Hub : Genes

SLC30A6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0380 0.0200 7.8e-03 0.013 0.018 0.002 0.016 0.002 9.2e-03 0.00270 0.17000 0.0039 0.19000
2 GTEx Adipose Subcutaneous 0.0910 0.0480 1.4e-03 -0.003 NA 0.013 NA 0.013 7.5e-01 NA 0.02800 NA 0.02700
3 GTEx Artery Tibial 0.0776 0.0446 7.4e-03 -0.002 NA 0.003 NA 0.002 5.8e-01 NA 0.18000 NA 0.23000
4 GTEx Esophagus Gastroesophageal Junction 0.0850 0.0470 7.1e-03 0.026 NA 0.012 NA 0.012 3.8e-02 NA 0.11000 NA 0.11000
5 GTEx Esophagus Muscularis 0.0500 0.0260 1.8e-03 0.029 NA 0.020 NA 0.011 6.9e-03 NA 0.02100 NA 0.07100
6 GTEx Muscle Skeletal 0.0550 0.0254 1.8e-05 0.035 NA 0.027 NA 0.036 2.2e-04 NA 0.00100 NA 0.00018
7 GTEx Stomach 0.0900 0.0400 6.0e-04 0.088 NA 0.051 NA 0.076 5.1e-05 NA 0.00180 NA 0.00017
8 GTEx Thyroid 0.0500 0.0220 6.0e-05 0.045 NA 0.040 NA 0.040 2.1e-04 NA 0.00048 NA 0.00050
9 METSIM Adipose 0.0401 0.0234 3.4e-04 0.014 0.019 0.022 0.023 0.018 2.8e-03 0.00071 0.00024 0.0002 0.00083
10 ROSMAP Brain Pre-frontal Cortex 0.0248 0.0133 5.3e-03 0.001 0.013 0.001 0.010 0.003 2.6e-01 0.00770 0.23000 0.0150 0.12000
11 TCGA Kidney Renal Clear Cell Carcinoma 0.0308 0.0209 2.1e-03 0.015 0.009 -0.002 NA 0.008 7.4e-03 0.02900 0.65000 NA 0.04100

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.4 0.6 2.2 -0.8 1.2 1.5 0.3 -0.2 -0.1 1.1 -0.5 -0.7 -0.4 -0.0
Bipolar Disorder or Schizophrenia 0.3 0.8 2.4 -1.3 0.3 1.5 0.8 0.0 0.1 1.6 -0.6 -0.7 -0.6 -0.4
Depressed Affect (Nagel 2018) 0.6 1.3 4.4 -1.0 -0.5 -1.4 1.8 0.7 -0.1 1.6 -0.4 -0.3 -2.1 0.2
Depression (Nagel 2018) 0.4 0.6 2.1 0.4 -0.1 -0.5 1.4 0.7 -0.2 1.1 0.8 0.4 -1.1 0.1
Intelligence (Savage-Jansen 2018) 3.9 11.9 20.6 2.5 -4.1 -2.3 -3.7 -4.2 -4.5 -3.3 -3.5 -3.1 -0.9 -4.2
Neuroticism (Nagel 2018) 0.7 1.7 7.7 -0.1 -1.1 -2.3 1.7 0.3 -0.7 0.8 -0.3 -0.6 -2.8 -0.5
Schizophrenia (2018) 0.2 0.5 1.3 -1.0 -0.6 0.9 0.9 0.2 0.1 1.1 -0.4 -0.4 -0.4 -0.6
Schizophrenia vs Biploar Disorder 0.8 1.0 2.7 0.1 -1.5 -1.6 -0.1 -0.7 -0.5 -0.8 -1.2 -0.6 -0.6 -1.6
Worry (Nagel 2018) 0.4 0.8 3.2 0.1 0.3 -1.8 1.2 0.9 -0.2 0.4 0.6 0.8 -1.6 -0.1
Alzheimer’s Disease (in mother) 0.6 0.7 1.9 -0.5 1.4 1.0 0.6 1.2 0.5 0.4 0.8 1.1 0.5 0.3
Alzheimer’s Disease (in father) 1.5 1.7 6.7 2.6 -1.8 -0.9 -0.4 -1.3 -0.7 -1.6 0.9 -0.8 -0.5 -1.1
Alzheimer’s Disease (including proxy) 0.2 0.3 1.3 1.1 -0.1 0.2 -0.0 0.1 -0.3 -0.6 0.9 -0.2 -0.0 -1.0
Crohns Disease (2017) 0.8 1.7 3.0 1.7 -0.7 -0.6 -1.7 -1.4 -1.6 -1.4 -0.5 -1.6 -0.2 -1.6
Irritable Bowel Disease (IBD) 1.6 3.8 6.7 2.4 -1.6 -1.0 -2.6 -2.2 -2.4 -2.2 -1.1 -1.9 -0.3 -2.5
Ulcerative Colitis (UC) 1.0 2.0 4.4 1.2 -1.2 -1.0 -2.1 -1.6 -1.8 -1.3 -1.1 -1.1 -0.1 -1.8
Major Depression (MDD) 2.8 3.4 8.1 -1.0 0.9 1.0 2.9 2.4 2.0 1.8 1.8 2.0 1.5 1.8
Reaction Time 0.8 1.6 7.4 -1.5 0.2 -0.8 1.6 0.6 0.0 2.0 0.1 -0.0 -2.7 -0.4
Verbal and Numeric Reasoning (VNR) 2.6 6.3 13.0 2.0 -3.6 -1.2 -2.1 -2.7 -2.9 -2.8 -2.6 -2.2 0.2 -3.4
Breast Cancer 0.4 0.9 2.7 0.6 1.4 1.6 -1.0 -0.7 -0.4 -1.0 -0.3 0.2 1.0 0.5
Ovarian Cancer 0.1 0.2 0.4 0.5 -0.3 0.0 -0.1 -0.5 -0.6 -0.6 -0.5 -0.1 0.0 -0.5
Prostate Cancer 0.6 0.8 3.9 -2.0 0.8 0.6 -0.5 -0.1 -0.5 0.6 -1.0 -0.4 -1.4 0.3
Age at First Birth 1.2 1.7 7.2 1.8 -2.7 -0.7 -1.3 -1.1 -0.5 -1.5 0.6 -0.2 1.4 0.3
Bipolar Disorder (2011) 1.1 1.0 2.1 -1.4 1.4 0.7 -0.1 -0.5 -0.6 1.0 -1.4 -1.1 -1.1 -0.8
Body Mass Index (BMI) (2010) 2.3 3.2 7.3 1.2 -1.7 -2.7 -1.0 -1.9 -2.0 -1.6 -1.5 -0.9 -2.2 -2.2
Coronary Artery Disease (CAD) 1.3 1.6 4.5 -0.5 -0.8 -1.0 -0.6 -0.8 -1.4 -0.5 -2.1 -1.6 -1.8 -1.3
Crohns Disease (2012) 1.2 1.9 4.0 0.5 -1.7 -2.0 -1.1 -1.5 -1.7 -0.8 -1.4 -1.6 -1.1 -1.1
Mean Putamen Volume 3.9 4.4 7.1 1.5 -1.5 1.1 -2.4 -2.7 -2.4 -2.3 -2.5 -2.6 0.1 -2.5
Fasting Glucose 1.0 1.2 2.6 0.3 -1.5 -0.2 -0.4 -1.1 -1.2 -0.4 -1.4 -1.4 -1.6 -1.2
HbA1C 0.4 0.4 1.5 0.0 1.0 0.5 1.1 0.4 0.4 0.2 0.6 1.2 -0.0 0.5
HDL Cholesterol 0.8 1.3 3.6 1.7 -0.8 1.4 -0.5 -0.9 -0.6 -1.5 -0.1 -0.5 1.9 -1.0
LDL Cholesterol 0.4 0.7 2.9 -0.7 -1.4 -0.8 1.7 0.3 0.1 0.3 -0.6 0.4 -0.6 -0.7
Lupus 0.6 0.9 2.5 0.1 0.4 -0.4 -0.3 -1.3 -0.7 0.4 -1.3 -1.0 -1.3 -1.6
