Hub : Genes

MEMO1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.254 0.094 0.00055 0.001 NA 0.017 NA 0.009 0.28 NA 0.036 NA 0.1
2 TCGA Thyroid Carcinoma 0.037 0.026 0.00780 0.005 0.012 0.008 NA 0.002 0.10 0.023 0.047 NA 0.2

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.6 2.5 2.5 1.6 -1.6
Bipolar Disorder or Schizophrenia 1.9 4.8 5.9 1.9 -2.4
Depressed Affect (Nagel 2018) 2.9 6.2 7.9 2.1 -2.8
Depression (Nagel 2018) 0.7 1.1 2.2 0.3 -1.5
Intelligence (Savage-Jansen 2018) 0.3 1.1 1.5 -1.2 0.8
Neuroticism (Nagel 2018) 1.7 4.1 5.4 1.7 -2.3
Schizophrenia (2018) 1.3 2.8 3.4 1.5 -1.8
Schizophrenia vs Biploar Disorder 0.5 0.7 1.2 1.1 -0.4
Worry (Nagel 2018) 0.4 0.8 1.3 0.5 -1.1
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 0.1 -0.7
Alzheimer’s Disease (in father) 1.4 1.5 2.0 -1.0 1.4
Alzheimer’s Disease (including proxy) 0.0 0.1 0.1 -0.3 0.0
Crohns Disease (2017) 0.1 0.2 0.3 0.4 0.6
Irritable Bowel Disease (IBD) 0.2 0.4 0.7 -0.3 0.9
Ulcerative Colitis (UC) 0.1 0.2 0.3 -0.2 0.6
Major Depression (MDD) 0.6 0.7 0.8 0.9 -0.8
Reaction Time 2.3 4.4 8.7 -0.0 -2.9
Verbal and Numeric Reasoning (VNR) 0.7 1.6 2.0 -1.4 1.1
Breast Cancer 1.7 4.0 4.3 -1.9 2.1
Ovarian Cancer 0.2 0.3 0.3 -0.5 0.5
Prostate Cancer 0.7 1.0 2.0 0.2 -1.4
Age at First Birth 4.4 6.4 6.6 -2.5 2.6
Bipolar Disorder (2011) 4.3 4.1 5.5 1.7 -2.3
Body Mass Index (BMI) (2010) 0.5 0.7 1.3 0.2 -1.2
Coronary Artery Disease (CAD) 2.8 3.3 4.7 2.2 -1.4
Crohns Disease (2012) 0.1 0.1 0.2 0.5 0.2
Mean Putamen Volume 1.0 1.1 1.3 -1.0 1.1
Fasting Glucose 1.1 1.3 1.4 1.2 -1.1
HbA1C 0.4 0.5 0.7 -0.8 -0.5
HDL Cholesterol 0.4 0.7 1.2 0.3 1.1
LDL Cholesterol 0.5 0.9 1.7 -0.2 -1.3
Lupus 1.1 1.7 2.8 0.8 -1.7
Neuroticism (2016) 2.4 3.5 5.2 1.3 -2.3
Primary Biliary Cirrhosis 0.6 0.8 0.9 0.9 -1.0
Rheumatoid Arthritis 1.4 1.9 2.9 -0.9 1.7
Schizophrenia (2014) 2.8 6.3 6.6 2.4 -2.6
Triglycerides 0.3 0.5 0.8 -0.3 -0.9
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 -0.1 -0.5
Ulcerative Colitis 0.8 1.2 2.3 1.5 -0.1
Blood Eosinophil Count 0.4 3.3 6.2 -0.7 2.5
Blood Platelet Count 0.2 1.8 2.3 1.1 -1.5
Blood Red Count 0.0 0.0 0.0 -0.1 0.2
Blood White Count 0.0 0.2 0.3 0.4 -0.5
Heel T-Score 0.7 5.5 10.7 0.6 -3.3
BMI 0.1 0.5 0.6 -0.6 -0.8
Height 1.4 26.6 45.7 -2.7 6.8
Waist Hip Ratio (WHR) 0.9 4.1 5.5 1.6 -2.4
Systolic Blood Pressure 0.4 1.9 3.1 0.9 -1.8
Smoking Status 1.4 3.3 5.6 1.1 -2.4
Allergy or Eczema 0.3 0.7 1.3 -0.3 -1.1
Cardiovascular Disease 1.2 3.9 5.0 1.7 -2.2
Hypothyroidism (self reported) 0.3 0.7 1.2 1.1 0.5
Respiratory disease 1.0 2.3 4.0 2.0 -0.8
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.5 0.7 -0.6
Lung FEV1/FVC ratio 0.3 1.3 1.6 -1.3 1.0
Lung FVC 0.5 2.6 3.2 1.8 -1.4
Neuroticism 1.9 4.6 5.7 1.9 -2.4
Chronotype (morning person) 1.5 3.4 6.5 -0.6 2.5
Hair Pigment 0.0 0.8 1.3 0.4 1.2
Tanning 0.3 3.7 6.3 1.1 -2.5
Hand grip strength (left) 0.1 0.3 0.4 0.7 -0.3
