TWAS hub - PEX12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0550	0.0240	3.0e-03	0.003	0.008	-0.002	0.008	0.001	0.120	0.0320	0.68000	0.028	0.2400
2	GTEx	Adipose Subcutaneous	0.0980	0.0330	1.4e-05	0.003	NA	0.017	NA	0.001	0.190	NA	0.01300	NA	0.2700
3	GTEx	Artery Tibial	0.0463	0.0199	5.9e-03	0.014	NA	0.038	NA	0.029	0.026	NA	0.00053	NA	0.0024
4	GTEx	Brain Caudate basal ganglia	0.3750	0.1130	1.4e-03	0.017	NA	0.017	NA	0.051	0.110	NA	0.11000	NA	0.0140
5	TCGA	Colon Adenocarcinoma	0.1320	0.0720	4.3e-03	0.024	0.018	0.012	NA	0.017	0.015	0.0290	0.06400	NA	0.0340
6	TCGA	Testicular Germ Cell Tumors	0.3230	0.1350	8.7e-03	0.016	0.056	0.030	NA	0.055	0.090	0.0049	0.03200	NA	0.0052

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Platelet Count	13.6	157.5	368.6	-14.3	4.9	3.4	-19.2	-15.8	-9.3
Chronotype (morning person)	5.4	12.4	30.7	3.4	2.9	3.7	5.5	3.2	0.0
Father’s age at death	4.6	6.2	13.0	-2.0	3.6	2.9	1.8	-0.3	-2.9
Alcohol usually taken with meals	3.9	6.2	13.8	-2.5	3.1	3.7	1.9	-1.9	-0.7
Medication: Atenolol	3.8	4.7	12.4	-0.2	-3.5	-2.1	-2.9	-1.1	-1.3
Miserableness	3.3	5.7	11.0	2.2	-2.9	-3.3	-1.7	2.2	1.4
Medication: Ventolin 100micrograms inhaler	3.2	4.1	11.4	2.4	-1.9	-0.6	-0.3	3.4	1.8
Age at First Birth	3.1	4.5	9.5	0.2	2.9	2.9	3.1	-0.0	0.8
Age started oral contraceptive pill	3.1	3.9	11.1	0.3	1.6	2.5	3.3	1.2	-1.4
Overall health rating	2.8	5.9	13.4	1.6	-3.6	-3.7	-2.5	0.7	0.6
Qualifications: None of the above	2.7	5.7	12.1	-0.8	-2.6	-2.9	-3.5	-1.5	-2.0
Depression (self-reported)	2.4	2.9	6.5	1.4	-2.1	-2.5	-1.7	1.2	0.5
Depression (Nagel 2018)	2.3	3.4	11.2	0.7	-1.8	-3.4	-2.1	0.6	-0.6
Frequency of depressed mood in last 2 weeks	2.3	3.3	10.8	1.6	-1.7	-3.3	-0.8	1.6	-0.0
Serious illness, injury or assault to yourself	2.3	2.8	6.4	2.0	-2.5	-2.0	0.2	0.9	1.1
Health satisfaction	2.3	3.0	6.2	1.6	-1.9	-1.7	-0.6	2.5	1.6
Medication: Aspirin	2.3	3.0	12.0	-0.1	-1.9	-0.8	-0.2	-1.2	-3.5
Townsend deprivation index at recruitment	2.2	3.1	6.1	1.5	-1.7	-1.8	-1.6	2.5	1.2
Asthma	2.2	4.3	6.8	2.4	-0.1	1.1	2.5	2.4	2.6
Number of children fathered	2.2	2.5	7.3	-1.4	0.2	-0.5	-0.1	-2.7	-2.3
Supplements: Calcium	2.2	2.5	6.3	2.5	-0.9	-0.9	1.6	0.8	1.9
Lung cancer (father)	2.1	2.4	6.5	1.2	-2.5	-1.9	-0.9	1.2	0.9
Exposure to tobacco smoke at home	2.1	2.3	5.5	-2.1	-1.8	-0.9	-2.3	-0.6	-0.1
Suffer from ‘nerves’	2.1	3.4	7.0	1.4	-2.3	-2.6	-1.9	1.5	-0.2
Asthma (self-reported)	2.1	4.1	7.7	2.1	-0.1	1.2	2.6	2.1	2.8
Depressed Affect (Nagel 2018)	2.0	4.1	9.1	1.6	-3.0	-3.0	-1.3	1.4	0.1
Fed-up feelings	2.0	3.6	8.4	1.2	-2.6	-2.9	-1.9	1.1	0.3
Happiness	2.0	2.5	7.7	2.0	-0.8	-2.8	-0.3	1.4	-0.6
Myopia	2.0	3.0	8.4	0.4	1.2	2.6	2.9	-0.1	1.0
Medication: Omeprazole	1.9	2.3	6.2	0.3	-1.3	-2.5	-2.2	0.3	0.9
Heart attack/myocardial infarction (self-reported)	1.9	2.5	6.8	-0.6	-2.2	-0.8	-0.9	-1.2	-2.6
Major Depression (MDD)	1.8	2.2	8.2	-1.8	-0.6	-0.3	-2.9	-1.0	-0.4
Neuroticism (2016)	1.8	2.6	6.7	1.3	-2.0	-2.6	-1.4	0.2	-1.2
Medication: Co-codamol	1.8	2.1	3.6	1.9	-1.6	-1.6	-0.6	1.9	0.5
