TWAS hub - SSSCA1-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.066	0.0309	0.0049	0.053	NA	0.035	NA	0.036	5.3e-05	NA	0.0009	NA	0.00080
2	GTEx	Cells EBV-transformed lymphocytes	0.198	0.0860	0.0048	0.184	NA	0.035	NA	0.090	1.3e-06	NA	0.0260	NA	0.00073

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Type 2 Diabetes (T2D) (2018)	17.2	32.2	32.5	5.7	5.7
Diabetes diagnosed by doctor	14.9	24.5	25.0	5.0	4.9
Medication: Metformin	13.9	19.6	20.7	4.6	4.3
Heel T-Score	13.2	104.9	110.2	10.5	10.0
Diabetes (self-reported)	12.2	18.8	19.2	4.3	4.4
Diabetes (mother)	11.9	15.2	16.2	3.8	4.0
Heel bone mineral density (BMD) T-score, automated (left)	10.8	24.4	25.8	5.1	4.8
Type 2 Diabetes (T2D) (2012)	8.4	9.7	11.1	2.9	3.3
Heel bone mineral density (BMD) T-score, automated (right)	7.5	17.1	18.7	4.3	3.9
Mouth/teeth dental problems	7.5	11.4	12.9	-3.2	-3.6
Blood Platelet Count	6.7	77.6	87.2	-8.2	-9.3
Asthma	6.6	13.1	15.2	3.9	3.3
Mouth/teeth dental problems: Loose teeth	6.5	7.7	9.2	2.5	3.0
Hearing aid user	6.5	7.4	7.9	-2.6	-2.8
Shortness of breath walking on level ground	6.4	7.6	8.1	2.7	2.9
Age when periods started (menarche)	6.1	14.7	15.6	-3.7	-4.0
Medication: Gliclazide	6.1	6.8	7.3	2.7	2.5
Birth weight	6.0	12.9	14.1	3.8	3.4
Pain experienced in last month	6.0	10.0	10.1	-3.2	-3.2
Pulse rate, automated reading	5.9	19.0	19.6	-4.3	-4.4
Impedance of arm (left)	5.8	26.9	27.9	-5.1	-5.3
Ever had prostate specific antigen (PSA) test	5.8	6.7	7.7	-2.8	-2.4
Gout (self-reported)	5.3	7.2	8.1	-2.5	-2.8
Serious illness, injury or assault to yourself	5.0	6.1	6.7	2.6	2.3
Impedance of arm (right)	4.8	22.6	23.6	-4.6	-4.9
Family relationship satisfaction	4.8	5.9	6.9	2.6	2.2
Mouth/teeth dental problems: Dentures	4.7	7.9	9.4	2.5	3.1
Mouth/teeth dental problems: Bleeding gums	4.6	6.0	6.2	2.5	2.4
Asthma (self-reported)	4.6	9.2	11.1	3.3	2.7
Ever depressed for a whole week	4.5	5.6	6.4	2.5	2.2
Diabetes (father)	4.4	5.4	5.7	2.4	2.3
Medication: Allopurinol	4.2	5.6	6.1	-2.3	-2.5
Pack years of smoking	4.2	6.1	6.2	2.5	2.5
Rheumatoid Arthritis	4.0	5.5	6.2	-2.5	-2.2
Wheeze or whistling in the chest in last year	3.9	6.9	8.0	2.8	2.4
Leg fat percentage (right)	3.8	13.8	15.6	4.0	3.5
Chest pain or discomfort	3.8	5.5	6.6	2.6	2.1
Pack years adult smoking proportion	3.7	5.6	5.7	2.4	2.3
Loneliness, isolation	3.7	5.1	5.3	2.2	2.3
Leg fat percentage (left)	3.7	13.3	14.9	3.9	3.4
Hair/balding pattern: Pattern 3	3.6	5.4	5.8	2.4	2.2
Eye problems/disorders: Glaucoma	3.6	4.3	5.0	-2.2	-1.9
Fasting Glucose	3.5	4.2	4.5	2.0	2.1
Medication: Atenolol	3.5	4.4	4.7	-2.0	-2.2
Hair/balding pattern: Pattern 2	3.5	4.5	5.2	-1.9	-2.3
Chronic bronchitis/emphysema (mother)	3.5	4.0	4.4	-2.1	-1.9
Myopia	3.5	5.1	6.0	-2.0	-2.4
Birth weight of first child	3.4	6.2	6.3	2.5	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.3	4.4	4.9	2.2	2.0
Medication: Ventolin 100micrograms inhaler	3.3	4.3	6.1	2.5	1.6