Neuroticism (2016) 0.8 1.2 5.4 -0.8 -1.2 -0.9 -0.3 -0.9 -0.9 0.0 -1.2 -1.0 -2.3 -0.8
Primary Biliary Cirrhosis 2.6 3.6 7.4 1.5 -1.6 -1.5 -1.3 -2.1 -2.5 -2.3 -2.3 -1.6 -0.3 -2.7
Rheumatoid Arthritis 0.6 0.8 2.0 0.7 0.0 0.5 0.3 0.6 1.3 -0.6 1.4 1.2 0.9 1.2
Schizophrenia (2014) 0.4 0.8 2.8 -1.5 0.3 0.5 0.6 -0.1 -0.1 1.7 -1.1 -0.7 -1.1 -0.8
Triglycerides 0.2 0.3 1.5 -0.8 -0.4 -0.3 0.4 0.3 -0.1 1.2 -0.6 -0.6 -0.3 0.1
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.6 0.1 0.3 -0.8 -0.2 -0.2 -0.2 0.2 0.5 -0.1 -0.7 -0.0
Ulcerative Colitis 1.6 2.4 4.7 0.3 -0.7 -1.7 -2.2 -1.3 -1.7 -1.2 -1.9 -2.0 -1.1 -1.7
Blood Eosinophil Count 0.3 2.2 8.1 0.2 0.9 0.4 0.2 1.1 1.9 0.3 1.8 1.6 2.8 1.9
Blood Platelet Count 1.2 13.6 25.3 -3.5 3.9 5.0 3.8 4.5 3.6 4.0 2.1 3.0 2.8 3.5
Blood Red Count 0.1 0.7 2.6 -1.6 0.3 0.7 -1.4 -0.1 0.1 0.7 -0.7 -0.4 -0.7 0.9
Blood White Count 1.2 8.8 13.8 -1.2 2.9 3.7 3.0 3.4 2.6 3.4 2.7 2.6 3.5 2.8
Heel T-Score 0.6 4.5 20.3 -1.5 0.1 -2.9 -0.3 -1.4 -1.9 0.8 -2.8 -1.6 -4.5 -1.4
BMI 0.1 0.6 2.1 0.8 -0.5 -0.1 1.1 0.5 0.2 0.7 1.2 1.4 -0.6 -0.1
Height 0.6 12.4 53.6 5.3 -3.8 2.8 -2.4 -1.4 0.2 -4.5 1.5 0.3 7.3 -1.3
Waist Hip Ratio (WHR) 1.3 6.0 14.7 -2.9 3.8 2.0 2.0 2.7 1.8 3.6 0.8 1.2 -0.1 3.0
Systolic Blood Pressure 0.5 2.6 10.0 -2.2 3.2 1.3 0.5 1.2 0.8 2.7 0.1 0.7 0.0 1.5
Smoking Status 4.9 11.8 19.4 -3.0 3.1 2.5 4.0 4.3 3.7 4.4 3.0 3.3 1.6 3.8
Allergy or Eczema 0.4 1.0 4.8 -2.2 0.2 -0.3 -1.0 0.1 0.4 -0.1 -1.4 0.7 -1.5 -0.1
Cardiovascular Disease 1.6 5.2 12.8 -2.8 3.6 3.0 1.9 2.3 1.3 3.2 0.7 0.4 -1.3 2.2
Hypothyroidism (self reported) 0.8 1.8 3.8 -0.1 1.3 1.9 1.0 1.4 1.7 1.0 1.9 0.7 1.4 1.3
Respiratory disease 0.9 2.1 4.9 -2.2 1.7 1.0 1.4 1.4 1.6 2.0 0.3 0.8 -0.1 1.8
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.5 -1.0 0.3 0.7 0.7 0.9 0.4 1.2 0.2 0.6 0.1 0.8
Lung FEV1/FVC ratio 0.5 2.6 7.2 0.3 1.0 0.9 0.6 1.3 1.6 0.8 2.7 2.5 2.2 1.6
Lung FVC 0.4 2.3 5.2 -1.8 -1.4 -2.3 -0.0 -0.8 -0.7 0.4 -2.1 -1.8 -2.1 -0.9
Neuroticism 0.7 1.8 5.0 -1.4 0.9 -1.0 2.2 1.5 0.8 1.5 0.2 1.0 -1.9 0.7
Chronotype (morning person) 0.9 2.0 11.4 0.8 -2.1 1.0 0.3 -0.4 0.4 -1.9 -0.6 0.0 3.4 -0.6
Hair Pigment 0.1 1.5 4.8 -0.4 0.2 1.3 1.3 1.2 1.4 0.7 1.1 0.8 2.2 1.3
Tanning 0.1 0.7 2.6 0.9 0.1 -0.1 0.0 -0.9 -1.2 0.1 -0.3 -0.6 -1.0 -1.6
Hand grip strength (left) 1.7 4.5 7.8 0.9 -2.3 -2.4 -1.8 -2.6 -2.4 -2.3 -2.8 -1.9 0.1 -2.3
Number of treatments/medications taken 2.1 3.8 8.2 -2.4 2.1 2.2 2.5 2.2 1.4 2.9 0.8 0.8 -0.9 2.0
Average weekly spirits intake 1.1 1.3 3.5 1.9 0.6 1.9 -0.2 0.1 -0.1 -0.7 1.6 0.9 1.7 0.7
Sensitivity / hurt feelings 0.6 1.1 4.2 -0.2 -0.5 -1.3 0.3 -0.5 -0.9 -0.3 -1.1 -1.7 -2.0 -0.6
Frequency of depressed mood in last 2 weeks 1.2 1.6 5.3 -1.5 0.6 -0.7 2.0 1.5 1.2 2.3 0.5 0.7 -0.7 0.8
Hearing difficulty/problems: Yes 0.6 0.9 2.7 -0.7 -0.6 -1.3 -0.7 -0.5 -1.3 0.2 -1.3 -0.7 -1.7 -0.5
Relative age of first facial hair 2.4 4.9 8.5 1.8 -0.6 0.6 -2.8 -2.7 -2.9 -2.6 -2.9 -2.9 0.1 -1.9
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 2.3 -1.2 1.3 1.5 0.5 1.1 1.0 1.1 0.2 0.4 0.9 0.7
Ever used hormone-replacement therapy (HRT) 3.3 4.2 10.5 -1.9 1.9 1.0 3.2 2.3 1.4 3.2 1.9 1.4 -0.6 2.0
Ever had hysterectomy (womb removed) 0.5 0.6 2.6 0.6 -0.6 -1.6 -0.7 -0.4 -1.1 -0.4 -0.4 0.2 -0.9 -0.5
Systolic blood pressure, automated reading 0.5 1.4 4.5 -0.7 1.9 1.0 0.7 1.0 0.9 2.1 1.0 1.2 -0.1 1.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 3.1 -1.8 0.8 -0.7 1.0 1.1 0.5 1.1 0.0 1.1 -0.6 0.7
Angina 1.0 1.3 3.5 -1.6 0.9 1.5 0.8 0.5 -0.6 1.9 -1.1 0.4 -1.3 0.0
Medication for hormone replacement therapy 4.4 4.9 12.0 -0.8 1.0 1.4 3.5 2.7 2.3 2.5 2.9 2.2 0.7 2.6
Vitamin and mineral supplements 2.2 3.0 5.8 1.2 -1.6 0.6 -1.7 -2.1 -2.2 -1.5 -2.0 -2.2 0.2 -2.4
Supplements: Zinc 0.7 0.8 1.7 -1.1 1.3 -0.4 0.5 1.1 0.4 0.8 0.4 1.2 -0.7 0.9
Medication: Co-codamol 0.2 0.2 0.9 -0.7 0.5 -0.9 0.0 0.1 0.2 0.5 -0.2 0.0 0.2 0.0
Medication: Metformin 0.1 0.1 0.4 -0.0 -0.6 -0.6 -0.3 0.4 -0.1 -0.1 -0.5 0.3 0.3 -0.1
