Best TWAS P=8.62e-30 · Best GWAS P=2.77e-26 conditioned to 0.743
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PABPC1L | 0.17 | 0.16 | lasso | 1 | 0.15 | 8.0e-18 | 10.6 | -10.6 | 2.8e-26 | -1.00 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | YWHAB | 0.13 | 0.17 | lasso | 2 | 0.15 | 2.8e-12 | 10.5 | -10.5 | 6.3e-26 | -0.99 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Visceral Omentum | YWHAB | 0.19 | 0.07 | lasso | 4 | 0.05 | 1.1e-03 | 10.6 | -10.9 | 9.4e-28 | -0.99 | 0.01 | 0.99 | FALSE |
4 | GTEx | Adrenal Gland | PABPC1L | 0.32 | 0.07 | lasso | 8 | 0.07 | 1.9e-03 | 10.6 | -11.3 | 8.6e-30 | -0.88 | 0.01 | 0.94 | TRUE |
5 | GTEx | Adrenal Gland | YWHAB | 0.23 | 0.15 | lasso | 3 | 0.10 | 1.4e-04 | 10.5 | -10.5 | 1.4e-25 | -0.99 | 0.01 | 0.98 | FALSE |
6 | GTEx | Artery Aorta | PABPC1L | 0.14 | 0.10 | lasso | 3 | 0.09 | 1.1e-05 | 8.7 | 7.5 | 7.4e-14 | 0.69 | 0.29 | 0.08 | FALSE |
7 | GTEx | Artery Aorta | YWHAB | 0.29 | 0.17 | lasso | 5 | 0.15 | 1.3e-08 | 10.5 | -10.8 | 2.1e-27 | -0.98 | 0.01 | 0.99 | FALSE |
8 | GTEx | Artery Tibial | TOMM34 | 0.07 | 0.00 | enet | 13 | 0.00 | 1.5e-01 | -3.6 | 5.3 | 1.2e-07 | 0.12 | 0.06 | 0.24 | FALSE |
9 | GTEx | Artery Tibial | PABPC1L | 0.15 | 0.00 | enet | 34 | 0.00 | 2.3e-01 | -3.6 | 5.3 | 1.1e-07 | 0.17 | 0.10 | 0.03 | FALSE |
10 | GTEx | Artery Tibial | YWHAB | 0.17 | 0.15 | lasso | 3 | 0.16 | 3.5e-12 | 10.5 | -10.6 | 3.0e-26 | -0.99 | 0.01 | 0.99 | FALSE |
11 | GTEx | Brain Cerebellar Hemisphere | IFT52 | 0.32 | 0.15 | lasso | 3 | 0.13 | 4.0e-04 | 5.8 | -5.7 | 1.2e-08 | -0.04 | 0.29 | 0.27 | FALSE |
12 | GTEx | Brain Cerebellar Hemisphere | YWHAB | 0.42 | 0.22 | lasso | 4 | 0.18 | 2.3e-05 | 10.6 | -10.7 | 1.1e-26 | -0.99 | 0.01 | 0.98 | FALSE |
13 | GTEx | Brain Cerebellum | CTSA | 0.20 | 0.12 | lasso | 4 | 0.11 | 3.7e-04 | -5.7 | 5.8 | 6.7e-09 | -0.02 | 0.08 | 0.76 | FALSE |
14 | GTEx | Brain Cerebellum | IFT52 | 0.18 | 0.16 | lasso | 3 | 0.10 | 6.1e-04 | 5.7 | -5.7 | 1.1e-08 | -0.04 | 0.13 | 0.46 | FALSE |
15 | GTEx | Brain Cerebellum | YWHAB | 0.43 | 0.19 | lasso | 7 | 0.16 | 1.7e-05 | 10.6 | -10.6 | 2.6e-26 | -0.97 | 0.01 | 0.98 | FALSE |
16 | GTEx | Brain Cerebellum | RP3-337O18.9 | 0.14 | 0.11 | lasso | 3 | 0.10 | 9.4e-04 | -5.8 | 5.7 | 1.2e-08 | -0.02 | 0.06 | 0.82 | FALSE |
17 | GTEx | Brain Nucleus accumbens basal ganglia | YWHAB | 0.22 | 0.11 | lasso | 3 | 0.07 | 6.5e-03 | 10.6 | -10.3 | 7.0e-25 | -0.97 | 0.01 | 0.95 | FALSE |
