Best TWAS P=2.92e-15 · Best GWAS P=6.76e-16 conditioned to 0.207
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HTR1D | 0.11 | 0.07 | enet | 21 | 0.09 | 1.1e-10 | 5.5 | -5.8 | 7.3e-09 | 0.44 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | ZNF436 | 0.22 | 0.16 | lasso | 1 | 0.15 | 2.3e-12 | 5.1 | 5.1 | 2.7e-07 | -0.10 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | LUZP1 | 0.15 | 0.08 | lasso | 7 | 0.09 | 1.8e-05 | -4.6 | -5.1 | 3.0e-07 | 0.47 | 0.10 | 0.66 | FALSE |
| 4 | GTEx | Adrenal Gland | ZNF436 | 0.54 | 0.57 | lasso | 5 | 0.53 | 2.4e-22 | 5.1 | 5.2 | 1.6e-07 | -0.10 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Aorta | ZNF436 | 0.43 | 0.34 | enet | 17 | 0.39 | 1.3e-22 | 5.1 | 5.4 | 5.3e-08 | -0.15 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Brain Hypothalamus | TCEA3 | 0.33 | 0.18 | enet | 31 | 0.10 | 3.0e-03 | -8.1 | -5.5 | 5.1e-08 | 0.55 | 0.00 | 0.94 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | ZNF436 | 0.25 | 0.14 | enet | 14 | 0.16 | 1.9e-08 | 5.1 | 6.3 | 2.7e-10 | -0.13 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | ZNF436 | 0.32 | 0.15 | enet | 20 | 0.14 | 4.2e-05 | 5.1 | 5.3 | 1.0e-07 | -0.15 | 0.41 | 0.06 | FALSE |
| 9 | GTEx | Colon Transverse | ZNF436 | 0.56 | 0.40 | lasso | 3 | 0.43 | 2.9e-22 | 5.1 | 5.2 | 2.2e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Esophagus Mucosa | ZNF436 | 0.17 | 0.09 | lasso | 4 | 0.12 | 1.6e-08 | 5.1 | 6.4 | 1.2e-10 | -0.30 | 0.90 | 0.08 | FALSE |
| 11 | GTEx | Esophagus Muscularis | ZNF436 | 0.37 | 0.36 | lasso | 4 | 0.36 | 1.4e-22 | 5.1 | 5.3 | 1.5e-07 | -0.13 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Esophagus Muscularis | RP1-184J9.2 | 0.07 | 0.08 | enet | 6 | 0.05 | 6.1e-04 | 5.4 | -6.1 | 8.4e-10 | 0.56 | 0.20 | 0.73 | FALSE |
| 13 | GTEx | Heart Left Ventricle | TCEA3 | 0.26 | 0.06 | enet | 30 | 0.18 | 5.6e-10 | -8.1 | -7.6 | 3.5e-14 | 0.59 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Liver | ZNF436 | 0.58 | 0.18 | lasso | 6 | 0.27 | 3.7e-08 | 5.1 | 5.6 | 1.8e-08 | -0.12 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Lung | ZNF436 | 0.21 | 0.08 | lasso | 5 | 0.08 | 1.4e-06 | 5.0 | 5.6 | 2.3e-08 | -0.08 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Muscle Skeletal | TCEA3 | 0.23 | 0.09 | enet | 24 | 0.17 | 9.6e-17 | 5.1 | -6.7 | 2.5e-11 | 0.61 | 0.08 | 0.92 | FALSE |
| 17 | GTEx | Nerve Tibial | ZNF436 | 0.55 | 0.53 | lasso | 8 | 0.53 | 1.7e-43 | 5.1 | 5.4 | 8.5e-08 | -0.10 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Pituitary | ZNF436 | 0.66 | 0.53 | lasso | 5 | 0.45 | 1.0e-12 | 5.0 | 5.1 | 2.8e-07 | -0.16 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Prostate | ZNF436 | 0.40 | 0.44 | lasso | 1 | 0.43 | 5.4e-12 | 5.1 | 5.1 | 2.7e-07 | -0.10 | 0.95 | 0.00 | FALSE |
