Hub : Genes

TXNDC12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0490	0.0310	1.3e-02	-0.001	0.006	0.002	0.007	-0.002	5.2e-01	5.8e-02	1.7e-01	4.7e-02	5.8e-01
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1200	0.0560	4.1e-03	0.006	NA	0.027	NA	0.017	1.4e-01	NA	1.2e-02	NA	3.7e-02
3	GTEx	Whole Blood	0.1290	0.0600	3.8e-04	0.042	NA	0.076	NA	0.076	8.7e-05	NA	1.8e-07	NA	1.7e-07
4	ROSMAP	Brain Pre-frontal Cortex	0.0768	0.0361	1.5e-02	0.051	0.000	0.045	0.029	0.038	3.2e-07	3.1e-01	1.8e-06	9.9e-05	9.7e-06
5	YFS	Blood	0.1734	0.0411	4.5e-13	0.076	0.047	0.066	0.075	0.074	7.9e-24	5.0e-15	7.5e-21	1.7e-23	5.2e-23

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.5	4.2	-2.0	-0.8	0.4	1.5	0.6
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	-0.4	-0.6	0.8	0.9	0.1
Depressed Affect (Nagel 2018)	0.7	1.4	2.4	-1.6	-0.9	0.4	-1.5	-1.2
Depression (Nagel 2018)	0.3	0.4	0.8	-0.9	-0.8	0.7	-0.1	-0.3
Intelligence (Savage-Jansen 2018)	1.1	3.3	15.3	-3.9	-0.7	0.7	-0.5	0.0
Neuroticism (Nagel 2018)	1.2	2.7	4.9	-1.5	-1.0	-0.7	-2.2	-2.2
Schizophrenia (2018)	0.2	0.4	0.7	0.8	-0.3	0.1	-0.6	-0.9
Schizophrenia vs Biploar Disorder	0.8	1.0	2.0	1.4	-0.1	1.2	0.9	0.9
Worry (Nagel 2018)	0.8	1.6	4.0	-0.0	0.4	-0.8	-1.8	-2.0
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.2	-0.1	0.2	-0.0	-0.2
Alzheimer’s Disease (in father)	1.6	1.7	4.2	-0.1	0.7	1.3	2.1	1.5
Alzheimer’s Disease (including proxy)	0.3	0.5	0.7	-0.6	-0.3	0.8	0.8	0.7
Crohns Disease (2017)	1.5	3.2	7.8	1.5	-0.4	1.3	2.8	2.0
Irritable Bowel Disease (IBD)	1.3	3.0	8.4	2.9	-0.9	0.5	2.0	1.2
Ulcerative Colitis (UC)	1.2	2.2	10.2	3.2	-0.8	-0.2	0.4	0.2
Major Depression (MDD)	1.1	1.3	5.1	-2.3	-0.2	-0.1	-0.6	-1.0
Reaction Time	0.9	1.8	2.9	1.0	-1.0	-1.7	-1.4	-1.5
Verbal and Numeric Reasoning (VNR)	1.4	3.5	16.7	-4.1	-0.4	0.3	-0.4	-0.4
Breast Cancer	1.0	2.3	4.5	0.4	-0.8	2.1	1.6	1.9
Ovarian Cancer	1.5	1.9	4.2	-0.8	1.1	2.0	1.6	1.1
Prostate Cancer	0.9	1.3	3.5	1.9	-0.3	-1.0	-0.9	-1.2
Age at First Birth	1.4	2.1	5.4	1.8	2.3	-0.3	1.0	0.8
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.5	0.4	0.0	0.0	-0.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.7	-0.4	0.2	0.4	0.8
Coronary Artery Disease (CAD)	0.4	0.5	1.0	-0.2	-1.0	0.5	0.7	0.9
Crohns Disease (2012)	2.5	4.1	6.5	2.3	0.6	1.6	2.5	2.4
Mean Putamen Volume	1.7	2.0	8.9	-3.0	-1.0	0.2	-0.3	0.1
Fasting Glucose	1.3	1.6	6.7	2.6	-0.7	0.4	0.2	0.8
HbA1C	1.1	1.2	3.8	-0.3	-2.0	0.4	-1.3	-0.6
HDL Cholesterol	0.2	0.3	1.0	0.4	-0.4	-0.6	-1.0	-0.1
LDL Cholesterol	0.7	1.1	4.0	-2.0	-0.2	1.0	0.3	-0.3
Lupus	2.8	4.2	8.4	-1.2	-1.1	-1.6	-2.8	-2.9
Neuroticism (2016)	1.1	1.6	3.0	-1.2	-0.6	-1.1	-1.4	-1.7
Primary Biliary Cirrhosis	0.1	0.2	0.6	-0.8	-0.4	-0.1	-0.4	-0.2
Rheumatoid Arthritis	0.6	0.9	1.9	0.3	0.9	1.0	1.4	0.8
Schizophrenia (2014)	0.1	0.1	0.5	0.0	-0.7	0.4	-0.1	-0.2
