Hub : Genes

RAB3GAP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.2060	0.0730	1.0e-03	0.005	NA	-0.004	NA	-0.001	1.3e-01	NA	9.2e-01	NA	4.1e-01
2	GTEx	Skin Sun Exposed Lower leg	0.0450	0.0250	7.0e-03	0.003	NA	0.001	NA	0.001	1.8e-01	NA	2.3e-01	NA	2.7e-01
3	YFS	Blood	0.0868	0.0245	1.1e-16	0.062	0.057	0.056	0.062	0.064	1.7e-19	3.7e-18	1.3e-17	1.3e-19	3.3e-20
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0247	0.0182	5.6e-03	0.011	0.015	0.010	NA	0.008	2.0e-02	6.5e-03	2.5e-02	NA	3.9e-02
5	TCGA	Lung Adenocarcinoma	0.0409	0.0265	7.4e-03	0.008	0.010	0.008	NA	0.012	3.5e-02	2.0e-02	3.1e-02	NA	1.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.8	2.8	5.3	2.0	-1.7	-0.9	-2.3	-1.0
Bipolar Disorder or Schizophrenia	1.3	3.1	4.8	1.3	-2.2	0.1	-2.2	-2.1
Depressed Affect (Nagel 2018)	0.2	0.5	2.2	-1.5	-0.3	0.1	-0.2	-0.4
Depression (Nagel 2018)	0.7	1.1	1.6	-1.3	0.9	1.1	1.1	0.7
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.8	-1.7	-0.7	-1.0	-1.7	-0.5
Neuroticism (Nagel 2018)	0.2	0.4	1.5	-1.2	-0.2	0.4	-0.4	-0.5
Schizophrenia (2018)	0.7	1.4	3.5	-0.1	-1.4	0.9	-1.0	-1.9
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	-1.0	-0.7	0.6	-0.4	-0.7
Worry (Nagel 2018)	0.3	0.7	2.9	-1.7	0.7	0.2	0.1	0.4
Alzheimer’s Disease (in mother)	0.9	1.0	2.3	1.2	1.0	0.2	1.5	0.5
Alzheimer’s Disease (in father)	1.2	1.3	2.1	-1.0	-1.5	-0.7	-1.3	-1.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	0.6	-0.5	-0.4	-0.2	-0.7
Crohns Disease (2017)	0.5	1.0	2.6	-1.6	-0.7	1.0	-0.3	-0.9
Irritable Bowel Disease (IBD)	0.2	0.6	1.3	-1.1	0.1	1.1	0.6	-0.3
Ulcerative Colitis (UC)	0.3	0.6	1.1	-0.2	1.0	1.1	1.1	0.2
Major Depression (MDD)	0.1	0.1	0.2	-0.4	0.0	0.4	-0.5	0.3
Reaction Time	0.7	1.3	3.7	-1.1	-0.1	1.9	1.2	-0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.5	-1.2	-0.5	-0.6	-1.0	-0.1
Breast Cancer	0.1	0.2	0.8	0.2	-0.9	-0.1	0.4	-0.0
Ovarian Cancer	0.1	0.1	0.3	0.2	-0.3	0.3	0.1	-0.5
Prostate Cancer	0.4	0.5	1.5	0.6	-1.2	-0.1	-0.8	-0.1
Age at First Birth	0.4	0.6	1.8	-0.3	0.7	-1.4	0.4	0.4
Bipolar Disorder (2011)	1.7	1.6	3.8	0.6	-1.2	-1.9	-1.6	-0.3
Body Mass Index (BMI) (2010)	0.4	0.6	2.6	-0.3	0.1	1.6	0.6	-0.2
Coronary Artery Disease (CAD)	0.4	0.4	1.4	1.2	0.1	0.9	0.0	-0.2
Crohns Disease (2012)	0.2	0.3	1.0	-0.3	1.0	0.4	0.6	0.2
Mean Putamen Volume	0.4	0.5	1.3	-0.2	0.0	-1.0	-1.1	0.0
Fasting Glucose	1.3	1.6	3.2	0.6	-1.8	0.8	-0.9	-1.7
HbA1C	2.1	2.4	4.0	1.0	1.6	-0.7	2.0	1.9
HDL Cholesterol	1.1	1.8	3.2	1.5	-1.0	-1.2	-1.8	-1.0
LDL Cholesterol	0.6	0.9	1.7	0.6	0.3	0.9	1.2	-1.3
Lupus	1.5	2.3	4.8	-1.3	1.5	0.3	2.2	1.6
Neuroticism (2016)	0.2	0.3	0.9	-1.0	-0.4	0.4	-0.4	0.2
Primary Biliary Cirrhosis	1.4	1.9	6.0	-1.1	0.7	-2.5	-0.0	1.4
Rheumatoid Arthritis	0.7	0.9	3.0	-0.8	-0.3	1.7	0.1	-1.0
Schizophrenia (2014)	0.9	1.9	3.3	1.3	-1.4	0.4	-1.7	-1.8
