TWAS hub - PODN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1086	0.0326	7.4e-05	0.030	0.033	0.059	0.051	0.059	7.7e-05	3.9e-05	4.6e-08	3.4e-07	4.5e-08
2	YFS	Blood	0.0184	0.0085	6.9e-03	-0.001	0.006	0.002	0.006	0.001	6.1e-01	3.5e-03	7.3e-02	3.0e-03	9.2e-02
3	TCGA	Lung Adenocarcinoma	0.0925	0.0340	4.4e-06	0.002	0.042	0.034	NA	0.013	1.9e-01	1.0e-05	7.1e-05	NA	1.0e-02
4	TCGA	Testicular Germ Cell Tumors	0.2230	0.0960	2.7e-03	0.010	0.062	0.041	NA	0.013	1.3e-01	3.3e-03	1.4e-02	NA	1.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Length of working week for main job	4.1	4.6	11.1	-0.0	-0.7	-3.3	-2.6
Other serious medical condition/disability diagnosed by doctor	3.5	4.6	13.4	2.1	-3.7	-0.1	-0.8
Birth weight of first child	3.3	6.0	17.2	-1.0	-0.8	-4.2	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	3.3	6.9	14.6	-0.2	-2.0	-3.0	-3.8
Mouth/teeth dental problems: Loose teeth	3.2	3.8	4.2	-2.0	-1.9	-1.9	-1.9
Alcohol drinker status: Previous	3.2	3.6	9.6	0.0	-3.1	-1.2	-1.8
Hearing aid user	3.0	3.4	7.2	1.5	0.2	2.7	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.0	17.2	-1.3	-1.8	-3.7	-4.1
Medication: Atenolol	2.6	3.2	9.6	-0.3	-0.6	3.1	1.7
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	17.4	-2.1	-1.3	-3.4	-4.2
Breastfed as a baby	2.6	3.2	5.4	-1.5	1.8	2.3	1.4
Financial difficulties in last 2 years	2.5	3.3	8.6	-1.3	-2.9	-0.7	-1.5
Alzheimer’s Disease (in mother)	2.4	2.9	6.4	2.5	0.8	1.9	1.0
Exposure to tobacco smoke at home	2.4	2.7	6.2	-0.8	-0.2	2.5	2.0
Forced vital capacity (FVC), Best measure	2.4	8.8	17.7	-1.6	-1.9	-3.4	-4.2
Fractured/broken bones in last 5 years	2.4	3.1	8.1	1.7	-2.9	-1.1	-0.2
Diastolic blood pressure, automated reading	2.2	6.8	8.8	-3.0	-2.6	-2.9	-1.9
Breast cancer (self-reported)	2.1	2.5	7.6	1.6	-2.8	-0.0	-0.3
Height	2.0	38.1	85.2	-4.6	-4.8	-4.8	-9.2
Financial situation satisfaction	2.0	2.5	4.5	-1.9	-2.1	-1.2	-0.7
Forced vital capacity (FVC)	1.9	7.3	16.1	-1.8	-1.6	-2.7	-4.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	10.4	-1.4	-0.8	-3.2	-1.8
Number of self-reported non-cancer illnesses	1.8	3.1	5.3	2.3	0.1	1.7	2.0
Risk taking	1.8	2.7	8.4	0.6	-2.9	1.3	-0.6
Multivitamins +/- minerals	1.7	2.2	5.5	1.7	0.3	2.3	0.4
Noisy workplace	1.7	2.1	3.6	1.9	0.9	1.0	1.7
Pulse wave reflection index	1.7	2.1	3.7	-0.9	-1.9	-1.2	-1.6
Reaction Time	1.6	3.1	10.6	-0.9	-3.3	-0.9	0.2
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	5.1	1.1	-2.3	-0.9	-0.5
Sitting height	1.6	11.5	27.1	-2.5	-2.8	-2.1	-5.2
Hair/balding pattern: Pattern 4	1.6	3.9	15.2	0.6	-3.9	-0.2	-0.1
Number of children fathered	1.6	1.8	5.1	0.2	1.2	0.7	2.3