Triglycerides	0.7	1.1	1.7	-1.1	0.9	1.2	1.3	0.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.6	-0.3	-1.1	-1.3	-0.7	-1.3
Ulcerative Colitis	1.5	2.2	10.6	3.3	0.2	-0.4	0.4	-0.0
Blood Eosinophil Count	0.1	0.5	1.7	1.3	-0.5	-0.3	-0.7	0.4
Blood Platelet Count	0.2	2.0	4.5	-1.9	-1.1	2.1	0.6	-0.1
Blood Red Count	0.5	5.2	10.2	1.7	1.9	2.1	2.1	3.2
Blood White Count	0.2	1.8	6.1	1.4	-2.5	-0.8	-0.6	0.2
Heel T-Score	0.8	6.7	18.1	-4.2	-1.6	-1.7	-2.4	-2.0
BMI	0.4	2.4	6.1	2.0	-1.3	-0.2	0.5	2.5
Height	0.6	10.6	43.4	2.6	6.6	1.0	1.2	0.7
Waist Hip Ratio (WHR)	0.1	0.5	0.9	-1.0	0.9	0.5	-0.1	-0.7
Systolic Blood Pressure	0.2	1.0	4.4	-0.4	2.1	0.5	-0.1	0.3
Smoking Status	0.5	1.1	4.5	-0.3	0.2	0.9	-2.1	-0.4
Allergy or Eczema	0.2	0.5	1.0	-0.7	0.6	0.7	1.0	0.0
Cardiovascular Disease	0.2	0.8	1.8	0.7	0.4	0.8	0.9	1.3
Hypothyroidism (self reported)	0.6	1.5	2.2	0.9	1.1	1.5	1.3	1.2
Respiratory disease	0.4	0.8	1.5	1.2	-0.5	-0.7	-0.7	-1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.4	-1.0	-1.5	-0.1	-0.1	0.2
Lung FEV1/FVC ratio	0.0	0.2	0.5	0.7	-0.1	0.1	-0.6	-0.4
Lung FVC	0.2	0.9	3.0	-0.5	1.7	-0.8	0.5	-0.5
Neuroticism	1.1	2.7	7.6	-0.7	0.3	-1.2	-1.9	-2.8
Chronotype (morning person)	0.7	1.7	3.4	-0.1	-0.4	1.8	1.6	1.5
Hair Pigment	0.0	0.9	2.9	1.7	-0.7	-1.0	-0.0	0.1
Tanning	0.1	0.7	1.6	1.3	0.7	0.8	-0.3	0.8
Hand grip strength (left)	0.2	0.6	2.0	0.1	-0.0	-0.9	-1.4	-0.3
Number of treatments/medications taken	0.1	0.1	0.5	-0.1	0.4	-0.2	0.7	-0.2
Average weekly spirits intake	0.7	0.8	2.0	0.9	1.4	-1.0	0.2	-0.3
Sensitivity / hurt feelings	0.6	1.1	2.0	-0.6	1.2	-0.8	-1.0	-1.4
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.3	-1.5	-1.3	0.1	-0.5	-0.6
Hearing difficulty/problems: Yes	1.5	2.3	4.2	-1.0	2.1	-1.2	-1.3	-1.8
Relative age of first facial hair	0.5	1.0	3.9	-2.0	-0.3	-0.8	0.6	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	-0.5	1.3	-0.0	0.6	0.2
Ever used hormone-replacement therapy (HRT)	0.9	1.1	5.2	-0.4	0.3	2.3	0.3	-0.0
Ever had hysterectomy (womb removed)	1.0	1.2	2.4	-1.6	-0.4	-0.7	-1.2	-1.2
Systolic blood pressure, automated reading	0.2	0.6	1.4	-0.6	1.2	0.8	-0.1	0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.4	0.2	0.3	0.6	0.4
Angina	0.3	0.3	0.6	-0.6	-0.7	-0.5	-0.0	-0.8
Medication for hormone replacement therapy	2.4	2.7	6.9	0.2	1.4	2.6	1.8	1.1
Vitamin and mineral supplements	0.6	0.9	2.7	0.9	-0.1	0.5	0.8	1.6
Supplements: Zinc	0.2	0.3	0.7	-0.2	0.8	-0.1	-0.7	-0.3
Medication: Co-codamol	0.4	0.5	1.1	-0.3	-1.1	-0.9	0.1	-0.6
Medication: Metformin	0.2	0.2	0.7	0.5	-0.8	-0.4	-0.1	-0.2
Diabetes (father)	1.2	1.5	5.3	-2.3	0.8	1.3	0.2	-0.0
Diabetes (mother)	0.6	0.7	2.1	0.8	-0.6	0.8	-1.4	0.3
Severe depression (siblings)	2.7	3.1	6.5	-0.4	-0.8	-2.6	-2.0	-2.0
Pack years adult smoking proportion	0.2	0.3	0.8	-0.3	-0.1	0.9	-0.7	-0.4
Impedance of leg (right)	0.6	3.1	7.7	-2.1	0.3	-0.1	-1.8	-2.8
