Hub : Genes

CCDC47

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.076 0.040 3.6e-03 0.019 NA -0.001 NA 0.009 0.03000 NA 0.3800 NA 0.0940
2 GTEx Esophagus Mucosa 0.118 0.065 2.3e-03 -0.003 NA -0.002 NA -0.001 0.60000 NA 0.4400 NA 0.3700
3 GTEx Testis 0.168 0.059 1.6e-05 0.064 NA 0.088 NA 0.080 0.00082 NA 0.0001 NA 0.0002
4 GTEx Whole Blood 0.049 0.027 6.8e-03 -0.001 NA -0.003 NA 0.005 0.38000 NA 0.8900 NA 0.0980

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.3 0.5 0.8 -0.6 -0.9 0.8 -0.4
Bipolar Disorder or Schizophrenia 0.2 0.5 0.8 0.9 0.8 -0.6 -0.6
Depressed Affect (Nagel 2018) 1.3 2.6 6.7 -0.0 0.0 -2.6 2.0
Depression (Nagel 2018) 0.6 0.8 3.0 -0.1 -0.0 -1.7 0.5
Intelligence (Savage-Jansen 2018) 2.5 7.7 11.7 3.1 3.4 0.5 -3.0
Neuroticism (Nagel 2018) 1.3 2.9 4.9 1.6 1.9 -2.2 -0.8
Schizophrenia (2018) 0.9 2.0 3.1 1.6 1.7 -1.4 -0.4
Schizophrenia vs Biploar Disorder 1.0 1.3 3.3 0.7 1.1 -1.8 -0.4
Worry (Nagel 2018) 0.9 1.9 6.6 0.2 1.0 0.3 -2.6
Alzheimer’s Disease (in mother) 3.0 3.6 6.5 1.7 1.8 -2.5 -1.3
Alzheimer’s Disease (in father) 1.3 1.4 4.3 -1.0 -0.6 -2.1 0.1
Alzheimer’s Disease (including proxy) 3.3 4.8 9.9 1.1 1.9 -3.1 -2.1
Crohns Disease (2017) 0.6 1.3 1.8 -1.2 -1.0 1.3 -1.0
Irritable Bowel Disease (IBD) 0.3 0.8 2.3 0.2 0.5 0.7 -1.5
Ulcerative Colitis (UC) 1.5 2.7 4.2 1.9 2.1 -0.1 -1.8
Major Depression (MDD) 1.1 1.3 4.9 -0.2 0.0 -0.5 2.2
Reaction Time 1.3 2.5 3.5 1.8 1.7 -1.9 0.6
Verbal and Numeric Reasoning (VNR) 2.4 5.7 8.8 3.0 2.9 -0.3 -2.3
Breast Cancer 0.5 1.1 2.7 -0.5 -0.1 -1.2 1.6
Ovarian Cancer 2.1 2.8 5.0 -2.1 -2.2 1.3 0.1
Prostate Cancer 2.1 2.9 10.1 0.3 -0.0 -3.2 1.2
Age at First Birth 3.8 5.6 9.4 2.6 2.4 0.5 -3.1
Bipolar Disorder (2011) 0.8 0.8 2.9 0.4 -0.3 1.7 0.0
Body Mass Index (BMI) (2010) 3.4 4.6 9.6 -3.1 -1.6 -0.3 2.5
Coronary Artery Disease (CAD) 1.1 1.3 2.1 1.3 1.2 0.0 -1.5
Crohns Disease (2012) 0.4 0.6 1.1 -1.0 -0.6 0.9 0.0
Mean Putamen Volume 0.2 0.2 0.8 -0.1 0.3 -0.9 0.2
Fasting Glucose 0.6 0.7 2.1 -0.8 -1.4 0.1 -0.2
HbA1C 0.5 0.6 1.0 -0.9 -1.0 0.4 -0.5
HDL Cholesterol 0.8 1.4 3.4 1.0 0.7 -1.8 -0.7
LDL Cholesterol 0.3 0.5 1.2 -0.5 -0.3 -1.1 0.6
Lupus 0.4 0.6 1.7 -0.0 0.5 -1.3 -0.6
Neuroticism (2016) 0.8 1.2 4.2 0.3 0.7 0.0 -2.1
Primary Biliary Cirrhosis 0.6 0.9 2.6 -0.9 -0.1 -1.6 0.3
Rheumatoid Arthritis 1.3 1.8 5.2 1.1 0.7 -2.3 -0.2
Schizophrenia (2014) 1.1 2.4 4.0 2.0 1.7 -1.5 -0.8
Triglycerides 0.4 0.7 2.1 -0.8 -0.1 1.4 -0.2
Type 2 Diabetes (T2D) (2012) 2.6 3.0 7.0 -2.1 -2.6 -0.7 0.6
Ulcerative Colitis 0.8 1.1 2.0 1.1 1.4 -0.0 -1.1
Blood Eosinophil Count 0.7 5.1 9.1 -3.0 -2.5 2.2 0.3
