Hub : Genes

SLPI

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.2560 0.0550 1.7e-12 0.186 NA 0.242 NA 0.232 1.6e-12 NA 3.2e-16 NA 1.5e-15
2 GTEx Heart Atrial Appendage 0.6600 0.0850 1.3e-05 0.002 NA 0.009 NA -0.001 2.6e-01 NA 1.2e-01 NA 3.6e-01
3 GTEx Skin Not Sun Exposed Suprapubic 0.3310 0.0840 7.1e-07 0.092 NA 0.094 NA 0.086 9.2e-06 NA 8.2e-06 NA 1.9e-05
4 GTEx Skin Sun Exposed Lower leg 0.2120 0.0510 3.1e-10 0.136 NA 0.123 NA 0.136 2.3e-11 NA 2.3e-10 NA 2.2e-11
5 METSIM Adipose 0.0454 0.0213 4.1e-03 0.014 0.013 0.015 0.017 0.017 3.3e-03 3.4e-03 2.2e-03 0.0012 1.0e-03
6 NTR Blood 0.0195 0.0092 5.8e-03 0.004 0.001 0.000 0.004 0.003 1.4e-02 1.8e-01 2.1e-01 0.0110 4.1e-02
7 TCGA Head and Neck Squamous Cell Carcinoma 0.0341 0.0181 1.7e-04 0.046 0.038 0.036 NA 0.044 6.3e-06 4.1e-05 6.3e-05 NA 1.1e-05
8 TCGA Brain Lower Grade Glioma 0.0646 0.0410 1.0e-03 0.009 0.026 0.026 NA 0.017 3.0e-02 4.8e-04 5.7e-04 NA 4.2e-03
9 TCGA Ovarian Serous Cystadenocarcinoma 0.0610 0.0350 1.8e-03 0.001 0.018 0.033 NA 0.023 2.5e-01 2.0e-02 2.7e-03 NA 1.1e-02
10 TCGA Prostate Adenocarcinoma 0.0321 0.0167 1.4e-04 0.037 0.034 0.022 NA 0.039 8.6e-05 1.6e-04 1.9e-03 NA 6.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 6.3 10.0 16.3 -3.9 0.0 -4.0 -3.5 0.5 2.6 -4.0 2.9 -3.2 -3.8
Bipolar Disorder or Schizophrenia 1.6 4.0 8.5 -2.1 0.0 -2.5 -1.8 0.4 2.9 -2.4 1.8 -2.2 -2.0
Depressed Affect (Nagel 2018) 0.3 0.6 1.6 -0.8 0.0 -0.6 -0.9 1.3 -0.2 -0.5 0.6 1.0 -1.1
Depression (Nagel 2018) 0.5 0.7 3.0 0.6 0.0 0.3 0.3 0.0 -1.3 0.7 -1.0 1.7 0.4
Intelligence (Savage-Jansen 2018) 0.8 2.5 7.5 -1.6 0.0 -2.7 -1.8 2.3 0.2 -1.6 0.5 0.1 -1.8
Neuroticism (Nagel 2018) 0.9 2.0 4.7 -1.4 0.0 -1.3 -1.7 2.2 -0.9 -1.1 1.5 1.4 -1.6
Schizophrenia (2018) 0.2 0.3 2.6 0.5 0.0 -0.1 0.4 0.1 1.6 0.2 0.0 -0.2 0.6
Schizophrenia vs Biploar Disorder 5.5 7.3 14.3 3.4 0.0 3.2 3.5 0.2 -0.6 3.8 -3.3 1.0 3.4
Worry (Nagel 2018) 0.2 0.4 1.1 -0.4 0.0 -0.3 -0.5 1.0 -0.6 -0.1 1.0 0.7 -0.4
Alzheimer’s Disease (in mother) 2.3 2.7 6.8 2.0 0.0 1.3 1.8 2.2 1.1 1.4 -2.6 -0.3 1.7
Alzheimer’s Disease (in father) 3.4 3.7 6.6 -2.6 0.0 -1.0 -2.4 2.6 1.0 -2.5 1.9 -1.0 -2.5
Alzheimer’s Disease (including proxy) 1.1 1.5 9.9 0.2 0.0 0.6 0.3 3.1 1.7 -0.1 -1.0 -1.1 0.2
Crohns Disease (2017) 0.4 0.9 2.4 0.7 0.0 0.4 1.5 -0.2 0.5 1.4 -0.8 -1.5 0.8
Irritable Bowel Disease (IBD) 0.1 0.3 1.0 0.3 0.0 0.1 0.9 -0.4 0.5 1.0 -0.1 -0.8 0.2
Ulcerative Colitis (UC) 0.1 0.2 0.8 -0.3 0.0 -0.7 -0.2 -0.3 -0.1 -0.0 0.9 0.2 -0.6
Major Depression (MDD) 0.5 0.6 2.1 -0.4 0.0 -0.6 -0.6 -1.5 -1.3 0.0 0.3 0.5 -0.7
Reaction Time 0.4 0.8 1.8 -1.3 0.0 -0.4 -0.8 0.1 -0.9 -0.8 1.0 -1.3 -0.9
Verbal and Numeric Reasoning (VNR) 1.4 3.4 10.8 -1.7 0.0 -3.3 -2.1 2.3 0.9 -2.1 0.7 0.0 -2.2
Breast Cancer 1.3 3.1 7.7 -2.4 0.0 -1.1 -2.5 0.8 0.4 -2.8 1.6 -0.6 -2.5
Ovarian Cancer 0.3 0.4 1.5 -0.1 0.0 1.0 0.1 -1.1 -0.2 -0.1 -0.5 -1.2 -0.2
Prostate Cancer 0.2 0.3 1.3 -0.2 0.0 -1.2 -0.2 -0.2 -1.0 0.1 -0.5 0.3 0.1
Age at First Birth 0.3 0.5 1.7 -0.8 0.0 -0.8 -0.6 0.7 0.6 -0.3 1.3 0.4 -0.6
Bipolar Disorder (2011) 4.3 4.2 8.6 -2.8 0.0 -2.5 -2.1 0.3 1.7 -2.0 2.0 -1.9 -2.9
Body Mass Index (BMI) (2010) 1.4 1.9 3.8 1.7 0.0 1.0 1.5 0.8 -0.8 1.7 -1.9 1.2 1.9
Coronary Artery Disease (CAD) 1.3 1.6 3.9 1.4 0.0 2.0 1.7 -1.0 0.3 1.7 -0.9 -0.3 1.7
Crohns Disease (2012) 1.1 1.8 4.2 1.0 0.0 1.0 2.0 -0.9 0.6 1.7 -1.5 -2.0 1.4
Mean Putamen Volume 0.2 0.3 0.8 0.1 0.0 0.5 -0.3 -0.9 -0.6 -0.2 0.5 0.9 -0.1
Fasting Glucose 0.3 0.3 1.1 -0.4 0.0 -0.5 -0.5 0.7 0.5 -0.5 1.1 0.1 -0.6
HbA1C 1.2 1.3 3.7 -1.2 0.0 -0.9 -1.9 1.0 -0.4 -1.7 0.6 0.6 -1.7
HDL Cholesterol 0.3 0.4 1.4 -0.8 0.0 -0.6 -0.3 0.2 0.7 -0.5 0.7 -1.2 -0.9
LDL Cholesterol 0.9 1.4 4.3 -1.1 0.0 -2.1 -1.5 -1.4 0.0 -1.1 1.2 0.4 -1.3
Lupus 0.2 0.3 1.1 0.7 0.0 -0.1 0.7 -0.1 0.7 1.0 0.1 -0.1 0.5
