TWAS hub - SLPI

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.2560	0.0550	1.7e-12	0.186	NA	0.242	NA	0.232	1.6e-12	NA	3.2e-16	NA	1.5e-15
2	GTEx	Heart Atrial Appendage	0.6600	0.0850	1.3e-05	0.002	NA	0.009	NA	-0.001	2.6e-01	NA	1.2e-01	NA	3.6e-01
3	GTEx	Skin Not Sun Exposed Suprapubic	0.3310	0.0840	7.1e-07	0.092	NA	0.094	NA	0.086	9.2e-06	NA	8.2e-06	NA	1.9e-05
4	GTEx	Skin Sun Exposed Lower leg	0.2120	0.0510	3.1e-10	0.136	NA	0.123	NA	0.136	2.3e-11	NA	2.3e-10	NA	2.2e-11
5	METSIM	Adipose	0.0454	0.0213	4.1e-03	0.014	0.013	0.015	0.017	0.017	3.3e-03	3.4e-03	2.2e-03	0.0012	1.0e-03
6	NTR	Blood	0.0195	0.0092	5.8e-03	0.004	0.001	0.000	0.004	0.003	1.4e-02	1.8e-01	2.1e-01	0.0110	4.1e-02
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0341	0.0181	1.7e-04	0.046	0.038	0.036	NA	0.044	6.3e-06	4.1e-05	6.3e-05	NA	1.1e-05
8	TCGA	Brain Lower Grade Glioma	0.0646	0.0410	1.0e-03	0.009	0.026	0.026	NA	0.017	3.0e-02	4.8e-04	5.7e-04	NA	4.2e-03
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0610	0.0350	1.8e-03	0.001	0.018	0.033	NA	0.023	2.5e-01	2.0e-02	2.7e-03	NA	1.1e-02
10	TCGA	Prostate Adenocarcinoma	0.0321	0.0167	1.4e-04	0.037	0.034	0.022	NA	0.039	8.6e-05	1.6e-04	1.9e-03	NA	6.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	6.3	10.0	16.3	-3.9	-4.0	-3.5	0.5	2.6	-4.0	2.9	-3.2	-3.8
Schizophrenia vs Biploar Disorder	5.5	7.3	14.3	3.4	3.2	3.5	0.2	-0.6	3.8	-3.3	1.0	3.4
Bipolar Disorder (2011)	4.3	4.2	8.6	-2.8	-2.5	-2.1	0.3	1.7	-2.0	2.0	-1.9	-2.9
Hearing aid user	3.5	3.9	9.3	2.2	2.0	2.7	0.1	0.8	3.1	-2.4	0.1	2.7
Alzheimer’s Disease (in father)	3.4	3.7	6.6	-2.6	-1.0	-2.4	2.6	1.0	-2.5	1.9	-1.0	-2.5
Average weekly spirits intake	3.1	3.9	7.2	-2.7	-2.0	-2.3	2.6	1.6	-2.2	1.1	-1.2	-2.4
Loud music exposure frequency	2.6	2.8	5.2	2.1	2.3	2.3	-0.5	0.1	2.0	-2.2	0.0	2.2
Mother’s age at death	2.5	3.1	5.6	-2.4	-2.2	-2.1	0.1	0.1	-2.2	1.9	-1.5	-2.3
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	5.0	2.2	1.8	1.6	1.9	-1.1	2.1	-1.9	2.2	1.8
Health satisfaction	2.4	3.1	8.9	2.3	3.0	2.1	0.5	0.6	2.1	-1.6	0.7	2.1
Alzheimer’s Disease (in mother)	2.3	2.7	6.8	2.0	1.3	1.8	2.2	1.1	1.4	-2.6	-0.3	1.7
Illnesses of father: None of the above (group 1)	2.3	2.8	4.9	2.1	1.4	2.0	-2.2	-0.5	2.1	-1.9	0.5	2.0
Alcohol drinker status: Previous	2.3	2.7	6.9	1.3	2.4	1.9	-0.7	1.8	0.8	-2.6	-1.5	1.5
Knee pain experienced in last month	2.2	3.4	8.1	2.4	1.4	1.8	-0.6	-1.6	2.4	-1.3	2.9	2.1
Number of live births	2.1	2.9	7.2	1.6	1.6	2.3	-0.7	0.9	2.7	-2.5	-0.8	1.9
Ever highly irritable/argumentative for 2 days	2.1	2.5	4.9	-2.0	-2.0	-2.2	1.2	-0.7	-1.8	1.6	0.3	-2.1
Gout (self-reported)	2.1	2.9	6.8	2.2	1.7	2.2	-1.4	0.5	2.1	-2.6	0.1	1.7
Townsend deprivation index at recruitment	2.0	2.8	13.5	0.5	0.4	-0.7	-1.0	-3.7	-0.2	0.7	3.4	0.3
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	9.1	2.7	1.1	2.8	-2.5	0.6	3.0	-2.1	0.6	2.9
Length of working week for main job	1.9	2.1	4.5	1.6	0.2	1.4	2.0	0.9	1.8	-2.1	1.2	1.4
Medication: Ibuprofen	1.9	2.3	5.8	-1.8	-1.8	-1.8	1.1	-0.1	-1.6	2.4	-0.5	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	3.4	1.4	1.7	1.7	-0.2	1.7	1.8	-1.8	-1.2	1.4
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	4.2	2.0	1.7	2.0	1.3	1.4	1.6	-1.9	0.0	1.7
Average weekly red wine intake	1.8	2.7	5.1	-2.1	-2.0	-2.0	1.3	0.5	-2.3	1.7	-1.1	-2.0
Prospective memory result	1.7	2.1	7.5	0.9	2.7	1.5	-1.9	-0.4	2.0	-0.9	-0.8	1.4
Migraine (self-reported)	1.7	2.1	5.7	1.4	1.9	1.7	1.7	0.6	1.1	-2.4	-0.1	1.4
Loneliness, isolation	1.7	2.3	5.6	2.0	1.2	1.4	-1.5	-1.3	1.4	-1.3	2.4	1.7
Illnesses of father: High blood pressure	1.7	2.1	8.2	-1.2	-0.9	-1.6	1.6	0.3	-1.6	2.9	0.3	-1.5
Bipolar Disorder or Schizophrenia	1.6	4.0	8.5	-2.1	-2.5	-1.8	0.4	2.9	-2.4	1.8	-2.2	-2.0