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	4.3	2.1	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.9	6.6	2.6	1.8
Systolic blood pressure, automated reading	3.1	9.0	11.0	2.7	3.3
Body mass index (BMI)	3.1	13.2	13.9	3.7	3.5
Ever unenthusiastic/disinterested for a whole week	3.1	3.8	4.3	2.1	1.8
Leg fat mass (right)	3.1	11.9	13.2	3.6	3.2
Waist Hip Ratio (WHR)	3.0	13.4	13.8	3.7	3.6
Reaction Time	2.9	5.5	5.6	2.4	2.3
HDL Cholesterol	2.9	4.9	6.1	-1.9	-2.5
Sensitivity / hurt feelings	2.9	5.0	5.4	-2.3	-2.1
Angina	2.9	3.8	4.0	-2.0	-1.9
Comparative body size at age 10	2.9	7.9	8.6	2.7	2.9
Leg pain on walking	2.9	3.6	3.7	1.9	1.9
Fractured/broken bones in last 5 years	2.9	3.7	3.8	-1.9	-1.9
Leg fat mass (left)	2.9	11.3	12.4	3.5	3.2
Mean Putamen Volume	2.8	3.2	3.5	1.7	1.9
Current tobacco smoking	2.8	4.6	4.8	2.2	2.1
Irritable Bowel Disease (IBD)	2.7	6.4	7.4	-2.3	-2.7
Breastfed as a baby	2.7	3.3	4.0	-1.6	-2.0
Illness, injury, bereavement, stress in last 2 years	2.7	3.3	3.4	-1.8	-1.8
Smoking status: Current	2.7	4.3	4.6	2.1	2.0
Respiratory disease	2.6	5.9	6.4	2.5	2.3
Friendships satisfaction	2.6	3.2	3.4	1.7	1.9
Supplements: Calcium	2.6	2.8	3.1	-1.8	-1.6
Waist circumference	2.5	9.2	9.7	3.1	3.0
Health satisfaction	2.5	3.2	3.5	1.9	1.7
Neck or shoulder pain in last month	2.5	3.5	3.8	1.9	1.8
Angina (self-reported)	2.5	3.3	3.4	-1.9	-1.8
Overall health rating	2.5	5.3	5.9	2.4	2.2
BMI	2.4	14.1	15.5	3.9	3.5
Impedance of whole body	2.4	12.3	13.1	-3.4	-3.6
Crohns Disease (2017)	2.3	5.0	5.7	-2.1	-2.4
Lung cancer (father)	2.3	2.7	2.8	-1.6	-1.7
Eye problems/disorders: None of the above	2.3	2.7	3.1	1.8	1.5
Illnesses of father: None of the above (group 1)	2.3	2.9	3.7	-1.9	-1.4
Supplements: Fish oil (including cod liver oil)	2.3	3.0	3.5	-1.6	-1.9
Ulcerative Colitis (UC)	2.2	4.1	4.5	-1.9	-2.1
Systolic Blood Pressure	2.2	11.2	14.9	2.7	3.9
Father’s age at death	2.2	3.0	3.3	-1.6	-1.8
Mean time to correctly identify matches	2.2	4.2	4.5	2.1	2.0
Medication: Atorvastatin	2.2	2.7	2.7	-1.6	-1.7
Number of incorrect matches in round	2.1	3.6	4.2	-1.7	-2.1
Arm fat mass (right)	2.1	8.5	9.3	3.0	2.8
Body Mass Index (BMI) (2010)	2.0	2.8	3.2	1.8	1.6
Blood Eosinophil Count	2.0	15.6	17.6	-3.7	-4.2
Average weekly fortified wine intake	2.0	2.4	2.8	-1.7	-1.4
Pulse rate	2.0	3.4	3.7	-1.8	-1.9
Mood swings	2.0	3.6	3.7	1.9	1.8
Stomach or abdominal pain in last month	1.9	2.4	2.6	1.6	1.5
Medication: Ibuprofen	1.9	2.3	2.8	-1.3	-1.7
Arm fat-free mass (left)	1.9	9.8	10.1	3.1	3.2
Financial difficulties in last 2 years	1.8	2.4	2.8	1.4	1.7
Pulse wave Arterial Stiffness index	1.8	2.1	2.4	-1.6	-1.3
Exposure to tobacco smoke outside home	1.8	2.5	3.0	1.7	1.4
Knee pain experienced in last month	1.8	2.8	2.9	1.6	1.7
Arm fat mass (left)	1.8	7.4	8.1	2.8	2.6
Arm predicted mass (left)	1.8	9.2	9.2	3.0	3.0
Depressed Affect (Nagel 2018)	1.7	3.6	3.6	1.9	1.9
Nervous feelings	1.7	3.2	3.4	-1.7	-1.8
Breast cancer (self-reported)	1.7	2.0	2.2	-1.5	-1.4
