TWAS hub - AP2B1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0820	0.0210	2.6e-08	0.099	0.077	0.077	0.082	0.079	4.9e-12	1.1e-09	1.1e-09	3.4e-10	6.4e-10
2	GTEx	Muscle Skeletal	0.1157	0.0283	2.0e-10	0.109	NA	0.133	NA	0.124	7.9e-11	NA	5.4e-13	NA	3.3e-12
3	GTEx	Testis	0.2910	0.0720	2.8e-06	0.129	NA	0.094	NA	0.147	2.5e-06	NA	6.1e-05	NA	4.6e-07
4	METSIM	Adipose	0.0517	0.0212	4.4e-03	0.001	0.019	0.014	0.023	0.006	1.8e-01	6.2e-04	3.1e-03	1.9e-04	3.1e-02
5	YFS	Blood	0.0218	0.0080	2.4e-04	0.015	0.009	0.006	0.011	0.011	9.4e-06	4.3e-04	2.5e-03	9.5e-05	1.0e-04
6	TCGA	Brain Lower Grade Glioma	0.0249	0.0157	7.4e-03	0.025	0.016	0.011	NA	0.017	7.1e-04	5.6e-03	1.6e-02	NA	4.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Chronotype (morning person)	11.4	26.4	41.1	6.4	4.4	5.5	3.7	4.6	5.7
Age at First Birth	6.5	9.4	12.0	3.5	3.4	3.4	3.1	0.9	3.3
Blood Platelet Count	5.9	68.8	204.5	-8.0	1.7	-7.6	-6.2	-14.3	-6.7
Medication: Atenolol	5.9	7.4	10.5	-3.1	-2.9	-3.2	-2.1	-1.1	-3.1
Overall health rating	5.0	10.6	17.5	-3.8	-4.2	-3.6	-1.9	-0.5	-3.8
Myopia	5.0	7.2	10.7	3.3	3.2	3.2	1.3	0.8	3.1
Qualifications: None of the above	4.8	10.4	14.1	-3.7	-3.6	-3.8	-2.2	-1.8	-3.7
Father’s age at death	4.6	6.2	9.9	2.9	2.8	3.0	1.3	-0.3	3.1
Depression (Nagel 2018)	4.4	6.7	11.0	-3.1	-3.3	-2.8	-2.0	0.6	-2.8
Age started oral contraceptive pill	4.3	5.4	8.5	2.8	1.9	2.9	2.3	0.4	2.6
Chronic bronchitis/emphysema (mother)	3.8	4.4	6.7	-2.4	-2.6	-2.5	-1.3	0.9	-2.2
Neuroticism (2016)	3.7	5.3	9.5	-2.3	-3.1	-2.7	-1.9	0.0	-2.6
Age at last live birth	3.7	5.4	8.1	2.7	2.5	2.8	1.3	1.3	2.8
LDL Cholesterol	3.5	5.5	8.2	-2.9	-2.5	-2.8	-1.7	-0.4	-2.9
Smoking Status	3.5	8.3	12.8	-3.1	-3.2	-3.0	-3.6	0.4	-2.9
Medication: Simvastatin	3.3	4.8	5.4	-2.3	-2.2	-2.0	-2.1	-2.3	-2.3
Medication: Omeprazole	3.3	4.0	6.6	-2.5	-2.3	-2.6	-0.8	-0.0	-2.2
Miserableness	3.3	5.8	8.5	-2.4	-2.9	-2.7	-1.7	2.0	-2.4
Frequency of depressed mood in last 2 weeks	3.2	4.4	7.4	-2.2	-2.7	-2.1	-1.3	2.1	-2.0
Alcohol usually taken with meals	3.2	5.1	8.6	2.5	2.9	2.7	1.0	-1.2	2.5
Diabetes (mother)	3.1	4.0	5.4	-2.2	-2.2	-2.1	-2.3	-0.7	-2.0
Depression (self-reported)	3.0	3.6	5.1	-2.2	-2.3	-2.1	-1.3	1.3	-2.1
Length of working week for main job	3.0	3.3	4.8	-1.8	-2.2	-2.2	-1.5	0.6	-2.1
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	4.5	2.0	2.1	1.9	1.9	-0.1	2.0
Age at first live birth	2.8	4.9	6.1	2.5	2.0	2.3	1.9	2.2	2.5
Neck or shoulder pain in last month	2.6	3.6	6.0	-2.2	-2.2	-2.4	-0.7	-0.6	-2.4
Verbal and Numeric Reasoning (VNR)	2.5	6.1	9.1	2.9	2.8	3.0	1.5	0.7	2.9
Fed-up feelings	2.5	4.6	7.6	-2.5	-2.8	-2.6	-0.2	1.1	-2.5
Happiness	2.5	3.0	6.2	-1.6	-2.1	-1.6	-0.1	2.5	-1.4
Suffer from ‘nerves’	2.5	4.0	5.7	-2.1	-2.4	-2.1	-2.0	1.0	-2.1
Pack years of smoking	2.5	3.7	4.1	-1.9	-1.8	-1.9	-1.9	-2.0	-2.0
Mouth/teeth dental problems: Loose teeth	2.4	2.8	4.8	-1.9	-2.2	-1.8	-1.2	0.4	-2.0
Smoking status: Previous	2.4	3.6	4.6	-2.1	-1.8	-2.1	-1.9	-1.1	-2.1
Handedness (chirality/laterality): Left-handed	2.4	2.9	5.0	-2.2	-1.9	-2.0	-0.7	-0.9	-1.8
