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chr9:126,927,285-129,422,783

Best TWAS P=6.05e-15 · Best GWAS P=1.15e-13 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PPP6C	0.03	0.01	bslmm	315	0.01	2.2e-02	-6.7	5.9	2.7e-09	0.04	0.10	0.19	TRUE
2	GTEx	Adipose Subcutaneous	PPP6C	0.06	0.10	lasso	3	0.07	3.2e-06	-6.7	7.0	2.7e-12	0.26	0.27	0.73	FALSE
3	GTEx	Adipose Subcutaneous	PBX3	0.17	0.08	lasso	6	0.10	2.4e-08	-5.3	-5.5	5.0e-08	-0.43	0.99	0.00	FALSE
4	GTEx	Artery Aorta	PRPS1P2	0.08	0.10	lasso	4	0.08	2.1e-05	5.5	-6.5	6.8e-11	-0.45	0.23	0.56	FALSE
5	GTEx	Artery Tibial	GAPVD1	0.11	0.16	enet	19	0.16	6.4e-13	6.4	7.4	1.7e-13	0.54	0.24	0.76	TRUE
6	GTEx	Artery Tibial	PBX3	0.11	0.07	lasso	2	0.06	8.1e-06	-5.8	-6.1	1.0e-09	-0.56	0.60	0.08	FALSE
7	GTEx	Artery Tibial	PRPS1P2	0.06	0.06	enet	6	0.05	9.2e-05	-6.9	-6.9	6.5e-12	-0.25	0.20	0.80	FALSE
8	GTEx	Brain Cerebellum	PRPS1P2	0.09	0.08	enet	16	0.04	2.8e-02	6.8	-7.6	2.1e-14	-0.43	0.14	0.42	FALSE
9	GTEx	Breast Mammary Tissue	PPP6C	0.11	0.08	enet	10	0.08	7.0e-05	-6.8	6.5	8.6e-11	0.16	0.20	0.72	FALSE
10	GTEx	Breast Mammary Tissue (Male)	PPP6C	0.12	0.03	enet	12	0.03	6.5e-02	-6.8	6.7	1.7e-11	0.21	0.06	0.20	FALSE
11	GTEx	Breast Mammary Tissue (Female)	PPP6C	0.14	0.04	lasso	4	0.04	3.1e-02	-6.8	7.4	9.8e-14	0.29	0.16	0.58	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	GOLGA1	0.13	0.00	enet	8	0.06	3.8e-03	-6.6	-6.6	4.2e-11	-0.28	0.19	0.56	FALSE
13	GTEx	Cells Transformed fibroblasts	PPP6C	0.07	0.05	enet	20	0.06	5.2e-05	-6.6	5.6	2.8e-08	0.13	0.26	0.73	FALSE
14	GTEx	Cells Transformed fibroblasts	MAPKAP1	0.04	0.03	lasso	3	0.02	6.5e-03	6.6	6.6	4.6e-11	0.86	0.09	0.83	TRUE
15	GTEx	Cells Transformed fibroblasts	PBX3	0.05	0.02	enet	7	0.00	1.4e-01	6.3	-7.2	6.9e-13	-0.86	0.14	0.67	FALSE
16	GTEx	Cells Transformed fibroblasts	PRPS1P2	0.09	0.11	enet	8	0.13	9.6e-10	-6.6	-6.4	1.3e-10	-0.21	0.29	0.71	FALSE
17	GTEx	Colon Sigmoid	PBX3	0.23	0.22	lasso	3	0.16	1.9e-06	-5.5	-5.3	1.0e-07	-0.49	0.91	0.03	FALSE
18	GTEx	Colon Transverse	PRPS1P2	0.11	0.10	lasso	1	0.08	1.8e-04	-6.5	-6.5	6.2e-11	-0.28	0.22	0.68	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	PBX3	0.21	0.19	lasso	5	0.14	1.0e-05	-5.5	-5.8	5.3e-09	-0.51	0.35	0.58	FALSE
20	GTEx	Esophagus Mucosa	PPP6C	0.07	0.07	enet	21	0.08	7.1e-06	-6.3	6.5	6.7e-11	0.22	0.24	0.76	FALSE
21	GTEx	Esophagus Mucosa	PRPS1P2	0.07	0.08	lasso	3	0.07	1.5e-05	-6.8	-6.7	1.8e-11	-0.26	0.21	0.76	FALSE