Medication: Aspirin	1.6	2.1	3.8	1.8	1.8	2.0	-0.3	1.8	1.6	-1.3	-0.7	1.5
Cholesterol lowering medication	1.6	2.3	4.8	2.2	1.5	1.5	-0.9	0.3	1.6	-2.1	1.8	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	5.4	1.7	1.7	1.2	-0.6	-0.6	1.4	-1.6	2.3	1.5
Number of operations (self-reported)	1.5	2.2	4.1	1.5	1.8	2.0	-2.0	0.1	1.9	-1.3	-0.6	1.8
Irritability	1.5	2.5	6.7	-1.3	-2.6	-1.8	2.5	-0.5	-1.3	1.0	1.5	-1.4
Pain experienced in last month	1.5	2.5	9.8	-1.3	-0.5	-0.5	0.4	3.0	-1.4	-0.3	-3.1	-1.1
Verbal and Numeric Reasoning (VNR)	1.4	3.4	10.8	-1.7	-3.3	-2.1	2.3	0.9	-2.1	0.7	0.0	-2.2
Body Mass Index (BMI) (2010)	1.4	1.9	3.8	1.7	1.0	1.5	0.8	-0.8	1.7	-1.9	1.2	1.9
Systolic blood pressure, automated reading	1.4	4.0	11.0	2.6	1.2	2.6	0.2	-0.4	3.3	-2.0	1.3	2.9
Average weekly fortified wine intake	1.4	1.7	6.7	0.2	1.7	1.0	0.1	2.6	0.3	-1.1	-2.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	9.7	2.0	0.6	2.2	-3.1	0.7	2.2	-1.3	-0.2	2.2
Multivitamins +/- minerals	1.4	1.8	3.7	-1.9	-1.3	-1.9	1.1	-0.9	-1.8	0.4	-0.0	-1.8
Worry too long after embarrassment	1.4	2.4	10.3	0.9	0.7	0.4	3.2	-1.8	0.8	-1.3	2.4	0.8
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.9	1.6	0.6	1.9	-1.9	0.3	1.5	-0.5	-0.1	2.0
Breast Cancer	1.3	3.1	7.7	-2.4	-1.1	-2.5	0.8	0.4	-2.8	1.6	-0.6	-2.5
Coronary Artery Disease (CAD)	1.3	1.6	3.9	1.4	2.0	1.7	-1.0	0.3	1.7	-0.9	-0.3	1.7
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	7.1	-0.4	0.8	0.4	0.3	2.7	0.2	-0.5	-2.6	-0.2
Medication: Atenolol	1.3	1.6	4.7	1.5	1.5	1.4	-2.2	-0.5	1.1	-1.2	0.9	1.3
Medication: Simvastatin	1.3	1.9	6.7	1.9	1.7	1.0	-0.5	-0.3	1.3	-1.3	2.6	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.4	-1.5	-1.8	-1.5	1.2	0.4	-1.2	1.7	-0.5	-1.6
Breastfed as a baby	1.3	1.6	3.8	1.9	0.4	1.4	0.1	-1.3	1.4	-0.7	1.9	1.6
Medication: Ventolin 100micrograms inhaler	1.3	1.7	4.4	-1.6	-1.1	-1.4	-0.9	0.8	-1.5	2.1	-0.7	-1.5
Diabetes diagnosed by doctor	1.3	2.1	4.7	1.7	2.2	1.6	-1.6	-0.1	1.3	-1.7	0.7	1.8
Breast cancer (self-reported)	1.3	1.5	2.6	1.6	1.6	1.4	-1.1	0.9	1.6	-1.2	0.2	1.4
Number of self-reported non-cancer illnesses	1.3	2.2	4.5	2.0	1.9	1.9	-0.9	0.7	1.8	-2.1	0.5	1.5
HbA1C	1.2	1.3	3.7	-1.2	-0.9	-1.9	1.0	-0.4	-1.7	0.6	0.6	-1.7
Type 2 Diabetes (T2D) (2012)	1.2	1.3	5.2	-0.6	-0.7	-0.8	-1.9	-0.9	-1.2	2.3	0.1	-0.8
Supplements: Glucosamine	1.2	1.5	4.3	-2.1	-1.4	-1.7	0.1	-0.4	-1.2	1.1	-0.7	-1.7
Nervous feelings	1.2	2.2	4.0	-1.7	-1.0	-2.0	2.0	-1.1	-1.4	1.8	0.9	-1.7
Hair/balding pattern: Pattern 3	1.2	1.8	3.6	1.9	1.6	1.4	1.4	-0.1	1.1	-1.8	0.8	1.6
Mouth/teeth dental problems: Dentures	1.2	2.0	5.5	1.7	1.7	1.3	0.7	-0.7	1.4	-2.4	1.4	1.5
Qualifications: College or University degree	1.2	3.9	9.6	-2.3	-3.1	-2.3	2.1	0.2	-2.4	1.8	-1.0	-2.2
Long-standing illness, disability or infirmity	1.2	1.8	2.9	1.6	1.6	1.4	0.1	-1.2	1.7	-1.5	1.5	1.4
Ever smoked	1.2	2.2	8.3	-0.2	-1.3	-1.2	-0.2	-2.9	-0.9	1.4	2.6	-0.8
Alzheimer’s Disease (including proxy)	1.1	1.5	9.9	0.2	0.6	0.3	3.1	1.7	-0.1	-1.0	-1.1	0.2
Crohns Disease (2012)	1.1	1.8	4.2	1.0	1.0	2.0	-0.9	0.6	1.7	-1.5	-2.0	1.4
Triglycerides	1.1	1.8	4.6	1.5	1.6	1.4	-2.1	1.4	1.4	-0.3	-0.3	1.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	7.2	1.1	1.0	0.9	-2.7	-0.4	1.1	-0.1	0.7	0.8
Medication: Metformin	1.1	1.6	5.3	1.2	1.6	1.1	-2.3	-0.5	0.9	-1.1	1.2	1.3
Diabetes (father)	1.1	1.3	3.0	-1.3	-0.8	-1.6	0.5	0.5	-1.7	1.4	-0.2	-1.6
Severe depression (siblings)	1.1	1.2	3.0	-1.0	-1.7	-1.0	-0.8	0.9	-0.8	1.7	-0.6	-1.2
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	5.3	-0.0	0.5	0.7	0.5	2.3	0.4	-1.3	-2.0	0.5
Number of incorrect matches in round	1.1	1.8	4.4	-1.8	-0.7	-1.5	-1.3	-1.0	-1.6	2.1	-0.6	-1.4