Diabetes (father) 0.7 0.9 1.9 -0.8 -0.5 -1.4 -1.2 -0.7 -0.8 -0.0 -1.0 -0.5 -1.4 -1.0
Diabetes (mother) 0.7 1.0 3.0 -0.1 1.0 0.4 0.8 0.7 0.9 0.7 1.1 0.5 1.7 1.5
Severe depression (siblings) 0.5 0.6 3.3 -0.6 0.4 0.5 1.8 0.9 0.3 1.0 0.3 0.3 0.1 0.5
Pack years adult smoking proportion 2.0 3.0 5.0 -1.7 1.2 -0.7 1.7 1.9 2.0 2.0 1.7 2.2 -1.2 2.0
Impedance of leg (right) 0.1 0.5 1.4 0.2 1.2 -0.3 0.8 0.5 0.7 1.0 0.8 0.5 0.7 0.5
Leg fat-free mass (left) 0.2 1.3 3.6 1.5 -1.9 0.8 -1.2 -0.8 -0.4 -1.8 -0.1 -0.6 1.3 -0.7
Trunk fat percentage 0.2 0.7 2.2 -0.1 0.2 0.4 1.3 0.8 0.8 1.5 0.6 1.0 -0.8 -0.0
Hand grip strength (right) 1.5 4.2 7.3 1.0 -2.1 -1.5 -1.7 -2.7 -2.0 -2.5 -2.7 -2.1 0.6 -2.4
Townsend deprivation index at recruitment 3.5 4.9 12.0 -3.1 2.4 1.0 2.5 2.3 2.4 3.5 0.8 1.5 -0.8 1.9
Current tobacco smoking 6.3 10.4 19.2 -3.1 3.4 1.4 3.4 3.8 3.6 4.4 2.8 3.3 1.0 3.6
Average weekly fortified wine intake 0.4 0.5 1.9 1.0 -0.8 -0.1 -1.4 -0.2 -0.0 -1.1 0.4 0.1 0.0 -0.1
Maternal smoking around birth 4.1 6.0 13.9 -1.7 2.8 0.7 3.7 2.9 2.5 3.3 2.0 1.8 0.4 2.8
Fed-up feelings 3.4 6.2 12.3 -3.5 2.5 -0.7 2.6 2.9 2.5 3.2 1.4 2.1 -1.7 2.9
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 6.5 -1.6 1.4 0.1 2.5 2.0 1.3 2.5 1.1 1.3 -1.4 1.2
Relative age voice broke 1.0 1.6 4.7 -0.2 -0.5 -0.0 -1.3 -1.4 -1.5 -0.8 -2.2 -2.0 -0.3 -1.3
Taking other prescription medications 1.0 1.6 3.5 -1.8 0.5 1.8 1.9 1.4 1.0 1.4 0.2 0.5 -0.8 1.3
Age when periods started (menarche) 0.3 0.7 3.4 1.8 -0.9 0.3 0.5 -0.1 -0.1 -0.6 0.5 -0.1 1.6 -0.6
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.2 0.8 0.1 0.0 0.5 0.5 0.4 -0.1 0.9 0.7 1.1 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.5 -0.0 -0.7 -1.2 -0.7 -0.4 0.0 0.4 -0.4 -0.3 -0.4 -0.1
Tinnitus: Yes, but not now, but have in the past 2.1 2.3 5.2 -0.5 0.9 1.4 2.3 1.9 1.9 1.2 1.8 1.1 1.2 1.5
Qualifications: CSEs or equivalent 0.9 1.2 2.9 -0.2 0.8 -0.0 1.7 1.5 1.3 1.1 1.2 1.1 0.7 1.2
Serious illness, injury or assault to yourself 0.3 0.4 1.7 0.0 0.4 1.3 -0.5 -0.3 -0.6 -0.4 -0.2 -1.1 0.6 -0.4
High blood pressure 0.6 1.7 6.7 -0.8 1.9 2.6 0.6 0.4 -0.1 1.6 0.1 -1.1 -1.7 0.5
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.5 -1.6 0.5 -0.2 -1.1 0.1 0.4 -0.5 -1.0 1.1 -0.7 0.3
Multivitamins +/- minerals 1.9 2.4 4.0 -1.0 1.4 -0.0 1.7 1.9 1.7 1.5 2.0 1.8 -0.7 1.9
Stomach or abdominal pain in last month 0.5 0.6 1.5 -0.3 0.2 -0.6 1.0 0.7 0.5 0.9 1.2 1.1 -0.5 0.7
Supplements: Glucosamine 1.7 2.2 8.4 -2.9 -0.4 1.4 2.1 1.4 1.0 2.4 -0.6 0.3 -0.4 0.6
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 3.2 -0.3 -0.7 -0.8 -0.8 -0.9 -1.6 -0.1 -1.2 -0.4 -1.8 -1.0
Medication: Atenolol 1.3 1.6 4.4 0.0 0.4 1.5 -1.3 -1.4 -1.4 -0.6 -1.6 -2.1 -0.7 -1.4
Medication: Levothyroxine sodium 0.2 0.3 1.0 0.7 0.3 0.0 0.1 0.5 0.2 0.6 1.0 -0.5 0.9 0.4
Sitting height 0.9 6.4 15.4 2.6 -3.9 0.4 -3.4 -2.0 -0.9 -3.9 -0.6 -1.4 3.5 -1.3
Chronic bronchitis/emphysema (father) 1.2 1.4 4.3 -1.0 0.3 -0.6 2.1 1.1 1.3 1.2 1.1 1.4 -1.1 0.9
High blood pressure (mother) 1.2 1.6 4.4 -2.1 1.1 -0.4 0.6 1.0 0.2 2.0 -0.1 -1.2 -1.8 1.6
Body mass index (BMI) 0.2 1.1 2.6 -0.4 0.3 -0.0 1.4 1.0 0.9 1.3 1.2 1.6 -1.1 0.8
Impedance of leg (left) 0.3 1.3 3.2 -0.8 1.7 0.0 1.5 1.2 1.3 1.8 0.8 0.8 0.2 0.9
Leg predicted mass (left) 0.3 1.4 3.9 1.5 -2.0 0.7 -1.3 -0.9 -0.5 -1.8 -0.2 -0.7 1.2 -0.8
Trunk fat mass 0.1 0.4 1.0 0.3 -0.5 0.4 1.0 0.6 0.8 0.9 0.7 1.0 -0.2 -0.1
Waist circumference 0.2 0.7 2.0 -0.2 0.5 1.0 1.0 0.9 0.8 1.4 0.7 1.1 -0.4 0.4
Number of incorrect matches in round 1.1 1.7 4.9 -1.6 1.5 -0.0 2.0 1.0 0.6 1.9 0.4 -0.1 -2.2 0.7
Past tobacco smoking 0.7 1.4 5.0 0.4 -0.3 -1.1 -2.2 -1.4 -1.0 -1.3 -1.2 -1.2 -0.6 -0.7
Alcohol usually taken with meals 0.3 0.4 1.0 0.7 -0.0 -0.2 -0.8 -0.9 -1.0 -0.9 -0.4 -0.4 0.1 -0.6
Nervous feelings 0.5 0.9 5.1 1.2 -0.4 -2.3 -0.4 -0.3 -0.6 -1.4 0.2 0.1 -0.2 -0.8
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 6.5 -0.7 1.4 -0.8 2.0 1.1 0.7 2.5 1.0 0.6 -1.1 0.9
Hearing difficulty/problems with background noise 0.7 1.1 4.0 -0.5 -0.2 -0.5 -0.8 -0.9 -1.3 -0.5 -2.0 -1.4 -0.9 -1.1
