Hub : Genes

TXNDC12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0490 0.0310 1.3e-02 -0.001 0.006 0.002 0.007 -0.002 5.2e-01 5.8e-02 1.7e-01 4.7e-02 5.8e-01
2 GTEx Skin Not Sun Exposed Suprapubic 0.1200 0.0560 4.1e-03 0.006 NA 0.027 NA 0.017 1.4e-01 NA 1.2e-02 NA 3.7e-02
3 GTEx Whole Blood 0.1290 0.0600 3.8e-04 0.042 NA 0.076 NA 0.076 8.7e-05 NA 1.8e-07 NA 1.7e-07
4 ROSMAP Brain Pre-frontal Cortex 0.0768 0.0361 1.5e-02 0.051 0.000 0.045 0.029 0.038 3.2e-07 3.1e-01 1.8e-06 9.9e-05 9.7e-06
5 YFS Blood 0.1734 0.0411 4.5e-13 0.076 0.047 0.066 0.075 0.074 7.9e-24 5.0e-15 7.5e-21 1.7e-23 5.2e-23

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.0 1.5 4.2 -2.0 -0.8 0.4 1.5 0.6
Bipolar Disorder or Schizophrenia 0.2 0.4 0.8 -0.4 -0.6 0.8 0.9 0.1
Depressed Affect (Nagel 2018) 0.7 1.4 2.4 -1.6 -0.9 0.4 -1.5 -1.2
Depression (Nagel 2018) 0.3 0.4 0.8 -0.9 -0.8 0.7 -0.1 -0.3
Intelligence (Savage-Jansen 2018) 1.1 3.3 15.3 -3.9 -0.7 0.7 -0.5 0.0
Neuroticism (Nagel 2018) 1.2 2.7 4.9 -1.5 -1.0 -0.7 -2.2 -2.2
Schizophrenia (2018) 0.2 0.4 0.7 0.8 -0.3 0.1 -0.6 -0.9
Schizophrenia vs Biploar Disorder 0.8 1.0 2.0 1.4 -0.1 1.2 0.9 0.9
Worry (Nagel 2018) 0.8 1.6 4.0 -0.0 0.4 -0.8 -1.8 -2.0
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 0.2 -0.1 0.2 -0.0 -0.2
Alzheimer’s Disease (in father) 1.6 1.7 4.2 -0.1 0.7 1.3 2.1 1.5
Alzheimer’s Disease (including proxy) 0.3 0.5 0.7 -0.6 -0.3 0.8 0.8 0.7
Crohns Disease (2017) 1.5 3.2 7.8 1.5 -0.4 1.3 2.8 2.0
Irritable Bowel Disease (IBD) 1.3 3.0 8.4 2.9 -0.9 0.5 2.0 1.2
Ulcerative Colitis (UC) 1.2 2.2 10.2 3.2 -0.8 -0.2 0.4 0.2
Major Depression (MDD) 1.1 1.3 5.1 -2.3 -0.2 -0.1 -0.6 -1.0
Reaction Time 0.9 1.8 2.9 1.0 -1.0 -1.7 -1.4 -1.5
Verbal and Numeric Reasoning (VNR) 1.4 3.5 16.7 -4.1 -0.4 0.3 -0.4 -0.4
Breast Cancer 1.0 2.3 4.5 0.4 -0.8 2.1 1.6 1.9
Ovarian Cancer 1.5 1.9 4.2 -0.8 1.1 2.0 1.6 1.1
Prostate Cancer 0.9 1.3 3.5 1.9 -0.3 -1.0 -0.9 -1.2
Age at First Birth 1.4 2.1 5.4 1.8 2.3 -0.3 1.0 0.8
Bipolar Disorder (2011) 0.2 0.2 0.5 -0.5 0.4 0.0 0.0 -0.7
Body Mass Index (BMI) (2010) 0.2 0.3 0.7 0.7 -0.4 0.2 0.4 0.8
Coronary Artery Disease (CAD) 0.4 0.5 1.0 -0.2 -1.0 0.5 0.7 0.9
Crohns Disease (2012) 2.5 4.1 6.5 2.3 0.6 1.6 2.5 2.4
Mean Putamen Volume 1.7 2.0 8.9 -3.0 -1.0 0.2 -0.3 0.1
Fasting Glucose 1.3 1.6 6.7 2.6 -0.7 0.4 0.2 0.8
HbA1C 1.1 1.2 3.8 -0.3 -2.0 0.4 -1.3 -0.6
HDL Cholesterol 0.2 0.3 1.0 0.4 -0.4 -0.6 -1.0 -0.1
LDL Cholesterol 0.7 1.1 4.0 -2.0 -0.2 1.0 0.3 -0.3
Lupus 2.8 4.2 8.4 -1.2 -1.1 -1.6 -2.8 -2.9
Neuroticism (2016) 1.1 1.6 3.0 -1.2 -0.6 -1.1 -1.4 -1.7
Primary Biliary Cirrhosis 0.1 0.2 0.6 -0.8 -0.4 -0.1 -0.4 -0.2
Rheumatoid Arthritis 0.6 0.9 1.9 0.3 0.9 1.0 1.4 0.8
Schizophrenia (2014) 0.1 0.1 0.5 0.0 -0.7 0.4 -0.1 -0.2
Triglycerides 0.7 1.1 1.7 -1.1 0.9 1.2 1.3 0.4