Leg fat-free mass (left)	0.4	2.0	6.1	2.5	0.9	-0.1	0.5	1.7
Trunk fat percentage	0.3	1.1	2.8	1.7	-0.2	0.4	0.6	1.5
Hand grip strength (right)	0.1	0.3	0.6	0.1	0.6	0.8	-0.2	0.6
Townsend deprivation index at recruitment	0.2	0.2	0.6	-0.8	0.4	0.4	-0.3	-0.3
Current tobacco smoking	2.8	4.5	16.3	-0.6	-1.2	-1.1	-4.0	-1.8
Average weekly fortified wine intake	0.9	1.0	2.9	1.0	1.7	-0.6	0.1	-0.9
Maternal smoking around birth	0.9	1.3	5.2	-2.3	0.5	0.0	-1.0	-0.3
Fed-up feelings	0.9	1.6	3.9	-0.8	-0.9	-0.5	-2.0	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.8	-0.2	0.2	2.0	1.3	1.3
Relative age voice broke	1.4	2.1	5.5	-2.4	2.1	0.2	0.6	-0.1
Taking other prescription medications	0.2	0.3	0.6	0.3	0.3	0.6	0.8	0.4
Age when periods started (menarche)	0.7	1.7	6.7	-2.6	-0.4	0.7	0.6	0.8
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.9	-2.0	0.1	-0.7	-0.4	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.8	-0.9	-0.3	-0.5	0.2	0.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.9	-0.7	0.2	0.5	0.4	0.9
Qualifications: CSEs or equivalent	1.2	1.6	2.3	-0.7	-1.4	-1.4	-1.2	-1.5
Serious illness, injury or assault to yourself	0.4	0.5	1.9	0.2	1.4	-0.4	0.6	-0.1
High blood pressure	0.4	1.0	2.4	0.4	1.6	1.0	0.6	0.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.3	-0.0	1.1	0.7	1.0	0.1
Multivitamins +/- minerals	0.3	0.4	0.8	-0.3	0.8	0.3	-0.8	-0.9
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.8	0.7	0.2	0.5	-0.1
Supplements: Glucosamine	1.5	1.9	3.4	-1.8	0.1	-1.1	-1.3	-1.8
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	4.0	-1.9	-2.0	0.5	-0.1	0.5
Medication: Atenolol	1.4	1.7	3.2	1.5	1.8	0.3	1.6	0.5
Medication: Levothyroxine sodium	0.6	1.1	1.8	0.8	0.6	1.4	1.0	1.2
Sitting height	0.3	2.0	7.5	1.1	2.7	0.7	-0.4	0.7
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.1	0.1	0.2	-0.0	0.1
High blood pressure (mother)	1.1	1.6	3.7	0.6	0.0	1.4	1.4	1.9
Body mass index (BMI)	0.6	2.4	5.2	2.1	-1.4	0.1	0.7	2.3
Impedance of leg (left)	0.5	2.4	6.1	-1.6	0.7	-0.0	-1.7	-2.5
Leg predicted mass (left)	0.4	1.9	5.9	2.4	0.9	-0.2	0.4	1.6
Trunk fat mass	0.4	1.6	4.4	2.1	0.4	0.4	0.8	1.7
Waist circumference	0.2	0.8	2.7	1.6	0.3	-0.0	0.2	1.2
Number of incorrect matches in round	0.4	0.7	2.4	-0.3	0.8	-0.7	0.2	-1.5
Past tobacco smoking	0.4	0.8	1.8	0.8	-0.8	-1.4	0.4	0.7
Alcohol usually taken with meals	0.5	0.7	2.1	-1.0	1.4	0.0	0.8	0.4
Nervous feelings	0.3	0.6	1.1	0.1	1.0	-0.6	-1.0	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.1	-0.7	-0.9	-0.5	-1.4	-1.5
Hearing difficulty/problems with background noise	0.9	1.4	3.1	-0.8	1.8	-1.0	-0.6	-1.4
Hair/balding pattern: Pattern 2	0.5	0.6	1.9	-0.2	-0.8	-0.4	-1.4	-0.4
Had menopause	1.4	1.7	6.5	-0.0	2.5	1.2	-0.2	-0.7
Had other major operations	0.4	0.5	1.2	0.1	0.7	0.9	1.1	0.4