Taking other prescription medications	1.8	2.8	5.0	1.9	-1.7	-2.2	-1.0	2.2	0.3
Chronic bronchitis/emphysema (mother)	1.8	2.1	8.7	0.4	-1.4	-2.9	-0.9	0.7	0.3
Medication: Aspirin	1.8	2.3	9.4	-0.6	-1.6	-0.3	-0.4	-1.3	-3.1
Handedness (chirality/laterality): Left-handed	1.8	2.2	4.7	-1.1	-1.0	-1.3	-2.2	-0.6	-2.1
Ever used hormone-replacement therapy (HRT)	1.7	2.2	10.0	-0.9	-0.1	1.0	0.4	-1.1	-3.2
Impedance of leg (right)	1.7	8.1	23.0	-4.8	1.7	0.4	-1.8	-3.6	-2.6
Impedance of leg (left)	1.7	8.1	20.8	-4.6	2.0	0.3	-1.8	-3.5	-2.9
Heart attack	1.7	2.1	5.3	-0.3	-2.1	-0.9	-1.0	-1.0	-2.3
Neuroticism score	1.7	3.5	8.2	1.7	-2.1	-2.9	-1.8	1.4	0.1
Length of working week for main job	1.7	1.9	6.8	0.9	-1.5	-2.6	-1.0	-0.4	0.5
Neck or shoulder pain in last month	1.7	2.4	4.9	-0.3	-1.2	-1.8	-2.2	-1.1	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	4.4	-2.1	-1.1	-1.1	-1.4	-1.5	-1.0
Ovarian Cancer	1.6	2.2	5.2	-1.4	-2.3	-0.6	-2.1	-1.1	-0.2
Medication: Simvastatin	1.6	2.3	5.8	-1.4	-2.4	-1.1	-1.5	-1.5	-0.9
Alcohol intake versus 10 years previously	1.6	2.3	5.1	2.2	-1.9	-2.3	0.0	0.2	-0.1
Medication: Ibuprofen	1.6	1.9	4.6	0.1	0.3	-1.7	-1.7	-0.9	-2.1
Had major operations	1.6	1.9	4.4	1.6	0.7	-0.4	1.3	2.1	1.4
Diabetes (mother)	1.5	1.9	3.9	0.0	-1.5	-2.0	-0.9	-1.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.7	-1.8	0.1	0.7	0.5	-1.3	-2.2
Age at last live birth	1.5	2.1	6.7	0.8	0.6	2.1	2.6	0.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	6.1	-2.5	0.7	0.3	-1.3	-0.9	1.0
Neuroticism (Nagel 2018)	1.4	3.3	6.2	1.4	-2.3	-2.5	-1.9	1.8	0.0
Ever had hysterectomy (womb removed)	1.4	1.6	3.4	-1.6	0.1	1.3	-0.6	-1.2	-1.8
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	6.7	2.6	-1.2	-1.1	1.1	0.8	1.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.8	4.7	0.1	-0.9	-2.2	-1.6	0.5	1.4
Heart disease (siblings)	1.4	1.7	5.5	0.3	-2.3	-1.6	-1.4	-0.2	0.3
Verbal and Numeric Reasoning (VNR)	1.3	3.0	8.1	-0.4	1.5	2.5	2.9	-1.1	-0.6
LDL Cholesterol	1.3	2.1	7.9	0.3	0.0	-1.9	-2.8	-0.9	-0.1
Smoking Status	1.3	3.2	11.6	0.5	-2.0	-3.4	-1.3	1.0	0.5
Neuroticism	1.3	3.2	6.5	1.7	-2.2	-2.5	-1.7	1.4	-0.5
Diabetes (father)	1.3	1.6	4.7	1.6	0.2	0.4	1.0	2.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	4.6	0.6	-1.4	-2.1	-1.4	1.0	0.3
Pulse wave Arterial Stiffness index	1.3	1.6	4.0	1.3	-1.4	-0.1	0.9	0.9	2.0
Headache pain in last month	1.3	2.2	6.0	1.5	-2.5	-1.5	-1.0	0.3	-1.2
Age at first live birth	1.3	2.4	6.3	1.7	0.9	1.4	2.5	0.8	1.3
Pulse wave peak to peak time	1.3	1.6	3.4	-1.4	1.4	-0.0	-0.8	-1.3	-1.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.6	-1.7	0.3	0.6	-0.2	-0.8	-2.1
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	4.0	2.0	-1.4	-1.5	0.9	0.3	1.1
Mean Putamen Volume	1.2	1.4	3.7	-0.9	1.5	1.2	0.3	1.9	0.3
Body mass index (BMI)	1.2	4.9	9.1	2.3	-3.0	-1.4	-1.8	2.2	2.3
Number of incorrect matches in round	1.2	2.0	6.1	-2.5	0.3	1.0	0.3	-2.0	-0.8
Medication: Allopurinol	1.2	1.6	5.2	-1.5	1.0	0.7	-0.1	0.7	2.3
Average weekly red wine intake	1.2	1.8	4.2	-0.6	1.6	2.0	1.8	-0.3	-0.6
Impedance of whole body	1.2	5.9	14.4	-3.8	1.4	-0.3	-2.2	-2.7	-2.6