Blood Platelet Count 0.6 7.2 15.6 -4.0 -1.4 -0.7 3.3
Blood Red Count 2.6 25.1 54.6 -6.1 -2.9 7.4 0.2
Blood White Count 2.8 20.6 48.6 -7.0 -4.4 2.4 2.9
Heel T-Score 1.9 14.8 24.7 -4.5 -3.6 -1.2 5.0
BMI 2.0 11.7 20.9 -4.6 -4.4 -0.4 2.5
Height 11.2 215.1 324.0 14.6 14.3 10.9 -18.0
Waist Hip Ratio (WHR) 2.5 11.4 37.7 0.9 1.0 -6.1 2.5
Systolic Blood Pressure 0.4 1.9 6.0 -0.5 1.1 0.5 2.5
Smoking Status 1.3 3.0 11.5 -0.0 -0.5 -3.4 0.5
Allergy or Eczema 0.7 1.8 2.8 -1.7 -1.1 0.7 1.6
Cardiovascular Disease 4.3 14.3 25.9 -5.1 -3.9 2.8 2.9
Hypothyroidism (self reported) 0.5 1.2 3.3 1.8 0.6 -0.2 -1.1
Respiratory disease 2.2 4.9 8.0 -2.4 -2.8 -0.7 2.4
Type 2 Diabetes (T2D) (2018) 1.5 2.9 6.5 -2.0 -1.0 0.1 2.5
Lung FEV1/FVC ratio 1.3 6.7 12.4 -3.1 -2.1 0.2 3.5
Lung FVC 0.9 4.7 11.0 1.0 2.4 3.3 -1.1
Neuroticism 0.9 2.3 6.1 1.1 1.3 -2.5 -0.4
Chronotype (morning person) 2.2 5.0 14.6 -0.7 -0.7 2.1 -3.8
Hair Pigment 0.1 3.9 10.2 -0.0 -1.1 -3.2 2.0
Tanning 0.1 1.0 2.2 1.5 0.8 0.0 -1.1
Hand grip strength (left) 1.6 4.1 15.3 0.6 0.4 3.9 -0.8
Number of treatments/medications taken 1.1 1.9 3.1 -1.3 -0.7 -1.8 1.6
Average weekly spirits intake 0.1 0.1 0.3 -0.5 -0.2 -0.2 0.3
Sensitivity / hurt feelings 0.9 1.6 2.7 1.6 0.7 -1.6 -0.7
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.5 -0.3 -0.3 -0.7 0.3
Hearing difficulty/problems: Yes 1.1 1.7 2.6 1.6 1.4 -1.5 -0.2
Relative age of first facial hair 1.8 3.7 6.6 1.5 0.2 -2.5 2.6
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.6 -0.9 0.1 -1.3 1.1
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.4 -0.6 -0.2 1.6 -0.4
Ever had hysterectomy (womb removed) 2.3 2.5 4.4 1.3 2.1 -1.5 1.3
Systolic blood pressure, automated reading 0.3 1.0 2.8 -0.4 0.7 -0.7 1.7
Eye problems/disorders: Diabetes related eye disease 4.2 4.6 8.0 -2.3 -1.9 2.8 1.0
Angina 1.2 1.6 4.6 -0.3 -0.1 -2.1 1.3
Medication for hormone replacement therapy 0.1 0.1 0.3 0.3 -0.0 0.3 0.5
Vitamin and mineral supplements 1.4 2.0 3.5 -1.0 -0.4 1.9 -1.8
Supplements: Zinc 0.6 0.7 1.2 1.1 0.9 -0.9 -0.0
Medication: Co-codamol 0.8 0.9 1.8 -0.8 -0.3 -1.3 1.0
Medication: Metformin 0.7 1.0 2.7 0.4 0.9 -1.6 0.4
Diabetes (father) 1.2 1.5 4.7 0.7 0.7 -2.2 0.7
Diabetes (mother) 0.0 0.0 0.1 -0.1 -0.2 -0.3 0.0
Severe depression (siblings) 0.9 1.0 2.1 1.4 0.7 -1.3 0.0
Pack years adult smoking proportion 1.0 1.6 4.2 -0.8 -0.3 -1.1 -2.0
Impedance of leg (right) 0.8 3.8 11.4 1.1 0.5 -3.4 1.5
Leg fat-free mass (left) 3.9 20.8 32.3 3.4 3.4 5.2 -5.7
Trunk fat percentage 0.6 2.6 6.7 -0.5 -0.7 -2.6 1.7
Hand grip strength (right) 2.5 6.7 17.8 1.8 2.2 4.2 -1.0
Townsend deprivation index at recruitment 0.8 1.1 3.0 -0.1 -0.7 -1.7 0.8