Chest pain or discomfort	1.6	2.4	7.8	1.0	-2.8	-0.7	-0.3
Fasting Glucose	1.5	1.8	4.2	0.9	2.0	0.4	1.4
Severe depression (siblings)	1.5	1.6	3.6	-1.9	-1.3	1.1	0.2
Pain all over the body in last month	1.5	1.6	4.8	0.8	-2.2	-0.9	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.4	5.4	-1.1	-0.3	1.6	2.3
Number of full brothers	1.5	1.9	4.2	-0.1	-1.1	-1.5	-2.0
Medication: Blood pressure	1.5	2.6	5.6	0.9	0.7	1.9	2.4
Alcohol drinker status: Never	1.5	1.8	4.2	1.1	-0.4	2.0	1.4
Number of operations (self-reported)	1.5	2.2	6.3	1.5	-2.5	-0.7	0.1
Bipolar Disorder (2011)	1.4	1.4	5.3	0.5	-2.3	0.0	0.0
Relative age voice broke	1.4	2.1	3.3	1.7	1.4	-1.8	-0.5
Serious illness, injury or assault to yourself	1.4	1.7	5.8	0.9	-2.4	0.4	0.2
Supplements: Glucosamine	1.4	1.8	3.3	0.7	-1.6	1.8	-1.0
Standing height	1.4	14.1	33.4	-0.9	-4.2	-2.1	-5.8
Worry too long after embarrassment	1.4	2.3	3.7	-0.1	-1.9	-1.8	-1.5
Ulcerative Colitis (UC)	1.3	2.4	4.5	2.1	0.3	-1.9	-1.2
Triglycerides	1.3	2.1	3.6	1.4	1.6	1.9	0.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.5	2.4	0.6	-0.4	0.9
Peak expiratory flow (PEF)	1.3	3.1	5.4	-1.9	-0.1	-2.3	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	3.5	0.1	1.4	1.9	-0.9
Comparative height size at age 10	1.3	7.1	19.2	0.7	-2.5	-1.5	-4.4
Long-standing illness, disability or infirmity	1.3	1.9	5.7	1.3	0.2	2.4	0.6
Mineral and other dietary supplements	1.3	1.7	5.4	-1.2	0.2	-2.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	5.0	0.6	-2.2	0.8	-0.6
High blood pressure	1.2	3.3	6.6	0.4	1.3	2.2	2.6
Illnesses of siblings	1.2	1.6	3.8	1.3	-1.0	1.9	-0.4
Pulse wave Arterial Stiffness index	1.2	1.4	2.0	-1.4	0.2	-1.4	-1.2
Tense / ‘highly strung’	1.2	2.0	7.5	0.0	-2.7	0.4	-0.6
Average weekly red wine intake	1.2	1.7	3.1	1.8	-1.6	0.4	1.0
Wears glasses or contact lenses	1.2	1.3	4.4	-0.7	0.1	0.7	2.1
Ulcerative Colitis	1.1	1.6	2.9	1.6	-0.2	-1.7	-1.1
Had other major operations	1.1	1.4	2.7	1.6	-0.8	0.8	1.3
Falls in the last year	1.1	1.4	2.9	1.4	-1.7	-0.6	-0.8
Blood clot in the leg (DVT)	1.1	1.4	4.2	0.7	-2.0	0.8	-0.5
Medication: Seretide 50 evohaler	1.1	1.3	3.0	0.4	0.2	1.4	1.7
Supplements: Vitamin C	1.1	1.3	2.9	1.1	-1.7	0.7	0.9
Knee pain experienced in last month	1.1	1.7	5.3	0.6	-1.0	-0.6	-2.3
Hypertension (Self-reported)	1.1	2.9	6.1	0.5	1.3	1.9	2.5
Illnesses of siblings: Diabetes	1.1	1.4	2.2	-1.5	0.6	-1.3	1.2
Leg predicted mass (right)	1.1	5.8	15.4	0.2	-3.9	-0.9	-2.6
Medication: Bendroflumethiazide	1.1	1.7	2.6	-0.9	1.4	1.2	1.6
Medication: Atorvastatin	1.1	1.4	2.5	0.9	-1.2	0.9	1.6
Vascular/heart problems diagnosed by doctor	1.1	3.1	6.1	-0.3	-1.0	-2.3	-2.5
Cholesterol lowering medication	1.1	1.7	2.7	0.6	1.2	1.5	1.6
