TWAS hub - SCN4A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0419	0.0191	3.6e-06	0.011	0.034	0.027	NA	0.026	0.002	1.4e-07	2.2e-06	NA	3.9e-06
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0504	0.0210	1.8e-05	0.006	0.040	0.030	NA	0.026	0.058	2.2e-05	2.5e-04	NA	5.6e-04
3	TCGA	Thyroid Carcinoma	0.0440	0.0250	7.5e-03	0.010	0.019	0.016	NA	0.014	0.035	5.7e-03	8.8e-03	NA	1.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative height size at age 10	19.5	107.5	185.0	-13.6	-8.8	-7.8
Standing height	17.9	178.0	327.6	-18.1	-11.2	-9.0
Forced vital capacity (FVC), Best measure	16.8	61.5	104.0	-10.2	-7.2	-5.4
Sitting height	16.7	118.6	210.2	-14.5	-10.2	-6.5
Height	16.3	313.5	590.5	-24.3	-14.1	-12.3
Trunk predicted mass	15.8	90.1	174.2	-13.2	-8.8	-4.3
Trunk fat-free mass	15.4	88.6	171.6	-13.1	-8.7	-4.2
Forced expiratory volume in 1-second (FEV1), Best measure	14.9	47.5	76.7	-8.8	-6.7	-4.6
Forced vital capacity (FVC)	14.7	56.5	98.6	-9.9	-7.1	-4.5
Whole body fat-free mass	12.9	73.8	144.0	-12.0	-8.0	-3.8
Whole body water mass	12.9	73.8	144.0	-12.0	-8.0	-3.8
Forced expiratory volume in 1-second (FEV1)	12.5	42.1	68.6	-8.3	-6.6	-3.7
Arm fat-free mass (right)	12.3	63.3	121.0	-11.0	-7.6	-3.4
Arm predicted mass (right)	11.5	59.0	114.5	-10.7	-7.3	-3.1
Arm fat-free mass (left)	11.3	57.2	108.2	-10.4	-7.2	-3.3
Arm predicted mass (left)	10.9	55.2	104.0	-10.2	-7.2	-3.2
Basal metabolic rate	10.6	58.7	114.5	-10.7	-7.0	-3.4
Peak expiratory flow (PEF)	10.1	23.4	36.5	-5.3	-6.0	-2.3
Leg fat-free mass (right)	9.6	51.1	102.0	-10.1	-6.6	-2.8
Leg predicted mass (right)	9.6	51.1	102.0	-10.1	-6.6	-2.8
Forced expiratory volume in 1-second (FEV1), predicted	9.5	19.8	32.6	-5.7	-3.7	-3.6
Leg predicted mass (left)	8.9	47.2	93.1	-9.7	-6.3	-3.0
Leg fat-free mass (left)	8.8	46.6	92.4	-9.6	-6.2	-2.9
Medication: Paracetamol	6.2	9.6	14.8	3.8	3.3	1.9
Hand grip strength (right)	4.8	13.1	27.3	-5.2	-3.2	-1.2
Relative age of first facial hair	4.1	8.5	14.3	3.3	3.8	0.7
Waist Hip Ratio (WHR)	4.0	18.1	31.5	5.6	4.4	1.8
Weight	3.8	18.6	36.1	-6.0	-3.7	-2.5
Noisy workplace	3.8	4.6	6.9	2.6	1.7	2.0
Medication: Paracetamol	3.6	6.0	10.3	3.2	2.4	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	7.3	2.7	2.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.4	11.4	-3.4	-2.7	-1.9
Medication: Blood pressure	3.4	6.0	10.5	3.2	2.5	1.2
Hair/balding pattern: Pattern 4	3.2	7.7	14.1	-3.8	-2.0	-2.3
Leg fat percentage (right)	3.2	11.6	22.2	4.7	3.5	0.7
Rheumatoid Arthritis	3.1	4.2	6.4	1.9	2.5	1.6
Commuting to job workplace: Walk	3.1	3.3	5.2	-2.3	-1.6	-1.5
Osteoarthritis (self-reported)	3.1	4.0	5.4	2.3	1.8	1.9
Leg fat percentage (left)	3.1	11.4	22.0	4.7	3.3	1.0
Hand grip strength (left)	3.0	7.9	16.6	-4.1	-2.6	-0.4
