Hub : Genes

TTC39A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0540	0.0270	3.6e-04	0.038	0.013	0.018	0.015	0.009	1.9e-05	0.00850	2.7e-03	5.3e-03	2.4e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.0987	0.0351	3.2e-05	0.021	0.035	0.040	0.042	0.042	7.7e-04	0.00002	6.1e-06	3.5e-06	4.0e-06
3	TCGA	Breast Invasive Carcinoma	0.0229	0.0124	4.4e-03	-0.001	0.007	0.006	NA	0.002	6.1e-01	0.00910	2.1e-02	NA	9.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	3.5	5.5	9.8	3.1	2.4	0.8
Bipolar Disorder or Schizophrenia	1.4	3.4	6.3	2.5	1.9	-0.7
Depressed Affect (Nagel 2018)	0.9	1.9	2.7	1.4	1.6	1.0
Depression (Nagel 2018)	2.9	4.3	6.6	2.5	2.6	-0.1
Intelligence (Savage-Jansen 2018)	2.0	6.2	9.7	0.8	2.9	3.1
Neuroticism (Nagel 2018)	0.5	1.1	2.0	1.4	1.1	0.1
Schizophrenia (2018)	0.5	1.0	2.5	0.6	0.5	-1.6
Schizophrenia vs Biploar Disorder	3.9	5.1	9.3	-3.1	-2.4	0.5
Worry (Nagel 2018)	0.1	0.2	0.4	0.1	0.4	-0.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	0.7	0.5	1.2
Alzheimer’s Disease (in father)	0.4	0.4	0.9	-0.5	-0.4	-1.0
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	0.3	-0.2	0.3
Crohns Disease (2017)	0.4	0.9	1.5	-1.2	-0.1	-1.1
Irritable Bowel Disease (IBD)	0.8	1.8	4.9	-0.8	-0.2	-2.2
Ulcerative Colitis (UC)	1.1	2.0	6.0	0.1	-0.3	-2.5
Major Depression (MDD)	1.3	1.5	2.4	0.8	1.5	1.3
Reaction Time	0.8	1.6	3.3	1.1	0.5	-1.8
Verbal and Numeric Reasoning (VNR)	1.8	4.3	7.3	0.7	2.7	2.2
Breast Cancer	2.1	5.0	14.5	-0.5	-3.8	-0.4
Ovarian Cancer	3.3	4.3	8.4	2.9	1.4	-1.6
Prostate Cancer	0.2	0.3	0.4	0.7	0.7	0.2
Age at First Birth	3.2	4.6	12.2	-1.1	-3.5	-0.7
Bipolar Disorder (2011)	1.3	1.3	2.7	1.6	1.1	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	2.1	-1.4	-0.8	1.2
Coronary Artery Disease (CAD)	0.4	0.5	0.9	-0.5	-0.6	0.9
Crohns Disease (2012)	0.3	0.5	1.1	-0.7	-0.1	-1.0
Mean Putamen Volume	1.3	1.5	2.0	1.4	0.9	-1.3
Fasting Glucose	1.9	2.3	6.0	2.4	0.1	-1.0
HbA1C	2.9	3.2	5.3	1.9	2.3	-0.7
HDL Cholesterol	0.4	0.7	0.9	-0.5	-0.9	-1.0
LDL Cholesterol	0.4	0.6	1.5	0.3	1.2	0.4
Lupus	0.1	0.2	0.5	-0.7	0.1	0.3
Neuroticism (2016)	0.4	0.6	1.8	-0.4	-0.1	-1.3
Primary Biliary Cirrhosis	0.3	0.4	1.3	-1.1	0.1	-0.1
Rheumatoid Arthritis	0.9	1.2	3.0	0.6	0.4	1.7
Schizophrenia (2014)	0.2	0.4	1.0	0.2	0.5	-1.0
Triglycerides	2.2	3.6	7.1	1.9	2.7	0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	1.3	0.4	-0.6
Ulcerative Colitis	0.4	0.5	1.4	0.2	0.3	-1.2
Blood Eosinophil Count	0.2	1.3	2.6	-1.2	-1.6	0.3
Blood Platelet Count	0.1	1.6	2.3	-0.4	1.5	1.5
Blood Red Count	1.8	16.9	29.1	4.3	1.8	-5.4
Blood White Count	0.4	3.2	6.9	-2.6	-0.6	1.6
Heel T-Score	1.7	13.6	23.4	4.8	4.1	-0.4
BMI	0.5	2.7	5.0	-1.3	-1.2	2.2
Height	1.3	24.2	38.7	-6.2	-5.5	2.0
Waist Hip Ratio (WHR)	3.0	13.5	30.6	5.5	2.8	-1.4