Type 2 Diabetes (T2D) (2012) 0.9 1.0 1.6 -0.3 -1.1 -1.3 -0.7 -1.3
Ulcerative Colitis 1.5 2.2 10.6 3.3 0.2 -0.4 0.4 -0.0
Blood Eosinophil Count 0.1 0.5 1.7 1.3 -0.5 -0.3 -0.7 0.4
Blood Platelet Count 0.2 2.0 4.5 -1.9 -1.1 2.1 0.6 -0.1
Blood Red Count 0.5 5.2 10.2 1.7 1.9 2.1 2.1 3.2
Blood White Count 0.2 1.8 6.1 1.4 -2.5 -0.8 -0.6 0.2
Heel T-Score 0.8 6.7 18.1 -4.2 -1.6 -1.7 -2.4 -2.0
BMI 0.4 2.4 6.1 2.0 -1.3 -0.2 0.5 2.5
Height 0.6 10.6 43.4 2.6 6.6 1.0 1.2 0.7
Waist Hip Ratio (WHR) 0.1 0.5 0.9 -1.0 0.9 0.5 -0.1 -0.7
Systolic Blood Pressure 0.2 1.0 4.4 -0.4 2.1 0.5 -0.1 0.3
Smoking Status 0.5 1.1 4.5 -0.3 0.2 0.9 -2.1 -0.4
Allergy or Eczema 0.2 0.5 1.0 -0.7 0.6 0.7 1.0 0.0
Cardiovascular Disease 0.2 0.8 1.8 0.7 0.4 0.8 0.9 1.3
Hypothyroidism (self reported) 0.6 1.5 2.2 0.9 1.1 1.5 1.3 1.2
Respiratory disease 0.4 0.8 1.5 1.2 -0.5 -0.7 -0.7 -1.1
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.4 -1.0 -1.5 -0.1 -0.1 0.2
Lung FEV1/FVC ratio 0.0 0.2 0.5 0.7 -0.1 0.1 -0.6 -0.4
Lung FVC 0.2 0.9 3.0 -0.5 1.7 -0.8 0.5 -0.5
Neuroticism 1.1 2.7 7.6 -0.7 0.3 -1.2 -1.9 -2.8
Chronotype (morning person) 0.7 1.7 3.4 -0.1 -0.4 1.8 1.6 1.5
Hair Pigment 0.0 0.9 2.9 1.7 -0.7 -1.0 -0.0 0.1
Tanning 0.1 0.7 1.6 1.3 0.7 0.8 -0.3 0.8
Hand grip strength (left) 0.2 0.6 2.0 0.1 -0.0 -0.9 -1.4 -0.3
Number of treatments/medications taken 0.1 0.1 0.5 -0.1 0.4 -0.2 0.7 -0.2
Average weekly spirits intake 0.7 0.8 2.0 0.9 1.4 -1.0 0.2 -0.3
Sensitivity / hurt feelings 0.6 1.1 2.0 -0.6 1.2 -0.8 -1.0 -1.4
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.3 -1.5 -1.3 0.1 -0.5 -0.6
Hearing difficulty/problems: Yes 1.5 2.3 4.2 -1.0 2.1 -1.2 -1.3 -1.8
Relative age of first facial hair 0.5 1.0 3.9 -2.0 -0.3 -0.8 0.6 -0.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.8 -0.5 1.3 -0.0 0.6 0.2
Ever used hormone-replacement therapy (HRT) 0.9 1.1 5.2 -0.4 0.3 2.3 0.3 -0.0
Ever had hysterectomy (womb removed) 1.0 1.2 2.4 -1.6 -0.4 -0.7 -1.2 -1.2
Systolic blood pressure, automated reading 0.2 0.6 1.4 -0.6 1.2 0.8 -0.1 0.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.4 -0.4 0.2 0.3 0.6 0.4
Angina 0.3 0.3 0.6 -0.6 -0.7 -0.5 -0.0 -0.8
Medication for hormone replacement therapy 2.4 2.7 6.9 0.2 1.4 2.6 1.8 1.1
Vitamin and mineral supplements 0.6 0.9 2.7 0.9 -0.1 0.5 0.8 1.6
Supplements: Zinc 0.2 0.3 0.7 -0.2 0.8 -0.1 -0.7 -0.3
Medication: Co-codamol 0.4 0.5 1.1 -0.3 -1.1 -0.9 0.1 -0.6
Medication: Metformin 0.2 0.2 0.7 0.5 -0.8 -0.4 -0.1 -0.2
Diabetes (father) 1.2 1.5 5.3 -2.3 0.8 1.3 0.2 -0.0
Diabetes (mother) 0.6 0.7 2.1 0.8 -0.6 0.8 -1.4 0.3
Severe depression (siblings) 2.7 3.1 6.5 -0.4 -0.8 -2.6 -2.0 -2.0
Pack years adult smoking proportion 0.2 0.3 0.8 -0.3 -0.1 0.9 -0.7 -0.4
Impedance of leg (right) 0.6 3.1 7.7 -2.1 0.3 -0.1 -1.8 -2.8
Leg fat-free mass (left) 0.4 2.0 6.1 2.5 0.9 -0.1 0.5 1.7
