6.0	6.7	2.6	2.6	2.1
Alzheimer’s Disease (in mother)	4.2	4.9	5.8	-2.0	-2.2	-2.4
Financial difficulties in last 2 years	4.2	5.6	6.6	2.6	2.5	2.0
Birth weight	4.2	9.1	10.2	2.7	3.2	3.2
Serious illness, injury or assault of a close relative in last 2 years	4.1	4.7	6.3	1.9	2.1	2.5
Standing height	3.8	38.2	47.7	6.9	6.7	4.7
Age at last live birth	3.7	5.4	6.2	-2.2	-2.5	-2.3
Major Depression (MDD)	3.5	4.3	6.6	2.6	2.3	1.1
Lupus	3.4	5.2	8.2	-2.2	-2.9	-1.6
Illness, injury, bereavement, stress in last 2 years	3.3	4.0	5.5	-1.7	-1.9	-2.4
Trunk fat-free mass	3.1	17.7	22.8	4.8	4.6	3.1
Eye problems/disorders: Cataract	3.1	3.6	8.1	1.1	1.3	2.9
Financial situation satisfaction	3.1	3.9	5.0	2.1	2.2	1.4
Relative age of first facial hair	3.0	6.1	11.2	-1.6	-2.1	-3.4
Trunk predicted mass	3.0	17.1	21.9	4.7	4.5	3.0
Supplements: Fish oil (including cod liver oil)	3.0	4.0	5.2	2.3	1.9	1.8
Alzheimer’s Disease (including proxy)	2.9	4.2	4.9	-2.0	-2.2	-1.9
Medication for hormone replacement therapy	2.9	3.2	3.5	-1.9	-1.9	-1.7
Vitamin and mineral supplements	2.9	4.0	9.1	-1.2	-1.2	-3.0
Exposure to tobacco smoke at home	2.9	3.2	5.1	1.7	1.3	2.3
Miserableness	2.8	4.8	5.1	2.3	2.1	2.2
Diabetes (father)	2.7	3.3	4.0	-1.6	-1.8	-2.0
Had major operations	2.7	3.2	4.0	2.0	1.8	1.6
Commuting to job workplace: Cycle	2.7	3.3	4.0	-1.8	-1.6	-2.0
Depression (self-reported)	2.6	3.2	3.9	1.7	1.7	2.0
Prospective memory result	2.5	3.1	3.6	-1.9	-1.9	-1.5
Eye problems/disorders: None of the above	2.5	2.9	6.4	-1.0	-1.2	-2.5
Medication: Atorvastatin	2.5	3.1	4.5	-2.1	-1.8	-1.3
Time employed in main current job	2.4	2.8	3.2	-1.8	-1.7	-1.5
Number of live births	2.4	3.4	4.7	-1.9	-2.2	-1.4
Arm predicted mass (right)	2.4	12.5	16.2	4.0	3.8	2.6
Illnesses of siblings: Diabetes	2.4	2.9	3.8	1.6	1.5	2.0
Whole body fat-free mass	2.4	13.8	17.9	4.2	4.0	2.7
Friendships satisfaction	2.4	3.0	3.7	1.8	1.9	1.5
Whole body water mass	2.4	13.7	18.0	4.2	4.0	2.7
Hearing difficulty/problems: Yes	2.3	3.4	4.9	1.9	1.4	2.2
Multivitamins +/- minerals	2.3	2.9	7.5	0.9	0.7	2.7
Arm fat-free mass (right)	2.3	12.0	15.3	3.9	3.7	2.6
Bipolar Disorder (2018)	2.2	3.5	4.0	-2.0	-1.8	-1.8
Supplements: Glucosamine	2.2	2.8	4.4	2.1	1.4	1.5
Mean time to correctly identify matches	2.2	4.2	7.0	1.5	1.8	2.7
Basal metabolic rate	2.2	12.4	15.9	4.0	3.8	2.6
Cholesterol lowering medication	2.2	3.2	5.6	1.0	1.7	2.4
Arm predicted mass (left)	2.2	11.2	14.6	3.8	3.6	2.4
Depression (Nagel 2018)	2.1	3.1	3.9	1.6	1.8	2.0
Heart disease (mother)	2.1	2.6	2.7	1.6	1.6	1.6
Medication: Lisinopril	2.1	2.8	3.6	-1.5	-1.6	-1.9
Blood Platelet Count	2.0	22.7	27.1	-4.8	-4.3	-5.2
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	4.0	1.7	2.0	1.6
Medication for cholesterol	2.0	3.0	3.6	1.9	1.5	1.7
Guilty feelings	2.0	3.0	3.9	2.0	1.8	1.4
Arm fat-free mass (left)	2.0	10.3	13.6	3.7	3.5	2.2
Sitting height	1.9	13.2	18.9	4.3	3.9	2.3
Family relationship satisfaction	1.9	2.4	2.9	1.7	1.6	1.3
Ever had bowel cancer screening	1.9	2.2	4.7	1.1	0.8	2.2
Age started oral contraceptive pill	1.8	2.2	2.7	1.5	1.7	1.3
