Hub : Genes

SLC30A6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0380	0.0200	7.8e-03	0.013	0.018	0.002	0.016	0.002	9.2e-03	0.00270	0.17000	0.0039	0.19000
2	GTEx	Adipose Subcutaneous	0.0910	0.0480	1.4e-03	-0.003	NA	0.013	NA	0.013	7.5e-01	NA	0.02800	NA	0.02700
3	GTEx	Artery Tibial	0.0776	0.0446	7.4e-03	-0.002	NA	0.003	NA	0.002	5.8e-01	NA	0.18000	NA	0.23000
4	GTEx	Esophagus Gastroesophageal Junction	0.0850	0.0470	7.1e-03	0.026	NA	0.012	NA	0.012	3.8e-02	NA	0.11000	NA	0.11000
5	GTEx	Esophagus Muscularis	0.0500	0.0260	1.8e-03	0.029	NA	0.020	NA	0.011	6.9e-03	NA	0.02100	NA	0.07100
6	GTEx	Muscle Skeletal	0.0550	0.0254	1.8e-05	0.035	NA	0.027	NA	0.036	2.2e-04	NA	0.00100	NA	0.00018
7	GTEx	Stomach	0.0900	0.0400	6.0e-04	0.088	NA	0.051	NA	0.076	5.1e-05	NA	0.00180	NA	0.00017
8	GTEx	Thyroid	0.0500	0.0220	6.0e-05	0.045	NA	0.040	NA	0.040	2.1e-04	NA	0.00048	NA	0.00050
9	METSIM	Adipose	0.0401	0.0234	3.4e-04	0.014	0.019	0.022	0.023	0.018	2.8e-03	0.00071	0.00024	0.0002	0.00083
10	ROSMAP	Brain Pre-frontal Cortex	0.0248	0.0133	5.3e-03	0.001	0.013	0.001	0.010	0.003	2.6e-01	0.00770	0.23000	0.0150	0.12000
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0308	0.0209	2.1e-03	0.015	0.009	-0.002	NA	0.008	7.4e-03	0.02900	0.65000	NA	0.04100

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.6	2.2	-0.8	1.2	1.5	0.3	-0.2	-0.1	1.1	-0.5	-0.7	-0.4	-0.0
Bipolar Disorder or Schizophrenia	0.3	0.8	2.4	-1.3	0.3	1.5	0.8	0.0	0.1	1.6	-0.6	-0.7	-0.6	-0.4
Depressed Affect (Nagel 2018)	0.6	1.3	4.4	-1.0	-0.5	-1.4	1.8	0.7	-0.1	1.6	-0.4	-0.3	-2.1	0.2
Depression (Nagel 2018)	0.4	0.6	2.1	0.4	-0.1	-0.5	1.4	0.7	-0.2	1.1	0.8	0.4	-1.1	0.1
Intelligence (Savage-Jansen 2018)	3.9	11.9	20.6	2.5	-4.1	-2.3	-3.7	-4.2	-4.5	-3.3	-3.5	-3.1	-0.9	-4.2
Neuroticism (Nagel 2018)	0.7	1.7	7.7	-0.1	-1.1	-2.3	1.7	0.3	-0.7	0.8	-0.3	-0.6	-2.8	-0.5
Schizophrenia (2018)	0.2	0.5	1.3	-1.0	-0.6	0.9	0.9	0.2	0.1	1.1	-0.4	-0.4	-0.4	-0.6
Schizophrenia vs Biploar Disorder	0.8	1.0	2.7	0.1	-1.5	-1.6	-0.1	-0.7	-0.5	-0.8	-1.2	-0.6	-0.6	-1.6
Worry (Nagel 2018)	0.4	0.8	3.2	0.1	0.3	-1.8	1.2	0.9	-0.2	0.4	0.6	0.8	-1.6	-0.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.9	-0.5	1.4	1.0	0.6	1.2	0.5	0.4	0.8	1.1	0.5	0.3
Alzheimer’s Disease (in father)	1.5	1.7	6.7	2.6	-1.8	-0.9	-0.4	-1.3	-0.7	-1.6	0.9	-0.8	-0.5	-1.1
Alzheimer’s Disease (including proxy)	0.2	0.3	1.3	1.1	-0.1	0.2	-0.0	0.1	-0.3	-0.6	0.9	-0.2	-0.0	-1.0
Crohns Disease (2017)	0.8	1.7	3.0	1.7	-0.7	-0.6	-1.7	-1.4	-1.6	-1.4	-0.5	-1.6	-0.2	-1.6
Irritable Bowel Disease (IBD)	1.6	3.8	6.7	2.4	-1.6	-1.0	-2.6	-2.2	-2.4	-2.2	-1.1	-1.9	-0.3	-2.5
Ulcerative Colitis (UC)	1.0	2.0	4.4	1.2	-1.2	-1.0	-2.1	-1.6	-1.8	-1.3	-1.1	-1.1	-0.1	-1.8
Major Depression (MDD)	2.8	3.4	8.1	-1.0	0.9	1.0	2.9	2.4	2.0	1.8	1.8	2.0	1.5	1.8
Reaction Time	0.8	1.6	7.4	-1.5	0.2	-0.8	1.6	0.6	0.0	2.0	0.1	-0.0	-2.7	-0.4
Verbal and Numeric Reasoning (VNR)	2.6	6.3	13.0	2.0	-3.6	-1.2	-2.1	-2.7	-2.9	-2.8	-2.6	-2.2	0.2	-3.4
Breast Cancer	0.4	0.9	2.7	0.6	1.4	1.6	-1.0	-0.7	-0.4	-1.0	-0.3	0.2	1.0	0.5
Ovarian Cancer	0.1	0.2	0.4	0.5	-0.3	0.0	-0.1	-0.5	-0.6	-0.6	-0.5	-0.1	0.0	-0.5
Prostate Cancer	0.6	0.8	3.9	-2.0	0.8	0.6	-0.5	-0.1	-0.5	0.6	-1.0	-0.4	-1.4	0.3
Age at First Birth	1.2	1.7	7.2	1.8	-2.7	-0.7	-1.3	-1.1	-0.5	-1.5	0.6	-0.2	1.4	0.3
Bipolar Disorder (2011)	1.1	1.0	2.1	-1.4	1.4	0.7	-0.1	-0.5	-0.6	1.0	-1.4	-1.1	-1.1	-0.8
Body Mass Index (BMI) (2010)	2.3	3.2	7.3	1.2	-1.7	-2.7	-1.0	-1.9	-2.0	-1.6	-1.5	-0.9	-2.2	-2.2
Coronary Artery Disease (CAD)	1.3	1.6	4.5	-0.5	-0.8	-1.0	-0.6	-0.8	-1.4	-0.5	-2.1	-1.6	-1.8	-1.3
Crohns Disease (2012)	1.2	1.9	4.0	0.5	-1.7	-2.0	-1.1	-1.5	-1.7	-0.8	-1.4	-1.6	-1.1	-1.1
Mean Putamen Volume	3.9	4.4	7.1	1.5	-1.5	1.1	-2.4	-2.7	-2.4	-2.3	-2.5	-2.6	0.1	-2.5
Fasting Glucose	1.0	1.2	2.6	0.3	-1.5	-0.2	-0.4	-1.1	-1.2	-0.4	-1.4	-1.4	-1.6	-1.2
HbA1C	0.4	0.4	1.5	0.0	1.0	0.5	1.1	0.4	0.4	0.2	0.6	1.2	-0.0	0.5
HDL Cholesterol	0.8	1.3	3.6	1.7	-0.8	1.4	-0.5	-0.9	-0.6	-1.5	-0.1	-0.5	1.9	-1.0
LDL Cholesterol	0.4	0.7	2.9	-0.7	-1.4	-0.8	1.7	0.3	0.1	0.3	-0.6	0.4	-0.6	-0.7