Triglycerides	0.2	0.4	0.9	-0.9	0.0	-1.0	-0.2	0.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.5	1.9	-0.2	-0.5	-0.7	-0.3
Ulcerative Colitis	1.9	2.7	5.9	-1.2	2.0	1.3	2.4	0.7
Blood Eosinophil Count	0.1	1.1	4.0	2.0	-0.3	-0.5	0.0	-1.1
Blood Platelet Count	0.0	0.4	1.2	0.4	0.0	1.1	-0.4	-0.7
Blood Red Count	0.9	8.3	23.2	-4.8	1.7	1.1	2.8	2.5
Blood White Count	0.2	1.4	5.5	-0.3	0.1	-2.4	-0.5	0.9
Heel T-Score	0.1	0.9	2.2	0.5	-0.9	-1.5	-1.1	0.3
BMI	0.4	2.1	8.6	-2.9	-1.2	-0.2	-0.3	0.6
Height	1.8	35.6	60.4	1.9	7.6	-1.6	7.8	7.4
Waist Hip Ratio (WHR)	0.5	2.4	4.8	2.2	1.4	-1.3	1.0	1.6
Systolic Blood Pressure	1.3	6.6	24.0	-4.9	-1.8	-0.8	-1.4	-1.8
Smoking Status	1.5	3.6	5.1	1.8	2.2	0.0	2.3	2.2
Allergy or Eczema	0.6	1.6	3.2	-0.2	-1.7	0.0	-1.4	-1.8
Cardiovascular Disease	0.5	1.7	4.8	-1.6	-0.2	-2.2	-0.9	0.6
Hypothyroidism (self reported)	0.2	0.4	1.0	-0.0	-1.0	-0.1	-0.3	-1.0
Respiratory disease	0.6	1.4	2.5	-1.6	-0.8	-1.5	-0.6	-1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.8	1.4	0.1	-0.4	-0.2	-0.6
Lung FEV1/FVC ratio	0.4	2.1	6.2	0.7	-1.1	2.5	-0.5	-1.6
Lung FVC	1.5	7.5	12.7	2.5	-2.1	-2.1	-3.6	-3.1
Neuroticism	0.4	1.0	3.3	-0.5	-0.0	-1.8	-1.0	0.5
Chronotype (morning person)	1.5	3.4	8.7	-3.0	-2.4	0.0	-1.2	-0.9
Hair Pigment	0.2	5.3	10.4	1.0	-2.4	-0.2	-3.1	-3.2
Tanning	0.1	0.9	3.0	1.7	0.5	0.1	1.0	0.4
Hand grip strength (left)	1.7	4.5	19.1	4.4	0.6	0.9	0.4	-1.5
Number of treatments/medications taken	0.8	1.4	5.1	-2.3	-0.2	-1.2	0.4	0.6
Average weekly spirits intake	1.0	1.2	2.6	-0.8	-1.6	-0.3	-1.0	-1.3
Sensitivity / hurt feelings	0.8	1.3	4.4	0.8	-1.0	0.2	-2.1	-0.8
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.4	1.2	0.9	0.1	0.8	0.6
Hearing difficulty/problems: Yes	0.1	0.1	0.5	0.2	0.4	-0.1	-0.7	0.3
Relative age of first facial hair	0.9	1.8	7.3	2.7	0.6	0.4	1.0	0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.2	1.5	0.1	-0.0	-0.4	-0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.1	-0.5	-1.1	-1.4	-0.7	0.2
Ever had hysterectomy (womb removed)	2.1	2.4	7.6	-0.4	1.2	0.9	2.8	1.4
Systolic blood pressure, automated reading	1.9	5.6	19.9	-4.5	-1.9	0.3	-1.4	-1.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	0.3	-0.9	-0.7	-0.3	-0.6
Angina	0.7	0.9	2.6	-1.1	0.0	-1.6	-0.2	0.9
Medication for hormone replacement therapy	1.4	1.6	3.4	0.8	-1.1	-1.6	-1.8	-0.5
Vitamin and mineral supplements	0.1	0.1	0.6	-0.8	-0.4	-0.1	0.0	-0.1
Supplements: Zinc	1.9	2.1	3.9	1.8	2.0	1.0	1.2	0.9
Medication: Co-codamol	0.8	0.9	2.8	0.5	0.7	0.9	1.7	0.5
Medication: Metformin	0.5	0.8	3.1	-0.5	-0.2	-1.8	-0.4	0.5
Diabetes (father)	1.3	1.6	3.8	0.4	-1.2	0.0	-1.9	-1.6
Diabetes (mother)	0.2	0.3	0.8	-0.9	-0.4	-0.3	-0.6	-0.1
Severe depression (siblings)	0.6	0.7	2.2	1.5	-0.1	-0.1	-1.2	-0.3
Pack years adult smoking proportion	0.6	1.0	2.5	0.0	1.5	-0.4	-0.2	1.6
Impedance of leg (right)	0.4	1.7	4.9	0.9	0.5	2.2	1.3	-1.0