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	4.8	-2.2	-2.0	-2.1	-0.8	-0.2	-1.8
Depressed Affect (Nagel 2018)	2.3	4.9	8.7	-2.1	-3.0	-2.4	-1.7	1.5	-2.3
Pack years adult smoking proportion	2.3	3.5	3.8	-1.9	-1.7	-1.8	-1.9	-1.9	-2.0
Heart disease (siblings)	2.3	2.9	4.0	-1.9	-1.8	-1.9	-1.6	-0.1	-2.0
Heart attack	2.2	2.8	9.5	-1.4	-1.4	-1.2	-3.1	-0.5	-1.3
Emphysema/chronic bronchitis	2.2	2.4	4.2	-1.8	-2.1	-1.8	-0.5	-0.2	-1.9
Heart attack/myocardial infarction (self-reported)	2.2	2.9	9.9	-1.3	-1.4	-1.2	-3.1	-0.7	-1.3
Schizophrenia (2018)	2.1	4.4	6.5	2.3	2.5	2.5	1.2	0.5	2.5
Major Depression (MDD)	2.1	2.5	6.5	-1.8	-1.0	-1.3	0.6	-2.5	-1.6
Past tobacco smoking	2.1	3.9	6.9	2.2	1.5	1.8	2.6	1.8	1.8
Fluid intelligence score	2.1	4.4	6.4	2.5	2.0	2.5	1.3	1.4	2.5
Neuroticism score	2.1	4.4	6.9	-2.2	-2.6	-2.4	-1.0	1.6	-2.3
Qualifications: College or University degree	2.1	6.6	10.0	3.1	2.8	3.2	1.7	0.9	3.0
Medication: Ibuprofen	2.1	2.6	4.2	-1.7	-2.0	-2.0	-0.1	-0.2	-2.0
Chronic bronchitis/emphysema (father)	2.0	2.3	4.0	-1.4	-1.7	-1.3	-2.0	-0.6	-1.7
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	5.1	-1.9	-2.2	-2.1	-1.5	0.3	-2.0
Cholesterol lowering medication	2.0	2.9	5.9	-1.7	-2.0	-1.2	-0.6	-2.4	-1.8
Mean Putamen Volume	1.9	2.1	3.4	1.8	1.7	1.7	0.3	0.3	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	2.9	-1.6	-1.7	-1.5	-0.4	-1.6	-1.7
Average weekly red wine intake	1.9	2.8	4.4	2.0	1.9	2.1	0.8	0.3	2.0
Ovarian Cancer	1.8	2.4	5.3	-1.7	-1.2	-1.5	-0.2	-2.3	-1.6
Exposure to tobacco smoke at home	1.8	2.1	3.2	-1.8	-1.1	-1.4	0.6	-1.7	-1.6
Mouth/teeth dental problems	1.7	2.6	4.1	2.0	1.8	1.6	1.6	0.3	1.7
High blood pressure (siblings)	1.7	2.5	4.9	-1.7	-1.4	-2.1	-0.5	-0.6	-2.2
Number of children fathered	1.7	1.9	3.3	-1.3	-1.1	-1.1	-1.4	-1.8	-1.3
Medication: Bendroflumethiazide	1.7	2.6	3.9	2.0	1.2	1.8	1.9	0.8	1.7
Neuroticism (Nagel 2018)	1.6	3.7	5.2	-2.0	-2.3	-2.1	-1.3	1.4	-2.1
Schizophrenia (2014)	1.6	3.6	5.2	2.1	2.3	2.2	1.6	0.2	2.1
Neuroticism	1.6	3.9	6.1	-2.1	-2.5	-2.2	-1.2	1.4	-2.1
Diabetes (father)	1.6	2.0	4.1	1.2	0.8	1.1	1.7	2.0	1.2
Mean time to correctly identify matches	1.6	3.1	4.4	2.1	2.1	1.7	1.9	-0.4	1.8
Qualifications: nursing, teaching	1.6	2.5	5.3	1.5	1.6	1.7	2.3	-0.5	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.3	-1.8	-1.8	-1.5	-1.0	0.6	-1.4
Taking other prescription medications	1.5	2.3	3.8	-1.5	-1.9	-1.7	0.4	1.6	-1.6
Hearing difficulty/problems with background noise	1.5	2.4	3.6	-1.9	-1.7	-1.8	-1.1	-0.1	-1.8
Financial difficulties in last 2 years	1.5	2.0	3.1	-1.6	-1.7	-1.8	-0.9	0.4	-1.6
Lung cancer (father)	1.5	1.8	3.2	-1.5	-1.8	-1.5	-0.7	0.1	-1.5
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	4.6	-1.4	-1.2	-1.3	-2.1	0.2	-1.4
Comparative body size at age 10	1.5	4.2	6.7	-2.2	-2.0	-1.8	-1.7	-2.6	-1.9
Number of full brothers	1.5	1.9	3.6	-1.9	-1.1	-1.7	-0.7	-0.8	-1.6
Diastolic blood pressure, automated reading	1.5	4.7	6.8	-2.6	-2.2	-2.4	-2.3	0.6	-2.1
Vascular/heart problems diagnosed by doctor	1.5	4.1	6.0	2.2	2.2	2.2	1.7	0.8	2.5
Angina	1.4	1.8	2.5	-1.6	-1.5	-1.1	-1.5	-0.5	-1.5
