Best TWAS P=7.37e-81 · Best GWAS P=6.59e-79 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ARFGEF2 | 0.09 | 0.05 | lasso | 8 | 0.10 | 9.2e-13 | 18.0 | -17.9 | 1.2e-71 | -0.82 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | CSE1L | 0.08 | 0.07 | bslmm | 503 | 0.05 | 1.7e-06 | -7.2 | -11.7 | 1.1e-31 | -0.58 | 0.92 | 0.08 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | DDX27 | 0.04 | 0.04 | enet | 11 | 0.07 | 7.3e-09 | -6.4 | 5.8 | 6.6e-09 | 0.26 | 0.96 | 0.01 | FALSE |
4 | CommonMind | Brain Pre-frontal Cortex | SLC9A8 | 0.15 | 0.05 | enet | 26 | 0.09 | 2.3e-11 | 2.4 | 6.1 | 9.8e-10 | 0.00 | 1.00 | 0.00 | FALSE |
5 | CommonMind | Brain Pre-frontal Cortex | STAU1 | 0.09 | 0.00 | bslmm | 500 | 0.01 | 8.7e-03 | -5.6 | -6.4 | 1.3e-10 | -0.30 | 0.26 | 0.06 | TRUE |
6 | GTEx | Adipose Subcutaneous | ARFGEF2 | 0.10 | 0.07 | lasso | 3 | 0.06 | 1.1e-05 | -6.6 | -6.5 | 1.1e-10 | -0.42 | 0.94 | 0.04 | FALSE |
7 | GTEx | Adipose Subcutaneous | CSE1L | 0.15 | 0.15 | lasso | 4 | 0.15 | 2.4e-12 | -6.3 | -6.4 | 1.7e-10 | -0.42 | 1.00 | 0.00 | FALSE |
8 | GTEx | Adipose Visceral Omentum | ZFP64 | 0.17 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | 6.2 | 5.3 | 1.1e-07 | -0.03 | 0.08 | 0.07 | TRUE |
9 | GTEx | Adipose Visceral Omentum | CSE1L | 0.13 | 0.02 | enet | 19 | 0.05 | 2.1e-03 | -6.0 | -6.4 | 1.6e-10 | -0.42 | 0.27 | 0.07 | FALSE |
10 | GTEx | Artery Aorta | CSE1L | 0.12 | 0.18 | lasso | 4 | 0.16 | 2.9e-09 | -7.2 | -7.3 | 2.2e-13 | -0.44 | 0.92 | 0.08 | FALSE |
11 | GTEx | Artery Tibial | CSE1L | 0.12 | 0.03 | lasso | 6 | 0.04 | 3.8e-04 | -6.6 | -11.6 | 2.3e-31 | -0.68 | 0.30 | 0.68 | FALSE |
12 | GTEx | Brain Cerebellar Hemisphere | DDX27 | 0.30 | 0.07 | lasso | 9 | 0.03 | 4.8e-02 | -7.1 | -7.8 | 8.0e-15 | -0.27 | 0.07 | 0.09 | FALSE |
13 | GTEx | Brain Nucleus accumbens basal ganglia | BCAS4 | 0.33 | 0.01 | lasso | 7 | 0.00 | 4.6e-01 | 8.4 | -9.8 | 8.9e-23 | -0.01 | 0.07 | 0.07 | TRUE |
14 | GTEx | Brain Nucleus accumbens basal ganglia | SLC9A8 | 0.42 | 0.09 | lasso | 7 | 0.08 | 3.8e-03 | -9.4 | 8.5 | 1.5e-17 | -0.06 | 0.07 | 0.11 | FALSE |
15 | GTEx | Cells Transformed fibroblasts | ZFP64 | 0.09 | 0.09 | enet | 5 | 0.09 | 1.9e-07 | -4.2 | 6.2 | 4.0e-10 | -0.04 | 0.84 | 0.07 | TRUE |
16 | GTEx | Cells Transformed fibroblasts | STAU1 | 0.08 | 0.03 | lasso | 6 | 0.02 | 2.3e-02 | 14.7 | 16.4 | 9.4e-61 | 0.85 | 0.03 | 0.92 | FALSE |
17 | GTEx | Cells Transformed fibroblasts | ZFAS1 | 0.06 | 0.05 | enet | 5 | 0.03 | 2.6e-03 | -10.1 | 10.1 | 7.3e-24 | 0.29 | 0.41 | 0.27 | FALSE |
