TWAS hub - TTC39A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0540	0.0270	3.6e-04	0.038	0.013	0.018	0.015	0.009	1.9e-05	0.00850	2.7e-03	5.3e-03	2.4e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.0987	0.0351	3.2e-05	0.021	0.035	0.040	0.042	0.042	7.7e-04	0.00002	6.1e-06	3.5e-06	4.0e-06
3	TCGA	Breast Invasive Carcinoma	0.0229	0.0124	4.4e-03	-0.001	0.007	0.006	NA	0.002	6.1e-01	0.00910	2.1e-02	NA	9.7e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Tinnitus: Yes, now most or all of the time	5.5	6.4	11.3	3.4	2.5	-1.1
Lung cancer (father)	4.7	5.5	8.4	2.9	2.7	-1.0
Diabetes (self-reported)	4.1	6.3	9.1	3.0	3.0	0.9
Serious illness, injury or assault to yourself	4.0	4.8	8.7	2.4	2.9	0.0
Schizophrenia vs Biploar Disorder	3.9	5.1	9.3	-3.1	-2.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	3.8	8.0	15.5	-3.9	-2.8	0.8
Diabetes diagnosed by doctor	3.6	5.9	10.6	3.3	2.6	0.5
Bipolar Disorder (2018)	3.5	5.5	9.8	3.1	2.4	0.8
Migraine (self-reported)	3.5	4.4	9.5	-0.1	-1.9	-3.1
Fractured/broken bones in last 5 years	3.5	4.5	10.6	0.6	3.2	1.6
Medication: Ventolin 100micrograms inhaler	3.4	4.4	9.1	-3.0	-1.5	1.3
Ovarian Cancer	3.3	4.3	8.4	2.9	1.4	-1.6
Had major operations	3.3	3.8	5.2	1.5	2.3	2.0
Age at First Birth	3.2	4.6	12.2	-1.1	-3.5	-0.7
Type 2 Diabetes (T2D) (2018)	3.2	6.1	11.8	3.4	2.5	0.3
Mother’s age at death	3.2	4.1	8.3	0.2	-2.9	-2.0
Illness, injury, bereavement, stress in last 2 years	3.1	3.8	5.9	-2.4	0.2	2.3
Smoking status: Current	3.1	4.9	10.2	-2.1	0.5	3.2
Waist Hip Ratio (WHR)	3.0	13.5	30.6	5.5	2.8	-1.4
Current tobacco smoking	3.0	4.8	9.9	-2.1	0.5	3.1
Depression (Nagel 2018)	2.9	4.3	6.6	2.5	2.6	-0.1
HbA1C	2.9	3.2	5.3	1.9	2.3	-0.7
Medication: Atenolol	2.9	3.6	6.0	-1.2	-1.8	-2.5
Pain all over the body in last month	2.9	3.1	3.9	2.0	1.4	-1.9
Illnesses of father: High blood pressure	2.9	3.5	5.9	-2.4	-2.0	0.9
Alcohol drinker status: Never	2.8	3.4	7.0	0.8	1.6	-2.6
Pulse wave peak to peak time	2.7	3.2	5.3	-2.0	-2.3	-0.1
Illnesses of father: None of the above (group 1)	2.7	3.4	7.5	2.7	0.9	-1.4
Pain type(s) experienced in last month: Hip pain	2.6	3.3	7.6	-2.8	-1.4	0.6
Number of operations (self-reported)	2.6	3.9	5.7	1.0	2.4	2.2
Trunk fat-free mass	2.3	13.3	17.9	-4.2	-2.8	3.8
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	4.7	-0.2	-1.8	-2.2
Pulse wave Arterial Stiffness index	2.3	2.7	4.9	1.7	2.2	0.5
Trunk predicted mass	2.3	13.3	18.0	-4.2	-2.8	3.7
Overall health rating	2.3	5.0	10.0	-1.2	1.9	3.2
Triglycerides	2.2	3.6	7.1	1.9	2.7	0.4
Medication: Cholesterol lowering	2.2	3.4	6.3	1.0	2.5	1.7
Wheeze or whistling in the chest in last year	2.2	3.9	6.8	-2.6	-0.2	2.2
Whole body fat-free mass	2.2	12.3	15.8	-4.0	-2.6	3.8
Impedance of whole body	2.2	11.3	27.7	2.5	0.0	-5.3