Supplements: Zinc	1.4	1.6	2.7	-1.2	-1.6	-1.3	-0.7	1.1	-1.4
Townsend deprivation index at recruitment	1.4	1.9	2.7	-1.7	-1.6	-1.4	0.5	1.4	-1.4
Alcohol intake versus 10 years previously	1.4	2.0	3.3	-1.2	-1.8	-1.6	-0.2	1.6	-1.6
Prospective memory result	1.4	1.7	2.8	1.7	1.1	1.6	1.1	0.6	1.4
Birth weight	1.4	3.1	5.1	1.8	2.2	2.3	-0.3	-1.0	2.1
Angina (self-reported)	1.4	1.8	2.5	-1.5	-1.4	-1.1	-1.6	-0.7	-1.5
Migraine (self-reported)	1.4	1.7	2.9	1.5	1.2	1.7	0.9	-0.1	1.6
Sensitivity / hurt feelings	1.3	2.3	3.8	-1.9	-1.5	-1.6	-1.4	-0.2	-1.7
Ever had hysterectomy (womb removed)	1.3	1.5	6.8	0.2	0.7	0.5	1.2	-2.6	0.3
Illnesses of mother	1.3	1.6	3.9	1.3	2.0	1.2	0.5	-0.2	1.6
Commuting to job workplace: Cycle	1.3	1.5	2.7	1.1	1.6	1.4	0.4	-1.1	1.4
Bipolar Disorder or Schizophrenia	1.2	3.0	4.5	2.0	1.8	2.1	0.9	1.1	2.0
Hypothyroidism (self reported)	1.2	2.8	3.9	2.0	1.8	1.6	1.9	0.8	1.8
High blood pressure (mother)	1.2	1.6	2.4	-1.5	-1.5	-1.0	0.1	-1.5	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.0	-1.3	-1.7	-1.5	-1.5	0.4	-1.5
Number of live births	1.2	1.7	4.0	-1.3	-0.5	-1.4	-1.1	-2.0	-1.2
Asthma	1.2	2.3	3.8	1.9	1.4	1.4	1.3	1.4	1.6
Medication: Lansoprazole	1.2	1.3	2.4	-1.4	-1.1	-0.9	-0.0	-1.5	-1.2
Had major operations	1.2	1.4	5.3	0.8	0.5	0.8	0.9	2.3	0.9
Medication: Aspirin	1.2	1.5	2.6	-1.2	-1.6	-0.9	-1.1	-1.0	-1.4
Unable to work because of sickness or disability	1.2	1.5	2.8	-0.9	-1.4	-0.6	-1.6	-1.7	-0.9
Average weekly fortified wine intake	1.1	1.2	2.5	1.0	0.9	1.1	1.6	1.1	1.0
Breastfed as a baby	1.1	1.3	2.3	1.0	1.3	1.3	0.3	-1.5	1.1
Eye problems/disorders: None of the above	1.1	1.3	2.0	1.3	1.3	1.4	0.3	0.7	1.4
Asthma (self-reported)	1.1	2.2	3.6	1.9	1.4	1.5	1.2	1.1	1.6
Schizophrenia vs Biploar Disorder	1.0	1.3	2.5	0.9	1.6	1.2	1.0	-1.1	1.1
Reaction Time	1.0	1.8	3.4	1.4	1.7	1.1	1.8	-0.3	1.2
Type 2 Diabetes (T2D) (2018)	1.0	1.8	2.4	-1.5	-1.2	-1.5	-1.1	-1.1	-1.5
Multivitamins +/- minerals	1.0	1.2	2.3	-1.5	-1.0	-1.3	-0.7	0.6	-1.2
Medication for pain relief, constipation, heartburn	1.0	1.7	2.5	1.4	1.3	1.3	-0.7	1.6	1.4
Medication: Aspirin	1.0	1.3	2.0	-1.1	-1.3	-0.8	-0.7	-1.4	-1.3
Mood swings	1.0	1.9	4.5	-1.4	-2.1	-1.2	-0.8	1.1	-1.3
Wears glasses or contact lenses	1.0	1.1	1.4	1.1	1.1	1.1	1.2	-0.8	1.0
Basal cell carcinoma (self-reported)	1.0	1.2	1.7	-1.2	-1.3	-1.2	-0.9	-0.2	-1.3
Intelligence (Savage-Jansen 2018)	0.9	2.7	4.5	1.9	2.0	1.9	0.4	0.3	2.1
Alzheimer’s Disease (in mother)	0.9	1.0	1.9	1.4	0.7	1.1	0.3	1.1	1.2
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.5	0.8	0.9	1.2	0.5	-1.1	1.1
High blood pressure	0.9	2.6	4.0	-1.8	-1.8	-1.8	-1.3	-0.6	-2.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.1	1.0	1.5	1.3	-0.2	-0.5	1.4
Peak expiratory flow (PEF)	0.9	2.0	3.9	-2.0	-1.3	-1.8	0.2	0.7	-1.7
Headache pain in last month	0.9	1.6	3.2	-1.3	-1.8	-1.4	0.6	0.6	-1.4
Health satisfaction	0.9	1.2	2.4	-1.2	-1.5	-0.9	0.0	1.0	-1.3
Medication: Seretide 50 evohaler	0.9	1.1	2.1	-0.3	-0.9	-1.2	1.1	1.4	-0.9
Alcohol intake frequency.	0.9	2.1	4.0	-1.7	-2.0	-1.5	0.4	0.9	-1.6