Hair/balding pattern: Pattern 2 3.0 3.8 6.5 -1.7 2.4 1.3 1.9 2.4 2.5 1.5 1.8 1.5 1.1 2.5
Had menopause 0.4 0.5 2.1 0.2 0.2 1.4 0.7 0.6 0.3 1.2 0.8 0.6 0.4 0.2
Had other major operations 0.2 0.2 0.9 -0.3 -0.7 -0.3 0.2 0.2 -0.4 -0.1 -0.6 -0.6 -0.9 -0.0
Forced vital capacity (FVC) 0.3 1.0 2.9 -0.4 -1.7 -0.8 -0.7 -0.9 0.0 -1.1 -1.5 -0.9 0.9 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.5 0.0 -0.5 -0.7 0.0 0.1 0.5 0.7 0.1 0.4 0.3 0.1
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 4.3 -1.9 1.2 -0.7 1.3 1.2 0.4 2.1 0.3 1.2 -1.4 1.0
Qualifications: None of the above 1.5 3.2 6.6 -1.4 1.8 0.5 2.1 1.8 1.7 2.6 1.8 2.3 -0.7 1.8
Financial difficulties in last 2 years 2.6 3.5 6.6 -2.4 1.4 1.0 2.1 2.6 2.5 1.8 1.3 1.7 0.4 2.3
Mouth/teeth dental problems 2.9 4.5 8.5 1.4 -1.9 -1.1 -2.9 -2.5 -1.7 -2.7 -2.2 -2.3 0.3 -2.7
Heart attack 0.8 1.0 3.0 -1.6 1.1 1.7 0.5 0.2 -0.1 1.5 -0.4 0.7 -1.0 0.4
Allergy 0.2 0.5 2.0 1.4 -0.1 -0.1 0.2 -0.3 -0.8 -0.0 0.4 -1.1 0.6 -0.6
Pain all over the body in last month 0.8 0.9 2.0 -0.6 1.2 1.4 1.4 1.0 0.7 0.9 0.9 0.3 -0.7 0.5
Diabetes (self-reported) 0.1 0.1 0.4 0.4 -0.1 -0.2 -0.1 -0.1 -0.6 0.1 0.3 -0.5 -0.3 0.2
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 3.1 0.2 -1.0 -1.1 -1.3 -1.3 -1.2 -1.8 -1.5 -0.6 -0.2 -0.9
Medication: Ramipril 0.7 0.9 4.9 -0.9 0.5 2.2 0.6 -0.0 -0.7 0.9 -0.8 -0.1 -1.1 -0.1
Medication: Simvastatin 1.1 1.5 3.3 -1.8 1.7 0.9 0.9 1.2 0.3 1.8 0.2 0.8 -1.8 0.8
Fluid intelligence score 2.3 4.8 8.7 1.8 -2.8 -1.2 -2.4 -2.4 -2.3 -3.0 -2.1 -1.4 0.3 -2.8
Illnesses of siblings 0.5 0.7 2.2 -0.7 -0.7 -1.5 0.3 0.5 1.3 0.2 0.7 0.1 0.4 1.2
Neuroticism score 0.7 1.4 4.2 -1.3 0.4 -1.3 2.0 1.2 0.6 1.3 0.3 0.6 -1.9 0.7
Weight 0.1 0.3 1.1 0.8 -1.1 0.4 0.1 0.1 0.3 -0.2 0.6 0.6 0.5 -0.2
Impedance of arm (right) 0.1 0.4 1.5 1.0 -0.1 0.6 -0.1 -0.4 -0.4 -0.2 -0.5 -0.9 0.6 -1.2
Arm fat percentage (right) 0.4 1.5 4.1 -0.3 0.6 0.6 2.0 1.2 1.1 1.8 1.3 1.8 -0.8 0.6
Trunk fat-free mass 0.3 1.7 5.3 1.8 -2.3 0.4 -1.0 -1.0 -0.4 -2.0 0.2 0.0 1.8 -0.5
Hip circumference 0.2 0.8 2.8 1.6 -1.7 0.0 -0.3 -0.6 -0.5 -0.8 0.2 0.1 -0.2 -1.4
Time employed in main current job 0.8 0.9 5.4 0.5 -1.2 0.5 -0.5 0.4 0.5 -0.9 0.3 1.1 2.3 0.4
Alcohol intake versus 10 years previously 0.5 0.7 3.1 -0.8 -0.3 -1.7 -0.1 -0.2 -0.0 0.1 -0.6 0.6 -1.8 -0.1
Father’s age at death 1.6 2.2 6.1 0.3 -2.5 0.0 -1.8 -1.6 -1.5 -1.4 -1.8 -1.2 -0.1 -1.7
Worrier / anxious feelings 0.2 0.4 1.6 -0.1 -0.1 -0.3 1.2 0.6 -0.4 0.3 0.4 0.6 -1.3 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 5.2 -1.4 1.2 0.3 2.3 1.7 0.5 2.3 0.9 1.2 -1.5 0.6
Falls in the last year 2.0 2.7 7.3 -1.2 1.8 2.7 2.1 1.8 1.5 2.1 1.0 1.0 0.7 1.1
Hair/balding pattern: Pattern 3 2.6 3.9 10.4 0.1 -1.0 -2.0 -1.1 -2.1 -2.7 0.0 -2.1 -0.6 -3.2 -3.1
Number of live births 0.2 0.3 1.9 -0.1 0.8 -0.3 -0.5 0.2 -0.6 0.3 -0.3 -0.2 -1.4 0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 2.2 -0.4 -1.3 -0.4 -0.2 -0.4 0.7 -1.1 -0.8 -0.3 1.5 -0.1
Pulse rate 0.7 1.1 2.9 0.1 0.7 1.3 1.0 1.2 1.0 0.7 1.1 0.2 1.7 1.3
Happiness 0.7 0.9 3.5 -1.5 0.8 -0.4 0.9 0.3 -0.3 1.9 -0.4 0.5 -1.3 -0.3
Noisy workplace 2.0 2.5 5.3 -2.0 0.6 0.5 2.2 2.1 1.9 2.3 0.6 1.6 0.2 1.4
Qualifications: A levels/AS levels or equivalent 2.1 4.7 11.8 -1.0 -1.4 -0.7 -2.4 -2.2 -1.9 -1.4 -3.4 -3.0 -2.3 -2.5
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 2.0 0.1 -0.4 -0.5 -1.3 -1.4 -0.9 -1.1 -1.3 -1.2 -1.3 -0.6
Mouth/teeth dental problems: Dentures 1.2 2.1 6.1 -1.9 1.6 -1.0 0.9 1.2 0.5 2.5 0.5 0.7 -1.8 1.8
Asthma 0.4 0.7 2.4 -1.5 0.4 -0.2 1.2 0.3 0.5 1.5 -0.3 -0.0 -1.0 0.4
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 6.1 -1.0 1.6 -0.3 1.9 2.1 1.9 0.8 1.6 2.5 0.2 2.2
Medication: Cholesterol lowering 0.4 0.6 4.1 -0.1 0.7 2.0 -0.1 -0.1 -0.7 1.0 -0.1 -0.4 -0.7 -0.3
Depression (self-reported) 0.2 0.2 1.0 -1.0 0.6 -0.4 0.3 0.1 0.4 0.4 -0.0 0.6 -0.7 0.1
Medication: Lansoprazole 0.3 0.3 0.9 0.8 -0.2 0.9 -0.3 0.0 -0.0 -0.3 0.9 0.1 -0.1 1.0
Prospective memory result 1.6 1.9 3.9 0.5 2.0 1.8 1.1 1.1 1.3 0.3 2.0 1.6 1.5 1.1