Medication: Metformin	3.0	4.3	5.6	2.4	2.3	1.4
Type 2 Diabetes (T2D) (2012)	2.7	3.1	4.6	2.1	1.4	1.7
Lung FVC	2.7	13.7	23.4	-4.8	-3.3	-2.6
Prostate Cancer	2.6	3.7	7.1	2.7	1.9	0.7
Lupus	2.6	4.0	5.9	2.4	2.4	0.5
Breast cancer (self-reported)	2.5	3.0	3.6	-1.6	-1.9	-1.7
Primary Biliary Cirrhosis	2.4	3.4	4.6	2.1	1.0	2.1
Chronotype (morning person)	2.4	5.5	7.9	-2.2	-1.9	-2.8
Alcohol usually taken with meals	2.4	3.9	5.2	-2.3	-2.0	-1.6
Medication: Allopurinol	2.4	3.2	4.3	-2.1	-1.8	-1.4
Relative age voice broke	2.3	3.5	5.1	1.9	2.3	1.3
Had other major operations	2.3	2.8	4.4	-1.7	-2.1	-1.0
Arm fat percentage (right)	2.3	9.2	16.0	4.0	3.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	4.1	2.0	1.7	1.2
Arm fat percentage (left)	2.3	9.2	16.0	4.0	3.1	1.4
Systolic blood pressure, automated reading	2.2	6.4	7.7	2.8	2.3	2.5
Neck or shoulder pain in last month	2.2	3.2	5.5	1.8	2.3	1.0
Wears glasses or contact lenses	2.2	2.5	3.5	1.7	1.9	1.1
Body fat percentage	2.1	8.4	15.6	4.0	3.0	0.5
Medication: Omeprazole	2.1	2.5	4.2	2.0	1.3	1.3
Impedance of leg (right)	2.0	9.7	17.1	4.1	3.1	-1.5
Impedance of leg (left)	2.0	9.9	18.2	4.3	3.2	-1.2
Alcohol drinker status: Never	2.0	2.4	4.0	1.7	2.0	0.6
Neuroticism (Nagel 2018)	1.9	4.4	8.4	2.0	2.9	0.9
Hearing difficulty/problems: Yes	1.9	2.9	4.3	2.1	1.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	3.9	2.0	0.5	1.5
Medication: Blood pressure	1.9	3.5	8.7	-1.1	-3.0	-0.8
Impedance of whole body	1.9	9.7	17.1	4.1	3.2	-1.4
Current tobacco smoking	1.8	3.0	4.5	2.1	2.1	0.2
Serious illness, injury or assault to yourself	1.8	2.2	3.3	1.6	1.8	0.9
Impedance of arm (right)	1.8	8.2	11.8	3.4	3.3	-1.5
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	5.8	2.4	1.7	0.6
Headache pain in last month	1.8	3.1	4.2	1.4	2.1	1.7
Number of children fathered	1.8	2.0	2.6	-1.1	-1.6	-1.5
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.0	-1.4	-0.7	-2.0
Medication: Gliclazide	1.8	2.0	3.5	1.9	1.6	0.2
Smoking status: Current	1.8	2.8	4.5	2.0	2.1	-0.0
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	4.2	2.0	1.0	1.2
Depressed Affect (Nagel 2018)	1.7	3.5	4.8	2.1	2.2	1.1
Neuroticism	1.7	4.1	8.0	2.0	2.8	0.6
Mouth/teeth dental problems	1.7	2.6	3.6	-1.9	-1.5	-1.4
Worry too long after embarrassment	1.7	2.8	7.9	0.7	2.8	0.1
Medication for pain relief, constipation, heartburn	1.7	2.9	5.1	-2.3	-1.8	-0.4
Age at last live birth	1.7	2.5	4.8	-1.3	-1.0	-2.2
Alzheimer’s Disease (in mother)	1.6	1.9	2.9	1.6	1.7	0.3
Diabetes (father)	1.6	2.0	3.0	1.7	1.2	1.1
Trunk fat percentage	1.6	6.5	11.6	3.4	2.8	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	3.4	1.8	1.9	0.8
Had menopause	1.6	2.0	3.3	-1.4	-0.9	-1.8
Hip circumference	1.6	7.0	13.3	-3.6	-2.3	-1.6
Impedance of arm (left)	1.6	7.5	11.4	3.4	3.1	-1.2