Had other major operations	1.1	1.4	3.0	1.7	0.1	1.6	-1.1	-0.9	1.7	-1.1	0.4	1.5
Mouth/teeth dental problems	1.1	1.6	2.8	-1.7	-1.5	-1.5	-0.9	-1.4	-1.3	1.6	-0.3	-1.3
Medication: Ramipril	1.1	1.4	6.3	0.9	2.5	1.2	-1.1	1.4	0.8	-0.6	-0.7	1.0
Exposure to tobacco smoke at home	1.1	1.2	3.0	1.4	0.6	1.0	-1.7	-0.2	1.3	-1.2	1.4	1.0
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.6	1.6	1.2	1.5	0.6	0.9	1.3	-1.2	0.1	1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.7	-0.3	-1.9	-0.9	1.8	-1.3	-0.4	-0.1	1.4	-0.7
Eye problems/disorders: Cataract	1.1	1.3	3.6	1.1	1.9	1.6	0.3	0.5	1.2	-1.6	-0.8	1.1
High cholesterol (Self-reported)	1.1	2.0	5.1	2.3	1.2	1.4	0.0	0.2	1.6	-1.3	2.2	1.6
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.2	-1.8	0.1	-1.1	-0.7	1.1	-1.1	1.1	-1.5	-1.5
Fed-up feelings	1.0	1.8	6.1	-1.6	-0.9	-1.6	2.5	0.7	-1.4	0.7	0.2	-1.8
Age when periods started (menarche)	1.0	2.3	4.3	-2.1	-1.4	-2.0	1.7	-0.2	-2.0	1.4	-0.9	-1.9
Chronic bronchitis/emphysema (father)	1.0	1.1	2.6	-0.8	-1.6	-1.0	1.1	-1.0	-0.9	1.6	1.0	-0.8
Diabetes (self-reported)	1.0	1.5	3.5	1.5	1.9	1.2	-1.9	-0.1	0.9	-1.1	0.8	1.3
Pulse rate	1.0	1.8	3.1	1.5	1.7	1.5	-1.5	1.5	1.6	-1.0	-0.3	1.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	7.1	0.1	-0.4	0.9	1.0	2.7	0.2	-0.6	-2.4	0.2
Medication: Seretide 50 evohaler	1.0	1.2	2.3	-1.4	-0.5	-1.3	1.0	0.1	-1.5	1.5	-0.0	-1.5
Alcohol intake frequency.	1.0	2.3	11.8	1.2	3.4	1.4	-1.2	1.2	0.7	-1.6	-0.7	1.4
Illnesses of father: Heart disease	1.0	1.3	5.9	-1.0	0.1	-0.5	2.4	2.0	-0.6	-0.0	-1.1	-0.6
Neuroticism (Nagel 2018)	0.9	2.0	4.7	-1.4	-1.3	-1.7	2.2	-0.9	-1.1	1.5	1.4	-1.6
LDL Cholesterol	0.9	1.4	4.3	-1.1	-2.1	-1.5	-1.4	0.0	-1.1	1.2	0.4	-1.3
Rheumatoid Arthritis	0.9	1.3	2.7	1.6	1.1	1.4	-0.1	0.7	1.6	-1.2	0.4	1.6
Hypothyroidism (self reported)	0.9	2.0	6.0	-1.2	-2.4	-1.5	1.5	-1.8	-1.5	0.3	0.8	-1.4
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.5	-1.2	-1.0	-0.9	-1.6	0.6	-1.3	0.4	-0.9	-0.9
Waist circumference	0.9	3.1	7.3	2.4	2.7	2.2	-0.7	0.8	2.0	-2.1	0.4	2.0
Past tobacco smoking	0.9	1.6	5.6	0.1	1.7	1.0	-0.1	2.4	0.9	-1.3	-2.0	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.8	1.5	1.2	0.8	0.7	-0.1	1.1	-1.2	2.2	1.2
Happiness	0.9	1.0	2.9	-1.4	-0.9	-1.4	1.7	-0.4	-1.1	0.2	0.1	-1.1
Exposure to tobacco smoke outside home	0.9	1.2	4.3	-1.2	-2.1	-1.0	0.2	-0.1	-0.8	1.3	-0.9	-1.3
Pulse wave peak to peak time	0.9	1.0	3.9	-0.9	-1.2	-1.0	-0.3	-0.2	-1.4	2.0	0.2	-0.9
Number of full sisters	0.9	1.1	2.3	-0.9	-1.4	-1.4	-1.0	-0.5	-1.5	0.7	0.9	-1.2
Had major operations	0.9	1.0	2.1	0.9	1.4	1.3	-1.3	-0.8	1.4	-0.1	0.1	1.0
Guilty feelings	0.9	1.4	4.3	-0.4	-2.1	-1.2	0.9	-1.4	-0.8	0.6	2.0	-0.5
Myopia	0.9	1.3	2.5	-1.3	-1.5	-1.4	1.0	-0.1	-1.3	1.1	-0.7	-1.6
Intelligence (Savage-Jansen 2018)	0.8	2.5	7.5	-1.6	-2.7	-1.8	2.3	0.2	-1.6	0.5	0.1	-1.8
Blood Eosinophil Count	0.8	6.4	11.5	-3.4	-3.1	-3.0	-1.1	1.5	-3.4	2.0	-2.1	-3.3
Ever had hysterectomy (womb removed)	0.8	0.9	2.8	0.4	1.3	0.8	-0.4	1.7	0.4	-1.3	-1.3	0.5
Qualifications: None of the above	0.8	1.7	6.0	1.1	2.4	1.2	-0.2	-0.8	1.4	-1.7	0.9	1.4
Financial difficulties in last 2 years	0.8	1.1	6.6	1.1	-0.3	0.1	-0.7	-1.4	0.4	0.3	2.6	0.4
Heart attack	0.8	1.0	2.8	-1.2	0.4	-1.2	-0.4	0.4	-1.5	1.1	-0.7	-1.7
Pulse wave Arterial Stiffness index	0.8	0.9	3.4	0.8	1.1	1.0	0.1	0.2	1.3	-1.9	-0.4	0.8
Pulse wave reflection index	0.8	1.0	3.1	-1.3	-1.3	-1.1	1.8	0.2	-0.9	0.2	-0.7	-1.1
Eye problems/disorders: None of the above	0.8	0.9	1.7	-1.2	-1.2	-1.3	1.3	0.6	-0.9	0.3	0.3	-1.2
Medication: Allopurinol	0.8	1.0	3.2	0.9	0.4	1.0	-1.5	0.7	1.3	-1.8	-0.4	0.6
Pulse rate, automated reading	0.8	2.6	4.7	2.0	1.6	1.9	-1.5	2.2	1.8	-1.7	-0.0	1.8