Lupus	0.6	0.9	2.5	0.1	0.4	-0.4	-0.3	-1.3	-0.7	0.4	-1.3	-1.0	-1.3	-1.6
Neuroticism (2016)	0.8	1.2	5.4	-0.8	-1.2	-0.9	-0.3	-0.9	-0.9	0.0	-1.2	-1.0	-2.3	-0.8
Primary Biliary Cirrhosis	2.6	3.6	7.4	1.5	-1.6	-1.5	-1.3	-2.1	-2.5	-2.3	-2.3	-1.6	-0.3	-2.7
Rheumatoid Arthritis	0.6	0.8	2.0	0.7	0.0	0.5	0.3	0.6	1.3	-0.6	1.4	1.2	0.9	1.2
Schizophrenia (2014)	0.4	0.8	2.8	-1.5	0.3	0.5	0.6	-0.1	-0.1	1.7	-1.1	-0.7	-1.1	-0.8
Triglycerides	0.2	0.3	1.5	-0.8	-0.4	-0.3	0.4	0.3	-0.1	1.2	-0.6	-0.6	-0.3	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.6	0.1	0.3	-0.8	-0.2	-0.2	-0.2	0.2	0.5	-0.1	-0.7	-0.0
Ulcerative Colitis	1.6	2.4	4.7	0.3	-0.7	-1.7	-2.2	-1.3	-1.7	-1.2	-1.9	-2.0	-1.1	-1.7
Blood Eosinophil Count	0.3	2.2	8.1	0.2	0.9	0.4	0.2	1.1	1.9	0.3	1.8	1.6	2.8	1.9
Blood Platelet Count	1.2	13.6	25.3	-3.5	3.9	5.0	3.8	4.5	3.6	4.0	2.1	3.0	2.8	3.5
Blood Red Count	0.1	0.7	2.6	-1.6	0.3	0.7	-1.4	-0.1	0.1	0.7	-0.7	-0.4	-0.7	0.9
Blood White Count	1.2	8.8	13.8	-1.2	2.9	3.7	3.0	3.4	2.6	3.4	2.7	2.6	3.5	2.8
Heel T-Score	0.6	4.5	20.3	-1.5	0.1	-2.9	-0.3	-1.4	-1.9	0.8	-2.8	-1.6	-4.5	-1.4
BMI	0.1	0.6	2.1	0.8	-0.5	-0.1	1.1	0.5	0.2	0.7	1.2	1.4	-0.6	-0.1
Height	0.6	12.4	53.6	5.3	-3.8	2.8	-2.4	-1.4	0.2	-4.5	1.5	0.3	7.3	-1.3
Waist Hip Ratio (WHR)	1.3	6.0	14.7	-2.9	3.8	2.0	2.0	2.7	1.8	3.6	0.8	1.2	-0.1	3.0
Systolic Blood Pressure	0.5	2.6	10.0	-2.2	3.2	1.3	0.5	1.2	0.8	2.7	0.1	0.7	0.0	1.5
Smoking Status	4.9	11.8	19.4	-3.0	3.1	2.5	4.0	4.3	3.7	4.4	3.0	3.3	1.6	3.8
Allergy or Eczema	0.4	1.0	4.8	-2.2	0.2	-0.3	-1.0	0.1	0.4	-0.1	-1.4	0.7	-1.5	-0.1
Cardiovascular Disease	1.6	5.2	12.8	-2.8	3.6	3.0	1.9	2.3	1.3	3.2	0.7	0.4	-1.3	2.2
Hypothyroidism (self reported)	0.8	1.8	3.8	-0.1	1.3	1.9	1.0	1.4	1.7	1.0	1.9	0.7	1.4	1.3
Respiratory disease	0.9	2.1	4.9	-2.2	1.7	1.0	1.4	1.4	1.6	2.0	0.3	0.8	-0.1	1.8
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.5	-1.0	0.3	0.7	0.7	0.9	0.4	1.2	0.2	0.6	0.1	0.8
Lung FEV1/FVC ratio	0.5	2.6	7.2	0.3	1.0	0.9	0.6	1.3	1.6	0.8	2.7	2.5	2.2	1.6
Lung FVC	0.4	2.3	5.2	-1.8	-1.4	-2.3	-0.0	-0.8	-0.7	0.4	-2.1	-1.8	-2.1	-0.9
Neuroticism	0.7	1.8	5.0	-1.4	0.9	-1.0	2.2	1.5	0.8	1.5	0.2	1.0	-1.9	0.7
Chronotype (morning person)	0.9	2.0	11.4	0.8	-2.1	1.0	0.3	-0.4	0.4	-1.9	-0.6	0.0	3.4	-0.6
Hair Pigment	0.1	1.5	4.8	-0.4	0.2	1.3	1.3	1.2	1.4	0.7	1.1	0.8	2.2	1.3
Tanning	0.1	0.7	2.6	0.9	0.1	-0.1	0.0	-0.9	-1.2	0.1	-0.3	-0.6	-1.0	-1.6
Hand grip strength (left)	1.7	4.5	7.8	0.9	-2.3	-2.4	-1.8	-2.6	-2.4	-2.3	-2.8	-1.9	0.1	-2.3
Number of treatments/medications taken	2.1	3.8	8.2	-2.4	2.1	2.2	2.5	2.2	1.4	2.9	0.8	0.8	-0.9	2.0
Average weekly spirits intake	1.1	1.3	3.5	1.9	0.6	1.9	-0.2	0.1	-0.1	-0.7	1.6	0.9	1.7	0.7
Sensitivity / hurt feelings	0.6	1.1	4.2	-0.2	-0.5	-1.3	0.3	-0.5	-0.9	-0.3	-1.1	-1.7	-2.0	-0.6
Frequency of depressed mood in last 2 weeks	1.2	1.6	5.3	-1.5	0.6	-0.7	2.0	1.5	1.2	2.3	0.5	0.7	-0.7	0.8
Hearing difficulty/problems: Yes	0.6	0.9	2.7	-0.7	-0.6	-1.3	-0.7	-0.5	-1.3	0.2	-1.3	-0.7	-1.7	-0.5
Relative age of first facial hair	2.4	4.9	8.5	1.8	-0.6	0.6	-2.8	-2.7	-2.9	-2.6	-2.9	-2.9	0.1	-1.9
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.3	-1.2	1.3	1.5	0.5	1.1	1.0	1.1	0.2	0.4	0.9	0.7
Ever used hormone-replacement therapy (HRT)	3.3	4.2	10.5	-1.9	1.9	1.0	3.2	2.3	1.4	3.2	1.9	1.4	-0.6	2.0
Ever had hysterectomy (womb removed)	0.5	0.6	2.6	0.6	-0.6	-1.6	-0.7	-0.4	-1.1	-0.4	-0.4	0.2	-0.9	-0.5
Systolic blood pressure, automated reading	0.5	1.4	4.5	-0.7	1.9	1.0	0.7	1.0	0.9	2.1	1.0	1.2	-0.1	1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.1	-1.8	0.8	-0.7	1.0	1.1	0.5	1.1	0.0	1.1	-0.6	0.7
Angina	1.0	1.3	3.5	-1.6	0.9	1.5	0.8	0.5	-0.6	1.9	-1.1	0.4	-1.3	0.0
Medication for hormone replacement therapy	4.4	4.9	12.0	-0.8	1.0	1.4	3.5	2.7	2.3	2.5	2.9	2.2	0.7	2.6
Vitamin and mineral supplements	2.2	3.0	5.8	1.2	-1.6	0.6	-1.7	-2.1	-2.2	-1.5	-2.0	-2.2	0.2	-2.4
Supplements: Zinc	0.7	0.8	1.7	-1.1	1.3	-0.4	0.5	1.1	0.4	0.8	0.4	1.2	-0.7	0.9
Medication: Co-codamol	0.2	0.2	0.9	-0.7	0.5	-0.9	0.0	0.1	0.2	0.5	-0.2	0.0	0.2	0.0
Medication: Metformin	0.1	0.1	0.4	-0.0	-0.6	-0.6	-0.3	0.4	-0.1	-0.1	-0.5	0.3	0.3	-0.1