Lung cancer (father) 0.7 0.9 3.6 1.9 -0.0 -0.1 0.5 0.4 0.1 -0.7 1.6 1.1 0.9 0.6
Illnesses of mother 0.8 1.0 3.8 1.3 -1.9 0.0 -0.4 -0.9 -0.5 -1.1 -0.3 -0.6 0.8 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 4.4 -0.7 -1.2 -0.2 0.0 0.1 1.0 -0.8 -0.5 -0.0 2.1 0.4
Pulse wave Arterial Stiffness index 0.3 0.4 1.0 0.9 -0.8 0.1 -0.0 0.0 0.0 0.8 0.8 0.2 1.0 0.6
Impedance of arm (left) 0.3 1.2 4.0 1.1 -0.7 -0.4 -0.7 -1.0 -1.1 -0.7 -1.2 -1.7 0.2 -2.0
Arm fat mass (right) 0.2 1.0 2.6 0.1 0.1 0.3 1.5 1.0 1.0 1.2 1.3 1.6 -0.3 0.6
Trunk predicted mass 0.3 1.6 5.0 1.8 -2.2 0.4 -1.0 -1.0 -0.4 -2.0 0.1 -0.0 1.7 -0.5
Standing height 0.6 5.6 11.0 2.7 -3.2 1.0 -2.8 -1.9 -1.2 -3.1 -1.1 -2.0 3.3 -2.0
Length of working week for main job 0.1 0.1 0.2 0.2 0.5 -0.0 -0.4 -0.2 0.1 0.2 -0.0 -0.3 0.3 0.1
Exposure to tobacco smoke at home 0.3 0.4 1.7 -0.2 1.3 0.4 -0.2 0.9 0.5 0.2 0.6 0.1 0.1 0.7
Breastfed as a baby 0.7 0.8 2.0 1.0 0.3 0.1 -1.2 -1.0 -1.4 -1.2 -0.4 -0.5 0.3 -1.2
Tense / ‘highly strung’ 1.9 3.2 5.9 -2.1 2.2 -0.1 2.4 2.3 1.7 2.2 1.1 1.8 -0.9 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.5 -0.8 0.1 1.0 1.2 0.5 -0.6 1.0 -0.2 -0.4 -1.2 -0.2
Hair/balding pattern: Pattern 4 1.3 3.3 10.2 -3.2 -0.9 -1.9 1.9 1.0 0.8 2.3 -0.5 1.2 -2.9 -0.6
Birth weight of first child 1.4 2.6 5.3 1.9 -1.9 -1.1 -1.7 -1.6 -1.5 -2.3 -1.1 -0.9 -0.2 -2.3
Peak expiratory flow (PEF) 0.5 1.2 7.3 0.8 -0.5 0.6 0.1 -0.3 1.2 -1.6 0.5 0.4 2.7 0.6
Pulse wave reflection index 1.1 1.4 3.0 1.5 -1.6 -1.2 -1.7 -1.6 -1.4 -0.5 -0.5 -0.7 0.0 -0.5
Ever highly irritable/argumentative for 2 days 1.6 1.9 4.8 -0.1 1.6 1.9 2.2 0.9 1.3 1.7 1.3 1.2 0.9 0.9
Loud music exposure frequency 0.5 0.6 2.2 -0.2 1.2 -0.6 0.9 0.6 0.6 1.5 0.3 0.7 0.3 0.2
Qualifications: O levels/GCSEs or equivalent 2.6 4.1 10.9 -0.4 -2.3 -0.8 -2.1 -2.0 -2.2 -1.3 -3.3 -2.6 -1.3 -2.2
Mouth/teeth dental problems: Bleeding gums 2.1 2.7 6.9 -0.2 1.2 1.5 1.8 2.0 1.6 1.5 2.6 1.4 0.4 2.4
Blood clot in the leg (DVT) 1.3 1.7 3.5 1.8 -1.0 -0.5 -1.1 -1.9 -1.1 -1.7 -1.1 -1.2 -0.7 -1.7
Medication: Paracetamol 3.0 5.0 9.9 -2.1 2.1 0.2 3.2 3.0 2.3 2.4 2.0 2.4 0.2 2.5
Headache pain in last month 0.9 1.5 3.5 -1.1 1.0 0.1 1.7 1.9 0.8 1.5 1.2 0.8 -0.3 1.5
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 5.0 -0.1 -1.0 -2.2 -0.6 0.0 0.8 -0.8 0.2 0.7 1.0 0.5
Glaucoma (self-reported) 0.2 0.2 0.6 0.3 -0.6 0.4 -0.1 -0.5 -0.7 -0.4 -0.2 -0.8 -0.4 0.1
Gout (self-reported) 1.7 2.3 6.3 -2.5 1.4 0.7 2.0 1.8 0.9 2.2 -0.3 -0.3 -1.8 0.8
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.9 -0.4 1.1 0.9 0.5 1.2 1.2 1.3 1.4 0.3 0.7 1.0
Medication: Amlodipine 0.8 1.1 4.5 -0.5 2.1 2.0 0.2 0.7 0.0 1.5 0.3 -0.5 -0.1 0.8
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.6 -0.3 0.4 0.8 -0.0 0.2 0.2 -0.0 0.3 -0.1 0.4 0.3
Birth weight 0.8 1.8 7.2 0.6 -0.8 0.0 0.6 1.3 1.5 -0.7 1.7 2.7 1.8 1.0
Chronic bronchitis/emphysema (mother) 1.2 1.4 4.0 -1.1 0.9 0.1 2.0 0.9 1.1 1.9 1.0 0.6 -0.5 1.6
High blood pressure (siblings) 0.5 0.7 3.5 -0.8 1.2 1.9 -0.1 0.8 0.3 0.5 0.1 0.8 0.4 0.9
Forced vital capacity (FVC), Best measure 0.3 1.0 3.6 -0.2 -1.9 -0.4 -0.5 -0.5 0.1 -1.3 -1.1 -0.9 1.9 -0.4
Body fat percentage 0.3 1.3 3.5 -0.4 0.6 0.3 1.7 1.1 1.2 1.9 1.1 1.6 -1.0 0.5
Leg fat percentage (right) 0.6 2.3 4.7 -0.2 1.0 -0.4 2.0 1.2 1.5 2.2 1.9 2.1 -1.3 1.1
Arm fat-free mass (right) 0.1 0.7 2.5 0.9 -1.6 0.4 -0.9 -0.6 -0.2 -1.3 0.0 -0.1 1.1 -0.3
Exposure to tobacco smoke outside home 1.4 1.9 5.1 -0.2 1.8 0.3 1.0 1.5 1.3 1.4 1.9 1.0 0.5 2.3
Comparative body size at age 10 1.0 2.8 6.3 0.4 -1.0 -2.5 -1.4 -2.0 -1.8 -0.9 -1.7 -0.9 -2.4 -2.0
Number of full brothers 3.9 4.9 8.3 -2.9 2.7 2.0 2.1 2.6 2.1 2.6 1.2 1.7 0.6 2.6
Worry too long after embarrassment 3.6 6.1 10.2 2.2 -3.0 -1.9 -1.5 -2.7 -2.7 -2.7 -2.0 -2.4 -2.2 -3.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 4.2 -1.1 0.3 1.1 1.7 1.1 0.7 2.1 1.1 0.8 -1.0 1.0
Wheeze or whistling in the chest in last year 2.7 4.8 11.1 -2.0 1.9 1.5 3.1 2.6 2.1 3.3 1.6 1.8 -0.2 2.3