Alzheimer’s Disease (including proxy)	1.0	1.4	2.6	0.8	1.6	1.3	0.9
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.5	-0.6	-2.1	0.7	-0.6
Vitamin and mineral supplements	1.0	1.4	3.5	-0.5	1.3	-1.9	-0.3
Taking other prescription medications	1.0	1.6	5.0	1.0	-2.2	0.1	-0.7
Number of live births	1.0	1.4	2.7	-0.0	1.6	0.6	1.6
Lung cancer (father)	1.0	1.2	2.9	0.1	-1.7	0.2	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.2	-0.7	-2.0	0.2	0.6
Pulse wave peak to peak time	1.0	1.2	1.9	1.4	-0.6	1.3	0.8
Mean time to correctly identify matches	1.0	2.0	7.0	-0.9	-2.6	-0.2	0.3
Whole body fat-free mass	1.0	5.8	11.8	0.2	-3.4	-1.2	-3.1
Leg fat-free mass (right)	1.0	5.5	14.9	0.3	-3.9	-0.9	-2.5
Ever had bowel cancer screening	1.0	1.2	3.8	0.7	-0.1	2.0	-0.7
Whole body water mass	1.0	5.5	11.4	0.1	-3.4	-1.1	-3.1
High cholesterol (Self-reported)	1.0	1.8	3.9	1.2	2.0	0.4	1.3
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.3	1.5	1.3	0.2	-0.9
Bipolar Disorder (2018)	0.9	1.4	2.7	-0.6	-1.6	-1.6	-0.4
Bipolar Disorder or Schizophrenia	0.9	2.3	4.3	1.0	-2.1	-1.7	-1.1
Neuroticism (Nagel 2018)	0.9	2.2	8.1	-0.5	-2.8	0.1	-0.6
Major Depression (MDD)	0.9	1.1	2.6	1.6	0.2	-0.1	1.3
HbA1C	0.9	1.0	2.3	0.5	-0.5	1.5	1.2
Waist Hip Ratio (WHR)	0.9	4.1	7.9	-0.6	2.6	-2.8	-1.1
Sensitivity / hurt feelings	0.9	1.5	4.8	0.7	-2.2	0.5	-0.6
Hearing difficulty/problems: Yes	0.9	1.4	2.5	-1.2	1.2	0.5	1.6
Leg fat-free mass (left)	0.9	5.0	11.2	0.3	-3.4	-1.2	-2.7
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.9	-1.4	-1.1	-0.3	-0.9
Medication: Levothyroxine sodium	0.9	1.4	4.5	2.1	0.9	0.2	-0.7
Leg predicted mass (left)	0.9	4.9	11.3	0.3	-3.4	-1.2	-2.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.9	-0.5	-1.7	1.4	0.8
Trunk fat-free mass	0.9	5.3	10.8	-0.1	-3.0	-1.2	-3.3
Worrier / anxious feelings	0.9	1.6	2.8	0.8	-1.6	-0.7	-1.7
Mouth/teeth dental problems: Dentures	0.9	1.6	3.3	-0.3	1.5	0.9	1.8
Asthma	0.9	1.7	3.0	-0.4	-1.1	1.7	1.5
Medication: Lansoprazole	0.9	1.0	3.0	-1.7	-0.2	-0.7	0.8
Trunk predicted mass	0.9	5.4	11.0	-0.2	-3.0	-1.2	-3.3
Qualifications: nursing, teaching	0.9	1.4	2.1	1.4	1.3	-1.1	0.8
Ever smoked	0.9	1.7	4.2	-2.1	-1.4	0.7	0.2
Basal metabolic rate	0.9	5.2	10.8	0.1	-3.3	-1.2	-2.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.9	0.4	-0.2	-1.2	-1.7
Worry (Nagel 2018)	0.8	1.6	4.5	0.5	-2.1	-0.3	-1.3
Irritable Bowel Disease (IBD)	0.8	1.8	4.5	2.1	1.0	-1.3	-0.2
HDL Cholesterol	0.8	1.4	2.3	1.3	-1.5	-1.1	0.3
Medication: Co-codamol	0.8	0.9	3.5	0.1	-0.2	1.9	0.2
Average weekly fortified wine intake	0.8	0.9	1.6	-0.9	1.0	1.2	0.4
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.8	1.6	0.8	-0.8	1.7