Diabetes (father)	0.7	0.9	1.9	-0.8	-0.5	-1.4	-1.2	-0.7	-0.8	-0.0	-1.0	-0.5	-1.4	-1.0
Diabetes (mother)	0.7	1.0	3.0	-0.1	1.0	0.4	0.8	0.7	0.9	0.7	1.1	0.5	1.7	1.5
Severe depression (siblings)	0.5	0.6	3.3	-0.6	0.4	0.5	1.8	0.9	0.3	1.0	0.3	0.3	0.1	0.5
Pack years adult smoking proportion	2.0	3.0	5.0	-1.7	1.2	-0.7	1.7	1.9	2.0	2.0	1.7	2.2	-1.2	2.0
Impedance of leg (right)	0.1	0.5	1.4	0.2	1.2	-0.3	0.8	0.5	0.7	1.0	0.8	0.5	0.7	0.5
Leg fat-free mass (left)	0.2	1.3	3.6	1.5	-1.9	0.8	-1.2	-0.8	-0.4	-1.8	-0.1	-0.6	1.3	-0.7
Trunk fat percentage	0.2	0.7	2.2	-0.1	0.2	0.4	1.3	0.8	0.8	1.5	0.6	1.0	-0.8	-0.0
Hand grip strength (right)	1.5	4.2	7.3	1.0	-2.1	-1.5	-1.7	-2.7	-2.0	-2.5	-2.7	-2.1	0.6	-2.4
Townsend deprivation index at recruitment	3.5	4.9	12.0	-3.1	2.4	1.0	2.5	2.3	2.4	3.5	0.8	1.5	-0.8	1.9
Current tobacco smoking	6.3	10.4	19.2	-3.1	3.4	1.4	3.4	3.8	3.6	4.4	2.8	3.3	1.0	3.6
Average weekly fortified wine intake	0.4	0.5	1.9	1.0	-0.8	-0.1	-1.4	-0.2	-0.0	-1.1	0.4	0.1	0.0	-0.1
Maternal smoking around birth	4.1	6.0	13.9	-1.7	2.8	0.7	3.7	2.9	2.5	3.3	2.0	1.8	0.4	2.8
Fed-up feelings	3.4	6.2	12.3	-3.5	2.5	-0.7	2.6	2.9	2.5	3.2	1.4	2.1	-1.7	2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	6.5	-1.6	1.4	0.1	2.5	2.0	1.3	2.5	1.1	1.3	-1.4	1.2
Relative age voice broke	1.0	1.6	4.7	-0.2	-0.5	-0.0	-1.3	-1.4	-1.5	-0.8	-2.2	-2.0	-0.3	-1.3
Taking other prescription medications	1.0	1.6	3.5	-1.8	0.5	1.8	1.9	1.4	1.0	1.4	0.2	0.5	-0.8	1.3
Age when periods started (menarche)	0.3	0.7	3.4	1.8	-0.9	0.3	0.5	-0.1	-0.1	-0.6	0.5	-0.1	1.6	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.2	0.8	0.1	0.0	0.5	0.5	0.4	-0.1	0.9	0.7	1.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.5	-0.0	-0.7	-1.2	-0.7	-0.4	0.0	0.4	-0.4	-0.3	-0.4	-0.1
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	5.2	-0.5	0.9	1.4	2.3	1.9	1.9	1.2	1.8	1.1	1.2	1.5
Qualifications: CSEs or equivalent	0.9	1.2	2.9	-0.2	0.8	-0.0	1.7	1.5	1.3	1.1	1.2	1.1	0.7	1.2
Serious illness, injury or assault to yourself	0.3	0.4	1.7	0.0	0.4	1.3	-0.5	-0.3	-0.6	-0.4	-0.2	-1.1	0.6	-0.4
High blood pressure	0.6	1.7	6.7	-0.8	1.9	2.6	0.6	0.4	-0.1	1.6	0.1	-1.1	-1.7	0.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.5	-1.6	0.5	-0.2	-1.1	0.1	0.4	-0.5	-1.0	1.1	-0.7	0.3
Multivitamins +/- minerals	1.9	2.4	4.0	-1.0	1.4	-0.0	1.7	1.9	1.7	1.5	2.0	1.8	-0.7	1.9
Stomach or abdominal pain in last month	0.5	0.6	1.5	-0.3	0.2	-0.6	1.0	0.7	0.5	0.9	1.2	1.1	-0.5	0.7
Supplements: Glucosamine	1.7	2.2	8.4	-2.9	-0.4	1.4	2.1	1.4	1.0	2.4	-0.6	0.3	-0.4	0.6
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.2	-0.3	-0.7	-0.8	-0.8	-0.9	-1.6	-0.1	-1.2	-0.4	-1.8	-1.0
Medication: Atenolol	1.3	1.6	4.4	0.0	0.4	1.5	-1.3	-1.4	-1.4	-0.6	-1.6	-2.1	-0.7	-1.4
Medication: Levothyroxine sodium	0.2	0.3	1.0	0.7	0.3	0.0	0.1	0.5	0.2	0.6	1.0	-0.5	0.9	0.4
Sitting height	0.9	6.4	15.4	2.6	-3.9	0.4	-3.4	-2.0	-0.9	-3.9	-0.6	-1.4	3.5	-1.3
Chronic bronchitis/emphysema (father)	1.2	1.4	4.3	-1.0	0.3	-0.6	2.1	1.1	1.3	1.2	1.1	1.4	-1.1	0.9
High blood pressure (mother)	1.2	1.6	4.4	-2.1	1.1	-0.4	0.6	1.0	0.2	2.0	-0.1	-1.2	-1.8	1.6
Body mass index (BMI)	0.2	1.1	2.6	-0.4	0.3	-0.0	1.4	1.0	0.9	1.3	1.2	1.6	-1.1	0.8
Impedance of leg (left)	0.3	1.3	3.2	-0.8	1.7	0.0	1.5	1.2	1.3	1.8	0.8	0.8	0.2	0.9
Leg predicted mass (left)	0.3	1.4	3.9	1.5	-2.0	0.7	-1.3	-0.9	-0.5	-1.8	-0.2	-0.7	1.2	-0.8
Trunk fat mass	0.1	0.4	1.0	0.3	-0.5	0.4	1.0	0.6	0.8	0.9	0.7	1.0	-0.2	-0.1
Waist circumference	0.2	0.7	2.0	-0.2	0.5	1.0	1.0	0.9	0.8	1.4	0.7	1.1	-0.4	0.4
Number of incorrect matches in round	1.1	1.7	4.9	-1.6	1.5	-0.0	2.0	1.0	0.6	1.9	0.4	-0.1	-2.2	0.7
Past tobacco smoking	0.7	1.4	5.0	0.4	-0.3	-1.1	-2.2	-1.4	-1.0	-1.3	-1.2	-1.2	-0.6	-0.7
Alcohol usually taken with meals	0.3	0.4	1.0	0.7	-0.0	-0.2	-0.8	-0.9	-1.0	-0.9	-0.4	-0.4	0.1	-0.6
Nervous feelings	0.5	0.9	5.1	1.2	-0.4	-2.3	-0.4	-0.3	-0.6	-1.4	0.2	0.1	-0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	6.5	-0.7	1.4	-0.8	2.0	1.1	0.7	2.5	1.0	0.6	-1.1	0.9
Hearing difficulty/problems with background noise	0.7	1.1	4.0	-0.5	-0.2	-0.5	-0.8	-0.9	-1.3	-0.5	-2.0	-1.4	-0.9	-1.1