18 | GTEx | Colon Sigmoid | ARFGEF2 | 0.15 | 0.12 | lasso | 1 | 0.07 | 2.3e-03 | 13.7 | -13.7 | 1.3e-42 | -0.60 | 0.05 | 0.61 | FALSE |
19 | GTEx | Colon Sigmoid | CSE1L | 0.18 | 0.12 | lasso | 11 | 0.09 | 4.4e-04 | 15.8 | -16.1 | 5.7e-58 | -0.80 | 0.10 | 0.86 | FALSE |
20 | GTEx | Colon Transverse | ARFGEF2 | 0.11 | 0.07 | enet | 12 | 0.09 | 2.9e-05 | -6.6 | -13.3 | 1.7e-40 | -0.78 | 0.18 | 0.75 | FALSE |
21 | GTEx | Colon Transverse | CSE1L | 0.17 | 0.01 | enet | 19 | 0.03 | 1.2e-02 | 6.8 | -11.0 | 3.1e-28 | -0.49 | 0.18 | 0.20 | FALSE |
22 | GTEx | Esophagus Gastroesophageal Junction | CSE1L | 0.17 | 0.07 | lasso | 5 | 0.07 | 1.6e-03 | -6.5 | -9.7 | 4.3e-22 | -0.49 | 0.30 | 0.25 | TRUE |
23 | GTEx | Esophagus Mucosa | ATP9A | 0.15 | 0.05 | lasso | 5 | 0.01 | 6.6e-02 | -5.4 | -5.3 | 1.2e-07 | 0.07 | 0.16 | 0.41 | TRUE |
24 | GTEx | Esophagus Mucosa | CSE1L | 0.09 | 0.06 | lasso | 4 | 0.06 | 6.9e-05 | 16.6 | -15.7 | 1.6e-55 | -0.80 | 0.19 | 0.76 | FALSE |
25 | GTEx | Esophagus Mucosa | ZFAS1 | 0.15 | 0.01 | enet | 16 | 0.01 | 8.9e-02 | 18.6 | 12.6 | 1.3e-36 | 0.69 | 0.03 | 0.89 | FALSE |
26 | GTEx | Esophagus Muscularis | CSE1L | 0.16 | 0.14 | enet | 22 | 0.12 | 5.1e-08 | -6.6 | -8.1 | 3.8e-16 | -0.44 | 0.96 | 0.03 | FALSE |
27 | GTEx | Heart Atrial Appendage | CSE1L | 0.09 | 0.07 | lasso | 5 | 0.06 | 9.1e-04 | -6.6 | -6.1 | 1.0e-09 | -0.42 | 0.55 | 0.09 | FALSE |
28 | GTEx | Lung | CSE1L | 0.10 | 0.09 | lasso | 5 | 0.08 | 6.6e-07 | 14.8 | -14.5 | 1.5e-47 | -0.73 | 0.63 | 0.36 | FALSE |
29 | GTEx | Muscle Skeletal | PREX1 | 0.14 | 0.09 | enet | 23 | 0.13 | 2.5e-12 | 13.8 | 12.0 | 4.0e-33 | 0.51 | 0.83 | 0.17 | FALSE |
30 | GTEx | Muscle Skeletal | CSE1L | 0.18 | 0.19 | lasso | 9 | 0.20 | 4.6e-19 | -6.6 | -5.7 | 1.1e-08 | -0.42 | 1.00 | 0.00 | FALSE |
31 | GTEx | Nerve Tibial | CSE1L | 0.12 | 0.01 | lasso | 10 | 0.03 | 5.7e-03 | -6.6 | -8.2 | 1.7e-16 | -0.48 | 0.19 | 0.22 | FALSE |
32 | GTEx | Skin Not Sun Exposed Suprapubic | ZFAS1 | 0.16 | 0.04 | enet | 19 | 0.07 | 1.0e-04 | 12.1 | 10.7 | 6.1e-27 | 0.69 | 0.05 | 0.90 | FALSE |
33 | GTEx | Skin Sun Exposed Lower leg | CSE1L | 0.08 | 0.03 | lasso | 2 | 0.03 | 9.5e-04 | 16.9 | -16.2 | 6.9e-59 | -0.81 | 0.47 | 0.16 | FALSE |
34 | GTEx | Skin Sun Exposed Lower leg | ZFAS1 | 0.07 | 0.03 | enet | 14 | 0.05 | 5.8e-05 | 18.6 | 13.9 | 8.2e-44 | 0.77 | 0.03 | 0.96 | FALSE |
35 | GTEx | Testis | ARFGEF2 | 0.20 | 0.20 | lasso | 7 | 0.24 | 5.4e-11 | 14.7 | -17.3 | 7.7e-67 | -0.91 | 0.02 | 0.98 | FALSE |