Breast Cancer	2.1	5.0	14.5	-0.5	-3.8	-0.4
Medication: Metformin	2.1	2.9	6.2	2.5	1.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.5	1.4	2.1	0.7
Whole body water mass	2.1	12.2	15.7	-4.0	-2.5	3.8
Intelligence (Savage-Jansen 2018)	2.0	6.2	9.7	0.8	2.9	3.1
Severe depression (siblings)	2.0	2.2	5.4	2.3	0.8	-0.8
Impedance of leg (left)	2.0	9.5	22.2	2.5	-0.3	-4.7
Depression (self-reported)	2.0	2.4	5.5	-0.5	1.2	2.3
Emphysema/chronic bronchitis	2.0	2.3	4.4	-2.1	-1.4	-0.7
Medication: Paracetamol	2.0	3.1	7.0	2.6	1.5	-0.4
Arm fat-free mass (left)	2.0	10.2	12.7	-3.6	-2.7	3.2
Fasting Glucose	1.9	2.3	6.0	2.4	0.1	-1.0
Impedance of leg (right)	1.9	9.3	23.8	1.9	-0.6	-4.9
Number of full brothers	1.9	2.4	4.1	-2.0	-1.8	0.3
Heart disease (mother)	1.9	2.3	3.4	1.8	1.8	-0.7
Verbal and Numeric Reasoning (VNR)	1.8	4.3	7.3	0.7	2.7	2.2
Blood Red Count	1.8	16.9	29.1	4.3	1.8	-5.4
Leg predicted mass (left)	1.8	9.3	12.0	-3.4	-2.1	3.5
Arm fat-free mass (right)	1.8	9.0	11.0	-3.3	-2.3	3.3
Basal metabolic rate	1.8	10.1	13.0	-3.6	-2.6	3.2
Basal cell carcinoma (self-reported)	1.8	2.2	6.4	0.3	2.5	0.2
Arm predicted mass (left)	1.8	8.9	11.5	-3.4	-2.6	2.9
Heel T-Score	1.7	13.6	23.4	4.8	4.1	-0.4
Diabetes (mother)	1.7	2.2	3.8	1.9	1.3	-1.0
Leg fat-free mass (left)	1.7	9.1	12.0	-3.3	-2.0	3.5
Maternal smoking around birth	1.7	2.5	6.1	-1.1	0.4	2.5
Age at first live birth	1.7	3.0	6.9	-1.3	-2.6	-0.7
Family relationship satisfaction	1.7	2.1	3.0	-1.6	-1.7	-0.9
Leg fat-free mass (right)	1.7	8.9	13.8	-3.1	-1.8	3.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.3	1.0	1.3	1.8
Ever smoked	1.7	3.0	6.8	-1.1	1.0	2.6
Supplements: Zinc	1.6	1.7	4.7	0.3	-0.6	-2.2
Impedance of arm (left)	1.6	7.5	19.4	1.7	0.0	-4.4
Arm predicted mass (right)	1.6	8.2	10.4	-3.2	-2.1	3.1
Leg predicted mass (right)	1.6	8.7	13.2	-3.1	-1.9	3.6
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.5	1.4	0.6	-1.9
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.4	-0.1	-1.6	-1.8
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.9	0.5	-1.5	-2.2
Medication: Blood pressure	1.5	2.7	5.3	-1.6	0.6	2.3
Bipolar Disorder or Schizophrenia	1.4	3.4	6.3	2.5	1.9	-0.7
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.8	0.6	2.2	0.3
Diabetes (father)	1.4	1.7	3.8	1.9	1.1	0.4
Major Depression (MDD)	1.3	1.5	2.4	0.8	1.5	1.3
Bipolar Disorder (2011)	1.3	1.3	2.7	1.6	1.1	0.0
Mean Putamen Volume	1.3	1.5	2.0	1.4	0.9	-1.3
Height	1.3	24.2	38.7	-6.2	-5.5	2.0
Bilateral oophorectomy (both ovaries removed)	1.3	1.6	2.4	1.5	1.5	0.3
Past tobacco smoking	1.3	2.3	3.9	0.6	-2.0	-1.7
Hearing difficulty/problems with background noise	1.3	2.1	3.9	1.3	0.9	-2.0
Medication: Simvastatin	1.3	1.9	3.3	1.6	1.8	-0.1
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	4.3	2.1	1.7	-0.7