Number of treatments/medications taken 1.7 3.1 3.7 1.6 -1.9
Average weekly spirits intake 2.7 3.4 3.5 -1.9 1.8
Sensitivity / hurt feelings 2.2 3.7 6.0 2.5 -1.2
Frequency of depressed mood in last 2 weeks 1.1 1.5 2.6 0.7 -1.6
Hearing difficulty/problems: Yes 0.3 0.5 0.7 0.5 -0.8
Relative age of first facial hair 1.2 2.6 3.8 -1.2 2.0
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 1.4 1.0 -1.2
Ever used hormone-replacement therapy (HRT) 1.9 2.4 4.5 0.6 -2.1
Ever had hysterectomy (womb removed) 0.8 0.9 1.6 -1.3 -0.5
Systolic blood pressure, automated reading 0.3 0.9 1.8 0.3 -1.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.9 0.1 -0.9
Angina 2.3 3.0 5.8 0.4 -2.4
Medication for hormone replacement therapy 0.1 0.1 0.2 0.2 -0.4
Vitamin and mineral supplements 0.2 0.3 0.6 0.7 -0.1
Supplements: Zinc 0.5 0.6 1.1 0.3 -1.1
Medication: Co-codamol 0.8 0.9 1.2 1.1 -0.8
Medication: Metformin 0.2 0.3 0.5 -0.7 -0.3
Diabetes (father) 0.5 0.6 0.9 -0.5 -0.9
Diabetes (mother) 1.0 1.3 2.3 -0.5 1.5
Severe depression (siblings) 0.7 0.8 1.6 -0.0 -1.3
Pack years adult smoking proportion 0.5 0.8 1.6 -0.0 -1.2
Impedance of leg (right) 0.1 0.3 0.4 -0.7 0.3
Leg fat-free mass (left) 0.2 1.0 1.5 -0.6 1.2
Trunk fat percentage 0.6 2.2 4.2 -0.5 -2.0
Hand grip strength (right) 0.1 0.2 0.2 0.5 0.2
Townsend deprivation index at recruitment 3.5 4.8 7.0 1.6 -2.6
Current tobacco smoking 1.1 1.9 3.6 0.4 -1.9
Average weekly fortified wine intake 1.5 1.8 2.9 -1.7 0.8
Maternal smoking around birth 0.1 0.1 0.2 -0.1 -0.4
Fed-up feelings 3.1 5.6 7.7 1.9 -2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 5.3 0.6 -2.3
Relative age voice broke 0.5 0.8 1.5 -1.2 0.4
Taking other prescription medications 1.7 2.6 2.9 1.5 -1.7
Age when periods started (menarche) 0.6 1.4 2.8 -0.2 1.7
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.6 -1.3 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.1 0.2 0.4
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.0 -1.4 0.7
Qualifications: CSEs or equivalent 0.2 0.2 0.3 0.6 0.3
Serious illness, injury or assault to yourself 0.7 0.9 1.7 1.3 0.3
High blood pressure 0.7 1.9 2.8 1.0 -1.7
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.2 -1.1 -0.3
Multivitamins +/- minerals 0.5 0.7 1.0 -1.0 -0.6
Stomach or abdominal pain in last month 0.0 0.0 0.0 -0.1 0.2
Supplements: Glucosamine 2.4 3.1 5.1 1.0 -2.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.0 -0.5 -1.0
Medication: Atenolol 0.5 0.7 0.8 0.9 -0.8
Medication: Levothyroxine sodium 0.3 0.4 0.5 0.7 0.6
Sitting height 2.0 14.0 24.1 -2.0 4.9
Chronic bronchitis/emphysema (father) 1.2 1.4 2.7 0.3 -1.6
High blood pressure (mother) 0.8 1.1 1.8 0.7 -1.4
Body mass index (BMI) 0.3 1.1 1.9 -0.6 -1.4
Impedance of leg (left) 0.1 0.3 0.3 -0.5 -0.5
Leg predicted mass (left) 0.2 0.8 1.4 -0.5 1.2
Trunk fat mass 0.2 1.0 1.7 -0.6 -1.3
Waist circumference 0.4 1.4 2.8 0.1 -1.7
Number of incorrect matches in round 1.2 2.0 2.7 1.2 -1.6