Neuroticism (2016) 0.7 1.1 8.3 0.2 0.0 -0.3 -0.3 2.9 0.7 -0.3 0.1 1.3 -0.3
Primary Biliary Cirrhosis 0.2 0.3 1.1 -0.3 0.0 -0.0 -0.1 -0.2 1.0 -0.7 0.6 -0.8 -0.1
Rheumatoid Arthritis 0.9 1.3 2.7 1.6 0.0 1.1 1.4 -0.1 0.7 1.6 -1.2 0.4 1.6
Schizophrenia (2014) 0.3 0.6 2.4 0.5 0.0 0.5 0.8 -0.7 1.6 0.5 -0.1 -1.2 0.8
Triglycerides 1.1 1.8 4.6 1.5 0.0 1.6 1.4 -2.1 1.4 1.4 -0.3 -0.3 1.4
Type 2 Diabetes (T2D) (2012) 1.2 1.3 5.2 -0.6 0.0 -0.7 -0.8 -1.9 -0.9 -1.2 2.3 0.1 -0.8
Ulcerative Colitis 0.1 0.2 0.4 -0.0 0.0 0.3 0.3 -0.5 0.6 0.1 0.6 -0.6 -0.1
Blood Eosinophil Count 0.8 6.4 11.5 -3.4 0.0 -3.1 -3.0 -1.1 1.5 -3.4 2.0 -2.1 -3.3
Blood Platelet Count 0.5 6.3 26.8 2.2 0.0 1.0 2.6 -5.2 3.0 1.9 -0.8 -1.6 2.8
Blood Red Count 0.1 1.0 2.6 -0.7 0.0 -1.6 -0.3 0.9 1.5 -0.7 -0.5 -1.6 -0.6
Blood White Count 0.4 2.7 12.9 -1.4 0.0 -0.1 -1.1 0.4 3.6 -1.5 1.3 -2.1 -1.7
Heel T-Score 0.2 1.4 7.2 0.8 0.0 -0.6 1.0 -2.7 1.1 1.3 0.1 -0.9 1.1
BMI 0.1 0.5 3.0 0.4 0.0 0.8 0.2 1.7 0.1 -0.2 -1.0 0.6 0.2
Height 0.4 7.9 59.8 1.3 0.0 2.7 1.6 -7.7 -1.3 1.7 1.4 0.1 1.3
Waist Hip Ratio (WHR) 0.6 2.7 5.7 2.4 0.0 1.7 2.1 -1.1 1.7 2.0 -1.6 0.3 1.9
Systolic Blood Pressure 0.3 1.5 3.7 1.8 0.0 -0.1 1.5 -0.8 1.3 1.9 -0.9 0.8 1.5
Smoking Status 0.6 1.3 9.7 0.9 0.0 -0.4 -0.1 0.2 -1.5 0.3 -0.1 3.1 0.4
Allergy or Eczema 0.5 1.4 5.1 -0.6 0.0 -2.2 -1.3 0.3 -1.7 -1.1 0.1 1.3 -1.0
Cardiovascular Disease 0.2 0.7 1.8 -0.3 0.0 -0.2 -0.9 1.3 0.4 -0.7 1.3 1.1 -0.8
Hypothyroidism (self reported) 0.9 2.0 6.0 -1.2 0.0 -2.4 -1.5 1.5 -1.8 -1.5 0.3 0.8 -1.4
Respiratory disease 0.5 1.1 3.0 -0.9 0.0 -1.2 -0.5 0.1 1.5 -1.0 1.1 -1.7 -1.0
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.7 0.1 0.0 0.7 0.0 -0.5 -0.6 -0.2 -0.1 0.8 0.3
Lung FEV1/FVC ratio 0.4 2.0 10.6 1.2 0.0 1.4 0.9 -0.2 3.3 0.4 -1.8 -0.6 1.0
Lung FVC 0.1 0.7 2.9 0.6 0.0 -0.7 0.5 0.7 -1.7 0.8 -0.7 0.6 0.9
Neuroticism 0.4 1.0 4.0 -0.6 0.0 -1.0 -0.8 2.0 -0.7 -0.4 0.3 1.7 -0.6
Chronotype (morning person) 0.5 1.2 3.4 1.4 0.0 0.9 1.2 -0.6 -0.7 1.1 -1.8 1.0 1.2
Hair Pigment 0.0 0.4 1.4 1.2 0.0 0.5 0.6 0.1 -0.3 0.6 0.0 1.1 0.7
Tanning 0.1 0.8 3.0 -0.2 0.0 -0.8 -0.7 -1.7 -1.4 -0.6 0.3 1.1 -0.3
Hand grip strength (left) 0.6 1.6 9.2 -1.0 0.0 -3.0 -1.2 0.5 0.7 -0.7 1.2 0.5 -1.1
Number of treatments/medications taken 0.3 0.5 1.8 0.0 0.0 -0.5 -0.6 0.8 -0.7 -0.7 0.9 1.4 -0.6
Average weekly spirits intake 3.1 3.9 7.2 -2.7 0.0 -2.0 -2.3 2.6 1.6 -2.2 1.1 -1.2 -2.4
Sensitivity / hurt feelings 0.6 1.0 7.1 -0.1 0.0 0.3 -0.4 2.7 -0.7 -0.4 0.2 1.6 0.0
Frequency of depressed mood in last 2 weeks 0.7 0.9 5.1 0.8 0.0 0.5 0.2 0.3 -1.4 0.8 -0.6 2.2 0.6
Hearing difficulty/problems: Yes 0.2 0.3 1.4 -0.5 0.0 -0.6 -0.4 1.2 -0.5 -0.2 -0.1 0.1 -0.4
Relative age of first facial hair 0.1 0.3 0.8 0.2 0.0 0.1 0.5 -0.7 0.7 0.4 -0.9 -0.2 0.6
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 5.0 2.2 0.0 1.8 1.6 1.9 -1.1 2.1 -1.9 2.2 1.8
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.2 -1.8 0.0 0.1 -1.1 -0.7 1.1 -1.1 1.1 -1.5 -1.5
Ever had hysterectomy (womb removed) 0.8 0.9 2.8 0.4 0.0 1.3 0.8 -0.4 1.7 0.4 -1.3 -1.3 0.5
Systolic blood pressure, automated reading 1.4 4.0 11.0 2.6 0.0 1.2 2.6 0.2 -0.4 3.3 -2.0 1.3 2.9
Eye problems/disorders: Diabetes related eye disease 1.1 1.3 7.2 1.1 0.0 1.0 0.9 -2.7 -0.4 1.1 -0.1 0.7 0.8
Angina 0.3 0.3 1.7 0.6 0.0 0.6 0.1 0.1 -0.7 0.4 -0.4 1.3 0.2
Medication for hormone replacement therapy 0.3 0.3 1.4 -0.1 0.0 1.2 0.1 -0.3 0.8 0.2 1.0 -0.5 0.0
Vitamin and mineral supplements 0.3 0.4 1.3 0.5 0.0 0.6 0.6 -0.9 1.2 0.5 0.1 -0.5 0.6
Supplements: Zinc 0.2 0.2 0.4 -0.6 0.0 -0.2 -0.5 -0.6 -0.6 -0.3 -0.1 0.2 -0.5
Medication: Co-codamol 0.1 0.1 0.6 -0.1 0.0 0.5 -0.1 -0.2 0.8 -0.0 0.4 -0.3 -0.2
Medication: Metformin 1.1 1.6 5.3 1.2 0.0 1.6 1.1 -2.3 -0.5 0.9 -1.1 1.2 1.3
Diabetes (father) 1.1 1.3 3.0 -1.3 0.0 -0.8 -1.6 0.5 0.5 -1.7 1.4 -0.2 -1.6