Current tobacco smoking 1.8 3.0 10.0 1.2 0.6 -3.2 -0.3
Average weekly fortified wine intake 3.0 3.5 6.8 1.7 2.6 -0.1 -2.1
Maternal smoking around birth 1.5 2.1 3.8 -1.9 -1.5 1.5 -0.6
Fed-up feelings 1.1 1.9 3.3 -1.8 -0.4 -1.3 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.1 -1.4 -0.4 -1.1 0.5
Relative age voice broke 1.6 2.5 6.3 0.6 -0.2 -1.8 2.5
Taking other prescription medications 2.5 3.8 5.2 -1.7 -1.8 -2.0 2.3
Age when periods started (menarche) 0.2 0.6 1.3 -0.3 0.4 -0.8 1.1
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.8 0.8 1.7 -0.5 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.9 4.3 -2.1 -2.0 -0.7 1.6
Tinnitus: Yes, but not now, but have in the past 3.0 3.2 6.9 0.6 0.2 -2.6 2.3
Qualifications: CSEs or equivalent 0.7 0.9 1.2 -0.8 -1.0 -0.8 1.1
Serious illness, injury or assault to yourself 1.4 1.7 4.7 0.4 -0.7 -2.2 1.1
High blood pressure 1.3 3.7 7.6 -2.8 -1.9 0.4 1.9
Hayfever, allergic rhinitis or eczema 0.8 1.6 3.2 -1.6 -0.6 0.6 1.8
Multivitamins +/- minerals 1.1 1.4 2.7 1.1 0.2 -1.7 1.2
Stomach or abdominal pain in last month 0.1 0.1 0.2 0.2 0.5 0.3 0.1
Supplements: Glucosamine 0.2 0.2 0.3 -0.3 -0.5 -0.5 0.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.7 0.5 0.3 0.2 -0.8
Medication: Atenolol 1.4 1.7 3.8 -1.1 -1.3 0.0 2.0
Medication: Levothyroxine sodium 0.1 0.2 0.4 0.7 -0.6 -0.1 -0.4
Sitting height 7.0 49.4 78.5 4.5 5.5 8.9 -8.3
Chronic bronchitis/emphysema (father) 0.9 1.1 2.5 -0.2 -0.9 -1.6 -1.0
High blood pressure (mother) 0.9 1.2 1.7 -1.3 -0.7 1.1 1.1
Body mass index (BMI) 1.2 5.3 10.0 -3.2 -2.5 -1.0 1.9
Impedance of leg (left) 1.0 5.1 14.3 0.9 1.1 -3.8 2.0
Leg predicted mass (left) 3.9 20.7 31.6 3.4 3.4 5.3 -5.6
Trunk fat mass 0.1 0.4 0.5 0.7 0.7 -0.5 -0.7
Waist circumference 0.4 1.4 5.4 -0.1 0.2 -2.3 -0.5
Number of incorrect matches in round 0.4 0.7 1.9 -1.4 -0.7 0.2 -0.4
Past tobacco smoking 0.3 0.5 1.6 0.5 0.5 1.3 -0.1
Alcohol usually taken with meals 1.5 2.5 8.5 -0.7 -0.2 2.9 1.0
Nervous feelings 1.1 2.0 3.1 1.5 0.7 -1.5 -1.8
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 5.5 0.0 0.5 -2.3 0.7
Hearing difficulty/problems with background noise 2.1 3.3 5.1 1.8 1.7 -2.3 -1.4
Hair/balding pattern: Pattern 2 0.9 1.2 2.7 -1.6 -0.6 1.2 0.1
Had menopause 0.5 0.6 1.3 0.4 0.5 0.9 -1.1
Had other major operations 0.7 0.8 1.5 -1.2 -0.6 1.2 0.1
Forced vital capacity (FVC) 7.7 29.7 34.2 5.3 5.8 5.5 -5.1
Heel bone mineral density (BMD) T-score, automated (right) 1.7 4.0 7.0 -2.0 -2.7 -0.7 2.0
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 2.1 -1.4 -1.1 -0.1 1.5