Time employed in main current job	0.8	1.0	2.5	0.3	-0.2	-1.1	-1.6
Pulse rate	0.8	1.4	4.6	0.0	2.2	0.4	0.8
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.7	1.0	-0.3	1.3	1.2
Arm fat-free mass (right)	0.8	4.0	8.1	-0.1	-2.8	-1.1	-2.6
Neck or shoulder pain in last month	0.8	1.1	1.6	-0.8	-1.2	1.3	0.8
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.6	0.6	-1.3	-1.2	-0.7
Friendships satisfaction	0.8	1.0	1.7	0.5	-1.0	-1.0	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.9	0.1	-0.9	-0.9	-1.4
Age started oral contraceptive pill	0.8	1.0	2.1	0.9	0.3	-1.5	-1.0
Schizophrenia (2018)	0.7	1.5	2.9	1.7	-1.4	-0.7	-0.9
Alzheimer’s Disease (in father)	0.7	0.7	1.3	-1.0	0.8	-1.1	0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.8	-1.2	-2.2	-0.3	0.1
Ever had hysterectomy (womb removed)	0.7	0.7	2.4	0.1	-0.7	-0.4	-1.6
Diabetes (mother)	0.7	0.9	2.3	1.5	0.4	-0.5	-1.0
Hair/balding pattern: Pattern 2	0.7	0.9	2.3	-1.5	1.0	-0.4	0.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.6	-0.1	-1.3	-0.7	-1.1
Glaucoma (self-reported)	0.7	0.8	1.7	-1.3	0.5	0.2	-1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.4	1.0	0.0	-0.9	-1.9
Medication: Ibuprofen	0.7	0.8	1.6	0.9	-0.3	-0.8	-1.3
Arm predicted mass (right)	0.7	3.4	6.6	-0.2	-2.5	-0.9	-2.6
Leg pain on walking	0.7	0.9	3.1	-0.7	-0.3	0.0	-1.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.4	0.8	1.2	1.0	0.7
Loneliness, isolation	0.7	1.0	2.0	-1.3	-0.5	1.4	-0.0
Medication for cholesterol	0.7	1.1	2.1	-0.9	-0.8	-1.5	-0.8
Asthma (self-reported)	0.7	1.3	2.5	-0.4	-1.0	1.6	1.3
Osteoporosis (self-reported)	0.7	0.8	1.5	0.9	0.9	-0.2	1.2
Miserableness	0.7	1.1	2.5	-1.6	-0.8	0.7	0.9
Arm fat-free mass (left)	0.7	3.5	8.2	0.2	-2.9	-1.0	-2.2
Irritability	0.7	1.2	4.1	-0.1	-2.0	0.7	-0.2
Commuting to job workplace: Cycle	0.7	0.9	2.5	-1.0	1.6	-0.0	0.3
Pack years of smoking	0.7	1.0	1.7	1.0	-0.7	1.3	0.7
Arm predicted mass (left)	0.7	3.8	7.9	0.3	-2.8	-1.1	-2.5
Age at First Birth	0.6	0.9	1.4	-0.7	1.2	-0.5	1.2
Mean Putamen Volume	0.6	0.7	1.7	-0.5	-1.3	-0.9	-0.1
Lupus	0.6	0.9	2.4	1.5	-0.9	0.7	0.1
Schizophrenia (2014)	0.6	1.3	3.1	1.8	-1.4	0.1	-0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.5	-0.2	-1.1	-1.2	0.5
Allergy or Eczema	0.6	1.5	3.0	0.6	1.2	-0.9	1.7
Hypothyroidism (self reported)	0.6	1.4	3.8	0.9	-0.6	-0.9	-1.9
Maternal smoking around birth	0.6	0.9	3.3	-1.8	-0.0	-0.4	-0.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	0.6	1.3	0.5	-0.5
Past tobacco smoking	0.6	1.1	3.5	1.9	0.8	-0.6	-0.0
Allergy	0.6	1.5	2.9	-1.6	0.4	-0.7	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.7	0.7	-1.6	0.8	0.4
