Hub : Genes

UQCRQ

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0690 0.0270 0.0012 0.005 0.026 0.013 0.023 0.015 0.066 0.00036 0.0083 0.00074 0.0052
2 GTEx Esophagus Gastroesophageal Junction 0.2050 0.0800 0.0046 0.013 NA 0.035 NA 0.033 0.100 NA 0.0200 NA 0.0230
3 TCGA Lung Adenocarcinoma 0.0224 0.0164 0.0084 0.012 0.008 0.002 NA 0.007 0.013 0.03200 0.1900 NA 0.0430

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.9 2.9 5.7 1.3 1.2 2.4
Bipolar Disorder or Schizophrenia 0.6 1.6 3.2 -0.3 1.8 1.2
Depressed Affect (Nagel 2018) 1.1 2.3 5.8 2.4 -0.5 0.9
Depression (Nagel 2018) 0.1 0.1 0.2 0.2 -0.3 0.4
Intelligence (Savage-Jansen 2018) 0.5 1.6 2.8 1.2 0.6 1.7
Neuroticism (Nagel 2018) 2.0 4.7 12.2 3.5 0.7 1.2
Schizophrenia (2018) 0.6 1.3 2.0 -1.4 1.3 -0.4
Schizophrenia vs Biploar Disorder 1.0 1.3 2.9 0.2 1.0 -1.7
Worry (Nagel 2018) 2.8 6.0 11.8 3.4 2.1 1.3
Alzheimer’s Disease (in mother) 1.6 1.9 4.2 0.4 2.0 -1.2
Alzheimer’s Disease (in father) 0.2 0.3 0.7 0.8 -0.1 -0.3
Alzheimer’s Disease (including proxy) 1.3 1.9 2.9 1.1 1.7 -1.2
Crohns Disease (2017) 13.0 28.5 61.5 -4.4 -7.8 -2.2
Irritable Bowel Disease (IBD) 7.7 18.4 43.4 -3.0 -6.6 -1.6
Ulcerative Colitis (UC) 1.5 2.8 7.3 -0.8 -2.7 -0.6
Major Depression (MDD) 0.6 0.8 2.2 0.2 -0.2 1.5
Reaction Time 1.9 3.7 10.8 3.3 0.2 0.3
Verbal and Numeric Reasoning (VNR) 1.5 3.7 8.1 1.4 0.9 2.9
Breast Cancer 5.7 13.8 31.7 -0.1 5.6 -3.1
Ovarian Cancer 1.2 1.6 3.8 -1.9 -0.2 -1.1
Prostate Cancer 1.8 2.5 4.3 1.7 0.6 2.1
Age at First Birth 0.2 0.3 0.6 0.0 0.5 -0.8
Bipolar Disorder (2011) 1.7 1.7 5.0 -0.0 -0.2 2.2
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 0.5 -0.0 1.0
Coronary Artery Disease (CAD) 1.9 2.3 4.8 -1.1 2.2 -1.0
Crohns Disease (2012) 10.9 17.5 47.2 -2.3 -6.9 -0.1
Mean Putamen Volume 0.1 0.1 0.2 -0.1 -0.5 -0.0
Fasting Glucose 2.2 2.6 4.0 2.0 0.2 2.0
HbA1C 0.4 0.5 1.1 -0.5 -1.1 -0.0
HDL Cholesterol 0.3 0.4 0.9 -1.0 -0.2 -0.5
LDL Cholesterol 2.2 3.4 7.7 -0.7 1.5 -2.8
Lupus 1.2 1.8 4.2 1.0 -0.6 2.0
Neuroticism (2016) 2.0 2.9 4.7 2.2 -0.6 1.9
Primary Biliary Cirrhosis 0.5 0.7 1.8 0.1 -1.3 0.6
Rheumatoid Arthritis 1.0 1.4 3.1 0.3 1.8 1.0
Schizophrenia (2014) 0.7 1.5 2.8 0.9 1.7 1.0
Triglycerides 1.4 2.2 4.1 1.6 0.2 2.0
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.4 -1.2 0.4 1.1
Ulcerative Colitis 2.3 3.3 9.4 -0.7 -3.1 0.1
Blood Eosinophil Count 17.2 132.6 324.0 6.8 18.0 5.2