Qualifications: None of the above 0.4 0.9 1.8 -1.4 -1.2 -0.1 -0.5
Financial difficulties in last 2 years 1.6 2.1 3.6 -1.3 -1.3 -1.2 1.9
Mouth/teeth dental problems 0.7 1.1 2.0 -0.2 -1.1 1.0 1.4
Heart attack 1.1 1.5 2.0 -1.2 -1.2 -0.9 1.4
Allergy 1.3 2.9 6.7 2.6 1.4 -0.3 -1.7
Pain all over the body in last month 0.7 0.7 2.1 -0.7 -0.5 -1.4 0.3
Diabetes (self-reported) 0.5 0.8 1.4 -1.2 -0.1 -0.8 1.0
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.3 -0.2 -0.2 -1.0 1.1
Medication: Ramipril 0.6 0.8 2.2 -1.0 -0.2 -1.5 0.4
Medication: Simvastatin 1.2 1.8 3.3 -1.6 -1.8 -0.0 1.1
Fluid intelligence score 2.2 4.6 7.5 2.4 2.7 0.2 -2.2
Illnesses of siblings 3.2 4.5 8.1 2.8 1.6 -0.8 -2.6
Neuroticism score 0.9 1.8 3.7 1.2 1.4 -1.9 -0.3
Weight 1.4 7.1 13.1 1.8 2.1 2.7 -3.6
Impedance of arm (right) 1.4 6.7 12.7 3.6 1.4 -3.4 0.9
Arm fat percentage (right) 1.3 5.2 6.1 -2.0 -2.2 -2.5 2.4
Trunk fat-free mass 6.9 39.3 61.6 4.1 4.6 7.6 -7.8
Hip circumference 0.7 3.0 6.1 0.7 0.6 2.5 -2.3
Time employed in main current job 0.8 0.9 1.7 -1.0 0.3 0.9 -1.3
Alcohol intake versus 10 years previously 1.6 2.4 5.2 -2.3 -0.4 -0.8 1.9
Father’s age at death 0.5 0.6 1.4 1.2 1.0 0.2 0.4
Worrier / anxious feelings 1.6 3.0 9.5 1.0 1.2 0.2 -3.1
Frequency of tiredness / lethargy in last 2 weeks 3.1 5.0 17.1 0.1 0.8 -4.1 1.4
Falls in the last year 0.0 0.1 0.1 0.3 -0.2 -0.2 0.2
Hair/balding pattern: Pattern 3 3.3 4.9 13.0 3.6 1.5 -1.7 -1.2
Number of live births 0.4 0.6 1.1 1.1 0.5 -0.9 -0.6
Forced expiratory volume in 1-second (FEV1) 4.7 15.9 26.5 3.5 4.0 5.2 -2.9
Pulse rate 1.1 1.9 3.1 -0.8 -1.3 -1.8 1.5
Happiness 0.2 0.2 0.8 -0.3 -0.3 0.9 -0.1
Noisy workplace 0.3 0.4 0.8 -0.2 -0.4 -0.9 0.7
Qualifications: A levels/AS levels or equivalent 1.1 2.5 5.0 2.2 1.4 -0.1 -1.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.8 -0.1 0.9 -0.2 0.1
Mouth/teeth dental problems: Dentures 0.6 1.0 2.8 -1.7 -0.4 0.8 -0.6
Asthma 2.7 5.3 8.8 -2.4 -2.6 -0.2 3.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.1 0.1 1.0 -0.1 -0.2
Medication: Cholesterol lowering 1.1 1.7 2.7 -1.3 -1.6 -0.3 1.5
Depression (self-reported) 0.3 0.4 1.5 -0.1 -0.4 0.0 1.2
Medication: Lansoprazole 0.1 0.1 0.4 -0.6 -0.3 0.0 0.2
Prospective memory result 1.2 1.5 3.2 -1.8 -1.4 0.8 0.3
Lung cancer (father) 5.0 5.9 7.6 2.2 2.8 -2.5 -2.3
Illnesses of mother 2.5 3.1 5.7 1.1 0.1 2.4 -2.4
Forced expiratory volume in 1-second (FEV1), Best measure 4.5 14.5 28.9 2.8 3.6 5.4 -2.8
Pulse wave Arterial Stiffness index 0.6 0.7 1.4 0.9 0.5 -0.3 -1.2
Impedance of arm (left) 1.2 5.4 9.7 3.1 1.2 -3.1 1.1
Arm fat mass (right) 0.1 0.5 1.0 -1.0 -0.9 0.1 0.2