Schizophrenia (2018)	1.1	2.2	5.7	0.3	1.2	2.3	2.4	0.8	0.5
Worry (Nagel 2018)	1.1	2.3	5.6	1.4	-1.5	-1.4	-1.4	2.4	-0.3
Reaction Time	1.1	2.0	5.1	0.4	1.1	1.9	0.5	1.4	2.3
Number of treatments/medications taken	1.1	2.0	3.6	1.9	-1.6	-1.2	-1.4	1.2	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	5.0	0.6	-1.9	-2.2	-0.8	0.6	-0.5
Noisy workplace	1.1	1.4	2.9	1.7	-0.6	-1.3	0.7	1.2	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.1	-0.2	0.3	1.8	1.3	-0.9	-1.3
Comparative body size at age 10	1.1	3.0	7.2	-2.4	-1.6	-1.3	-2.7	-0.5	-0.5
Medication: Seretide 50 evohaler	1.1	1.3	4.5	1.3	0.0	-0.8	-0.1	2.1	1.0
Mean time to correctly identify matches	1.1	2.1	6.0	0.3	0.5	2.5	1.4	1.3	1.6
Mood swings	1.1	2.1	4.9	1.5	-2.2	-1.9	0.1	1.3	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	4.2	-1.0	0.7	-0.2	-2.0	-0.9	0.9
Medication: Bendroflumethiazide	1.1	1.6	3.0	1.7	-0.5	1.1	1.5	1.4	1.0
Alcohol drinker status: Never	1.1	1.3	3.6	1.3	-1.3	-0.9	0.2	1.9	-0.4
Cholesterol lowering medication	1.1	1.6	2.9	-1.0	-1.6	-0.8	-0.9	-1.2	-1.7
Schizophrenia vs Biploar Disorder	1.0	1.4	3.0	-1.4	1.7	1.5	-0.3	-0.8	0.1
Coronary Artery Disease (CAD)	1.0	1.2	3.3	-1.1	1.8	1.4	-0.8	0.7	0.1
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.9	2.0	-0.4	-1.3	0.5	1.1	-0.8
Average weekly fortified wine intake	1.0	1.1	4.3	0.5	2.1	0.4	1.4	-0.1	-0.0
Fluid intelligence score	1.0	2.1	7.6	1.0	1.0	1.7	2.8	0.4	-0.1
Arm fat percentage (right)	1.0	4.1	7.9	1.0	-2.8	-1.4	-2.8	1.7	1.8
Time employed in main current job	1.0	1.1	2.2	-1.4	-0.6	-0.2	-1.2	-1.5	0.8
Number of live births	1.0	1.4	3.8	-1.2	0.3	-0.1	-1.8	-1.9	-0.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.6	0.0	-0.9	-0.7	-1.6	1.0	1.5
Gout (self-reported)	1.0	1.3	4.7	-0.5	0.9	-0.3	-1.2	0.7	2.2
Medication: Amlodipine	1.0	1.4	3.0	0.7	-0.8	-1.1	-1.3	1.7	1.0
Birth weight	1.0	2.1	5.9	-1.1	1.0	2.4	1.0	-0.6	-1.8
Exposure to tobacco smoke outside home	1.0	1.4	5.1	0.8	-2.2	-0.2	-0.1	1.6	-0.2
Smoking status: Previous	1.0	1.5	3.5	-0.5	-1.3	-1.5	-1.9	-0.8	0.9
Arm fat percentage (left)	1.0	3.8	7.1	1.1	-2.6	-1.2	-2.7	1.7	1.9
Financial situation satisfaction	1.0	1.2	2.2	1.5	0.1	-1.4	-0.6	1.5	0.7
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.8	0.8	-0.9	-0.3	-1.4	2.0	-0.2
Number of operations (self-reported)	1.0	1.5	3.2	1.5	-1.0	-1.8	0.9	1.4	0.5
Fractured/broken bones in last 5 years	1.0	1.2	2.6	1.2	-1.6	-1.2	0.5	0.9	0.8
Diastolic blood pressure, automated reading	1.0	3.0	6.8	0.4	-2.3	-2.6	-2.0	0.8	1.1
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.4	-0.7	2.5	1.9	2.3	-0.6	-0.7
Basal cell carcinoma (self-reported)	1.0	1.2	2.5	-0.6	0.2	-1.1	-1.1	-1.3	-1.6
HbA1C	0.9	1.0	3.5	-0.5	0.4	0.9	-0.7	0.7	1.9
Type 2 Diabetes (T2D) (2018)	0.9	1.8	4.0	0.2	-1.6	-0.8	-2.0	-0.0	-1.8
Hand grip strength (left)	0.9	2.5	9.6	-1.8	-0.3	-0.4	-0.7	-3.1	-1.2
Vitamin and mineral supplements	0.9	1.2	4.3	-1.4	0.5	0.2	-0.7	0.1	-2.1
Maternal smoking around birth	0.9	1.2	5.7	0.5	-2.4	-0.9	0.1	0.0	0.8