Blood Platelet Count 4.2 48.9 139.2 2.6 11.8 -1.0
Blood Red Count 0.2 2.4 5.5 0.7 2.3 -1.1
Blood White Count 3.2 23.6 69.7 1.1 8.3 0.1
Heel T-Score 3.0 23.5 60.2 -2.2 2.4 -7.8
BMI 0.3 1.5 3.7 0.9 -0.3 1.9
Height 1.9 36.3 94.4 -2.5 -9.7 -2.9
Waist Hip Ratio (WHR) 2.2 9.8 29.3 -0.2 0.1 5.4
Systolic Blood Pressure 1.3 6.3 14.8 -0.2 2.1 3.8
Smoking Status 1.7 4.0 10.9 1.1 -3.3 0.3
Allergy or Eczema 3.5 9.3 24.6 0.2 5.0 1.8
Cardiovascular Disease 2.8 9.2 15.2 2.0 3.9 2.9
Hypothyroidism (self reported) 0.3 0.8 2.1 -0.4 0.0 -1.5
Respiratory disease 10.9 24.3 65.9 -1.6 8.1 2.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.7 -0.6 1.3 -0.5
Lung FEV1/FVC ratio 8.4 42.8 125.4 -1.1 -11.2 1.3
Lung FVC 3.0 15.4 24.3 3.5 3.1 4.9
Neuroticism 1.0 2.5 4.9 2.2 0.9 1.3
Chronotype (morning person) 0.3 0.6 1.3 -0.6 1.2 -0.3
Hair Pigment 0.2 5.3 7.2 2.7 2.3 1.9
Tanning 0.1 1.1 2.9 -1.7 0.3 -0.7
Hand grip strength (left) 2.7 7.0 12.5 -1.5 -3.5 -2.5
Number of treatments/medications taken 1.8 3.3 7.5 -0.6 2.7 1.4
Average weekly spirits intake 2.4 3.0 5.2 1.4 1.4 2.3
Sensitivity / hurt feelings 1.2 2.1 4.4 2.1 0.5 1.2
Frequency of depressed mood in last 2 weeks 1.0 1.4 2.6 1.6 -0.8 0.9
Hearing difficulty/problems: Yes 1.9 3.0 4.9 -2.2 1.0 -1.7
Relative age of first facial hair 1.0 2.1 4.0 1.6 2.0 -0.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.2 -1.1 -0.5 0.8
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.6 0.9 -0.2 1.3
Ever had hysterectomy (womb removed) 6.1 6.9 14.4 3.8 -0.1 2.5
Systolic blood pressure, automated reading 0.3 0.7 1.5 -0.9 -0.1 1.2
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 4.5 -1.1 -1.1 -2.1
Angina 0.7 0.9 2.6 -1.6 0.3 0.1
Medication for hormone replacement therapy 0.5 0.6 0.9 -0.4 0.9 0.8
Vitamin and mineral supplements 1.0 1.4 2.9 -0.6 1.7 -0.9
Supplements: Zinc 1.2 1.3 1.9 1.4 -1.1 0.9
Medication: Co-codamol 1.3 1.5 3.9 -2.0 -0.6 -0.3
Medication: Metformin 0.2 0.2 0.6 0.1 0.8 -0.3
Diabetes (father) 0.8 1.0 3.0 0.1 -0.2 1.7
Diabetes (mother) 0.8 1.0 2.4 -0.5 1.6 0.6
Severe depression (siblings) 2.8 3.2 7.9 -1.0 -0.8 2.8
Pack years adult smoking proportion 0.9 1.3 3.0 -0.4 -0.9 1.7
Impedance of leg (right) 1.1 5.5 8.3 -1.9 2.1 -2.9
Leg fat-free mass (left) 1.5 7.9 22.1 0.8 -4.7 1.0
Trunk fat percentage 0.1 0.5 1.1 -0.5 -1.1 0.4
Hand grip strength (right) 2.7 7.4 11.3 -2.3 -3.4 -2.3
Townsend deprivation index at recruitment 1.1 1.5 3.5 1.9 -0.4 0.9