Forced vital capacity (FVC)	0.5	1.9	7.3	0.9	2.7	0.8	0.4	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.3	-1.0	-1.2	-1.5	-0.7	-1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	-1.0	-0.8	-0.5	-0.6	0.0
Qualifications: None of the above	0.5	1.0	3.3	0.5	0.2	1.8	0.7	1.0
Financial difficulties in last 2 years	0.8	1.1	3.2	-1.8	-1.4	-0.1	-0.0	-0.6
Mouth/teeth dental problems	0.3	0.4	1.3	0.2	-0.0	-0.5	1.1	0.7
Heart attack	1.5	1.9	4.6	-0.3	-0.6	-2.1	-1.5	-1.4
Allergy	0.1	0.3	0.6	-0.4	-0.6	-0.8	-0.4	0.4
Pain all over the body in last month	0.7	0.8	1.9	0.4	1.4	1.1	0.5	0.5
Diabetes (self-reported)	0.7	1.1	2.0	-1.2	-0.1	1.4	1.0	1.1
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	5.6	2.0	-0.0	0.9	2.2	2.4
Medication: Ramipril	0.6	0.8	2.3	-0.0	-0.2	-0.5	-1.5	-1.1
Medication: Simvastatin	0.5	0.7	1.4	0.7	0.2	1.2	0.9	0.9
Fluid intelligence score	1.0	2.1	9.3	-3.1	0.6	0.9	-0.0	0.0
Illnesses of siblings	1.0	1.4	2.5	0.5	0.6	1.2	1.4	1.6
Neuroticism score	0.9	2.0	5.0	-0.7	0.4	-0.8	-1.9	-2.2
Weight	0.5	2.3	6.4	2.5	0.7	0.3	0.6	2.0
Impedance of arm (right)	0.1	0.6	2.2	-0.2	0.5	-0.1	-0.5	-1.5
Arm fat percentage (right)	0.5	2.0	4.3	2.1	-1.2	0.2	0.8	1.9
Trunk fat-free mass	0.3	1.7	3.8	1.7	1.9	0.4	0.4	1.4
Hip circumference	0.4	1.8	6.8	2.6	-0.0	-0.7	-0.1	1.2
Time employed in main current job	0.3	0.3	0.8	0.8	0.0	0.5	-0.3	0.9
Alcohol intake versus 10 years previously	0.4	0.6	2.1	0.0	-0.1	0.7	0.4	1.4
Father’s age at death	0.4	0.5	1.9	-0.0	0.0	-1.4	-0.3	-0.8
Worrier / anxious feelings	0.1	0.3	1.2	0.3	1.1	-0.0	-0.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	-0.5	0.0	1.4	-0.5	0.3
Falls in the last year	1.5	2.0	5.7	0.4	0.3	-1.0	-2.4	-1.8
Hair/balding pattern: Pattern 3	0.2	0.4	0.7	0.8	-0.8	-0.5	0.5	0.2
Number of live births	0.1	0.2	0.5	0.7	0.3	-0.1	0.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.4	0.7	2.1	0.3	0.5	0.4
Pulse rate	0.9	1.6	4.7	-2.2	0.6	1.6	0.1	0.3
Happiness	1.1	1.3	2.3	1.1	-0.4	-1.5	-0.8	-1.5
Noisy workplace	1.6	2.0	4.5	-0.2	-2.1	-1.6	-1.2	-1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.2	0.3	1.0	0.0	1.5	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.3	-0.1	0.7	0.9	1.8	0.8
Mouth/teeth dental problems: Dentures	0.5	0.8	1.6	0.3	-1.2	0.2	-1.3	-0.9
Asthma	0.3	0.5	1.0	0.1	-0.7	-0.4	-0.9	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.8	0.6	1.3	0.1	0.3	0.7
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.4	-0.4	0.2	0.5	0.2
Depression (self-reported)	0.9	1.0	2.3	-1.3	0.4	-0.5	-0.9	-1.5
Medication: Lansoprazole	1.0	1.1	2.2	-0.7	0.3	1.5	1.3	1.1
Prospective memory result	0.7	0.9	2.0	-0.1	-0.1	-0.5	-1.4	-1.4
Lung cancer (father)	0.7	0.8	2.8	-0.2	1.7	0.9	0.6	-0.3
Illnesses of mother	0.7	0.8	1.8	1.1	1.4	0.1	1.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.5	0.8	1.9	0.4	0.7	0.5
Pulse wave Arterial Stiffness index	0.4	0.4	1.4	0.2	-0.2	-0.3	-0.7	-1.2