22	GTEx	Esophagus Muscularis	PBX3	0.12	0.08	lasso	7	0.09	4.2e-06	-5.8	-6.2	5.0e-10	-0.58	0.81	0.18	FALSE
23	GTEx	Heart Atrial Appendage	PBX3	0.10	0.08	lasso	6	0.04	9.0e-03	-5.5	-6.4	1.9e-10	-0.51	0.28	0.13	FALSE
24	GTEx	Heart Left Ventricle	PBX3	0.21	0.22	lasso	4	0.21	3.3e-11	-5.3	-5.3	9.1e-08	-0.40	1.00	0.00	FALSE
25	GTEx	Lung	PRPS1P2	0.05	0.05	lasso	2	0.04	3.4e-04	-5.4	-6.4	1.5e-10	-0.16	0.24	0.65	FALSE
26	GTEx	Muscle Skeletal	PPP6C	0.03	0.03	enet	6	0.01	3.0e-02	-6.4	7.0	2.8e-12	0.26	0.21	0.62	FALSE
27	GTEx	Muscle Skeletal	GAPVD1	0.13	0.10	lasso	3	0.09	4.7e-09	6.7	-6.8	8.1e-12	-0.54	0.19	0.81	FALSE
28	GTEx	Nerve Tibial	PPP6C	0.12	0.14	enet	18	0.16	3.6e-11	-6.7	6.4	1.4e-10	0.12	0.25	0.75	FALSE
29	GTEx	Nerve Tibial	GAPVD1	0.17	0.08	lasso	10	0.10	9.3e-08	-6.3	7.5	7.6e-14	0.40	0.20	0.80	FALSE
30	GTEx	Nerve Tibial	PBX3	0.08	0.03	enet	21	0.03	2.3e-03	-5.3	-5.1	3.1e-07	-0.35	0.32	0.12	FALSE
31	GTEx	Nerve Tibial	PRPS1P2	0.11	0.11	enet	9	0.10	1.4e-07	-6.8	-7.2	5.0e-13	-0.22	0.26	0.74	FALSE
32	GTEx	Ovary	PRPS1P2	0.14	0.14	lasso	2	0.05	2.9e-02	-6.7	-7.2	8.3e-13	-0.25	0.12	0.39	FALSE
33	GTEx	Pancreas	PRPS1P2	0.16	0.13	lasso	6	0.12	8.7e-06	-6.9	-6.8	8.4e-12	-0.26	0.20	0.79	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	PPP6C	0.08	0.06	lasso	4	0.05	7.8e-04	-6.8	6.9	6.8e-12	0.15	0.23	0.51	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	PBX3	0.12	0.13	lasso	2	0.13	1.8e-07	-5.8	-5.7	1.5e-08	-0.45	0.96	0.01	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	PRPS1P2	0.09	0.01	lasso	5	0.02	4.6e-02	4.5	-5.2	2.2e-07	-0.27	0.19	0.26	FALSE
37	GTEx	Skin Sun Exposed Lower leg	PPP6C	0.11	0.10	lasso	5	0.09	9.1e-08	-6.7	6.0	2.6e-09	0.06	0.33	0.67	FALSE
38	GTEx	Skin Sun Exposed Lower leg	RABEPK	0.07	0.05	lasso	4	0.05	6.3e-05	-6.7	6.7	2.1e-11	0.15	0.33	0.64	FALSE
39	GTEx	Skin Sun Exposed Lower leg	GAPVD1	0.04	0.01	lasso	4	0.01	3.8e-02	-6.8	7.8	6.1e-15	0.39	0.21	0.69	TRUE
40	GTEx	Spleen	MAPKAP1	0.30	0.12	lasso	6	0.04	2.7e-02	5.9	5.2	2.5e-07	0.66	0.13	0.50	FALSE
41	GTEx	Spleen	PRPS1P2	0.18	0.02	lasso	4	0.04	3.9e-02	-6.7	-7.8	8.0e-15	-0.29	0.09	0.25	FALSE
42	GTEx	Testis	PBX3	0.19	0.22	lasso	3	0.20	4.7e-09	-5.0	-5.5	4.6e-08	-0.46	0.96	0.02	FALSE
43	GTEx	Thyroid	ARPC5L	0.18	0.12	enet	17	0.16	1.5e-12	-3.8	-5.7	1.1e-08	-0.28	0.99	0.01	TRUE
44	GTEx	Thyroid	GAPVD1	0.05	0.05	enet	13	0.01	6.6e-02	6.8	7.2	4.7e-13	0.52	0.17	0.81	FALSE
45	GTEx	Thyroid	PBX3	0.07	0.00	lasso	6	0.01	4.7e-02	-4.9	-6.4	2.0e-10	-0.29	0.33	0.24	FALSE