Hair/balding pattern: Pattern 2	3.0	3.8	6.5	-1.7	2.4	1.3	1.9	2.4	2.5	1.5	1.8	1.5	1.1	2.5
Had menopause	0.4	0.5	2.1	0.2	0.2	1.4	0.7	0.6	0.3	1.2	0.8	0.6	0.4	0.2
Had other major operations	0.2	0.2	0.9	-0.3	-0.7	-0.3	0.2	0.2	-0.4	-0.1	-0.6	-0.6	-0.9	-0.0
Forced vital capacity (FVC)	0.3	1.0	2.9	-0.4	-1.7	-0.8	-0.7	-0.9	0.0	-1.1	-1.5	-0.9	0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.5	0.0	-0.5	-0.7	0.0	0.1	0.5	0.7	0.1	0.4	0.3	0.1
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.3	-1.9	1.2	-0.7	1.3	1.2	0.4	2.1	0.3	1.2	-1.4	1.0
Qualifications: None of the above	1.5	3.2	6.6	-1.4	1.8	0.5	2.1	1.8	1.7	2.6	1.8	2.3	-0.7	1.8
Financial difficulties in last 2 years	2.6	3.5	6.6	-2.4	1.4	1.0	2.1	2.6	2.5	1.8	1.3	1.7	0.4	2.3
Mouth/teeth dental problems	2.9	4.5	8.5	1.4	-1.9	-1.1	-2.9	-2.5	-1.7	-2.7	-2.2	-2.3	0.3	-2.7
Heart attack	0.8	1.0	3.0	-1.6	1.1	1.7	0.5	0.2	-0.1	1.5	-0.4	0.7	-1.0	0.4
Allergy	0.2	0.5	2.0	1.4	-0.1	-0.1	0.2	-0.3	-0.8	-0.0	0.4	-1.1	0.6	-0.6
Pain all over the body in last month	0.8	0.9	2.0	-0.6	1.2	1.4	1.4	1.0	0.7	0.9	0.9	0.3	-0.7	0.5
Diabetes (self-reported)	0.1	0.1	0.4	0.4	-0.1	-0.2	-0.1	-0.1	-0.6	0.1	0.3	-0.5	-0.3	0.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.1	0.2	-1.0	-1.1	-1.3	-1.3	-1.2	-1.8	-1.5	-0.6	-0.2	-0.9
Medication: Ramipril	0.7	0.9	4.9	-0.9	0.5	2.2	0.6	-0.0	-0.7	0.9	-0.8	-0.1	-1.1	-0.1
Medication: Simvastatin	1.1	1.5	3.3	-1.8	1.7	0.9	0.9	1.2	0.3	1.8	0.2	0.8	-1.8	0.8
Fluid intelligence score	2.3	4.8	8.7	1.8	-2.8	-1.2	-2.4	-2.4	-2.3	-3.0	-2.1	-1.4	0.3	-2.8
Illnesses of siblings	0.5	0.7	2.2	-0.7	-0.7	-1.5	0.3	0.5	1.3	0.2	0.7	0.1	0.4	1.2
Neuroticism score	0.7	1.4	4.2	-1.3	0.4	-1.3	2.0	1.2	0.6	1.3	0.3	0.6	-1.9	0.7
Weight	0.1	0.3	1.1	0.8	-1.1	0.4	0.1	0.1	0.3	-0.2	0.6	0.6	0.5	-0.2
Impedance of arm (right)	0.1	0.4	1.5	1.0	-0.1	0.6	-0.1	-0.4	-0.4	-0.2	-0.5	-0.9	0.6	-1.2
Arm fat percentage (right)	0.4	1.5	4.1	-0.3	0.6	0.6	2.0	1.2	1.1	1.8	1.3	1.8	-0.8	0.6
Trunk fat-free mass	0.3	1.7	5.3	1.8	-2.3	0.4	-1.0	-1.0	-0.4	-2.0	0.2	0.0	1.8	-0.5
Hip circumference	0.2	0.8	2.8	1.6	-1.7	0.0	-0.3	-0.6	-0.5	-0.8	0.2	0.1	-0.2	-1.4
Time employed in main current job	0.8	0.9	5.4	0.5	-1.2	0.5	-0.5	0.4	0.5	-0.9	0.3	1.1	2.3	0.4
Alcohol intake versus 10 years previously	0.5	0.7	3.1	-0.8	-0.3	-1.7	-0.1	-0.2	-0.0	0.1	-0.6	0.6	-1.8	-0.1
Father’s age at death	1.6	2.2	6.1	0.3	-2.5	0.0	-1.8	-1.6	-1.5	-1.4	-1.8	-1.2	-0.1	-1.7
Worrier / anxious feelings	0.2	0.4	1.6	-0.1	-0.1	-0.3	1.2	0.6	-0.4	0.3	0.4	0.6	-1.3	-0.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	5.2	-1.4	1.2	0.3	2.3	1.7	0.5	2.3	0.9	1.2	-1.5	0.6
Falls in the last year	2.0	2.7	7.3	-1.2	1.8	2.7	2.1	1.8	1.5	2.1	1.0	1.0	0.7	1.1
Hair/balding pattern: Pattern 3	2.6	3.9	10.4	0.1	-1.0	-2.0	-1.1	-2.1	-2.7	0.0	-2.1	-0.6	-3.2	-3.1
Number of live births	0.2	0.3	1.9	-0.1	0.8	-0.3	-0.5	0.2	-0.6	0.3	-0.3	-0.2	-1.4	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.2	-0.4	-1.3	-0.4	-0.2	-0.4	0.7	-1.1	-0.8	-0.3	1.5	-0.1
Pulse rate	0.7	1.1	2.9	0.1	0.7	1.3	1.0	1.2	1.0	0.7	1.1	0.2	1.7	1.3
Happiness	0.7	0.9	3.5	-1.5	0.8	-0.4	0.9	0.3	-0.3	1.9	-0.4	0.5	-1.3	-0.3
Noisy workplace	2.0	2.5	5.3	-2.0	0.6	0.5	2.2	2.1	1.9	2.3	0.6	1.6	0.2	1.4
Qualifications: A levels/AS levels or equivalent	2.1	4.7	11.8	-1.0	-1.4	-0.7	-2.4	-2.2	-1.9	-1.4	-3.4	-3.0	-2.3	-2.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.0	0.1	-0.4	-0.5	-1.3	-1.4	-0.9	-1.1	-1.3	-1.2	-1.3	-0.6
Mouth/teeth dental problems: Dentures	1.2	2.1	6.1	-1.9	1.6	-1.0	0.9	1.2	0.5	2.5	0.5	0.7	-1.8	1.8
Asthma	0.4	0.7	2.4	-1.5	0.4	-0.2	1.2	0.3	0.5	1.5	-0.3	-0.0	-1.0	0.4
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	6.1	-1.0	1.6	-0.3	1.9	2.1	1.9	0.8	1.6	2.5	0.2	2.2
Medication: Cholesterol lowering	0.4	0.6	4.1	-0.1	0.7	2.0	-0.1	-0.1	-0.7	1.0	-0.1	-0.4	-0.7	-0.3
Depression (self-reported)	0.2	0.2	1.0	-1.0	0.6	-0.4	0.3	0.1	0.4	0.4	-0.0	0.6	-0.7	0.1
Medication: Lansoprazole	0.3	0.3	0.9	0.8	-0.2	0.9	-0.3	0.0	-0.0	-0.3	0.9	0.1	-0.1	1.0
Prospective memory result	1.6	1.9	3.9	0.5	2.0	1.8	1.1	1.1	1.3	0.3	2.0	1.6	1.5	1.1