36 | GTEx | Testis | RP4-530I15.9 | 0.36 | 0.42 | lasso | 1 | 0.42 | 3.3e-20 | 6.0 | 6.0 | 1.7e-09 | -0.07 | 1.00 | 0.00 | FALSE |
37 | GTEx | Thyroid | CSE1L | 0.20 | 0.21 | enet | 15 | 0.20 | 2.3e-15 | -7.2 | -6.9 | 4.4e-12 | -0.44 | 1.00 | 0.00 | FALSE |
38 | GTEx | Thyroid | SLC9A8 | 0.14 | 0.03 | enet | 16 | 0.02 | 2.3e-02 | 2.7 | 6.1 | 1.2e-09 | -0.09 | 0.14 | 0.08 | FALSE |
39 | GTEx | Whole Blood | ZFAS1 | 0.07 | 0.06 | lasso | 4 | 0.05 | 1.3e-05 | -9.9 | -9.9 | 4.8e-23 | -0.20 | 1.00 | 0.00 | TRUE |
40 | METSIM | Adipose | ARFGEF2 | 0.04 | 0.03 | lasso | 12 | 0.02 | 9.8e-05 | 18.8 | -19.0 | 7.4e-81 | -0.98 | 0.02 | 0.98 | TRUE |
41 | METSIM | Adipose | CSE1L | 0.05 | 0.05 | lasso | 4 | 0.04 | 5.3e-07 | -6.5 | -9.4 | 4.9e-21 | -0.58 | 0.91 | 0.09 | FALSE |
42 | METSIM | Adipose | PARD6B | 0.03 | 0.00 | bslmm | 494 | 0.01 | 5.1e-02 | 3.4 | -6.7 | 1.9e-11 | 0.02 | 0.05 | 0.20 | TRUE |
43 | METSIM | Adipose | RP11-290F20.1 | 0.10 | 0.08 | lasso | 3 | 0.08 | 4.9e-12 | 6.2 | 7.6 | 2.4e-14 | -0.08 | 1.00 | 0.00 | TRUE |
44 | METSIM | Adipose | SLC9A8 | 0.07 | 0.01 | lasso | 6 | 0.01 | 3.1e-03 | -3.6 | 5.4 | 5.6e-08 | -0.07 | 0.55 | 0.03 | TRUE |
45 | NTR | Blood | NCRNA00275 | 0.07 | 0.06 | lasso | 4 | 0.08 | 9.7e-25 | -9.7 | -15.4 | 3.0e-53 | -0.53 | 1.00 | 0.00 | TRUE |
46 | NTR | Blood | SNORD12B | 0.03 | 0.05 | lasso | 8 | 0.05 | 1.9e-14 | 18.6 | -19.0 | 7.4e-81 | -0.96 | 0.02 | 0.98 | FALSE |
47 | ROSMAP | Brain Pre-frontal Cortex | CSE1L | 0.04 | 0.02 | enet | 16 | 0.02 | 2.8e-03 | 13.7 | -14.4 | 8.9e-47 | -0.72 | 0.10 | 0.89 | FALSE |
48 | ROSMAP | Brain Pre-frontal Cortex | SLC9A8 | 0.14 | 0.04 | enet | 10 | 0.14 | 2.0e-17 | 2.7 | 7.5 | 7.3e-14 | -0.01 | 1.00 | 0.00 | FALSE |
49 | YFS | Blood | CSE1L | 0.06 | 0.05 | enet | 21 | 0.06 | 2.0e-19 | -6.6 | -12.4 | 1.9e-35 | -0.60 | 1.00 | 0.00 | FALSE |
50 | YFS | Blood | PTPN1 | 0.37 | 0.30 | enet | 21 | 0.30 | 1.1e-101 | 8.7 | -9.7 | 2.2e-22 | 0.00 | 0.98 | 0.02 | FALSE |
51 | YFS | Blood | RNF114 | 0.08 | 0.04 | bslmm | 442 | 0.04 | 4.0e-12 | 4.3 | 6.6 | 5.1e-11 | -0.02 | 1.00 | 0.00 | TRUE |
52 | YFS | Blood | ZNFX1 | 0.06 | 0.05 | lasso | 3 | 0.05 | 1.4e-16 | 8.5 | -10.8 | 2.1e-27 | -0.55 | 1.00 | 0.00 | FALSE |
53 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STAU1 | 0.01 | 0.01 | blup | 54 | 0.01 | 6.1e-03 | -10.1 | -11.4 | 4.4e-30 | -0.46 | 0.03 | 0.13 | FALSE |
