Best TWAS P=5.72e-52 · Best GWAS P=1.81e-46 conditioned to 2.72e-43
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FEZ2 | 0.16 | 0.24 | lasso | 2 | 0.22 | 1.3e-26 | 12.73 | -12.7 | 4.8e-37 | 0.00 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | ATL2 | 0.13 | 0.02 | lasso | 5 | 0.04 | 2.2e-04 | 5.71 | 5.2 | 1.7e-07 | -0.04 | 0.48 | 0.04 | FALSE |
3 | GTEx | Adipose Subcutaneous | AC007401.1 | 0.10 | 0.02 | lasso | 4 | 0.02 | 5.4e-03 | 10.99 | 11.2 | 3.8e-29 | -0.04 | 0.48 | 0.03 | FALSE |
4 | GTEx | Artery Tibial | CYP1B1 | 0.16 | 0.06 | lasso | 5 | 0.07 | 3.8e-06 | 6.47 | 6.2 | 5.7e-10 | -0.07 | 0.64 | 0.02 | FALSE |
5 | GTEx | Artery Tibial | CRIM1 | 0.10 | 0.04 | lasso | 4 | 0.05 | 1.4e-04 | 10.99 | -13.4 | 5.5e-41 | 0.03 | 0.10 | 0.86 | FALSE |
6 | GTEx | Artery Tibial | RP11-78I14.1 | 0.10 | 0.08 | enet | 16 | 0.07 | 4.2e-06 | 10.99 | -13.3 | 1.6e-40 | 0.07 | 0.17 | 0.75 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | CRIM1 | 0.36 | 0.21 | lasso | 5 | 0.16 | 5.4e-05 | 9.68 | 10.6 | 2.1e-26 | -0.03 | 0.34 | 0.06 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | FEZ2 | 0.41 | 0.30 | lasso | 6 | 0.28 | 8.6e-08 | 10.73 | 10.7 | 8.6e-27 | -0.01 | 0.82 | 0.02 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | AC007401.1 | 0.40 | 0.26 | lasso | 4 | 0.22 | 2.3e-06 | 9.68 | 10.5 | 1.3e-25 | -0.02 | 0.73 | 0.02 | FALSE |
10 | GTEx | Brain Cerebellar Hemisphere | RP11-490M8.1 | 0.37 | 0.18 | lasso | 4 | 0.15 | 1.2e-04 | 10.91 | 11.4 | 6.5e-30 | -0.01 | 0.26 | 0.09 | FALSE |
11 | GTEx | Brain Cerebellum | FEZ2 | 0.44 | 0.26 | lasso | 6 | 0.23 | 2.6e-07 | 10.01 | 9.4 | 6.7e-21 | -0.01 | 0.93 | 0.02 | FALSE |
12 | GTEx | Brain Cerebellum | AC007401.1 | 0.27 | 0.21 | enet | 5 | 0.20 | 1.5e-06 | 9.68 | 10.1 | 6.7e-24 | -0.02 | 0.62 | 0.08 | FALSE |
13 | GTEx | Brain Cerebellum | RP11-490M8.1 | 0.21 | 0.21 | lasso | 4 | 0.20 | 1.4e-06 | 9.64 | 9.9 | 2.6e-23 | -0.03 | 0.58 | 0.06 | FALSE |
14 | GTEx | Heart Left Ventricle | CRIM1 | 0.20 | 0.11 | lasso | 6 | 0.15 | 3.1e-08 | -6.80 | 5.3 | 1.1e-07 | 0.02 | 0.88 | 0.00 | FALSE |
15 | GTEx | Heart Left Ventricle | RP11-490M8.1 | 0.28 | 0.11 | lasso | 6 | 0.14 | 3.7e-08 | -6.80 | 6.0 | 2.0e-09 | 0.05 | 0.99 | 0.00 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | RP11-78I14.1 | 0.14 | 0.06 | enet | 8 | 0.04 | 6.0e-04 | -13.01 | -11.8 | 5.7e-32 | -0.01 | 0.04 | 0.90 | FALSE |
17 | GTEx | Spleen | FEZ2 | 0.42 | 0.16 | enet | 25 | 0.17 | 3.9e-05 | 9.64 | 10.6 | 2.2e-26 | -0.02 | 0.28 | 0.23 | FALSE |
18 | GTEx | Whole Blood | FEZ2 | 0.11 | 0.09 | enet | 25 | 0.10 | 8.4e-10 | 10.73 | 7.3 | 4.0e-13 | -0.04 | 1.00 | 0.00 | FALSE |