Trunk predicted mass 6.7 38.6 59.8 4.0 4.5 7.6 -7.7
Standing height 10.6 105.1 144.0 10.2 9.5 9.0 -12.0
Length of working week for main job 0.3 0.3 0.8 -0.9 -0.3 -0.2 0.5
Exposure to tobacco smoke at home 1.1 1.3 3.0 -1.7 -1.4 -0.3 0.2
Breastfed as a baby 0.5 0.6 0.8 0.9 0.0 -0.9 0.8
Tense / ‘highly strung’ 0.7 1.1 3.0 -1.2 -0.2 0.2 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.9 -1.0 -0.1 0.2 1.4
Hair/balding pattern: Pattern 4 0.5 1.2 1.8 1.1 1.3 1.4 -0.4
Birth weight of first child 0.5 0.9 2.0 0.1 1.4 1.2 -0.2
Peak expiratory flow (PEF) 3.9 9.2 33.6 0.0 1.0 5.8 -1.4
Pulse wave reflection index 0.5 0.6 1.5 -0.6 -1.2 0.2 -0.8
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.3 0.6 0.5 -1.5 0.0
Loud music exposure frequency 0.0 0.0 0.1 0.1 0.0 -0.1 0.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 3.4 1.8 1.2 -0.3 -1.0
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.2 -1.1 -0.3 -0.8 0.5
Blood clot in the leg (DVT) 0.2 0.2 0.5 0.3 0.2 -0.7 0.5
Medication: Paracetamol 1.9 3.2 6.6 -0.9 0.3 -2.6 2.2
Headache pain in last month 1.7 3.0 7.5 -1.3 -1.3 -1.0 2.7
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 4.6 2.1 1.6 -0.1 -1.8
Glaucoma (self-reported) 2.0 2.3 6.5 -0.9 -1.4 0.1 2.6
Gout (self-reported) 1.0 1.3 2.7 0.1 0.4 1.5 -1.6
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 3.6 1.9 0.8 -0.7 -1.1
Medication: Amlodipine 0.7 0.9 2.1 -1.1 -0.5 -0.0 1.5
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.3 -0.6 -0.5 -1.1 -1.5
Birth weight 1.1 2.4 4.2 1.9 1.4 0.0 -2.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 0.9 -0.9 -0.8 -0.1 -0.9
High blood pressure (siblings) 4.9 7.0 9.5 -3.1 -2.2 2.6 2.7
Forced vital capacity (FVC), Best measure 6.8 24.8 32.6 4.5 5.3 5.7 -4.3
Body fat percentage 1.2 4.7 9.1 -1.5 -1.4 -3.0 2.4
Leg fat percentage (right) 2.0 7.3 10.8 -2.6 -2.1 -3.3 2.7
Arm fat-free mass (right) 4.9 25.1 39.9 2.8 4.0 6.3 -6.0
Exposure to tobacco smoke outside home 1.5 2.0 4.7 -2.2 -1.8 -0.2 -0.0
Comparative body size at age 10 0.9 2.5 4.3 1.7 2.1 -0.6 -1.6
Number of full brothers 0.5 0.6 1.1 -0.1 -0.7 -0.9 1.0
Worry too long after embarrassment 6.0 10.1 15.1 3.9 3.8 -2.8 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.5 0.3 0.7 -1.6 0.4
Wheeze or whistling in the chest in last year 1.5 2.6 8.2 -1.1 -0.6 -2.9 0.8
Number of children fathered 0.4 0.5 1.7 0.1 -0.3 1.3 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 2.3 1.4 1.5 -1.1 -1.0
Age at first live birth 0.1 0.2 0.3 0.1 -0.5 0.6 -0.2
Pulse wave peak to peak time 0.3 0.4 1.3 -0.1 0.3 1.2 -0.0
Health satisfaction 0.2 0.2 0.8 -0.9 0.1 0.2 0.3