Commuting to job workplace: Cycle	1.7	2.0	2.6	-1.6	-1.2
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	2.4	-1.2	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	1.9	1.4	1.4
Glaucoma (self-reported)	1.6	1.9	2.5	-1.6	-1.2
High blood pressure (siblings)	1.6	2.4	2.5	1.5	1.6
Arm fat-free mass (right)	1.6	8.1	8.2	2.8	2.9
Average weekly red wine intake	1.6	2.4	2.6	1.6	1.5
Mineral and other dietary supplements	1.6	2.1	2.5	1.3	1.6
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	2.2	-1.3	-1.5
Falls in the last year	1.5	2.0	2.2	-1.5	-1.3
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.3	-1.3	-1.5
Migraine (self-reported)	1.5	1.9	2.1	1.3	1.5
Comparative height size at age 10	1.5	8.4	8.8	-2.8	-3.0
Illnesses of siblings: Diabetes	1.5	1.8	2.7	1.6	1.0
Schizophrenia (2018)	1.4	2.8	2.9	1.7	1.6
Major Depression (MDD)	1.4	1.7	1.8	1.3	1.3
Lupus	1.4	2.2	2.6	1.6	1.3
Ulcerative Colitis	1.4	2.1	2.7	-1.6	-1.2
Blood White Count	1.4	10.3	10.9	-3.3	-3.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	2.5	1.6	1.3
Weight	1.4	6.7	7.1	2.7	2.5
Arm fat percentage (right)	1.4	5.4	6.2	2.5	2.1
Qualifications: College or University degree	1.4	4.5	5.7	-2.4	-1.8
Commuting to job workplace: Public transport	1.4	1.7	1.7	1.3	1.3
Age at first live birth	1.3	2.2	2.6	-1.6	-1.4
Whole body fat mass	1.3	5.6	6.4	2.5	2.2
Arm predicted mass (right)	1.3	6.8	6.9	2.6	2.6
Age at last live birth	1.3	1.9	2.0	-1.4	-1.4
Long-standing illness, disability or infirmity	1.3	2.0	2.4	1.3	1.5
Schizophrenia vs Biploar Disorder	1.2	1.5	1.9	1.1	1.4
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	2.2	1.2	1.5
Illnesses of father: Heart disease	1.2	1.7	2.0	1.4	1.2
Arm fat percentage (left)	1.2	4.8	5.6	2.4	2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.3	-1.1	-1.1
LDL Cholesterol	1.1	1.7	1.7	1.3	1.3
Lung FVC	1.1	5.3	5.8	2.2	2.4
Body fat percentage	1.1	4.5	5.5	2.3	1.9
Pulse wave peak to peak time	1.1	1.3	1.5	1.2	1.0
Average weekly champagne plus white wine intake	1.1	1.5	2.0	-1.0	-1.4
Miserableness	1.1	1.8	2.1	1.5	1.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	1.9	-1.4	-1.0
Triglycerides	1.0	1.6	2.0	1.1	1.4
Illnesses of siblings	1.0	1.4	2.2	-1.5	-0.8
Exposure to tobacco smoke at home	1.0	1.1	1.1	1.1	1.0
Medication: Paracetamol	1.0	1.6	2.1	-1.0	-1.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.5	-0.9	-1.2
Financial situation satisfaction	1.0	1.3	1.5	1.2	1.0
Irritability	1.0	1.7	2.1	1.4	1.1
Cholesterol lowering medication	1.0	1.5	2.2	0.9	1.5
Length of working week for main job	0.9	1.0	1.1	0.9	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.2	1.0	1.1
Medication for cholesterol	0.9	1.4	1.9	-1.0	-1.4
Osteoarthritis (self-reported)	0.9	1.2	1.3	-1.2	-1.0
Coronary Artery Disease (CAD)	0.8	1.0	2.0	-1.4	0.0
Trunk fat-free mass	0.8	4.5	4.5	2.1	2.1
Worrier / anxious feelings	0.8	1.5	1.7	-1.2	-1.3
Trunk predicted mass	0.8	4.5	4.6	2.1	2.1