Diabetes (mother) 0.4 0.6 5.0 -0.2 0.0 0.2 0.1 -2.2 0.0 0.1 -0.5 -0.5 0.3
Severe depression (siblings) 1.1 1.2 3.0 -1.0 0.0 -1.7 -1.0 -0.8 0.9 -0.8 1.7 -0.6 -1.2
Pack years adult smoking proportion 0.6 1.0 3.0 0.7 0.0 1.1 0.5 1.7 0.6 0.7 -1.7 0.7 0.7
Impedance of leg (right) 0.5 2.6 5.5 -1.9 0.0 -2.3 -1.7 0.1 1.2 -1.3 2.2 -1.5 -2.0
Leg fat-free mass (left) 0.4 2.0 9.4 1.4 0.0 1.7 1.2 -3.1 -0.6 1.0 -0.8 0.9 1.1
Trunk fat percentage 0.2 0.8 2.1 1.2 0.0 1.4 1.1 -0.6 0.6 0.8 -0.8 0.2 0.8
Hand grip strength (right) 0.7 2.0 6.1 -1.5 0.0 -2.5 -1.6 1.8 0.0 -1.2 1.5 0.6 -1.5
Townsend deprivation index at recruitment 2.0 2.8 13.5 0.5 0.0 0.4 -0.7 -1.0 -3.7 -0.2 0.7 3.4 0.3
Current tobacco smoking 0.2 0.3 1.5 0.3 0.0 0.5 0.0 -0.8 0.1 0.3 -0.4 1.2 0.2
Average weekly fortified wine intake 1.4 1.7 6.7 0.2 0.0 1.7 1.0 0.1 2.6 0.3 -1.1 -2.1 0.6
Maternal smoking around birth 0.3 0.5 1.3 0.1 0.0 1.0 0.2 -0.5 -0.8 0.7 -1.1 1.1 0.5
Fed-up feelings 1.0 1.8 6.1 -1.6 0.0 -0.9 -1.6 2.5 0.7 -1.4 0.7 0.2 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 5.4 1.7 0.0 1.7 1.2 -0.6 -0.6 1.4 -1.6 2.3 1.5
Relative age voice broke 0.3 0.5 2.3 0.1 0.0 1.0 0.5 0.3 1.5 0.6 -0.8 -0.7 0.3
Taking other prescription medications 0.2 0.3 1.2 0.1 0.0 0.8 -0.1 0.7 -1.1 0.3 0.1 0.6 -0.3
Age when periods started (menarche) 1.0 2.3 4.3 -2.1 0.0 -1.4 -2.0 1.7 -0.2 -2.0 1.4 -0.9 -1.9
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 5.3 -0.0 0.0 0.5 0.7 0.5 2.3 0.4 -1.3 -2.0 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 9.7 2.0 0.0 0.6 2.2 -3.1 0.7 2.2 -1.3 -0.2 2.2
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.5 -1.2 0.0 -1.0 -0.9 -1.6 0.6 -1.3 0.4 -0.9 -0.9
Qualifications: CSEs or equivalent 0.5 0.6 2.3 -0.4 0.0 -0.0 -1.0 -0.8 -0.2 -0.6 1.5 0.9 -1.0
Serious illness, injury or assault to yourself 0.1 0.2 0.5 0.6 0.0 0.7 0.1 -0.3 -0.6 0.1 -0.1 0.7 0.2
High blood pressure 0.5 1.5 4.0 1.5 0.0 2.0 1.6 0.3 -0.2 1.6 -1.0 0.4 1.5
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.7 -0.0 0.0 -1.7 -0.7 -0.3 -1.4 -0.4 -0.0 1.6 -0.6
Multivitamins +/- minerals 1.4 1.8 3.7 -1.9 0.0 -1.3 -1.9 1.1 -0.9 -1.8 0.4 -0.0 -1.8
Stomach or abdominal pain in last month 0.4 0.6 2.1 0.8 0.0 0.4 0.6 1.4 0.9 0.5 -1.0 -0.0 0.4
Supplements: Glucosamine 1.2 1.5 4.3 -2.1 0.0 -1.4 -1.7 0.1 -0.4 -1.2 1.1 -0.7 -1.7
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 7.1 -0.4 0.0 0.8 0.4 0.3 2.7 0.2 -0.5 -2.6 -0.2
Medication: Atenolol 1.3 1.6 4.7 1.5 0.0 1.5 1.4 -2.2 -0.5 1.1 -1.2 0.9 1.3
Medication: Levothyroxine sodium 0.4 0.7 3.0 1.0 0.0 -0.2 0.4 -0.1 -1.7 0.7 0.1 1.4 0.5
Sitting height 0.1 0.5 3.4 0.1 0.0 1.0 0.2 -1.9 -0.1 0.1 0.7 -0.7 0.0
Chronic bronchitis/emphysema (father) 1.0 1.1 2.6 -0.8 0.0 -1.6 -1.0 1.1 -1.0 -0.9 1.6 1.0 -0.8
High blood pressure (mother) 0.2 0.3 1.0 1.0 0.0 0.2 0.6 0.6 -0.4 0.7 0.4 0.1 0.7
Body mass index (BMI) 0.3 1.1 2.2 1.5 0.0 1.3 1.2 0.1 0.2 1.1 -1.5 1.0 1.2
Impedance of leg (left) 0.4 1.9 3.7 -1.6 0.0 -1.9 -1.2 0.2 1.4 -0.8 1.8 -1.9 -1.6
Leg predicted mass (left) 0.3 1.9 9.2 1.4 0.0 1.6 1.1 -3.0 -0.5 0.9 -0.7 0.8 1.1
Trunk fat mass 0.2 0.9 2.7 1.2 0.0 1.6 1.1 -1.3 0.5 0.9 -0.6 0.2 0.9
Waist circumference 0.9 3.1 7.3 2.4 0.0 2.7 2.2 -0.7 0.8 2.0 -2.1 0.4 2.0
Number of incorrect matches in round 1.1 1.8 4.4 -1.8 0.0 -0.7 -1.5 -1.3 -1.0 -1.6 2.1 -0.6 -1.4
Past tobacco smoking 0.9 1.6 5.6 0.1 0.0 1.7 1.0 -0.1 2.4 0.9 -1.3 -2.0 0.7
Alcohol usually taken with meals 0.2 0.3 0.9 -0.5 0.0 -0.7 -0.6 -0.4 0.8 -0.9 0.5 -0.5 -0.4
Nervous feelings 1.2 2.2 4.0 -1.7 0.0 -1.0 -2.0 2.0 -1.1 -1.4 1.8 0.9 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.8 1.5 0.0 1.2 0.8 0.7 -0.1 1.1 -1.2 2.2 1.2
Hearing difficulty/problems with background noise 0.2 0.3 1.6 0.0 0.0 0.5 0.4 0.3 0.4 0.5 -0.3 -1.3 0.1
Hair/balding pattern: Pattern 2 0.4 0.5 1.3 -1.1 0.0 0.1 -0.8 -0.1 0.7 -0.8 0.6 -0.8 -1.1