Lung cancer (father)	0.7	0.9	3.6	1.9	-0.0	-0.1	0.5	0.4	0.1	-0.7	1.6	1.1	0.9	0.6
Illnesses of mother	0.8	1.0	3.8	1.3	-1.9	0.0	-0.4	-0.9	-0.5	-1.1	-0.3	-0.6	0.8	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	4.4	-0.7	-1.2	-0.2	0.0	0.1	1.0	-0.8	-0.5	-0.0	2.1	0.4
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	0.9	-0.8	0.1	-0.0	0.0	0.0	0.8	0.8	0.2	1.0	0.6
Impedance of arm (left)	0.3	1.2	4.0	1.1	-0.7	-0.4	-0.7	-1.0	-1.1	-0.7	-1.2	-1.7	0.2	-2.0
Arm fat mass (right)	0.2	1.0	2.6	0.1	0.1	0.3	1.5	1.0	1.0	1.2	1.3	1.6	-0.3	0.6
Trunk predicted mass	0.3	1.6	5.0	1.8	-2.2	0.4	-1.0	-1.0	-0.4	-2.0	0.1	-0.0	1.7	-0.5
Standing height	0.6	5.6	11.0	2.7	-3.2	1.0	-2.8	-1.9	-1.2	-3.1	-1.1	-2.0	3.3	-2.0
Length of working week for main job	0.1	0.1	0.2	0.2	0.5	-0.0	-0.4	-0.2	0.1	0.2	-0.0	-0.3	0.3	0.1
Exposure to tobacco smoke at home	0.3	0.4	1.7	-0.2	1.3	0.4	-0.2	0.9	0.5	0.2	0.6	0.1	0.1	0.7
Breastfed as a baby	0.7	0.8	2.0	1.0	0.3	0.1	-1.2	-1.0	-1.4	-1.2	-0.4	-0.5	0.3	-1.2
Tense / ‘highly strung’	1.9	3.2	5.9	-2.1	2.2	-0.1	2.4	2.3	1.7	2.2	1.1	1.8	-0.9	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	-0.8	0.1	1.0	1.2	0.5	-0.6	1.0	-0.2	-0.4	-1.2	-0.2
Hair/balding pattern: Pattern 4	1.3	3.3	10.2	-3.2	-0.9	-1.9	1.9	1.0	0.8	2.3	-0.5	1.2	-2.9	-0.6
Birth weight of first child	1.4	2.6	5.3	1.9	-1.9	-1.1	-1.7	-1.6	-1.5	-2.3	-1.1	-0.9	-0.2	-2.3
Peak expiratory flow (PEF)	0.5	1.2	7.3	0.8	-0.5	0.6	0.1	-0.3	1.2	-1.6	0.5	0.4	2.7	0.6
Pulse wave reflection index	1.1	1.4	3.0	1.5	-1.6	-1.2	-1.7	-1.6	-1.4	-0.5	-0.5	-0.7	0.0	-0.5
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.8	-0.1	1.6	1.9	2.2	0.9	1.3	1.7	1.3	1.2	0.9	0.9
Loud music exposure frequency	0.5	0.6	2.2	-0.2	1.2	-0.6	0.9	0.6	0.6	1.5	0.3	0.7	0.3	0.2
Qualifications: O levels/GCSEs or equivalent	2.6	4.1	10.9	-0.4	-2.3	-0.8	-2.1	-2.0	-2.2	-1.3	-3.3	-2.6	-1.3	-2.2
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	6.9	-0.2	1.2	1.5	1.8	2.0	1.6	1.5	2.6	1.4	0.4	2.4
Blood clot in the leg (DVT)	1.3	1.7	3.5	1.8	-1.0	-0.5	-1.1	-1.9	-1.1	-1.7	-1.1	-1.2	-0.7	-1.7
Medication: Paracetamol	3.0	5.0	9.9	-2.1	2.1	0.2	3.2	3.0	2.3	2.4	2.0	2.4	0.2	2.5
Headache pain in last month	0.9	1.5	3.5	-1.1	1.0	0.1	1.7	1.9	0.8	1.5	1.2	0.8	-0.3	1.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	5.0	-0.1	-1.0	-2.2	-0.6	0.0	0.8	-0.8	0.2	0.7	1.0	0.5
Glaucoma (self-reported)	0.2	0.2	0.6	0.3	-0.6	0.4	-0.1	-0.5	-0.7	-0.4	-0.2	-0.8	-0.4	0.1
Gout (self-reported)	1.7	2.3	6.3	-2.5	1.4	0.7	2.0	1.8	0.9	2.2	-0.3	-0.3	-1.8	0.8
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.9	-0.4	1.1	0.9	0.5	1.2	1.2	1.3	1.4	0.3	0.7	1.0
Medication: Amlodipine	0.8	1.1	4.5	-0.5	2.1	2.0	0.2	0.7	0.0	1.5	0.3	-0.5	-0.1	0.8
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.6	-0.3	0.4	0.8	-0.0	0.2	0.2	-0.0	0.3	-0.1	0.4	0.3
Birth weight	0.8	1.8	7.2	0.6	-0.8	0.0	0.6	1.3	1.5	-0.7	1.7	2.7	1.8	1.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.0	-1.1	0.9	0.1	2.0	0.9	1.1	1.9	1.0	0.6	-0.5	1.6
High blood pressure (siblings)	0.5	0.7	3.5	-0.8	1.2	1.9	-0.1	0.8	0.3	0.5	0.1	0.8	0.4	0.9
Forced vital capacity (FVC), Best measure	0.3	1.0	3.6	-0.2	-1.9	-0.4	-0.5	-0.5	0.1	-1.3	-1.1	-0.9	1.9	-0.4
Body fat percentage	0.3	1.3	3.5	-0.4	0.6	0.3	1.7	1.1	1.2	1.9	1.1	1.6	-1.0	0.5
Leg fat percentage (right)	0.6	2.3	4.7	-0.2	1.0	-0.4	2.0	1.2	1.5	2.2	1.9	2.1	-1.3	1.1
Arm fat-free mass (right)	0.1	0.7	2.5	0.9	-1.6	0.4	-0.9	-0.6	-0.2	-1.3	0.0	-0.1	1.1	-0.3
Exposure to tobacco smoke outside home	1.4	1.9	5.1	-0.2	1.8	0.3	1.0	1.5	1.3	1.4	1.9	1.0	0.5	2.3
Comparative body size at age 10	1.0	2.8	6.3	0.4	-1.0	-2.5	-1.4	-2.0	-1.8	-0.9	-1.7	-0.9	-2.4	-2.0
Number of full brothers	3.9	4.9	8.3	-2.9	2.7	2.0	2.1	2.6	2.1	2.6	1.2	1.7	0.6	2.6
Worry too long after embarrassment	3.6	6.1	10.2	2.2	-3.0	-1.9	-1.5	-2.7	-2.7	-2.7	-2.0	-2.4	-2.2	-3.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.2	-1.1	0.3	1.1	1.7	1.1	0.7	2.1	1.1	0.8	-1.0	1.0
Wheeze or whistling in the chest in last year	2.7	4.8	11.1	-2.0	1.9	1.5	3.1	2.6	2.1	3.3	1.6	1.8	-0.2	2.3