Leg fat-free mass (left)	0.9	4.7	10.8	-1.1	2.2	-1.9	1.8	3.3
Trunk fat percentage	1.2	5.0	11.7	-3.4	0.9	0.7	2.3	2.6
Hand grip strength (right)	1.3	3.5	14.3	3.8	-0.0	0.7	0.1	-1.6
Townsend deprivation index at recruitment	0.9	1.2	2.3	1.0	-1.0	-1.4	-1.5	-0.0
Current tobacco smoking	0.5	0.9	3.4	1.8	0.4	-0.1	0.4	0.8
Average weekly fortified wine intake	0.8	0.9	1.6	-0.3	0.9	-1.2	0.8	1.1
Maternal smoking around birth	0.3	0.5	1.4	-0.6	0.5	0.6	1.2	-0.2
Fed-up feelings	0.2	0.3	0.7	-0.0	-0.4	-0.3	-0.8	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-1.1	-0.8	0.2	-0.5	-0.3
Relative age voice broke	0.9	1.4	3.2	1.8	0.4	1.5	1.3	0.2
Taking other prescription medications	1.0	1.6	3.5	-0.9	-1.9	-1.0	-1.3	-1.1
Age when periods started (menarche)	0.2	0.4	0.9	0.7	0.5	0.9	0.5	0.2
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.3	-2.1	0.4	1.1	2.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.1	-0.3	1.1	0.0	1.3	1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.1	0.8	1.0	-0.2	1.0	0.8
Qualifications: CSEs or equivalent	0.4	0.5	1.1	0.8	-1.1	0.1	0.1	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.2	1.1	-0.4	-0.1	-1.0	-0.0
High blood pressure	0.9	2.4	9.8	-3.1	0.3	-1.1	0.5	1.0
Hayfever, allergic rhinitis or eczema	1.2	2.6	5.8	0.8	-1.9	0.0	-1.6	-2.4
Multivitamins +/- minerals	0.2	0.2	0.7	0.8	0.5	-0.1	0.1	0.3
Stomach or abdominal pain in last month	0.9	1.1	2.4	-0.4	0.3	-1.5	1.4	0.9
Supplements: Glucosamine	0.6	0.8	1.9	-1.4	-0.4	-1.1	-0.6	0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.1	-0.1	0.2	0.0	0.1
Medication: Atenolol	2.4	3.0	5.3	-1.0	1.5	-1.3	2.3	2.1
Medication: Levothyroxine sodium	0.5	0.8	1.8	0.6	-1.3	-0.3	-0.8	-1.0
Sitting height	0.5	3.5	8.5	0.1	2.9	-1.0	1.6	2.3
Chronic bronchitis/emphysema (father)	0.4	0.4	2.0	-1.4	0.1	0.0	-0.3	-0.2
High blood pressure (mother)	0.3	0.5	1.9	-1.4	0.3	-0.3	0.5	0.0
Body mass index (BMI)	0.6	2.6	11.3	-3.4	-0.3	0.3	0.4	1.2
Impedance of leg (left)	0.4	2.1	6.5	0.5	0.6	2.5	1.6	-1.0
Leg predicted mass (left)	0.9	4.7	10.8	-1.1	2.2	-1.9	1.8	3.3
Trunk fat mass	1.4	5.9	10.1	-3.2	1.6	0.3	2.6	3.1
Waist circumference	0.7	2.5	7.7	-2.8	0.5	-0.2	1.2	1.7
Number of incorrect matches in round	1.9	3.2	5.2	1.8	-1.6	-0.2	-2.3	-2.2
Past tobacco smoking	1.3	2.3	7.2	-2.7	-1.3	-0.3	-1.0	-1.2
Alcohol usually taken with meals	0.7	1.1	3.6	0.9	-0.4	-0.3	-1.9	-0.9
Nervous feelings	0.2	0.3	1.3	-0.4	0.2	1.1	-0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.3	-0.3	2.1	-0.3	1.3	1.8
Hearing difficulty/problems with background noise	0.3	0.5	1.3	-0.7	-0.1	-0.9	-1.1	-0.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	-0.6	0.0	0.5	-0.1	-0.4
Had menopause	1.3	1.6	4.3	0.7	-1.3	-0.1	-2.1	-1.2
Had other major operations	1.0	1.2	3.2	0.1	-0.6	-1.8	-1.3	0.7