Shortness of breath walking on level ground 0.7 0.8 1.3 -1.1 -0.8 -1.1 0.5
Qualifications: College or University degree 2.7 8.4 20.2 4.5 3.2 -1.0 -1.4
Eye problems/disorders: None of the above 3.4 3.9 7.6 1.9 2.1 0.0 -2.8
Mouth/teeth dental problems: Loose teeth 2.1 2.5 3.9 1.8 1.4 -2.0 -0.9
Emphysema/chronic bronchitis 0.6 0.6 2.2 -1.5 -0.2 0.3 -0.5
Medication for pain relief, constipation, heartburn 1.2 2.1 4.1 1.4 -0.5 2.0 -1.5
Neck or shoulder pain in last month 0.7 1.1 3.3 0.0 0.4 -1.8 0.9
Medication: Blood pressure 1.2 2.2 3.9 -1.1 -1.4 -1.2 2.0
Angina (self-reported) 1.3 1.7 4.6 -0.3 -0.2 -2.1 1.4
Migraine (self-reported) 0.9 1.1 2.4 -0.9 -1.5 0.6 0.9
Medication: Ibuprofen 0.2 0.3 0.7 0.1 0.8 -0.6 0.1
Medication: Allopurinol 1.0 1.4 3.1 0.1 0.4 1.5 -1.8
Medication: Omeprazole 1.0 1.2 2.2 -1.1 -0.1 -1.5 1.2
Medication: Seretide 50 evohaler 1.2 1.4 4.2 -0.8 -0.2 -0.9 2.1
Mean time to correctly identify matches 3.5 6.6 9.9 2.9 2.9 -3.1 -0.1
Heart disease (mother) 1.4 1.7 3.2 -1.7 -0.1 -0.8 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.3 0.9 -0.1 -1.8 0.8
Whole body fat mass 0.0 0.1 0.2 -0.1 0.1 -0.5 -0.2
Leg fat mass (right) 0.1 0.4 1.0 -0.7 -0.4 -1.0 0.1
Arm predicted mass (right) 4.3 22.1 36.0 2.6 3.8 6.0 -5.6
Pulse rate, automated reading 0.4 1.2 3.6 -0.8 -0.2 -0.8 1.9
Alcohol intake frequency. 0.8 1.8 3.6 -1.0 -0.8 -1.9 1.5
Comparative height size at age 10 10.5 57.9 93.7 7.0 6.7 6.6 -9.7
Number of full sisters 0.6 0.7 1.3 -0.9 -0.3 0.8 1.1
Suffer from ‘nerves’ 0.4 0.7 1.4 -0.2 0.6 -1.2 -0.9
Overall health rating 0.8 1.6 2.3 -1.3 -0.8 -1.5 1.4
Chest pain or discomfort 1.3 1.9 4.1 -0.6 -0.3 -2.0 1.7
Had major operations 0.4 0.5 0.8 0.6 -0.9 -0.4 -0.7
Age at last live birth 0.2 0.2 0.5 0.6 0.1 0.4 -0.7
Family relationship satisfaction 0.8 0.9 3.2 0.6 0.1 0.4 -1.8
Leg pain on walking 0.7 0.9 1.6 1.3 1.2 -0.6 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.2 -0.4 -0.4 -1.5 0.6
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.8 -0.3 -0.2 0.1 1.3
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 3.0 1.7 0.9 0.6 -1.4
Medication: Aspirin 0.5 0.7 2.1 -1.5 -0.8 0.1 -0.3
Supplements: Vitamin C 0.3 0.3 0.7 0.4 -0.6 -0.2 0.8
Knee pain experienced in last month 0.8 1.2 2.3 -1.2 -0.9 -1.5 0.6
Hypertension (Self-reported) 1.5 4.1 7.9 -2.8 -2.2 0.5 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 2.4 -1.6 -1.4 -1.3 1.5
Illnesses of father: Heart disease 1.1 1.6 2.1 -1.4 -0.9 -1.4 1.2
Illnesses of siblings: Diabetes 1.1 1.4 2.4 -1.5 -1.3 -0.8 0.9
Smoking status: Previous 0.2 0.2 0.7 -0.8 -0.4 0.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 4.8 9.9 14.3 3.8 3.2 2.8 -2.7
