Best TWAS P=1.44e-10 · Best GWAS P=7.2e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AP2B1 | 0.08 | 0.10 | bslmm | 445 | 0.08 | 3.4e-10 | 5.7 | 6.4 | 1.4e-10 | 0.98 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RASL10B | 0.10 | 0.04 | enet | 10 | 0.04 | 1.8e-04 | 5.7 | 5.6 | 2.3e-08 | 0.92 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RASL10B | 0.11 | 0.05 | lasso | 3 | 0.02 | 2.7e-02 | 5.6 | 5.5 | 3.0e-08 | 0.99 | 0.02 | 0.95 | FALSE |
| 4 | GTEx | Brain Caudate basal ganglia | PEX12 | 0.38 | 0.02 | lasso | 9 | 0.05 | 1.4e-02 | 5.7 | 5.5 | 3.0e-08 | 0.76 | 0.02 | 0.72 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | CCL4 | 0.07 | -0.01 | lasso | 3 | 0.08 | 3.9e-05 | 3.1 | 5.4 | 8.2e-08 | 0.60 | 0.04 | 0.73 | FALSE |
| 6 | GTEx | Testis | AP2B1 | 0.29 | 0.13 | lasso | 5 | 0.15 | 4.6e-07 | 5.5 | 5.5 | 3.4e-08 | 0.98 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AP2B1 | 0.02 | 0.02 | lasso | 1 | 0.02 | 4.8e-03 | 5.7 | 5.7 | 1.4e-08 | 1.00 | 0.01 | 0.92 | FALSE |