Past tobacco smoking 0.9 1.6 2.3 -0.9 1.5
Alcohol usually taken with meals 0.4 0.7 1.3 0.0 1.2
Nervous feelings 0.1 0.2 0.3 0.2 0.6
Frequency of tenseness / restlessness in last 2 weeks 1.9 2.9 4.6 1.1 -2.1
Hearing difficulty/problems with background noise 0.3 0.5 0.9 0.3 -1.0
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 -0.3 0.1
Had menopause 0.6 0.7 1.2 -0.5 -1.1
Had other major operations 0.4 0.5 0.9 0.3 -0.9
Forced vital capacity (FVC) 0.1 0.6 0.8 0.6 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.2 -0.4 0.4
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 4.6 0.2 -2.1
Qualifications: None of the above 0.5 1.1 2.1 -0.2 -1.4
Financial difficulties in last 2 years 0.3 0.5 0.5 0.7 -0.7
Mouth/teeth dental problems 1.0 1.6 3.2 0.1 1.8
Heart attack 1.3 1.6 3.2 0.3 -1.8
Allergy 0.1 0.2 0.3 0.3 0.5
Pain all over the body in last month 0.7 0.7 0.8 0.9 -0.9
Diabetes (self-reported) 0.1 0.2 0.2 -0.4 0.4
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.0 0.1 0.2
Medication: Ramipril 1.1 1.4 2.7 0.2 -1.6
Medication: Simvastatin 2.3 3.4 5.9 0.9 -2.4
Fluid intelligence score 1.1 2.4 2.9 -1.7 1.4
Illnesses of siblings 1.0 1.4 2.1 1.4 0.8
Neuroticism score 2.4 4.9 5.0 2.2 -2.2
Weight 0.1 0.5 0.9 -0.9 -0.1
Impedance of arm (right) 0.0 0.2 0.3 0.1 -0.6
Arm fat percentage (right) 0.6 2.2 4.4 -0.3 -2.1
Trunk fat-free mass 0.5 2.7 3.8 -1.2 1.9
Hip circumference 0.0 0.1 0.2 -0.2 -0.4
Time employed in main current job 1.2 1.4 1.5 -1.1 1.2
Alcohol intake versus 10 years previously 0.9 1.3 2.3 -1.5 -0.6
Father’s age at death 0.0 0.0 0.1 -0.1 0.3
Worrier / anxious feelings 0.2 0.3 0.5 0.4 -0.7
Frequency of tiredness / lethargy in last 2 weeks 2.5 4.0 8.1 -0.1 -2.8
Falls in the last year 0.4 0.6 1.1 -0.3 -1.0
Hair/balding pattern: Pattern 3 5.5 8.2 16.1 0.5 -4.0
Number of live births 0.3 0.4 0.7 0.4 -0.8
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.2 -0.1 1.5
Pulse rate 0.8 1.4 1.8 1.3 1.0
Happiness 3.1 3.8 7.5 -0.3 -2.7
Noisy workplace 2.3 2.9 3.4 1.9 -1.5
Qualifications: A levels/AS levels or equivalent 0.5 1.1 1.6 0.9 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.2 0.4 0.4
Mouth/teeth dental problems: Dentures 0.8 1.4 2.8 0.2 -1.7
Asthma 2.7 5.2 7.1 2.7 -1.8
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.8 -1.4 -0.1
Medication: Cholesterol lowering 1.2 1.9 2.2 1.3 -1.5
Depression (self-reported) 0.1 0.1 0.1 -0.4 -0.0
Medication: Lansoprazole 1.4 1.6 2.6 -0.7 1.6
Prospective memory result 1.1 1.3 1.5 -1.2 1.0
Lung cancer (father) 3.8 4.4 6.4 -2.5 1.6
Illnesses of mother 0.1 0.1 0.2 -0.0 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 2.2 0.0 1.5
Pulse wave Arterial Stiffness index 1.4 1.7 2.2 -1.5 1.1
Impedance of arm (left) 0.1 0.3 0.4 0.5 -0.7
Arm fat mass (right) 0.3 1.2 1.4 -1.0 -1.2
Trunk predicted mass 0.4 2.5 3.5 -1.2 1.9
Standing height 0.4 4.4 7.4 -1.2 2.7
Length of working week for main job 0.1 0.1 0.1 -0.3 0.1
