[Hub]/) : Traits : Neuroticism : ← →

chr11:112,135,760-113,969,669

Best TWAS P=2.27e-18 · Best GWAS P=2.54e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Caudate basal ganglia	TTC12	0.57	0.20	lasso	9	0.38	4.4e-12	3.1	5.5	5.0e-08	-0.09	0.97	0.00	FALSE
2	GTEx	Brain Caudate basal ganglia	RP11-159N11.4	0.32	0.07	lasso	7	0.14	9.7e-05	3.4	5.9	3.5e-09	-0.14	0.46	0.06	FALSE
3	GTEx	Brain Cortex	TTC12	0.48	0.39	lasso	5	0.43	3.2e-13	5.4	5.4	6.8e-08	-0.05	0.96	0.00	FALSE
4	GTEx	Brain Hypothalamus	RP11-159N11.4	0.44	0.06	lasso	19	0.03	7.5e-02	5.4	6.9	5.8e-12	-0.07	0.13	0.08	FALSE
5	GTEx	Breast Mammary Tissue	TTC12	0.46	0.30	lasso	7	0.40	8.1e-22	5.4	6.0	1.5e-09	-0.09	1.00	0.00	FALSE
6	GTEx	Breast Mammary Tissue (Female)	TTC12	0.46	0.22	lasso	10	0.34	6.2e-11	-6.4	5.5	4.9e-08	-0.06	0.97	0.00	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	TTC12	0.67	0.39	enet	34	0.54	4.6e-23	-5.8	5.6	1.6e-08	-0.07	1.00	0.00	FALSE
8	GTEx	Heart Left Ventricle	TTC12	0.39	0.24	enet	36	0.38	2.5e-21	7.6	7.0	2.0e-12	-0.17	1.00	0.00	FALSE
9	GTEx	Muscle Skeletal	TTC12	0.44	0.34	lasso	10	0.40	2.4e-41	-6.3	5.2	2.2e-07	-0.08	1.00	0.00	TRUE
10	GTEx	Skin Not Sun Exposed Suprapubic	TTC12	0.49	0.29	lasso	10	0.51	6.5e-32	5.4	5.6	2.2e-08	-0.09	1.00	0.00	FALSE
11	GTEx	Spleen	RP11-159N11.4	0.30	0.06	lasso	6	0.06	1.4e-02	7.3	6.3	3.0e-10	-0.07	0.14	0.05	FALSE
12	GTEx	Testis	TTC12	0.42	0.16	enet	33	0.38	7.7e-18	7.4	7.8	4.4e-15	-0.35	0.85	0.13	FALSE
13	GTEx	Uterus	NCAM1	0.41	-0.01	lasso	11	-0.01	5.9e-01	5.4	7.4	1.6e-13	-0.15	0.08	0.07	TRUE
14	METSIM	Adipose	ANKK1	0.16	0.11	enet	13	0.16	9.8e-23	-5.7	-8.6	1.1e-17	0.27	1.00	0.00	FALSE
15	YFS	Blood	ANKK1	0.04	0.03	lasso	3	0.03	2.9e-09	-6.1	-7.2	4.9e-13	0.23	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	TTC12	0.19	0.12	blup	48	0.15	1.1e-28	7.6	5.5	5.0e-08	-0.15	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ANKK1	0.04	0.02	blup	66	0.03	5.0e-04	7.3	8.5	2.2e-17	-0.25	0.22	0.18	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANKK1	0.04	0.03	blup	67	0.04	6.3e-05	7.2	-8.5	2.2e-17	0.36	0.55	0.18	TRUE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TTC12	0.49	0.30	enet	22	0.40	3.2e-48	7.6	5.3	1.1e-07	-0.07	0.01	0.99	TRUE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DRD2	0.13	0.05	blup	97	0.07	5.7e-05	4.2	5.9	4.1e-09	-0.65	0.05	0.86	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTC12	0.37	0.22	enet	5	0.22	1.1e-12	6.2	5.9	3.6e-09	-0.14	0.09	0.91	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTC12	0.33	0.28	blup	48	0.30	1.4e-34	7.6	5.9	4.5e-09	-0.14	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ANKK1	0.08	0.02	blup	66	0.04	5.6e-03	6.7	-7.1	1.6e-12	0.13	0.18	0.05	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	DRD2	0.06	0.07	lasso	2	0.07	6.6e-09	-8.7	8.7	2.3e-18	-0.89	0.06	0.94	TRUE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TTC12	0.25	0.12	blup	48	0.12	2.4e-08	6.2	5.8	6.6e-09	-0.21	0.12	0.88	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TTC12	0.36	0.30	lasso	3	0.29	6.0e-12	7.6	7.6	2.3e-14	-0.26	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTC12	0.21	0.20	lasso	4	0.22	1.2e-22	7.6	7.1	1.1e-12	-0.22	0.02	0.98	TRUE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	TTC12	0.25	0.10	enet	10	0.17	3.6e-12	6.2	5.3	9.3e-08	-0.16	0.02	0.98	FALSE
29	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TTC12	0.07	0.06	blup	48	0.04	1.6e-02	6.2	8.0	1.1e-15	-0.28	0.01	0.73	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	ANKK1	0.09	0.06	blup	67	0.07	9.9e-08	7.4	-5.8	7.2e-09	0.22	0.87	0.08	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	TTC12	0.73	0.41	enet	24	0.51	3.9e-57	6.2	5.4	6.3e-08	-0.04	0.84	0.16	FALSE