Forced vital capacity (FVC)	0.5	1.8	5.3	2.3	1.2	-1.2	0.9	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.4	-0.1	1.2	-0.8	0.1	1.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.2	-1.5	-0.1	-0.3	-0.4	-0.1
Qualifications: None of the above	0.4	0.9	3.1	-0.9	-0.8	1.8	-0.1	-0.3
Financial difficulties in last 2 years	0.9	1.2	3.1	-0.6	0.8	-1.7	0.7	1.1
Mouth/teeth dental problems	2.6	4.0	9.7	2.4	-0.6	-3.1	-2.0	-0.3
Heart attack	1.3	1.7	3.7	-1.6	0.3	-1.9	0.5	1.4
Allergy	1.0	2.4	4.9	0.3	2.2	1.0	1.4	1.9
Pain all over the body in last month	1.2	1.3	3.8	-1.1	0.3	-1.9	-0.3	1.2
Diabetes (self-reported)	0.2	0.4	0.7	0.9	0.7	-0.7	0.2	0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-0.2	0.8	-1.0	0.0	0.4
Medication: Ramipril	0.6	0.7	2.9	-1.7	-0.2	0.2	-0.7	-0.2
Medication: Simvastatin	0.9	1.3	5.4	-0.6	0.2	-2.3	-0.0	0.9
Fluid intelligence score	0.2	0.5	1.5	-0.7	-0.1	-1.2	-0.7	-0.0
Illnesses of siblings	1.5	2.1	6.4	2.5	1.3	-0.8	0.5	1.2
Neuroticism score	0.2	0.5	1.2	-0.2	0.6	-1.1	-0.3	0.8
Weight	1.1	5.2	9.3	-2.3	2.1	-0.1	2.7	3.1
Impedance of arm (right)	0.5	2.2	3.4	1.5	1.8	-0.3	1.7	1.5
Arm fat percentage (right)	0.9	3.5	11.0	-3.3	0.5	-0.1	1.1	2.2
Trunk fat-free mass	0.7	3.7	6.8	-0.0	2.6	-1.0	2.1	2.6
Hip circumference	0.7	2.9	10.2	-3.2	0.4	-0.4	1.1	1.7
Time employed in main current job	1.8	2.1	4.5	0.9	1.7	-1.2	0.8	2.1
Alcohol intake versus 10 years previously	0.2	0.4	1.6	-0.2	-0.3	1.2	0.2	0.1
Father’s age at death	0.4	0.5	1.4	-0.6	-0.9	0.1	0.1	-1.2
Worrier / anxious feelings	0.3	0.6	2.1	-1.4	0.6	-0.3	-0.5	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	4.0	-1.1	2.0	-1.1	1.5	2.0
Falls in the last year	1.5	2.1	3.5	-0.3	1.5	-1.7	1.2	1.9
Hair/balding pattern: Pattern 3	0.6	0.9	3.9	-2.0	-0.6	0.2	0.2	-0.3
Number of live births	1.3	1.9	4.5	-1.2	1.1	0.2	2.1	1.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	5.7	2.4	0.8	-0.3	0.5	-0.7
Pulse rate	1.1	1.8	3.6	-1.2	1.4	0.9	1.9	1.1
Happiness	0.6	0.7	1.3	-0.6	1.0	-1.1	0.6	0.9
Noisy workplace	0.5	0.7	1.9	-0.4	0.6	0.4	1.4	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	-1.2	0.8	-0.5	-0.5	0.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.9	1.0	-1.7	-0.0	-1.1	-1.5
Mouth/teeth dental problems: Dentures	1.2	2.0	3.4	-1.7	0.8	1.4	1.9	1.0
Asthma	0.7	1.3	2.8	-1.5	-0.9	-1.7	-0.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.1	1.8	0.5	-0.8	0.1	0.3
Medication: Cholesterol lowering	2.0	3.1	10.1	-0.8	-1.3	-3.2	-1.8	0.1
Depression (self-reported)	0.5	0.6	1.7	0.4	1.0	0.1	1.3	0.6
Medication: Lansoprazole	0.7	0.8	3.2	-0.0	-0.6	-0.4	-1.8	-0.5
Prospective memory result	0.4	0.5	0.9	0.6	-0.6	0.9	0.5	-0.9
Lung cancer (father)	0.3	0.4	0.9	0.4	0.4	0.5	1.0	0.7
Illnesses of mother	0.7	0.9	2.0	1.4	0.6	1.3	0.5	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.7	1.9	0.9	-0.1	-0.1	-0.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	-0.9	-1.2	0.4	-0.7	-0.6