Number of children fathered	0.7	0.8	1.8	0.3	-0.9	0.6	1.3	0.5	0.6	1.0	0.9	1.3	1.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	7.1	1.5	0.8	1.3	0.3	0.6	0.4	-0.7	1.4	1.2	2.7	-0.3
Age at first live birth	3.5	6.3	10.6	2.0	-3.3	-1.0	-3.1	-3.2	-2.7	-2.7	-2.5	-2.1	0.1	-2.8
Pulse wave peak to peak time	0.3	0.3	0.8	-0.9	0.9	0.1	0.0	0.1	0.1	-0.6	-0.7	-0.1	-0.7	-0.6
Health satisfaction	1.2	1.6	3.7	-1.4	1.9	0.9	1.9	1.2	0.1	1.9	-0.0	1.0	-1.0	0.0
Shortness of breath walking on level ground	1.5	1.8	4.1	-0.9	1.5	2.0	1.4	1.2	1.7	0.8	0.7	1.7	0.6	1.3
Qualifications: College or University degree	2.9	9.0	19.2	1.9	-2.5	-0.4	-3.6	-3.9	-3.5	-3.4	-3.3	-2.6	-0.4	-4.4
Eye problems/disorders: None of the above	0.2	0.3	1.8	0.3	-0.2	-0.3	0.3	0.4	0.5	-0.1	0.6	0.5	1.3	-0.0
Mouth/teeth dental problems: Loose teeth	0.9	1.0	5.1	1.0	0.2	2.3	0.0	0.4	0.7	-0.9	0.9	0.4	1.5	0.5
Emphysema/chronic bronchitis	3.2	3.6	6.2	-1.6	1.7	0.3	2.0	2.5	2.1	1.8	2.0	2.5	1.4	2.1
Medication for pain relief, constipation, heartburn	4.3	7.3	12.1	2.1	-2.8	-1.9	-3.4	-3.5	-2.5	-3.1	-2.3	-3.1	0.1	-3.1
Neck or shoulder pain in last month	0.7	1.0	2.7	-0.8	1.1	1.1	1.1	1.3	0.6	1.1	0.8	0.2	-0.1	1.7
Medication: Blood pressure	0.9	1.5	6.6	-0.9	2.0	2.6	1.1	0.4	-0.1	1.4	-0.3	-0.4	-1.2	0.1
Angina (self-reported)	1.0	1.3	3.2	-1.7	0.9	1.7	0.7	0.2	-0.7	1.8	-1.4	0.2	-1.5	-0.1
Migraine (self-reported)	0.2	0.2	0.8	-0.1	-0.1	-0.4	-0.3	-0.5	-0.7	-0.0	-0.6	-0.4	-0.9	-0.4
Medication: Ibuprofen	1.8	2.1	4.7	-1.5	1.7	-0.4	1.5	2.0	1.5	0.8	1.0	1.7	0.0	2.2
Medication: Allopurinol	2.6	3.4	7.8	-2.7	2.1	0.8	2.0	2.2	1.7	2.8	0.1	0.8	-1.7	1.4
Medication: Omeprazole	3.3	3.9	9.9	-1.4	3.1	2.5	1.9	2.0	1.2	2.6	1.3	2.1	-0.1	1.7
Medication: Seretide 50 evohaler	0.6	0.7	2.0	-1.1	-0.2	-0.4	-0.8	-0.6	-0.5	0.5	-1.1	-1.4	-1.3	0.1
Mean time to correctly identify matches	1.0	1.8	11.7	-1.3	-0.4	-1.1	0.7	-0.0	-0.8	1.6	-0.7	-0.6	-3.4	-1.0
Heart disease (mother)	2.0	2.5	4.3	-1.5	1.5	1.1	2.1	1.8	1.7	1.7	1.1	2.1	0.2	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.9	-1.2	0.8	0.1	1.0	0.8	1.7	1.5	0.4	0.2	0.9	1.3
Whole body fat mass	0.2	0.7	1.8	0.2	-0.1	0.4	1.1	0.8	1.0	1.1	1.1	1.4	-0.2	0.3
Leg fat mass (right)	0.3	1.0	2.5	0.1	0.3	0.3	1.2	0.9	1.2	1.3	1.6	1.6	-0.4	0.7
Arm predicted mass (right)	0.1	0.6	1.9	0.9	-1.4	0.6	-0.7	-0.3	0.1	-1.2	0.3	0.2	1.2	-0.1
Pulse rate, automated reading	0.5	1.7	3.8	-0.3	1.6	1.9	1.2	1.3	1.3	1.4	1.0	-0.0	2.0	1.0
Alcohol intake frequency.	0.8	1.8	6.7	-2.3	0.1	-2.1	0.0	0.3	-0.2	1.0	-1.2	-0.5	-2.6	0.3
Comparative height size at age 10	0.8	4.3	8.2	1.0	-2.7	-1.5	-2.9	-2.5	-1.9	-1.7	-2.1	-2.9	0.0	-1.9
Number of full sisters	2.1	2.5	7.2	-0.8	1.7	0.4	2.7	2.3	1.6	1.5	1.2	1.0	1.1	1.8
Suffer from ‘nerves’	0.6	1.0	5.7	-0.3	0.8	-2.4	0.6	0.8	0.1	0.2	0.6	0.3	-1.7	0.6
Overall health rating	2.4	5.3	16.0	-2.0	2.1	0.8	3.4	2.5	1.4	4.0	1.3	2.6	-1.8	1.2
Chest pain or discomfort	2.9	4.1	8.4	-2.2	2.1	2.2	2.4	2.3	1.9	2.9	1.4	2.1	-0.2	1.7
Had major operations	0.9	1.0	3.3	0.0	-0.7	0.3	1.8	1.0	0.8	1.6	1.0	0.9	1.0	0.4
Age at last live birth	2.0	2.9	4.8	1.6	-2.0	-0.8	-1.8	-2.2	-2.1	-1.7	-1.8	-1.7	-0.5	-1.9
Family relationship satisfaction	1.2	1.5	4.5	-1.1	0.6	0.8	1.9	1.1	1.0	2.1	0.8	1.3	-0.2	1.2
Leg pain on walking	0.7	0.9	3.7	-0.4	0.4	0.8	1.9	1.0	0.6	1.3	0.9	1.0	-0.6	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	-0.8	0.6	0.1	0.0	0.6	0.6	0.4	0.2	0.5	-0.3	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	2.0	-1.0	0.9	1.4	-0.3	-0.1	0.0	0.2	-0.4	-0.7	-0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	1.1	-0.7	-1.1	-0.7	-0.4	-0.7	-0.2	0.1	-0.1	0.5	-0.8
Medication: Aspirin	2.6	3.5	9.5	-2.0	1.9	2.1	1.9	1.9	1.1	3.1	1.1	1.9	-0.5	1.8
Supplements: Vitamin C	0.9	1.1	2.5	-1.3	1.6	0.9	0.5	0.9	1.3	0.5	0.6	1.4	0.4	1.3
Knee pain experienced in last month	1.8	2.7	7.0	-1.6	1.6	1.8	2.6	1.7	1.7	1.8	1.0	1.8	-0.1	1.4
Hypertension (Self-reported)	0.7	1.9	6.9	-0.8	2.2	2.6	1.1	0.7	0.0	1.7	0.4	-0.7	-1.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.2	9.4	-1.2	2.4	3.1	1.4	2.0	1.1	1.8	1.6	1.4	-0.1	2.0
Illnesses of father: Heart disease	1.4	1.9	10.1	-3.2	1.2	-0.7	-1.0	0.2	-0.6	1.0	-2.1	-0.0	-1.4	-0.2