Impedance of arm (left)	0.1	0.5	0.8	-0.7	0.9	0.8	0.5	-0.6
Arm fat mass (right)	0.5	2.1	5.0	2.2	-0.5	0.3	0.8	2.1
Trunk predicted mass	0.3	1.7	3.7	1.7	1.9	0.4	0.4	1.3
Standing height	0.4	4.3	19.8	1.2	4.5	0.7	0.0	-0.1
Length of working week for main job	0.8	0.9	2.8	-1.0	-1.7	-0.1	-0.9	-0.0
Exposure to tobacco smoke at home	1.2	1.4	2.6	-0.8	-0.9	-0.7	-1.5	-1.6
Breastfed as a baby	1.1	1.3	4.3	-0.7	0.1	0.9	2.1	1.0
Tense / ‘highly strung’	1.5	2.4	5.2	0.7	-0.3	-1.3	-2.1	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	16.2	-4.0	0.9	0.8	-0.3	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	0.9	-0.3	-0.7	1.0	0.7	0.9
Birth weight of first child	0.1	0.3	0.8	-0.2	0.1	0.7	0.1	0.9
Peak expiratory flow (PEF)	0.4	0.9	4.1	0.2	2.0	0.5	0.4	0.3
Pulse wave reflection index	1.6	1.9	8.0	2.8	1.2	-0.5	0.1	-0.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	0.2	1.1	-1.2	0.1	-0.3
Loud music exposure frequency	1.5	1.6	3.8	-1.7	-1.0	-0.7	-1.9	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	-1.1	0.6	-0.9	0.2	0.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	-0.6	-1.1	0.3	-0.8	0.1
Blood clot in the leg (DVT)	0.6	0.8	1.4	-0.2	1.2	0.9	1.1	0.8
Medication: Paracetamol	1.1	1.8	4.0	2.0	1.4	-1.0	-0.4	-1.3
Headache pain in last month	0.6	1.1	4.7	2.2	0.5	-0.7	0.2	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	1.0	-0.2	0.3	0.3	0.4
Glaucoma (self-reported)	0.4	0.5	0.9	-0.2	0.9	0.8	0.9	0.3
Gout (self-reported)	0.6	0.8	3.1	-1.8	-0.6	0.4	0.5	0.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.2	0.7	1.3	1.8	1.2	1.3
Medication: Amlodipine	0.3	0.5	1.7	-1.3	0.4	0.0	0.7	0.1
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.0	0.3	-0.3	-1.4	-1.7	-1.1
Birth weight	0.2	0.5	0.9	0.6	0.8	0.4	1.0	0.8
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.5	-1.9	-0.8	-1.3	-0.5	-1.3
High blood pressure (siblings)	0.8	1.2	2.3	-0.1	0.7	-1.4	-1.5	-1.1
Forced vital capacity (FVC), Best measure	0.4	1.5	6.2	0.6	2.5	0.5	0.8	0.5
Body fat percentage	0.3	1.1	2.8	1.7	-0.4	0.4	0.5	1.5
Leg fat percentage (right)	0.2	0.7	2.2	1.5	-0.9	-0.1	-0.3	0.8
Arm fat-free mass (right)	0.3	1.7	2.8	1.6	1.5	0.5	0.7	1.7
Exposure to tobacco smoke outside home	1.6	2.1	4.1	-1.3	1.0	2.0	1.1	1.6
Comparative body size at age 10	0.1	0.2	0.4	0.6	0.3	-0.1	-0.2	-0.5
Number of full brothers	0.7	0.8	2.4	1.5	1.2	-0.1	0.4	0.3
Worry too long after embarrassment	0.4	0.7	2.0	-0.4	-0.4	-1.0	-0.6	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.3	-0.2	0.6	-0.7	-1.5	-0.7
Wheeze or whistling in the chest in last year	0.2	0.4	1.1	0.9	0.1	0.2	-1.1	-0.1
Number of children fathered	0.5	0.6	1.1	-0.6	0.2	-1.0	-0.7	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.0	0.8	0.9	0.2	0.2
Age at first live birth	2.0	3.5	6.0	2.4	-0.3	-2.4	-1.7	-1.7
Pulse wave peak to peak time	0.4	0.4	1.3	-0.0	0.5	0.3	0.8	1.1