Impedance of arm (left)	0.3	1.2	1.6	1.3	1.1	-0.4	1.3	1.1
Arm fat mass (right)	1.0	4.2	8.7	-3.0	1.2	-0.2	1.7	2.8
Trunk predicted mass	0.7	3.8	7.0	0.0	2.6	-1.0	2.1	2.5
Standing height	1.6	16.3	27.7	2.0	5.3	-0.9	5.3	4.6
Length of working week for main job	1.4	1.6	4.7	2.2	1.2	-0.1	0.9	0.9
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.8	-0.2	0.5	0.6	-0.5
Breastfed as a baby	1.2	1.5	3.1	1.0	-1.0	1.6	-0.2	-1.8
Tense / ‘highly strung’	0.4	0.6	1.4	-0.4	0.8	-0.9	-0.2	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.4	-0.6	0.4	0.5	0.3	0.5
Hair/balding pattern: Pattern 4	0.3	0.7	2.2	0.9	-0.2	-1.5	-0.6	0.3
Birth weight of first child	1.6	2.8	4.8	1.6	2.2	0.7	2.1	1.3
Peak expiratory flow (PEF)	0.3	0.7	2.1	1.0	-0.4	0.5	-0.5	-1.4
Pulse wave reflection index	1.4	1.7	4.0	0.4	-1.4	2.0	-0.4	-1.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.5	0.7	1.1	-0.4	1.6	0.8
Loud music exposure frequency	0.9	1.0	2.0	1.4	0.7	-1.0	-0.1	1.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.6	-0.3	0.4	-1.9	-1.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.9	0.7	0.8	1.4	-0.0	-0.4
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.1	0.2	0.4	0.7	0.6
Medication: Paracetamol	0.8	1.3	2.9	-0.4	1.7	-1.0	1.0	1.2
Headache pain in last month	0.8	1.3	5.1	-2.2	-0.8	-0.9	-0.1	0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	4.3	1.4	0.4	2.1	0.5	-0.6
Glaucoma (self-reported)	0.7	0.8	2.6	-0.2	0.2	1.2	1.6	0.1
Gout (self-reported)	0.4	0.6	1.8	1.4	-0.4	0.2	-0.7	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.6	1.2	0.1	-0.8	0.3	0.2
Medication: Amlodipine	0.7	1.0	3.8	-2.0	-0.7	-0.2	-0.6	-0.6
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.1	-0.8	-1.4	-1.2	-0.9	-0.9
Birth weight	1.8	3.8	5.3	2.0	2.1	-1.8	1.4	2.3
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	-0.6	-0.2	0.7	0.6	-0.5
High blood pressure (siblings)	2.8	4.0	14.2	-3.8	-1.7	1.0	0.0	-1.4
Forced vital capacity (FVC), Best measure	0.3	1.2	3.8	1.9	1.3	-0.6	0.3	-0.1
Body fat percentage	1.2	4.5	13.9	-3.7	0.4	1.0	1.9	2.0
Leg fat percentage (right)	1.1	4.0	16.2	-4.0	-0.3	1.1	1.2	1.0
Arm fat-free mass (right)	0.6	3.2	6.2	-1.2	2.1	-0.5	2.0	2.5
Exposure to tobacco smoke outside home	1.6	2.2	3.2	-0.5	-1.8	1.3	-1.6	-1.8
Comparative body size at age 10	0.7	2.0	4.2	2.1	1.1	-1.6	-0.8	1.1
Number of full brothers	0.5	0.6	1.4	-0.2	-0.7	-1.1	-1.2	-0.2
Worry too long after embarrassment	0.3	0.5	1.3	0.5	-0.5	-1.1	-0.7	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.8	0.2	1.0	0.6	-0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.6	0.5	0.1	0.5	0.3
Number of children fathered	1.9	2.1	4.0	-0.9	1.2	2.0	2.0	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.8	0.0	-0.4	-0.9	-0.1	-0.2
Age at first live birth	0.6	1.1	2.8	-0.5	-0.8	1.3	-0.0	-1.7
Pulse wave peak to peak time	1.1	1.3	2.7	1.0	1.6	-0.4	1.2	1.0