Systolic Blood Pressure	0.1	0.7	1.5	-0.6	-0.6	-1.2
Smoking Status	1.0	2.3	4.8	-0.7	1.3	2.2
Allergy or Eczema	0.7	1.9	2.9	1.7	1.6	-0.5
Cardiovascular Disease	0.3	1.0	1.9	-1.4	-1.0	0.3
Hypothyroidism (self reported)	0.6	1.3	2.8	1.7	0.9	-0.6
Respiratory disease	0.8	1.9	2.9	-1.7	-0.8	1.4
Type 2 Diabetes (T2D) (2018)	3.2	6.1	11.8	3.4	2.5	0.3
Lung FEV1/FVC ratio	0.2	0.9	2.5	-0.6	1.6	0.0
Lung FVC	0.5	2.7	5.4	2.3	1.5	-0.7
Neuroticism	0.5	1.2	1.9	1.4	0.7	-1.1
Chronotype (morning person)	0.5	1.1	2.2	1.5	0.1	-1.0
Hair Pigment	0.1	1.8	4.9	-0.6	-2.2	0.2
Tanning	0.0	0.4	0.6	-0.8	0.4	0.7
Hand grip strength (left)	0.2	0.6	1.5	-0.1	-1.2	-0.5
Number of treatments/medications taken	0.2	0.4	1.0	0.5	1.0	0.1
Average weekly spirits intake	0.6	0.8	2.0	0.5	-0.3	1.4
Sensitivity / hurt feelings	0.6	0.9	2.0	-0.1	-1.4	-0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	0.7	1.1	-0.2
Hearing difficulty/problems: Yes	0.5	0.7	1.8	0.1	1.3	0.6
Relative age of first facial hair	0.2	0.4	0.7	0.8	0.0	-0.8
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.8	0.6	2.2	0.3
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.5	1.4	0.6	-1.9
Ever had hysterectomy (womb removed)	1.1	1.3	2.6	0.3	1.0	1.6
Systolic blood pressure, automated reading	0.2	0.6	1.4	0.6	0.3	-1.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.3	-0.3	0.9	1.1
Angina	0.6	0.8	1.1	-0.8	-0.9	-1.0
Medication for hormone replacement therapy	0.4	0.5	1.1	0.4	-0.3	-1.1
Vitamin and mineral supplements	0.8	1.1	2.9	-1.7	-0.5	0.2
Supplements: Zinc	1.6	1.7	4.7	0.3	-0.6	-2.2
Medication: Co-codamol	0.5	0.5	0.7	-0.8	-0.8	0.5
Medication: Metformin	2.1	2.9	6.2	2.5	1.4	0.8
Diabetes (father)	1.4	1.7	3.8	1.9	1.1	0.4
Diabetes (mother)	1.7	2.2	3.8	1.9	1.3	-1.0
Severe depression (siblings)	2.0	2.2	5.4	2.3	0.8	-0.8
Pack years adult smoking proportion	0.4	0.6	1.4	0.5	1.2	-0.3
Impedance of leg (right)	1.9	9.3	23.8	1.9	-0.6	-4.9
Leg fat-free mass (left)	1.7	9.1	12.0	-3.3	-2.0	3.5
Trunk fat percentage	0.3	1.2	2.5	0.6	-0.9	-1.6
Hand grip strength (right)	0.0	0.1	0.2	-0.1	-0.3	-0.4
Townsend deprivation index at recruitment	0.7	1.0	2.7	-1.6	0.5	0.5
Current tobacco smoking	3.0	4.8	9.9	-2.1	0.5	3.1
Average weekly fortified wine intake	0.5	0.5	1.3	-0.4	0.4	-1.1
Maternal smoking around birth	1.7	2.5	6.1	-1.1	0.4	2.5
Fed-up feelings	0.9	1.6	3.3	-1.8	-0.9	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	0.9	1.2	-0.2
Relative age voice broke	0.9	1.4	2.2	1.3	0.6	-1.5
Taking other prescription medications	1.0	1.6	4.2	0.1	2.0	0.8
Age when periods started (menarche)	0.3	0.7	1.0	1.0	0.7	-0.8
Bilateral oophorectomy (both ovaries removed)	1.3	1.6	2.4	1.5	1.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	1.0	0.5	-0.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.2	-0.4	-0.6