54 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNAI1 | 0.09 | 0.10 | lasso | 5 | 0.06 | 3.1e-04 | -10.4 | 10.4 | 2.8e-25 | -0.03 | 0.19 | 0.59 | TRUE |
55 | The Cancer Genome Atlas | Glioblastoma Multiforme | CSE1L | 0.15 | 0.06 | lasso | 3 | 0.07 | 4.4e-03 | -6.3 | -5.9 | 4.0e-09 | -0.37 | 0.03 | 0.08 | FALSE |
56 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CSE1L | 0.03 | 0.05 | lasso | 1 | 0.03 | 9.3e-05 | 14.7 | -14.7 | 4.1e-49 | -0.75 | 0.27 | 0.65 | FALSE |
57 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CSE1L | 0.05 | 0.07 | blup | 50 | 0.07 | 3.2e-08 | 15.7 | -15.7 | 1.4e-55 | -0.80 | 0.44 | 0.56 | FALSE |
58 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC9A8 | 0.10 | 0.07 | lasso | 5 | 0.08 | 1.6e-09 | -3.6 | 5.2 | 2.4e-07 | -0.04 | 0.45 | 0.55 | FALSE |
59 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARFGEF2 | 0.05 | 0.04 | lasso | 5 | 0.05 | 3.2e-06 | 18.0 | -18.3 | 1.4e-74 | -0.94 | 0.00 | 1.00 | FALSE |
60 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CSE1L | 0.05 | 0.06 | lasso | 3 | 0.05 | 1.0e-06 | -6.3 | -7.0 | 2.6e-12 | -0.47 | 0.94 | 0.05 | FALSE |
61 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC9A8 | 0.07 | 0.02 | blup | 82 | 0.02 | 8.6e-04 | -10.1 | 8.2 | 1.9e-16 | -0.01 | 0.00 | 0.99 | FALSE |
62 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C20orf199 | 0.04 | 0.00 | enet | 8 | 0.02 | 6.4e-03 | 8.5 | 12.8 | 8.8e-38 | 0.62 | 0.01 | 0.50 | FALSE |
63 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C20orf199 | 0.05 | 0.06 | lasso | 4 | 0.06 | 1.0e-04 | 18.6 | 18.6 | 2.2e-77 | 0.92 | 0.00 | 0.96 | FALSE |
64 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CSE1L | 0.05 | 0.05 | lasso | 3 | 0.06 | 8.1e-07 | -7.2 | -6.8 | 7.8e-12 | -0.44 | 0.94 | 0.02 | FALSE |
65 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CSE1L | 0.13 | 0.03 | blup | 50 | 0.07 | 1.4e-03 | 14.7 | -13.5 | 2.4e-41 | -0.60 | 0.03 | 0.27 | FALSE |
66 | The Cancer Genome Atlas | Thyroid Carcinoma | ARFGEF2 | 0.06 | 0.01 | blup | 79 | 0.03 | 4.2e-04 | -7.8 | -10.5 | 1.2e-25 | -0.42 | 0.75 | 0.05 | FALSE |
67 | The Cancer Genome Atlas | Thyroid Carcinoma | CSE1L | 0.12 | 0.20 | lasso | 2 | 0.19 | 7.1e-18 | -6.6 | -6.6 | 5.4e-11 | -0.43 | 1.00 | 0.00 | FALSE |
68 | The Cancer Genome Atlas | Thyroid Carcinoma | DDX27 | 0.08 | 0.05 | lasso | 3 | 0.05 | 1.9e-05 | 18.6 | 16.5 | 2.3e-61 | 0.85 | 0.02 | 0.96 | FALSE |
69 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC9A8 | 0.21 | 0.12 | blup | 83 | 0.13 | 5.7e-13 | -3.7 | 6.9 | 6.4e-12 | -0.03 | 0.54 | 0.46 | FALSE |