Best TWAS P=8.44e-69 · Best GWAS P=3.24e-60 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PEPD | 0.30 | 0.25 | lasso | 6 | 0.26 | 2.5e-21 | -12.84 | -13.9 | 8.3e-44 | -0.41 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | PEPD | 0.15 | 0.05 | enet | 10 | 0.03 | 1.3e-02 | -12.50 | -14.8 | 1.4e-49 | -0.44 | 0.06 | 0.60 | FALSE |
| 3 | GTEx | Brain Cerebellum | CEBPG | 0.48 | 0.03 | lasso | 9 | 0.08 | 1.9e-03 | 10.43 | -7.8 | 8.0e-15 | -0.31 | 0.05 | 0.22 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | PEPD | 0.16 | 0.06 | lasso | 4 | 0.04 | 3.5e-03 | -12.84 | -12.0 | 4.2e-33 | -0.24 | 0.89 | 0.01 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | PEPD | 0.12 | 0.00 | lasso | 3 | -0.01 | 6.7e-01 | -5.90 | -12.5 | 1.0e-35 | -0.45 | 0.03 | 0.41 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | PEPD | 0.18 | 0.09 | lasso | 6 | 0.12 | 3.8e-09 | 11.43 | -8.7 | 3.8e-18 | -0.24 | 0.97 | 0.00 | TRUE |
| 7 | GTEx | Colon Transverse | PEPD | 0.14 | 0.16 | lasso | 2 | 0.13 | 1.2e-06 | -12.84 | -12.7 | 8.9e-37 | -0.35 | 0.50 | 0.38 | FALSE |
| 8 | GTEx | Esophagus Mucosa | PEPD | 0.37 | 0.32 | enet | 20 | 0.39 | 9.5e-28 | -12.92 | -10.9 | 1.5e-27 | -0.17 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Muscle Skeletal | PEPD | 0.08 | 0.03 | lasso | 4 | 0.04 | 1.3e-04 | 3.57 | -5.9 | 3.8e-09 | 0.05 | 0.66 | 0.01 | FALSE |
| 10 | GTEx | Pancreas | LRP3 | 0.16 | 0.06 | lasso | 5 | 0.10 | 5.0e-05 | 8.88 | -7.5 | 4.4e-14 | -0.17 | 0.11 | 0.04 | FALSE |
| 11 | GTEx | Prostate | CEP89 | 0.36 | 0.03 | lasso | 6 | 0.02 | 8.6e-02 | 14.53 | 12.2 | 4.7e-34 | 0.65 | 0.07 | 0.11 | TRUE |
| 12 | GTEx | Skin Sun Exposed Lower leg | CTD-2085J24.4 | 0.17 | 0.06 | enet | 31 | 0.06 | 5.0e-06 | -0.33 | -5.9 | 3.2e-09 | -0.13 | 0.91 | 0.00 | TRUE |
| 13 | GTEx | Uterus | GPATCH1 | 0.32 | -0.01 | enet | 20 | 0.06 | 2.0e-02 | -1.65 | -6.1 | 1.3e-09 | -0.11 | 0.06 | 0.06 | TRUE |
| 14 | METSIM | Adipose | CHST8 | 0.22 | 0.17 | lasso | 4 | 0.17 | 3.7e-25 | -12.92 | -12.9 | 4.8e-38 | -0.39 | 1.00 | 0.00 | FALSE |
| 15 | METSIM | Adipose | PEPD | 0.19 | 0.18 | lasso | 5 | 0.17 | 2.3e-24 | -12.92 | -12.9 | 3.9e-38 | -0.35 | 1.00 | 0.00 | FALSE |
| 16 | YFS | Blood | CEBPA | 0.11 | 0.02 | bslmm | 447 | 0.04 | 1.9e-14 | 4.50 | 7.0 | 3.5e-12 | 0.23 | 0.99 | 0.00 | TRUE |
| 17 | YFS | Blood | CEBPG | 0.08 | 0.05 | bslmm | 455 | 0.05 | 5.0e-17 | -12.34 | 12.7 | 5.9e-37 | 0.49 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PEPD | 0.06 | 0.01 | blup | 114 | 0.04 | 2.6e-04 | -8.68 | -12.3 | 1.5e-34 | -0.20 | 0.31 | 0.04 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PEPD | 0.03 | 0.01 | blup | 113 | 0.02 | 1.6e-05 | 10.64 | -10.9 | 7.4e-28 | -0.19 | 0.46 | 0.01 | TRUE |
| 20 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CEBPA | 0.14 | 0.00 | blup | 39 | 0.07 | 1.6e-04 | -4.85 | 17.5 | 8.4e-69 | 0.33 | 0.01 | 0.30 | TRUE |
| 21 | The Cancer Genome Atlas | Colon Adenocarcinoma | PEPD | 0.13 | 0.06 | blup | 113 | 0.10 | 1.2e-06 | -12.90 | -10.4 | 2.8e-25 | -0.10 | 0.90 | 0.00 | FALSE |
| 22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PEPD | 0.04 | 0.05 | blup | 113 | 0.03 | 1.9e-04 | 3.57 | -6.5 | 5.6e-11 | 0.05 | 0.66 | 0.01 | FALSE |
| 23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PEPD | 0.07 | 0.00 | blup | 113 | 0.04 | 1.5e-05 | -8.23 | -12.0 | 3.5e-33 | -0.23 | 0.37 | 0.02 | TRUE |
| 24 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PEPD | 0.17 | 0.05 | blup | 114 | 0.12 | 4.1e-07 | 10.70 | -11.8 | 4.7e-32 | -0.27 | 0.61 | 0.02 | FALSE |
| 25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PEPD | 0.05 | 0.03 | blup | 113 | 0.05 | 7.1e-07 | -5.83 | -6.3 | 3.9e-10 | 0.12 | 0.92 | 0.00 | FALSE |
| 26 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PEPD | 0.16 | 0.07 | lasso | 3 | 0.05 | 3.1e-03 | -8.64 | -9.8 | 1.3e-22 | -0.15 | 0.24 | 0.03 | FALSE |
| 27 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PEPD | 0.07 | 0.00 | blup | 113 | 0.02 | 1.0e-02 | 11.43 | -5.6 | 2.4e-08 | -0.01 | 0.04 | 0.03 | FALSE |
| 28 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PEPD | 0.08 | 0.02 | blup | 113 | 0.02 | 7.0e-03 | 11.43 | -11.4 | 3.1e-30 | -0.24 | 0.07 | 0.09 | FALSE |