Best TWAS P=4.03e-12 · Best GWAS P=6.05e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | MED19 | 0.11 | 0.04 | enet | 26 | 0.10 | 7.5e-06 | 6.6 | -5.9 | 3.3e-09 | -0.77 | 0.02 | 0.93 | FALSE |
| 2 | GTEx | Esophagus Mucosa | MED19 | 0.14 | 0.07 | lasso | 4 | 0.11 | 5.9e-08 | 3.1 | -5.7 | 1.5e-08 | -0.80 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | MED19 | 0.11 | 0.14 | lasso | 1 | 0.14 | 6.0e-07 | 6.6 | -6.6 | 3.2e-11 | -0.96 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Pancreas | MED19 | 0.10 | 0.08 | lasso | 3 | 0.02 | 5.0e-02 | 6.8 | -6.8 | 1.4e-11 | -0.98 | 0.02 | 0.89 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ZDHHC5 | 0.05 | 0.03 | lasso | 8 | 0.02 | 6.2e-03 | 6.5 | 6.7 | 2.8e-11 | 0.91 | 0.05 | 0.93 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | MED19 | 0.15 | 0.11 | lasso | 7 | 0.09 | 1.3e-07 | 6.8 | -6.8 | 1.1e-11 | -0.97 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Stomach | MED19 | 0.10 | 0.04 | lasso | 7 | 0.09 | 6.8e-05 | 6.5 | -5.9 | 3.1e-09 | -0.89 | 0.03 | 0.89 | FALSE |
| 8 | NTR | Blood | SERPING1 | 0.01 | 0.00 | blup | 399 | 0.00 | 2.9e-02 | -4.6 | 5.4 | 6.8e-08 | 0.69 | 0.08 | 0.76 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | ZDHHC5 | 0.05 | 0.02 | blup | 401 | 0.03 | 2.0e-04 | 6.8 | -6.7 | 1.5e-11 | -0.78 | 0.01 | 0.96 | FALSE |
| 10 | YFS | Blood | ZDHHC5 | 0.06 | 0.07 | enet | 20 | 0.07 | 1.2e-22 | 6.6 | 6.9 | 4.0e-12 | 0.96 | 0.01 | 0.99 | TRUE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MED19 | 0.05 | 0.03 | enet | 7 | 0.05 | 1.3e-10 | 6.5 | -5.5 | 3.0e-08 | -0.83 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMX2 | 0.01 | 0.01 | enet | 7 | 0.01 | 3.3e-03 | -4.4 | 5.2 | 1.8e-07 | 0.67 | 0.05 | 0.62 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMX2 | 0.07 | 0.06 | lasso | 1 | 0.05 | 5.0e-04 | 6.8 | 6.8 | 8.8e-12 | 0.98 | 0.00 | 0.92 | FALSE |
| 14 | The Cancer Genome Atlas | Esophageal Carcinoma | MED19 | 0.10 | 0.06 | lasso | 4 | 0.02 | 5.4e-02 | 6.9 | -6.9 | 6.1e-12 | -0.98 | 0.00 | 0.86 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MED19 | 0.03 | 0.01 | lasso | 2 | 0.02 | 1.9e-03 | 6.5 | -5.6 | 2.5e-08 | -0.80 | 0.01 | 0.64 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | MED19 | 0.05 | 0.02 | blup | 26 | 0.03 | 6.0e-05 | 6.8 | -5.7 | 9.1e-09 | -0.84 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED19 | 0.03 | 0.02 | lasso | 1 | 0.01 | 1.8e-02 | 6.6 | -6.6 | 3.2e-11 | -0.96 | 0.00 | 0.85 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMX2 | 0.03 | 0.02 | blup | 29 | 0.02 | 3.7e-03 | -4.4 | 5.5 | 4.1e-08 | 0.74 | 0.06 | 0.59 | FALSE |