[Hub]/) : Traits : Smoking Status :

chr9:126,927,285-129,422,783

Best TWAS P=6.05e-15 · Best GWAS P=1.15e-13 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PPP6C 0.03 0.01 bslmm 315 0.01 2.2e-02 -6.7 5.9 2.7e-09 0.04 0.10 0.19 TRUE
2 GTEx Adipose Subcutaneous PPP6C 0.06 0.10 lasso 3 0.07 3.2e-06 -6.7 7.0 2.7e-12 0.26 0.27 0.73 FALSE
3 GTEx Adipose Subcutaneous PBX3 0.17 0.08 lasso 6 0.10 2.4e-08 -5.3 -5.5 5.0e-08 -0.43 0.99 0.00 FALSE
4 GTEx Artery Aorta PRPS1P2 0.08 0.10 lasso 4 0.08 2.1e-05 5.5 -6.5 6.8e-11 -0.45 0.23 0.56 FALSE
5 GTEx Artery Tibial GAPVD1 0.11 0.16 enet 19 0.16 6.4e-13 6.4 7.4 1.7e-13 0.54 0.24 0.76 TRUE
6 GTEx Artery Tibial PBX3 0.11 0.07 lasso 2 0.06 8.1e-06 -5.8 -6.1 1.0e-09 -0.56 0.60 0.08 FALSE
7 GTEx Artery Tibial PRPS1P2 0.06 0.06 enet 6 0.05 9.2e-05 -6.9 -6.9 6.5e-12 -0.25 0.20 0.80 FALSE
8 GTEx Brain Cerebellum PRPS1P2 0.09 0.08 enet 16 0.04 2.8e-02 6.8 -7.6 2.1e-14 -0.43 0.14 0.42 FALSE
9 GTEx Breast Mammary Tissue PPP6C 0.11 0.08 enet 10 0.08 7.0e-05 -6.8 6.5 8.6e-11 0.16 0.20 0.72 FALSE
10 GTEx Breast Mammary Tissue (Male) PPP6C 0.12 0.03 enet 12 0.03 6.5e-02 -6.8 6.7 1.7e-11 0.21 0.06 0.20 FALSE
11 GTEx Breast Mammary Tissue (Female) PPP6C 0.14 0.04 lasso 4 0.04 3.1e-02 -6.8 7.4 9.8e-14 0.29 0.16 0.58 FALSE
12 GTEx Cells EBV-transformed lymphocytes GOLGA1 0.13 0.00 enet 8 0.06 3.8e-03 -6.6 -6.6 4.2e-11 -0.28 0.19 0.56 FALSE
13 GTEx Cells Transformed fibroblasts PPP6C 0.07 0.05 enet 20 0.06 5.2e-05 -6.6 5.6 2.8e-08 0.13 0.26 0.73 FALSE
14 GTEx Cells Transformed fibroblasts MAPKAP1 0.04 0.03 lasso 3 0.02 6.5e-03 6.6 6.6 4.6e-11 0.86 0.09 0.83 TRUE
15 GTEx Cells Transformed fibroblasts PBX3 0.05 0.02 enet 7 0.00 1.4e-01 6.3 -7.2 6.9e-13 -0.86 0.14 0.67 FALSE
16 GTEx Cells Transformed fibroblasts PRPS1P2 0.09 0.11 enet 8 0.13 9.6e-10 -6.6 -6.4 1.3e-10 -0.21 0.29 0.71 FALSE
17 GTEx Colon Sigmoid PBX3 0.23 0.22 lasso 3 0.16 1.9e-06 -5.5 -5.3 1.0e-07 -0.49 0.91 0.03 FALSE
18 GTEx Colon Transverse PRPS1P2 0.11 0.10 lasso 1 0.08 1.8e-04 -6.5 -6.5 6.2e-11 -0.28 0.22 0.68 FALSE
19 GTEx Esophagus Gastroesophageal Junction PBX3 0.21 0.19 lasso 5 0.14 1.0e-05 -5.5 -5.8 5.3e-09 -0.51 0.35 0.58 FALSE
20 GTEx Esophagus Mucosa PPP6C 0.07 0.07 enet 21 0.08 7.1e-06 -6.3 6.5 6.7e-11 0.22 0.24 0.76 FALSE
21 GTEx Esophagus Mucosa PRPS1P2 0.07 0.08 lasso 3 0.07 1.5e-05 -6.8 -6.7 1.8e-11 -0.26 0.21 0.76 FALSE