Illnesses of siblings: Diabetes	0.8	1.0	3.1	-1.6	1.4	0.1	0.4	0.9	0.2	1.4	-0.3	-0.1	-1.8	0.5
Smoking status: Previous	0.3	0.5	2.2	0.2	-0.5	1.1	1.5	0.7	0.4	0.3	0.5	0.6	0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.2	-1.5	-0.5	0.9	1.5	1.4	1.5	1.4	-0.0	-0.4	1.2	1.0
Whole body fat-free mass	0.3	1.4	4.3	1.6	-2.1	0.7	-1.1	-0.9	-0.4	-1.9	0.0	-0.2	1.6	-0.6
Leg fat-free mass (right)	0.2	1.3	3.6	1.2	-1.9	0.8	-1.3	-0.8	-0.5	-1.8	-0.4	-0.8	1.0	-0.8
Arm fat percentage (left)	0.2	0.9	2.8	-0.1	0.3	0.0	1.7	0.8	0.8	1.5	1.0	1.4	-1.1	0.2
Average weekly red wine intake	0.4	0.5	1.8	-0.4	-1.2	0.3	-0.2	-0.4	-0.7	-0.4	-1.4	-0.8	-0.5	-0.9
Handedness (chirality/laterality): Left-handed	0.6	0.8	3.1	1.6	-1.8	0.1	0.3	-0.8	-0.4	-1.2	0.5	0.1	-0.4	-0.4
Mood swings	0.6	1.1	3.4	-1.6	0.4	-0.9	1.2	0.7	-0.0	1.9	-0.5	0.3	-1.7	0.7
Loneliness, isolation	3.9	5.4	9.8	-2.4	1.4	1.1	3.1	3.1	2.8	3.0	2.0	2.2	-0.8	2.3
Long-standing illness, disability or infirmity	0.4	0.6	2.6	-0.2	1.0	1.6	0.1	-0.2	-1.0	0.4	-0.8	0.0	-1.0	-0.8
Ever had bowel cancer screening	1.4	1.7	4.2	0.4	-0.6	-1.0	-0.7	-1.3	-1.7	0.2	-1.6	-1.5	-1.6	-2.0
Diabetes diagnosed by doctor	0.4	0.7	2.2	-1.0	0.1	0.1	1.0	0.9	0.3	1.5	0.5	0.0	-0.8	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	5.0	-2.2	1.6	0.1	0.1	0.9	-0.3	1.8	-0.8	-1.0	-2.2	0.8
Friendships satisfaction	1.1	1.4	4.0	-1.0	0.9	0.1	1.7	1.5	0.8	1.7	0.4	2.0	0.5	0.6
Qualifications: nursing, teaching	2.9	4.5	10.6	-0.2	-0.3	-0.9	-2.9	-2.4	-2.2	-2.2	-3.2	-2.3	-1.4	-2.5
Commuting to job workplace: Walk	0.6	0.7	2.9	0.7	-0.9	-1.7	-0.5	-0.2	-1.1	-0.2	-0.4	-0.3	-0.9	-0.8
Eye problems/disorders: Cataract	0.3	0.3	0.7	0.3	0.6	0.9	-0.7	-0.5	-0.2	-0.6	-0.1	0.6	-0.8	-0.0
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	8.6	-1.5	1.4	0.5	2.9	2.0	1.9	2.2	1.6	2.1	-0.1	2.3
Medication for cholesterol	2.7	4.0	7.7	0.7	-1.8	-2.8	-2.7	-2.0	-1.7	-2.2	-2.4	-1.3	-0.6	-2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.6	-0.3	0.9	1.0	1.2	0.8	1.3	0.7	1.1	0.6	0.1	1.0
Back pain experienced in last month	1.1	1.6	3.8	-1.2	0.9	0.8	1.1	1.6	1.5	1.2	1.2	1.6	0.1	1.9
Mineral and other dietary supplements	1.1	1.5	6.2	2.5	0.1	0.4	-0.6	-0.4	0.4	-1.4	1.2	0.5	2.5	0.0
Breast cancer (self-reported)	0.3	0.3	1.3	-0.0	-0.6	-0.4	-1.1	-0.4	-0.1	-1.1	-0.8	-0.1	0.1	-0.1
Asthma (self-reported)	0.3	0.6	2.2	-1.4	0.1	-0.2	1.0	0.1	0.3	1.5	-0.6	-0.3	-1.0	0.1
Osteoporosis (self-reported)	0.8	1.0	3.6	-1.3	0.7	0.1	1.0	1.4	0.7	1.9	0.4	1.0	-0.3	0.6
Osteoarthritis (self-reported)	1.0	1.3	2.6	-0.3	-1.0	-0.4	-0.2	-1.2	-1.5	-0.8	-1.6	-1.3	-1.5	-1.5
Medication: Aspirin	2.8	3.7	10.7	-2.2	1.9	2.3	1.9	2.0	1.0	3.3	1.0	1.4	-0.8	1.7
Medication: Gliclazide	0.9	1.0	3.3	-1.3	-0.1	0.3	1.0	1.5	0.8	0.8	0.7	1.8	0.3	1.0
Illnesses of father: None of the above (group 1)	2.1	2.6	6.1	0.7	0.2	1.4	2.5	1.4	2.1	1.2	1.9	1.0	2.4	1.6
Smoking status: Current	6.0	9.6	17.1	-3.1	3.4	0.9	3.0	3.6	3.5	4.1	2.8	3.2	0.8	3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.5	-1.2	-1.0	0.1	0.5	0.1	0.2	0.3	-1.1	-0.2	0.2	-0.9
Whole body water mass	0.2	1.3	4.2	1.5	-2.0	0.7	-0.9	-0.7	-0.3	-1.8	0.1	-0.1	1.6	-0.5
Leg predicted mass (right)	0.3	1.4	3.8	1.2	-1.9	0.7	-1.4	-0.9	-0.6	-1.8	-0.5	-0.9	0.9	-0.9
Arm fat mass (left)	0.1	0.5	1.3	0.3	-0.2	0.0	1.1	0.6	0.6	0.8	0.9	1.1	-0.5	0.2
Number of self-reported non-cancer illnesses	1.0	1.8	8.6	-1.4	0.4	0.9	0.4	-0.0	-1.0	1.3	-1.4	-1.7	-2.9	-0.4
Average weekly champagne plus white wine intake	0.7	1.0	3.7	1.1	-0.5	0.6	-1.2	-0.5	-0.2	-1.2	-0.2	-1.9	1.2	-0.7
Miserableness	0.3	0.6	1.7	-0.5	-0.7	-0.3	1.2	0.1	-0.4	0.8	-0.5	-1.3	-1.1	0.0
Guilty feelings	0.8	1.2	6.8	0.0	-0.8	-0.8	2.6	0.8	0.8	1.2	1.3	1.0	-0.6	0.3
Wears glasses or contact lenses	1.2	1.3	2.9	-0.8	-1.4	1.0	-1.7	-0.8	-1.2	-1.1	-1.6	-0.9	-1.1	-0.5
Ever taken oral contraceptive pill	0.7	0.8	2.1	-1.5	1.4	0.4	-0.1	-0.1	-0.3	0.4	-1.2	-0.4	-1.4	-0.3
Hearing aid user	2.2	2.5	4.8	1.4	-1.5	-0.2	-1.4	-1.9	-2.2	-1.8	-1.6	-2.2	-0.5	-1.6
Mother’s age at death	0.4	0.5	1.7	0.7	1.3	1.1	0.1	0.2	0.1	-0.3	0.1	0.4	1.2	-0.0