Health satisfaction	1.2	1.6	3.5	0.5	-0.4	-1.9	-1.3	-1.6
Shortness of breath walking on level ground	0.3	0.4	0.8	0.5	-0.9	-0.7	-0.2	-0.7
Qualifications: College or University degree	0.3	0.9	2.1	0.2	0.2	-0.4	1.4	1.5
Eye problems/disorders: None of the above	1.2	1.4	2.6	-0.3	0.2	-1.6	-1.3	-1.6
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.6	-0.1	-0.1	0.2	-0.6
Emphysema/chronic bronchitis	1.5	1.6	2.5	1.1	-1.0	-1.0	-1.6	-1.6
Medication for pain relief, constipation, heartburn	0.5	0.9	1.8	-1.3	0.2	1.2	0.2	1.2
Neck or shoulder pain in last month	1.5	2.2	3.3	-0.3	1.8	-1.6	-1.6	-1.6
Medication: Blood pressure	0.6	1.0	1.3	-1.1	0.9	-0.9	-1.0	-1.1
Angina (self-reported)	0.2	0.3	0.6	-0.7	-0.8	-0.3	0.2	-0.5
Migraine (self-reported)	2.5	3.1	5.5	1.0	0.9	1.9	2.3	2.2
Medication: Ibuprofen	0.3	0.3	1.1	0.2	1.1	0.2	0.2	0.7
Medication: Allopurinol	0.6	0.9	1.4	-1.2	-0.8	-1.1	-0.5	-0.9
Medication: Omeprazole	0.8	1.0	2.5	0.6	0.3	1.3	1.6	0.5
Medication: Seretide 50 evohaler	0.8	1.0	2.2	1.1	-1.1	-0.4	-1.5	-0.2
Mean time to correctly identify matches	0.7	1.3	2.6	1.0	-0.1	-1.6	-1.1	-1.3
Heart disease (mother)	0.3	0.3	1.0	-0.7	-1.0	0.1	0.1	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.8	0.6	1.3	0.9	-0.1	0.0
Whole body fat mass	0.3	1.3	3.3	1.8	0.1	0.3	0.5	1.7
Leg fat mass (right)	0.3	1.2	4.4	2.1	-0.2	-0.2	-0.1	1.2
Arm predicted mass (right)	0.3	1.5	2.6	1.6	1.5	0.4	0.4	1.5
Pulse rate, automated reading	0.1	0.2	1.0	-0.2	0.3	1.0	0.1	0.2
Alcohol intake frequency.	1.0	2.3	4.5	1.6	0.8	2.1	1.2	1.6
Comparative height size at age 10	0.7	4.1	12.7	2.3	3.6	-0.1	-1.0	-1.1
Number of full sisters	0.4	0.5	1.0	-0.8	-0.2	-0.8	-0.4	-1.0
Suffer from ‘nerves’	0.6	1.0	2.1	0.1	0.8	-0.8	-1.2	-1.4
Overall health rating	0.4	0.8	1.4	1.2	-0.2	-0.3	-1.0	-1.2
Chest pain or discomfort	0.8	1.2	3.9	-0.5	-2.0	-0.7	-0.8	-0.8
Had major operations	0.2	0.2	0.6	-0.8	-0.4	0.3	0.3	0.3
Age at last live birth	1.6	2.3	3.7	1.7	0.0	-1.7	-1.3	-1.9
Family relationship satisfaction	0.3	0.4	1.0	-1.0	-0.4	-0.6	-0.5	-0.3
Leg pain on walking	0.4	0.5	1.1	1.1	-0.4	-0.8	0.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.7	7.1	0.1	-0.6	-1.8	-2.7	-1.7
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.2	1.5	0.7	0.3	1.3	0.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.8	0.3	-0.3	-1.4	-1.7	-1.3
Medication: Aspirin	0.5	0.7	1.7	-0.0	-1.1	-0.4	-0.6	-1.3
Supplements: Vitamin C	0.4	0.5	1.0	0.8	-0.2	-1.0	-0.2	-0.9
Knee pain experienced in last month	0.6	0.9	1.4	1.0	0.8	-0.9	-0.9	-1.2
Hypertension (Self-reported)	0.8	2.1	2.9	0.5	1.7	1.7	1.5	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.7	0.8	0.4	0.8	0.8	0.3
Illnesses of father: Heart disease	0.4	0.5	1.1	0.1	-0.1	0.9	0.8	1.0
Illnesses of siblings: Diabetes	0.3	0.4	0.9	-0.4	-0.4	-0.5	-0.8	-1.0