Health satisfaction	0.2	0.3	0.7	-0.8	0.2	-0.4	0.3	0.6
Shortness of breath walking on level ground	0.8	1.0	2.1	-0.4	0.9	0.6	1.5	1.2
Qualifications: College or University degree	0.1	0.3	0.5	-0.6	0.1	0.5	0.7	-0.6
Eye problems/disorders: None of the above	0.5	0.6	1.2	0.7	1.1	1.0	0.1	0.3
Mouth/teeth dental problems: Loose teeth	2.0	2.4	5.2	-0.6	-1.1	2.3	-0.1	-2.3
Emphysema/chronic bronchitis	1.2	1.4	2.5	-1.6	-1.3	0.0	-0.9	-1.4
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	-0.4	-1.1	0.6	-1.1	-0.9
Neck or shoulder pain in last month	0.7	1.0	2.6	-1.6	-0.8	-1.1	-0.6	0.0
Medication: Blood pressure	1.0	1.7	4.0	-2.0	0.4	-1.5	0.9	1.1
Angina (self-reported)	0.8	1.1	3.0	-1.1	0.1	-1.7	0.0	1.1
Migraine (self-reported)	0.5	0.6	2.5	-0.3	0.5	0.5	1.6	0.2
Medication: Ibuprofen	1.0	1.2	4.6	2.1	0.9	-0.3	0.7	0.4
Medication: Allopurinol	0.3	0.5	1.0	1.0	-0.2	0.6	-0.5	-0.8
Medication: Omeprazole	0.1	0.1	0.6	0.0	-0.2	-0.8	-0.2	0.1
Medication: Seretide 50 evohaler	0.8	0.9	2.3	-1.5	-0.4	0.6	-0.0	-1.2
Mean time to correctly identify matches	1.5	2.9	7.8	-2.0	-0.6	2.8	1.3	-1.0
Heart disease (mother)	1.0	1.2	2.0	-0.8	-1.3	-1.2	-1.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	4.3	0.5	0.9	-2.1	0.8	0.9
Whole body fat mass	1.1	4.7	11.0	-3.3	1.1	0.4	2.1	2.6
Leg fat mass (right)	1.1	4.1	12.9	-3.6	0.7	0.4	1.7	2.0
Arm predicted mass (right)	0.7	3.7	7.0	-1.1	2.3	-0.7	2.1	2.6
Pulse rate, automated reading	0.5	1.5	5.5	-2.4	-0.1	0.9	-0.0	1.0
Alcohol intake frequency.	0.1	0.3	0.8	-0.9	-0.2	0.1	0.6	0.7
Comparative height size at age 10	1.9	10.4	20.1	0.3	4.5	-1.6	3.4	4.2
Number of full sisters	0.3	0.4	1.1	-1.1	0.6	0.6	0.3	0.5
Suffer from ‘nerves’	0.2	0.3	0.7	-0.9	-0.4	-0.2	-0.7	-0.4
Overall health rating	0.6	1.4	4.8	-2.2	-0.7	-1.1	0.0	0.4
Chest pain or discomfort	0.4	0.6	1.4	-0.0	0.6	-1.1	0.1	1.2
Had major operations	0.5	0.6	1.5	0.6	0.2	-1.2	-0.6	0.7
Age at last live birth	0.6	0.8	1.7	-0.2	-0.9	1.2	0.5	-1.3
Family relationship satisfaction	0.4	0.5	1.5	-0.1	0.7	0.7	1.2	0.5
Leg pain on walking	0.9	1.1	2.7	-1.6	-0.8	1.0	0.3	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	0.7	-0.1	0.3	0.1	0.2
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.7	-1.6	0.6	1.2	1.2	0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.5	-1.0	0.3	0.9	1.2	-0.3
Medication: Aspirin	0.6	0.8	1.4	-0.8	0.6	-1.0	0.7	1.2
Supplements: Vitamin C	3.2	3.7	10.4	1.3	-0.4	3.2	-0.4	-2.5
Knee pain experienced in last month	1.7	2.6	4.1	-2.0	-1.6	1.5	0.4	-1.9
Hypertension (Self-reported)	0.7	2.0	8.6	-2.9	-0.0	-1.0	0.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.7	0.4	0.1	-0.4	-0.8	0.0
Illnesses of father: Heart disease	1.1	1.6	3.8	-0.8	1.1	0.4	1.9	1.5
Illnesses of siblings: Diabetes	0.3	0.4	0.6	0.8	-0.2	0.7	0.0	-0.7