Leg fat-free mass (left)	1.7	8.9	11.8	3.4	3.2	2.1
Leg predicted mass (left)	1.7	9.2	12.1	3.5	3.3	2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.4	5.0	2.0	2.2	1.2
Number of incorrect matches in round	1.6	2.6	3.7	1.5	1.4	1.9
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	3.9	1.6	2.0	0.9
Irritability	1.6	2.8	3.3	1.6	1.8	1.6
Weight	1.5	7.4	8.5	2.9	2.7	2.5
Peak expiratory flow (PEF)	1.5	3.5	5.9	1.5	1.5	2.4
Pulse wave reflection index	1.5	1.8	2.2	-1.2	-1.3	-1.5
Exposure to tobacco smoke outside home	1.5	2.0	2.9	1.2	1.3	1.7
Neck or shoulder pain in last month	1.5	2.1	2.9	1.3	1.4	1.7
Leg fat-free mass (right)	1.5	7.9	10.9	3.3	3.1	1.9
Leg predicted mass (right)	1.5	8.2	11.2	3.3	3.1	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	2.6	1.6	1.6	0.6
Neuroticism (2016)	1.3	1.8	2.9	-1.0	-1.3	-1.7
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.5	-1.1	-1.6	-0.9
Chronotype (morning person)	1.3	3.1	4.2	-1.7	-1.5	-2.0
Heart disease (siblings)	1.3	1.6	2.4	1.4	1.5	0.7
HbA1C	1.2	1.3	2.1	1.4	1.2	0.5
Hearing difficulty/problems with background noise	1.2	2.0	2.5	1.6	1.0	1.5
Medication: Simvastatin	1.2	1.7	4.4	0.5	0.6	2.1
Forced vital capacity (FVC), Best measure	1.2	4.5	5.7	2.3	2.4	1.6
Medication: Ibuprofen	1.2	1.4	1.8	1.1	1.3	1.1
Loneliness, isolation	1.2	1.6	2.5	1.4	1.6	0.5
Fasting Glucose	1.1	1.3	1.5	1.1	1.0	1.2
Waist Hip Ratio (WHR)	1.1	5.0	7.0	2.0	2.0	2.7
Hand grip strength (right)	1.1	3.1	4.5	2.0	2.1	0.8
Alcohol intake versus 10 years previously	1.1	1.6	2.5	1.6	1.5	0.5
Father’s age at death	1.1	1.4	1.8	-1.3	-1.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	1.7	1.1	1.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	4.4	2.0	2.1	1.5
Ever highly irritable/argumentative for 2 days	1.1	1.3	1.5	1.2	1.2	1.0
Hearing aid user	1.1	1.2	2.3	0.8	0.8	1.5
Chronic bronchitis/emphysema (father)	1.0	1.1	1.4	1.1	1.2	0.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	3.6	-0.9	-0.8	-1.9
Commuting to job workplace: Public transport	1.0	1.2	2.0	0.9	0.9	1.4
LDL Cholesterol	0.9	1.4	2.3	-1.2	-0.6	-1.5
Neuroticism	0.9	2.2	2.4	1.6	1.5	1.3
Trunk fat mass	0.9	3.8	6.0	1.7	1.6	2.5
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.2	1.5	0.8	0.3
Pulse wave peak to peak time	0.9	1.1	1.8	1.2	1.3	0.4
Number of full sisters	0.9	1.1	1.4	1.2	1.0	0.9
Supplements: Zinc	0.8	0.9	1.2	1.1	0.7	1.0
Mouth/teeth dental problems	0.8	1.2	1.9	-1.4	-1.2	-0.5
Illnesses of mother	0.8	0.9	1.3	0.8	0.9	1.1
Medication for pain relief, constipation, heartburn	0.8	1.4	1.6	-1.1	-1.2	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.6	-0.6	-1.0	-1.3
Number of operations (self-reported)	0.8	1.1	1.5	1.2	0.8	1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	1.4	1.2	0.9	0.7
Irritable Bowel Disease (IBD)	0.7	1.7	2.7	-1.6	-1.4	-0.5
Prostate Cancer	0.7	1.0	1.8	1.3	1.0	0.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.5	1.2	0.9	0.6
Medication: Metformin	0.7	1.0	1.3	1.1	0.7	1.2
Maternal smoking around birth	0.7	1.0	1.7	1.3	0.9	0.8