18 | GTEx | Breast Mammary Tissue | YWHAB | 0.18 | 0.09 | lasso | 6 | 0.08 | 5.2e-05 | 10.6 | -10.0 | 1.8e-23 | -0.96 | 0.01 | 0.99 | FALSE |
19 | GTEx | Cells EBV-transformed lymphocytes | YWHAB | 0.27 | 0.12 | enet | 13 | 0.18 | 1.2e-06 | 9.4 | -10.0 | 1.0e-23 | -0.95 | 0.01 | 0.99 | FALSE |
20 | GTEx | Cells Transformed fibroblasts | PABPC1L | 0.12 | 0.03 | enet | 22 | 0.08 | 2.0e-06 | 5.4 | 6.5 | 7.6e-11 | 0.71 | 0.09 | 0.91 | FALSE |
21 | GTEx | Cells Transformed fibroblasts | YWHAB | 0.29 | 0.20 | enet | 21 | 0.26 | 1.5e-19 | 10.6 | -8.8 | 1.3e-18 | -0.85 | 0.01 | 0.99 | FALSE |
22 | GTEx | Colon Sigmoid | YWHAB | 0.27 | 0.14 | lasso | 4 | 0.10 | 1.7e-04 | 10.6 | -9.6 | 7.8e-22 | -0.95 | 0.01 | 0.98 | FALSE |
23 | GTEx | Colon Sigmoid | ZSWIM1 | 0.28 | 0.13 | lasso | 2 | 0.14 | 1.8e-05 | -5.7 | -5.7 | 1.2e-08 | 0.06 | 0.04 | 0.94 | FALSE |
24 | GTEx | Esophagus Gastroesophageal Junction | YWHAB | 0.31 | 0.18 | lasso | 5 | 0.14 | 9.9e-06 | 10.4 | -10.6 | 2.3e-26 | -0.95 | 0.01 | 0.99 | FALSE |
25 | GTEx | Esophagus Mucosa | YWHAB | 0.25 | 0.27 | enet | 7 | 0.27 | 4.2e-18 | 10.5 | -10.6 | 2.2e-26 | -1.00 | 0.01 | 0.99 | FALSE |
26 | GTEx | Esophagus Muscularis | IFT52 | 0.19 | 0.09 | enet | 12 | 0.14 | 5.1e-09 | 7.1 | -5.5 | 4.9e-08 | -0.07 | 0.33 | 0.66 | FALSE |
27 | GTEx | Esophagus Muscularis | YWHAB | 0.16 | 0.11 | lasso | 3 | 0.14 | 1.5e-08 | 8.7 | -10.2 | 2.2e-24 | -0.93 | 0.02 | 0.98 | FALSE |
28 | GTEx | Heart Atrial Appendage | DNTTIP1 | 0.09 | 0.10 | lasso | 2 | 0.08 | 1.6e-04 | -5.8 | 5.6 | 2.4e-08 | -0.05 | 0.06 | 0.93 | FALSE |
29 | GTEx | Lung | YWHAB | 0.10 | 0.04 | lasso | 4 | 0.04 | 6.5e-04 | 10.5 | -10.3 | 5.0e-25 | -0.98 | 0.01 | 0.98 | FALSE |
30 | GTEx | Muscle Skeletal | YWHAB | 0.09 | 0.07 | lasso | 5 | 0.07 | 4.5e-07 | 10.6 | -10.7 | 6.0e-27 | -0.98 | 0.01 | 0.99 | FALSE |
31 | GTEx | Nerve Tibial | TOMM34 | 0.11 | 0.02 | lasso | 4 | 0.03 | 6.0e-03 | 5.4 | 6.3 | 2.5e-10 | 0.66 | 0.03 | 0.82 | FALSE |
32 | GTEx | Nerve Tibial | YWHAB | 0.21 | 0.24 | lasso | 2 | 0.23 | 3.3e-16 | 10.4 | -10.6 | 4.2e-26 | -0.94 | 0.01 | 0.99 | FALSE |
33 | GTEx | Skin Not Sun Exposed Suprapubic | YWHAB | 0.33 | 0.24 | lasso | 4 | 0.26 | 1.6e-14 | 10.6 | -10.1 | 4.5e-24 | -0.97 | 0.01 | 0.99 | FALSE |
34 | GTEx | Skin Sun Exposed Lower leg | YWHAB | 0.17 | 0.18 | lasso | 2 | 0.17 | 4.7e-14 | 10.5 | -10.5 | 6.2e-26 | -0.99 | 0.01 | 0.99 | FALSE |