Exposure to tobacco smoke at home 0.8 1.0 1.4 -1.2 0.7
Breastfed as a baby 0.1 0.1 0.3 -0.0 -0.5
Tense / ‘highly strung’ 1.2 2.0 3.0 1.0 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.3 4.7 2.2 -2.0
Hair/balding pattern: Pattern 4 6.3 15.2 19.8 3.2 -4.4
Birth weight of first child 0.3 0.6 1.2 -1.1 0.3
Peak expiratory flow (PEF) 2.3 5.3 9.6 -1.0 3.1
Pulse wave reflection index 3.2 3.9 5.2 -2.3 1.6
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.5 -1.2 -0.4
Loud music exposure frequency 1.9 2.1 2.7 -1.6 -1.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 0.5 0.5 -0.7
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.0 0.2 -0.0
Blood clot in the leg (DVT) 0.5 0.6 1.3 -1.1 0.0
Medication: Paracetamol 0.5 0.9 1.0 0.9 -1.0
Headache pain in last month 0.2 0.3 0.5 0.4 -0.7
Medication for cholesterol, blood pressure or diabetes 2.3 3.8 3.9 -1.9 2.0
Glaucoma (self-reported) 0.1 0.2 0.3 0.6 -0.1
Gout (self-reported) 3.8 5.2 5.3 2.3 -2.3
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.4 1.6 -0.3
Medication: Amlodipine 0.2 0.3 0.6 0.8 -0.3
Medication: Ventolin 100micrograms inhaler 1.2 1.5 3.0 1.7 0.1
Birth weight 1.9 4.2 4.3 -2.1 2.0
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.3 -0.6 -0.6
High blood pressure (siblings) 0.6 0.9 1.6 -1.3 0.3
Forced vital capacity (FVC), Best measure 0.3 1.1 2.2 0.0 1.5
Body fat percentage 0.6 2.3 4.2 -0.6 -2.0
Leg fat percentage (right) 0.4 1.3 2.4 -0.5 -1.6
Arm fat-free mass (right) 0.3 1.5 1.6 -1.2 1.3
Exposure to tobacco smoke outside home 0.9 1.1 1.9 -0.6 1.4
Comparative body size at age 10 0.6 1.7 3.4 -0.1 -1.8
Number of full brothers 1.4 1.7 2.0 1.2 -1.4
Worry too long after embarrassment 0.2 0.3 0.5 0.1 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 1.1 0.6 -1.0
Wheeze or whistling in the chest in last year 1.1 2.0 3.3 0.8 -1.8
Number of children fathered 0.3 0.4 0.5 -0.5 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.8 0.4 0.9
Age at first live birth 1.3 2.4 3.0 -1.7 1.3
Pulse wave peak to peak time 1.4 1.6 1.9 1.4 -1.2
Health satisfaction 4.0 5.2 8.8 1.3 -3.0
Shortness of breath walking on level ground 0.2 0.2 0.3 -0.3 0.6
Qualifications: College or University degree 0.1 0.3 0.3 0.6 -0.5
Eye problems/disorders: None of the above 0.4 0.5 0.9 -0.3 0.9
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.5 0.1 1.6
Emphysema/chronic bronchitis 0.1 0.1 0.3 -0.1 -0.5
Medication for pain relief, constipation, heartburn 0.7 1.2 1.7 0.8 1.3
Neck or shoulder pain in last month 0.3 0.4 0.4 0.7 -0.6
Medication: Blood pressure 2.2 3.9 4.8 1.7 -2.2
Angina (self-reported) 2.4 3.2 6.2 0.4 -2.5
Migraine (self-reported) 0.5 0.6 1.1 1.1 -0.3
Medication: Ibuprofen 0.3 0.3 0.6 -0.8 -0.2
Medication: Allopurinol 4.2 5.6 7.1 2.0 -2.7
Medication: Omeprazole 2.1 2.5 4.7 -0.6 -2.2
Medication: Seretide 50 evohaler 1.0 1.1 2.2 1.5 -0.2
Mean time to correctly identify matches 3.0 5.8 11.0 0.7 -3.3