Knee pain experienced in last month	1.3	2.0	5.3	0.4	2.3	0.8
Diastolic blood pressure, automated reading	1.3	4.1	8.4	-2.9	-2.0	-0.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.3	1.1	1.5	-0.9
Hip circumference	1.2	5.2	7.8	-2.8	-2.7	0.9
Hair/balding pattern: Pattern 3	1.2	1.8	4.7	-0.7	-2.2	-0.3
Happiness	1.2	1.4	2.4	-1.3	-1.5	-0.4
Illnesses of mother	1.2	1.4	2.6	-1.6	-0.9	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.4	0.2	1.8	1.5
Pulse rate, automated reading	1.2	3.9	6.5	2.3	2.5	-0.2
Illnesses of siblings: Diabetes	1.2	1.5	3.1	1.1	1.8	0.3
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	4.2	1.0	2.0	0.8
Supplements: Calcium	1.2	1.3	2.7	1.1	1.6	0.0
Ulcerative Colitis (UC)	1.1	2.0	6.0	0.1	-0.3	-2.5
Ever had hysterectomy (womb removed)	1.1	1.3	2.6	0.3	1.0	1.6
Stomach or abdominal pain in last month	1.1	1.4	3.1	1.0	1.8	0.5
Pulse rate	1.1	1.8	3.8	0.3	1.9	1.2
Mouth/teeth dental problems: Dentures	1.1	1.8	3.0	1.3	1.7	-0.8
Medication for cholesterol	1.1	1.7	4.2	-0.2	0.9	2.0
Risk taking	1.1	1.7	2.9	1.3	1.7	0.7
Body Mass Index (BMI) (2010)	1.0	1.4	2.1	-1.4	-0.8	1.2
Smoking Status	1.0	2.3	4.8	-0.7	1.3	2.2
Taking other prescription medications	1.0	1.6	4.2	0.1	2.0	0.8
Impedance of arm (right)	1.0	4.9	13.2	1.1	-0.4	-3.6
Standing height	1.0	10.2	16.9	-4.1	-3.7	0.5
Length of working week for main job	1.0	1.1	2.2	-0.9	-0.6	1.5
Loud music exposure frequency	1.0	1.1	3.0	0.6	1.7	-0.1
Gout (self-reported)	1.0	1.4	2.7	0.7	1.6	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.8	-0.4	-0.6	-1.7
Suffer from ‘nerves’	1.0	1.5	3.1	-1.8	-1.1	0.4
Breast cancer (self-reported)	1.0	1.2	1.5	-0.9	1.2	1.2
Cholesterol lowering medication	1.0	1.5	2.5	1.4	-0.4	-1.6
Pain experienced in last month	1.0	1.6	2.8	1.4	-0.5	1.7
Depressed Affect (Nagel 2018)	0.9	1.9	2.7	1.4	1.6	1.0
Rheumatoid Arthritis	0.9	1.2	3.0	0.6	0.4	1.7
Fed-up feelings	0.9	1.6	3.3	-1.8	-0.9	0.7
Relative age voice broke	0.9	1.4	2.2	1.3	0.6	-1.5
Had menopause	0.9	1.2	2.0	0.8	1.4	-1.0
Number of live births	0.9	1.2	2.4	1.1	1.5	0.0
Exposure to tobacco smoke at home	0.9	1.0	2.2	-0.8	1.5	0.5
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	2.4	1.5	0.4	1.4
Worry too long after embarrassment	0.9	1.5	3.5	-0.0	-1.0	-1.9
Long-standing illness, disability or infirmity	0.9	1.4	2.3	-1.1	0.8	1.5
Medication: Gliclazide	0.9	1.0	2.2	1.5	-0.6	-0.7
Medication: Blood pressure	0.9	1.7	3.2	-0.6	-1.3	-1.8
Ever depressed for a whole week	0.9	1.1	2.3	1.0	1.5	-0.2
Irritable Bowel Disease (IBD)	0.8	1.8	4.9	-0.8	-0.2	-2.2
Reaction Time	0.8	1.6	3.3	1.1	0.5	-1.8
Respiratory disease	0.8	1.9	2.9	-1.7	-0.8	1.4
Vitamin and mineral supplements	0.8	1.1	2.9	-1.7	-0.5	0.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.2	-1.5	0.2	0.9
Weight	0.8	4.1	5.1	-2.3	-2.1	1.7