35 | GTEx | Testis | YWHAB | 0.23 | 0.23 | enet | 14 | 0.23 | 1.8e-10 | 10.5 | -10.9 | 1.5e-27 | -0.96 | 0.01 | 0.99 | FALSE |
36 | GTEx | Testis | ZSWIM1 | 0.23 | 0.11 | lasso | 7 | 0.12 | 6.0e-06 | -5.7 | -6.0 | 2.2e-09 | 0.05 | 0.04 | 0.95 | FALSE |
37 | GTEx | Thyroid | SNX21 | 0.09 | 0.10 | lasso | 3 | 0.10 | 3.0e-08 | -5.8 | 5.8 | 5.1e-09 | -0.06 | 0.03 | 0.97 | FALSE |
38 | GTEx | Thyroid | YWHAB | 0.22 | 0.18 | lasso | 2 | 0.17 | 5.3e-13 | 10.5 | -10.5 | 6.0e-26 | -0.99 | 0.01 | 0.99 | FALSE |
39 | GTEx | Whole Blood | YWHAB | 0.20 | 0.10 | lasso | 9 | 0.10 | 1.6e-09 | 10.6 | -10.2 | 1.4e-24 | -0.98 | 0.01 | 0.99 | FALSE |
40 | METSIM | Adipose | MYBL2 | 0.11 | 0.08 | lasso | 3 | 0.07 | 1.1e-10 | 4.4 | 5.9 | 3.1e-09 | 0.11 | 0.44 | 0.56 | TRUE |
41 | METSIM | Adipose | SLPI | 0.05 | 0.01 | lasso | 7 | 0.02 | 1.0e-03 | -8.8 | -7.7 | 1.0e-14 | -0.03 | 0.51 | 0.02 | TRUE |
42 | NTR | Blood | TOMM34 | 0.03 | 0.01 | bslmm | 417 | 0.01 | 2.0e-03 | -4.7 | 6.6 | 5.5e-11 | 0.42 | 0.36 | 0.16 | FALSE |
43 | NTR | Blood | YWHAB | 0.16 | 0.19 | lasso | 5 | 0.19 | 2.2e-58 | 10.6 | -10.6 | 2.8e-26 | -1.00 | 0.01 | 0.99 | FALSE |
44 | ROSMAP | Brain Pre-frontal Cortex | PABPC1L | 0.24 | 0.21 | lasso | 3 | 0.21 | 8.1e-27 | 10.6 | -9.9 | 2.8e-23 | -0.98 | 0.00 | 1.00 | FALSE |
45 | ROSMAP | Brain Pre-frontal Cortex | YWHAB | 0.56 | 0.58 | bslmm | 418 | 0.59 | 7.7e-94 | 10.5 | -10.7 | 1.7e-26 | -0.99 | 0.01 | 0.99 | FALSE |
46 | YFS | Blood | CTSA | 0.03 | 0.02 | lasso | 5 | 0.01 | 4.1e-04 | -5.7 | 6.0 | 1.9e-09 | -0.07 | 0.05 | 0.94 | TRUE |
47 | YFS | Blood | PABPC1L | 0.17 | 0.13 | enet | 41 | 0.14 | 1.8e-43 | 8.7 | 6.9 | 6.3e-12 | 0.78 | 1.00 | 0.00 | FALSE |
48 | YFS | Blood | YWHAB | 0.07 | 0.06 | lasso | 4 | 0.07 | 6.8e-21 | 10.4 | 10.7 | 6.8e-27 | 0.95 | 0.03 | 0.97 | FALSE |
49 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PABPC1L | 0.02 | 0.02 | lasso | 4 | 0.02 | 2.2e-04 | 10.6 | -10.6 | 3.3e-26 | -1.00 | 0.00 | 0.99 | FALSE |
50 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZSWIM1 | 0.01 | 0.01 | blup | 41 | 0.01 | 2.4e-02 | -5.7 | -5.9 | 3.8e-09 | 0.04 | 0.03 | 0.90 | FALSE |
51 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ZSWIM1 | 0.06 | 0.02 | blup | 42 | 0.04 | 5.8e-03 | -5.8 | -5.4 | 6.2e-08 | 0.05 | 0.02 | 0.72 | FALSE |