Had menopause 0.6 0.7 2.1 0.3 0.0 1.4 0.9 -0.7 0.7 0.6 -1.1 -1.2 0.8
Had other major operations 1.1 1.4 3.0 1.7 0.0 0.1 1.6 -1.1 -0.9 1.7 -1.1 0.4 1.5
Forced vital capacity (FVC) 0.2 0.8 1.9 -0.9 0.0 -1.4 -0.5 -0.9 0.6 -0.5 1.1 -1.2 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 2.0 4.5 9.1 2.7 0.0 1.1 2.8 -2.5 0.6 3.0 -2.1 0.6 2.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 3.0 -0.0 0.0 -0.7 -0.2 1.7 -0.5 0.4 -0.0 0.8 0.0
Qualifications: None of the above 0.8 1.7 6.0 1.1 0.0 2.4 1.2 -0.2 -0.8 1.4 -1.7 0.9 1.4
Financial difficulties in last 2 years 0.8 1.1 6.6 1.1 0.0 -0.3 0.1 -0.7 -1.4 0.4 0.3 2.6 0.4
Mouth/teeth dental problems 1.1 1.6 2.8 -1.7 0.0 -1.5 -1.5 -0.9 -1.4 -1.3 1.6 -0.3 -1.3
Heart attack 0.8 1.0 2.8 -1.2 0.0 0.4 -1.2 -0.4 0.4 -1.5 1.1 -0.7 -1.7
Allergy 0.1 0.3 0.8 0.4 0.0 0.9 0.5 0.8 0.3 0.6 -0.4 -0.1 0.7
Pain all over the body in last month 0.7 0.7 3.2 0.7 0.0 1.0 0.6 -1.1 -0.3 0.7 -1.8 0.5 0.5
Diabetes (self-reported) 1.0 1.5 3.5 1.5 0.0 1.9 1.2 -1.9 -0.1 0.9 -1.1 0.8 1.3
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.8 -1.0 0.0 -0.9 -0.9 -0.0 1.7 -1.0 0.3 -1.1 -1.1
Medication: Ramipril 1.1 1.4 6.3 0.9 0.0 2.5 1.2 -1.1 1.4 0.8 -0.6 -0.7 1.0
Medication: Simvastatin 1.3 1.9 6.7 1.9 0.0 1.7 1.0 -0.5 -0.3 1.3 -1.3 2.6 1.1
Fluid intelligence score 0.5 1.1 5.8 -0.8 0.0 -2.4 -1.1 1.0 0.2 -1.2 0.1 0.3 -1.1
Illnesses of siblings 0.3 0.5 0.9 -0.2 0.0 -0.9 -0.7 -0.7 -0.9 -0.5 0.9 0.9 -0.5
Neuroticism score 0.6 1.2 5.4 0.1 0.0 -0.8 -0.4 2.2 -1.1 0.3 -0.0 2.3 0.1
Weight 0.3 1.6 5.0 1.4 0.0 1.9 1.4 -2.2 0.5 1.1 -0.8 0.1 1.2
Impedance of arm (right) 0.2 0.9 2.1 -1.1 0.0 -0.9 -1.0 -0.6 -0.7 -1.2 1.4 -0.8 -1.1
Arm fat percentage (right) 0.2 0.8 2.2 1.3 0.0 1.5 1.0 -0.0 0.1 0.7 -1.0 0.8 0.9
Trunk fat-free mass 0.2 1.1 7.9 0.6 0.0 1.2 0.7 -2.8 -0.0 0.7 -0.1 -0.0 0.7
Hip circumference 0.2 0.7 2.3 0.7 0.0 1.5 0.7 -1.2 -0.2 0.7 -1.0 0.5 0.5
Time employed in main current job 0.6 0.7 4.4 -0.8 0.0 -0.2 -0.7 2.1 -0.1 -0.5 0.2 0.4 -0.7
Alcohol intake versus 10 years previously 0.2 0.3 1.9 0.2 0.0 0.2 -0.4 0.2 -0.8 -0.2 0.1 1.4 0.1
Father’s age at death 0.5 0.6 3.5 0.8 0.0 -0.1 0.7 -1.9 -0.2 0.8 -0.4 0.3 0.7
Worrier / anxious feelings 0.6 1.1 6.0 0.1 0.0 -0.1 -0.5 0.8 -1.7 0.1 1.1 2.5 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.4 -0.1 0.0 0.2 -0.1 -0.5 -0.0 0.1 0.7 0.3 -0.2
Falls in the last year 0.7 1.0 2.2 -1.1 0.0 -0.7 -1.2 1.5 -0.7 -1.2 0.4 -0.1 -1.4
Hair/balding pattern: Pattern 3 1.2 1.8 3.6 1.9 0.0 1.6 1.4 1.4 -0.1 1.1 -1.8 0.8 1.6
Number of live births 2.1 2.9 7.2 1.6 0.0 1.6 2.3 -0.7 0.9 2.7 -2.5 -0.8 1.9
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.5 -1.0 0.0 -1.3 -0.6 -0.5 1.6 -0.8 0.8 -1.5 -0.8
Pulse rate 1.0 1.8 3.1 1.5 0.0 1.7 1.5 -1.5 1.5 1.6 -1.0 -0.3 1.3
Happiness 0.9 1.0 2.9 -1.4 0.0 -0.9 -1.4 1.7 -0.4 -1.1 0.2 0.1 -1.1
Noisy workplace 0.2 0.2 1.0 0.0 0.0 -0.0 -0.2 0.6 -0.5 -0.0 -0.5 1.0 -0.2
Qualifications: A levels/AS levels or equivalent 0.5 1.1 3.6 -0.7 0.0 -1.1 -0.1 1.5 1.5 -0.7 -0.7 -1.9 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 2.4 -0.4 0.0 -1.6 -0.4 -0.4 0.9 -0.8 0.1 -1.0 -0.3
Mouth/teeth dental problems: Dentures 1.2 2.0 5.5 1.7 0.0 1.7 1.3 0.7 -0.7 1.4 -2.4 1.4 1.5
Asthma 0.5 1.0 2.5 -0.8 0.0 -0.5 -0.4 -1.2 1.3 -1.0 1.3 -1.6 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 3.4 -1.5 0.0 -1.8 -1.5 1.2 0.4 -1.2 1.7 -0.5 -1.6
Medication: Cholesterol lowering 0.3 0.5 1.3 1.1 0.0 0.9 0.6 0.4 0.7 0.5 -0.4 1.0 0.7
Depression (self-reported) 0.3 0.3 1.7 -0.3 0.0 -0.4 -0.5 1.3 -0.4 -0.3 -0.7 0.4 -0.4
Medication: Lansoprazole 0.4 0.5 1.1 -0.8 0.0 -0.6 -0.9 0.3 0.2 -1.0 0.9 -0.1 -1.0
Prospective memory result 1.7 2.1 7.5 0.9 0.0 2.7 1.5 -1.9 -0.4 2.0 -0.9 -0.8 1.4
Lung cancer (father) 0.2 0.2 0.9 -0.2 0.0 0.3 0.1 -0.6 0.4 0.1 0.4 -0.9 -0.0
