Best TWAS P=1.73e-82 · Best GWAS P=2.29e-100 conditioned to 0
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC100507032 | 0.08 | 0.06 | enet | 14 | 0.08 | 4.6e-10 | 7.9 | -7.5 | 9.5e-14 | 0.07 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Artery Aorta | PLXND1 | 0.12 | 0.01 | lasso | 3 | 0.01 | 1.5e-01 | 9.0 | -8.6 | 6.2e-18 | 0.05 | 0.06 | 0.05 | TRUE |
| 3 | GTEx | Artery Tibial | RP11-723O4.9 | 0.12 | 0.04 | lasso | 5 | 0.06 | 3.4e-05 | 1.4 | 12.4 | 2.2e-35 | -0.52 | 0.08 | 0.87 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | RP11-723O4.2 | 0.29 | 0.02 | lasso | 4 | 0.07 | 6.2e-03 | 1.5 | 7.5 | 8.3e-14 | -0.09 | 0.11 | 0.05 | FALSE |
| 5 | GTEx | Brain Cortex | COPG1 | 0.24 | 0.00 | enet | 57 | 0.03 | 5.3e-02 | -18.9 | -12.2 | 5.7e-34 | 0.50 | 0.03 | 0.47 | TRUE |
| 6 | GTEx | Esophagus Muscularis | IFT122 | 0.17 | 0.00 | enet | 21 | 0.02 | 1.9e-02 | 2.7 | -7.9 | 3.5e-15 | 0.13 | 0.08 | 0.04 | TRUE |
| 7 | GTEx | Testis | HMCES | 0.75 | 0.56 | lasso | 8 | 0.55 | 8.4e-29 | 10.8 | 10.8 | 2.0e-27 | -0.15 | 1.00 | 0.00 | TRUE |
| 8 | METSIM | Adipose | COPG1 | 0.04 | 0.02 | bslmm | 303 | 0.03 | 7.6e-06 | 10.5 | -10.8 | 5.9e-27 | 0.33 | 0.78 | 0.02 | TRUE |
| 9 | YFS | Blood | H1FX | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.4e-03 | -18.9 | 19.1 | 3.0e-81 | -0.84 | 0.11 | 0.41 | TRUE |
| 10 | YFS | Blood | RPN1 | 0.11 | 0.02 | enet | 34 | 0.04 | 1.8e-13 | -1.6 | 6.2 | 4.0e-10 | -0.18 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | H1FX | 0.02 | 0.02 | lasso | 5 | 0.03 | 6.5e-07 | 11.1 | 19.2 | 1.7e-82 | -0.62 | 0.10 | 0.87 | TRUE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAB43 | 0.02 | 0.02 | blup | 35 | 0.02 | 7.8e-05 | 4.5 | 6.0 | 2.3e-09 | -0.05 | 0.03 | 0.94 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PLXND1 | 0.06 | 0.01 | enet | 9 | 0.03 | 1.4e-04 | 3.9 | 5.9 | 3.2e-09 | 0.00 | 0.00 | 0.94 | TRUE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | H1FX | 0.02 | 0.00 | blup | 36 | 0.00 | 5.1e-01 | -21.3 | 19.1 | 5.4e-81 | -0.65 | 0.00 | 0.69 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PLXND1 | 0.08 | 0.06 | blup | 55 | 0.08 | 1.8e-09 | 5.1 | 6.1 | 1.0e-09 | -0.05 | 0.85 | 0.15 | FALSE |