Trunk fat percentage 0.3 1.1 2.8 1.7 -0.2 0.4 0.6 1.5
Hand grip strength (right) 0.1 0.3 0.6 0.1 0.6 0.8 -0.2 0.6
Townsend deprivation index at recruitment 0.2 0.2 0.6 -0.8 0.4 0.4 -0.3 -0.3
Current tobacco smoking 2.8 4.5 16.3 -0.6 -1.2 -1.1 -4.0 -1.8
Average weekly fortified wine intake 0.9 1.0 2.9 1.0 1.7 -0.6 0.1 -0.9
Maternal smoking around birth 0.9 1.3 5.2 -2.3 0.5 0.0 -1.0 -0.3
Fed-up feelings 0.9 1.6 3.9 -0.8 -0.9 -0.5 -2.0 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 3.8 -0.2 0.2 2.0 1.3 1.3
Relative age voice broke 1.4 2.1 5.5 -2.4 2.1 0.2 0.6 -0.1
Taking other prescription medications 0.2 0.3 0.6 0.3 0.3 0.6 0.8 0.4
Age when periods started (menarche) 0.7 1.7 6.7 -2.6 -0.4 0.7 0.6 0.8
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 3.9 -2.0 0.1 -0.7 -0.4 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.8 -0.9 -0.3 -0.5 0.2 0.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 0.9 -0.7 0.2 0.5 0.4 0.9
Qualifications: CSEs or equivalent 1.2 1.6 2.3 -0.7 -1.4 -1.4 -1.2 -1.5
Serious illness, injury or assault to yourself 0.4 0.5 1.9 0.2 1.4 -0.4 0.6 -0.1
High blood pressure 0.4 1.0 2.4 0.4 1.6 1.0 0.6 0.9
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.3 -0.0 1.1 0.7 1.0 0.1
Multivitamins +/- minerals 0.3 0.4 0.8 -0.3 0.8 0.3 -0.8 -0.9
Stomach or abdominal pain in last month 0.2 0.3 0.6 -0.8 0.7 0.2 0.5 -0.1
Supplements: Glucosamine 1.5 1.9 3.4 -1.8 0.1 -1.1 -1.3 -1.8
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 4.0 -1.9 -2.0 0.5 -0.1 0.5
Medication: Atenolol 1.4 1.7 3.2 1.5 1.8 0.3 1.6 0.5
Medication: Levothyroxine sodium 0.6 1.1 1.8 0.8 0.6 1.4 1.0 1.2
Sitting height 0.3 2.0 7.5 1.1 2.7 0.7 -0.4 0.7
Chronic bronchitis/emphysema (father) 0.0 0.0 0.0 0.1 0.1 0.2 -0.0 0.1
High blood pressure (mother) 1.1 1.6 3.7 0.6 0.0 1.4 1.4 1.9
Body mass index (BMI) 0.6 2.4 5.2 2.1 -1.4 0.1 0.7 2.3
Impedance of leg (left) 0.5 2.4 6.1 -1.6 0.7 -0.0 -1.7 -2.5
Leg predicted mass (left) 0.4 1.9 5.9 2.4 0.9 -0.2 0.4 1.6
Trunk fat mass 0.4 1.6 4.4 2.1 0.4 0.4 0.8 1.7
Waist circumference 0.2 0.8 2.7 1.6 0.3 -0.0 0.2 1.2
Number of incorrect matches in round 0.4 0.7 2.4 -0.3 0.8 -0.7 0.2 -1.5
Past tobacco smoking 0.4 0.8 1.8 0.8 -0.8 -1.4 0.4 0.7
Alcohol usually taken with meals 0.5 0.7 2.1 -1.0 1.4 0.0 0.8 0.4
Nervous feelings 0.3 0.6 1.1 0.1 1.0 -0.6 -1.0 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.2 2.1 -0.7 -0.9 -0.5 -1.4 -1.5
Hearing difficulty/problems with background noise 0.9 1.4 3.1 -0.8 1.8 -1.0 -0.6 -1.4
Hair/balding pattern: Pattern 2 0.5 0.6 1.9 -0.2 -0.8 -0.4 -1.4 -0.4
Had menopause 1.4 1.7 6.5 -0.0 2.5 1.2 -0.2 -0.7
Had other major operations 0.4 0.5 1.2 0.1 0.7 0.9 1.1 0.4