Back pain experienced in last month	0.8	1.1	4.2	1.1	0.3	0.7	-0.7	-1.4	1.2	-0.2	2.0	1.2
Medication: Gliclazide	0.8	0.9	4.2	0.7	0.9	0.7	-2.0	-0.1	0.9	-0.6	0.7	0.8
Wears glasses or contact lenses	0.8	0.9	3.3	-0.4	-0.6	-0.9	1.1	-1.8	-0.3	0.7	1.6	-0.6
Medication: Lisinopril	0.8	1.1	2.4	1.4	0.8	1.3	-0.2	1.0	1.5	-1.1	0.4	1.2
Neuroticism (2016)	0.7	1.1	8.3	0.2	-0.3	-0.3	2.9	0.7	-0.3	0.1	1.3	-0.3
Frequency of depressed mood in last 2 weeks	0.7	0.9	5.1	0.8	0.5	0.2	0.3	-1.4	0.8	-0.6	2.2	0.6
Hand grip strength (right)	0.7	2.0	6.1	-1.5	-2.5	-1.6	1.8	0.0	-1.2	1.5	0.6	-1.5
Pain all over the body in last month	0.7	0.7	3.2	0.7	1.0	0.6	-1.1	-0.3	0.7	-1.8	0.5	0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.8	-1.0	-0.9	-0.9	-0.0	1.7	-1.0	0.3	-1.1	-1.1
Falls in the last year	0.7	1.0	2.2	-1.1	-0.7	-1.2	1.5	-0.7	-1.2	0.4	-0.1	-1.4
Birth weight	0.7	1.6	4.5	-1.5	-1.3	-1.7	-0.3	-0.5	-2.1	1.6	-0.4	-1.3
Number of children fathered	0.7	0.8	2.4	1.1	0.9	1.2	0.1	1.0	1.5	-0.4	-0.0	1.0
Medication: Omeprazole	0.7	0.9	1.5	1.2	1.0	1.2	1.2	0.9	1.1	-1.0	-0.3	0.6
Age at last live birth	0.7	1.0	4.1	0.7	0.0	1.0	0.4	2.0	0.9	-1.1	-1.3	0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.4	-1.3	-0.5	-0.5	1.5	0.6	-0.6	-0.2	-1.4	-0.8
Hypertension (Self-reported)	0.7	2.1	4.3	1.8	2.1	1.9	0.4	0.2	2.0	-1.2	0.4	1.9
Mood swings	0.7	1.2	2.6	-1.2	-1.4	-1.2	1.3	0.7	-0.9	1.6	0.3	-1.2
Medication for cholesterol	0.7	1.1	3.7	-1.2	-1.9	-1.1	0.7	-0.2	-1.2	0.3	-1.0	-1.2
Osteoporosis (self-reported)	0.7	0.9	3.8	0.2	1.9	0.7	-1.5	0.3	0.1	-0.6	-1.4	0.3
Miserableness	0.7	1.3	2.0	-1.2	-1.4	-1.4	1.2	-0.2	-0.9	1.3	1.3	-1.2
Pack years of smoking	0.7	1.0	2.9	0.8	1.3	0.7	1.7	0.6	0.8	-1.6	0.5	0.8
Waist Hip Ratio (WHR)	0.6	2.7	5.7	2.4	1.7	2.1	-1.1	1.7	2.0	-1.6	0.3	1.9
Smoking Status	0.6	1.3	9.7	0.9	-0.4	-0.1	0.2	-1.5	0.3	-0.1	3.1	0.4
Hand grip strength (left)	0.6	1.6	9.2	-1.0	-3.0	-1.2	0.5	0.7	-0.7	1.2	0.5	-1.1
Sensitivity / hurt feelings	0.6	1.0	7.1	-0.1	0.3	-0.4	2.7	-0.7	-0.4	0.2	1.6	0.0
Pack years adult smoking proportion	0.6	1.0	3.0	0.7	1.1	0.5	1.7	0.6	0.7	-1.7	0.7	0.7
Had menopause	0.6	0.7	2.1	0.3	1.4	0.9	-0.7	0.7	0.6	-1.1	-1.2	0.8
Neuroticism score	0.6	1.2	5.4	0.1	-0.8	-0.4	2.2	-1.1	0.3	-0.0	2.3	0.1
Time employed in main current job	0.6	0.7	4.4	-0.8	-0.2	-0.7	2.1	-0.1	-0.5	0.2	0.4	-0.7
Worrier / anxious feelings	0.6	1.1	6.0	0.1	-0.1	-0.5	0.8	-1.7	0.1	1.1	2.5	-0.1
High blood pressure (siblings)	0.6	0.9	4.6	-0.2	0.7	0.4	2.1	0.7	0.4	-1.4	-1.2	-0.0
Neck or shoulder pain in last month	0.6	0.9	3.4	0.2	-1.0	-0.5	-0.8	-1.0	0.1	1.8	1.6	-0.1
Overall health rating	0.6	1.3	4.9	1.4	2.2	0.9	0.1	-0.2	1.0	-0.4	1.7	1.1
Leg pain on walking	0.6	0.7	2.5	0.3	1.5	0.5	0.8	1.6	0.7	0.1	-0.9	0.2
Medication: Aspirin	0.6	0.8	1.5	1.2	1.2	1.2	-0.2	1.1	0.8	-0.8	-0.5	0.9
Smoking status: Previous	0.6	0.8	3.4	0.5	-1.3	-0.2	-0.2	-1.8	-0.3	0.4	1.6	-0.0
Asthma (self-reported)	0.6	1.2	2.5	-0.9	-0.6	-0.6	-1.3	1.3	-1.2	1.6	-1.5	-0.9
Medication: Bendroflumethiazide	0.6	1.0	2.2	0.7	1.3	1.1	1.5	-0.0	1.2	-0.9	-0.0	1.2
Average weekly beer plus cider intake	0.6	0.9	4.6	-0.8	-0.9	-1.0	-0.6	0.2	-0.6	2.1	0.1	-1.0
Fractured/broken bones in last 5 years	0.6	0.8	1.5	-1.2	-0.0	-1.1	0.4	-1.1	-1.1	1.0	-0.1	-1.2
Commuting to job workplace: Cycle	0.6	0.7	3.0	-0.9	0.3	-0.4	-0.3	1.4	-0.8	0.6	-1.7	-0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	-1.0	0.4	-1.0	-0.5	0.4	-1.3	1.0	-0.5	-1.5
Depression (Nagel 2018)	0.5	0.7	3.0	0.6	0.3	0.3	0.0	-1.3	0.7	-1.0	1.7	0.4
Major Depression (MDD)	0.5	0.6	2.1	-0.4	-0.6	-0.6	-1.5	-1.3	0.0	0.3	0.5	-0.7
Blood Platelet Count	0.5	6.3	26.8	2.2	1.0	2.6	-5.2	3.0	1.9	-0.8	-1.6	2.8
Allergy or Eczema	0.5	1.4	5.1	-0.6	-2.2	-1.3	0.3	-1.7	-1.1	0.1	1.3	-1.0