Hair/balding pattern: Pattern 3	0.6	0.9	2.0	-1.4	0.5	0.3	-1.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.0	0.7	-0.6	-1.0	-0.9
Exposure to tobacco smoke outside home	0.6	0.8	1.0	-0.7	1.0	0.9	0.9
Migraine (self-reported)	0.6	0.7	1.8	0.6	1.3	0.5	0.7
Suffer from ‘nerves’	0.6	1.0	1.7	-0.9	-1.1	-0.0	-1.3
Medication: Aspirin	0.6	0.7	1.4	1.1	-1.2	0.0	0.5
Illnesses of father: Heart disease	0.6	0.8	1.9	-0.3	0.7	0.9	1.4
Mood swings	0.6	1.0	1.5	-0.1	-1.1	1.2	1.2
Mother’s age at death	0.6	0.8	3.0	-0.3	-0.3	-0.0	-1.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.7	0.2	-1.6	-0.1	0.2
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.2	0.5	-2.3	0.5	1.0
Prostate Cancer	0.5	0.7	2.1	0.3	0.9	1.4	0.1
Coronary Artery Disease (CAD)	0.5	0.6	1.6	0.7	1.3	0.6	0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.9	1.4	0.2	0.5	0.4
Hand grip strength (right)	0.5	1.4	3.4	-1.8	-1.3	-0.7	-0.1
Qualifications: CSEs or equivalent	0.5	0.7	1.2	0.8	0.1	-1.1	-0.9
Heart attack	0.5	0.7	1.2	-0.9	-0.1	0.8	1.1
Diabetes (self-reported)	0.5	0.8	1.9	1.4	-0.9	0.0	-0.7
Medication: Ramipril	0.5	0.6	1.0	1.0	0.8	1.0	0.0
Weight	0.5	2.5	6.6	-0.1	-2.6	-0.8	-1.6
Hip circumference	0.5	2.3	8.1	0.4	-2.9	0.1	-0.9
Depression (self-reported)	0.5	0.6	1.5	-1.2	-0.3	0.6	0.7
Medication: Amlodipine	0.5	0.8	1.9	1.4	0.4	0.4	0.9
Age at first live birth	0.5	0.8	2.0	-1.1	0.1	-1.4	-0.0
Health satisfaction	0.5	0.7	1.5	0.2	-0.1	-1.2	-1.1
Medication: Omeprazole	0.5	0.6	2.0	0.4	-0.4	-0.5	-1.4
Number of full sisters	0.5	0.7	1.3	-0.3	0.4	1.1	1.1
Back pain experienced in last month	0.5	0.7	1.5	1.0	0.5	0.2	-1.2
Osteoarthritis (self-reported)	0.5	0.7	1.9	-0.8	-0.1	-0.4	-1.4
Ever taken oral contraceptive pill	0.5	0.6	1.7	1.3	-0.5	-0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.1	1.1	-0.6	0.9	-0.5
Average weekly beer plus cider intake	0.5	0.8	2.1	-0.5	1.4	0.6	0.7
Ever depressed for a whole week	0.5	0.6	1.4	0.4	-1.2	-0.4	-0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.0	-0.9	-0.2	0.9	1.0
Depressed Affect (Nagel 2018)	0.4	0.8	1.6	-0.7	-1.3	1.0	0.6
Depression (Nagel 2018)	0.4	0.6	1.3	-0.2	-1.1	-0.2	-1.0
Schizophrenia vs Biploar Disorder	0.4	0.6	1.1	1.0	-0.2	-0.3	-1.0
Crohns Disease (2017)	0.4	0.8	1.7	0.6	1.3	-0.0	1.1
Ovarian Cancer	0.4	0.5	1.4	0.1	0.7	-1.2	-0.1
Crohns Disease (2012)	0.4	0.6	1.8	0.5	1.3	0.0	0.7
LDL Cholesterol	0.4	0.6	1.3	-0.2	-0.7	0.7	-1.2
Rheumatoid Arthritis	0.4	0.6	2.1	-0.6	1.4	-0.0	-0.2
Cardiovascular Disease	0.4	1.5	4.7	0.7	0.8	0.4	2.2
Lung FVC	0.4	2.0	2.8	-1.4	-1.5	-1.7	-1.0
Hand grip strength (left)	0.4	0.9	3.1	-0.8	-1.8	0.1	0.1
Systolic blood pressure, automated reading	0.4	1.2	4.0	-2.0	0.0	-0.0	-0.8