Number of children fathered 0.7 0.8 1.8 0.3 -0.9 0.6 1.3 0.5 0.6 1.0 0.9 1.3 1.3 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 7.1 1.5 0.8 1.3 0.3 0.6 0.4 -0.7 1.4 1.2 2.7 -0.3
Age at first live birth 3.5 6.3 10.6 2.0 -3.3 -1.0 -3.1 -3.2 -2.7 -2.7 -2.5 -2.1 0.1 -2.8
Pulse wave peak to peak time 0.3 0.3 0.8 -0.9 0.9 0.1 0.0 0.1 0.1 -0.6 -0.7 -0.1 -0.7 -0.6
Health satisfaction 1.2 1.6 3.7 -1.4 1.9 0.9 1.9 1.2 0.1 1.9 -0.0 1.0 -1.0 0.0
Shortness of breath walking on level ground 1.5 1.8 4.1 -0.9 1.5 2.0 1.4 1.2 1.7 0.8 0.7 1.7 0.6 1.3
Qualifications: College or University degree 2.9 9.0 19.2 1.9 -2.5 -0.4 -3.6 -3.9 -3.5 -3.4 -3.3 -2.6 -0.4 -4.4
Eye problems/disorders: None of the above 0.2 0.3 1.8 0.3 -0.2 -0.3 0.3 0.4 0.5 -0.1 0.6 0.5 1.3 -0.0
Mouth/teeth dental problems: Loose teeth 0.9 1.0 5.1 1.0 0.2 2.3 0.0 0.4 0.7 -0.9 0.9 0.4 1.5 0.5
Emphysema/chronic bronchitis 3.2 3.6 6.2 -1.6 1.7 0.3 2.0 2.5 2.1 1.8 2.0 2.5 1.4 2.1
Medication for pain relief, constipation, heartburn 4.3 7.3 12.1 2.1 -2.8 -1.9 -3.4 -3.5 -2.5 -3.1 -2.3 -3.1 0.1 -3.1
Neck or shoulder pain in last month 0.7 1.0 2.7 -0.8 1.1 1.1 1.1 1.3 0.6 1.1 0.8 0.2 -0.1 1.7
Medication: Blood pressure 0.9 1.5 6.6 -0.9 2.0 2.6 1.1 0.4 -0.1 1.4 -0.3 -0.4 -1.2 0.1
Angina (self-reported) 1.0 1.3 3.2 -1.7 0.9 1.7 0.7 0.2 -0.7 1.8 -1.4 0.2 -1.5 -0.1
Migraine (self-reported) 0.2 0.2 0.8 -0.1 -0.1 -0.4 -0.3 -0.5 -0.7 -0.0 -0.6 -0.4 -0.9 -0.4
Medication: Ibuprofen 1.8 2.1 4.7 -1.5 1.7 -0.4 1.5 2.0 1.5 0.8 1.0 1.7 0.0 2.2
Medication: Allopurinol 2.6 3.4 7.8 -2.7 2.1 0.8 2.0 2.2 1.7 2.8 0.1 0.8 -1.7 1.4
Medication: Omeprazole 3.3 3.9 9.9 -1.4 3.1 2.5 1.9 2.0 1.2 2.6 1.3 2.1 -0.1 1.7
Medication: Seretide 50 evohaler 0.6 0.7 2.0 -1.1 -0.2 -0.4 -0.8 -0.6 -0.5 0.5 -1.1 -1.4 -1.3 0.1
Mean time to correctly identify matches 1.0 1.8 11.7 -1.3 -0.4 -1.1 0.7 -0.0 -0.8 1.6 -0.7 -0.6 -3.4 -1.0
Heart disease (mother) 2.0 2.5 4.3 -1.5 1.5 1.1 2.1 1.8 1.7 1.7 1.1 2.1 0.2 1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.9 -1.2 0.8 0.1 1.0 0.8 1.7 1.5 0.4 0.2 0.9 1.3
Whole body fat mass 0.2 0.7 1.8 0.2 -0.1 0.4 1.1 0.8 1.0 1.1 1.1 1.4 -0.2 0.3
Leg fat mass (right) 0.3 1.0 2.5 0.1 0.3 0.3 1.2 0.9 1.2 1.3 1.6 1.6 -0.4 0.7
Arm predicted mass (right) 0.1 0.6 1.9 0.9 -1.4 0.6 -0.7 -0.3 0.1 -1.2 0.3 0.2 1.2 -0.1
Pulse rate, automated reading 0.5 1.7 3.8 -0.3 1.6 1.9 1.2 1.3 1.3 1.4 1.0 -0.0 2.0 1.0
Alcohol intake frequency. 0.8 1.8 6.7 -2.3 0.1 -2.1 0.0 0.3 -0.2 1.0 -1.2 -0.5 -2.6 0.3
Comparative height size at age 10 0.8 4.3 8.2 1.0 -2.7 -1.5 -2.9 -2.5 -1.9 -1.7 -2.1 -2.9 0.0 -1.9
Number of full sisters 2.1 2.5 7.2 -0.8 1.7 0.4 2.7 2.3 1.6 1.5 1.2 1.0 1.1 1.8
Suffer from ‘nerves’ 0.6 1.0 5.7 -0.3 0.8 -2.4 0.6 0.8 0.1 0.2 0.6 0.3 -1.7 0.6
Overall health rating 2.4 5.3 16.0 -2.0 2.1 0.8 3.4 2.5 1.4 4.0 1.3 2.6 -1.8 1.2
Chest pain or discomfort 2.9 4.1 8.4 -2.2 2.1 2.2 2.4 2.3 1.9 2.9 1.4 2.1 -0.2 1.7
Had major operations 0.9 1.0 3.3 0.0 -0.7 0.3 1.8 1.0 0.8 1.6 1.0 0.9 1.0 0.4
Age at last live birth 2.0 2.9 4.8 1.6 -2.0 -0.8 -1.8 -2.2 -2.1 -1.7 -1.8 -1.7 -0.5 -1.9
Family relationship satisfaction 1.2 1.5 4.5 -1.1 0.6 0.8 1.9 1.1 1.0 2.1 0.8 1.3 -0.2 1.2
Leg pain on walking 0.7 0.9 3.7 -0.4 0.4 0.8 1.9 1.0 0.6 1.3 0.9 1.0 -0.6 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.6 -0.8 0.6 0.1 0.0 0.6 0.6 0.4 0.2 0.5 -0.3 0.6
Commuting to job workplace: Car/motor vehicle 0.4 0.4 2.0 -1.0 0.9 1.4 -0.3 -0.1 0.0 0.2 -0.4 -0.7 -0.2 0.1
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.3 1.1 -0.7 -1.1 -0.7 -0.4 -0.7 -0.2 0.1 -0.1 0.5 -0.8
Medication: Aspirin 2.6 3.5 9.5 -2.0 1.9 2.1 1.9 1.9 1.1 3.1 1.1 1.9 -0.5 1.8
Supplements: Vitamin C 0.9 1.1 2.5 -1.3 1.6 0.9 0.5 0.9 1.3 0.5 0.6 1.4 0.4 1.3
Knee pain experienced in last month 1.8 2.7 7.0 -1.6 1.6 1.8 2.6 1.7 1.7 1.8 1.0 1.8 -0.1 1.4
Hypertension (Self-reported) 0.7 1.9 6.9 -0.8 2.2 2.6 1.1 0.7 0.0 1.7 0.4 -0.7 -1.6 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.8 3.2 9.4 -1.2 2.4 3.1 1.4 2.0 1.1 1.8 1.6 1.4 -0.1 2.0
Illnesses of father: Heart disease 1.4 1.9 10.1 -3.2 1.2 -0.7 -1.0 0.2 -0.6 1.0 -2.1 -0.0 -1.4 -0.2