High blood pressure (siblings)	1.6	2.4	4.9	-1.4	-2.2	-0.5
Wheeze or whistling in the chest in last year	1.6	2.9	5.4	2.3	1.6	0.8
Medication: Co-codamol	1.5	1.7	2.6	1.6	1.5	0.7
Mean time to correctly identify matches	1.5	2.8	6.1	0.7	2.5	-1.3
Supplements: Vitamin C	1.5	1.7	1.9	-1.4	-1.2	-1.4
Mineral and other dietary supplements	1.5	2.1	2.7	1.6	1.3	1.4
Irritability	1.5	2.5	5.5	1.1	2.3	-0.8
Blood Red Count	1.4	13.8	29.9	-3.4	-5.5	-0.0
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	4.5	-2.1	-0.9	-1.2
Average weekly red wine intake	1.4	2.0	3.8	-1.9	-1.3	-0.8
Tinnitus: Yes, now most or all of the time	1.4	1.6	2.7	-1.6	-1.4	-0.6
Smoking Status	1.3	3.2	5.0	2.2	2.2	0.2
Type 2 Diabetes (T2D) (2018)	1.3	2.5	3.9	1.8	0.5	2.0
Medication: Ramipril	1.3	1.7	3.5	1.9	1.0	0.6
Blood clot in the leg (DVT)	1.3	1.7	2.4	-1.1	-1.2	-1.5
Diabetes diagnosed by doctor	1.3	2.2	3.2	1.8	1.3	1.3
Body Mass Index (BMI) (2010)	1.2	1.6	1.9	1.2	-1.4	1.3
Respiratory disease	1.2	2.8	6.1	2.5	0.1	1.5
Severe depression (siblings)	1.2	1.4	3.6	0.7	1.9	-0.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.4	1.6	1.2	0.6
Smoking status: Previous	1.2	1.7	2.7	-1.1	-1.1	-1.6
Guilty feelings	1.2	1.8	5.3	0.3	2.3	0.3
Depression (Nagel 2018)	1.1	1.7	2.5	1.6	1.5	0.7
Coronary Artery Disease (CAD)	1.1	1.3	1.7	1.2	1.3	0.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	1.9	-1.4	-1.0	-1.1
Tense / ‘highly strung’	1.1	1.8	2.3	1.4	1.5	1.0
Pulse wave reflection index	1.1	1.3	3.0	-0.5	-0.8	-1.7
Medication: Seretide 50 evohaler	1.1	1.3	1.9	1.4	0.6	1.2
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.8	1.0	1.7	0.2
Unable to work because of sickness or disability	1.1	1.4	1.8	1.3	0.9	1.4
Number of treatments/medications taken	1.0	1.8	3.8	1.9	1.2	-0.0
Sensitivity / hurt feelings	1.0	1.7	3.9	0.3	1.1	-2.0
Medication for cholesterol	1.0	1.5	4.2	0.3	2.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.6	1.3	1.3	0.5
Supplements: Fish oil (including cod liver oil)	1.0	1.4	2.7	-1.6	-0.8	-0.9
Ever depressed for a whole week	1.0	1.2	1.9	-1.4	-0.5	-1.2
Commuting to job workplace: Cycle	1.0	1.2	2.7	-1.6	-0.6	-0.8
Bipolar Disorder (2018)	0.9	1.4	2.1	-1.1	-0.9	-1.4
Schizophrenia (2018)	0.9	1.8	3.4	1.1	1.9	0.8
Maternal smoking around birth	0.9	1.3	2.1	-1.1	-1.5	-0.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.0	0.6	1.0	1.4
Number of live births	0.9	1.3	3.6	-0.6	-0.1	-1.9
Asthma	0.9	1.8	3.6	1.9	0.1	1.3
Medication: Cholesterol lowering	0.9	1.3	2.5	1.6	0.9	0.8
Back pain experienced in last month	0.9	1.3	3.2	0.6	-0.7	1.8
Number of self-reported non-cancer illnesses	0.9	1.6	4.2	2.0	0.3	0.7
Mother’s age at death	0.9	1.2	2.8	-1.7	-0.3	-0.8
Cholesterol lowering medication	0.9	1.3	2.6	1.6	-0.9	0.7
Crohns Disease (2017)	0.8	1.7	3.0	-1.4	-1.7	-0.2