22 GTEx Esophagus Muscularis PBX3 0.12 0.08 lasso 7 0.09 4.2e-06 -5.8 -6.2 5.0e-10 -0.58 0.81 0.18 FALSE
23 GTEx Heart Atrial Appendage PBX3 0.10 0.08 lasso 6 0.04 9.0e-03 -5.5 -6.4 1.9e-10 -0.51 0.28 0.13 FALSE
24 GTEx Heart Left Ventricle PBX3 0.21 0.22 lasso 4 0.21 3.3e-11 -5.3 -5.3 9.1e-08 -0.40 1.00 0.00 FALSE
25 GTEx Lung PRPS1P2 0.05 0.05 lasso 2 0.04 3.4e-04 -5.4 -6.4 1.5e-10 -0.16 0.24 0.65 FALSE
26 GTEx Muscle Skeletal PPP6C 0.03 0.03 enet 6 0.01 3.0e-02 -6.4 7.0 2.8e-12 0.26 0.21 0.62 FALSE
27 GTEx Muscle Skeletal GAPVD1 0.13 0.10 lasso 3 0.09 4.7e-09 6.7 -6.8 8.1e-12 -0.54 0.19 0.81 FALSE
28 GTEx Nerve Tibial PPP6C 0.12 0.14 enet 18 0.16 3.6e-11 -6.7 6.4 1.4e-10 0.12 0.25 0.75 FALSE
29 GTEx Nerve Tibial GAPVD1 0.17 0.08 lasso 10 0.10 9.3e-08 -6.3 7.5 7.6e-14 0.40 0.20 0.80 FALSE
30 GTEx Nerve Tibial PBX3 0.08 0.03 enet 21 0.03 2.3e-03 -5.3 -5.1 3.1e-07 -0.35 0.32 0.12 FALSE
31 GTEx Nerve Tibial PRPS1P2 0.11 0.11 enet 9 0.10 1.4e-07 -6.8 -7.2 5.0e-13 -0.22 0.26 0.74 FALSE
32 GTEx Ovary PRPS1P2 0.14 0.14 lasso 2 0.05 2.9e-02 -6.7 -7.2 8.3e-13 -0.25 0.12 0.39 FALSE
33 GTEx Pancreas PRPS1P2 0.16 0.13 lasso 6 0.12 8.7e-06 -6.9 -6.8 8.4e-12 -0.26 0.20 0.79 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic PPP6C 0.08 0.06 lasso 4 0.05 7.8e-04 -6.8 6.9 6.8e-12 0.15 0.23 0.51 FALSE
35 GTEx Skin Not Sun Exposed Suprapubic PBX3 0.12 0.13 lasso 2 0.13 1.8e-07 -5.8 -5.7 1.5e-08 -0.45 0.96 0.01 FALSE
36 GTEx Skin Not Sun Exposed Suprapubic PRPS1P2 0.09 0.01 lasso 5 0.02 4.6e-02 4.5 -5.2 2.2e-07 -0.27 0.19 0.26 FALSE
37 GTEx Skin Sun Exposed Lower leg PPP6C 0.11 0.10 lasso 5 0.09 9.1e-08 -6.7 6.0 2.6e-09 0.06 0.33 0.67 FALSE
38 GTEx Skin Sun Exposed Lower leg RABEPK 0.07 0.05 lasso 4 0.05 6.3e-05 -6.7 6.7 2.1e-11 0.15 0.33 0.64 FALSE
39 GTEx Skin Sun Exposed Lower leg GAPVD1 0.04 0.01 lasso 4 0.01 3.8e-02 -6.8 7.8 6.1e-15 0.39 0.21 0.69 TRUE
40 GTEx Spleen MAPKAP1 0.30 0.12 lasso 6 0.04 2.7e-02 5.9 5.2 2.5e-07 0.66 0.13 0.50 FALSE
41 GTEx Spleen PRPS1P2 0.18 0.02 lasso 4 0.04 3.9e-02 -6.7 -7.8 8.0e-15 -0.29 0.09 0.25 FALSE
42 GTEx Testis PBX3 0.19 0.22 lasso 3 0.20 4.7e-09 -5.0 -5.5 4.6e-08 -0.46 0.96 0.02 FALSE
43 GTEx Thyroid ARPC5L 0.18 0.12 enet 17 0.16 1.5e-12 -3.8 -5.7 1.1e-08 -0.28 0.99 0.01 TRUE
44 GTEx Thyroid GAPVD1 0.05 0.05 enet 13 0.01 6.6e-02 6.8 7.2 4.7e-13 0.52 0.17 0.81 FALSE
45 GTEx Thyroid PBX3 0.07 0.00 lasso 6 0.01 4.7e-02 -4.9 -6.4 2.0e-10 -0.29 0.33 0.24 FALSE