Illnesses of mother 0.3 0.4 1.1 -0.6 0.0 -0.6 -0.4 -1.0 0.9 -0.8 0.2 -0.7 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 4.2 -1.2 0.0 -2.1 -1.1 -0.1 1.2 -1.1 1.0 -0.9 -1.1
Pulse wave Arterial Stiffness index 0.8 0.9 3.4 0.8 0.0 1.1 1.0 0.1 0.2 1.3 -1.9 -0.4 0.8
Impedance of arm (left) 0.1 0.6 1.0 -0.9 0.0 -0.6 -0.7 -0.7 -0.2 -0.9 1.0 -1.0 -0.9
Arm fat mass (right) 0.1 0.6 1.7 1.1 0.0 1.3 0.8 -0.8 -0.1 0.6 -0.6 0.8 0.7
Trunk predicted mass 0.2 1.1 7.8 0.6 0.0 1.2 0.7 -2.8 0.1 0.8 -0.1 -0.0 0.7
Standing height 0.4 3.6 29.1 -0.3 0.0 1.1 0.3 -5.4 0.2 -0.0 1.6 -1.8 -0.1
Length of working week for main job 1.9 2.1 4.5 1.6 0.0 0.2 1.4 2.0 0.9 1.8 -2.1 1.2 1.4
Exposure to tobacco smoke at home 1.1 1.2 3.0 1.4 0.0 0.6 1.0 -1.7 -0.2 1.3 -1.2 1.4 1.0
Breastfed as a baby 1.3 1.6 3.8 1.9 0.0 0.4 1.4 0.1 -1.3 1.4 -0.7 1.9 1.6
Tense / ‘highly strung’ 0.3 0.4 1.0 0.8 0.0 -0.0 0.6 0.7 0.0 1.0 -0.5 0.7 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.6 -0.9 0.0 -0.3 -1.1 0.7 -0.1 -1.1 1.3 -0.1 -1.0
Hair/balding pattern: Pattern 4 0.1 0.2 1.5 -0.3 0.0 -0.1 0.2 -0.5 1.2 0.2 0.3 -0.6 0.2
Birth weight of first child 0.2 0.3 1.6 -0.1 0.0 0.1 -0.3 0.2 1.2 -0.9 -0.1 -0.6 -0.4
Peak expiratory flow (PEF) 0.5 1.2 2.7 -1.2 0.0 -0.8 -0.9 0.9 1.6 -1.3 1.1 -1.4 -1.1
Pulse wave reflection index 0.8 1.0 3.1 -1.3 0.0 -1.3 -1.1 1.8 0.2 -0.9 0.2 -0.7 -1.1
Ever highly irritable/argumentative for 2 days 2.1 2.5 4.9 -2.0 0.0 -2.0 -2.2 1.2 -0.7 -1.8 1.6 0.3 -2.1
Loud music exposure frequency 2.6 2.8 5.2 2.1 0.0 2.3 2.3 -0.5 0.1 2.0 -2.2 0.0 2.2
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 7.1 0.1 0.0 -0.4 0.9 1.0 2.7 0.2 -0.6 -2.4 0.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 4.5 0.6 0.0 0.4 0.3 0.7 2.1 -0.1 0.5 -0.3 0.4
Blood clot in the leg (DVT) 0.5 0.7 3.0 0.1 0.0 -0.4 -0.4 -0.8 -1.7 -0.1 0.4 1.6 -0.0
Medication: Paracetamol 0.3 0.5 2.4 0.1 0.0 -0.5 -0.5 -0.0 -0.9 -0.3 0.9 1.6 -0.4
Headache pain in last month 0.3 0.6 3.5 -0.3 0.0 -0.6 -0.5 1.9 0.6 -0.7 0.5 -0.0 -0.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.3 -0.1 0.0 -0.0 0.4 -1.0 0.1 -0.0 -0.6 -1.1 0.3
Glaucoma (self-reported) 0.1 0.1 0.2 0.4 0.0 0.3 0.4 -0.1 0.0 0.4 -0.2 0.2 0.3
Gout (self-reported) 2.1 2.9 6.8 2.2 0.0 1.7 2.2 -1.4 0.5 2.1 -2.6 0.1 1.7
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 3.2 0.3 0.0 -0.8 -0.1 0.6 -1.8 0.0 -0.7 1.0 0.0
Medication: Amlodipine 0.5 0.6 1.3 0.8 0.0 1.0 0.7 -1.1 1.1 0.3 -1.0 -0.1 0.7
Medication: Ventolin 100micrograms inhaler 1.3 1.7 4.4 -1.6 0.0 -1.1 -1.4 -0.9 0.8 -1.5 2.1 -0.7 -1.5
Birth weight 0.7 1.6 4.5 -1.5 0.0 -1.3 -1.7 -0.3 -0.5 -2.1 1.6 -0.4 -1.3
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.1 -0.5 0.0 1.0 -0.2 -0.0 0.2 -0.5 -1.1 -0.3 -0.4
High blood pressure (siblings) 0.6 0.9 4.6 -0.2 0.0 0.7 0.4 2.1 0.7 0.4 -1.4 -1.2 -0.0
Forced vital capacity (FVC), Best measure 0.3 1.0 4.5 -1.1 0.0 -2.1 -0.9 -0.3 0.2 -0.8 1.4 -0.7 -0.9
Body fat percentage 0.2 0.8 2.2 1.3 0.0 1.5 1.1 -0.5 0.7 0.9 -0.9 0.2 0.9
Leg fat percentage (right) 0.1 0.4 0.9 0.9 0.0 0.9 0.6 0.1 0.5 0.6 -0.6 0.5 0.5
Arm fat-free mass (right) 0.3 1.5 6.0 1.2 0.0 1.5 1.3 -2.5 0.6 1.3 -0.7 0.0 1.1
Exposure to tobacco smoke outside home 0.9 1.2 4.3 -1.2 0.0 -2.1 -1.0 0.2 -0.1 -0.8 1.3 -0.9 -1.3
Comparative body size at age 10 0.2 0.6 1.8 -0.5 0.0 0.2 -0.7 1.3 -1.0 -1.0 -0.9 1.0 -0.3
Number of full brothers 0.2 0.3 1.1 0.5 0.0 -0.3 0.8 -0.2 0.5 1.0 -0.5 -0.1 0.7
Worry too long after embarrassment 1.4 2.4 10.3 0.9 0.0 0.7 0.4 3.2 -1.8 0.8 -1.3 2.4 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 2.5 -0.6 0.0 -0.8 -0.7 1.1 0.7 -0.3 1.6 -0.3 -1.1
Wheeze or whistling in the chest in last year 0.5 0.8 2.0 -0.9 0.0 -0.7 -0.7 -1.0 1.1 -0.7 1.4 -0.8 -1.1
