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chr1:50,735,395-54,432,522

Best TWAS P=1.96e-52 · Best GWAS P=1.87e-61 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SCP2	0.08	0.05	bslmm	490	0.04	2.3e-05	6.8	-6.0	2.3e-09	-0.02	0.05	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TTC39A	0.05	0.04	enet	8	0.02	2.7e-03	5.2	-6.2	5.0e-10	-0.56	0.43	0.30	TRUE
3	CommonMind	Brain Pre-frontal Cortex	ZYG11B	0.04	0.04	lasso	4	0.04	3.0e-05	6.7	6.5	6.5e-11	0.02	0.45	0.55	FALSE
4	GTEx	Adipose Visceral Omentum	HIGD1AP11	0.21	0.03	lasso	6	0.02	2.1e-02	-4.2	-5.8	5.1e-09	-0.01	0.07	0.47	FALSE
5	GTEx	Brain Frontal Cortex BA9	RP11-334A14.2	0.26	-0.01	enet	20	0.00	2.9e-01	5.4	-6.2	5.3e-10	-0.04	0.06	0.21	FALSE
6	GTEx	Brain Hippocampus	RP11-334A14.2	0.43	-0.01	lasso	5	0.00	4.2e-01	-6.3	-6.9	4.2e-12	-0.01	0.05	0.07	TRUE
7	GTEx	Brain Hypothalamus	RP11-334A14.2	0.36	0.22	lasso	5	0.13	7.2e-04	-6.3	-6.1	9.0e-10	-0.01	0.08	0.12	TRUE
8	GTEx	Brain Nucleus accumbens basal ganglia	ZYG11B	0.17	-0.01	lasso	7	0.05	1.6e-02	7.2	5.8	5.9e-09	0.03	0.07	0.40	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	RP11-334A14.2	0.31	0.12	lasso	4	0.09	2.2e-03	-6.3	-6.3	3.0e-10	0.00	0.09	0.09	FALSE
10	GTEx	Breast Mammary Tissue (Female)	RP11-155O18.6	0.14	0.02	lasso	4	0.07	4.0e-03	3.0	5.3	1.2e-07	0.16	0.06	0.18	TRUE
11	GTEx	Cells EBV-transformed lymphocytes	SCP2	0.38	0.25	enet	16	0.24	2.9e-08	6.9	-6.2	4.1e-10	-0.03	0.06	0.94	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	TUBBP10	0.21	0.21	lasso	6	0.18	1.4e-06	6.8	-6.3	2.3e-10	-0.06	0.07	0.91	FALSE
13	GTEx	Cells Transformed fibroblasts	ZYG11B	0.38	0.02	enet	52	0.20	1.2e-14	4.6	8.1	5.2e-16	0.01	0.18	0.29	TRUE
14	GTEx	Esophagus Gastroesophageal Junction	CDKN2C	0.14	0.11	enet	17	0.12	3.0e-05	15.9	-15.2	2.0e-52	-0.85	0.02	0.91	TRUE
15	GTEx	Esophagus Muscularis	HIGD1AP11	0.16	0.01	lasso	7	0.02	1.3e-02	-4.2	-5.9	3.9e-09	-0.02	0.04	0.81	FALSE
16	GTEx	Esophagus Muscularis	RP4-657D16.3	0.06	0.05	lasso	4	0.03	9.8e-03	4.6	-5.4	7.6e-08	-0.12	0.17	0.26	FALSE
17	GTEx	Lung	GPX7	0.41	0.35	enet	23	0.35	1.8e-27	3.9	5.2	2.7e-07	-0.01	1.00	0.00	TRUE
18	GTEx	Lung	ECHDC2	0.13	0.11	enet	10	0.10	4.1e-08	-3.8	-5.8	9.0e-09	0.00	1.00	0.00	FALSE
19	GTEx	Lung	HIGD1AP11	0.13	0.02	lasso	5	0.02	2.2e-02	-4.2	-5.8	5.5e-09	-0.02	0.08	0.51	TRUE
20	GTEx	Skin Not Sun Exposed Suprapubic	TXNDC12	0.12	0.01	enet	12	0.03	1.2e-02	-3.7	6.6	4.3e-11	0.06	0.04	0.44	TRUE
21	GTEx	Skin Not Sun Exposed Suprapubic	ZYG11B	0.17	0.09	lasso	2	0.12	6.4e-07	6.9	6.5	5.9e-11	0.04	0.14	0.85	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	HIGD1AP11	0.19	0.16	lasso	3	0.14	7.9e-08	5.2	-5.5	4.5e-08	0.01	0.57	0.40	FALSE
23	GTEx	Spleen	ECHDC2	0.43	0.01	enet	8	0.00	4.1e-01	-6.5	-6.8	1.1e-11	0.01	0.08	0.10	TRUE
24	GTEx	Whole Blood	ECHDC2	0.09	0.09	lasso	5	0.08	1.9e-07	6.7	-6.9	4.0e-12	-0.06	0.07	0.93	FALSE
25	GTEx	Whole Blood	TUBBP10	0.10	0.07	lasso	2	0.08	1.5e-07	6.7	-7.0	3.4e-12	-0.06	0.09	0.91	TRUE
26	NTR	Blood	ECHDC2	0.03	0.04	lasso	2	0.04	1.9e-12	6.8	-7.0	3.4e-12	-0.06	0.05	0.95	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	TTC39A	0.10	0.02	bslmm	199	0.04	3.5e-06	1.9	-5.5	4.8e-08	-0.37	0.81	0.01	TRUE
28	ROSMAP	Brain Pre-frontal Cortex	ZYG11B	0.12	0.16	lasso	4	0.15	3.2e-19	6.9	6.6	3.8e-11	0.04	0.12	0.88	FALSE
29	YFS	Blood	ECHDC2	0.32	0.23	lasso	10	0.33	3.5e-112	6.8	-7.9	2.5e-15	-0.02	0.15	0.85	TRUE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	ZYG11B	0.20	0.14	enet	9	0.16	1.6e-05	7.3	7.2	8.6e-13	0.04	0.01	0.98	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GLIS1	0.10	0.05	enet	9	0.04	2.2e-03	7.0	6.0	2.5e-09	0.00	0.12	0.47	TRUE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ZYG11A	0.08	0.04	blup	37	0.05	2.9e-04	-3.8	-5.9	3.8e-09	0.02	0.03	0.19	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SCP2	0.15	0.00	blup	92	0.03	2.5e-02	-6.4	-7.7	1.5e-14	-0.01	0.03	0.60	TRUE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZYG11B	0.03	0.02	enet	6	0.02	1.1e-03	6.9	6.2	6.5e-10	0.01	0.02	0.95	FALSE
35	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GPX7	0.21	0.16	blup	46	0.13	1.9e-05	3.9	5.2	1.9e-07	-0.03	0.27	0.21	TRUE
36	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PODN	0.22	0.01	blup	94	0.06	3.3e-03	2.0	-9.2	2.7e-20	0.02	0.01	0.48	TRUE
37	The Cancer Genome Atlas	Thyroid Carcinoma	ZYG11A	0.04	0.03	lasso	3	0.02	1.7e-03	7.3	-7.2	4.2e-13	-0.02	0.00	0.99	FALSE