Qualifications: A levels/AS levels or equivalent	0.8	1.9	3.3	-0.9	-1.2	1.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.0	0.8	1.4	0.6
Headache pain in last month	0.8	1.4	1.7	-1.1	-1.2	-1.3
Birth weight	0.8	1.8	3.8	-1.1	-1.9	-0.6
Angina (self-reported)	0.8	1.1	1.6	-0.6	-1.1	-1.3
Age started oral contraceptive pill	0.8	1.1	2.3	-0.8	-1.5	-0.6
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.7	-0.4	1.1	1.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	1.3	0.4	-0.6
Allergy or Eczema	0.7	1.9	2.9	1.7	1.6	-0.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.3	-0.3	0.9	1.1
Townsend deprivation index at recruitment	0.7	1.0	2.7	-1.6	0.5	0.5
Mouth/teeth dental problems	0.7	1.0	3.0	-0.1	-1.7	0.1
Heart attack	0.7	0.9	1.6	-0.8	0.7	1.3
Fluid intelligence score	0.7	1.4	2.3	0.2	1.5	1.3
Medication: Lansoprazole	0.7	0.7	0.9	0.7	0.9	0.9
Peak expiratory flow (PEF)	0.7	1.6	3.7	0.9	0.4	-1.9
Medication: Paracetamol	0.7	1.2	2.4	1.5	1.1	0.3
Glaucoma (self-reported)	0.7	0.8	1.9	0.2	-0.7	-1.4
Exposure to tobacco smoke outside home	0.7	0.9	2.0	-1.4	-0.5	0.6
Shortness of breath walking on level ground	0.7	0.9	1.4	0.6	1.0	1.2
Medication: Allopurinol	0.7	0.9	1.5	-0.0	1.1	1.2
Leg pain on walking	0.7	0.8	2.2	-0.5	0.3	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.7	-1.3	-0.6	0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.3	0.8	-0.7	-1.1
Osteoporosis (self-reported)	0.7	0.9	1.5	-1.2	1.0	0.5
Commuting to job workplace: Cycle	0.7	0.9	2.0	-1.4	-0.7	0.4
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	0.7	0.5	1.2
Hypothyroidism (self reported)	0.6	1.3	2.8	1.7	0.9	-0.6
Average weekly spirits intake	0.6	0.8	2.0	0.5	-0.3	1.4
Sensitivity / hurt feelings	0.6	0.9	2.0	-0.1	-1.4	-0.9
Angina	0.6	0.8	1.1	-0.8	-0.9	-1.0
Qualifications: CSEs or equivalent	0.6	0.8	2.2	-0.2	-0.5	-1.5
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	-1.4	0.3	0.1
Number of incorrect matches in round	0.6	1.0	1.5	0.6	-1.1	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.0	1.7	0.9	0.2
Father’s age at death	0.6	0.8	2.3	-0.1	-1.5	-0.4
Prospective memory result	0.6	0.7	1.1	0.6	1.0	-0.8
Mean time to correctly identify matches	0.6	1.2	2.1	1.2	0.0	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	0.8	0.9	0.8	-0.8
Comparative height size at age 10	0.6	3.1	4.7	-2.2	-2.0	0.6
Qualifications: nursing, teaching	0.6	0.9	2.2	1.5	0.1	-0.6
Wears glasses or contact lenses	0.6	0.7	1.3	-0.2	0.9	1.1
Hearing aid user	0.6	0.7	1.1	-1.0	0.1	1.0
Pack years of smoking	0.6	1.0	1.4	0.7	1.0	-1.2
Neuroticism (Nagel 2018)	0.5	1.1	2.0	1.4	1.1	0.1
Schizophrenia (2018)	0.5	1.0	2.5	0.6	0.5	-1.6
BMI	0.5	2.7	5.0	-1.3	-1.2	2.2
Lung FVC	0.5	2.7	5.4	2.3	1.5	-0.7
Neuroticism	0.5	1.2	1.9	1.4	0.7	-1.1