Respiratory disease	0.5	1.1	3.0	-0.9	-1.2	-0.5	0.1	1.5	-1.0	1.1	-1.7	-1.0
Chronotype (morning person)	0.5	1.2	3.4	1.4	0.9	1.2	-0.6	-0.7	1.1	-1.8	1.0	1.2
Impedance of leg (right)	0.5	2.6	5.5	-1.9	-2.3	-1.7	0.1	1.2	-1.3	2.2	-1.5	-2.0
Qualifications: CSEs or equivalent	0.5	0.6	2.3	-0.4	-0.0	-1.0	-0.8	-0.2	-0.6	1.5	0.9	-1.0
High blood pressure	0.5	1.5	4.0	1.5	2.0	1.6	0.3	-0.2	1.6	-1.0	0.4	1.5
Fluid intelligence score	0.5	1.1	5.8	-0.8	-2.4	-1.1	1.0	0.2	-1.2	0.1	0.3	-1.1
Father’s age at death	0.5	0.6	3.5	0.8	-0.1	0.7	-1.9	-0.2	0.8	-0.4	0.3	0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.6	-0.7	-1.1	-0.1	1.5	1.5	-0.7	-0.7	-1.9	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	2.4	-0.4	-1.6	-0.4	-0.4	0.9	-0.8	0.1	-1.0	-0.3
Asthma	0.5	1.0	2.5	-0.8	-0.5	-0.4	-1.2	1.3	-1.0	1.3	-1.6	-0.8
Peak expiratory flow (PEF)	0.5	1.2	2.7	-1.2	-0.8	-0.9	0.9	1.6	-1.3	1.1	-1.4	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	4.5	0.6	0.4	0.3	0.7	2.1	-0.1	0.5	-0.3	0.4
Blood clot in the leg (DVT)	0.5	0.7	3.0	0.1	-0.4	-0.4	-0.8	-1.7	-0.1	0.4	1.6	-0.0
Medication: Amlodipine	0.5	0.6	1.3	0.8	1.0	0.7	-1.1	1.1	0.3	-1.0	-0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.5	-0.6	-0.8	-0.7	1.1	0.7	-0.3	1.6	-0.3	-1.1
Wheeze or whistling in the chest in last year	0.5	0.8	2.0	-0.9	-0.7	-0.7	-1.0	1.1	-0.7	1.4	-0.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.4	-0.4	-0.1	0.0	0.3	1.8	-0.2	0.0	-1.4	-0.4
Age at first live birth	0.5	0.9	4.7	0.4	0.1	1.0	-0.2	2.2	0.6	-0.4	-1.6	0.4
Shortness of breath walking on level ground	0.5	0.6	1.6	0.8	0.9	0.6	-1.0	-0.1	0.7	-0.5	1.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.5	-0.6	-1.4	-0.8	-1.5	0.2	-0.7	1.9	-0.0	-0.8
Ever had bowel cancer screening	0.5	0.6	3.0	0.3	1.7	0.6	-1.1	-0.3	0.6	0.1	-0.8	0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.5	0.9	1.2	0.9	1.2	0.4	1.1	-0.2	0.7	0.5
Diastolic blood pressure, automated reading	0.5	1.5	4.7	1.6	0.7	1.8	-0.4	0.3	2.2	-1.1	-0.1	1.7
Crohns Disease (2017)	0.4	0.9	2.4	0.7	0.4	1.5	-0.2	0.5	1.4	-0.8	-1.5	0.8
Reaction Time	0.4	0.8	1.8	-1.3	-0.4	-0.8	0.1	-0.9	-0.8	1.0	-1.3	-0.9
Blood White Count	0.4	2.7	12.9	-1.4	-0.1	-1.1	0.4	3.6	-1.5	1.3	-2.1	-1.7
Height	0.4	7.9	59.8	1.3	2.7	1.6	-7.7	-1.3	1.7	1.4	0.1	1.3
Lung FEV1/FVC ratio	0.4	2.0	10.6	1.2	1.4	0.9	-0.2	3.3	0.4	-1.8	-0.6	1.0
Neuroticism	0.4	1.0	4.0	-0.6	-1.0	-0.8	2.0	-0.7	-0.4	0.3	1.7	-0.6
Diabetes (mother)	0.4	0.6	5.0	-0.2	0.2	0.1	-2.2	0.0	0.1	-0.5	-0.5	0.3
Leg fat-free mass (left)	0.4	2.0	9.4	1.4	1.7	1.2	-3.1	-0.6	1.0	-0.8	0.9	1.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.7	-0.0	-1.7	-0.7	-0.3	-1.4	-0.4	-0.0	1.6	-0.6
Stomach or abdominal pain in last month	0.4	0.6	2.1	0.8	0.4	0.6	1.4	0.9	0.5	-1.0	-0.0	0.4
Medication: Levothyroxine sodium	0.4	0.7	3.0	1.0	-0.2	0.4	-0.1	-1.7	0.7	0.1	1.4	0.5
Impedance of leg (left)	0.4	1.9	3.7	-1.6	-1.9	-1.2	0.2	1.4	-0.8	1.8	-1.9	-1.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	-1.1	0.1	-0.8	-0.1	0.7	-0.8	0.6	-0.8	-1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	3.0	-0.0	-0.7	-0.2	1.7	-0.5	0.4	-0.0	0.8	0.0
Medication: Lansoprazole	0.4	0.5	1.1	-0.8	-0.6	-0.9	0.3	0.2	-1.0	0.9	-0.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.2	-1.2	-2.1	-1.1	-0.1	1.2	-1.1	1.0	-0.9	-1.1
Standing height	0.4	3.6	29.1	-0.3	1.1	0.3	-5.4	0.2	-0.0	1.6	-1.8	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	-0.9	-0.3	-1.1	0.7	-0.1	-1.1	1.3	-0.1	-1.0
Emphysema/chronic bronchitis	0.4	0.5	1.3	0.1	0.8	1.0	0.2	0.6	1.1	-0.7	-1.1	0.3
Angina (self-reported)	0.4	0.5	2.4	0.8	0.7	0.2	0.1	-0.8	0.6	-0.4	1.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.7	0.9	1.3	0.7	-0.5	0.6	0.3	0.6	-0.0	0.5