Forced vital capacity (FVC) 0.5 1.9 7.3 0.9 2.7 0.8 0.4 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.3 -1.0 -1.2 -1.5 -0.7 -1.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.0 -1.0 -0.8 -0.5 -0.6 0.0
Qualifications: None of the above 0.5 1.0 3.3 0.5 0.2 1.8 0.7 1.0
Financial difficulties in last 2 years 0.8 1.1 3.2 -1.8 -1.4 -0.1 -0.0 -0.6
Mouth/teeth dental problems 0.3 0.4 1.3 0.2 -0.0 -0.5 1.1 0.7
Heart attack 1.5 1.9 4.6 -0.3 -0.6 -2.1 -1.5 -1.4
Allergy 0.1 0.3 0.6 -0.4 -0.6 -0.8 -0.4 0.4
Pain all over the body in last month 0.7 0.8 1.9 0.4 1.4 1.1 0.5 0.5
Diabetes (self-reported) 0.7 1.1 2.0 -1.2 -0.1 1.4 1.0 1.1
Hayfever/allergic rhinitis (self-reported) 2.3 3.0 5.6 2.0 -0.0 0.9 2.2 2.4
Medication: Ramipril 0.6 0.8 2.3 -0.0 -0.2 -0.5 -1.5 -1.1
Medication: Simvastatin 0.5 0.7 1.4 0.7 0.2 1.2 0.9 0.9
Fluid intelligence score 1.0 2.1 9.3 -3.1 0.6 0.9 -0.0 0.0
Illnesses of siblings 1.0 1.4 2.5 0.5 0.6 1.2 1.4 1.6
Neuroticism score 0.9 2.0 5.0 -0.7 0.4 -0.8 -1.9 -2.2
Weight 0.5 2.3 6.4 2.5 0.7 0.3 0.6 2.0
Impedance of arm (right) 0.1 0.6 2.2 -0.2 0.5 -0.1 -0.5 -1.5
Arm fat percentage (right) 0.5 2.0 4.3 2.1 -1.2 0.2 0.8 1.9
Trunk fat-free mass 0.3 1.7 3.8 1.7 1.9 0.4 0.4 1.4
Hip circumference 0.4 1.8 6.8 2.6 -0.0 -0.7 -0.1 1.2
Time employed in main current job 0.3 0.3 0.8 0.8 0.0 0.5 -0.3 0.9
Alcohol intake versus 10 years previously 0.4 0.6 2.1 0.0 -0.1 0.7 0.4 1.4
Father’s age at death 0.4 0.5 1.9 -0.0 0.0 -1.4 -0.3 -0.8
Worrier / anxious feelings 0.1 0.3 1.2 0.3 1.1 -0.0 -0.0 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.9 -0.5 0.0 1.4 -0.5 0.3
Falls in the last year 1.5 2.0 5.7 0.4 0.3 -1.0 -2.4 -1.8
Hair/balding pattern: Pattern 3 0.2 0.4 0.7 0.8 -0.8 -0.5 0.5 0.2
Number of live births 0.1 0.2 0.5 0.7 0.3 -0.1 0.0 -0.4
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 4.4 0.7 2.1 0.3 0.5 0.4
Pulse rate 0.9 1.6 4.7 -2.2 0.6 1.6 0.1 0.3
Happiness 1.1 1.3 2.3 1.1 -0.4 -1.5 -0.8 -1.5
Noisy workplace 1.6 2.0 4.5 -0.2 -2.1 -1.6 -1.2 -1.1
Qualifications: A levels/AS levels or equivalent 0.5 1.0 2.2 0.3 1.0 0.0 1.5 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.3 -0.1 0.7 0.9 1.8 0.8
Mouth/teeth dental problems: Dentures 0.5 0.8 1.6 0.3 -1.2 0.2 -1.3 -0.9
Asthma 0.3 0.5 1.0 0.1 -0.7 -0.4 -0.9 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.6 1.8 0.6 1.3 0.1 0.3 0.7
Medication: Cholesterol lowering 0.1 0.1 0.2 -0.4 -0.4 0.2 0.5 0.2
Depression (self-reported) 0.9 1.0 2.3 -1.3 0.4 -0.5 -0.9 -1.5
Medication: Lansoprazole 1.0 1.1 2.2 -0.7 0.3 1.5 1.3 1.1
Prospective memory result 0.7 0.9 2.0 -0.1 -0.1 -0.5 -1.4 -1.4
Lung cancer (father) 0.7 0.8 2.8 -0.2 1.7 0.9 0.6 -0.3
Illnesses of mother 0.7 0.8 1.8 1.1 1.4 0.1 1.1 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 3.5 0.8 1.9 0.4 0.7 0.5
Pulse wave Arterial Stiffness index 0.4 0.4 1.4 0.2 -0.2 -0.3 -0.7 -1.2
Impedance of arm (left) 0.1 0.5 0.8 -0.7 0.9 0.8 0.5 -0.6