Ovarian Cancer	0.8	1.0	3.0	-0.2	-1.7	0.0
Fasting Glucose	0.8	1.0	2.8	1.7	0.0	0.5
Ever had hysterectomy (womb removed)	0.8	0.9	2.5	0.1	1.6	-0.4
Average weekly fortified wine intake	0.8	0.9	1.7	-0.9	-0.3	-1.3
Fed-up feelings	0.8	1.5	1.9	1.4	0.8	1.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.0	0.8	1.0	-1.0
Nervous feelings	0.8	1.4	2.1	1.2	1.5	0.8
Financial difficulties in last 2 years	0.8	1.1	1.9	1.0	0.6	1.4
Neuroticism score	0.8	1.6	3.6	1.1	1.9	0.1
Illnesses of mother	0.8	1.0	2.7	-1.6	-0.6	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.2	-0.7	0.5	-1.5
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.1	0.8	1.5	-0.2
Alcohol intake frequency.	0.8	1.8	2.4	1.5	1.0	1.4
Illnesses of father: Heart disease	0.8	1.1	3.0	1.7	0.5	-0.0
Asthma (self-reported)	0.8	1.5	3.1	1.8	-0.1	1.2
Illnesses of father: None of the above (group 1)	0.8	0.9	2.6	-1.6	-0.4	0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.8	2.9	-1.6	0.4	-1.7
Systolic Blood Pressure	0.7	3.4	6.1	1.8	1.1	2.5
Hypothyroidism (self reported)	0.7	1.6	3.8	-0.9	0.5	-1.9
Diabetes (mother)	0.7	0.9	2.0	-0.8	0.3	-1.4
Medication: Levothyroxine sodium	0.7	1.3	3.6	-0.4	0.1	-1.9
Body mass index (BMI)	0.7	3.0	4.4	2.1	1.3	1.7
Diabetes (self-reported)	0.7	1.2	1.6	1.3	0.5	1.3
Medication: Simvastatin	0.7	1.1	2.0	1.4	0.5	1.0
Hair/balding pattern: Pattern 3	0.7	1.1	2.8	0.4	1.7	-0.4
Pulse wave Arterial Stiffness index	0.7	0.8	1.6	-0.5	-0.7	-1.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.1	1.0	0.8	1.0
Exposure to tobacco smoke outside home	0.7	0.9	2.0	1.4	-0.5	0.6
Age at first live birth	0.7	1.3	2.0	-1.1	-0.7	-1.4
Shortness of breath walking on level ground	0.7	0.8	1.7	1.3	0.2	0.8
Qualifications: College or University degree	0.7	2.2	3.6	-1.6	0.6	-1.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.2	1.1	0.3	1.1
Ever taken oral contraceptive pill	0.7	0.8	2.1	-0.5	0.1	-1.5
Ever smoked	0.7	1.3	2.2	1.5	1.3	0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	0.9	0.9	1.0	-0.9
HbA1C	0.6	0.6	1.7	-0.5	-1.3	-0.3
Schizophrenia (2014)	0.6	1.3	3.2	0.8	1.8	0.2
Ulcerative Colitis	0.6	0.9	1.7	0.9	1.3	0.5
Townsend deprivation index at recruitment	0.6	0.8	1.7	1.3	0.8	0.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	1.0	1.1	-0.3
Hearing difficulty/problems with background noise	0.6	1.0	2.3	0.0	0.8	-1.5
Birth weight of first child	0.6	1.1	2.3	-1.5	-0.8	-0.5
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.6	-1.3	-0.3	-1.2
Commuting to job workplace: Public transport	0.6	0.7	1.4	-1.2	-0.4	-0.6
Alzheimer’s Disease (in father)	0.5	0.5	1.6	1.3	0.1	0.2
Reaction Time	0.5	0.9	1.6	0.2	1.3	-0.9
LDL Cholesterol	0.5	0.8	1.8	1.4	0.7	0.2
Blood White Count	0.5	3.8	4.7	2.0	-1.7	2.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.7	-1.3	-0.3	-0.5