Fluid intelligence score	0.7	1.5	1.9	-1.4	-1.4	-0.9
Hip circumference	0.7	3.0	3.2	1.8	1.7	1.6
Blood clot in the leg (DVT)	0.7	0.9	1.3	1.0	1.2	0.5
Medication: Paracetamol	0.7	1.2	1.7	1.2	1.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.4	1.2	0.9	0.4
Chest pain or discomfort	0.7	1.0	1.7	1.3	1.1	0.2
Qualifications: nursing, teaching	0.7	1.1	1.8	-0.8	-1.0	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.4	1.0	1.2	0.5
Bipolar Disorder or Schizophrenia	0.6	1.4	1.7	-1.3	-1.1	-1.2
Reaction Time	0.6	1.1	1.4	0.6	1.2	1.2
Primary Biliary Cirrhosis	0.6	0.9	1.4	-1.0	-1.2	-0.5
Medication: Co-codamol	0.6	0.7	1.1	-1.0	-0.9	-0.2
Waist circumference	0.6	2.2	3.0	1.4	1.3	1.7
Forced vital capacity (FVC)	0.6	2.2	3.0	1.7	1.7	0.8
Neuroticism score	0.6	1.3	1.6	1.2	1.3	0.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	2.4	1.5	1.5	1.3
Birth weight of first child	0.6	1.1	1.3	1.1	1.1	0.9
Number of full brothers	0.6	0.7	2.1	-0.0	-0.2	-1.5
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.1	1.0	1.0	0.5
Mood swings	0.6	1.0	2.7	-0.4	-0.5	-1.7
Illnesses of father: None of the above (group 1)	0.6	0.8	2.2	0.2	0.4	1.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	0.8	0.9	0.9	0.7
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	0.6	0.7	1.2
Medication: Blood pressure	0.6	1.2	1.3	-1.1	-1.0	-1.1
Risk taking	0.6	0.8	1.0	0.8	1.0	0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.2	1.1	1.0	0.0
Basal cell carcinoma (self-reported)	0.6	0.7	0.8	0.9	0.6	-0.9
Crohns Disease (2017)	0.5	1.2	1.9	-1.4	-1.3	-0.1
Ulcerative Colitis (UC)	0.5	1.0	1.5	-1.2	-1.0	-0.6
Mean Putamen Volume	0.5	0.5	1.1	0.7	1.1	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	0.4	0.7	1.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.9	0.6	0.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	0.6	0.8	0.8	0.8
Medication: Cholesterol lowering	0.5	0.8	1.1	-0.9	-1.1	0.7
Gout (self-reported)	0.5	0.7	1.5	-0.6	-0.6	-1.2
Medication: Amlodipine	0.5	0.6	1.8	-0.3	-0.1	-1.3
Number of children fathered	0.5	0.6	0.6	-0.7	-0.8	-0.8
Health satisfaction	0.5	0.7	1.0	0.9	1.0	0.3
Migraine (self-reported)	0.5	0.7	1.2	0.5	0.7	1.1
Whole body fat mass	0.5	2.3	4.2	1.1	1.1	2.1
Leg fat mass (right)	0.5	1.8	3.6	0.9	0.9	1.9
Overall health rating	0.5	1.1	1.4	1.0	1.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.8	0.9	0.9	-0.5
Knee pain experienced in last month	0.5	0.8	1.3	0.8	0.7	1.2
Diabetes diagnosed by doctor	0.5	0.8	1.5	0.9	0.6	1.2
Back pain experienced in last month	0.5	0.7	1.5	0.7	0.4	1.2
Breast cancer (self-reported)	0.5	0.5	1.0	-0.8	-1.0	0.0
Medication: Gliclazide	0.5	0.6	0.9	1.0	0.4	0.8
Medication: Bendroflumethiazide	0.5	0.8	1.2	0.9	1.1	0.5
Ever depressed for a whole week	0.5	0.7	1.3	1.1	0.8	0.3
Myopia	0.5	0.7	1.3	0.8	0.4	1.1
Depressed Affect (Nagel 2018)	0.4	0.9	1.1	1.1	1.0	0.7
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.4	-1.2	-1.1	-0.7
Blood Eosinophil Count	0.4	2.8	3.5	-1.3	-1.8	-1.9
Hypothyroidism (self reported)	0.4	0.9	1.6	-0.5	-0.9	-1.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.0	0.8	0.6	1.0