Qualifications: CSEs or equivalent	0.6	0.8	2.2	-0.2	-0.5	-1.5
Serious illness, injury or assault to yourself	4.0	4.8	8.7	2.4	2.9	0.0
High blood pressure	0.3	0.9	2.3	-1.5	-0.2	0.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	0.5	0.3	-0.1
Multivitamins +/- minerals	0.3	0.4	0.9	0.9	0.3	0.4
Stomach or abdominal pain in last month	1.1	1.4	3.1	1.0	1.8	0.5
Supplements: Glucosamine	0.0	0.1	0.1	0.2	-0.3	0.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.2	-1.5	0.2	0.9
Medication: Atenolol	2.9	3.6	6.0	-1.2	-1.8	-2.5
Medication: Levothyroxine sodium	0.5	0.9	1.5	1.2	0.6	-0.8
Sitting height	0.1	1.0	1.4	-1.1	0.5	1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	-1.4	0.3	0.1
High blood pressure (mother)	0.2	0.3	0.9	0.1	-0.9	0.0
Body mass index (BMI)	0.3	1.2	2.7	-0.7	-0.7	1.6
Impedance of leg (left)	2.0	9.5	22.2	2.5	-0.3	-4.7
Leg predicted mass (left)	1.8	9.3	12.0	-3.4	-2.1	3.5
Trunk fat mass	0.2	0.7	1.9	-0.5	-1.4	-0.2
Waist circumference	0.2	0.6	1.2	-0.3	-0.6	1.1
Number of incorrect matches in round	0.6	1.0	1.5	0.6	-1.1	-1.2
Past tobacco smoking	1.3	2.3	3.9	0.6	-2.0	-1.7
Alcohol usually taken with meals	0.2	0.3	0.5	0.7	-0.4	-0.6
Nervous feelings	0.3	0.6	0.9	-0.9	0.0	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.3	0.8	0.3
Hearing difficulty/problems with background noise	1.3	2.1	3.9	1.3	0.9	-2.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.5	0.3	-0.1
Had menopause	0.9	1.2	2.0	0.8	1.4	-1.0
Had other major operations	0.1	0.1	0.2	-0.5	0.0	-0.1
Forced vital capacity (FVC)	0.2	0.7	1.3	-0.8	-1.1	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.0	1.7	0.9	0.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.3	1.1	1.5	-0.9
Qualifications: None of the above	0.3	0.7	1.5	-1.2	0.6	-0.6
Financial difficulties in last 2 years	0.4	0.5	1.0	-0.1	1.0	0.8
Mouth/teeth dental problems	0.7	1.0	3.0	-0.1	-1.7	0.1
Heart attack	0.7	0.9	1.6	-0.8	0.7	1.3
Allergy	0.1	0.2	0.3	0.5	-0.1	-0.4
Pain all over the body in last month	2.9	3.1	3.9	2.0	1.4	-1.9
Diabetes (self-reported)	4.1	6.3	9.1	3.0	3.0	0.9
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.4	-0.1	-1.6	-1.8
Medication: Ramipril	0.5	0.6	0.9	0.1	1.0	0.9
Medication: Simvastatin	1.3	1.9	3.3	1.6	1.8	-0.1
Fluid intelligence score	0.7	1.4	2.3	0.2	1.5	1.3
Illnesses of siblings	0.4	0.6	1.4	-0.2	-0.6	-1.2
Neuroticism score	0.1	0.2	0.6	0.1	-0.2	-0.8
Weight	0.8	4.1	5.1	-2.3	-2.1	1.7
Impedance of arm (right)	1.0	4.9	13.2	1.1	-0.4	-3.6
Arm fat percentage (right)	0.1	0.3	0.7	-0.3	-0.8	0.1
Trunk fat-free mass	2.3	13.3	17.9	-4.2	-2.8	3.8
Hip circumference	1.2	5.2	7.8	-2.8	-2.7	0.9
Time employed in main current job	0.3	0.4	1.0	-0.3	-1.0	-0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.4	-0.3	0.9