Financial difficulties in last 2 years	0.9	1.2	3.5	-0.4	-1.9	-1.5	-1.1	0.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	4.1	0.7	-1.8	-2.0	-0.7	-0.1	0.0
Loud music exposure frequency	0.9	1.0	1.7	-1.1	0.8	-0.5	-1.3	-0.9	1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.3	-0.6	-1.0	-1.5	-1.2	-1.2	-0.5
Qualifications: College or University degree	0.9	3.0	8.9	0.9	2.0	2.0	3.0	-0.1	-0.3
Emphysema/chronic bronchitis	0.9	1.0	2.8	-0.4	-1.2	-1.7	-0.9	0.4	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.0	-0.6	1.7	0.6	0.3	0.6	1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.4	0.9	1.9	0.7	0.7	1.1	0.6
Bipolar Disorder or Schizophrenia	0.8	2.0	6.5	0.5	1.0	1.6	2.5	0.7	-1.0
Alzheimer’s Disease (in mother)	0.8	1.0	4.3	0.5	0.4	0.4	2.1	1.0	0.4
Ulcerative Colitis (UC)	0.8	1.6	4.5	-0.6	-0.5	0.7	-0.6	-1.9	-2.1
Prostate Cancer	0.8	1.1	2.5	1.4	-1.6	-1.2	-0.4	0.8	0.1
Schizophrenia (2014)	0.8	1.8	4.6	-0.3	1.4	2.2	1.9	0.1	-0.4
BMI	0.8	4.4	8.0	2.8	-2.2	-1.9	-1.5	2.1	1.8
Respiratory disease	0.8	1.8	4.1	1.8	0.2	0.0	1.4	1.3	2.0
Supplements: Zinc	0.8	0.9	2.3	1.2	-1.1	-1.5	0.4	-0.3	0.3
Pack years adult smoking proportion	0.8	1.2	3.7	-0.9	-0.6	-0.9	-1.9	-1.2	0.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.6	-1.3	1.1	1.1	0.7	-0.2	-0.7
High blood pressure	0.8	2.1	4.4	0.8	-2.1	-1.6	-1.7	0.7	1.1
Multivitamins +/- minerals	0.8	1.1	2.4	0.7	-0.9	-1.6	-0.6	0.2	1.4
Supplements: Glucosamine	0.8	1.1	3.5	0.9	-1.1	0.0	0.9	1.9	-0.5
Past tobacco smoking	0.8	1.4	3.3	1.3	1.0	1.2	1.8	0.9	-0.8
Hair/balding pattern: Pattern 2	0.8	1.0	3.7	-0.5	-0.2	0.8	-0.2	-1.9	-1.1
Medication: Ramipril	0.8	1.0	1.9	1.3	-1.1	-0.6	0.7	0.3	-1.4
Medication: Lansoprazole	0.8	0.9	2.0	-1.1	-1.4	-0.5	-1.1	-1.0	-0.1
Illnesses of mother	0.8	0.9	2.8	-0.5	1.4	1.7	0.3	-0.4	0.6
Arm fat mass (right)	0.8	3.5	5.6	1.6	-2.4	-1.1	-2.1	1.6	2.2
Breastfed as a baby	0.8	1.0	3.5	-1.3	0.4	1.9	-0.0	-0.3	0.5
Tense / ‘highly strung’	0.8	1.3	2.9	0.0	-0.7	-1.3	-1.6	0.4	-1.7
Pulse wave reflection index	0.8	1.0	2.5	1.3	-1.3	-0.1	0.4	0.3	1.6
Blood clot in the leg (DVT)	0.8	1.0	2.7	1.6	-1.0	-1.2	0.9	0.2	0.6
Glaucoma (self-reported)	0.8	0.9	2.8	0.1	-0.4	-1.1	-0.6	-1.1	-1.7
Body fat percentage	0.8	3.0	8.5	0.4	-2.3	-1.1	-2.9	1.3	1.1
Number of full brothers	0.8	1.1	2.5	-0.9	-0.1	-1.1	-1.6	-1.2	-0.6
Migraine (self-reported)	0.8	1.0	2.1	-0.1	0.6	1.4	1.2	0.9	-1.0
Leg fat mass (right)	0.8	3.0	6.1	1.0	-2.1	-1.1	-2.5	1.3	2.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.0	-1.1	-1.4	-0.7	0.2	0.0	1.2
Illnesses of father: Heart disease	0.8	1.2	3.1	0.9	-0.9	-1.4	-1.8	-0.4	0.4
Qualifications: nursing, teaching	0.8	1.2	2.2	-1.4	1.4	1.5	-0.2	-0.4	-0.8
Mineral and other dietary supplements	0.8	1.0	4.4	-0.7	2.1	0.7	-0.5	0.1	0.7
Breast cancer (self-reported)	0.8	0.9	2.1	-0.6	0.2	-1.1	-0.0	-1.5	1.4
Osteoporosis (self-reported)	0.8	1.0	2.4	0.2	-0.8	-0.7	1.0	-1.3	-1.5
Arm fat mass (left)	0.8	3.3	5.2	1.6	-2.3	-1.2	-2.2	1.4	2.0
Leg fat percentage (left)	0.8	2.7	6.5	0.5	-2.3	-1.1	-2.6	1.4	1.1
Ever depressed for a whole week	0.8	0.9	4.1	0.7	-0.7	0.4	0.7	2.0	-0.1