Hand grip strength (left)	0.4	1.0	1.6	1.1	1.2	0.1
Number of treatments/medications taken	0.4	0.7	0.8	0.7	0.8	0.9
Townsend deprivation index at recruitment	0.4	0.5	0.7	0.7	0.5	-0.9
Average weekly fortified wine intake	0.4	0.5	0.8	-0.5	-0.7	-0.9
Stomach or abdominal pain in last month	0.4	0.6	1.5	-0.4	-0.2	-1.2
Past tobacco smoking	0.4	0.6	1.5	0.1	0.7	1.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-0.3	-0.5	-1.1
Medication: Ramipril	0.4	0.5	0.8	0.9	0.5	0.8
Worrier / anxious feelings	0.4	0.7	1.0	-1.0	-0.9	-0.5
Falls in the last year	0.4	0.5	0.8	-0.9	-0.8	-0.4
Hair/balding pattern: Pattern 3	0.4	0.6	0.7	0.7	0.8	0.7
Pulse rate	0.4	0.6	1.6	0.5	0.3	1.3
Medication: Omeprazole	0.4	0.5	1.3	0.0	-0.1	-1.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.5	-0.6	-0.6	-0.7
Medication: Aspirin	0.4	0.5	0.6	0.5	0.7	0.8
Supplements: Calcium	0.4	0.4	0.7	0.9	0.5	-0.5
Leg fat mass (left)	0.4	1.5	3.1	0.9	0.8	1.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.3	-1.1	-1.1	-0.6
Alzheimer’s Disease (in father)	0.3	0.4	0.8	-0.6	-0.9	-0.2
HDL Cholesterol	0.3	0.5	0.7	-0.4	-0.8	-0.8
Tanning	0.3	3.2	3.6	-1.9	-1.7	-1.8
Systolic blood pressure, automated reading	0.3	0.7	1.4	0.6	0.7	1.2
Trunk fat percentage	0.3	1.3	3.4	0.5	0.5	1.8
Had other major operations	0.3	0.4	0.6	-0.8	-0.8	-0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.5	0.7	0.6	-0.5
Impedance of arm (right)	0.3	1.3	2.2	-1.5	-1.3	-0.1
Breastfed as a baby	0.3	0.3	0.7	-0.4	-0.4	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.7	1.0	0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.8	0.3	-0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.7	0.9	0.8	-0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.7	0.9	0.5	-0.0
Age at first live birth	0.3	0.5	0.8	-0.5	-0.7	-0.9
Illnesses of father: Heart disease	0.3	0.4	0.4	-0.6	-0.7	-0.6
Smoking status: Previous	0.3	0.4	0.6	-0.2	-0.7	-0.7
Arm fat mass (left)	0.3	1.1	1.9	0.8	0.8	1.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.4	0.3	0.9
Medication: Paracetamol	0.3	0.5	0.9	0.8	0.9	-0.0
Illnesses of father: High blood pressure	0.3	0.3	1.0	0.0	0.1	-1.0
Alcohol drinker status: Never	0.3	0.4	0.8	-0.5	-0.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.5	-0.7	-0.7	-0.3
Alcohol drinker status: Previous	0.3	0.4	0.5	-0.7	-0.5	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.2	0.0	0.9
Coronary Artery Disease (CAD)	0.2	0.3	0.8	-0.1	-0.1	0.9
Crohns Disease (2012)	0.2	0.3	0.4	-0.7	-0.6	-0.2
BMI	0.2	0.9	1.2	-1.1	-1.1	-0.7
Systolic Blood Pressure	0.2	1.1	1.7	0.8	1.3	0.9
Cardiovascular Disease	0.2	0.6	1.1	-1.1	-0.7	0.2
Pack years adult smoking proportion	0.2	0.3	0.7	-0.2	-0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	0.7	0.7	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.6	0.4	0.1	0.7
Medication: Atenolol	0.2	0.3	0.4	0.4	0.5	0.6
Had menopause	0.2	0.2	0.3	-0.3	-0.6	0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.6	0.5	0.2
Qualifications: None of the above	0.2	0.4	1.1	-0.4	-0.1	1.0