Leg pain on walking	0.9	1.1	3.0	-1.0	-0.8	-1.0	-1.7	-0.3	-1.0
Illnesses of siblings: Diabetes	0.9	1.1	1.9	1.3	1.2	1.4	0.2	-0.4	1.2
Breast cancer (self-reported)	0.9	1.1	1.6	-1.0	-1.2	-1.1	-1.3	-0.9	-1.0
Osteoporosis (self-reported)	0.9	1.2	3.7	-0.7	-1.3	-0.4	-1.9	-0.6	-0.8
Smoking status: Current	0.9	1.5	3.3	-1.3	-1.3	-0.9	-1.8	-0.6	-1.1
Guilty feelings	0.9	1.4	2.3	-1.3	-1.1	-1.5	-1.0	0.7	-1.2
Financial situation satisfaction	0.9	1.1	4.0	-0.7	-0.5	-0.8	1.0	2.0	-0.6
Cardiovascular Disease	0.8	2.5	3.6	-1.9	-1.5	-1.9	-1.4	-0.2	-1.9
Medication: Co-codamol	0.8	0.9	2.0	-0.8	-1.4	-0.8	0.5	1.1	-0.9
Impedance of leg (right)	0.8	3.8	15.3	-1.6	-0.8	-1.0	-1.3	-3.9	-1.1
Time employed in main current job	0.8	0.9	2.1	-1.2	-0.2	-0.7	-1.4	-1.0	-0.7
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.3	1.5	0.9	1.2	0.9	0.7	1.3
Glaucoma (self-reported)	0.8	0.9	1.3	-1.1	-1.1	-1.2	-0.5	-0.7	-1.0
Medication: Ventolin 100micrograms inhaler	0.8	1.0	4.7	-0.4	-0.5	-0.6	0.8	2.2	-0.4
Knee pain experienced in last month	0.8	1.3	1.6	-1.2	-0.9	-1.1	-1.1	-1.3	-1.1
Hypertension (Self-reported)	0.8	2.2	3.2	-1.6	-1.7	-1.6	-1.2	-0.4	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	4.1	-1.0	0.2	-0.5	-0.1	-2.0	-0.3
Illnesses of father: Heart disease	0.8	1.1	1.7	-1.3	-1.0	-1.3	-0.7	0.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.7	-1.2	-0.0	-1.3	-0.9	-0.7	-0.9
Commuting to job workplace: Walk	0.8	0.9	1.5	0.8	1.1	0.9	0.6	-1.2	0.9
High cholesterol (Self-reported)	0.8	1.4	1.6	-1.3	-1.3	-1.2	-0.8	-1.2	-1.3
Ever smoked	0.8	1.4	3.0	-1.1	-0.6	-0.8	-1.6	-1.7	-0.8
Number of operations (self-reported)	0.8	1.2	3.0	-0.8	-1.5	-0.7	-0.2	1.7	-0.9
Prostate Cancer	0.7	1.0	2.2	-0.6	-0.9	-0.7	-1.5	1.2	-0.7
Coronary Artery Disease (CAD)	0.7	0.9	2.0	0.7	1.4	1.0	1.1	-0.2	0.8
Rheumatoid Arthritis	0.7	1.0	2.2	0.9	0.3	0.9	1.1	1.5	0.8
Lung FEV1/FVC ratio	0.7	3.6	4.3	-2.0	-2.0	-1.9	-2.1	-1.3	-2.1
Number of treatments/medications taken	0.7	1.3	2.3	-1.5	-1.3	-1.3	0.3	0.2	-1.4
Current tobacco smoking	0.7	1.2	1.9	-1.2	-1.4	-1.0	-1.1	-0.4	-1.2
Serious illness, injury or assault to yourself	0.7	0.9	2.1	-0.6	-1.4	-0.6	0.1	1.4	-0.7
Impedance of leg (left)	0.7	3.6	14.3	-1.5	-0.8	-1.0	-1.3	-3.8	-1.1
Hair/balding pattern: Pattern 3	0.7	1.1	2.4	0.9	0.8	1.1	0.6	1.6	1.0
Noisy workplace	0.7	0.8	3.6	0.0	-0.8	-0.3	0.6	1.9	-0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.5	1.5	1.4	1.5	-0.2	0.7	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.4	-0.8	-1.2	-1.2	0.9	0.1	-1.1
Tense / ‘highly strung’	0.7	1.2	2.1	-1.3	-1.2	-1.4	-0.3	0.2	-1.4
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.9	-1.2	-0.5	-0.7	1.4	-0.3	-1.0
Leg fat percentage (right)	0.7	2.5	4.2	-1.9	-1.6	-2.0	-0.7	-0.6	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.7	0.5	1.3	0.8	0.9	0.8	0.8
Irritability	0.7	1.2	6.2	-0.5	-0.4	-0.4	0.5	2.5	-0.5
Supplements: Calcium	0.7	0.8	2.6	0.0	-0.7	0.1	-1.2	1.6	-0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.3	-0.6	0.1	-0.3	-1.3	-1.5	-0.4
Number of incorrect matches in round	0.6	1.0	5.4	0.1	0.5	0.5	-0.3	-2.3	0.5