Heart disease (mother) 0.4 0.5 0.9 -0.4 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.5 0.7 0.1
Whole body fat mass 0.3 1.1 1.2 -1.0 -1.1
Leg fat mass (right) 0.2 0.7 0.8 -0.7 -0.9
Arm predicted mass (right) 0.3 1.4 1.5 -1.1 1.2
Pulse rate, automated reading 0.2 0.7 1.3 1.1 0.2
Alcohol intake frequency. 0.7 1.7 3.3 -0.3 -1.8
Comparative height size at age 10 0.0 0.0 0.0 0.0 -0.1
Number of full sisters 0.5 0.6 1.2 1.1 -0.3
Suffer from ‘nerves’ 0.0 0.1 0.1 -0.1 -0.4
Overall health rating 3.6 7.7 15.3 0.5 -3.9
Chest pain or discomfort 1.5 2.2 3.9 0.7 -2.0
Had major operations 0.3 0.3 0.5 -0.7 -0.3
Age at last live birth 0.1 0.2 0.2 -0.5 0.3
Family relationship satisfaction 0.9 1.1 1.9 -1.4 -0.6
Leg pain on walking 1.0 1.3 1.9 -0.8 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.6 1.3 -0.5
Commuting to job workplace: Car/motor vehicle 1.0 1.1 1.9 1.4 -0.6
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.3 -1.5 0.3
Medication: Aspirin 1.4 1.8 3.6 0.2 -1.9
Supplements: Vitamin C 0.0 0.0 0.1 0.2 -0.3
Knee pain experienced in last month 0.8 1.2 2.4 -0.0 -1.6
Hypertension (Self-reported) 0.5 1.3 2.4 0.4 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 -0.4 -1.1
Illnesses of father: Heart disease 2.8 3.9 5.7 1.5 -2.4
Illnesses of siblings: Diabetes 1.1 1.3 2.4 -0.4 -1.6
Smoking status: Previous 0.5 0.8 1.1 0.7 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.7 1.3 -0.8
Whole body fat-free mass 0.3 1.9 2.6 -1.1 1.6
Leg fat-free mass (right) 0.1 0.6 0.9 -0.6 0.9
Arm fat percentage (left) 0.5 2.0 3.9 -0.3 -2.0
Average weekly red wine intake 1.0 1.5 2.4 1.6 -0.7
Handedness (chirality/laterality): Left-handed 1.9 2.3 4.1 -2.0 0.7
Mood swings 2.2 4.0 6.5 1.2 -2.5
Loneliness, isolation 2.4 3.3 4.9 1.3 -2.2
Long-standing illness, disability or infirmity 1.9 2.8 5.7 0.0 -2.4
Ever had bowel cancer screening 3.0 3.6 4.3 2.1 -1.7
Diabetes diagnosed by doctor 0.1 0.2 0.2 0.5 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 6.2 6.6 7.2 2.7 -2.5
Friendships satisfaction 1.2 1.5 2.2 -0.9 -1.5
Qualifications: nursing, teaching 0.3 0.5 0.7 0.5 -0.9
Commuting to job workplace: Walk 0.4 0.4 0.4 -0.6 -0.6
Eye problems/disorders: Cataract 0.9 1.1 2.2 -1.5 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 2.4 1.1 -1.6
Medication for cholesterol 0.0 0.0 0.0 0.2 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.4 -0.7 0.5
Back pain experienced in last month 0.4 0.7 1.3 -1.1 0.0
Mineral and other dietary supplements 2.0 2.6 4.7 -0.8 2.2
Breast cancer (self-reported) 0.6 0.7 1.1 -0.5 1.1
Asthma (self-reported) 2.5 5.0 6.7 2.6 -1.8
Osteoporosis (self-reported) 1.1 1.3 2.6 -0.3 -1.6
Osteoarthritis (self-reported) 0.6 0.8 1.2 -0.6 -1.1
Medication: Aspirin 1.9 2.5 4.5 0.7 -2.1
Medication: Gliclazide 0.1 0.1 0.3 -0.1 -0.5
Illnesses of father: None of the above (group 1) 0.9 1.1 2.2 -0.2 1.5
Smoking status: Current 0.8 1.3 2.5 0.3 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.3 0.3 -1.1