46	GTEx	Thyroid	PRPS1P2	0.08	0.09	enet	18	0.07	4.0e-06	-6.9	-7.4	1.4e-13	-0.27	0.22	0.77	FALSE
47	GTEx	Whole Blood	RABEPK	0.10	0.11	enet	14	0.09	7.2e-09	-6.7	6.3	2.2e-10	0.22	0.32	0.68	FALSE
48	METSIM	Adipose	ARPC5L	0.02	0.01	blup	270	0.02	1.5e-03	-6.7	-5.3	1.1e-07	-0.15	0.16	0.66	FALSE
49	NTR	Blood	MAPKAP1	0.03	0.01	blup	441	0.02	2.3e-07	6.5	7.0	2.9e-12	0.77	0.20	0.80	TRUE
50	NTR	Blood	PPP6C	0.03	0.03	lasso	6	0.03	5.4e-11	-6.8	7.0	1.8e-12	0.23	0.26	0.74	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	PPP6C	0.11	0.19	lasso	5	0.20	8.6e-26	-6.7	7.0	2.2e-12	0.21	0.31	0.69	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	SCAI	0.02	0.00	bslmm	316	0.00	3.3e-01	6.1	6.5	9.3e-11	0.59	0.04	0.22	FALSE
53	YFS	Blood	RABEPK	0.12	0.21	bslmm	317	0.22	2.4e-71	-6.6	7.2	7.9e-13	0.32	0.58	0.42	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPP6C	0.03	0.03	lasso	5	0.03	7.3e-07	-6.7	7.0	3.2e-12	0.19	0.04	0.96	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	RABEPK	0.02	0.02	lasso	2	0.02	1.4e-04	-6.7	6.6	3.0e-11	0.14	0.03	0.87	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPP6C	0.07	0.08	lasso	3	0.09	5.4e-10	-6.8	7.1	1.3e-12	0.24	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PPP6C	0.05	0.06	lasso	3	0.05	1.1e-03	-6.8	7.2	8.5e-13	0.19	0.03	0.78	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPP6C	0.02	0.02	lasso	2	0.01	1.5e-02	-6.6	6.5	9.3e-11	0.27	0.02	0.62	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCAI	0.02	0.02	blup	94	0.01	2.1e-02	-3.8	5.5	4.8e-08	0.21	0.15	0.24	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	PPP6C	0.02	0.02	lasso	4	0.02	7.6e-04	-6.9	6.8	1.1e-11	0.26	0.03	0.96	FALSE
61	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PPP6C	0.17	0.06	enet	5	0.09	2.0e-04	-6.7	6.7	2.1e-11	0.15	0.02	0.45	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	GAPVD1	0.02	0.04	enet	4	0.01	9.8e-03	6.6	-5.8	7.5e-09	-0.55	0.05	0.76	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	PBX3	0.03	0.03	blup	65	0.04	5.4e-05	-5.3	-5.7	1.3e-08	-0.47	0.42	0.54	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPP6C	0.06	0.08	lasso	7	0.07	1.8e-07	-6.8	6.4	1.3e-10	0.24	0.03	0.97	FALSE
65	The Cancer Genome Atlas	Stomach Adenocarcinoma	PPP6C	0.05	0.04	blup	46	0.03	3.8e-03	-6.8	6.5	1.0e-10	0.26	0.02	0.96	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	PPP6C	0.08	0.13	enet	9	0.13	5.5e-13	-6.8	7.1	1.2e-12	0.26	0.03	0.97	FALSE