Hair/balding pattern: Pattern 2	0.6	0.7	3.8	-0.3	0.1	0.2	-0.6	-1.9	-0.1
Falls in the last year	0.6	0.8	1.8	-1.3	-0.9	-0.9	-0.6	0.3	-1.0
Mouth/teeth dental problems: Dentures	0.6	1.0	1.8	-1.1	-0.6	-0.7	1.0	-1.3	-0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	5.1	0.1	-0.4	0.1	-0.7	2.3	0.1
Leg fat percentage (left)	0.6	2.3	4.1	-1.9	-1.6	-2.0	-0.6	-0.2	-1.9
Impedance of whole body	0.6	3.1	9.3	-1.7	-1.2	-1.3	-1.3	-3.0	-1.3
Worry (Nagel 2018)	0.5	1.0	2.0	-0.9	-1.1	-0.9	-0.3	1.4	-1.0
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	0.8	0.5	0.9	0.4	1.2	1.0
Triglycerides	0.5	0.9	1.5	-1.1	-0.7	-1.1	-1.2	0.3	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.8	0.2	0.1	0.2	-0.8	-1.7	0.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.5	0.0	0.2	0.2	-1.6	-0.9	0.3
Hand grip strength (right)	0.5	1.5	2.1	-1.4	-1.0	-1.4	-1.4	-0.6	-1.2
Sitting height	0.5	3.8	7.6	2.1	2.8	2.0	0.1	1.1	2.4
Had menopause	0.5	0.7	2.8	0.6	0.5	0.5	0.3	-1.7	0.6
Impedance of arm (right)	0.5	2.2	3.9	-1.7	-1.3	-1.4	-1.2	-2.0	-1.2
Arm fat percentage (right)	0.5	2.1	3.6	-1.7	-1.5	-1.9	0.0	0.7	-1.7
Medication: Cholesterol lowering	0.5	0.8	2.0	-1.1	-0.1	-0.6	-1.4	-1.1	-0.7
Loud music exposure frequency	0.5	0.6	1.0	-1.0	-0.4	-0.8	-0.3	-0.9	-0.8
Medication: Amlodipine	0.5	0.7	1.1	-1.0	-1.0	-0.8	0.4	0.2	-1.1
Body fat percentage	0.5	1.9	3.4	-1.7	-1.4	-1.8	-0.4	0.1	-1.7
Leg fat mass (right)	0.5	1.8	3.4	-1.6	-1.2	-1.9	-0.2	0.4	-1.7
Number of full sisters	0.5	0.6	1.5	0.8	0.5	0.6	1.2	-1.0	0.4
Ever had bowel cancer screening	0.5	0.6	0.9	1.0	0.5	0.9	0.6	0.7	0.9
Eye problems/disorders: Cataract	0.5	0.5	1.1	-0.8	-0.6	-1.0	0.2	-0.2	-1.1
Medication: Gliclazide	0.5	0.6	1.2	-0.9	-0.8	-0.7	-1.1	0.4	-0.5
Number of self-reported non-cancer illnesses	0.5	0.8	1.3	-1.1	-0.9	-1.0	-0.9	0.4	-1.0
Medication: Blood pressure	0.5	1.0	2.4	-0.8	-1.6	-1.0	0.3	-0.5	-1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.0	-0.6	-0.7	-0.6	-1.4	-0.4	-0.5
Alcohol drinker status: Never	0.5	0.6	3.0	-0.2	-0.9	-0.1	-0.0	1.7	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.5	-0.6	-1.2	-0.7	-0.8	0.6	-0.9
Alcohol drinker status: Previous	0.5	0.6	1.0	0.7	0.3	0.8	1.0	-0.9	0.6
Leg fat mass (left)	0.5	1.8	3.4	-1.6	-1.2	-1.9	-0.2	0.6	-1.7
BMI	0.4	2.2	3.6	-1.4	-1.5	-1.7	-0.7	1.9	-1.4
Systolic Blood Pressure	0.4	1.8	3.2	-1.8	-1.4	-1.6	-0.7	-0.3	-1.6
Hand grip strength (left)	0.4	1.1	2.2	-1.4	-0.2	-0.9	-1.0	-1.5	-0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.9	-0.1	-1.0	-0.3	0.3	1.4	-0.3
Systolic blood pressure, automated reading	0.4	1.1	1.8	-1.1	-1.3	-1.2	-0.9	-0.3	-1.2
Severe depression (siblings)	0.4	0.5	2.7	0.3	0.0	0.1	0.3	1.6	0.2
Trunk fat percentage	0.4	1.8	3.4	-1.7	-1.3	-1.8	-0.3	0.2	-1.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.0	0.1	0.4	0.6	0.5	-1.4	0.2
Body mass index (BMI)	0.4	1.7	2.5	-1.3	-1.4	-1.6	0.0	1.4	-1.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	0.4	0.7	0.9	1.0	-0.6	0.5
Diabetes (self-reported)	0.4	0.6	0.9	-1.0	-0.8	-0.7	-0.9	-0.5	-0.8