Chronotype (morning person)	0.5	1.1	2.2	1.5	0.1	-1.0
Hearing difficulty/problems: Yes	0.5	0.7	1.8	0.1	1.3	0.6
Medication: Co-codamol	0.5	0.5	0.7	-0.8	-0.8	0.5
Average weekly fortified wine intake	0.5	0.5	1.3	-0.4	0.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	0.9	1.2	-0.2
Medication: Levothyroxine sodium	0.5	0.9	1.5	1.2	0.6	-0.8
Medication: Ramipril	0.5	0.6	0.9	0.1	1.0	0.9
Blood clot in the leg (DVT)	0.5	0.7	1.1	1.0	-0.0	-1.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	-0.4	-0.9	-1.0
High blood pressure (siblings)	0.5	0.8	1.6	-0.7	-0.4	1.3
Leg fat percentage (right)	0.5	1.8	3.2	0.6	-1.4	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	0.4	1.3	0.4
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	-1.3	-1.0	0.1
Medication: Omeprazole	0.5	0.6	1.2	0.5	1.1	0.7
Medication: Seretide 50 evohaler	0.5	0.6	1.1	-0.7	-0.6	1.0
Alcohol intake frequency.	0.5	1.2	3.6	0.2	0.2	-1.9
Smoking status: Previous	0.5	0.8	2.4	0.1	1.6	0.1
Average weekly red wine intake	0.5	0.8	2.0	0.4	1.4	0.4
Mood swings	0.5	0.9	1.7	0.5	1.3	0.7
Ever taken oral contraceptive pill	0.5	0.6	1.0	1.0	0.6	0.6
Financial situation satisfaction	0.5	0.7	1.6	0.7	1.3	-0.1
Medication: Bendroflumethiazide	0.5	0.8	1.5	-1.2	-0.7	-0.5
Alzheimer’s Disease (in father)	0.4	0.4	0.9	-0.5	-0.4	-1.0
Crohns Disease (2017)	0.4	0.9	1.5	-1.2	-0.1	-1.1
Coronary Artery Disease (CAD)	0.4	0.5	0.9	-0.5	-0.6	0.9
HDL Cholesterol	0.4	0.7	0.9	-0.5	-0.9	-1.0
LDL Cholesterol	0.4	0.6	1.5	0.3	1.2	0.4
Neuroticism (2016)	0.4	0.6	1.8	-0.4	-0.1	-1.3
Ulcerative Colitis	0.4	0.5	1.4	0.2	0.3	-1.2
Blood White Count	0.4	3.2	6.9	-2.6	-0.6	1.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	0.7	1.1	-0.2
Medication for hormone replacement therapy	0.4	0.5	1.1	0.4	-0.3	-1.1
Pack years adult smoking proportion	0.4	0.6	1.4	0.5	1.2	-0.3
Financial difficulties in last 2 years	0.4	0.5	1.0	-0.1	1.0	0.8
Illnesses of siblings	0.4	0.6	1.4	-0.2	-0.6	-1.2
Worrier / anxious feelings	0.4	0.8	1.4	0.0	-1.0	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.9	-0.1	1.4	0.3
Asthma	0.4	0.9	1.8	-0.8	0.1	1.4
Arm fat mass (right)	0.4	1.7	2.6	-1.3	-1.6	1.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	0.7	0.9	0.5
Comparative body size at age 10	0.4	1.2	1.7	-0.5	-1.3	1.3
Qualifications: College or University degree	0.4	1.2	3.1	-0.1	-0.7	1.8
Medication: Ibuprofen	0.4	0.5	1.1	1.1	0.6	-0.0
Supplements: Vitamin C	0.4	0.5	0.9	-0.0	-0.7	-0.9
Osteoarthritis (self-reported)	0.4	0.5	1.4	-0.1	0.1	1.2
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.4	-0.5	-1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.4	-0.8	-0.8
Medication: Atorvastatin	0.4	0.5	1.4	-0.3	0.0	1.2
Leg fat percentage (left)	0.4	1.6	2.4	0.9	-1.2	-1.5
Myopia	0.4	0.5	0.9	-0.6	-0.9	0.6