Father’s age at death	0.6	0.8	2.3	-0.1	-1.5	-0.4
Worrier / anxious feelings	0.4	0.8	1.4	0.0	-1.0	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.9	-0.1	1.4	0.3
Falls in the last year	0.2	0.3	0.5	-0.6	-0.1	0.7
Hair/balding pattern: Pattern 3	1.2	1.8	4.7	-0.7	-2.2	-0.3
Number of live births	0.9	1.2	2.4	1.1	1.5	0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.6	-0.6	-0.8	-0.7
Pulse rate	1.1	1.8	3.8	0.3	1.9	1.2
Happiness	1.2	1.4	2.4	-1.3	-1.5	-0.4
Noisy workplace	0.1	0.1	0.2	0.2	0.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.8	1.9	3.3	-0.9	-1.2	1.8
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	4.7	-0.2	-1.8	-2.2
Mouth/teeth dental problems: Dentures	1.1	1.8	3.0	1.3	1.7	-0.8
Asthma	0.4	0.9	1.8	-0.8	0.1	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.1	-0.3	-0.1
Medication: Cholesterol lowering	2.2	3.4	6.3	1.0	2.5	1.7
Depression (self-reported)	2.0	2.4	5.5	-0.5	1.2	2.3
Medication: Lansoprazole	0.7	0.7	0.9	0.7	0.9	0.9
Prospective memory result	0.6	0.7	1.1	0.6	1.0	-0.8
Lung cancer (father)	4.7	5.5	8.4	2.9	2.7	-1.0
Illnesses of mother	1.2	1.4	2.6	-1.6	-0.9	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	-0.5	-0.5	0.4
Pulse wave Arterial Stiffness index	2.3	2.7	4.9	1.7	2.2	0.5
Impedance of arm (left)	1.6	7.5	19.4	1.7	0.0	-4.4
Arm fat mass (right)	0.4	1.7	2.6	-1.3	-1.6	1.0
Trunk predicted mass	2.3	13.3	18.0	-4.2	-2.8	3.7
Standing height	1.0	10.2	16.9	-4.1	-3.7	0.5
Length of working week for main job	1.0	1.1	2.2	-0.9	-0.6	1.5
Exposure to tobacco smoke at home	0.9	1.0	2.2	-0.8	1.5	0.5
Breastfed as a baby	0.1	0.1	0.3	0.0	-0.5	-0.1
Tense / ‘highly strung’	0.2	0.3	0.5	-0.7	0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.4	0.2	1.8	1.5
Hair/balding pattern: Pattern 4	0.1	0.1	0.2	0.2	-0.5	0.3
Birth weight of first child	0.2	0.4	1.0	-0.3	-1.0	0.0
Peak expiratory flow (PEF)	0.7	1.6	3.7	0.9	0.4	-1.9
Pulse wave reflection index	0.3	0.4	0.6	0.2	0.8	-0.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	0.7	0.9	0.5
Loud music exposure frequency	1.0	1.1	3.0	0.6	1.7	-0.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	2.4	1.5	0.4	1.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.0	0.8	1.4	0.6
Blood clot in the leg (DVT)	0.5	0.7	1.1	1.0	-0.0	-1.1
Medication: Paracetamol	0.7	1.2	2.4	1.5	1.1	0.3
Headache pain in last month	0.8	1.4	1.7	-1.1	-1.2	-1.3
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.9	0.5	-1.5	-2.2
Glaucoma (self-reported)	0.7	0.8	1.9	0.2	-0.7	-1.4
Gout (self-reported)	1.0	1.4	2.7	0.7	1.6	1.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	4.3	2.1	1.7	-0.7
Medication: Amlodipine	0.3	0.4	1.3	0.2	0.1	-1.1
Medication: Ventolin 100micrograms inhaler	3.4	4.4	9.1	-3.0	-1.5	1.3