Allergy	0.2	0.4	0.6	-0.6	-0.3	0.8
Pain all over the body in last month	0.2	0.2	0.4	-0.3	-0.4	-0.6
Arm fat percentage (right)	0.2	0.8	1.3	-1.1	-1.1	0.4
Happiness	0.2	0.2	0.4	0.5	0.6	-0.2
Lung cancer (father)	0.2	0.2	0.5	0.7	0.5	0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.5	-0.7	0.1
Arm fat mass (right)	0.2	0.7	1.4	0.7	0.6	1.2
Loud music exposure frequency	0.2	0.3	0.4	-0.5	-0.6	-0.4
Glaucoma (self-reported)	0.2	0.2	0.3	0.5	0.5	0.6
High blood pressure (siblings)	0.2	0.3	0.5	-0.7	-0.5	-0.2
Body fat percentage	0.2	0.8	2.4	-0.2	-0.1	1.6
Leg fat percentage (right)	0.2	0.8	2.3	-0.2	-0.2	1.5
Comparative body size at age 10	0.2	0.6	1.0	-0.3	-0.8	-1.0
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.4	-0.5	-0.7
Emphysema/chronic bronchitis	0.2	0.3	0.4	0.6	0.6	-0.2
Medication: Allopurinol	0.2	0.3	0.7	-0.3	-0.3	-0.8
Medication: Seretide 50 evohaler	0.2	0.3	0.4	-0.7	-0.4	-0.5
Pulse rate, automated reading	0.2	0.7	1.0	1.0	0.9	0.6
Leg pain on walking	0.2	0.2	0.5	0.3	0.3	0.7
Supplements: Vitamin C	0.2	0.2	0.4	0.5	0.6	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	-0.5	-0.5	-0.2
Arm fat percentage (left)	0.2	0.7	1.1	-1.0	-1.0	0.4
Average weekly red wine intake	0.2	0.3	0.4	0.6	0.6	-0.5
Commuting to job workplace: Walk	0.2	0.2	0.5	0.4	0.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	0.2	0.7	0.7
Asthma (self-reported)	0.2	0.3	0.8	0.1	-0.3	-0.9
Smoking status: Current	0.2	0.3	0.7	0.3	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	0.6	0.5	0.7
Wears glasses or contact lenses	0.2	0.2	0.2	-0.4	-0.4	-0.4
Ever smoked	0.2	0.4	1.0	0.3	-0.1	-1.0
Leg fat percentage (left)	0.2	0.7	1.9	-0.4	-0.4	1.4
Average weekly beer plus cider intake	0.2	0.3	0.6	0.3	0.7	0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.6	0.5	-0.2	-0.8
Unable to work because of sickness or disability	0.2	0.3	0.8	0.3	0.2	-0.9
Pack years of smoking	0.2	0.3	0.7	-0.4	-0.2	-0.8
Neuroticism (Nagel 2018)	0.1	0.3	0.4	0.5	0.5	0.6
Breast Cancer	0.1	0.3	0.6	0.0	0.4	0.8
Ovarian Cancer	0.1	0.1	0.3	-0.1	-0.1	0.5
Age at First Birth	0.1	0.1	0.2	0.4	0.3	-0.1
Schizophrenia (2014)	0.1	0.2	0.3	-0.6	-0.5	-0.4
Triglycerides	0.1	0.1	0.2	0.2	0.4	0.5
Blood Red Count	0.1	1.4	1.6	1.1	1.2	1.2
Blood White Count	0.1	0.9	1.3	0.9	1.1	0.8
Heel T-Score	0.1	0.8	1.1	1.0	1.1	0.3
Allergy or Eczema	0.1	0.4	0.9	0.9	0.5	0.2
Lung FEV1/FVC ratio	0.1	0.3	0.8	0.5	0.2	0.9
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.1	0.1	0.5
Angina	0.1	0.1	0.2	-0.2	-0.1	-0.5
Diabetes (mother)	0.1	0.2	0.5	0.7	0.2	0.0
Impedance of leg (right)	0.1	0.5	1.4	-0.2	0.2	1.2
Current tobacco smoking	0.1	0.2	0.7	0.3	-0.0	-0.8
Age when periods started (menarche)	0.1	0.2	0.3	-0.5	-0.4	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.1	-0.3	-0.4	-0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.5	0.2	-0.3
High blood pressure	0.1	0.2	0.6	-0.2	-0.1	0.8
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.5	0.1	-0.7
Medication: Levothyroxine sodium	0.1	0.2	0.6	0.0	0.0	0.8
High blood pressure (mother)	0.1	0.1	0.3	0.2	0.1	-0.5