Leg fat mass (left)	0.8	3.3	5.9	1.3	-2.2	-1.2	-2.4	1.4	1.9
Crohns Disease (2012)	0.7	1.1	4.4	0.4	-0.5	-1.1	0.4	-0.4	-2.1
Rheumatoid Arthritis	0.7	1.0	1.9	1.3	0.6	0.1	1.0	1.0	1.4
Trunk fat percentage	0.7	2.9	9.2	0.5	-2.1	-1.1	-3.0	1.1	1.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.5	-1.6	-0.0	0.9	-0.1	-0.6	-1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.5	-1.6	0.1	0.6	-0.4	-1.4	0.4
Chronic bronchitis/emphysema (father)	0.7	0.8	2.7	-0.6	-1.1	-1.6	-0.7	-0.5	-0.1
Hearing difficulty/problems with background noise	0.7	1.0	3.7	0.1	-0.6	-1.4	-1.9	-0.1	-0.4
Mouth/teeth dental problems	0.7	1.1	2.6	0.3	1.0	1.6	1.4	-0.6	-0.7
Impedance of arm (right)	0.7	3.5	8.1	-2.8	0.7	-0.8	-2.2	-2.0	-1.7
Worrier / anxious feelings	0.7	1.4	5.5	1.4	-0.7	-0.4	-0.6	2.4	-0.0
Hair/balding pattern: Pattern 3	0.7	1.1	3.1	-0.5	1.8	0.4	1.5	0.8	0.1
Pulse rate	0.7	1.3	2.4	0.8	1.6	0.1	1.4	1.4	0.8
Impedance of arm (left)	0.7	3.4	7.4	-2.7	1.1	-0.3	-1.7	-2.2	-2.0
Leg fat percentage (right)	0.7	2.5	6.8	-0.1	-2.3	-0.9	-2.6	1.1	0.9
Eye problems/disorders: None of the above	0.7	0.8	1.7	-0.8	0.1	1.3	1.3	0.5	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.1	2.6	0.9	0.4	0.6	1.6	0.8	1.5
Whole body fat mass	0.7	3.0	6.3	1.1	-2.2	-1.1	-2.5	1.4	1.6
Alcohol intake frequency.	0.7	1.6	3.6	1.0	-1.9	-1.7	-0.8	1.2	0.4
Leg fat-free mass (right)	0.7	3.7	11.8	3.4	-0.6	-0.6	0.0	1.7	2.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.9	1.4	-0.6	-0.9	1.3	1.3	-0.2
Medication: Gliclazide	0.7	0.8	2.2	0.1	-0.6	-1.0	-1.0	0.0	-1.5
Leg predicted mass (right)	0.7	3.7	11.7	3.4	-0.6	-0.6	0.1	1.7	2.6
Number of self-reported non-cancer illnesses	0.7	1.1	2.1	1.3	-0.6	-0.9	-0.6	1.4	1.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.3	0.1	-1.0	-0.7	-1.5	0.5	-1.0
Medication: Lisinopril	0.7	1.0	3.4	-0.3	0.5	1.0	0.7	-0.8	-1.9
Illnesses of father: High blood pressure	0.7	0.8	4.5	0.3	-0.2	0.1	0.1	0.7	2.1
Pack years of smoking	0.7	1.1	3.3	-1.1	-0.3	-0.9	-1.8	-1.0	0.5
Bipolar Disorder (2018)	0.6	1.0	4.5	0.5	0.2	-0.3	1.1	0.1	-2.1
Alzheimer’s Disease (including proxy)	0.6	0.9	1.7	1.0	-0.3	0.0	1.3	1.1	1.1
Irritable Bowel Disease (IBD)	0.6	1.5	6.0	-0.4	-0.2	0.5	-0.1	-1.5	-2.5
Fasting Glucose	0.6	0.7	1.2	-1.0	-0.6	0.1	-0.7	-1.1	-1.1
Primary Biliary Cirrhosis	0.6	0.9	2.1	-1.0	-0.2	0.5	-1.4	1.4	-0.4
Ulcerative Colitis	0.6	0.8	2.5	-0.4	-0.6	0.4	-0.2	-1.4	-1.6
Sensitivity / hurt feelings	0.6	1.0	2.3	-0.1	-1.4	-1.3	-1.5	0.0	0.0
Leg fat-free mass (left)	0.6	3.3	9.5	3.1	-0.6	-0.6	-0.2	1.5	2.6
High blood pressure (mother)	0.6	0.9	2.1	-0.8	-1.4	-0.7	-1.5	-0.0	-0.4
Leg predicted mass (left)	0.6	3.3	9.5	3.1	-0.7	-0.6	-0.2	1.6	2.6
Trunk fat mass	0.6	2.4	6.2	0.9	-1.8	-0.9	-2.5	1.1	1.4
Had menopause	0.6	0.8	2.2	-1.2	-0.2	1.5	0.5	0.5	0.6
Wheeze or whistling in the chest in last year	0.6	1.1	2.4	0.9	-0.1	0.2	1.4	1.2	1.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	3.1	0.2	0.2	-1.8	-0.7	0.7	-0.1
Chest pain or discomfort	0.6	0.9	1.3	0.9	-1.2	0.2	0.7	1.0	1.2
Knee pain experienced in last month	0.6	0.9	2.6	-0.6	-1.0	-0.2	-1.6	1.2	-0.2