Angina	0.5	0.6	1.0	1.0	0.5	-0.8
Supplements: Zinc	0.5	0.6	0.9	0.7	0.9	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	0.9	1.0	0.6	0.8
Stomach or abdominal pain in last month	0.5	0.6	0.8	-0.9	-0.9	-0.5
High blood pressure (mother)	0.5	0.8	1.5	-0.6	-1.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.2	1.5	0.5	1.0
Allergy	0.5	1.1	2.4	-0.7	0.6	-1.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.0	1.4	0.3	0.0
Fluid intelligence score	0.5	1.1	1.8	-1.3	0.8	-0.9
Pulse rate	0.5	0.9	2.2	1.5	0.3	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.8	-1.4	-0.5	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	2.3	-0.6	0.7	-1.5
Angina (self-reported)	0.5	0.7	1.0	0.9	0.4	-1.0
Family relationship satisfaction	0.5	0.6	1.1	-1.1	0.2	-0.8
Knee pain experienced in last month	0.5	0.8	2.3	1.5	-0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.3	0.3	1.5	-0.2
Medication: Atorvastatin	0.5	0.7	1.1	-0.2	-1.0	-0.9
Myopia	0.5	0.8	1.6	-0.7	-0.4	-1.3
Basal cell carcinoma (self-reported)	0.5	0.7	1.1	-1.1	-0.8	-0.4
Heart disease (siblings)	0.5	0.6	1.4	0.3	1.2	0.7
Crohns Disease (2012)	0.4	0.7	1.4	-0.7	-1.2	-0.3
Triglycerides	0.4	0.7	0.9	-0.9	-1.0	-0.6
Blood Platelet Count	0.4	4.2	9.0	3.0	0.8	1.7
BMI	0.4	2.6	4.1	2.0	0.8	1.7
Cardiovascular Disease	0.4	1.4	2.9	0.6	-1.0	1.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.4	-1.1	0.2
Taking other prescription medications	0.4	0.6	1.4	1.2	0.5	-0.2
Age when periods started (menarche)	0.4	1.0	1.6	1.1	1.3	0.4
Medication: Atenolol	0.4	0.5	1.0	1.0	-0.7	0.0
Past tobacco smoking	0.4	0.7	2.0	0.0	-0.2	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.1	0.5	0.3	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-0.7	0.1	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.7	0.7	0.9	-0.1
Pulse wave peak to peak time	0.4	0.5	1.0	-1.0	-0.2	0.6
Migraine (self-reported)	0.4	0.5	1.2	-0.6	-1.1	-0.2
Overall health rating	0.4	1.0	1.6	1.3	0.1	1.1
Chest pain or discomfort	0.4	0.6	1.3	1.1	0.6	-0.2
Eye problems/disorders: Cataract	0.4	0.5	1.5	0.0	-0.1	-1.2
Miserableness	0.4	0.6	1.2	0.5	1.1	-0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	0.1	-0.1	1.2
Medication: Lisinopril	0.4	0.5	0.8	0.4	-0.7	-0.9
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.0	-1.4	0.7	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.8	-0.6	-0.6	-0.9
Alcohol drinker status: Previous	0.4	0.4	1.0	1.0	0.1	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.4	-1.2	0.2	-1.1
Worry (Nagel 2018)	0.3	0.6	0.8	0.8	0.9	0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.5	-0.7	-0.8
Medication for hormone replacement therapy	0.3	0.4	1.1	-1.1	-0.1	-0.1
Vitamin and mineral supplements	0.3	0.4	0.8	-0.1	-0.7	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.6	1.3	0.4	0.7