Arm fat mass (right) 0.5 2.1 5.0 2.2 -0.5 0.3 0.8 2.1
Trunk predicted mass 0.3 1.7 3.7 1.7 1.9 0.4 0.4 1.3
Standing height 0.4 4.3 19.8 1.2 4.5 0.7 0.0 -0.1
Length of working week for main job 0.8 0.9 2.8 -1.0 -1.7 -0.1 -0.9 -0.0
Exposure to tobacco smoke at home 1.2 1.4 2.6 -0.8 -0.9 -0.7 -1.5 -1.6
Breastfed as a baby 1.1 1.3 4.3 -0.7 0.1 0.9 2.1 1.0
Tense / ‘highly strung’ 1.5 2.4 5.2 0.7 -0.3 -1.3 -2.1 -2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 16.2 -4.0 0.9 0.8 -0.3 -0.6
Hair/balding pattern: Pattern 4 0.2 0.5 0.9 -0.3 -0.7 1.0 0.7 0.9
Birth weight of first child 0.1 0.3 0.8 -0.2 0.1 0.7 0.1 0.9
Peak expiratory flow (PEF) 0.4 0.9 4.1 0.2 2.0 0.5 0.4 0.3
Pulse wave reflection index 1.6 1.9 8.0 2.8 1.2 -0.5 0.1 -0.1
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.5 0.2 1.1 -1.2 0.1 -0.3
Loud music exposure frequency 1.5 1.6 3.8 -1.7 -1.0 -0.7 -1.9 -0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.1 -1.1 0.6 -0.9 0.2 0.0
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.2 -0.6 -1.1 0.3 -0.8 0.1
Blood clot in the leg (DVT) 0.6 0.8 1.4 -0.2 1.2 0.9 1.1 0.8
Medication: Paracetamol 1.1 1.8 4.0 2.0 1.4 -1.0 -0.4 -1.3
Headache pain in last month 0.6 1.1 4.7 2.2 0.5 -0.7 0.2 -0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.0 1.0 -0.2 0.3 0.3 0.4
Glaucoma (self-reported) 0.4 0.5 0.9 -0.2 0.9 0.8 0.9 0.3
Gout (self-reported) 0.6 0.8 3.1 -1.8 -0.6 0.4 0.5 0.2
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 3.2 0.7 1.3 1.8 1.2 1.3
Medication: Amlodipine 0.3 0.5 1.7 -1.3 0.4 0.0 0.7 0.1
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.0 0.3 -0.3 -1.4 -1.7 -1.1
Birth weight 0.2 0.5 0.9 0.6 0.8 0.4 1.0 0.8
Chronic bronchitis/emphysema (mother) 1.3 1.5 3.5 -1.9 -0.8 -1.3 -0.5 -1.3
High blood pressure (siblings) 0.8 1.2 2.3 -0.1 0.7 -1.4 -1.5 -1.1
Forced vital capacity (FVC), Best measure 0.4 1.5 6.2 0.6 2.5 0.5 0.8 0.5
Body fat percentage 0.3 1.1 2.8 1.7 -0.4 0.4 0.5 1.5
Leg fat percentage (right) 0.2 0.7 2.2 1.5 -0.9 -0.1 -0.3 0.8
Arm fat-free mass (right) 0.3 1.7 2.8 1.6 1.5 0.5 0.7 1.7
Exposure to tobacco smoke outside home 1.6 2.1 4.1 -1.3 1.0 2.0 1.1 1.6
Comparative body size at age 10 0.1 0.2 0.4 0.6 0.3 -0.1 -0.2 -0.5
Number of full brothers 0.7 0.8 2.4 1.5 1.2 -0.1 0.4 0.3
Worry too long after embarrassment 0.4 0.7 2.0 -0.4 -0.4 -1.0 -0.6 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.3 -0.2 0.6 -0.7 -1.5 -0.7
Wheeze or whistling in the chest in last year 0.2 0.4 1.1 0.9 0.1 0.2 -1.1 -0.1
Number of children fathered 0.5 0.6 1.1 -0.6 0.2 -1.0 -0.7 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.7 -0.0 0.8 0.9 0.2 0.2
Age at first live birth 2.0 3.5 6.0 2.4 -0.3 -2.4 -1.7 -1.7
Pulse wave peak to peak time 0.4 0.4 1.3 -0.0 0.5 0.3 0.8 1.1