Hypertension (Self-reported)	0.6	1.7	3.2	0.6	-1.8	-1.6	-1.6	0.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.2	-0.4	1.8	1.1	-0.9	-1.2	0.7
Friendships satisfaction	0.6	0.7	2.4	0.4	0.9	-0.4	0.8	0.2	1.6
Commuting to job workplace: Walk	0.6	0.7	1.8	-0.5	1.1	1.3	-0.1	-0.6	0.6
Guilty feelings	0.6	0.9	1.9	0.1	0.3	-1.4	-1.4	0.6	1.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.2	-0.4	-1.0	-0.6	0.1	-1.0	-1.5
Irritability	0.6	1.1	2.1	1.4	0.2	-1.3	0.0	0.7	1.4
Unable to work because of sickness or disability	0.6	0.8	2.2	-0.5	-1.3	-0.8	-0.0	-1.5	-0.4
Commuting to job workplace: Cycle	0.6	0.8	2.6	-0.5	0.9	1.6	0.0	-0.9	-0.5
Intelligence (Savage-Jansen 2018)	0.5	1.7	4.0	-1.0	1.3	1.6	2.0	-0.9	0.1
Blood Red Count	0.5	5.0	8.9	2.5	-2.9	-1.6	1.6	3.0	1.3
Hypothyroidism (self reported)	0.5	1.2	3.0	0.7	0.9	1.7	1.4	0.2	-1.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.9	0.3	0.3	-0.0	0.0	-1.7	-0.3
Severe depression (siblings)	0.5	0.6	1.3	0.7	-0.1	-0.4	0.5	1.0	1.2
Hand grip strength (right)	0.5	1.3	4.0	-0.2	-1.0	-1.2	-0.8	-2.0	-0.9
Age when periods started (menarche)	0.5	1.1	3.6	1.9	-0.3	-0.5	1.3	0.4	-1.0
Stomach or abdominal pain in last month	0.5	0.6	2.5	0.5	0.6	-0.0	-0.7	1.6	0.4
Sitting height	0.5	3.5	9.7	-0.0	3.1	1.9	1.8	-1.7	-1.2
Waist circumference	0.5	2.0	4.4	0.8	-1.7	-0.5	-1.6	1.0	2.1
Nervous feelings	0.5	1.0	1.9	0.9	-0.9	-0.9	-0.6	1.1	-1.4
Had other major operations	0.5	0.6	2.5	-0.6	0.1	0.1	1.6	-0.9	0.2
Pain all over the body in last month	0.5	0.5	1.5	-1.2	0.1	0.6	-0.3	0.4	1.0
Diabetes (self-reported)	0.5	0.7	1.6	0.5	-1.3	-0.4	-1.2	0.9	-0.5
Hip circumference	0.5	2.4	4.9	2.0	-2.2	-1.0	-1.6	0.6	1.2
Mouth/teeth dental problems: Dentures	0.5	0.8	2.2	-0.1	-0.9	-0.0	-1.5	1.0	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.4	-0.2	0.8	-0.9	-1.2	-0.3	-1.1
Prospective memory result	0.5	0.6	1.2	0.2	-0.2	1.1	1.1	1.1	-0.1
Peak expiratory flow (PEF)	0.5	1.1	3.0	-0.2	-1.0	-1.4	-1.7	0.0	0.5
High blood pressure (siblings)	0.5	0.8	3.3	-0.5	-0.3	-0.8	-1.8	-0.4	0.3
Heart disease (mother)	0.5	0.6	1.9	0.3	-0.1	0.6	-0.4	0.9	1.4
Supplements: Vitamin C	0.5	0.5	2.3	1.5	-0.2	-0.3	0.3	-0.8	0.3
Illnesses of siblings: Diabetes	0.5	0.6	2.2	-0.2	0.1	1.5	0.6	0.5	-0.7
Ever had bowel cancer screening	0.5	0.6	3.1	0.2	0.4	0.5	1.8	0.4	0.2
Whole body water mass	0.5	2.6	8.8	3.0	0.0	-0.0	0.8	1.0	2.2
Wears glasses or contact lenses	0.5	0.6	2.7	-0.2	-0.4	1.6	0.9	0.1	0.4
Commuting to job workplace: Public transport	0.5	0.6	1.6	1.3	0.5	-0.0	1.2	-0.5	0.5
Medication: Blood pressure	0.5	0.9	2.0	1.4	-1.3	-1.2	-0.3	-0.1	0.3
Alzheimer’s Disease (in father)	0.4	0.4	1.7	0.2	0.2	0.5	-0.5	0.4	1.3
Crohns Disease (2017)	0.4	1.0	5.1	-0.3	0.3	0.0	-0.1	-0.7	-2.3
HDL Cholesterol	0.4	0.7	2.4	-0.0	0.0	1.0	1.5	0.7	-0.5
Triglycerides	0.4	0.6	1.6	-0.1	-0.9	-1.0	-1.3	0.1	0.3
Cardiovascular Disease	0.4	1.4	5.1	0.1	-0.2	-1.4	-2.2	0.9	-0.6
Systolic blood pressure, automated reading	0.4	1.2	3.3	0.1	-1.8	-1.1	-1.3	0.7	-0.6
Angina	0.4	0.6	2.2	0.1	-1.5	-0.5	-0.9	0.4	-0.1