Illnesses of siblings	0.4	0.6	1.1	0.8	0.5	1.0	0.0	0.6	1.1
Impedance of arm (left)	0.4	1.8	4.7	-1.3	-0.8	-1.0	-1.2	-2.2	-0.9
Medication: Paracetamol	0.4	0.7	3.9	0.2	0.6	0.2	2.0	-0.2	0.2
Whole body fat mass	0.4	1.5	2.8	-1.4	-1.1	-1.7	-0.0	0.8	-1.5
Comparative height size at age 10	0.4	2.0	4.2	1.4	2.0	1.7	-0.1	0.0	1.7
Family relationship satisfaction	0.4	0.4	1.4	0.4	0.3	0.4	0.7	1.2	0.6
Arm fat percentage (left)	0.4	1.7	3.1	-1.6	-1.3	-1.8	-0.1	0.7	-1.6
Diabetes diagnosed by doctor	0.4	0.7	1.5	-1.0	-0.6	-0.6	-1.2	-0.8	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.4	-0.2	-1.2	-0.4	-1.1	0.9	-0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	0.7	-0.8	-0.6	-0.8	-0.8	0.3	-0.7
Medication: Lisinopril	0.4	0.5	0.8	0.4	0.9	0.7	-0.8	-0.9	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.4	2.2	0.1	0.4	0.3	0.1	-1.5	0.1
Ever depressed for a whole week	0.4	0.4	1.0	0.6	0.6	1.0	0.3	0.5	0.8
HbA1C	0.3	0.3	0.8	0.0	0.9	0.4	-0.4	-0.5	0.5
HDL Cholesterol	0.3	0.5	0.9	0.9	0.6	0.9	0.8	0.0	0.7
Tanning	0.3	4.0	5.5	2.3	2.1	2.3	2.0	0.8	2.0
Hearing difficulty/problems: Yes	0.3	0.5	1.3	-0.5	-0.8	-0.1	0.8	-1.2	-0.6
Medication: Metformin	0.3	0.4	1.1	-0.5	-0.3	-0.3	-1.0	-1.0	-0.4
Leg fat-free mass (left)	0.3	1.4	6.8	0.4	0.6	-0.1	0.9	2.6	0.2
Relative age voice broke	0.3	0.5	1.0	-0.5	-1.0	-0.8	-0.7	0.2	-0.7
Leg predicted mass (left)	0.3	1.4	6.8	0.4	0.6	-0.1	0.9	2.6	0.2
Trunk fat mass	0.3	1.1	2.2	-1.2	-0.8	-1.5	0.0	0.7	-1.3
Nervous feelings	0.3	0.5	2.2	-0.2	-0.7	-0.4	0.3	1.5	-0.4
Had other major operations	0.3	0.4	1.4	0.6	-0.1	0.6	1.2	-0.0	0.4
Allergy	0.3	0.7	1.2	-1.1	-0.9	-0.7	-1.1	0.0	-0.7
Pain all over the body in last month	0.3	0.3	1.4	-0.1	0.2	0.2	0.6	-1.2	0.2
Trunk fat-free mass	0.3	1.6	4.6	1.1	1.2	0.6	1.1	2.1	0.9
Hip circumference	0.3	1.2	2.3	-1.1	-1.2	-1.4	-0.4	0.4	-1.5
Pulse rate	0.3	0.6	2.4	0.2	0.4	0.6	0.3	1.5	0.5
Arm fat mass (right)	0.3	1.3	2.2	-1.1	-1.0	-1.5	0.3	1.1	-1.3
Trunk predicted mass	0.3	1.7	4.8	1.1	1.2	0.6	1.1	2.2	0.9
Hair/balding pattern: Pattern 4	0.3	0.7	1.4	1.2	0.5	0.8	-0.1	0.9	0.9
Gout (self-reported)	0.3	0.4	0.7	-0.8	-0.1	-0.7	0.8	0.4	-0.7
Worry too long after embarrassment	0.3	0.5	1.1	-0.8	-0.4	-1.1	-0.7	0.0	-0.9
Wheeze or whistling in the chest in last year	0.3	0.6	2.4	0.8	0.1	0.5	1.6	0.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.6	0.1	0.5	0.5	-0.2	-1.3	0.3
Shortness of breath walking on level ground	0.3	0.4	2.0	0.4	0.5	0.1	1.4	0.4	0.1
Medication: Blood pressure	0.3	0.6	1.2	-0.9	-0.6	-0.7	-1.1	-0.4	-0.9
Heart disease (mother)	0.3	0.4	1.7	0.3	0.6	0.3	1.3	0.4	0.2
Arm predicted mass (right)	0.3	1.6	4.4	1.2	1.3	0.6	1.1	2.1	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.5	-0.4	-0.5	-0.4	-1.2	0.3	-0.3
Whole body fat-free mass	0.3	1.7	6.5	0.9	1.0	0.4	1.1	2.5	0.7
Leg fat-free mass (right)	0.3	1.6	8.1	0.5	0.6	-0.0	0.9	2.9	0.3
Loneliness, isolation	0.3	0.5	1.5	-0.4	-0.6	-0.7	-0.2	1.2	-0.4
Medication for cholesterol	0.3	0.4	1.4	0.2	0.7	0.5	-1.2	0.2	0.6
Mineral and other dietary supplements	0.3	0.4	0.9	0.5	1.0	0.5	0.7	-0.2	0.5