Number of children fathered 0.7 0.8 2.4 1.1 0.0 0.9 1.2 0.1 1.0 1.5 -0.4 -0.0 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 3.4 -0.4 0.0 -0.1 0.0 0.3 1.8 -0.2 0.0 -1.4 -0.4
Age at first live birth 0.5 0.9 4.7 0.4 0.0 0.1 1.0 -0.2 2.2 0.6 -0.4 -1.6 0.4
Pulse wave peak to peak time 0.9 1.0 3.9 -0.9 0.0 -1.2 -1.0 -0.3 -0.2 -1.4 2.0 0.2 -0.9
Health satisfaction 2.4 3.1 8.9 2.3 0.0 3.0 2.1 0.5 0.6 2.1 -1.6 0.7 2.1
Shortness of breath walking on level ground 0.5 0.6 1.6 0.8 0.0 0.9 0.6 -1.0 -0.1 0.7 -0.5 1.2 1.0
Qualifications: College or University degree 1.2 3.9 9.6 -2.3 0.0 -3.1 -2.3 2.1 0.2 -2.4 1.8 -1.0 -2.2
Eye problems/disorders: None of the above 0.8 0.9 1.7 -1.2 0.0 -1.2 -1.3 1.3 0.6 -0.9 0.3 0.3 -1.2
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.6 1.6 0.0 1.2 1.5 0.6 0.9 1.3 -1.2 0.1 1.6
Emphysema/chronic bronchitis 0.4 0.5 1.3 0.1 0.0 0.8 1.0 0.2 0.6 1.1 -0.7 -1.1 0.3
Medication for pain relief, constipation, heartburn 0.1 0.1 0.8 -0.3 0.0 -0.2 -0.2 -0.4 -0.5 -0.0 -0.9 0.0 0.1
Neck or shoulder pain in last month 0.6 0.9 3.4 0.2 0.0 -1.0 -0.5 -0.8 -1.0 0.1 1.8 1.6 -0.1
Medication: Blood pressure 0.1 0.2 0.9 0.4 0.0 0.9 0.2 0.8 -0.1 0.4 0.5 0.4 0.1
Angina (self-reported) 0.4 0.5 2.4 0.8 0.0 0.7 0.2 0.1 -0.8 0.6 -0.4 1.5 0.4
Migraine (self-reported) 1.7 2.1 5.7 1.4 0.0 1.9 1.7 1.7 0.6 1.1 -2.4 -0.1 1.4
Medication: Ibuprofen 1.9 2.3 5.8 -1.8 0.0 -1.8 -1.8 1.1 -0.1 -1.6 2.4 -0.5 -1.8
Medication: Allopurinol 0.8 1.0 3.2 0.9 0.0 0.4 1.0 -1.5 0.7 1.3 -1.8 -0.4 0.6
Medication: Omeprazole 0.7 0.9 1.5 1.2 0.0 1.0 1.2 1.2 0.9 1.1 -1.0 -0.3 0.6
Medication: Seretide 50 evohaler 1.0 1.2 2.3 -1.4 0.0 -0.5 -1.3 1.0 0.1 -1.5 1.5 -0.0 -1.5
Mean time to correctly identify matches 0.2 0.3 1.3 -0.7 0.0 0.3 -0.2 -0.3 -0.9 -0.1 0.6 -1.1 -0.3
Heart disease (mother) 0.2 0.3 1.3 0.3 0.0 1.1 0.5 0.9 -0.1 0.6 0.2 -0.3 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.7 0.8 0.0 0.3 0.8 -0.1 0.1 0.6 -0.6 0.1 0.6
Whole body fat mass 0.2 0.8 2.2 1.1 0.0 1.5 0.9 -1.3 0.5 0.8 -0.7 0.3 0.7
Leg fat mass (right) 0.2 0.9 1.7 1.3 0.0 1.3 1.0 -1.3 0.1 0.9 -0.8 0.9 0.9
Arm predicted mass (right) 0.3 1.4 5.4 1.1 0.0 1.4 1.2 -2.3 0.6 1.3 -0.8 -0.0 1.1
Pulse rate, automated reading 0.8 2.6 4.7 2.0 0.0 1.6 1.9 -1.5 2.2 1.8 -1.7 -0.0 1.8
Alcohol intake frequency. 1.0 2.3 11.8 1.2 0.0 3.4 1.4 -1.2 1.2 0.7 -1.6 -0.7 1.4
Comparative height size at age 10 0.3 1.8 14.5 -0.3 0.0 0.9 0.2 -3.8 0.1 -0.2 1.1 -1.0 0.1
Number of full sisters 0.9 1.1 2.3 -0.9 0.0 -1.4 -1.4 -1.0 -0.5 -1.5 0.7 0.9 -1.2
Suffer from ‘nerves’ 0.2 0.3 2.2 -0.2 0.0 -0.1 -0.2 1.5 0.3 -0.1 -0.3 0.2 -0.2
Overall health rating 0.6 1.3 4.9 1.4 0.0 2.2 0.9 0.1 -0.2 1.0 -0.4 1.7 1.1
Chest pain or discomfort 0.2 0.3 1.3 0.6 0.0 1.2 0.3 0.0 1.1 0.1 0.5 -0.1 0.1
Had major operations 0.9 1.0 2.1 0.9 0.0 1.4 1.3 -1.3 -0.8 1.4 -0.1 0.1 1.0
Age at last live birth 0.7 1.0 4.1 0.7 0.0 0.0 1.0 0.4 2.0 0.9 -1.1 -1.3 0.4
Family relationship satisfaction 0.1 0.1 0.9 -0.2 0.0 -0.1 0.0 0.4 0.1 0.1 -0.9 -0.2 -0.0
Leg pain on walking 0.6 0.7 2.5 0.3 0.0 1.5 0.5 0.8 1.6 0.7 0.1 -0.9 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.7 0.9 0.0 1.3 0.7 -0.5 0.6 0.3 0.6 -0.0 0.5
Commuting to job workplace: Car/motor vehicle 1.1 1.2 3.7 -0.3 0.0 -1.9 -0.9 1.8 -1.3 -0.4 -0.1 1.4 -0.7
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 2.4 -1.3 0.0 -0.5 -0.5 1.5 0.6 -0.6 -0.2 -1.4 -0.8
Medication: Aspirin 0.6 0.8 1.5 1.2 0.0 1.2 1.2 -0.2 1.1 0.8 -0.8 -0.5 0.9
Supplements: Vitamin C 0.4 0.5 1.2 0.6 0.0 0.7 0.8 0.8 0.2 0.8 -1.1 -0.3 0.6
Knee pain experienced in last month 2.2 3.4 8.1 2.4 0.0 1.4 1.8 -0.6 -1.6 2.4 -1.3 2.9 2.1
Hypertension (Self-reported) 0.7 2.1 4.3 1.8 0.0 2.1 1.9 0.4 0.2 2.0 -1.2 0.4 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 1.4 0.3 0.0 -0.5 0.1 -1.2 0.3 0.1 -0.4 0.5 0.1
Illnesses of father: Heart disease 1.0 1.3 5.9 -1.0 0.0 0.1 -0.5 2.4 2.0 -0.6 -0.0 -1.1 -0.6