46 GTEx Thyroid PRPS1P2 0.08 0.09 enet 18 0.07 4.0e-06 -6.9 -7.4 1.4e-13 -0.27 0.22 0.77 FALSE
47 GTEx Whole Blood RABEPK 0.10 0.11 enet 14 0.09 7.2e-09 -6.7 6.3 2.2e-10 0.22 0.32 0.68 FALSE
48 METSIM Adipose ARPC5L 0.02 0.01 blup 270 0.02 1.5e-03 -6.7 -5.3 1.1e-07 -0.15 0.16 0.66 FALSE
49 NTR Blood MAPKAP1 0.03 0.01 blup 441 0.02 2.3e-07 6.5 7.0 2.9e-12 0.77 0.20 0.80 TRUE
50 NTR Blood PPP6C 0.03 0.03 lasso 6 0.03 5.4e-11 -6.8 7.0 1.8e-12 0.23 0.26 0.74 FALSE
51 ROSMAP Brain Pre-frontal Cortex PPP6C 0.11 0.19 lasso 5 0.20 8.6e-26 -6.7 7.0 2.2e-12 0.21 0.31 0.69 FALSE
52 ROSMAP Brain Pre-frontal Cortex SCAI 0.02 0.00 bslmm 316 0.00 3.3e-01 6.1 6.5 9.3e-11 0.59 0.04 0.22 FALSE
53 YFS Blood RABEPK 0.12 0.21 bslmm 317 0.22 2.4e-71 -6.6 7.2 7.9e-13 0.32 0.58 0.42 FALSE
54 The Cancer Genome Atlas Breast Invasive Carcinoma PPP6C 0.03 0.03 lasso 5 0.03 7.3e-07 -6.7 7.0 3.2e-12 0.19 0.04 0.96 FALSE
55 The Cancer Genome Atlas Breast Invasive Carcinoma RABEPK 0.02 0.02 lasso 2 0.02 1.4e-04 -6.7 6.6 3.0e-11 0.14 0.03 0.87 FALSE
56 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPP6C 0.07 0.08 lasso 3 0.09 5.4e-10 -6.8 7.1 1.3e-12 0.24 0.02 0.98 FALSE
57 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PPP6C 0.05 0.06 lasso 3 0.05 1.1e-03 -6.8 7.2 8.5e-13 0.19 0.03 0.78 FALSE
58 The Cancer Genome Atlas Brain Lower Grade Glioma PPP6C 0.02 0.02 lasso 2 0.01 1.5e-02 -6.6 6.5 9.3e-11 0.27 0.02 0.62 FALSE
59 The Cancer Genome Atlas Brain Lower Grade Glioma SCAI 0.02 0.02 blup 94 0.01 2.1e-02 -3.8 5.5 4.8e-08 0.21 0.15 0.24 FALSE
60 The Cancer Genome Atlas Lung Adenocarcinoma PPP6C 0.02 0.02 lasso 4 0.02 7.6e-04 -6.9 6.8 1.1e-11 0.26 0.03 0.96 FALSE
61 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PPP6C 0.17 0.06 enet 5 0.09 2.0e-04 -6.7 6.7 2.1e-11 0.15 0.02 0.45 FALSE
62 The Cancer Genome Atlas Prostate Adenocarcinoma GAPVD1 0.02 0.04 enet 4 0.01 9.8e-03 6.6 -5.8 7.5e-09 -0.55 0.05 0.76 FALSE
63 The Cancer Genome Atlas Prostate Adenocarcinoma PBX3 0.03 0.03 blup 65 0.04 5.4e-05 -5.3 -5.7 1.3e-08 -0.47 0.42 0.54 FALSE
64 The Cancer Genome Atlas Prostate Adenocarcinoma PPP6C 0.06 0.08 lasso 7 0.07 1.8e-07 -6.8 6.4 1.3e-10 0.24 0.03 0.97 FALSE
65 The Cancer Genome Atlas Stomach Adenocarcinoma PPP6C 0.05 0.04 blup 46 0.03 3.8e-03 -6.8 6.5 1.0e-10 0.26 0.02 0.96 FALSE
66 The Cancer Genome Atlas Thyroid Carcinoma PPP6C 0.08 0.13 enet 9 0.13 5.5e-13 -6.8 7.1 1.2e-12 0.26 0.03 0.97 FALSE