Health satisfaction 1.2 1.6 3.5 0.5 -0.4 -1.9 -1.3 -1.6
Shortness of breath walking on level ground 0.3 0.4 0.8 0.5 -0.9 -0.7 -0.2 -0.7
Qualifications: College or University degree 0.3 0.9 2.1 0.2 0.2 -0.4 1.4 1.5
Eye problems/disorders: None of the above 1.2 1.4 2.6 -0.3 0.2 -1.6 -1.3 -1.6
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.4 -0.6 -0.1 -0.1 0.2 -0.6
Emphysema/chronic bronchitis 1.5 1.6 2.5 1.1 -1.0 -1.0 -1.6 -1.6
Medication for pain relief, constipation, heartburn 0.5 0.9 1.8 -1.3 0.2 1.2 0.2 1.2
Neck or shoulder pain in last month 1.5 2.2 3.3 -0.3 1.8 -1.6 -1.6 -1.6
Medication: Blood pressure 0.6 1.0 1.3 -1.1 0.9 -0.9 -1.0 -1.1
Angina (self-reported) 0.2 0.3 0.6 -0.7 -0.8 -0.3 0.2 -0.5
Migraine (self-reported) 2.5 3.1 5.5 1.0 0.9 1.9 2.3 2.2
Medication: Ibuprofen 0.3 0.3 1.1 0.2 1.1 0.2 0.2 0.7
Medication: Allopurinol 0.6 0.9 1.4 -1.2 -0.8 -1.1 -0.5 -0.9
Medication: Omeprazole 0.8 1.0 2.5 0.6 0.3 1.3 1.6 0.5
Medication: Seretide 50 evohaler 0.8 1.0 2.2 1.1 -1.1 -0.4 -1.5 -0.2
Mean time to correctly identify matches 0.7 1.3 2.6 1.0 -0.1 -1.6 -1.1 -1.3
Heart disease (mother) 0.3 0.3 1.0 -0.7 -1.0 0.1 0.1 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.8 0.6 1.3 0.9 -0.1 0.0
Whole body fat mass 0.3 1.3 3.3 1.8 0.1 0.3 0.5 1.7
Leg fat mass (right) 0.3 1.2 4.4 2.1 -0.2 -0.2 -0.1 1.2
Arm predicted mass (right) 0.3 1.5 2.6 1.6 1.5 0.4 0.4 1.5
Pulse rate, automated reading 0.1 0.2 1.0 -0.2 0.3 1.0 0.1 0.2
Alcohol intake frequency. 1.0 2.3 4.5 1.6 0.8 2.1 1.2 1.6
Comparative height size at age 10 0.7 4.1 12.7 2.3 3.6 -0.1 -1.0 -1.1
Number of full sisters 0.4 0.5 1.0 -0.8 -0.2 -0.8 -0.4 -1.0
Suffer from ‘nerves’ 0.6 1.0 2.1 0.1 0.8 -0.8 -1.2 -1.4
Overall health rating 0.4 0.8 1.4 1.2 -0.2 -0.3 -1.0 -1.2
Chest pain or discomfort 0.8 1.2 3.9 -0.5 -2.0 -0.7 -0.8 -0.8
Had major operations 0.2 0.2 0.6 -0.8 -0.4 0.3 0.3 0.3
Age at last live birth 1.6 2.3 3.7 1.7 0.0 -1.7 -1.3 -1.9
Family relationship satisfaction 0.3 0.4 1.0 -1.0 -0.4 -0.6 -0.5 -0.3
Leg pain on walking 0.4 0.5 1.1 1.1 -0.4 -0.8 0.6 -0.2
Qualifications: NVQ or HND or HNC or equivalent 2.3 2.7 7.1 0.1 -0.6 -1.8 -2.7 -1.7
Commuting to job workplace: Car/motor vehicle 0.9 1.0 2.2 1.5 0.7 0.3 1.3 0.7
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 2.8 0.3 -0.3 -1.4 -1.7 -1.3
Medication: Aspirin 0.5 0.7 1.7 -0.0 -1.1 -0.4 -0.6 -1.3
Supplements: Vitamin C 0.4 0.5 1.0 0.8 -0.2 -1.0 -0.2 -0.9
Knee pain experienced in last month 0.6 0.9 1.4 1.0 0.8 -0.9 -0.9 -1.2
Hypertension (Self-reported) 0.8 2.1 2.9 0.5 1.7 1.7 1.5 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.7 0.8 0.4 0.8 0.8 0.3
Illnesses of father: Heart disease 0.4 0.5 1.1 0.1 -0.1 0.9 0.8 1.0
Illnesses of siblings: Diabetes 0.3 0.4 0.9 -0.4 -0.4 -0.5 -0.8 -1.0