High blood pressure	0.3	0.9	1.6	1.2	-0.6	0.9
Number of incorrect matches in round	0.3	0.5	0.9	-0.6	-1.0	0.5
Heart attack	0.3	0.4	0.9	0.9	-0.5	0.1
Pain all over the body in last month	0.3	0.3	0.6	0.5	-0.1	0.8
Illnesses of siblings	0.3	0.4	1.0	-0.5	-0.2	-1.0
Father’s age at death	0.3	0.4	0.7	-0.7	0.9	-0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	0.7	-0.1	1.0
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.7	0.3	-0.5
Birth weight	0.3	0.6	0.9	-0.7	0.6	1.0
Emphysema/chronic bronchitis	0.3	0.3	0.5	-0.5	-0.5	0.7
Medication: Ibuprofen	0.3	0.4	1.0	0.3	1.0	0.2
Pulse rate, automated reading	0.3	0.9	1.4	1.1	0.5	1.2
Had major operations	0.3	0.3	0.6	0.7	0.7	0.2
Leg pain on walking	0.3	0.4	0.8	-0.0	0.6	-0.9
Hypertension (Self-reported)	0.3	0.8	1.7	1.3	-0.2	0.9
Illnesses of siblings: Diabetes	0.3	0.4	0.7	0.5	-0.8	0.5
Mood swings	0.3	0.6	0.7	0.8	0.9	0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.6	0.8	0.4	0.5
High cholesterol (Self-reported)	0.3	0.5	1.1	0.7	-1.1	0.1
Illnesses of father: High blood pressure	0.3	0.3	0.5	0.7	0.0	0.7
Age started oral contraceptive pill	0.3	0.4	1.3	-0.0	1.1	-0.0
Diastolic blood pressure, automated reading	0.3	0.9	1.3	1.1	0.7	1.0
Pain experienced in last month	0.3	0.5	0.6	-0.7	0.8	-0.7
Supplements: Calcium	0.3	0.3	0.9	-0.3	0.1	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.4	0.9	0.0
Irritable Bowel Disease (IBD)	0.2	0.6	1.1	-1.0	-0.7	-0.2
Ulcerative Colitis (UC)	0.2	0.3	0.5	-0.7	0.3	-0.6
Major Depression (MDD)	0.2	0.2	0.6	0.8	0.0	0.0
Age at First Birth	0.2	0.3	0.5	-0.5	0.0	-0.7
HDL Cholesterol	0.2	0.3	0.6	-0.2	0.5	-0.8
Blood Eosinophil Count	0.2	1.7	4.1	-0.4	-2.0	0.9
Heel T-Score	0.2	1.9	2.9	1.7	0.3	1.6
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	0.5	0.6	0.0
Pack years adult smoking proportion	0.2	0.2	0.5	0.4	0.7	0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.7	0.9	-0.1	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	0.2	-0.6	1.0
Multivitamins +/- minerals	0.2	0.2	0.4	0.3	0.4	-0.7
Waist circumference	0.2	0.7	1.4	0.7	1.2	-0.5
Qualifications: None of the above	0.2	0.4	0.6	0.8	0.5	0.5
Time employed in main current job	0.2	0.2	0.6	-0.4	-0.1	0.7
Alcohol intake versus 10 years previously	0.2	0.4	0.8	0.5	-0.0	0.9
Happiness	0.2	0.2	0.5	-0.7	-0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.6	-0.8	0.7	-0.6
Depression (self-reported)	0.2	0.2	0.4	0.3	0.5	0.6
Gout (self-reported)	0.2	0.2	0.7	-0.8	-0.1	0.1
Medication: Amlodipine	0.2	0.3	0.7	0.9	0.3	-0.1
Comparative body size at age 10	0.2	0.7	1.3	0.2	0.9	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.3	0.1	-0.9
Health satisfaction	0.2	0.3	0.5	-0.2	-0.7	0.5
Number of full sisters	0.2	0.2	0.5	0.2	-0.7	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.4	0.2	-0.5