Supplements: Zinc	0.4	0.5	0.7	0.9	-0.6	-0.5	-0.7
Trunk fat mass	0.4	1.6	4.7	-0.3	-2.2	-0.8	-0.9
Medication: Simvastatin	0.4	0.6	0.9	0.9	0.9	0.9	-0.0
Fluid intelligence score	0.4	0.8	2.8	-0.2	-1.7	0.0	0.5
Loud music exposure frequency	0.4	0.4	1.4	0.4	-1.2	0.3	0.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	0.2	-0.3	1.2	-0.7
Gout (self-reported)	0.4	0.6	2.1	-0.2	-1.4	-0.3	-0.4
High blood pressure (siblings)	0.4	0.5	1.9	-0.4	0.1	-1.4	-0.2
Wheeze or whistling in the chest in last year	0.4	0.7	1.6	0.5	-0.7	1.3	0.7
Heart disease (mother)	0.4	0.5	0.8	-0.4	-0.6	-0.9	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	1.1	0.7	0.4	0.2
Overall health rating	0.4	0.9	1.9	0.7	-1.4	1.0	0.1
Age at last live birth	0.4	0.5	1.2	-0.8	-0.4	-1.1	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.4	-0.0	1.2	0.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	-0.5	0.9	-0.6	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	1.1	-0.6	0.3	0.6
Diabetes diagnosed by doctor	0.4	0.7	1.5	1.2	-1.0	0.2	-0.5
Medication: Aspirin	0.4	0.5	1.5	0.6	-1.2	-0.2	0.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-1.0	0.7	-0.1	-0.5
Medication: Blood pressure	0.4	0.7	1.6	0.4	0.4	1.3	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	1.1	0.7	-0.2	-0.7
Unable to work because of sickness or disability	0.4	0.5	0.9	-0.5	-0.8	-0.9	-0.6
Pain experienced in last month	0.4	0.6	2.0	-0.6	0.0	-1.4	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.8	0.0	-0.9	-0.7	-0.8
Neuroticism	0.3	0.8	2.7	-0.5	-1.6	0.3	0.1
Chronotype (morning person)	0.3	0.8	1.4	-0.4	-1.2	-0.9	-0.8
Relative age of first facial hair	0.3	0.5	1.2	1.1	-0.5	-0.6	0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.7	0.5	-0.8	-0.4	-0.6
Angina	0.3	0.4	1.3	0.4	-1.2	-0.0	-0.3
Medication for hormone replacement therapy	0.3	0.4	0.6	-0.6	0.1	-0.8	-0.7
Diabetes (father)	0.3	0.4	1.1	-1.1	-0.3	-0.5	0.1
Pack years adult smoking proportion	0.3	0.5	0.9	0.9	-0.9	0.6	0.2
Townsend deprivation index at recruitment	0.3	0.4	1.0	-0.7	-1.0	0.4	0.2
Stomach or abdominal pain in last month	0.3	0.4	0.8	0.4	0.9	0.6	0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	-0.2	0.4	1.0	0.6
High blood pressure (mother)	0.3	0.4	1.0	0.5	0.0	-0.6	-1.0
Number of incorrect matches in round	0.3	0.6	1.1	0.7	-0.3	1.1	0.8
Qualifications: None of the above	0.3	0.7	1.5	-1.2	0.8	-0.6	0.2
Mouth/teeth dental problems	0.3	0.4	1.0	0.9	0.1	-1.0	-0.0
Neuroticism score	0.3	0.6	1.6	-0.8	-1.3	-0.3	-0.4
Happiness	0.3	0.4	0.7	0.8	-0.4	0.8	-0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.7	-0.1	-0.8	-1.3	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	-0.7	0.3	-0.9	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	-0.3	-0.1	-0.5	-1.0
