Best TWAS P=5.86e-30 · Best GWAS P=6.32e-47 conditioned to 5.3e-34
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC30A6 | 0.04 | 0.01 | blup | 294 | 0.02 | 2.7e-03 | -5.1 | 5.3 | 1.2e-07 | 0.04 | 0.32 | 0.03 | FALSE |
| 2 | GTEx | Adrenal Gland | TTC27 | 0.17 | 0.00 | enet | 23 | 0.05 | 6.9e-03 | -2.1 | 10.1 | 4.5e-24 | -0.07 | 0.08 | 0.18 | TRUE |
| 3 | GTEx | Artery Tibial | LTBP1 | 0.10 | 0.04 | enet | 12 | 0.03 | 1.5e-03 | -9.3 | 10.2 | 1.6e-24 | -0.11 | 0.80 | 0.05 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | SPAST | 0.18 | 0.04 | lasso | 3 | 0.08 | 1.3e-03 | 7.2 | -7.2 | 8.5e-13 | 0.01 | 0.02 | 0.57 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | RP11-563N4.1 | 0.16 | 0.00 | enet | 17 | 0.01 | 1.4e-01 | -5.6 | 6.3 | 2.8e-10 | 0.02 | 0.08 | 0.21 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | SPAST | 0.06 | 0.01 | lasso | 3 | 0.01 | 8.7e-02 | -5.3 | -5.2 | 1.6e-07 | -0.02 | 0.19 | 0.12 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | LTBP1 | 0.48 | 0.51 | enet | 58 | 0.51 | 2.4e-43 | -10.6 | 11.4 | 5.9e-30 | -0.07 | 1.00 | 0.00 | TRUE |
| 8 | GTEx | Thyroid | SPAST | 0.08 | 0.02 | lasso | 3 | 0.01 | 1.0e-01 | -5.7 | -5.5 | 3.5e-08 | 0.04 | 0.18 | 0.12 | FALSE |
| 9 | METSIM | Adipose | DPY30 | 0.02 | 0.00 | bslmm | 325 | 0.00 | 2.8e-01 | 5.1 | 6.1 | 1.1e-09 | -0.01 | 0.10 | 0.05 | FALSE |
| 10 | METSIM | Adipose | YIPF4 | 0.05 | 0.01 | bslmm | 323 | 0.01 | 3.0e-03 | 6.5 | 7.0 | 1.9e-12 | 0.03 | 0.03 | 0.68 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | SLC30A6 | 0.02 | 0.00 | blup | 288 | 0.01 | 7.7e-03 | 6.5 | 7.3 | 2.5e-13 | 0.00 | 0.08 | 0.50 | TRUE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | DPY30 | 0.03 | 0.02 | bslmm | 268 | 0.01 | 7.4e-03 | 6.6 | 7.0 | 2.3e-12 | 0.01 | 0.10 | 0.36 | FALSE |
| 13 | YFS | Blood | BIRC6 | 0.02 | 0.00 | blup | 458 | 0.00 | 3.0e-02 | -7.2 | 5.6 | 2.7e-08 | -0.04 | 0.13 | 0.08 | FALSE |
| 14 | The Cancer Genome Atlas | Glioblastoma Multiforme | DPY30 | 0.21 | 0.04 | blup | 27 | 0.07 | 4.3e-03 | 2.6 | 5.5 | 3.8e-08 | 0.01 | 0.01 | 0.05 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FAM98A | 0.09 | 0.03 | blup | 56 | 0.02 | 2.0e-02 | 3.7 | 6.6 | 3.4e-11 | -0.04 | 0.03 | 0.67 | TRUE |
| 16 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | LTBP1 | 0.21 | 0.08 | lasso | 5 | 0.08 | 1.8e-04 | 3.2 | -8.6 | 6.8e-18 | 0.07 | 0.13 | 0.22 | TRUE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NLRC4 | 0.02 | 0.03 | lasso | 3 | 0.02 | 1.9e-03 | -6.0 | 6.0 | 2.0e-09 | 0.00 | 0.09 | 0.52 | TRUE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SRD5A2 | 0.05 | 0.03 | enet | 6 | 0.04 | 4.4e-05 | 6.3 | -7.2 | 4.4e-13 | 0.03 | 0.04 | 0.93 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | MEMO1 | 0.04 | 0.00 | blup | 78 | 0.01 | 2.3e-02 | 6.6 | 6.8 | 1.3e-11 | -0.04 | 0.03 | 0.27 | FALSE |