Birth weight	0.8	1.8	3.8	-1.1	-1.9	-0.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	-0.4	-0.9	-1.0
High blood pressure (siblings)	0.5	0.8	1.6	-0.7	-0.4	1.3
Forced vital capacity (FVC), Best measure	0.2	0.7	1.2	-0.7	-1.1	0.6
Body fat percentage	0.3	1.1	2.0	0.7	-0.9	-1.4
Leg fat percentage (right)	0.5	1.8	3.2	0.6	-1.4	-1.8
Arm fat-free mass (right)	1.8	9.0	11.0	-3.3	-2.3	3.3
Exposure to tobacco smoke outside home	0.7	0.9	2.0	-1.4	-0.5	0.6
Comparative body size at age 10	0.4	1.2	1.7	-0.5	-1.3	1.3
Number of full brothers	1.9	2.4	4.1	-2.0	-1.8	0.3
Worry too long after embarrassment	0.9	1.5	3.5	-0.0	-1.0	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	0.4	1.3	0.4
Wheeze or whistling in the chest in last year	2.2	3.9	6.8	-2.6	-0.2	2.2
Number of children fathered	0.2	0.2	0.4	0.2	0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.8	-0.4	-0.6	-1.7
Age at first live birth	1.7	3.0	6.9	-1.3	-2.6	-0.7
Pulse wave peak to peak time	2.7	3.2	5.3	-2.0	-2.3	-0.1
Health satisfaction	0.1	0.2	0.2	-0.5	0.3	0.5
Shortness of breath walking on level ground	0.7	0.9	1.4	0.6	1.0	1.2
Qualifications: College or University degree	0.4	1.2	3.1	-0.1	-0.7	1.8
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.4	-0.1	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.5	-0.7	0.7	-0.3
Emphysema/chronic bronchitis	2.0	2.3	4.4	-2.1	-1.4	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	-1.3	-1.0	0.1
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.0	0.3	-0.9
Medication: Blood pressure	1.5	2.7	5.3	-1.6	0.6	2.3
Angina (self-reported)	0.8	1.1	1.6	-0.6	-1.1	-1.3
Migraine (self-reported)	3.5	4.4	9.5	-0.1	-1.9	-3.1
Medication: Ibuprofen	0.4	0.5	1.1	1.1	0.6	-0.0
Medication: Allopurinol	0.7	0.9	1.5	-0.0	1.1	1.2
Medication: Omeprazole	0.5	0.6	1.2	0.5	1.1	0.7
Medication: Seretide 50 evohaler	0.5	0.6	1.1	-0.7	-0.6	1.0
Mean time to correctly identify matches	0.6	1.2	2.1	1.2	0.0	-1.4
Heart disease (mother)	1.9	2.3	3.4	1.8	1.8	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	0.8	0.9	0.8	-0.8
Whole body fat mass	0.1	0.5	1.2	-0.4	-1.1	0.3
Leg fat mass (right)	0.2	0.6	1.3	-0.6	-1.1	0.5
Arm predicted mass (right)	1.6	8.2	10.4	-3.2	-2.1	3.1
Pulse rate, automated reading	1.2	3.9	6.5	2.3	2.5	-0.2
Alcohol intake frequency.	0.5	1.2	3.6	0.2	0.2	-1.9
Comparative height size at age 10	0.6	3.1	4.7	-2.2	-2.0	0.6
Number of full sisters	0.3	0.4	0.7	0.4	0.9	-0.5
Suffer from ‘nerves’	1.0	1.5	3.1	-1.8	-1.1	0.4
Overall health rating	2.3	5.0	10.0	-1.2	1.9	3.2
Chest pain or discomfort	0.2	0.3	0.8	-0.9	0.1	-0.2
Had major operations	3.3	3.8	5.2	1.5	2.3	2.0
Age at last live birth	0.1	0.1	0.2	-0.2	-0.3	-0.4
Family relationship satisfaction	1.7	2.1	3.0	-1.6	-1.7	-0.9