Prospective memory result	0.3	0.4	1.1	0.4	-0.1	1.1	-0.7
Illnesses of mother	0.3	0.4	1.4	-1.2	0.3	0.1	-0.2
Birth weight	0.3	0.6	1.4	1.0	-0.1	0.4	1.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	-0.9	0.3	0.3	0.7
Qualifications: College or University degree	0.3	0.9	1.7	1.3	-1.3	0.0	0.6
Medication: Allopurinol	0.3	0.4	1.3	0.0	-1.1	0.2	0.4
Had major operations	0.3	0.4	1.4	-0.3	-0.1	-1.2	-0.1
Smoking status: Previous	0.3	0.5	1.5	-1.2	-0.4	0.4	0.1
Medication: Lisinopril	0.3	0.4	1.6	-0.1	0.0	0.3	1.3
Breast Cancer	0.2	0.6	2.1	0.1	-1.5	0.1	0.4
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.1	0.9	0.6	0.3
Neuroticism (2016)	0.2	0.2	0.5	-0.7	-0.3	0.2	-0.5
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.0	1.0	-0.6	0.2
Heel T-Score	0.2	1.3	3.0	1.1	0.6	0.8	1.7
Smoking Status	0.2	0.4	0.7	-0.7	0.2	0.5	0.8
Lung FEV1/FVC ratio	0.2	1.0	2.0	-1.4	-0.3	-0.8	-1.1
Tanning	0.2	3.0	5.4	-2.3	-1.1	-1.2	-1.9
Average weekly spirits intake	0.2	0.2	0.4	-0.6	-0.5	-0.1	-0.5
Impedance of leg (right)	0.2	1.1	3.8	-0.3	2.0	-0.7	-0.1
Trunk fat percentage	0.2	0.7	2.5	-0.2	-1.6	-0.5	0.0
Fed-up feelings	0.2	0.3	0.8	-0.1	-0.9	-0.6	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.3	-0.0	1.1	-0.1	0.6
Arm fat mass (right)	0.2	0.7	2.2	-0.2	-1.5	-0.7	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	1.0	-0.4	0.2	0.1
Medication: Paracetamol	0.2	0.3	0.5	-0.7	0.6	0.1	0.5
Headache pain in last month	0.2	0.4	0.7	0.8	-0.3	-0.5	-0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	-0.5	-0.0	-0.6	-0.7
Leg fat percentage (right)	0.2	0.8	2.8	0.1	0.5	-0.0	1.7
Shortness of breath walking on level ground	0.2	0.2	0.6	0.5	0.1	-0.7	0.1
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.7	0.5	0.3	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	0.6	0.2	0.5	0.8	0.7
Angina (self-reported)	0.2	0.3	1.1	0.2	-1.0	0.0	-0.2
Whole body fat mass	0.2	1.0	3.6	-0.3	-1.9	-0.5	-0.3
Pulse rate, automated reading	0.2	0.6	1.2	-0.6	1.1	-0.9	0.4
Commuting to job workplace: Walk	0.2	0.3	0.6	0.1	0.7	-0.1	-0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.3	-0.3	-0.2	-0.8
Smoking status: Current	0.2	0.4	0.9	-0.6	0.2	1.0	0.4
Arm fat mass (left)	0.2	0.6	2.0	-0.1	-1.4	-0.6	-0.3
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.2	0.6	0.1	0.7
Medication: Paracetamol	0.2	0.3	0.7	-0.4	0.9	-0.0	0.5
Leg fat percentage (left)	0.2	0.8	3.0	-0.1	-0.3	0.0	1.7
Myopia	0.2	0.3	0.6	-0.5	-0.8	0.4	-0.2
Blood Eosinophil Count	0.1	0.6	1.0	-0.8	-1.0	-1.0	-0.1
Blood Platelet Count	0.1	0.7	1.3	-0.7	1.1	0.5	0.8