Smoking status: Previous 1.3 2.0 4.0 0.7 1.3 2.0 1.9 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.9 1.7 1.2 -0.8 -0.4 -0.4
Whole body fat-free mass 0.3 1.9 4.4 2.1 1.6 0.2 0.5 1.6
Leg fat-free mass (right) 0.4 2.2 6.2 2.5 1.0 -0.2 0.6 1.9
Arm fat percentage (left) 0.5 2.1 4.5 1.8 -1.1 0.4 1.1 2.1
Average weekly red wine intake 0.9 1.3 3.8 -2.0 0.2 -1.3 -0.3 -0.8
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.7 -0.8 0.2 0.8 1.3 0.4
Mood swings 1.0 1.8 5.7 -2.4 -0.4 0.9 -0.9 -1.2
Loneliness, isolation 0.5 0.7 1.5 1.2 -0.2 0.2 -1.1 -0.8
Long-standing illness, disability or infirmity 0.0 0.1 0.1 -0.3 0.3 0.3 0.2 0.0
Ever had bowel cancer screening 2.8 3.3 6.7 -0.3 2.6 1.3 2.2 1.8
Diabetes diagnosed by doctor 0.3 0.5 0.8 -0.8 -0.7 0.9 0.6 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 3.1 0.8 1.8 0.9 -0.1 -0.6
Friendships satisfaction 0.5 0.6 1.4 0.7 1.2 -0.4 -0.6 -0.7
Qualifications: nursing, teaching 1.7 2.7 6.6 -0.5 0.8 0.8 2.6 2.3
Commuting to job workplace: Walk 0.6 0.6 1.8 -0.9 -1.3 0.1 0.7 0.4
Eye problems/disorders: Cataract 2.3 2.7 6.4 0.3 0.7 1.7 1.9 2.5
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 2.6 -0.9 1.3 1.6 1.1 1.5
Medication for cholesterol 2.1 3.2 6.8 -0.2 -1.0 -2.6 -2.1 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.9 -1.0 0.5 -0.6 0.2 -0.1
Back pain experienced in last month 1.3 2.0 8.1 0.8 2.9 -0.2 -0.9 -0.2
Mineral and other dietary supplements 1.7 2.2 5.0 2.0 0.1 0.3 1.4 2.2
Breast cancer (self-reported) 0.9 1.0 2.7 -1.6 0.4 -1.3 -0.4 -0.6
Asthma (self-reported) 0.2 0.5 1.1 0.3 -0.6 -0.5 -0.8 -1.1
Osteoporosis (self-reported) 1.7 2.1 5.4 0.3 0.8 1.8 2.3 1.0
Osteoarthritis (self-reported) 0.4 0.5 1.7 1.3 -0.2 -0.2 0.6 -0.3
Medication: Aspirin 0.2 0.3 0.7 -0.4 -0.8 0.1 -0.1 -0.8
Medication: Gliclazide 0.6 0.6 1.3 -0.3 -0.7 -1.1 -1.1 -0.4
Illnesses of father: None of the above (group 1) 0.2 0.2 0.6 0.5 0.8 -0.3 0.0 -0.3
Smoking status: Current 3.2 5.1 17.9 -1.2 -1.1 -1.0 -4.2 -1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.0 0.7 0.3 -1.4 -1.1 -1.2
Whole body water mass 0.3 1.8 3.8 1.9 1.6 0.1 0.4 1.5
Leg predicted mass (right) 0.4 2.3 6.3 2.5 1.0 -0.2 0.6 1.9
Arm fat mass (left) 0.5 2.1 5.0 2.1 -0.4 0.5 1.0 2.2
Number of self-reported non-cancer illnesses 1.3 2.3 4.5 0.5 1.0 1.8 2.1 1.5
Average weekly champagne plus white wine intake 0.3 0.4 1.7 0.0 -0.5 0.0 -0.1 -1.3
Miserableness 1.3 2.3 7.8 -2.8 -0.7 -0.1 -1.4 -1.1
Guilty feelings 0.1 0.1 0.3 -0.5 0.3 -0.3 -0.4 0.0
Wears glasses or contact lenses 1.1 1.2 3.3 -1.8 -1.1 -0.2 -0.8 -0.9
Ever taken oral contraceptive pill 0.3 0.4 0.8 -0.4 0.4 -0.7 -0.9 -0.5
Hearing aid user 0.2 0.2 0.8 0.9 -0.1 0.4 -0.1 -0.3
Mother’s age at death 0.5 0.7 1.2 1.0 -0.1 -0.0 1.1 1.1
Financial situation satisfaction 1.6 2.0 4.1 -0.1 -2.0 -1.7 -1.0 -1.4
Tinnitus: Yes, now most or all of the time 0.8 0.9 3.9 -2.0 0.0 0.0 0.1 -0.7