Smoking status: Previous	1.3	2.0	4.0	0.7	1.3	2.0	1.9	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.9	1.7	1.2	-0.8	-0.4	-0.4
Whole body fat-free mass	0.3	1.9	4.4	2.1	1.6	0.2	0.5	1.6
Leg fat-free mass (right)	0.4	2.2	6.2	2.5	1.0	-0.2	0.6	1.9
Arm fat percentage (left)	0.5	2.1	4.5	1.8	-1.1	0.4	1.1	2.1
Average weekly red wine intake	0.9	1.3	3.8	-2.0	0.2	-1.3	-0.3	-0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	-0.8	0.2	0.8	1.3	0.4
Mood swings	1.0	1.8	5.7	-2.4	-0.4	0.9	-0.9	-1.2
Loneliness, isolation	0.5	0.7	1.5	1.2	-0.2	0.2	-1.1	-0.8
Long-standing illness, disability or infirmity	0.0	0.1	0.1	-0.3	0.3	0.3	0.2	0.0
Ever had bowel cancer screening	2.8	3.3	6.7	-0.3	2.6	1.3	2.2	1.8
Diabetes diagnosed by doctor	0.3	0.5	0.8	-0.8	-0.7	0.9	0.6	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.1	0.8	1.8	0.9	-0.1	-0.6
Friendships satisfaction	0.5	0.6	1.4	0.7	1.2	-0.4	-0.6	-0.7
Qualifications: nursing, teaching	1.7	2.7	6.6	-0.5	0.8	0.8	2.6	2.3
Commuting to job workplace: Walk	0.6	0.6	1.8	-0.9	-1.3	0.1	0.7	0.4
Eye problems/disorders: Cataract	2.3	2.7	6.4	0.3	0.7	1.7	1.9	2.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.6	-0.9	1.3	1.6	1.1	1.5
Medication for cholesterol	2.1	3.2	6.8	-0.2	-1.0	-2.6	-2.1	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	-1.0	0.5	-0.6	0.2	-0.1
Back pain experienced in last month	1.3	2.0	8.1	0.8	2.9	-0.2	-0.9	-0.2
Mineral and other dietary supplements	1.7	2.2	5.0	2.0	0.1	0.3	1.4	2.2
Breast cancer (self-reported)	0.9	1.0	2.7	-1.6	0.4	-1.3	-0.4	-0.6
Asthma (self-reported)	0.2	0.5	1.1	0.3	-0.6	-0.5	-0.8	-1.1
Osteoporosis (self-reported)	1.7	2.1	5.4	0.3	0.8	1.8	2.3	1.0
Osteoarthritis (self-reported)	0.4	0.5	1.7	1.3	-0.2	-0.2	0.6	-0.3
Medication: Aspirin	0.2	0.3	0.7	-0.4	-0.8	0.1	-0.1	-0.8
Medication: Gliclazide	0.6	0.6	1.3	-0.3	-0.7	-1.1	-1.1	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.5	0.8	-0.3	0.0	-0.3
Smoking status: Current	3.2	5.1	17.9	-1.2	-1.1	-1.0	-4.2	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.0	0.7	0.3	-1.4	-1.1	-1.2
Whole body water mass	0.3	1.8	3.8	1.9	1.6	0.1	0.4	1.5
Leg predicted mass (right)	0.4	2.3	6.3	2.5	1.0	-0.2	0.6	1.9
Arm fat mass (left)	0.5	2.1	5.0	2.1	-0.4	0.5	1.0	2.2
Number of self-reported non-cancer illnesses	1.3	2.3	4.5	0.5	1.0	1.8	2.1	1.5
Average weekly champagne plus white wine intake	0.3	0.4	1.7	0.0	-0.5	0.0	-0.1	-1.3
Miserableness	1.3	2.3	7.8	-2.8	-0.7	-0.1	-1.4	-1.1
Guilty feelings	0.1	0.1	0.3	-0.5	0.3	-0.3	-0.4	0.0
Wears glasses or contact lenses	1.1	1.2	3.3	-1.8	-1.1	-0.2	-0.8	-0.9
Ever taken oral contraceptive pill	0.3	0.4	0.8	-0.4	0.4	-0.7	-0.9	-0.5
Hearing aid user	0.2	0.2	0.8	0.9	-0.1	0.4	-0.1	-0.3
Mother’s age at death	0.5	0.7	1.2	1.0	-0.1	-0.0	1.1	1.1
Financial situation satisfaction	1.6	2.0	4.1	-0.1	-2.0	-1.7	-1.0	-1.4
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.9	-2.0	0.0	0.0	0.1	-0.7