Forced vital capacity (FVC), Best measure	0.8	2.8	3.8	1.4	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.2	0.8	1.1
Osteoporosis (self-reported)	0.8	1.0	1.1	-0.9	-1.1
Wears glasses or contact lenses	0.8	0.9	1.1	-0.9	-1.0
Ever taken oral contraceptive pill	0.8	0.9	0.9	0.9	1.0
Basal metabolic rate	0.8	4.2	4.2	2.1	2.0
Crohns Disease (2012)	0.7	1.2	1.7	-0.8	-1.3
HbA1C	0.7	0.8	1.0	0.7	1.0
High blood pressure (mother)	0.7	1.0	1.1	1.0	1.0
Medication: Simvastatin	0.7	1.0	1.0	1.0	1.0
Number of full brothers	0.7	0.9	1.5	1.2	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.6	-0.5	-1.2
Medication: Omeprazole	0.7	0.8	0.9	0.9	0.9
Average weekly spirits intake	0.6	0.7	0.8	0.8	0.9
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.1	1.0	0.8
Ever had hysterectomy (womb removed)	0.6	0.7	0.7	-0.8	-0.8
Impedance of leg (right)	0.6	3.0	3.7	-1.5	-1.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	0.7	0.9	0.7
Impedance of leg (left)	0.6	2.7	3.3	-1.4	-1.8
Trunk fat mass	0.6	2.5	3.0	1.7	1.4
Headache pain in last month	0.6	1.0	1.2	1.1	0.9
Whole body fat-free mass	0.6	3.3	3.4	1.8	1.8
Medication: Aspirin	0.6	0.7	0.8	-0.9	-0.8
Whole body water mass	0.6	3.5	3.5	1.9	1.9
Risk taking	0.6	0.9	1.3	1.1	0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	1.4	1.2	1.0
Depression (Nagel 2018)	0.5	0.8	1.1	1.0	0.7
Height	0.5	9.6	11.2	-2.8	-3.3
Chronotype (morning person)	0.5	1.2	1.4	-1.2	-1.0
Had menopause	0.5	0.6	0.6	-0.8	-0.7
Qualifications: None of the above	0.5	1.1	1.3	-0.9	-1.2
Happiness	0.5	0.6	0.7	0.8	0.7
Depression (self-reported)	0.5	0.5	1.0	1.0	0.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.0	1.0	0.5
Blood clot in the leg (DVT)	0.5	0.7	0.9	-1.0	-0.6
Alcohol drinker status: Never	0.5	0.6	0.9	-0.9	-0.6
Ovarian Cancer	0.4	0.5	0.6	0.8	0.6
Primary Biliary Cirrhosis	0.4	0.5	0.6	0.8	0.6
Schizophrenia (2014)	0.4	0.9	1.2	0.8	1.1
Cardiovascular Disease	0.4	1.4	2.2	0.8	1.5
Lung FEV1/FVC ratio	0.4	1.8	1.9	-1.4	-1.3
Hair Pigment	0.4	12.5	13.2	-3.4	-3.6
Fed-up feelings	0.4	0.6	1.0	0.6	1.0
High blood pressure	0.4	1.1	1.6	0.8	1.2
Multivitamins +/- minerals	0.4	0.5	0.6	-0.6	-0.8
Sitting height	0.4	2.7	3.0	1.7	1.6
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.8	0.6
Allergy	0.4	0.9	1.3	-1.1	-0.7
Number of full sisters	0.4	0.4	0.5	-0.6	-0.7
Commuting to job workplace: Walk	0.4	0.5	0.5	-0.7	-0.7
Medication: Paracetamol	0.4	0.6	0.9	-0.5	-1.0
Heart disease (siblings)	0.4	0.5	1.0	1.0	0.2
Neuroticism (Nagel 2018)	0.3	0.7	0.7	0.8	0.9
Alzheimer’s Disease (in mother)	0.3	0.3	0.4	-0.5	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.1	-1.0	-0.6
Breast Cancer	0.3	0.7	1.1	-0.6	-1.1
Prostate Cancer	0.3	0.4	0.5	0.6	0.7
Relative age of first facial hair	0.3	0.5	0.8	-0.9	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.5	0.6	0.7
Supplements: Zinc	0.3	0.3	0.4	-0.5	-0.6
Trunk fat percentage	0.3	1.1	1.5	1.2	0.8
Had other major operations	0.3	0.4	0.6	-0.5	-0.8
Pain all over the body in last month	0.3	0.3	0.4	0.4	0.7