Whole body water mass 0.3 1.6 2.2 -1.0 1.5
Leg predicted mass (right) 0.1 0.5 0.7 -0.6 0.8
Arm fat mass (left) 0.2 1.0 1.4 -0.8 -1.2
Number of self-reported non-cancer illnesses 4.1 7.2 10.4 2.0 -3.2
Average weekly champagne plus white wine intake 1.7 2.4 4.5 0.5 2.1
Miserableness 0.8 1.3 1.5 1.1 -1.2
Guilty feelings 1.2 1.9 3.3 0.7 -1.8
Wears glasses or contact lenses 0.1 0.1 0.1 -0.3 -0.3
Ever taken oral contraceptive pill 2.8 3.1 3.4 1.8 -1.7
Hearing aid user 0.2 0.3 0.3 -0.6 0.5
Mother’s age at death 0.4 0.5 0.5 0.7 0.7
Financial situation satisfaction 4.0 4.9 9.5 0.6 -3.1
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.1 0.1 0.3
Commuting to job workplace: Public transport 0.1 0.1 0.2 -0.2 0.4
Eye problems/disorders: Glaucoma 0.7 0.9 1.0 1.0 -0.9
Medication: Blood pressure 0.0 0.0 0.1 -0.2 0.0
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.4 -0.7 -0.6
Supplements: Fish oil (including cod liver oil) 1.6 2.1 3.9 0.4 -2.0
High cholesterol (Self-reported) 0.2 0.4 0.4 0.6 -0.6
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.1 0.5
Medication: Paracetamol 0.0 0.1 0.1 0.3 -0.1
Medication: Lisinopril 0.6 0.8 1.1 1.0 -0.7
Medication: Atorvastatin 0.2 0.2 0.3 -0.6 -0.4
Illnesses of father: High blood pressure 0.2 0.2 0.2 0.4 -0.5
Alcohol drinker status: Never 0.8 0.9 1.1 -1.0 0.9
Ever smoked 0.3 0.6 1.0 0.4 -1.0
Basal metabolic rate 0.2 1.3 1.4 -1.1 1.2
Leg fat percentage (left) 0.6 2.3 4.4 -0.4 -2.1
Arm fat-free mass (left) 0.3 1.4 1.8 -1.3 1.0
Number of operations (self-reported) 0.0 0.0 0.1 0.1 -0.3
Average weekly beer plus cider intake 1.1 1.6 2.6 -0.8 1.6
Irritability 6.5 11.0 13.2 3.0 -3.6
Risk taking 0.6 0.9 1.2 0.7 -1.1
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.7 0.8 -0.5
Fractured/broken bones in last 5 years 3.1 3.9 5.6 1.5 -2.4
Age started oral contraceptive pill 0.1 0.1 0.1 0.3 0.2
Diastolic blood pressure, automated reading 0.2 0.6 0.9 0.5 -0.9
Ever depressed for a whole week 0.2 0.3 0.4 0.3 -0.6
Unable to work because of sickness or disability 0.5 0.7 1.1 -1.1 0.4
Commuting to job workplace: Cycle 0.3 0.3 0.5 -0.3 0.7
Myopia 0.2 0.2 0.3 -0.4 0.6
Vascular/heart problems diagnosed by doctor 0.7 2.0 3.7 -0.6 1.9
Cholesterol lowering medication 0.3 0.4 0.8 -0.1 -0.9
Medication: Omeprazole (e.g. Zanprol) 2.1 2.5 5.1 -0.1 -2.3
Pain experienced in last month 0.7 1.2 2.3 0.1 1.5
Supplements: Calcium 1.3 1.4 1.9 0.9 -1.4
Basal cell carcinoma (self-reported) 0.7 0.8 0.8 -0.9 -0.8
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.8 0.2 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.0 -1.0 0.0
Heart disease (siblings) 0.0 0.1 0.1 -0.0 -0.3
Alcohol drinker status: Previous 1.3 1.5 1.8 1.3 -1.1
Pack years of smoking 0.5 0.7 1.4 -0.1 -1.2
Impedance of whole body 0.0 0.1 0.3 0.1 -0.5
Leg fat mass (left) 0.2 0.9 1.4 -0.7 -1.2
Arm predicted mass (left) 0.3 1.6 2.0 -1.4 1.1