| 20 | GTEx | Skin Not Sun Exposed Suprapubic | ZNF436 | 0.50 | 0.39 | lasso | 3 | 0.38 | 6.0e-22 | 5.1 | 5.1 | 2.8e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | ZNF436 | 0.45 | 0.50 | lasso | 3 | 0.50 | 7.5e-48 | 5.1 | 5.4 | 6.9e-08 | -0.10 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Skin Sun Exposed Lower leg | LUZP1 | 0.07 | 0.03 | enet | 13 | 0.07 | 1.2e-06 | 3.8 | -5.8 | 6.0e-09 | 0.56 | 0.02 | 0.95 | TRUE |
| 23 | GTEx | Small Intestine Terminal Ileum | ZNF436 | 0.67 | 0.38 | lasso | 3 | 0.37 | 3.6e-09 | 5.1 | 5.5 | 4.0e-08 | -0.12 | 0.87 | 0.01 | FALSE |
| 24 | GTEx | Stomach | ZNF436 | 0.57 | 0.45 | lasso | 2 | 0.44 | 6.0e-23 | 5.1 | 5.2 | 2.5e-07 | -0.10 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Thyroid | ZNF436 | 0.42 | 0.41 | lasso | 5 | 0.41 | 6.4e-34 | 5.1 | 5.3 | 1.4e-07 | -0.10 | 1.00 | 0.00 | FALSE |
| 26 | METSIM | Adipose | ZNF436 | 0.14 | 0.13 | lasso | 2 | 0.13 | 5.6e-19 | 5.5 | 5.8 | 4.9e-09 | -0.16 | 1.00 | 0.00 | FALSE |
| 27 | ROSMAP | Brain Pre-frontal Cortex | HTR1D | 0.10 | 0.10 | lasso | 4 | 0.12 | 1.3e-14 | 5.5 | -7.3 | 2.6e-13 | 0.68 | 0.76 | 0.24 | FALSE |
| 28 | YFS | Blood | LUZP1 | 0.01 | 0.00 | blup | 407 | 0.01 | 1.8e-03 | -6.3 | -5.8 | 4.8e-09 | 0.49 | 0.07 | 0.68 | FALSE |
| 29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WNT4 | 0.03 | 0.01 | blup | 72 | 0.02 | 3.8e-05 | -7.3 | -7.7 | 1.8e-14 | 0.10 | 0.00 | 0.99 | TRUE |
| 30 | The Cancer Genome Atlas | Colon Adenocarcinoma | C1orf213 | 0.13 | 0.04 | lasso | 3 | 0.01 | 1.1e-01 | 5.5 | 5.6 | 2.8e-08 | -0.14 | 0.04 | 0.04 | FALSE |
| 31 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF436 | 0.08 | 0.06 | lasso | 2 | 0.05 | 3.1e-06 | 5.1 | 5.3 | 1.3e-07 | -0.10 | 0.97 | 0.00 | FALSE |
| 32 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ZNF436 | 0.20 | 0.20 | lasso | 5 | 0.18 | 1.1e-10 | 5.3 | 6.0 | 1.9e-09 | -0.20 | 1.00 | 0.00 | FALSE |
| 33 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ZNF436 | 0.18 | 0.14 | lasso | 1 | 0.10 | 1.6e-05 | 5.1 | 5.1 | 2.7e-07 | -0.10 | 0.74 | 0.01 | FALSE |
| 34 | The Cancer Genome Atlas | Lung Adenocarcinoma | C1orf213 | 0.08 | 0.06 | lasso | 1 | 0.05 | 1.1e-06 | 5.3 | 5.3 | 1.1e-07 | -0.11 | 0.95 | 0.00 | FALSE |
| 35 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZNF436 | 0.04 | 0.04 | lasso | 2 | 0.04 | 4.3e-05 | 5.5 | 5.6 | 1.9e-08 | -0.13 | 0.67 | 0.01 | FALSE |
| 36 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ZNF436 | 0.08 | 0.00 | blup | 40 | 0.02 | 6.1e-02 | 5.8 | 7.3 | 1.9e-13 | -0.54 | 0.01 | 0.54 | FALSE |
| 37 | The Cancer Genome Atlas | Soft Tissue Sarcoma | TCEA3 | 0.07 | 0.02 | blup | 55 | 0.03 | 5.0e-03 | 6.0 | -7.9 | 2.9e-15 | 0.59 | 0.01 | 0.58 | TRUE |
| 38 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ZNF436 | 0.05 | 0.04 | enet | 6 | 0.05 | 1.1e-04 | 5.5 | 6.7 | 1.6e-11 | -0.30 | 0.24 | 0.11 | FALSE |
| 39 | The Cancer Genome Atlas | Thyroid Carcinoma | TCEA3 | 0.08 | 0.03 | lasso | 5 | 0.06 | 1.3e-06 | 5.5 | -5.6 | 2.7e-08 | 0.34 | 0.90 | 0.06 | FALSE |
| 40 | The Cancer Genome Atlas | Thyroid Carcinoma | WNT4 | 0.14 | 0.06 | blup | 70 | 0.12 | 9.7e-12 | 3.1 | 5.8 | 9.1e-09 | -0.07 | 0.97 | 0.02 | FALSE |