Allergy	0.4	1.0	2.6	-0.7	-0.6	-1.0	-1.6	0.1	-1.2
Weight	0.4	2.1	3.9	1.9	-1.4	-0.8	-1.2	1.0	2.0
Falls in the last year	0.4	0.6	1.4	-0.1	-0.4	-0.8	-0.9	0.8	1.2
Medication: Cholesterol lowering	0.4	0.6	1.5	-1.1	-0.1	0.4	-1.2	-0.3	-0.7
Trunk predicted mass	0.4	2.1	6.5	2.5	0.5	0.2	1.2	0.5	1.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.6	0.7	0.4	0.3	1.6	-0.1	0.6
Arm fat-free mass (right)	0.4	2.0	6.7	2.6	-0.1	0.1	0.6	0.7	2.1
Angina (self-reported)	0.4	0.5	1.7	-0.1	-1.3	-0.5	-1.0	0.3	-0.2
Arm predicted mass (right)	0.4	2.0	6.9	2.6	0.1	0.4	0.9	0.8	1.8
Pulse rate, automated reading	0.4	1.3	4.4	0.3	2.1	0.2	0.8	0.7	1.5
Whole body fat-free mass	0.4	2.5	8.8	3.0	0.0	-0.1	0.7	1.0	2.2
Loneliness, isolation	0.4	0.5	1.1	0.1	-0.4	-0.9	-0.5	0.9	1.1
Diabetes diagnosed by doctor	0.4	0.7	1.6	0.4	-1.3	-0.3	-1.2	0.3	-0.9
Average weekly champagne plus white wine intake	0.4	0.5	2.9	0.4	0.1	-0.2	-0.1	-0.0	1.7
Ever taken oral contraceptive pill	0.4	0.4	0.8	-0.8	-0.4	0.1	-0.9	-0.5	0.8
Mother’s age at death	0.4	0.4	1.2	-0.4	1.1	0.3	0.7	0.2	-0.8
Medication: Atorvastatin	0.4	0.5	2.2	0.0	-0.6	-0.0	-0.7	1.5	0.2
Ever smoked	0.4	0.6	1.7	-1.3	0.2	-0.3	-1.2	-0.7	0.1
Basal metabolic rate	0.4	2.5	7.9	2.8	-0.4	-0.3	0.2	1.1	2.3
Arm fat-free mass (left)	0.4	2.3	8.6	2.9	-0.3	-0.1	0.6	1.2	1.7
Pain experienced in last month	0.4	0.7	2.7	0.3	1.6	0.1	1.0	-0.8	-0.0
Arm predicted mass (left)	0.4	2.1	7.9	2.8	-0.4	-0.1	0.6	1.1	1.8
Breast Cancer	0.3	0.6	2.0	0.4	-1.4	-0.1	-0.6	-0.7	0.9
Bipolar Disorder (2011)	0.3	0.3	1.6	0.2	0.6	-0.1	-0.2	-0.1	-1.2
Body Mass Index (BMI) (2010)	0.3	0.4	1.9	-0.3	1.4	0.4	-0.1	-0.5	-0.4
Waist Hip Ratio (WHR)	0.3	1.4	6.4	-2.5	1.2	0.4	-0.3	-0.7	0.0
Systolic Blood Pressure	0.3	1.7	4.5	-0.2	-2.0	-1.2	-2.1	0.7	-0.2
Allergy or Eczema	0.3	0.8	2.0	-0.3	0.5	1.4	0.7	-1.2	-0.4
Lung FEV1/FVC ratio	0.3	1.8	4.0	-0.2	-1.8	-1.4	-0.7	-2.0	-0.9
Tanning	0.3	3.1	5.9	0.3	1.1	2.1	1.9	2.4	1.9
Medication for hormone replacement therapy	0.3	0.3	1.0	-0.6	0.3	0.0	-0.5	1.0	-0.3
Current tobacco smoking	0.3	0.5	1.7	-0.5	-0.1	-1.3	-0.6	0.6	-0.3
Relative age voice broke	0.3	0.5	1.1	-0.3	-1.0	-0.8	0.6	0.0	-0.8
Qualifications: CSEs or equivalent	0.3	0.3	1.3	0.4	-1.1	-0.5	-0.0	0.5	0.4
Medication: Levothyroxine sodium	0.3	0.4	1.7	0.0	-0.4	0.0	-0.6	-0.7	-1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.0	-0.4	-0.6	0.7	-0.3	1.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.5	0.3	-0.2	1.2	0.6	-0.0	0.2
Illnesses of siblings	0.3	0.4	0.9	0.1	1.0	0.0	0.9	0.8	-0.0
Trunk fat-free mass	0.3	1.8	6.0	2.4	0.5	0.2	1.2	0.5	1.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.3	0.6	0.3	0.8	1.5	-0.4	0.5
Standing height	0.3	3.4	9.9	-0.7	3.1	1.3	0.9	-2.6	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.7	0.7	-0.4	-0.5	-0.1	1.3	0.3
Birth weight of first child	0.3	0.6	1.8	0.1	0.5	-0.7	-0.3	0.9	1.3
Worry too long after embarrassment	0.3	0.6	2.1	0.3	0.7	-0.6	-1.5	0.5	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.6	0.1	-0.0	-0.1	0.6	1.3	0.2
Medication: Blood pressure	0.3	0.5	1.5	0.2	-1.1	-0.1	-1.2	0.7	-0.0