Illnesses of siblings: Diabetes 0.8 1.0 3.1 -1.6 1.4 0.1 0.4 0.9 0.2 1.4 -0.3 -0.1 -1.8 0.5
Smoking status: Previous 0.3 0.5 2.2 0.2 -0.5 1.1 1.5 0.7 0.4 0.3 0.5 0.6 0.5 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.2 -1.5 -0.5 0.9 1.5 1.4 1.5 1.4 -0.0 -0.4 1.2 1.0
Whole body fat-free mass 0.3 1.4 4.3 1.6 -2.1 0.7 -1.1 -0.9 -0.4 -1.9 0.0 -0.2 1.6 -0.6
Leg fat-free mass (right) 0.2 1.3 3.6 1.2 -1.9 0.8 -1.3 -0.8 -0.5 -1.8 -0.4 -0.8 1.0 -0.8
Arm fat percentage (left) 0.2 0.9 2.8 -0.1 0.3 0.0 1.7 0.8 0.8 1.5 1.0 1.4 -1.1 0.2
Average weekly red wine intake 0.4 0.5 1.8 -0.4 -1.2 0.3 -0.2 -0.4 -0.7 -0.4 -1.4 -0.8 -0.5 -0.9
Handedness (chirality/laterality): Left-handed 0.6 0.8 3.1 1.6 -1.8 0.1 0.3 -0.8 -0.4 -1.2 0.5 0.1 -0.4 -0.4
Mood swings 0.6 1.1 3.4 -1.6 0.4 -0.9 1.2 0.7 -0.0 1.9 -0.5 0.3 -1.7 0.7
Loneliness, isolation 3.9 5.4 9.8 -2.4 1.4 1.1 3.1 3.1 2.8 3.0 2.0 2.2 -0.8 2.3
Long-standing illness, disability or infirmity 0.4 0.6 2.6 -0.2 1.0 1.6 0.1 -0.2 -1.0 0.4 -0.8 0.0 -1.0 -0.8
Ever had bowel cancer screening 1.4 1.7 4.2 0.4 -0.6 -1.0 -0.7 -1.3 -1.7 0.2 -1.6 -1.5 -1.6 -2.0
Diabetes diagnosed by doctor 0.4 0.7 2.2 -1.0 0.1 0.1 1.0 0.9 0.3 1.5 0.5 0.0 -0.8 1.2
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 5.0 -2.2 1.6 0.1 0.1 0.9 -0.3 1.8 -0.8 -1.0 -2.2 0.8
Friendships satisfaction 1.1 1.4 4.0 -1.0 0.9 0.1 1.7 1.5 0.8 1.7 0.4 2.0 0.5 0.6
Qualifications: nursing, teaching 2.9 4.5 10.6 -0.2 -0.3 -0.9 -2.9 -2.4 -2.2 -2.2 -3.2 -2.3 -1.4 -2.5
Commuting to job workplace: Walk 0.6 0.7 2.9 0.7 -0.9 -1.7 -0.5 -0.2 -1.1 -0.2 -0.4 -0.3 -0.9 -0.8
Eye problems/disorders: Cataract 0.3 0.3 0.7 0.3 0.6 0.9 -0.7 -0.5 -0.2 -0.6 -0.1 0.6 -0.8 -0.0
Mouth/teeth dental problems: Mouth ulcers 2.1 3.4 8.6 -1.5 1.4 0.5 2.9 2.0 1.9 2.2 1.6 2.1 -0.1 2.3
Medication for cholesterol 2.7 4.0 7.7 0.7 -1.8 -2.8 -2.7 -2.0 -1.7 -2.2 -2.4 -1.3 -0.6 -2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.6 -0.3 0.9 1.0 1.2 0.8 1.3 0.7 1.1 0.6 0.1 1.0
Back pain experienced in last month 1.1 1.6 3.8 -1.2 0.9 0.8 1.1 1.6 1.5 1.2 1.2 1.6 0.1 1.9
Mineral and other dietary supplements 1.1 1.5 6.2 2.5 0.1 0.4 -0.6 -0.4 0.4 -1.4 1.2 0.5 2.5 0.0
Breast cancer (self-reported) 0.3 0.3 1.3 -0.0 -0.6 -0.4 -1.1 -0.4 -0.1 -1.1 -0.8 -0.1 0.1 -0.1
Asthma (self-reported) 0.3 0.6 2.2 -1.4 0.1 -0.2 1.0 0.1 0.3 1.5 -0.6 -0.3 -1.0 0.1
Osteoporosis (self-reported) 0.8 1.0 3.6 -1.3 0.7 0.1 1.0 1.4 0.7 1.9 0.4 1.0 -0.3 0.6
Osteoarthritis (self-reported) 1.0 1.3 2.6 -0.3 -1.0 -0.4 -0.2 -1.2 -1.5 -0.8 -1.6 -1.3 -1.5 -1.5
Medication: Aspirin 2.8 3.7 10.7 -2.2 1.9 2.3 1.9 2.0 1.0 3.3 1.0 1.4 -0.8 1.7
Medication: Gliclazide 0.9 1.0 3.3 -1.3 -0.1 0.3 1.0 1.5 0.8 0.8 0.7 1.8 0.3 1.0
Illnesses of father: None of the above (group 1) 2.1 2.6 6.1 0.7 0.2 1.4 2.5 1.4 2.1 1.2 1.9 1.0 2.4 1.6
Smoking status: Current 6.0 9.6 17.1 -3.1 3.4 0.9 3.0 3.6 3.5 4.1 2.8 3.2 0.8 3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.5 -1.2 -1.0 0.1 0.5 0.1 0.2 0.3 -1.1 -0.2 0.2 -0.9
Whole body water mass 0.2 1.3 4.2 1.5 -2.0 0.7 -0.9 -0.7 -0.3 -1.8 0.1 -0.1 1.6 -0.5
Leg predicted mass (right) 0.3 1.4 3.8 1.2 -1.9 0.7 -1.4 -0.9 -0.6 -1.8 -0.5 -0.9 0.9 -0.9
Arm fat mass (left) 0.1 0.5 1.3 0.3 -0.2 0.0 1.1 0.6 0.6 0.8 0.9 1.1 -0.5 0.2
Number of self-reported non-cancer illnesses 1.0 1.8 8.6 -1.4 0.4 0.9 0.4 -0.0 -1.0 1.3 -1.4 -1.7 -2.9 -0.4
Average weekly champagne plus white wine intake 0.7 1.0 3.7 1.1 -0.5 0.6 -1.2 -0.5 -0.2 -1.2 -0.2 -1.9 1.2 -0.7
Miserableness 0.3 0.6 1.7 -0.5 -0.7 -0.3 1.2 0.1 -0.4 0.8 -0.5 -1.3 -1.1 0.0
Guilty feelings 0.8 1.2 6.8 0.0 -0.8 -0.8 2.6 0.8 0.8 1.2 1.3 1.0 -0.6 0.3
Wears glasses or contact lenses 1.2 1.3 2.9 -0.8 -1.4 1.0 -1.7 -0.8 -1.2 -1.1 -1.6 -0.9 -1.1 -0.5
Ever taken oral contraceptive pill 0.7 0.8 2.1 -1.5 1.4 0.4 -0.1 -0.1 -0.3 0.4 -1.2 -0.4 -1.4 -0.3
Hearing aid user 2.2 2.5 4.8 1.4 -1.5 -0.2 -1.4 -1.9 -2.2 -1.8 -1.6 -2.2 -0.5 -1.6
Mother’s age at death 0.4 0.5 1.7 0.7 1.3 1.1 0.1 0.2 0.1 -0.3 0.1 0.4 1.2 -0.0
Financial situation satisfaction 3.5 4.4 11.1 -3.3 1.0 0.4 2.9 2.5 2.1 3.2 0.6 1.4 -1.1 1.7