Smoking status: Previous	0.8	1.2	3.0	1.7	1.1	-0.2	0.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	5.8	0.3	2.3	0.2	2.4	1.8
Whole body fat-free mass	0.7	3.9	7.8	-0.5	2.4	-1.2	2.0	2.8
Leg fat-free mass (right)	0.9	4.6	10.4	-0.8	2.2	-2.0	1.8	3.2
Arm fat percentage (left)	0.9	3.5	12.6	-3.5	0.1	-0.2	0.9	2.0
Average weekly red wine intake	0.3	0.5	1.3	-1.2	-0.4	-0.9	-0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.6	0.5	-0.2	-1.3	-0.7	0.3
Mood swings	0.0	0.0	0.1	-0.3	-0.0	-0.1	-0.0	0.1
Loneliness, isolation	1.3	1.9	3.6	-1.3	-1.9	1.2	-0.3	-1.5
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.7	-0.3	-0.7	-0.8	-0.2
Ever had bowel cancer screening	0.6	0.7	1.2	-0.9	-1.1	1.0	0.1	-0.6
Diabetes diagnosed by doctor	0.2	0.3	1.1	1.1	0.3	-0.5	-0.2	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	4.3	-0.2	1.4	-1.6	2.1	1.5
Friendships satisfaction	0.4	0.4	1.3	0.4	-0.1	-1.1	-0.7	0.5
Qualifications: nursing, teaching	0.9	1.4	3.6	0.9	-0.4	0.5	-1.9	-1.5
Commuting to job workplace: Walk	1.4	1.6	4.9	0.4	-0.9	-2.2	-1.4	0.0
Eye problems/disorders: Cataract	2.1	2.4	6.5	-1.2	0.7	-2.5	1.0	1.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.0	-1.4	1.0	0.7	1.2	1.3
Medication for cholesterol	1.0	1.6	3.2	1.0	1.3	0.8	1.8	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.2	2.0	-0.1	1.1	0.1	-1.0
Back pain experienced in last month	0.4	0.6	1.6	-1.2	-0.1	-1.2	0.2	0.4
Mineral and other dietary supplements	0.6	0.8	1.5	1.2	0.8	0.1	1.2	0.8
Breast cancer (self-reported)	0.7	0.8	2.4	-1.5	-0.0	-1.0	-0.3	0.8
Asthma (self-reported)	0.6	1.1	3.4	-1.4	-0.5	-1.8	0.0	-0.4
Osteoporosis (self-reported)	0.4	0.4	1.5	-0.3	0.5	-1.2	0.0	0.6
Osteoarthritis (self-reported)	2.6	3.4	7.1	-2.7	-2.4	-0.8	-1.6	-1.0
Medication: Aspirin	0.7	0.9	1.8	-0.5	0.8	-1.0	0.8	1.3
Medication: Gliclazide	0.7	0.8	1.3	0.8	1.1	-0.7	0.4	1.1
Illnesses of father: None of the above (group 1)	2.2	2.7	7.2	2.7	1.6	-0.7	1.0	1.5
Smoking status: Current	0.7	1.0	3.2	1.8	0.6	0.2	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.3	1.5	0.7	-0.0	0.5	-0.2
Whole body water mass	0.7	4.2	8.5	-0.4	2.5	-1.3	2.0	2.9
Leg predicted mass (right)	0.9	4.7	10.8	-0.8	2.2	-2.0	1.8	3.3
Arm fat mass (left)	1.0	4.2	9.3	-3.0	1.1	-0.2	1.7	2.7
Number of self-reported non-cancer illnesses	1.2	2.1	8.2	-2.9	-1.0	-0.5	-0.3	-0.9
Average weekly champagne plus white wine intake	1.3	1.8	7.0	2.6	1.0	-0.1	0.7	0.7
Miserableness	0.5	0.9	2.5	-0.9	0.0	-1.6	-1.0	0.2
Guilty feelings	0.6	0.8	2.4	1.5	1.1	0.1	0.5	0.6
Wears glasses or contact lenses	0.2	0.3	1.1	0.1	-0.4	-1.0	-0.4	-0.1
Ever taken oral contraceptive pill	0.6	0.7	3.2	1.8	0.3	0.2	0.4	0.2
Hearing aid user	0.3	0.4	0.8	-0.7	-0.4	0.9	-0.5	-0.4
Mother’s age at death	0.4	0.4	0.6	-0.7	-0.6	-0.8	-0.8	0.4
Financial situation satisfaction	0.4	0.5	2.0	-0.2	0.0	-1.4	0.2	0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.1	0.6	-0.0	-0.2	-0.0