Illnesses of siblings: Diabetes 0.2 0.2 1.1 -0.0 0.0 -0.3 0.3 -0.5 0.5 -0.0 -0.3 -1.0 0.2
Smoking status: Previous 0.6 0.8 3.4 0.5 0.0 -1.3 -0.2 -0.2 -1.8 -0.3 0.4 1.6 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.5 -0.6 0.0 -1.4 -0.8 -1.5 0.2 -0.7 1.9 -0.0 -0.8
Whole body fat-free mass 0.3 1.6 8.9 1.0 0.0 1.5 1.0 -3.0 -0.1 1.0 -0.5 0.3 1.0
Leg fat-free mass (right) 0.4 2.0 8.4 1.4 0.0 1.9 1.3 -2.9 -0.5 1.1 -1.0 0.6 1.3
Arm fat percentage (left) 0.2 0.8 2.4 1.3 0.0 1.6 1.0 -0.1 0.3 0.7 -0.9 0.7 0.9
Average weekly red wine intake 1.8 2.7 5.1 -2.1 0.0 -2.0 -2.0 1.3 0.5 -2.3 1.7 -1.1 -2.0
Handedness (chirality/laterality): Left-handed 1.4 1.7 3.9 1.6 0.0 0.6 1.9 -1.9 0.3 1.5 -0.5 -0.1 2.0
Mood swings 0.7 1.2 2.6 -1.2 0.0 -1.4 -1.2 1.3 0.7 -0.9 1.6 0.3 -1.2
Loneliness, isolation 1.7 2.3 5.6 2.0 0.0 1.2 1.4 -1.5 -1.3 1.4 -1.3 2.4 1.7
Long-standing illness, disability or infirmity 1.2 1.8 2.9 1.6 0.0 1.6 1.4 0.1 -1.2 1.7 -1.5 1.5 1.4
Ever had bowel cancer screening 0.5 0.6 3.0 0.3 0.0 1.7 0.6 -1.1 -0.3 0.6 0.1 -0.8 0.7
Diabetes diagnosed by doctor 1.3 2.1 4.7 1.7 0.0 2.2 1.6 -1.6 -0.1 1.3 -1.7 0.7 1.8
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.1 3.4 1.4 0.0 1.7 1.7 -0.2 1.7 1.8 -1.8 -1.2 1.4
Friendships satisfaction 0.3 0.3 1.8 -0.4 0.0 0.2 -0.2 1.3 -0.1 -0.4 -1.0 -0.2 -0.0
Qualifications: nursing, teaching 0.4 0.7 4.5 0.1 0.0 -1.1 0.1 2.1 0.4 -0.2 -0.8 -0.1 0.2
Commuting to job workplace: Walk 0.3 0.3 1.2 0.0 0.0 0.5 0.5 -0.7 -0.4 0.3 -0.3 -1.1 0.8
Eye problems/disorders: Cataract 1.1 1.3 3.6 1.1 0.0 1.9 1.6 0.3 0.5 1.2 -1.6 -0.8 1.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 1.0 0.4 0.0 -0.4 0.3 -0.3 0.3 1.0 0.1 0.7 0.1
Medication for cholesterol 0.7 1.1 3.7 -1.2 0.0 -1.9 -1.1 0.7 -0.2 -1.2 0.3 -1.0 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.4 -0.5 0.0 0.4 -0.4 -0.1 -0.4 -0.2 0.4 -0.0 -0.6
Back pain experienced in last month 0.8 1.1 4.2 1.1 0.0 0.3 0.7 -0.7 -1.4 1.2 -0.2 2.0 1.2
Mineral and other dietary supplements 0.1 0.1 0.2 0.5 0.0 0.3 0.4 0.1 0.4 0.4 0.2 0.0 0.4
Breast cancer (self-reported) 1.3 1.5 2.6 1.6 0.0 1.6 1.4 -1.1 0.9 1.6 -1.2 0.2 1.4
Asthma (self-reported) 0.6 1.2 2.5 -0.9 0.0 -0.6 -0.6 -1.3 1.3 -1.2 1.6 -1.5 -0.9
Osteoporosis (self-reported) 0.7 0.9 3.8 0.2 0.0 1.9 0.7 -1.5 0.3 0.1 -0.6 -1.4 0.3
Osteoarthritis (self-reported) 0.2 0.2 0.7 -0.2 0.0 -0.9 -0.4 -0.2 0.0 -0.3 0.4 0.7 -0.6
Medication: Aspirin 1.6 2.1 3.8 1.8 0.0 1.8 2.0 -0.3 1.8 1.6 -1.3 -0.7 1.5
Medication: Gliclazide 0.8 0.9 4.2 0.7 0.0 0.9 0.7 -2.0 -0.1 0.9 -0.6 0.7 0.8
Illnesses of father: None of the above (group 1) 2.3 2.8 4.9 2.1 0.0 1.4 2.0 -2.2 -0.5 2.1 -1.9 0.5 2.0
Smoking status: Current 0.2 0.3 1.5 -0.3 0.0 0.0 -0.6 -0.5 -0.1 -0.4 0.4 1.2 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.2 -0.0 0.0 -1.0 0.6 0.2 1.5 0.5 -0.7 -1.4 0.3
Whole body water mass 0.2 1.4 8.0 0.9 0.0 1.4 1.0 -2.8 -0.0 0.9 -0.5 0.2 0.9
Leg predicted mass (right) 0.4 2.2 8.6 1.5 0.0 1.9 1.4 -2.9 -0.6 1.2 -1.1 0.7 1.4
Arm fat mass (left) 0.2 0.8 2.1 1.2 0.0 1.5 1.0 -0.7 0.4 0.8 -1.0 0.6 0.9
Number of self-reported non-cancer illnesses 1.3 2.2 4.5 2.0 0.0 1.9 1.9 -0.9 0.7 1.8 -2.1 0.5 1.5
Average weekly champagne plus white wine intake 0.2 0.3 1.2 0.0 0.0 -0.6 -0.2 0.6 -1.1 -0.3 0.7 0.3 -0.1
Miserableness 0.7 1.3 2.0 -1.2 0.0 -1.4 -1.4 1.2 -0.2 -0.9 1.3 1.3 -1.2
Guilty feelings 0.9 1.4 4.3 -0.4 0.0 -2.1 -1.2 0.9 -1.4 -0.8 0.6 2.0 -0.5
Wears glasses or contact lenses 0.8 0.9 3.3 -0.4 0.0 -0.6 -0.9 1.1 -1.8 -0.3 0.7 1.6 -0.6
Ever taken oral contraceptive pill 0.2 0.2 1.0 -0.2 0.0 -0.8 -0.2 1.0 -0.0 0.1 -0.5 0.0 -0.5
Hearing aid user 3.5 3.9 9.3 2.2 0.0 2.0 2.7 0.1 0.8 3.1 -2.4 0.1 2.7
Mother’s age at death 2.5 3.1 5.6 -2.4 0.0 -2.2 -2.1 0.1 0.1 -2.2 1.9 -1.5 -2.3
Financial situation satisfaction 0.4 0.5 1.4 0.8 0.0 0.5 0.5 1.2 0.3 0.7 -1.0 0.9 0.6