Impedance of leg (left)	0.1	0.4	1.0	-0.5	-0.2	1.0
Alcohol usually taken with meals	0.1	0.2	0.6	0.1	-0.1	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	0.2	0.4	-0.6
Heart attack	0.1	0.2	0.3	-0.5	-0.5	-0.1
Illnesses of siblings	0.1	0.2	0.3	-0.3	-0.4	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.2	-0.5	-0.2
Asthma	0.1	0.2	0.4	0.4	-0.1	-0.6
Medication: Lansoprazole	0.1	0.1	0.1	-0.3	-0.4	-0.2
Impedance of arm (left)	0.1	0.3	0.5	-0.7	-0.5	0.3
Length of working week for main job	0.1	0.1	0.3	0.1	-0.0	-0.6
Tense / ‘highly strung’	0.1	0.1	0.2	0.2	0.5	0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	-0.4	-0.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.5	-0.7	-0.1
Shortness of breath walking on level ground	0.1	0.1	0.1	0.4	0.4	0.0
Alcohol intake frequency.	0.1	0.2	0.4	-0.3	-0.3	-0.6
Suffer from ‘nerves’	0.1	0.2	0.4	0.5	0.6	0.1
Medication: Aspirin	0.1	0.1	0.2	0.2	0.3	0.4
Hypertension (Self-reported)	0.1	0.2	0.5	-0.3	-0.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.4	0.3	0.4
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.5	0.2	0.3
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	0.0	-0.1	0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.2	-0.4	-0.0
High cholesterol (Self-reported)	0.1	0.3	0.4	-0.6	-0.1	0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.2	-0.3	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	0.5	0.5	-0.4
Pain experienced in last month	0.1	0.2	0.3	-0.5	-0.5	-0.2
Impedance of whole body	0.1	0.5	0.9	-1.0	-0.6	0.4
Schizophrenia (2018)	0.0	0.0	0.0	-0.1	0.0	-0.1
Worry (Nagel 2018)	0.0	0.0	0.1	-0.0	0.0	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	-0.1
Ulcerative Colitis	0.0	0.0	0.1	-0.1	-0.2	0.3
Smoking Status	0.0	0.1	0.2	0.4	0.0	-0.2
Respiratory disease	0.0	0.1	0.2	0.2	-0.0	-0.5
Lung FVC	0.0	0.0	0.1	-0.3	-0.1	0.2
Hair Pigment	0.0	1.1	1.9	0.7	1.0	1.4
Sensitivity / hurt feelings	0.0	0.1	0.1	0.3	0.2	0.3
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	0.2	0.1	0.3
Fed-up feelings	0.0	0.1	0.1	-0.3	-0.1	-0.3
Taking other prescription medications	0.0	0.0	0.0	0.1	-0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.0	0.1	0.1	0.3	0.2	-0.0
Body mass index (BMI)	0.0	0.1	0.4	-0.1	-0.1	0.6
Nervous feelings	0.0	0.0	0.0	0.1	0.1	0.1
Diabetes (self-reported)	0.0	0.1	0.1	0.4	-0.1	0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	-0.1	-0.3	-0.3
Headache pain in last month	0.0	0.0	0.0	-0.1	0.0	-0.0
Worry too long after embarrassment	0.0	0.0	0.1	-0.3	-0.0	-0.1
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	0.2	-0.1	-0.4
Qualifications: College or University degree	0.0	0.1	0.1	0.2	0.1	0.3
Medication: Blood pressure	0.0	0.0	0.0	-0.1	-0.1	0.0
Angina (self-reported)	0.0	0.0	0.1	-0.0	-0.0	-0.3
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.1	-0.2	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.0	0.0	-0.2
Mother’s age at death	0.0	0.0	0.0	0.0	-0.1	0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.2	0.5	0.3

Hub : Genes

PCNA

Models

Trait associations