Commuting to job workplace: Public transport	0.5	0.6	1.6	0.3	0.8	-1.2	0.4	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.6	-0.6	-0.1	0.7	1.3	0.4
Medication: Blood pressure	0.7	1.4	4.4	-2.1	-1.0	0.6	-0.7	-0.9
Pain type(s) experienced in last month: Hip pain	1.2	1.6	4.1	-1.4	-0.5	2.0	0.9	-0.9
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.6	0.2	-0.3	-0.4	0.0
High cholesterol (Self-reported)	1.7	3.0	7.8	0.2	-1.3	-2.8	-2.3	-0.6
Medication: Bendroflumethiazide	1.1	1.7	3.9	-2.0	0.5	-1.1	0.9	1.4
Medication: Paracetamol	0.8	1.3	3.0	0.8	1.7	0.2	1.4	0.9
Medication: Lisinopril	0.3	0.3	0.6	-0.8	0.7	0.2	0.7	0.2
Medication: Atorvastatin	0.8	1.0	1.7	-0.1	-1.2	-1.3	-1.2	-0.8
Illnesses of father: High blood pressure	1.1	1.4	2.4	-0.7	-1.3	0.2	-1.5	-1.6
Alcohol drinker status: Never	0.4	0.5	1.5	-1.2	-0.4	0.6	0.8	-0.1
Ever smoked	1.9	3.3	13.1	3.6	1.2	0.6	0.8	0.9
Basal metabolic rate	0.9	4.9	10.0	-0.9	2.6	-1.2	2.4	3.2
Leg fat percentage (left)	1.2	4.4	18.0	-4.2	-0.4	1.3	1.2	1.0
Arm fat-free mass (left)	0.7	3.7	6.7	-1.0	2.4	-0.4	2.2	2.6
Number of operations (self-reported)	0.9	1.4	4.1	0.9	0.1	-2.0	-0.7	1.2
Average weekly beer plus cider intake	0.6	0.9	2.8	-0.8	0.3	-1.7	-0.8	0.7
Irritability	0.3	0.5	0.9	-0.8	0.8	-0.3	0.5	1.0
Risk taking	2.3	3.4	8.9	3.0	1.9	0.4	1.3	1.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.5	-0.1	0.4	0.8	1.6	0.3
Fractured/broken bones in last 5 years	0.1	0.2	0.6	-0.2	0.2	-0.8	-0.3	0.2
Age started oral contraceptive pill	1.7	2.1	6.8	-2.6	-0.4	1.3	1.3	-0.3
Diastolic blood pressure, automated reading	1.3	4.0	16.4	-4.0	-1.3	0.6	-0.9	-0.6
Ever depressed for a whole week	0.9	1.1	3.6	0.6	-0.2	-1.9	-1.1	-0.2
Unable to work because of sickness or disability	1.2	1.6	4.4	0.5	-1.3	-1.2	-2.1	-0.4
Commuting to job workplace: Cycle	2.4	2.9	11.9	0.4	0.3	-3.5	-0.7	1.3
Myopia	0.8	1.2	2.1	0.7	-1.2	-1.0	-1.4	-1.1
Vascular/heart problems diagnosed by doctor	0.9	2.3	9.3	3.0	-0.0	1.3	-0.3	-0.9
Cholesterol lowering medication	1.1	1.7	3.3	-0.1	-1.8	-0.8	-1.4	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.3	-0.9	-0.5	-0.8	-0.5
Pain experienced in last month	0.7	1.1	4.0	2.0	0.7	1.0	-0.2	-0.1
Supplements: Calcium	0.6	0.7	1.4	0.5	-0.5	-0.6	-1.2	-1.1
Basal cell carcinoma (self-reported)	0.8	1.0	3.1	0.5	-0.3	1.1	0.3	-1.8
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.2	-1.6	0.1	-2.1	0.2	1.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	-0.1	0.1	0.3	0.6	0.4
Heart disease (siblings)	1.0	1.2	2.1	0.4	-1.0	1.1	-1.2	-1.4
Alcohol drinker status: Previous	0.8	0.9	2.7	-1.6	-0.1	-1.1	0.1	0.8
Pack years of smoking	0.5	0.7	1.9	-0.4	1.3	-0.2	-0.1	1.4
Impedance of whole body	0.3	1.3	3.4	1.0	0.9	1.2	1.9	0.2
Leg fat mass (left)	1.2	4.5	15.4	-3.9	0.5	0.6	1.7	1.9
Arm predicted mass (left)	0.8	4.2	8.4	-0.6	2.7	-0.7	2.2	2.9