TWAS
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Neuroticism
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chr11:77,215,675-78,828,001
Best TWAS P=4.42e-09 · Best GWAS P=3.76e-08 conditioned to 0.0751
77.2M
77.4M
77.6M
77.8M
78M
78.2M
78.4M
78.6M
78.8M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
GAB2
0.05
0.00
blup
435
0.02
0.00080
-4.6
5.9
4.4e-09
-0.73
0.15
0.78
TRUE
1
GTEx
Testis
USP35
0.07
0.06
lasso
2
0.07
0.00064
-5.2
-5.2
1.7e-07
0.93
0.05
0.91
FALSE
3
The Cancer Genome Atlas
Stomach Adenocarcinoma
GAB2
0.04
0.04
blup
100
0.04
0.00140
-4.8
5.2
2.0e-07
-0.90
0.05
0.87
FALSE