Illnesses of mother	0.3	0.4	0.6	-0.8	-0.5
Standing height	0.3	3.3	3.4	-1.9	-1.8
Medication: Amlodipine	0.3	0.4	0.5	-0.6	-0.7
Heart disease (mother)	0.3	0.4	0.5	-0.7	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.3	-0.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.5	-0.7	-0.6
Average weekly beer plus cider intake	0.3	0.4	0.7	0.8	0.4
Age started oral contraceptive pill	0.3	0.4	0.6	-0.8	-0.3
Alcohol drinker status: Previous	0.3	0.4	0.7	-0.8	-0.2
Worry (Nagel 2018)	0.2	0.3	0.5	-0.7	-0.5
Alzheimer’s Disease (including proxy)	0.2	0.2	0.3	0.5	0.4
Blood Red Count	0.2	1.5	2.3	0.8	1.5
Allergy or Eczema	0.2	0.6	1.1	1.0	0.5
Hand grip strength (left)	0.2	0.5	0.5	-0.7	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.3	-0.5	-0.5
Leg fat-free mass (left)	0.2	1.2	1.2	1.1	1.1
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.8	0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.3	0.7
Medication: Levothyroxine sodium	0.2	0.4	0.5	0.4	0.7
Leg predicted mass (left)	0.2	1.2	1.2	1.1	1.1
Forced vital capacity (FVC)	0.2	0.6	1.0	0.5	1.0
Heart attack	0.2	0.2	0.4	-0.6	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	0.6	-0.8	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.5	0.6	0.7
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.4	0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.3	-0.6
Alcohol intake frequency.	0.2	0.4	0.8	-0.9	-0.0
Suffer from ‘nerves’	0.2	0.3	0.3	-0.5	-0.6
Leg fat-free mass (right)	0.2	1.0	1.1	1.0	1.1
Leg predicted mass (right)	0.2	1.0	1.1	1.0	1.1
Medication: Blood pressure	0.2	0.4	0.6	0.4	0.7
Illnesses of father: High blood pressure	0.2	0.3	0.3	-0.6	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.7	0.0
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.2	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.5	0.5	0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.1	-0.2	-0.3
Neuroticism (2016)	0.1	0.1	0.1	0.3	0.3
Smoking Status	0.1	0.3	0.4	0.4	0.7
Hypothyroidism (self reported)	0.1	0.1	0.3	0.2	0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.2	0.4	0.4
Medication: Co-codamol	0.1	0.1	0.2	0.3	0.4
Relative age voice broke	0.1	0.1	0.2	-0.5	0.0
Qualifications: CSEs or equivalent	0.1	0.2	0.3	0.2	0.6
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.6	0.0
Past tobacco smoking	0.1	0.2	0.2	-0.3	-0.5
Medication: Ramipril	0.1	0.1	0.2	0.1	0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.0	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.5	-0.1
Number of live births	0.1	0.2	0.2	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	-0.7	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.5	0.5
Medication: Cholesterol lowering	0.1	0.1	0.2	0.4	0.3
Tense / ‘highly strung’	0.1	0.1	0.1	0.3	0.3
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.5	-0.3
Number of children fathered	0.1	0.1	0.1	-0.3	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	0.1	0.4