Crohns Disease (2012)	0.3	0.5	1.1	-0.7	-0.1	-1.0
Primary Biliary Cirrhosis	0.3	0.4	1.3	-1.1	0.1	-0.1
Cardiovascular Disease	0.3	1.0	1.9	-1.4	-1.0	0.3
Trunk fat percentage	0.3	1.2	2.5	0.6	-0.9	-1.6
Age when periods started (menarche)	0.3	0.7	1.0	1.0	0.7	-0.8
High blood pressure	0.3	0.9	2.3	-1.5	-0.2	0.5
Multivitamins +/- minerals	0.3	0.4	0.9	0.9	0.3	0.4
Body mass index (BMI)	0.3	1.2	2.7	-0.7	-0.7	1.6
Nervous feelings	0.3	0.6	0.9	-0.9	0.0	-1.0
Qualifications: None of the above	0.3	0.7	1.5	-1.2	0.6	-0.6
Time employed in main current job	0.3	0.4	1.0	-0.3	-1.0	-0.1
Pulse wave reflection index	0.3	0.4	0.6	0.2	0.8	-0.7
Medication: Amlodipine	0.3	0.4	1.3	0.2	0.1	-1.1
Body fat percentage	0.3	1.1	2.0	0.7	-0.9	-1.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.5	-0.7	0.7	-0.3
Number of full sisters	0.3	0.4	0.7	0.4	0.9	-0.5
Hypertension (Self-reported)	0.3	0.8	2.2	-1.5	0.0	0.3
Illnesses of father: Heart disease	0.3	0.4	1.0	-1.0	0.1	0.4
Arm fat mass (left)	0.3	1.1	1.3	-0.9	-1.1	1.0
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	-0.9	0.8	-0.1
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.3	0.3	-0.8
Irritability	0.3	0.5	1.3	0.3	0.3	1.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	-0.0	-0.4	-0.9
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.5	1.6	0.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	0.1	1.0	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	0.7	0.0	-0.7
Prostate Cancer	0.2	0.3	0.4	0.7	0.7	0.2
Schizophrenia (2014)	0.2	0.4	1.0	0.2	0.5	-1.0
Blood Eosinophil Count	0.2	1.3	2.6	-1.2	-1.6	0.3
Lung FEV1/FVC ratio	0.2	0.9	2.5	-0.6	1.6	0.0
Hand grip strength (left)	0.2	0.6	1.5	-0.1	-1.2	-0.5
Number of treatments/medications taken	0.2	0.4	1.0	0.5	1.0	0.1
Relative age of first facial hair	0.2	0.4	0.7	0.8	0.0	-0.8
Systolic blood pressure, automated reading	0.2	0.6	1.4	0.6	0.3	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	1.0	0.5	-0.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.2	-0.4	-0.6
High blood pressure (mother)	0.2	0.3	0.9	0.1	-0.9	0.0
Trunk fat mass	0.2	0.7	1.9	-0.5	-1.4	-0.2
Waist circumference	0.2	0.6	1.2	-0.3	-0.6	1.1
Alcohol usually taken with meals	0.2	0.3	0.5	0.7	-0.4	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.3	0.8	0.3
Forced vital capacity (FVC)	0.2	0.7	1.3	-0.8	-1.1	-0.3
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.4	-0.3	0.9
Falls in the last year	0.2	0.3	0.5	-0.6	-0.1	0.7
Tense / ‘highly strung’	0.2	0.3	0.5	-0.7	0.3	-0.6
Birth weight of first child	0.2	0.4	1.0	-0.3	-1.0	0.0
Forced vital capacity (FVC), Best measure	0.2	0.7	1.2	-0.7	-1.1	0.6
Number of children fathered	0.2	0.2	0.4	0.2	0.3	0.6
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.4	-0.1	0.7
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.0	0.3	-0.9