Supplements: Vitamin C	0.4	0.5	1.2	0.6	0.7	0.8	0.8	0.2	0.8	-1.1	-0.3	0.6
Leg fat-free mass (right)	0.4	2.0	8.4	1.4	1.9	1.3	-2.9	-0.5	1.1	-1.0	0.6	1.3
Qualifications: nursing, teaching	0.4	0.7	4.5	0.1	-1.1	0.1	2.1	0.4	-0.2	-0.8	-0.1	0.2
Leg predicted mass (right)	0.4	2.2	8.6	1.5	1.9	1.4	-2.9	-0.6	1.2	-1.1	0.7	1.4
Financial situation satisfaction	0.4	0.5	1.4	0.8	0.5	0.5	1.2	0.3	0.7	-1.0	0.9	0.6
Commuting to job workplace: Public transport	0.4	0.4	1.9	-0.2	0.3	0.4	-0.9	1.0	0.4	0.3	-1.4	0.2
Medication: Blood pressure	0.4	0.7	1.5	0.8	1.2	1.0	-0.3	0.8	0.9	-1.1	-0.2	1.0
Medication: Atorvastatin	0.4	0.5	1.1	-0.8	-1.0	-0.6	-0.9	0.5	-0.6	0.8	-0.8	-0.6
Unable to work because of sickness or disability	0.4	0.5	1.0	0.8	0.8	0.9	0.3	0.9	0.6	-1.0	-0.4	0.6
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.9	-1.3	-1.7	-1.1	-0.2	0.7	-1.3	0.8	-1.1	-1.2
Heart disease (siblings)	0.4	0.5	1.2	0.6	1.1	0.7	-1.1	-0.2	0.8	-0.4	0.3	0.9
Depressed Affect (Nagel 2018)	0.3	0.6	1.6	-0.8	-0.6	-0.9	1.3	-0.2	-0.5	0.6	1.0	-1.1
Ovarian Cancer	0.3	0.4	1.5	-0.1	1.0	0.1	-1.1	-0.2	-0.1	-0.5	-1.2	-0.2
Age at First Birth	0.3	0.5	1.7	-0.8	-0.8	-0.6	0.7	0.6	-0.3	1.3	0.4	-0.6
Fasting Glucose	0.3	0.3	1.1	-0.4	-0.5	-0.5	0.7	0.5	-0.5	1.1	0.1	-0.6
HDL Cholesterol	0.3	0.4	1.4	-0.8	-0.6	-0.3	0.2	0.7	-0.5	0.7	-1.2	-0.9
Schizophrenia (2014)	0.3	0.6	2.4	0.5	0.5	0.8	-0.7	1.6	0.5	-0.1	-1.2	0.8
Systolic Blood Pressure	0.3	1.5	3.7	1.8	-0.1	1.5	-0.8	1.3	1.9	-0.9	0.8	1.5
Number of treatments/medications taken	0.3	0.5	1.8	0.0	-0.5	-0.6	0.8	-0.7	-0.7	0.9	1.4	-0.6
Angina	0.3	0.3	1.7	0.6	0.6	0.1	0.1	-0.7	0.4	-0.4	1.3	0.2
Medication for hormone replacement therapy	0.3	0.3	1.4	-0.1	1.2	0.1	-0.3	0.8	0.2	1.0	-0.5	0.0
Vitamin and mineral supplements	0.3	0.4	1.3	0.5	0.6	0.6	-0.9	1.2	0.5	0.1	-0.5	0.6
Maternal smoking around birth	0.3	0.5	1.3	0.1	1.0	0.2	-0.5	-0.8	0.7	-1.1	1.1	0.5
Relative age voice broke	0.3	0.5	2.3	0.1	1.0	0.5	0.3	1.5	0.6	-0.8	-0.7	0.3
Body mass index (BMI)	0.3	1.1	2.2	1.5	1.3	1.2	0.1	0.2	1.1	-1.5	1.0	1.2
Leg predicted mass (left)	0.3	1.9	9.2	1.4	1.6	1.1	-3.0	-0.5	0.9	-0.7	0.8	1.1
Illnesses of siblings	0.3	0.5	0.9	-0.2	-0.9	-0.7	-0.7	-0.9	-0.5	0.9	0.9	-0.5
Weight	0.3	1.6	5.0	1.4	1.9	1.4	-2.2	0.5	1.1	-0.8	0.1	1.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.5	-1.0	-1.3	-0.6	-0.5	1.6	-0.8	0.8	-1.5	-0.8
Medication: Cholesterol lowering	0.3	0.5	1.3	1.1	0.9	0.6	0.4	0.7	0.5	-0.4	1.0	0.7
Depression (self-reported)	0.3	0.3	1.7	-0.3	-0.4	-0.5	1.3	-0.4	-0.3	-0.7	0.4	-0.4
Illnesses of mother	0.3	0.4	1.1	-0.6	-0.6	-0.4	-1.0	0.9	-0.8	0.2	-0.7	-0.4
Tense / ‘highly strung’	0.3	0.4	1.0	0.8	-0.0	0.6	0.7	0.0	1.0	-0.5	0.7	0.9
Medication: Paracetamol	0.3	0.5	2.4	0.1	-0.5	-0.5	-0.0	-0.9	-0.3	0.9	1.6	-0.4
Headache pain in last month	0.3	0.6	3.5	-0.3	-0.6	-0.5	1.9	0.6	-0.7	0.5	-0.0	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	3.2	0.3	-0.8	-0.1	0.6	-1.8	0.0	-0.7	1.0	0.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.1	-0.5	1.0	-0.2	-0.0	0.2	-0.5	-1.1	-0.3	-0.4
Forced vital capacity (FVC), Best measure	0.3	1.0	4.5	-1.1	-2.1	-0.9	-0.3	0.2	-0.8	1.4	-0.7	-0.9
Arm fat-free mass (right)	0.3	1.5	6.0	1.2	1.5	1.3	-2.5	0.6	1.3	-0.7	0.0	1.1
Arm predicted mass (right)	0.3	1.4	5.4	1.1	1.4	1.2	-2.3	0.6	1.3	-0.8	-0.0	1.1
Comparative height size at age 10	0.3	1.8	14.5	-0.3	0.9	0.2	-3.8	0.1	-0.2	1.1	-1.0	0.1
Whole body fat-free mass	0.3	1.6	8.9	1.0	1.5	1.0	-3.0	-0.1	1.0	-0.5	0.3	1.0
Friendships satisfaction	0.3	0.3	1.8	-0.4	0.2	-0.2	1.3	-0.1	-0.4	-1.0	-0.2	-0.0
Commuting to job workplace: Walk	0.3	0.3	1.2	0.0	0.5	0.5	-0.7	-0.4	0.3	-0.3	-1.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.2	-0.0	-1.0	0.6	0.2	1.5	0.5	-0.7	-1.4	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.9	0.2	0.6	-0.2	0.7	-1.4	-0.6	-0.1	0.6	0.1