Medication: Blood pressure	0.1	0.1	0.1	-0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.2	-0.4	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.2	0.4	0.4
Medication: Aspirin	0.1	0.1	0.2	-0.5	-0.3
Supplements: Vitamin C	0.1	0.1	0.2	-0.4	-0.3
Hypertension (Self-reported)	0.1	0.2	0.4	0.2	0.7
Smoking status: Previous	0.1	0.1	0.2	0.1	0.4
Eye problems/disorders: Cataract	0.1	0.2	0.3	-0.5	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.2	-0.5	-0.4
Back pain experienced in last month	0.1	0.1	0.3	0.1	0.5
Guilty feelings	0.1	0.1	0.2	-0.5	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.4	0.2
Medication: Bendroflumethiazide	0.1	0.1	0.1	0.3	0.2
Ever smoked	0.1	0.1	0.2	0.3	0.5
Number of operations (self-reported)	0.1	0.1	0.1	-0.2	-0.4
Unable to work because of sickness or disability	0.1	0.2	0.3	-0.5	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	-0.1	-0.7
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.3	-0.5
Age at First Birth	0.0	0.0	0.0	-0.1	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.2	0.0
Neuroticism	0.0	0.1	0.1	0.3	0.3
Tanning	0.0	0.1	0.2	0.5	0.2
Number of treatments/medications taken	0.0	0.1	0.2	0.4	-0.0
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.2	-0.1
Vitamin and mineral supplements	0.0	0.1	0.1	0.2	0.3
Severe depression (siblings)	0.0	0.1	0.1	-0.2	-0.3
Hand grip strength (right)	0.0	0.1	0.1	-0.0	0.3
Maternal smoking around birth	0.0	0.1	0.1	-0.3	-0.1
Taking other prescription medications	0.0	0.0	0.0	0.1	0.1
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	0.0
Alcohol usually taken with meals	0.0	0.0	0.1	0.0	0.3
Hearing difficulty/problems with background noise	0.0	0.0	0.0	0.1	-0.1
Fluid intelligence score	0.0	0.1	0.2	-0.4	-0.0
Neuroticism score	0.0	0.0	0.0	0.1	0.1
Hip circumference	0.0	0.0	0.0	-0.2	-0.2
Time employed in main current job	0.0	0.0	0.0	0.2	0.2
Noisy workplace	0.0	0.0	0.1	0.3	-0.1
Medication: Lansoprazole	0.0	0.0	0.0	0.1	-0.0
Prospective memory result	0.0	0.0	0.1	0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.0	-0.2	0.2
Pulse wave reflection index	0.0	0.0	0.0	-0.1	0.2
Loud music exposure frequency	0.0	0.0	0.1	0.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	-0.3	-0.2
Worry too long after embarrassment	0.0	0.0	0.1	0.1	0.3
Had major operations	0.0	0.1	0.1	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.0	-0.1	-0.0
Ever had bowel cancer screening	0.0	0.0	0.0	0.1	-0.2
Qualifications: nursing, teaching	0.0	0.0	0.0	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.1	0.3
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	0.4	-0.0
Mother’s age at death	0.0	0.0	0.0	-0.0	-0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.2	0.2
High cholesterol (Self-reported)	0.0	0.1	0.1	0.1	0.3
Medication: Lisinopril	0.0	0.0	0.0	0.2	0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.1	-0.3	0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.1	0.0

Hub : Genes

SSSCA1-AS1

Models

Trait associations