[Hub]/) : Traits : Neuroticism : ← →

chr11:56,666,189-58,178,587

Best TWAS P=4.03e-12 · Best GWAS P=6.05e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	YFS	Blood	ZDHHC5	0.06	0.07	enet	20	0.07	1.2e-22	6.6	6.9	4.0e-12	0.96	0.01	0.99	TRUE
14	The Cancer Genome Atlas	Esophageal Carcinoma	MED19	0.10	0.06	lasso	4	0.02	5.4e-02	6.9	-6.9	6.1e-12	-0.98	0.00	0.86	FALSE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	TMX2	0.07	0.06	lasso	1	0.05	5.0e-04	6.8	6.8	8.8e-12	0.98	0.00	0.92	FALSE
6	GTEx	Skin Sun Exposed Lower leg	MED19	0.15	0.11	lasso	7	0.09	1.3e-07	6.8	-6.8	1.1e-11	-0.97	0.01	0.99	FALSE
4	GTEx	Pancreas	MED19	0.10	0.08	lasso	3	0.02	5.0e-02	6.8	-6.8	1.4e-11	-0.98	0.02	0.89	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	ZDHHC5	0.05	0.02	blup	401	0.03	2.0e-04	6.8	-6.7	1.5e-11	-0.78	0.01	0.96	FALSE
5	GTEx	Skin Sun Exposed Lower leg	ZDHHC5	0.05	0.03	lasso	8	0.02	6.2e-03	6.5	6.7	2.8e-11	0.91	0.05	0.93	FALSE
3	GTEx	Heart Atrial Appendage	MED19	0.11	0.14	lasso	1	0.14	6.0e-07	6.6	-6.6	3.2e-11	-0.96	0.02	0.98	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MED19	0.03	0.02	lasso	1	0.01	1.8e-02	6.6	-6.6	3.2e-11	-0.96	0.00	0.85	FALSE
7	GTEx	Stomach	MED19	0.10	0.04	lasso	7	0.09	6.8e-05	6.5	-5.9	3.1e-09	-0.89	0.03	0.89	FALSE
1	GTEx	Breast Mammary Tissue	MED19	0.11	0.04	enet	26	0.10	7.5e-06	6.6	-5.9	3.3e-09	-0.77	0.02	0.93	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	MED19	0.05	0.02	blup	26	0.03	6.0e-05	6.8	-5.7	9.1e-09	-0.84	0.01	0.99	FALSE
2	GTEx	Esophagus Mucosa	MED19	0.14	0.07	lasso	4	0.11	5.9e-08	3.1	-5.7	1.5e-08	-0.80	0.02	0.98	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MED19	0.03	0.01	lasso	2	0.02	1.9e-03	6.5	-5.6	2.5e-08	-0.80	0.01	0.64	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	MED19	0.05	0.03	enet	7	0.05	1.3e-10	6.5	-5.5	3.0e-08	-0.83	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMX2	0.03	0.02	blup	29	0.02	3.7e-03	-4.4	5.5	4.1e-08	0.74	0.06	0.59	FALSE
8	NTR	Blood	SERPING1	0.01	0.00	blup	399	0.00	2.9e-02	-4.6	5.4	6.8e-08	0.69	0.08	0.76	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMX2	0.01	0.01	enet	7	0.01	3.3e-03	-4.4	5.2	1.8e-07	0.67	0.05	0.62	FALSE