Alcohol drinker status: Never	0.3	0.3	0.8	-0.8	0.7	-0.6	-0.2	0.9	-0.4	0.5	-0.7	-0.5
Basal metabolic rate	0.3	1.4	7.6	1.1	1.4	1.1	-2.8	0.0	1.0	-0.6	0.3	1.0
Arm fat-free mass (left)	0.3	1.6	5.3	1.3	1.5	1.3	-2.3	0.5	1.3	-0.9	0.1	1.3
Age started oral contraceptive pill	0.3	0.4	1.0	0.4	0.9	0.6	-0.8	-0.2	0.3	-0.8	-0.2	1.0
Ever depressed for a whole week	0.3	0.3	0.9	0.6	0.2	0.3	0.4	-1.0	0.5	0.5	0.9	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.8	-0.5	0.2	-0.4	0.2	1.4	-0.7	0.4	-0.8	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.7	0.2	-0.2	-0.3	-0.9	-1.3	-0.1	0.5	1.3	-0.1
Impedance of whole body	0.3	1.6	3.2	-1.5	-1.3	-1.1	-0.3	0.9	-1.1	1.7	-1.8	-1.5
Leg fat mass (left)	0.3	1.0	2.2	1.3	1.5	1.1	-1.3	0.0	1.0	-0.9	0.8	1.0
Schizophrenia (2018)	0.2	0.3	2.6	0.5	-0.1	0.4	0.1	1.6	0.2	0.0	-0.2	0.6
Worry (Nagel 2018)	0.2	0.4	1.1	-0.4	-0.3	-0.5	1.0	-0.6	-0.1	1.0	0.7	-0.4
Prostate Cancer	0.2	0.3	1.3	-0.2	-1.2	-0.2	-0.2	-1.0	0.1	-0.5	0.3	0.1
Mean Putamen Volume	0.2	0.3	0.8	0.1	0.5	-0.3	-0.9	-0.6	-0.2	0.5	0.9	-0.1
Lupus	0.2	0.3	1.1	0.7	-0.1	0.7	-0.1	0.7	1.0	0.1	-0.1	0.5
Primary Biliary Cirrhosis	0.2	0.3	1.1	-0.3	-0.0	-0.1	-0.2	1.0	-0.7	0.6	-0.8	-0.1
Heel T-Score	0.2	1.4	7.2	0.8	-0.6	1.0	-2.7	1.1	1.3	0.1	-0.9	1.1
Cardiovascular Disease	0.2	0.7	1.8	-0.3	-0.2	-0.9	1.3	0.4	-0.7	1.3	1.1	-0.8
Hearing difficulty/problems: Yes	0.2	0.3	1.4	-0.5	-0.6	-0.4	1.2	-0.5	-0.2	-0.1	0.1	-0.4
Supplements: Zinc	0.2	0.2	0.4	-0.6	-0.2	-0.5	-0.6	-0.6	-0.3	-0.1	0.2	-0.5
Trunk fat percentage	0.2	0.8	2.1	1.2	1.4	1.1	-0.6	0.6	0.8	-0.8	0.2	0.8
Current tobacco smoking	0.2	0.3	1.5	0.3	0.5	0.0	-0.8	0.1	0.3	-0.4	1.2	0.2
Taking other prescription medications	0.2	0.3	1.2	0.1	0.8	-0.1	0.7	-1.1	0.3	0.1	0.6	-0.3
High blood pressure (mother)	0.2	0.3	1.0	1.0	0.2	0.6	0.6	-0.4	0.7	0.4	0.1	0.7
Trunk fat mass	0.2	0.9	2.7	1.2	1.6	1.1	-1.3	0.5	0.9	-0.6	0.2	0.9
Alcohol usually taken with meals	0.2	0.3	0.9	-0.5	-0.7	-0.6	-0.4	0.8	-0.9	0.5	-0.5	-0.4
Hearing difficulty/problems with background noise	0.2	0.3	1.6	0.0	0.5	0.4	0.3	0.4	0.5	-0.3	-1.3	0.1
Forced vital capacity (FVC)	0.2	0.8	1.9	-0.9	-1.4	-0.5	-0.9	0.6	-0.5	1.1	-1.2	-0.7
Impedance of arm (right)	0.2	0.9	2.1	-1.1	-0.9	-1.0	-0.6	-0.7	-1.2	1.4	-0.8	-1.1
Arm fat percentage (right)	0.2	0.8	2.2	1.3	1.5	1.0	-0.0	0.1	0.7	-1.0	0.8	0.9
Trunk fat-free mass	0.2	1.1	7.9	0.6	1.2	0.7	-2.8	-0.0	0.7	-0.1	-0.0	0.7
Hip circumference	0.2	0.7	2.3	0.7	1.5	0.7	-1.2	-0.2	0.7	-1.0	0.5	0.5
Alcohol intake versus 10 years previously	0.2	0.3	1.9	0.2	0.2	-0.4	0.2	-0.8	-0.2	0.1	1.4	0.1
Noisy workplace	0.2	0.2	1.0	0.0	-0.0	-0.2	0.6	-0.5	-0.0	-0.5	1.0	-0.2
Lung cancer (father)	0.2	0.2	0.9	-0.2	0.3	0.1	-0.6	0.4	0.1	0.4	-0.9	-0.0
Trunk predicted mass	0.2	1.1	7.8	0.6	1.2	0.7	-2.8	0.1	0.8	-0.1	-0.0	0.7
Birth weight of first child	0.2	0.3	1.6	-0.1	0.1	-0.3	0.2	1.2	-0.9	-0.1	-0.6	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.3	-0.1	-0.0	0.4	-1.0	0.1	-0.0	-0.6	-1.1	0.3
Body fat percentage	0.2	0.8	2.2	1.3	1.5	1.1	-0.5	0.7	0.9	-0.9	0.2	0.9
Comparative body size at age 10	0.2	0.6	1.8	-0.5	0.2	-0.7	1.3	-1.0	-1.0	-0.9	1.0	-0.3
Number of full brothers	0.2	0.3	1.1	0.5	-0.3	0.8	-0.2	0.5	1.0	-0.5	-0.1	0.7
Mean time to correctly identify matches	0.2	0.3	1.3	-0.7	0.3	-0.2	-0.3	-0.9	-0.1	0.6	-1.1	-0.3
Heart disease (mother)	0.2	0.3	1.3	0.3	1.1	0.5	0.9	-0.1	0.6	0.2	-0.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	0.8	0.3	0.8	-0.1	0.1	0.6	-0.6	0.1	0.6
Whole body fat mass	0.2	0.8	2.2	1.1	1.5	0.9	-1.3	0.5	0.8	-0.7	0.3	0.7
Leg fat mass (right)	0.2	0.9	1.7	1.3	1.3	1.0	-1.3	0.1	0.9	-0.8	0.9	0.9
