Best TWAS P=1.24e-16 · Best GWAS P=5.46e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | HSPA4 | 0.13 | 0.09 | enet | 22 | 0.09 | 1.5e-09 | -8.1 | -7.4 | 1.4e-13 | 0.85 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Nerve Tibial | HSPA4 | 0.15 | 0.07 | lasso | 3 | 0.05 | 1.0e-04 | -8.0 | -8.3 | 1.2e-16 | 0.96 | 0.01 | 0.98 | TRUE |
| 3 | GTEx | Testis | HSPA4 | 0.13 | 0.13 | lasso | 2 | 0.12 | 9.1e-06 | -8.1 | -8.1 | 6.4e-16 | 1.00 | 0.01 | 0.98 | FALSE |
| 4 | YFS | Blood | HSPA4 | 0.17 | 0.02 | blup | 433 | 0.09 | 2.8e-27 | -8.0 | 5.8 | 4.8e-09 | -0.48 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HSPA4 | 0.03 | 0.02 | blup | 50 | 0.02 | 5.8e-05 | -8.0 | 8.1 | 4.2e-16 | -0.90 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZCCHC10 | 0.03 | 0.02 | blup | 30 | 0.02 | 1.3e-05 | -8.0 | 8.2 | 1.6e-16 | -0.92 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LEAP2 | 0.08 | 0.08 | enet | 4 | 0.09 | 3.7e-10 | -4.8 | -6.1 | 1.0e-09 | 0.43 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SHROOM1 | 0.08 | 0.09 | lasso | 2 | 0.08 | 1.0e-09 | -6.1 | -6.1 | 1.4e-09 | 0.49 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HSPA4 | 0.09 | 0.01 | blup | 50 | 0.05 | 4.1e-06 | -1.5 | -6.0 | 2.6e-09 | 0.63 | 0.02 | 0.77 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | UQCRQ | 0.02 | 0.01 | blup | 33 | 0.01 | 3.2e-02 | -6.1 | 5.4 | 6.5e-08 | -0.44 | 0.00 | 0.85 | FALSE |
| 11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LEAP2 | 0.24 | 0.06 | enet | 9 | 0.07 | 2.1e-03 | -5.9 | -5.6 | 2.8e-08 | 0.44 | 0.01 | 0.78 | FALSE |