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.9 0.2 0.0 0.6 -0.2 0.7 -1.4 -0.6 -0.1 0.6 0.1
Commuting to job workplace: Public transport 0.4 0.4 1.9 -0.2 0.0 0.3 0.4 -0.9 1.0 0.4 0.3 -1.4 0.2
Eye problems/disorders: Glaucoma 0.1 0.2 0.6 -0.5 0.0 -0.2 -0.5 -0.1 0.2 -0.6 0.8 -0.2 -0.5
Medication: Blood pressure 0.4 0.7 1.5 0.8 0.0 1.2 1.0 -0.3 0.8 0.9 -1.1 -0.2 1.0
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.5 0.9 0.0 1.2 0.9 1.2 0.4 1.1 -0.2 0.7 0.5
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.5 -0.7 0.0 -0.3 -0.6 0.5 -0.5 -0.5 0.1 -0.2 -0.6
High cholesterol (Self-reported) 1.1 2.0 5.1 2.3 0.0 1.2 1.4 0.0 0.2 1.6 -1.3 2.2 1.6
Medication: Bendroflumethiazide 0.6 1.0 2.2 0.7 0.0 1.3 1.1 1.5 -0.0 1.2 -0.9 -0.0 1.2
Medication: Paracetamol 0.2 0.3 2.0 0.6 0.0 -0.1 0.0 -0.2 -0.8 0.1 0.3 1.4 0.3
Medication: Lisinopril 0.8 1.1 2.4 1.4 0.0 0.8 1.3 -0.2 1.0 1.5 -1.1 0.4 1.2
Medication: Atorvastatin 0.4 0.5 1.1 -0.8 0.0 -1.0 -0.6 -0.9 0.5 -0.6 0.8 -0.8 -0.6
Illnesses of father: High blood pressure 1.7 2.1 8.2 -1.2 0.0 -0.9 -1.6 1.6 0.3 -1.6 2.9 0.3 -1.5
Alcohol drinker status: Never 0.3 0.3 0.8 -0.8 0.0 0.7 -0.6 -0.2 0.9 -0.4 0.5 -0.7 -0.5
Ever smoked 1.2 2.2 8.3 -0.2 0.0 -1.3 -1.2 -0.2 -2.9 -0.9 1.4 2.6 -0.8
Basal metabolic rate 0.3 1.4 7.6 1.1 0.0 1.4 1.1 -2.8 0.0 1.0 -0.6 0.3 1.0
Leg fat percentage (left) 0.2 0.6 1.5 1.0 0.0 1.2 0.8 0.2 0.6 0.9 -0.9 0.4 0.7
Arm fat-free mass (left) 0.3 1.6 5.3 1.3 0.0 1.5 1.3 -2.3 0.5 1.3 -0.9 0.1 1.3
Number of operations (self-reported) 1.5 2.2 4.1 1.5 0.0 1.8 2.0 -2.0 0.1 1.9 -1.3 -0.6 1.8
Average weekly beer plus cider intake 0.6 0.9 4.6 -0.8 0.0 -0.9 -1.0 -0.6 0.2 -0.6 2.1 0.1 -1.0
Irritability 1.5 2.5 6.7 -1.3 0.0 -2.6 -1.8 2.5 -0.5 -1.3 1.0 1.5 -1.4
Risk taking 0.2 0.3 2.0 0.3 0.0 0.3 0.4 -1.4 0.1 0.1 -0.0 -0.6 0.3
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 0.1 0.0 0.0 -0.0 -0.4 -0.6 0.1 0.6 0.5 -0.2
Fractured/broken bones in last 5 years 0.6 0.8 1.5 -1.2 0.0 -0.0 -1.1 0.4 -1.1 -1.1 1.0 -0.1 -1.2
Age started oral contraceptive pill 0.3 0.4 1.0 0.4 0.0 0.9 0.6 -0.8 -0.2 0.3 -0.8 -0.2 1.0
Diastolic blood pressure, automated reading 0.5 1.5 4.7 1.6 0.0 0.7 1.8 -0.4 0.3 2.2 -1.1 -0.1 1.7
Ever depressed for a whole week 0.3 0.3 0.9 0.6 0.0 0.2 0.3 0.4 -1.0 0.5 0.5 0.9 0.5
Unable to work because of sickness or disability 0.4 0.5 1.0 0.8 0.0 0.8 0.9 0.3 0.9 0.6 -1.0 -0.4 0.6
Commuting to job workplace: Cycle 0.6 0.7 3.0 -0.9 0.0 0.3 -0.4 -0.3 1.4 -0.8 0.6 -1.7 -0.5
Myopia 0.9 1.3 2.5 -1.3 0.0 -1.5 -1.4 1.0 -0.1 -1.3 1.1 -0.7 -1.6
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.9 -1.3 0.0 -1.7 -1.1 -0.2 0.7 -1.3 0.8 -1.1 -1.2
Cholesterol lowering medication 1.6 2.3 4.8 2.2 0.0 1.5 1.5 -0.9 0.3 1.6 -2.1 1.8 1.6
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 4.2 2.0 0.0 1.7 2.0 1.3 1.4 1.6 -1.9 0.0 1.7
Pain experienced in last month 1.5 2.5 9.8 -1.3 0.0 -0.5 -0.5 0.4 3.0 -1.4 -0.3 -3.1 -1.1
Supplements: Calcium 0.2 0.2 0.7 -0.0 0.0 0.4 0.3 -0.7 0.3 0.4 -0.1 -0.9 -0.0
Basal cell carcinoma (self-reported) 0.3 0.4 1.8 -0.5 0.0 0.2 -0.4 0.2 1.4 -0.7 0.4 -0.8 -0.4
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.1 -1.0 0.0 0.4 -1.0 -0.5 0.4 -1.3 1.0 -0.5 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.7 0.2 0.0 -0.2 -0.3 -0.9 -1.3 -0.1 0.5 1.3 -0.1
Heart disease (siblings) 0.4 0.5 1.2 0.6 0.0 1.1 0.7 -1.1 -0.2 0.8 -0.4 0.3 0.9
Alcohol drinker status: Previous 2.3 2.7 6.9 1.3 0.0 2.4 1.9 -0.7 1.8 0.8 -2.6 -1.5 1.5
Pack years of smoking 0.7 1.0 2.9 0.8 0.0 1.3 0.7 1.7 0.6 0.8 -1.6 0.5 0.8
Impedance of whole body 0.3 1.6 3.2 -1.5 0.0 -1.3 -1.1 -0.3 0.9 -1.1 1.7 -1.8 -1.5
Leg fat mass (left) 0.3 1.0 2.2 1.3 0.0 1.5 1.1 -1.3 0.0 1.0 -0.9 0.8 1.0
Arm predicted mass (left) 0.2 1.1 5.3 0.8 0.0 1.2 0.9 -2.3 0.6 1.0 -0.5 -0.1 0.8