Suffer from ‘nerves’	0.2	0.3	2.2	-0.2	-0.1	-0.2	1.5	0.3	-0.1	-0.3	0.2	-0.2
Chest pain or discomfort	0.2	0.3	1.3	0.6	1.2	0.3	0.0	1.1	0.1	0.5	-0.1	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.4	0.3	-0.5	0.1	-1.2	0.3	0.1	-0.4	0.5	0.1
Illnesses of siblings: Diabetes	0.2	0.2	1.1	-0.0	-0.3	0.3	-0.5	0.5	-0.0	-0.3	-1.0	0.2
Arm fat percentage (left)	0.2	0.8	2.4	1.3	1.6	1.0	-0.1	0.3	0.7	-0.9	0.7	0.9
Osteoarthritis (self-reported)	0.2	0.2	0.7	-0.2	-0.9	-0.4	-0.2	0.0	-0.3	0.4	0.7	-0.6
Smoking status: Current	0.2	0.3	1.5	-0.3	0.0	-0.6	-0.5	-0.1	-0.4	0.4	1.2	-0.4
Whole body water mass	0.2	1.4	8.0	0.9	1.4	1.0	-2.8	-0.0	0.9	-0.5	0.2	0.9
Arm fat mass (left)	0.2	0.8	2.1	1.2	1.5	1.0	-0.7	0.4	0.8	-1.0	0.6	0.9
Average weekly champagne plus white wine intake	0.2	0.3	1.2	0.0	-0.6	-0.2	0.6	-1.1	-0.3	0.7	0.3	-0.1
Ever taken oral contraceptive pill	0.2	0.2	1.0	-0.2	-0.8	-0.2	1.0	-0.0	0.1	-0.5	0.0	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	-0.7	-0.3	-0.6	0.5	-0.5	-0.5	0.1	-0.2	-0.6
Medication: Paracetamol	0.2	0.3	2.0	0.6	-0.1	0.0	-0.2	-0.8	0.1	0.3	1.4	0.3
Leg fat percentage (left)	0.2	0.6	1.5	1.0	1.2	0.8	0.2	0.6	0.9	-0.9	0.4	0.7
Risk taking	0.2	0.3	2.0	0.3	0.3	0.4	-1.4	0.1	0.1	-0.0	-0.6	0.3
Supplements: Calcium	0.2	0.2	0.7	-0.0	0.4	0.3	-0.7	0.3	0.4	-0.1	-0.9	-0.0
Arm predicted mass (left)	0.2	1.1	5.3	0.8	1.2	0.9	-2.3	0.6	1.0	-0.5	-0.1	0.8
Irritable Bowel Disease (IBD)	0.1	0.3	1.0	0.3	0.1	0.9	-0.4	0.5	1.0	-0.1	-0.8	0.2
Ulcerative Colitis (UC)	0.1	0.2	0.8	-0.3	-0.7	-0.2	-0.3	-0.1	-0.0	0.9	0.2	-0.6
Ulcerative Colitis	0.1	0.2	0.4	-0.0	0.3	0.3	-0.5	0.6	0.1	0.6	-0.6	-0.1
Blood Red Count	0.1	1.0	2.6	-0.7	-1.6	-0.3	0.9	1.5	-0.7	-0.5	-1.6	-0.6
BMI	0.1	0.5	3.0	0.4	0.8	0.2	1.7	0.1	-0.2	-1.0	0.6	0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	0.1	0.7	0.0	-0.5	-0.6	-0.2	-0.1	0.8	0.3
Lung FVC	0.1	0.7	2.9	0.6	-0.7	0.5	0.7	-1.7	0.8	-0.7	0.6	0.9
Tanning	0.1	0.8	3.0	-0.2	-0.8	-0.7	-1.7	-1.4	-0.6	0.3	1.1	-0.3
Relative age of first facial hair	0.1	0.3	0.8	0.2	0.1	0.5	-0.7	0.7	0.4	-0.9	-0.2	0.6
Medication: Co-codamol	0.1	0.1	0.6	-0.1	0.5	-0.1	-0.2	0.8	-0.0	0.4	-0.3	-0.2
Serious illness, injury or assault to yourself	0.1	0.2	0.5	0.6	0.7	0.1	-0.3	-0.6	0.1	-0.1	0.7	0.2
Sitting height	0.1	0.5	3.4	0.1	1.0	0.2	-1.9	-0.1	0.1	0.7	-0.7	0.0
Allergy	0.1	0.3	0.8	0.4	0.9	0.5	0.8	0.3	0.6	-0.4	-0.1	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	-0.1	0.2	-0.1	-0.5	-0.0	0.1	0.7	0.3	-0.2
Impedance of arm (left)	0.1	0.6	1.0	-0.9	-0.6	-0.7	-0.7	-0.2	-0.9	1.0	-1.0	-0.9
Arm fat mass (right)	0.1	0.6	1.7	1.1	1.3	0.8	-0.8	-0.1	0.6	-0.6	0.8	0.7
Hair/balding pattern: Pattern 4	0.1	0.2	1.5	-0.3	-0.1	0.2	-0.5	1.2	0.2	0.3	-0.6	0.2
Glaucoma (self-reported)	0.1	0.1	0.2	0.4	0.3	0.4	-0.1	0.0	0.4	-0.2	0.2	0.3
Leg fat percentage (right)	0.1	0.4	0.9	0.9	0.9	0.6	0.1	0.5	0.6	-0.6	0.5	0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.8	-0.3	-0.2	-0.2	-0.4	-0.5	-0.0	-0.9	0.0	0.1
Medication: Blood pressure	0.1	0.2	0.9	0.4	0.9	0.2	0.8	-0.1	0.4	0.5	0.4	0.1
Family relationship satisfaction	0.1	0.1	0.9	-0.2	-0.1	0.0	0.4	0.1	0.1	-0.9	-0.2	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	1.0	0.4	-0.4	0.3	-0.3	0.3	1.0	0.1	0.7	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	-0.5	0.4	-0.4	-0.1	-0.4	-0.2	0.4	-0.0	-0.6
Mineral and other dietary supplements	0.1	0.1	0.2	0.5	0.3	0.4	0.1	0.4	0.4	0.2	0.0	0.4
Eye problems/disorders: Glaucoma	0.1	0.2	0.6	-0.5	-0.2	-0.5	-0.1	0.2	-0.6	0.8	-0.2	-0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	0.1	0.0	-0.0	-0.4	-0.6	0.1	0.6	0.5	-0.2
Hair Pigment	0.0	0.4	1.4	1.2	0.5	0.6	0.1	-0.3	0.6	0.0	1.1	0.7

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