Leg pain on walking	0.7	0.8	2.2	-0.5	0.3	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.7	-1.3	-0.6	0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.3	0.8	-0.7	-1.1
Illness, injury, bereavement, stress in last 2 years	3.1	3.8	5.9	-2.4	0.2	2.3
Medication: Aspirin	0.0	0.0	0.0	-0.1	0.1	-0.1
Supplements: Vitamin C	0.4	0.5	0.9	-0.0	-0.7	-0.9
Knee pain experienced in last month	1.3	2.0	5.3	0.4	2.3	0.8
Hypertension (Self-reported)	0.3	0.8	2.2	-1.5	0.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.5	-0.0	0.5
Illnesses of father: Heart disease	0.3	0.4	1.0	-1.0	0.1	0.4
Illnesses of siblings: Diabetes	1.2	1.5	3.1	1.1	1.8	0.3
Smoking status: Previous	0.5	0.8	2.4	0.1	1.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted	3.8	8.0	15.5	-3.9	-2.8	0.8
Whole body fat-free mass	2.2	12.3	15.8	-4.0	-2.6	3.8
Leg fat-free mass (right)	1.7	8.9	13.8	-3.1	-1.8	3.7
Arm fat percentage (left)	0.0	0.1	0.2	0.1	-0.5	-0.1
Average weekly red wine intake	0.5	0.8	2.0	0.4	1.4	0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.1	0.4	0.2
Mood swings	0.5	0.9	1.7	0.5	1.3	0.7
Loneliness, isolation	0.2	0.3	0.5	0.7	0.4	-0.4
Long-standing illness, disability or infirmity	0.9	1.4	2.3	-1.1	0.8	1.5
Ever had bowel cancer screening	0.1	0.1	0.2	-0.3	0.4	0.2
Diabetes diagnosed by doctor	3.6	5.9	10.6	3.3	2.6	0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.5	1.4	2.1	0.7
Friendships satisfaction	0.1	0.1	0.3	-0.2	-0.5	-0.2
Qualifications: nursing, teaching	0.6	0.9	2.2	1.5	0.1	-0.6
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.6	-0.1	-0.5
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.3	-0.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	4.2	1.0	2.0	0.8
Medication for cholesterol	1.1	1.7	4.2	-0.2	0.9	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.3	1.0	1.3	1.8
Back pain experienced in last month	0.1	0.2	0.4	-0.2	0.7	-0.3
Mineral and other dietary supplements	0.2	0.2	0.5	-0.4	0.7	0.2
Breast cancer (self-reported)	1.0	1.2	1.5	-0.9	1.2	1.2
Asthma (self-reported)	0.2	0.4	0.9	-0.4	0.1	0.9
Osteoporosis (self-reported)	0.7	0.9	1.5	-1.2	1.0	0.5
Osteoarthritis (self-reported)	0.4	0.5	1.4	-0.1	0.1	1.2
Medication: Aspirin	0.0	0.1	0.2	0.1	0.1	-0.4
Medication: Gliclazide	0.9	1.0	2.2	1.5	-0.6	-0.7
Illnesses of father: None of the above (group 1)	2.7	3.4	7.5	2.7	0.9	-1.4
Smoking status: Current	3.1	4.9	10.2	-2.1	0.5	3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	0.1	0.7	1.0
Whole body water mass	2.1	12.2	15.7	-4.0	-2.5	3.8
Leg predicted mass (right)	1.6	8.7	13.2	-3.1	-1.9	3.6
Arm fat mass (left)	0.3	1.1	1.3	-0.9	-1.1	1.0
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	-0.9	0.8	-0.1
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.2	0.3	0.3
Miserableness	0.1	0.2	0.4	-0.7	-0.2	0.5
Guilty feelings	0.1	0.1	0.2	-0.3	-0.3	0.5