Medication: Aspirin	0.2	0.3	0.7	0.9	0.1	0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.9	0.0	0.3	0.9
Risk taking	0.2	0.3	0.6	-0.1	-0.5	-0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.6	-0.8	-0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	0.9	-0.4	-0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	0.1	0.9	-0.3
Breast Cancer	0.1	0.4	0.8	0.9	0.2	0.5
Mean Putamen Volume	0.1	0.1	0.2	0.3	-0.5	-0.2
Neuroticism (2016)	0.1	0.2	0.2	-0.5	0.4	-0.4
Allergy or Eczema	0.1	0.3	0.5	-0.0	-0.7	0.7
Hair Pigment	0.1	4.1	6.9	2.6	1.9	1.4
Average weekly spirits intake	0.1	0.1	0.3	0.5	-0.2	0.4
Trunk fat mass	0.1	0.4	1.0	-0.6	0.2	-1.0
Medication: Lansoprazole	0.1	0.1	0.3	0.5	0.0	-0.2
Prospective memory result	0.1	0.1	0.3	0.6	0.0	0.4
Lung cancer (father)	0.1	0.1	0.3	0.1	0.3	-0.6
Length of working week for main job	0.1	0.1	0.4	-0.2	-0.6	0.1
Breastfed as a baby	0.1	0.1	0.2	-0.5	-0.0	-0.3
Loud music exposure frequency	0.1	0.1	0.2	0.2	0.5	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.5	0.2	0.1
Heart disease (mother)	0.1	0.2	0.2	0.4	-0.4	0.4
Suffer from ‘nerves’	0.1	0.1	0.3	0.5	0.2	0.0
Medication: Aspirin	0.1	0.1	0.4	0.6	-0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.6	-0.1	-0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.1	0.4	-0.4	0.1
Ever had bowel cancer screening	0.1	0.1	0.2	-0.0	0.0	-0.5
Friendships satisfaction	0.1	0.2	0.4	-0.3	-0.0	-0.6
Qualifications: nursing, teaching	0.1	0.2	0.3	0.1	0.4	-0.6
Osteoporosis (self-reported)	0.1	0.1	0.4	0.0	0.6	-0.2
Hearing aid user	0.1	0.1	0.2	-0.0	0.3	-0.4
Financial situation satisfaction	0.1	0.2	0.4	0.3	-0.0	0.6
Medication: Bendroflumethiazide	0.1	0.1	0.4	0.2	0.1	-0.6
Average weekly beer plus cider intake	0.1	0.2	0.3	0.6	-0.2	-0.2
Pack years of smoking	0.1	0.2	0.5	0.3	0.7	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Lung FEV1/FVC ratio	0.0	0.1	0.2	0.4	-0.2	0.2
Tanning	0.0	0.1	0.3	0.2	0.5	0.2
Supplements: Glucosamine	0.0	0.1	0.2	-0.1	-0.4	-0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	0.3	-0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.1	-0.2	0.3
Worrier / anxious feelings	0.0	0.1	0.1	-0.4	-0.1	0.3
Falls in the last year	0.0	0.0	0.1	0.0	-0.3	-0.1
Arm fat mass (right)	0.0	0.0	0.1	-0.2	0.1	0.1
Glaucoma (self-reported)	0.0	0.0	0.0	-0.0	-0.2	0.2
Number of full brothers	0.0	0.1	0.1	0.1	0.3	0.1
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.1	0.3	0.0
Whole body fat mass	0.0	0.2	0.4	-0.3	0.3	-0.6
Leg fat mass (right)	0.0	0.2	0.4	0.4	0.6	-0.1
Loneliness, isolation	0.0	0.0	0.0	0.1	0.1	-0.1
Arm fat mass (left)	0.0	0.0	0.1	-0.3	0.0	-0.2
Number of operations (self-reported)	0.0	0.0	0.0	-0.1	-0.0	-0.1
Leg fat mass (left)	0.0	0.1	0.1	0.2	0.3	-0.0

Hub : Genes

SCN4A

Models

Trait associations