19 | GTEx | Whole Blood | AC007401.1 | 0.06 | 0.06 | lasso | 5 | 0.05 | 4.6e-05 | 10.73 | 10.8 | 3.8e-27 | 0.00 | 0.78 | 0.01 | FALSE |
20 | METSIM | Adipose | STRN | 0.07 | 0.03 | blup | 624 | 0.03 | 8.3e-06 | -0.56 | 5.4 | 6.9e-08 | 0.05 | 0.94 | 0.00 | TRUE |
21 | NTR | Blood | CRIM1 | 0.09 | 0.10 | lasso | 6 | 0.11 | 3.1e-32 | 11.30 | -11.6 | 5.4e-31 | 0.03 | 1.00 | 0.00 | FALSE |
22 | ROSMAP | Brain Pre-frontal Cortex | NDUFAF7 | 0.13 | 0.07 | enet | 48 | 0.10 | 1.8e-12 | -1.49 | 6.1 | 1.3e-09 | 0.03 | 1.00 | 0.00 | TRUE |
23 | ROSMAP | Brain Pre-frontal Cortex | CYP1B1 | 0.08 | 0.00 | blup | 584 | 0.02 | 2.2e-03 | -4.09 | 8.4 | 3.2e-17 | 0.06 | 0.12 | 0.03 | TRUE |
24 | ROSMAP | Brain Pre-frontal Cortex | FEZ2 | 0.41 | 0.55 | lasso | 5 | 0.58 | 3.1e-93 | 11.43 | -11.8 | 2.5e-32 | 0.02 | 1.00 | 0.00 | FALSE |
25 | YFS | Blood | FEZ2 | 0.40 | 0.52 | bslmm | 615 | 0.55 | 7.7e-222 | 10.76 | 7.8 | 6.1e-15 | -0.02 | 1.00 | 0.00 | FALSE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FEZ2 | 0.01 | 0.01 | blup | 85 | 0.01 | 1.0e-03 | 10.95 | -13.5 | 1.1e-41 | 0.01 | 0.31 | 0.10 | FALSE |
27 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FEZ2 | 0.06 | 0.05 | lasso | 4 | 0.04 | 3.3e-03 | 11.98 | -11.6 | 4.3e-31 | 0.03 | 0.20 | 0.06 | FALSE |
28 | The Cancer Genome Atlas | Colon Adenocarcinoma | FEZ2 | 0.11 | 0.03 | blup | 84 | 0.07 | 6.1e-05 | 12.73 | -9.2 | 4.5e-20 | 0.02 | 0.58 | 0.03 | FALSE |
29 | The Cancer Genome Atlas | Esophageal Carcinoma | FEZ2 | 0.11 | 0.01 | blup | 87 | 0.02 | 7.1e-02 | 10.01 | -10.0 | 2.1e-23 | 0.01 | 0.06 | 0.04 | FALSE |
30 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FEZ2 | 0.04 | 0.00 | blup | 88 | 0.02 | 6.1e-03 | 9.97 | -8.8 | 1.6e-18 | 0.01 | 0.13 | 0.02 | FALSE |
31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CRIM1 | 0.05 | 0.04 | lasso | 2 | 0.03 | 3.2e-04 | -9.51 | -9.5 | 2.6e-21 | -0.01 | 0.23 | 0.19 | FALSE |
32 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FEZ2 | 0.06 | 0.05 | blup | 87 | 0.08 | 1.4e-08 | 11.43 | -10.6 | 2.5e-26 | 0.01 | 1.00 | 0.00 | FALSE |
33 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FAM82A1 | 0.05 | 0.03 | blup | 135 | 0.03 | 3.0e-03 | -2.78 | 5.6 | 1.9e-08 | 0.05 | 0.04 | 0.52 | FALSE |
34 | The Cancer Genome Atlas | Stomach Adenocarcinoma | QPCT | 0.07 | 0.00 | blup | 68 | 0.04 | 1.3e-03 | 3.05 | -6.5 | 1.1e-10 | -0.02 | 0.01 | 0.17 | TRUE |
35 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FEZ2 | 0.18 | 0.21 | lasso | 6 | 0.21 | 5.3e-08 | -14.18 | -15.2 | 5.7e-52 | 0.02 | 0.00 | 1.00 | TRUE |
36 | The Cancer Genome Atlas | Thyroid Carcinoma | FEZ2 | 0.07 | 0.06 | blup | 87 | 0.06 | 2.4e-06 | 10.91 | -8.0 | 1.5e-15 | 0.02 | 0.97 | 0.00 | FALSE |