Commuting to job workplace: Public transport	1.2	1.5	3.8	0.4	2.0	-1.2	-0.7	-1.2
Eye problems/disorders: Glaucoma	1.1	1.3	4.7	0.6	2.2	1.1	0.4	0.1
Medication: Blood pressure	0.7	1.3	2.3	1.5	0.3	1.0	1.5	1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.6	1.1	1.2	0.4	-0.4	0.1
Supplements: Fish oil (including cod liver oil)	1.9	2.5	7.0	-0.8	-0.8	-0.9	-1.9	-2.6
High cholesterol (Self-reported)	0.3	0.5	1.1	0.1	0.1	0.7	1.0	1.0
Medication: Bendroflumethiazide	1.8	2.7	3.9	1.9	2.0	1.8	1.2	1.2
Medication: Paracetamol	0.5	0.8	1.6	1.2	1.3	-0.6	-0.1	-0.8
Medication: Lisinopril	0.5	0.6	1.1	-0.7	-0.8	1.1	-0.8	0.1
Medication: Atorvastatin	2.4	2.9	4.1	-1.3	-1.4	-1.9	-1.7	-2.0
Illnesses of father: High blood pressure	0.1	0.1	0.4	0.1	-0.5	-0.6	0.1	-0.0
Alcohol drinker status: Never	0.4	0.5	1.7	-0.3	-0.8	1.3	0.5	0.0
Ever smoked	0.3	0.5	0.8	-0.9	0.8	0.6	-0.6	-0.7
Basal metabolic rate	0.4	2.0	4.8	2.2	1.3	0.1	0.5	1.7
Leg fat percentage (left)	0.3	1.1	3.7	1.9	-0.9	-0.2	-0.2	1.0
Arm fat-free mass (left)	0.3	1.6	3.8	1.9	1.4	0.2	0.2	1.5
Number of operations (self-reported)	0.9	1.4	3.6	-0.8	0.0	1.5	1.9	0.6
Average weekly beer plus cider intake	0.9	1.3	3.4	0.6	-0.2	-1.3	-1.8	-1.0
Irritability	3.1	5.2	10.5	-2.0	-0.1	-1.5	-3.1	-3.2
Risk taking	0.8	1.2	2.7	0.8	-1.6	-0.8	-1.1	-0.8
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.1	1.4	1.3	-0.1	1.3	0.3
Fractured/broken bones in last 5 years	0.9	1.1	2.5	-1.1	-1.6	1.2	0.6	0.3
Age started oral contraceptive pill	0.9	1.1	1.7	1.3	1.0	0.8	1.1	1.0
Diastolic blood pressure, automated reading	0.7	2.2	7.3	2.7	0.9	0.7	-0.3	1.5
Ever depressed for a whole week	0.5	0.6	1.6	-0.2	-0.3	-0.9	-0.5	-1.3
Unable to work because of sickness or disability	0.2	0.2	0.6	0.7	0.6	-0.1	-0.3	-0.3
Commuting to job workplace: Cycle	0.5	0.6	2.2	-0.7	1.5	-0.4	-0.3	-0.3
Myopia	0.7	1.0	3.1	-0.9	1.1	0.0	0.2	1.8
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.1	-0.4	-1.4	-0.7	-0.6	-0.6
Cholesterol lowering medication	0.4	0.6	0.9	0.8	0.0	0.9	0.9	0.9
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	3.7	0.7	0.8	1.9	1.9	1.3
Pain experienced in last month	0.7	1.2	3.3	-1.7	-1.8	0.3	0.2	0.3
Supplements: Calcium	2.5	2.8	3.7	-1.9	1.3	1.8	1.9	1.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.5	0.2	0.6	0.4	0.0
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.6	-0.7	-0.8	-1.9	-1.2	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.4	-0.0	1.2	0.7	0.8	0.6
Heart disease (siblings)	0.8	1.0	2.5	-0.3	0.0	-0.5	-1.6	-1.4
Alcohol drinker status: Previous	0.4	0.5	0.8	0.6	-0.9	0.9	-0.6	-0.4
Pack years of smoking	0.3	0.4	1.7	0.1	0.6	1.3	0.0	0.1
Impedance of whole body	0.2	1.2	2.7	-1.4	0.7	0.5	-0.6	-1.6
Leg fat mass (left)	0.4	1.4	5.4	2.3	-0.2	-0.3	-0.1	1.2
Arm predicted mass (left)	0.4	2.2	4.2	2.0	1.5	0.7	0.6	1.9