Whole body water mass	0.3	1.8	6.4	1.0	1.1	0.5	1.1	2.5	0.7
Leg predicted mass (right)	0.3	1.6	8.2	0.5	0.6	-0.0	0.9	2.9	0.3
Arm fat mass (left)	0.3	1.3	2.3	-1.2	-1.0	-1.5	0.1	1.1	-1.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	-0.6	-0.6	-0.7	0.1	0.2	-0.7
Commuting to job workplace: Public transport	0.3	0.3	1.0	0.5	-0.4	-0.1	1.0	0.8	-0.1
Medication: Paracetamol	0.3	0.5	2.4	-0.3	-0.0	-0.2	1.5	-0.4	-0.3
Arm fat-free mass (left)	0.3	1.6	6.2	1.0	0.9	0.3	1.2	2.5	0.6
Fractured/broken bones in last 5 years	0.3	0.4	1.0	-0.3	-1.0	-0.4	0.2	1.0	-0.4
Arm predicted mass (left)	0.3	1.3	5.5	0.8	0.7	0.1	1.1	2.3	0.4
Ulcerative Colitis (UC)	0.2	0.4	2.3	0.1	-0.0	-0.4	0.2	-1.5	-0.0
Breast Cancer	0.2	0.6	2.7	-0.5	-0.0	-0.4	-1.6	-0.5	-0.3
Bipolar Disorder (2011)	0.2	0.2	0.7	-0.2	-0.0	-0.3	0.2	0.8	-0.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.2	0.9	0.2	-0.5	0.2	0.5
Crohns Disease (2012)	0.2	0.4	1.0	-0.4	-1.0	-0.7	-0.0	0.5	-0.5
Fasting Glucose	0.2	0.2	0.5	-0.2	-0.1	-0.6	-0.5	-0.7	-0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.3	0.7	0.2	0.0	0.7	0.6
Ulcerative Colitis	0.2	0.3	1.6	-0.2	-0.0	-0.1	0.4	-1.3	-0.0
Blood Red Count	0.2	1.7	6.4	-0.5	-1.6	-0.5	0.2	2.5	-0.6
Allergy or Eczema	0.2	0.6	1.4	0.9	1.2	0.7	0.5	-0.5	0.7
Lung FVC	0.2	0.9	1.9	1.0	1.0	1.4	-0.0	0.5	1.3
Medication for hormone replacement therapy	0.2	0.3	1.3	0.1	-0.1	-0.2	1.1	0.6	-0.0
Maternal smoking around birth	0.2	0.2	0.3	-0.4	-0.5	-0.5	0.6	0.4	-0.4
Age when periods started (menarche)	0.2	0.4	1.5	0.8	-0.1	0.5	-0.1	1.2	0.5
Qualifications: CSEs or equivalent	0.2	0.2	0.5	-0.2	-0.5	-0.7	0.4	0.6	-0.4
Supplements: Glucosamine	0.2	0.2	0.8	0.5	0.1	0.3	-0.1	0.9	0.4
Medication: Levothyroxine sodium	0.2	0.3	0.4	-0.6	-0.3	-0.6	-0.6	-0.3	-0.6
Medication: Ramipril	0.2	0.3	1.0	0.2	-1.0	-0.2	-0.3	0.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.3	-1.1	-0.3	-0.9	-0.4	0.2	-0.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.3	0.1	0.4	0.6	0.7	0.3
Pulse wave reflection index	0.2	0.3	0.8	0.5	0.2	0.3	0.9	0.7	0.2
Blood clot in the leg (DVT)	0.2	0.3	0.9	-0.4	-0.9	-0.5	-0.2	0.5	-0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	1.5	0.4	1.0	0.7	0.2	1.2	0.8
Arm fat-free mass (right)	0.2	1.1	4.1	0.9	1.0	0.3	0.8	2.0	0.5
Pulse wave peak to peak time	0.2	0.2	0.5	-0.3	-0.1	-0.4	-0.5	-0.7	-0.3
Pulse rate, automated reading	0.2	0.6	1.3	0.0	0.7	0.7	-1.2	0.9	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	0.4	0.4	0.6	0.4	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.8	0.6	1.3	0.4	0.6	-0.1	0.7
Long-standing illness, disability or infirmity	0.2	0.3	1.1	0.4	0.5	0.5	-0.1	-1.1	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.5	-0.6	-0.6	-0.2	-0.0	-0.5
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.7	-0.5	-0.5	-0.5	-0.1	-0.5
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.5	0.2	-0.6	0.4	-0.5	-0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.4	-0.5	-0.8	0.3	-0.0	-0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	-0.2	0.0	-0.4	-0.7	0.8	-0.1
Basal metabolic rate	0.2	1.2	5.4	0.6	0.7	0.0	0.9	2.3	0.3