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.2 0.6 0.4 1.1 -0.1 -0.3 -0.4 0.0 -0.0 0.0 0.3 -0.3
Commuting to job workplace: Public transport 0.4 0.5 3.3 0.1 -0.9 -1.8 0.2 -0.3 0.4 0.0 0.2 -0.1 -0.5 0.6
Eye problems/disorders: Glaucoma 0.1 0.1 0.7 -0.1 -0.3 -0.4 0.8 0.2 -0.1 0.4 0.1 0.2 -0.5 0.3
Medication: Blood pressure 0.9 1.8 6.8 -0.9 1.6 2.6 1.0 1.1 0.7 1.8 1.2 -0.1 0.5 1.3
Pain type(s) experienced in last month: Hip pain 1.0 1.2 3.0 -1.6 -0.7 -0.6 1.5 1.2 1.7 1.0 0.1 0.5 -0.5 1.4
Supplements: Fish oil (including cod liver oil) 1.4 1.8 8.0 -1.4 -0.9 -1.4 -0.4 -0.4 -1.6 0.5 -1.5 -0.8 -2.8 -0.9
High cholesterol (Self-reported) 0.9 1.6 3.7 -1.8 1.9 1.9 0.0 0.9 0.7 1.6 0.2 0.8 -0.4 1.6
Medication: Bendroflumethiazide 0.3 0.5 2.2 1.5 0.1 1.1 -0.1 -0.5 -0.6 -0.2 0.8 -0.8 -0.1 -0.3
Medication: Paracetamol 2.9 4.5 8.1 -1.7 2.3 0.7 2.8 2.9 2.1 2.2 2.1 2.3 0.9 2.4
Medication: Lisinopril 0.9 1.2 3.2 -0.4 1.8 1.8 -0.6 -0.7 -0.7 0.5 -1.4 -1.7 -0.3 -0.6
Medication: Atorvastatin 0.4 0.5 2.0 0.8 -0.4 1.4 -0.2 -0.6 -0.9 0.3 -0.4 -0.6 0.5 -1.0
Illnesses of father: High blood pressure 0.5 0.6 1.4 -0.3 0.8 -0.8 -0.9 -0.7 -0.7 -0.6 -1.2 -0.8 -1.1 -0.6
Alcohol drinker status: Never 0.4 0.5 1.2 -0.2 -0.6 -0.3 0.5 0.7 1.0 0.8 1.0 0.5 0.5 1.1
Ever smoked 1.0 1.7 5.2 -0.1 0.3 0.1 2.3 1.3 1.2 1.5 1.6 1.9 1.1 0.8
Basal metabolic rate 0.2 0.9 3.1 1.4 -1.8 0.6 -0.6 -0.5 -0.1 -1.4 0.3 0.1 1.4 -0.4
Leg fat percentage (left) 0.9 3.1 6.7 -0.8 1.3 -0.0 2.5 1.7 1.8 2.6 1.9 2.3 -1.6 1.3
Arm fat-free mass (left) 0.1 0.6 1.8 0.8 -1.0 0.9 -0.2 0.0 0.4 -0.8 0.6 0.7 1.3 0.3
Number of operations (self-reported) 0.5 0.7 2.0 -0.2 -1.2 -0.6 1.1 1.4 0.6 1.0 0.8 0.2 0.1 0.7
Average weekly beer plus cider intake 1.8 2.6 7.5 0.1 1.3 2.7 0.7 1.3 1.8 0.7 1.9 1.5 2.0 1.9
Irritability 2.9 4.9 14.4 -2.7 2.0 0.3 3.3 2.4 1.5 3.8 0.9 0.5 -2.1 1.8
Risk taking 0.7 1.1 3.3 -0.2 1.3 1.7 1.8 0.9 0.9 0.9 1.0 0.5 0.4 0.5
Ever had prostate specific antigen (PSA) test 1.2 1.4 2.7 -0.9 0.7 1.5 1.5 1.6 1.2 1.5 1.0 0.9 0.7 1.0
Fractured/broken bones in last 5 years 1.3 1.7 7.1 -2.1 1.2 -0.0 0.1 -0.3 -1.2 1.0 -1.7 -0.7 -2.7 -0.4
Age started oral contraceptive pill 4.4 5.5 10.6 1.6 -2.6 -0.9 -2.6 -3.2 -2.4 -2.1 -2.6 -2.3 -0.3 -3.2
Diastolic blood pressure, automated reading 0.2 0.6 3.5 -0.4 1.9 0.9 0.2 0.3 0.3 0.9 -0.0 0.2 -0.6 0.5
Ever depressed for a whole week 1.1 1.3 5.0 -2.2 -0.1 -0.3 1.1 1.1 0.6 1.4 0.2 0.4 -1.1 1.7
Unable to work because of sickness or disability 0.8 1.1 2.3 -0.0 1.5 0.2 1.2 1.0 1.2 1.4 1.4 0.4 -0.4 1.2
Commuting to job workplace: Cycle 0.4 0.5 1.6 0.9 -0.5 -0.9 0.5 0.4 0.6 0.1 0.9 0.6 1.3 0.2
Myopia 1.1 1.5 3.9 0.4 -1.6 -0.0 -1.1 -1.3 -1.1 -1.5 -1.4 -2.0 -1.2 -0.6
Vascular/heart problems diagnosed by doctor 0.5 1.4 6.6 0.3 -1.7 -2.6 -0.6 -0.2 0.4 -1.5 -0.2 0.7 1.5 -0.2
Cholesterol lowering medication 1.7 2.5 5.8 -1.9 1.7 0.9 1.7 1.9 1.2 2.4 1.0 1.2 -0.7 1.9
Medication: Omeprazole (e.g. Zanprol) 2.9 3.6 9.7 -1.6 2.6 3.1 2.1 1.8 0.8 2.7 0.7 1.5 0.0 1.6
Pain experienced in last month 1.7 2.9 5.4 2.0 -1.7 -1.2 -2.3 -2.2 -1.4 -2.2 -1.1 -1.1 0.9 -1.8
Supplements: Calcium 0.7 0.8 4.9 -2.2 0.2 -0.3 0.3 0.8 0.1 0.9 -0.9 0.7 -0.6 0.3
Basal cell carcinoma (self-reported) 3.5 4.2 7.2 -0.8 0.6 2.1 2.6 2.7 2.3 2.4 2.6 2.1 -0.1 2.1
Heart attack/myocardial infarction (self-reported) 0.7 1.0 3.2 -1.6 1.0 1.8 0.3 0.1 -0.1 1.4 -0.5 0.6 -0.9 0.4
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 2.5 1.5 -0.7 -0.2 -1.0 -1.6 -1.1 -1.6 -1.0 -1.1 -0.6 -1.5
Heart disease (siblings) 0.2 0.2 0.7 0.5 0.6 0.5 0.4 -0.1 -0.8 -0.2 -0.3 -0.3 0.6 -0.5
Alcohol drinker status: Previous 0.9 1.0 4.4 -2.1 1.5 1.1 0.2 0.9 0.6 0.4 -0.6 0.5 0.5 0.8
Pack years of smoking 1.9 2.8 6.2 -1.5 1.3 -0.5 1.6 1.8 1.8 1.9 1.7 2.5 -1.0 2.0
Impedance of whole body 0.0 0.2 0.5 0.2 0.7 0.1 0.2 0.1 0.1 0.5 -0.3 -0.7 0.5 -0.7
Leg fat mass (left) 0.3 1.2 2.6 -0.2 0.3 0.4 1.4 1.1 1.3 1.5 1.5 1.6 -0.7 0.7
Arm predicted mass (left) 0.1 0.5 1.6 0.8 -1.2 1.0 -0.1 -0.0 0.4 -0.7 0.5 0.4 1.3 0.2