Wears glasses or contact lenses	0.6	0.7	1.3	-0.2	0.9	1.1
Ever taken oral contraceptive pill	0.5	0.6	1.0	1.0	0.6	0.6
Hearing aid user	0.6	0.7	1.1	-1.0	0.1	1.0
Mother’s age at death	3.2	4.1	8.3	0.2	-2.9	-2.0
Financial situation satisfaction	0.5	0.7	1.6	0.7	1.3	-0.1
Tinnitus: Yes, now most or all of the time	5.5	6.4	11.3	3.4	2.5	-1.1
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.3	0.3	-0.8
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.4	-0.5	-1.0
Medication: Blood pressure	0.9	1.7	3.2	-0.6	-1.3	-1.8
Pain type(s) experienced in last month: Hip pain	2.6	3.3	7.6	-2.8	-1.4	0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.4	-0.8	-0.8
High cholesterol (Self-reported)	0.2	0.4	0.5	0.7	0.5	-0.5
Medication: Bendroflumethiazide	0.5	0.8	1.5	-1.2	-0.7	-0.5
Medication: Paracetamol	2.0	3.1	7.0	2.6	1.5	-0.4
Medication: Lisinopril	0.1	0.1	0.2	-0.1	-0.1	0.5
Medication: Atorvastatin	0.4	0.5	1.4	-0.3	0.0	1.2
Illnesses of father: High blood pressure	2.9	3.5	5.9	-2.4	-2.0	0.9
Alcohol drinker status: Never	2.8	3.4	7.0	0.8	1.6	-2.6
Ever smoked	1.7	3.0	6.8	-1.1	1.0	2.6
Basal metabolic rate	1.8	10.1	13.0	-3.6	-2.6	3.2
Leg fat percentage (left)	0.4	1.6	2.4	0.9	-1.2	-1.5
Arm fat-free mass (left)	2.0	10.2	12.7	-3.6	-2.7	3.2
Number of operations (self-reported)	2.6	3.9	5.7	1.0	2.4	2.2
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.3	-0.3	0.4
Irritability	0.3	0.5	1.3	0.3	0.3	1.2
Risk taking	1.1	1.7	2.9	1.3	1.7	0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	-0.0	-0.4	-0.9
Fractured/broken bones in last 5 years	3.5	4.5	10.6	0.6	3.2	1.6
Age started oral contraceptive pill	0.8	1.1	2.3	-0.8	-1.5	-0.6
Diastolic blood pressure, automated reading	1.3	4.1	8.4	-2.9	-2.0	-0.2
Ever depressed for a whole week	0.9	1.1	2.3	1.0	1.5	-0.2
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.0	0.7	0.2
Commuting to job workplace: Cycle	0.7	0.9	2.0	-1.4	-0.7	0.4
Myopia	0.4	0.5	0.9	-0.6	-0.9	0.6
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.5	1.6	0.5	-0.1
Cholesterol lowering medication	1.0	1.5	2.5	1.4	-0.4	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	0.1	1.0	0.3
Pain experienced in last month	1.0	1.6	2.8	1.4	-0.5	1.7
Supplements: Calcium	1.2	1.3	2.7	1.1	1.6	0.0
Basal cell carcinoma (self-reported)	1.8	2.2	6.4	0.3	2.5	0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.7	-0.4	1.1	1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	0.7	0.0	-0.7
Heart disease (siblings)	0.0	0.1	0.1	-0.2	0.2	-0.2
Alcohol drinker status: Previous	0.0	0.0	0.1	0.1	0.2	-0.3
Pack years of smoking	0.6	1.0	1.4	0.7	1.0	-1.2
Impedance of whole body	2.2	11.3	27.7	2.5	0.0	-5.3
Leg fat mass (left)	0.1	0.6	1.1	-0.4	-1.0	0.6
Arm predicted mass (left)	1.8	8.9	11.5	-3.4	-2.6	2.9