Comparative height size at age 10	0.3	1.8	4.7	-0.7	2.2	1.3	1.0	-1.6	0.3
Family relationship satisfaction	0.3	0.4	1.2	0.2	1.1	-0.5	0.4	0.8	0.2
Leg pain on walking	0.3	0.4	1.2	0.1	1.1	-0.5	-0.2	-0.9	-0.4
Eye problems/disorders: Cataract	0.3	0.3	1.0	-0.4	0.3	-0.4	-1.0	-0.1	0.6
Back pain experienced in last month	0.3	0.4	0.8	-0.4	-0.9	0.1	0.5	0.8	0.8
Smoking status: Current	0.3	0.4	1.5	-0.8	-0.2	-1.2	-0.6	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	1.1	-1.0	-0.7	-0.6	0.4	0.8
Eye problems/disorders: Glaucoma	0.3	0.4	1.6	0.1	0.4	-0.4	-0.6	-0.1	-1.3
High cholesterol (Self-reported)	0.3	0.6	1.7	-0.8	-0.1	-0.6	-0.7	-0.4	-1.3
Risk taking	0.3	0.4	0.9	-0.1	0.6	0.4	0.6	-0.9	1.0
Alcohol drinker status: Previous	0.3	0.4	0.8	-0.3	-0.7	0.8	0.3	0.9	-0.5
Lupus	0.2	0.3	0.4	-0.6	0.5	0.6	0.5	0.1	0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.9	0.4	-0.4	0.2	-1.0	0.2	-0.5
Blood Eosinophil Count	0.2	1.9	5.2	-2.3	1.7	1.8	-0.1	-0.3	-0.1
Height	0.2	3.2	14.4	-1.1	3.8	1.4	0.4	-1.3	-0.1
Hearing difficulty/problems: Yes	0.2	0.3	1.1	-0.3	-1.1	-0.1	0.3	-0.7	0.1
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.0	-0.2	0.3	1.0	0.5	-0.5	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.7	-0.3	0.6	-0.9	-1.0	-1.6	-0.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	0.9	-0.0	0.1	0.9	1.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	0.9	-0.4	0.5	0.6	0.0	-0.6
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.5	0.3	0.7	0.1	0.7	0.4
Number of full sisters	0.2	0.3	0.4	-0.6	-0.5	0.6	0.1	-0.5	-0.6
Long-standing illness, disability or infirmity	0.2	0.2	0.9	0.2	0.9	0.7	0.2	-0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	-0.5	-0.1	-0.8	-0.3	0.3	0.0
Osteoarthritis (self-reported)	0.2	0.2	1.1	0.2	0.5	-0.2	-0.1	1.0	0.1
Hearing aid user	0.2	0.2	0.4	0.4	0.4	0.2	0.4	0.6	0.5
Medication: Paracetamol	0.2	0.3	0.8	0.5	0.3	0.3	-0.9	-0.8	-0.5
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.2	-0.6	-0.1	-0.6	0.6	0.7
Lung FVC	0.1	0.6	1.4	-0.6	1.0	0.5	1.2	-0.1	-0.8
Average weekly spirits intake	0.1	0.2	0.6	-0.8	0.3	0.0	-0.4	0.3	0.3
Relative age of first facial hair	0.1	0.1	0.3	0.2	0.2	-0.3	0.3	0.4	-0.6
Medication: Metformin	0.1	0.2	0.6	0.4	-0.0	-0.1	-0.8	-0.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.7	0.4	0.2	-0.6	-0.0	0.1
Forced vital capacity (FVC)	0.1	0.5	1.9	-0.2	1.4	-0.5	-0.2	-1.0	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	-0.6	0.9	0.6	-0.5	-0.4	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.1	1.0	0.2	-0.4	0.3	-0.8	0.4
Medication: Paracetamol	0.1	0.2	0.5	0.2	0.4	0.7	-0.5	-0.5	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.4	1.4	0.8	1.2	0.2	0.5	-0.2	0.2
Medication for cholesterol	0.1	0.1	0.3	-0.3	0.4	0.5	0.2	-0.4	-0.4
Illnesses of father: None of the above (group 1)	0.1	0.2	0.6	0.3	0.3	-0.8	-0.4	0.4	0.1
Blood White Count	0.0	0.3	1.1	0.1	-0.3	-0.1	-1.0	-0.6	-0.4
Heel T-Score	0.0	0.3	1.1	0.3	0.2	-0.1	0.7	1.1	0.0
Hair Pigment	0.0	0.2	0.5	-0.3	0.3	0.4	-0.7	-0.4	-0.6

Hub : Genes

PEX12

Models

Trait associations