Blood Red Count	0.1	0.6	1.6	0.1	0.8	0.1	1.3
Blood White Count	0.1	1.0	3.5	0.3	0.1	0.4	1.9
BMI	0.1	0.5	1.1	0.1	-0.8	-1.1	0.4
Hair Pigment	0.1	3.1	6.2	-0.1	2.1	1.4	2.5
Number of treatments/medications taken	0.1	0.2	0.4	0.4	-0.2	0.5	-0.6
Medication: Metformin	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.2
Current tobacco smoking	0.1	0.2	0.3	-0.4	-0.3	0.6	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	-0.1	-0.2	0.6	0.5
Age when periods started (menarche)	0.1	0.2	0.4	0.6	0.0	-0.5	-0.2
Body mass index (BMI)	0.1	0.5	1.3	0.3	-0.8	0.1	1.1
Impedance of leg (left)	0.1	0.4	1.2	-0.5	1.1	-0.3	0.3
Waist circumference	0.1	0.4	1.0	-0.3	-1.0	-0.5	-0.2
Alcohol usually taken with meals	0.1	0.2	0.3	0.6	-0.6	-0.2	0.3
Nervous feelings	0.1	0.1	0.3	-0.3	0.6	-0.0	-0.1
Had menopause	0.1	0.1	0.1	0.3	-0.3	-0.4	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.0	0.6	-0.5	0.8
Impedance of arm (right)	0.1	0.4	0.8	-0.3	-0.2	-0.8	-0.9
Arm fat percentage (right)	0.1	0.4	0.8	-0.3	-0.9	-0.5	0.6
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.1	0.2	-0.6	-0.1
Father’s age at death	0.1	0.1	0.4	0.3	-0.3	0.1	-0.6
Medication: Cholesterol lowering	0.1	0.2	0.7	0.8	0.0	0.2	-0.1
Impedance of arm (left)	0.1	0.6	1.4	-0.8	0.3	-0.7	-1.2
Body fat percentage	0.1	0.4	1.3	-0.2	-1.1	-0.3	0.5
Comparative body size at age 10	0.1	0.3	0.4	-0.7	-0.5	-0.1	0.6
Eye problems/disorders: None of the above	0.1	0.2	0.4	0.7	0.5	0.0	0.1
Leg fat mass (right)	0.1	0.3	1.1	0.1	-1.0	-0.2	0.2
Alcohol intake frequency.	0.1	0.2	0.6	0.8	0.1	-0.6	-0.2
Arm fat percentage (left)	0.1	0.2	0.3	-0.5	-0.6	-0.4	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.2	-0.4	-0.3	-0.4
Eye problems/disorders: Cataract	0.1	0.1	0.5	-0.0	-0.7	-0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	-0.1	-0.6	-0.1	-0.7
Medication: Gliclazide	0.1	0.1	0.4	-0.6	-0.2	-0.2	-0.3
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.7	-0.6	0.1	0.0
Guilty feelings	0.1	0.2	0.5	-0.7	0.2	-0.2	0.1
Illnesses of father: High blood pressure	0.1	0.2	0.6	-0.1	0.1	0.8	-0.0
Supplements: Calcium	0.1	0.1	0.3	0.2	-0.6	0.4	-0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.1	0.2	-0.5	-0.4
Heart disease (siblings)	0.1	0.1	0.2	-0.5	0.2	-0.3	0.4
Impedance of whole body	0.1	0.4	0.6	-0.5	0.7	-0.7	-0.4
Leg fat mass (left)	0.1	0.5	2.0	0.1	-1.4	-0.0	0.3
Systolic Blood Pressure	0.0	0.2	0.7	-0.8	-0.0	0.2	0.4
Respiratory disease	0.0	0.1	0.3	0.3	-0.6	0.2	0.1
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.0	-0.1	0.3	0.4
Family relationship satisfaction	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.3

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