Leg fat mass (right)	0.2	0.6	1.3	-0.6	-1.1	0.5
Chest pain or discomfort	0.2	0.3	0.8	-0.9	0.1	-0.2
Loneliness, isolation	0.2	0.3	0.5	0.7	0.4	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.6	-0.1	-0.5
Mineral and other dietary supplements	0.2	0.2	0.5	-0.4	0.7	0.2
Asthma (self-reported)	0.2	0.4	0.9	-0.4	0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	0.1	0.7	1.0
High cholesterol (Self-reported)	0.2	0.4	0.5	0.7	0.5	-0.5
Worry (Nagel 2018)	0.1	0.2	0.4	0.1	0.4	-0.6
Lupus	0.1	0.2	0.5	-0.7	0.1	0.3
Blood Platelet Count	0.1	1.6	2.3	-0.4	1.5	1.5
Systolic Blood Pressure	0.1	0.7	1.5	-0.6	-0.6	-1.2
Hair Pigment	0.1	1.8	4.9	-0.6	-2.2	0.2
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	0.5	0.3	-0.1
Sitting height	0.1	1.0	1.4	-1.1	0.5	1.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.5	0.3	-0.1
Had other major operations	0.1	0.1	0.2	-0.5	0.0	-0.1
Allergy	0.1	0.2	0.3	0.5	-0.1	-0.4
Neuroticism score	0.1	0.2	0.6	0.1	-0.2	-0.8
Arm fat percentage (right)	0.1	0.3	0.7	-0.3	-0.8	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.6	-0.6	-0.8	-0.7
Noisy workplace	0.1	0.1	0.2	0.2	0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	-0.5	-0.5	0.4
Breastfed as a baby	0.1	0.1	0.3	0.0	-0.5	-0.1
Hair/balding pattern: Pattern 4	0.1	0.1	0.2	0.2	-0.5	0.3
Health satisfaction	0.1	0.2	0.2	-0.5	0.3	0.5
Whole body fat mass	0.1	0.5	1.2	-0.4	-1.1	0.3
Age at last live birth	0.1	0.1	0.2	-0.2	-0.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.5	-0.0	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.1	0.4	0.2
Ever had bowel cancer screening	0.1	0.1	0.2	-0.3	0.4	0.2
Friendships satisfaction	0.1	0.1	0.3	-0.2	-0.5	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.3	-0.5	-0.3
Back pain experienced in last month	0.1	0.2	0.4	-0.2	0.7	-0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.2	0.3	0.3
Miserableness	0.1	0.2	0.4	-0.7	-0.2	0.5
Guilty feelings	0.1	0.1	0.2	-0.3	-0.3	0.5
Medication: Lisinopril	0.1	0.1	0.2	-0.1	-0.1	0.5
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.3	-0.3	0.4
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.0	0.7	0.2
Leg fat mass (left)	0.1	0.6	1.1	-0.4	-1.0	0.6
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	0.3	-0.2	0.3
Tanning	0.0	0.4	0.6	-0.8	0.4	0.7
Hand grip strength (right)	0.0	0.1	0.2	-0.1	-0.3	-0.4
Supplements: Glucosamine	0.0	0.1	0.1	0.2	-0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.1	-0.3	-0.1
Medication: Aspirin	0.0	0.0	0.0	-0.1	0.1	-0.1
Arm fat percentage (left)	0.0	0.1	0.2	0.1	-0.5	-0.1
Medication: Aspirin	0.0	0.1	0.2	0.1	0.1	-0.4
Heart disease (siblings)	0.0	0.1	0.1	-0.2	0.2	-0.2
Alcohol drinker status: Previous	0.0	0.0	0.1	0.1	0.2	-0.3

Hub : Genes

TTC39A

Models

Trait associations