Commuting to job workplace: Public transport 1.2 1.5 3.8 0.4 2.0 -1.2 -0.7 -1.2
Eye problems/disorders: Glaucoma 1.1 1.3 4.7 0.6 2.2 1.1 0.4 0.1
Medication: Blood pressure 0.7 1.3 2.3 1.5 0.3 1.0 1.5 1.1
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.6 1.1 1.2 0.4 -0.4 0.1
Supplements: Fish oil (including cod liver oil) 1.9 2.5 7.0 -0.8 -0.8 -0.9 -1.9 -2.6
High cholesterol (Self-reported) 0.3 0.5 1.1 0.1 0.1 0.7 1.0 1.0
Medication: Bendroflumethiazide 1.8 2.7 3.9 1.9 2.0 1.8 1.2 1.2
Medication: Paracetamol 0.5 0.8 1.6 1.2 1.3 -0.6 -0.1 -0.8
Medication: Lisinopril 0.5 0.6 1.1 -0.7 -0.8 1.1 -0.8 0.1
Medication: Atorvastatin 2.4 2.9 4.1 -1.3 -1.4 -1.9 -1.7 -2.0
Illnesses of father: High blood pressure 0.1 0.1 0.4 0.1 -0.5 -0.6 0.1 -0.0
Alcohol drinker status: Never 0.4 0.5 1.7 -0.3 -0.8 1.3 0.5 0.0
Ever smoked 0.3 0.5 0.8 -0.9 0.8 0.6 -0.6 -0.7
Basal metabolic rate 0.4 2.0 4.8 2.2 1.3 0.1 0.5 1.7
Leg fat percentage (left) 0.3 1.1 3.7 1.9 -0.9 -0.2 -0.2 1.0
Arm fat-free mass (left) 0.3 1.6 3.8 1.9 1.4 0.2 0.2 1.5
Number of operations (self-reported) 0.9 1.4 3.6 -0.8 0.0 1.5 1.9 0.6
Average weekly beer plus cider intake 0.9 1.3 3.4 0.6 -0.2 -1.3 -1.8 -1.0
Irritability 3.1 5.2 10.5 -2.0 -0.1 -1.5 -3.1 -3.2
Risk taking 0.8 1.2 2.7 0.8 -1.6 -0.8 -1.1 -0.8
Ever had prostate specific antigen (PSA) test 0.9 1.1 2.1 1.4 1.3 -0.1 1.3 0.3
Fractured/broken bones in last 5 years 0.9 1.1 2.5 -1.1 -1.6 1.2 0.6 0.3
Age started oral contraceptive pill 0.9 1.1 1.7 1.3 1.0 0.8 1.1 1.0
Diastolic blood pressure, automated reading 0.7 2.2 7.3 2.7 0.9 0.7 -0.3 1.5
Ever depressed for a whole week 0.5 0.6 1.6 -0.2 -0.3 -0.9 -0.5 -1.3
Unable to work because of sickness or disability 0.2 0.2 0.6 0.7 0.6 -0.1 -0.3 -0.3
Commuting to job workplace: Cycle 0.5 0.6 2.2 -0.7 1.5 -0.4 -0.3 -0.3
Myopia 0.7 1.0 3.1 -0.9 1.1 0.0 0.2 1.8
Vascular/heart problems diagnosed by doctor 0.3 0.7 2.1 -0.4 -1.4 -0.7 -0.6 -0.6
Cholesterol lowering medication 0.4 0.6 0.9 0.8 0.0 0.9 0.9 0.9
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 3.7 0.7 0.8 1.9 1.9 1.3
Pain experienced in last month 0.7 1.2 3.3 -1.7 -1.8 0.3 0.2 0.3
Supplements: Calcium 2.5 2.8 3.7 -1.9 1.3 1.8 1.9 1.3
Basal cell carcinoma (self-reported) 0.1 0.2 0.3 -0.5 0.2 0.6 0.4 0.0
Heart attack/myocardial infarction (self-reported) 1.2 1.6 3.6 -0.7 -0.8 -1.9 -1.2 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.4 -0.0 1.2 0.7 0.8 0.6
Heart disease (siblings) 0.8 1.0 2.5 -0.3 0.0 -0.5 -1.6 -1.4
Alcohol drinker status: Previous 0.4 0.5 0.8 0.6 -0.9 0.9 -0.6 -0.4
Pack years of smoking 0.3 0.4 1.7 0.1 0.6 1.3 0.0 0.1
Impedance of whole body 0.2 1.2 2.7 -1.4 0.7 0.5 -0.6 -1.6
Leg fat mass (left) 0.4 1.4 5.4 2.3 -0.2 -0.3 -0.1 1.2
Arm predicted mass (left) 0.4 2.2 4.2 2.0 1.5 0.7 0.6 1.9