Financial situation satisfaction	3.5	4.4	11.1	-3.3	1.0	0.4	2.9	2.5	2.1	3.2	0.6	1.4	-1.1	1.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.2	0.6	0.4	1.1	-0.1	-0.3	-0.4	0.0	-0.0	0.0	0.3	-0.3
Commuting to job workplace: Public transport	0.4	0.5	3.3	0.1	-0.9	-1.8	0.2	-0.3	0.4	0.0	0.2	-0.1	-0.5	0.6
Eye problems/disorders: Glaucoma	0.1	0.1	0.7	-0.1	-0.3	-0.4	0.8	0.2	-0.1	0.4	0.1	0.2	-0.5	0.3
Medication: Blood pressure	0.9	1.8	6.8	-0.9	1.6	2.6	1.0	1.1	0.7	1.8	1.2	-0.1	0.5	1.3
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.0	-1.6	-0.7	-0.6	1.5	1.2	1.7	1.0	0.1	0.5	-0.5	1.4
Supplements: Fish oil (including cod liver oil)	1.4	1.8	8.0	-1.4	-0.9	-1.4	-0.4	-0.4	-1.6	0.5	-1.5	-0.8	-2.8	-0.9
High cholesterol (Self-reported)	0.9	1.6	3.7	-1.8	1.9	1.9	0.0	0.9	0.7	1.6	0.2	0.8	-0.4	1.6
Medication: Bendroflumethiazide	0.3	0.5	2.2	1.5	0.1	1.1	-0.1	-0.5	-0.6	-0.2	0.8	-0.8	-0.1	-0.3
Medication: Paracetamol	2.9	4.5	8.1	-1.7	2.3	0.7	2.8	2.9	2.1	2.2	2.1	2.3	0.9	2.4
Medication: Lisinopril	0.9	1.2	3.2	-0.4	1.8	1.8	-0.6	-0.7	-0.7	0.5	-1.4	-1.7	-0.3	-0.6
Medication: Atorvastatin	0.4	0.5	2.0	0.8	-0.4	1.4	-0.2	-0.6	-0.9	0.3	-0.4	-0.6	0.5	-1.0
Illnesses of father: High blood pressure	0.5	0.6	1.4	-0.3	0.8	-0.8	-0.9	-0.7	-0.7	-0.6	-1.2	-0.8	-1.1	-0.6
Alcohol drinker status: Never	0.4	0.5	1.2	-0.2	-0.6	-0.3	0.5	0.7	1.0	0.8	1.0	0.5	0.5	1.1
Ever smoked	1.0	1.7	5.2	-0.1	0.3	0.1	2.3	1.3	1.2	1.5	1.6	1.9	1.1	0.8
Basal metabolic rate	0.2	0.9	3.1	1.4	-1.8	0.6	-0.6	-0.5	-0.1	-1.4	0.3	0.1	1.4	-0.4
Leg fat percentage (left)	0.9	3.1	6.7	-0.8	1.3	-0.0	2.5	1.7	1.8	2.6	1.9	2.3	-1.6	1.3
Arm fat-free mass (left)	0.1	0.6	1.8	0.8	-1.0	0.9	-0.2	0.0	0.4	-0.8	0.6	0.7	1.3	0.3
Number of operations (self-reported)	0.5	0.7	2.0	-0.2	-1.2	-0.6	1.1	1.4	0.6	1.0	0.8	0.2	0.1	0.7
Average weekly beer plus cider intake	1.8	2.6	7.5	0.1	1.3	2.7	0.7	1.3	1.8	0.7	1.9	1.5	2.0	1.9
Irritability	2.9	4.9	14.4	-2.7	2.0	0.3	3.3	2.4	1.5	3.8	0.9	0.5	-2.1	1.8
Risk taking	0.7	1.1	3.3	-0.2	1.3	1.7	1.8	0.9	0.9	0.9	1.0	0.5	0.4	0.5
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.7	-0.9	0.7	1.5	1.5	1.6	1.2	1.5	1.0	0.9	0.7	1.0
Fractured/broken bones in last 5 years	1.3	1.7	7.1	-2.1	1.2	-0.0	0.1	-0.3	-1.2	1.0	-1.7	-0.7	-2.7	-0.4
Age started oral contraceptive pill	4.4	5.5	10.6	1.6	-2.6	-0.9	-2.6	-3.2	-2.4	-2.1	-2.6	-2.3	-0.3	-3.2
Diastolic blood pressure, automated reading	0.2	0.6	3.5	-0.4	1.9	0.9	0.2	0.3	0.3	0.9	-0.0	0.2	-0.6	0.5
Ever depressed for a whole week	1.1	1.3	5.0	-2.2	-0.1	-0.3	1.1	1.1	0.6	1.4	0.2	0.4	-1.1	1.7
Unable to work because of sickness or disability	0.8	1.1	2.3	-0.0	1.5	0.2	1.2	1.0	1.2	1.4	1.4	0.4	-0.4	1.2
Commuting to job workplace: Cycle	0.4	0.5	1.6	0.9	-0.5	-0.9	0.5	0.4	0.6	0.1	0.9	0.6	1.3	0.2
Myopia	1.1	1.5	3.9	0.4	-1.6	-0.0	-1.1	-1.3	-1.1	-1.5	-1.4	-2.0	-1.2	-0.6
Vascular/heart problems diagnosed by doctor	0.5	1.4	6.6	0.3	-1.7	-2.6	-0.6	-0.2	0.4	-1.5	-0.2	0.7	1.5	-0.2
Cholesterol lowering medication	1.7	2.5	5.8	-1.9	1.7	0.9	1.7	1.9	1.2	2.4	1.0	1.2	-0.7	1.9
Medication: Omeprazole (e.g. Zanprol)	2.9	3.6	9.7	-1.6	2.6	3.1	2.1	1.8	0.8	2.7	0.7	1.5	0.0	1.6
Pain experienced in last month	1.7	2.9	5.4	2.0	-1.7	-1.2	-2.3	-2.2	-1.4	-2.2	-1.1	-1.1	0.9	-1.8
Supplements: Calcium	0.7	0.8	4.9	-2.2	0.2	-0.3	0.3	0.8	0.1	0.9	-0.9	0.7	-0.6	0.3
Basal cell carcinoma (self-reported)	3.5	4.2	7.2	-0.8	0.6	2.1	2.6	2.7	2.3	2.4	2.6	2.1	-0.1	2.1
Heart attack/myocardial infarction (self-reported)	0.7	1.0	3.2	-1.6	1.0	1.8	0.3	0.1	-0.1	1.4	-0.5	0.6	-0.9	0.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.5	1.5	-0.7	-0.2	-1.0	-1.6	-1.1	-1.6	-1.0	-1.1	-0.6	-1.5
Heart disease (siblings)	0.2	0.2	0.7	0.5	0.6	0.5	0.4	-0.1	-0.8	-0.2	-0.3	-0.3	0.6	-0.5
Alcohol drinker status: Previous	0.9	1.0	4.4	-2.1	1.5	1.1	0.2	0.9	0.6	0.4	-0.6	0.5	0.5	0.8
Pack years of smoking	1.9	2.8	6.2	-1.5	1.3	-0.5	1.6	1.8	1.8	1.9	1.7	2.5	-1.0	2.0
Impedance of whole body	0.0	0.2	0.5	0.2	0.7	0.1	0.2	0.1	0.1	0.5	-0.3	-0.7	0.5	-0.7
Leg fat mass (left)	0.3	1.2	2.6	-0.2	0.3	0.4	1.4	1.1	1.3	1.5	1.5	1.6	-0.7	0.7
Arm predicted mass (left)	0.1	0.5	1.6	0.8	-1.2	1.0	-0.1	-0.0	0.4	-0.7	0.5	0.4	1.3	0.2