52 | The Cancer Genome Atlas | Colon Adenocarcinoma | PABPC1L | 0.08 | 0.01 | enet | 8 | 0.02 | 3.6e-02 | 10.6 | -7.2 | 5.7e-13 | -0.77 | 0.01 | 0.87 | FALSE |
53 | The Cancer Genome Atlas | Esophageal Carcinoma | YWHAB | 0.15 | 0.14 | lasso | 5 | 0.10 | 4.6e-04 | 9.4 | -9.8 | 1.6e-22 | -0.86 | 0.02 | 0.89 | FALSE |
54 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PABPC1L | 0.20 | 0.21 | lasso | 3 | 0.21 | 5.5e-23 | 10.6 | -10.6 | 3.1e-26 | -1.00 | 0.00 | 1.00 | FALSE |
55 | The Cancer Genome Atlas | Brain Lower Grade Glioma | YWHAB | 0.06 | 0.07 | enet | 6 | 0.09 | 7.4e-11 | 8.7 | -10.1 | 3.9e-24 | -0.93 | 0.02 | 0.98 | FALSE |
56 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZSWIM1 | 0.04 | 0.07 | lasso | 4 | 0.07 | 3.1e-08 | -5.7 | -5.6 | 2.5e-08 | 0.06 | 0.03 | 0.97 | FALSE |
57 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | YWHAB | 0.04 | 0.03 | lasso | 5 | 0.04 | 2.9e-05 | 10.4 | -10.7 | 1.1e-26 | -0.93 | 0.01 | 0.98 | FALSE |
58 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | YWHAB | 0.07 | 0.06 | lasso | 2 | 0.06 | 1.3e-04 | 10.6 | -10.5 | 5.4e-26 | -0.99 | 0.01 | 0.97 | FALSE |
59 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | YWHAB | 0.16 | -0.01 | blup | 52 | 0.03 | 2.1e-02 | -4.6 | -7.7 | 1.4e-14 | -0.71 | 0.01 | 0.62 | FALSE |
60 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PABPC1L | 0.08 | 0.14 | lasso | 4 | 0.14 | 4.2e-14 | 10.6 | -10.6 | 3.1e-26 | -1.00 | 0.01 | 0.99 | FALSE |
61 | The Cancer Genome Atlas | Prostate Adenocarcinoma | STK4 | 0.06 | 0.01 | blup | 88 | 0.02 | 4.9e-03 | -9.0 | 5.6 | 1.9e-08 | 0.10 | 0.01 | 0.95 | FALSE |
62 | The Cancer Genome Atlas | Prostate Adenocarcinoma | YWHAB | 0.07 | 0.06 | lasso | 6 | 0.06 | 3.1e-07 | 10.6 | -10.7 | 1.1e-26 | -0.97 | 0.01 | 0.99 | FALSE |
63 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZSWIM1 | 0.04 | 0.07 | blup | 41 | 0.05 | 4.3e-06 | -5.2 | -5.6 | 2.5e-08 | 0.04 | 0.03 | 0.97 | FALSE |
64 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZSWIM3 | 0.02 | 0.03 | lasso | 2 | 0.02 | 1.7e-03 | -5.7 | -5.7 | 1.3e-08 | 0.03 | 0.02 | 0.82 | FALSE |
65 | The Cancer Genome Atlas | Stomach Adenocarcinoma | YWHAB | 0.04 | 0.05 | enet | 10 | 0.03 | 2.3e-03 | 9.4 | -10.3 | 6.3e-25 | -0.89 | 0.01 | 0.92 | FALSE |
66 | The Cancer Genome Atlas | Thyroid Carcinoma | YWHAB | 0.12 | 0.13 | lasso | 5 | 0.12 | 4.3e-12 | 10.6 | -10.5 | 7.1e-26 | -1.00 | 0.00 | 1.00 | FALSE |