Whole body fat-free mass 5.5 31.4 48.0 3.8 4.3 6.7 -6.9
Leg fat-free mass (right) 4.1 22.1 31.6 3.5 3.8 5.5 -5.6
Arm fat percentage (left) 1.3 5.2 6.6 -2.0 -2.1 -2.4 2.6
Average weekly red wine intake 0.7 1.1 2.9 0.5 0.5 1.7 -1.0
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 0.3 -0.8 -0.1 -0.5
Mood swings 0.3 0.6 1.0 -0.7 -0.1 -1.0 0.8
Loneliness, isolation 0.5 0.8 1.5 -1.1 -1.2 0.5 0.3
Long-standing illness, disability or infirmity 2.6 3.9 8.5 -2.4 -1.2 -0.4 2.9
Ever had bowel cancer screening 1.5 1.7 4.4 1.0 2.1 -0.3 -1.2
Diabetes diagnosed by doctor 0.5 0.9 2.2 -0.5 0.4 -1.0 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.4 1.2 1.0 -0.4 -0.1
Friendships satisfaction 0.3 0.4 0.6 0.5 0.8 0.4 -0.7
Qualifications: nursing, teaching 0.4 0.6 1.8 1.3 0.1 0.1 -0.8
Commuting to job workplace: Walk 0.2 0.2 0.7 -0.2 -0.2 0.8 0.1
Eye problems/disorders: Cataract 0.6 0.6 2.2 0.6 -0.1 -1.5 0.1
Mouth/teeth dental problems: Mouth ulcers 2.8 4.4 7.4 2.7 2.3 -0.7 -2.1
Medication for cholesterol 4.5 6.8 10.6 3.3 2.8 -1.4 -2.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 2.5 1.1 1.2 -1.6 1.1
Back pain experienced in last month 1.9 2.7 4.1 -1.8 -1.8 0.5 2.0
Mineral and other dietary supplements 0.1 0.2 0.6 0.1 0.5 -0.8 0.1
Breast cancer (self-reported) 1.9 2.2 4.6 -0.4 0.7 1.9 -2.1
Asthma (self-reported) 2.6 5.1 7.7 -2.5 -2.6 -0.1 2.8
Osteoporosis (self-reported) 0.4 0.5 1.0 -0.4 0.5 1.0 -0.8
Osteoarthritis (self-reported) 1.0 1.3 4.5 -0.5 -0.5 -2.1 0.2
Medication: Aspirin 0.5 0.6 1.9 -1.4 -0.7 -0.1 -0.2
Medication: Gliclazide 1.3 1.5 3.1 0.2 0.4 -1.8 1.7
Illnesses of father: None of the above (group 1) 0.8 1.0 2.5 1.0 0.5 1.6 -0.6
Smoking status: Current 1.6 2.6 9.1 1.1 0.3 -3.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.4 7.7 0.5 1.2 2.8 -0.3
Whole body water mass 5.5 31.3 47.2 3.7 4.2 6.8 -6.9
Leg predicted mass (right) 4.1 21.8 31.0 3.5 3.7 5.5 -5.6
Arm fat mass (left) 0.1 0.3 0.6 -0.8 -0.7 -0.0 0.3
Number of self-reported non-cancer illnesses 2.3 4.0 6.0 -2.4 -2.3 -1.0 1.9
Average weekly champagne plus white wine intake 0.5 0.8 1.3 -0.6 -1.1 0.8 0.7
Miserableness 1.8 3.1 7.7 1.6 1.0 -2.8 1.0
Guilty feelings 3.4 5.1 8.2 2.0 2.9 -2.4 -1.5
Wears glasses or contact lenses 0.0 0.0 0.1 0.1 -0.3 -0.2 -0.1
Ever taken oral contraceptive pill 0.9 1.0 1.5 1.2 0.8 -1.2 0.7
Hearing aid user 0.4 0.5 1.5 -0.4 -0.3 -0.3 1.2
Mother’s age at death 0.9 1.1 2.2 1.0 0.3 1.0 -1.5
Financial situation satisfaction 0.7 0.9 2.5 -0.9 -0.2 0.4 1.6
Tinnitus: Yes, now most or all of the time 1.3 1.5 4.1 1.1 2.0 0.6 -0.3