Pain experienced in last month	0.2	0.4	0.8	0.5	0.4	0.6	0.9	0.8	0.4
Bipolar Disorder (2018)	0.1	0.2	1.1	0.3	-0.3	0.3	-0.0	1.0	0.1
Alzheimer’s Disease (in father)	0.1	0.2	0.5	-0.1	0.6	0.0	0.7	-0.3	0.1
Irritable Bowel Disease (IBD)	0.1	0.2	1.2	0.2	-0.2	-0.1	0.3	-1.1	0.1
Lupus	0.1	0.2	0.7	0.1	0.4	0.5	-0.1	-0.9	0.3
Blood Eosinophil Count	0.1	1.1	2.4	1.1	1.6	1.1	0.6	-0.6	0.9
Height	0.1	1.8	4.9	1.2	2.2	0.9	1.4	0.3	1.3
Respiratory disease	0.1	0.2	0.7	0.5	0.1	0.2	0.3	0.9	0.2
Average weekly spirits intake	0.1	0.1	0.5	0.3	0.5	0.3	0.7	0.1	0.3
Relative age of first facial hair	0.1	0.2	0.9	-0.0	-0.4	-0.3	-0.5	0.9	-0.3
Vitamin and mineral supplements	0.1	0.1	0.2	-0.1	-0.4	-0.2	-0.5	-0.5	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.4	0.7	0.3	0.4	-0.3	0.3
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.0	0.4	0.3	0.3	0.4	0.5
Waist circumference	0.1	0.5	0.9	-0.9	-0.5	-0.9	0.3	0.3	-0.9
Weight	0.1	0.6	1.7	-0.6	-0.4	-1.0	0.2	1.3	-0.8
Worrier / anxious feelings	0.1	0.2	0.9	-0.1	-0.2	-0.1	-0.1	1.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	1.2	-0.0	0.5	0.1	0.1	1.1	0.2
Standing height	0.1	1.5	4.1	1.2	2.0	1.1	0.6	-0.0	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.2	-0.5	-0.3	-0.2	0.7	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	0.7	0.5	0.3	0.4	0.7	0.5
Exposure to tobacco smoke outside home	0.1	0.2	0.6	-0.1	-0.2	0.1	0.8	0.6	0.1
Medication: Allopurinol	0.1	0.2	0.4	-0.1	0.3	0.2	0.6	-0.6	0.0
Supplements: Vitamin C	0.1	0.1	0.3	0.2	-0.0	-0.2	0.1	0.6	-0.1
Friendships satisfaction	0.1	0.1	0.5	0.0	0.0	-0.0	0.3	0.7	0.1
Back pain experienced in last month	0.1	0.2	0.6	-0.0	-0.2	0.1	-0.8	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.5	-0.0	-0.4	-0.0	0.7	-0.2
Hearing aid user	0.1	0.1	0.2	0.3	0.2	0.2	0.5	0.3	0.0
Mother’s age at death	0.1	0.1	0.3	0.5	0.2	0.4	-0.3	0.4	0.3
Medication: Atorvastatin	0.1	0.2	0.4	-0.6	-0.1	-0.1	-0.6	0.4	-0.2
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.3	0.1	0.2	0.5	0.2	0.2
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.7	-0.3	-0.6	-0.4	-0.3	-0.4
Risk taking	0.1	0.2	0.3	0.3	0.5	0.3	0.5	-0.4	0.4
Crohns Disease (2017)	0.0	0.0	0.1	0.1	-0.3	-0.1	0.2	-0.3	-0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.2	-0.2	-0.2
Blood White Count	0.0	0.2	0.7	-0.0	-0.2	-0.5	-0.4	-0.8	-0.4
Heel T-Score	0.0	0.3	0.5	0.7	0.5	0.6	0.6	0.4	0.7
Waist Hip Ratio (WHR)	0.0	0.2	0.4	-0.2	0.6	0.3	0.2	-0.6	0.5
Hair Pigment	0.0	0.2	0.9	0.4	0.2	-0.3	0.9	-0.4	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.4	-0.0	-0.4	-0.2	-0.0	-0.4
Forced vital capacity (FVC)	0.0	0.2	0.6	-0.4	0.4	-0.2	-0.2	0.8	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.4	-0.2	0.2	-0.2	-0.2	-0.6	-0.3
Birth weight of first child	0.0	0.1	0.3	-0.6	-0.1	-0.1	-0.3	0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.2	0.2	-0.2	0.0	-0.2	0.4	0.1
Chest pain or discomfort	0.0	0.0	0.1	0.1	0.1	0.2	0.3	-0.3	0.0
Average weekly champagne plus white wine intake	0.0	0.1	0.2	-0.1	0.0	-0.2	-0.5	0.3	-0.2

Hub : Genes

AP2B1

Models

Trait associations