Commuting to job workplace: Public transport 0.2 0.3 0.6 0.6 0.8 0.2 -0.3
Eye problems/disorders: Glaucoma 2.1 2.5 6.4 -1.3 -1.5 0.1 2.5
Medication: Blood pressure 2.4 4.5 9.0 -3.0 -1.8 2.0 1.4
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.9 -1.4 -0.2 -0.4 -0.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.0 0.8 0.5 1.0 -0.5
High cholesterol (Self-reported) 2.6 4.6 10.2 -3.2 -2.1 1.2 1.6
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.3 -0.5 0.1 0.3
Medication: Paracetamol 3.2 5.0 13.9 -0.1 0.6 -3.7 2.4
Medication: Lisinopril 0.4 0.5 1.0 -1.0 -0.2 -0.9 -0.1
Medication: Atorvastatin 2.0 2.4 4.7 -2.0 -2.2 1.0 0.3
Illnesses of father: High blood pressure 1.1 1.3 3.6 -1.1 -0.3 0.6 1.9
Alcohol drinker status: Never 2.5 3.0 7.9 1.9 0.7 -2.8 -0.6
Ever smoked 0.8 1.4 3.0 -0.5 -1.2 -1.7 0.9
Basal metabolic rate 4.5 24.8 38.3 3.4 3.8 5.9 -6.2
Leg fat percentage (left) 2.2 7.9 11.5 -2.9 -1.9 -3.4 2.9
Arm fat-free mass (left) 4.1 20.7 36.6 2.5 3.4 6.0 -5.3
Number of operations (self-reported) 0.3 0.5 1.8 -0.2 -1.3 0.3 0.2
Average weekly beer plus cider intake 1.5 2.2 7.2 -0.8 -0.4 -2.7 0.9
Irritability 2.2 3.8 5.8 2.3 2.4 -2.0 -0.3
Risk taking 0.6 0.9 1.4 0.4 -0.9 -1.0 1.2
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.0 -0.3 -1.0 0.2 -0.7
Fractured/broken bones in last 5 years 1.0 1.3 2.3 0.9 -0.5 1.4 -1.5
Age started oral contraceptive pill 0.7 0.9 3.0 0.5 -0.0 0.4 1.7
Diastolic blood pressure, automated reading 0.1 0.4 1.2 0.6 1.1 -0.0 -0.3
Ever depressed for a whole week 0.1 0.2 0.3 0.1 -0.5 0.4 -0.6
Unable to work because of sickness or disability 0.8 1.0 3.2 0.1 -0.6 -0.7 1.8
Commuting to job workplace: Cycle 0.8 1.0 1.9 0.8 0.8 1.4 -0.8
Myopia 0.4 0.6 1.6 1.2 0.8 -0.5 -0.1
Vascular/heart problems diagnosed by doctor 1.6 4.4 8.5 2.9 2.3 -0.2 -1.9
Cholesterol lowering medication 4.6 6.8 14.4 -3.8 -2.9 0.7 2.1
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.9 -1.4 -0.2 -1.3 0.7
Pain experienced in last month 1.1 1.9 4.8 2.2 1.2 -0.5 -1.0
Supplements: Calcium 0.1 0.2 0.5 0.2 -0.7 0.3 -0.2
Basal cell carcinoma (self-reported) 0.3 0.4 1.3 -0.1 -0.5 -0.2 -1.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.2 -0.9 -0.8 -1.0 1.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.6 0.2 0.1 -0.8 0.6
Heart disease (siblings) 0.1 0.1 0.3 -0.2 0.4 -0.5 0.3
Alcohol drinker status: Previous 0.8 0.9 2.2 0.3 0.8 -1.5 0.7
Pack years of smoking 1.1 1.6 4.2 -1.1 -0.4 -0.8 -2.0
Impedance of whole body 1.0 5.1 12.0 2.0 0.8 -3.5 1.9
Leg fat mass (left) 0.1 0.5 1.1 -1.1 -0.4 -0.8 0.3
Arm predicted mass (left) 3.7 18.6 33.6 2.2 3.1 5.8 -5.1