Current tobacco smoking 0.5 0.8 1.3 1.1 -1.2 0.2
Average weekly fortified wine intake 2.5 2.9 5.2 1.2 1.5 2.3
Maternal smoking around birth 2.0 3.0 4.8 -2.2 -1.8 -0.8
Fed-up feelings 0.5 0.9 2.0 1.4 -0.6 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.1 0.1 -0.3 0.4
Relative age voice broke 1.8 2.7 4.6 1.2 2.1 -1.4
Taking other prescription medications 0.7 1.1 2.2 -0.4 1.5 1.0
Age when periods started (menarche) 1.6 3.8 6.4 0.5 -2.5 -2.2
Bilateral oophorectomy (both ovaries removed) 3.6 4.2 9.7 1.6 -0.4 3.1
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 4.3 -0.7 -0.1 -2.1
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.7 -0.2 -0.3 1.3
Qualifications: CSEs or equivalent 0.2 0.3 0.7 0.8 0.3 -0.1
Serious illness, injury or assault to yourself 0.5 0.6 1.2 -1.1 0.7 0.1
High blood pressure 1.8 5.0 7.8 0.8 2.8 2.6
Hayfever, allergic rhinitis or eczema 5.8 12.5 31.8 1.4 5.6 1.9
Multivitamins +/- minerals 0.6 0.8 2.2 -0.2 -1.5 0.4
Stomach or abdominal pain in last month 2.1 2.7 4.7 -0.2 -2.2 1.8
Supplements: Glucosamine 0.7 0.9 1.7 -1.3 0.2 1.0
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.4 -0.5 -0.4 -1.6
Medication: Atenolol 0.4 0.5 1.1 -1.0 0.1 0.7
Medication: Levothyroxine sodium 0.2 0.3 0.3 -0.6 -0.5 -0.5
Sitting height 1.0 7.1 21.2 -0.3 -4.6 -0.3
Chronic bronchitis/emphysema (father) 0.2 0.3 0.6 -0.8 0.1 0.5
High blood pressure (mother) 0.7 1.0 1.7 -1.3 1.0 -0.4
Body mass index (BMI) 0.3 1.5 3.1 1.2 -0.0 1.8
Impedance of leg (left) 1.0 4.7 7.3 -1.6 2.7 -2.1
Leg predicted mass (left) 1.5 7.9 21.9 0.8 -4.7 1.0
Trunk fat mass 0.4 1.6 4.5 -0.2 -2.1 0.6
Waist circumference 1.2 4.4 11.2 0.6 -1.3 3.3
Number of incorrect matches in round 1.8 2.9 4.3 -2.1 -0.8 -2.0
Past tobacco smoking 0.2 0.3 0.6 0.1 0.6 0.8
Alcohol usually taken with meals 0.1 0.2 0.4 0.6 -0.0 0.6
Nervous feelings 1.5 2.9 7.2 2.7 1.1 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.1 0.2 -0.2 0.1
Hearing difficulty/problems with background noise 1.1 1.7 5.0 0.0 2.2 0.3
Hair/balding pattern: Pattern 2 0.9 1.2 2.2 0.0 1.2 -1.5
Had menopause 0.1 0.2 0.2 0.3 0.4 -0.5
Had other major operations 0.5 0.6 1.2 0.4 -0.7 1.1
Forced vital capacity (FVC) 1.1 4.2 7.8 1.6 -1.4 2.8
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 5.7 -1.2 0.5 -2.4
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.5 -0.5 0.3 0.7
Qualifications: None of the above 0.6 1.4 3.1 -0.4 -1.8 -0.9
Financial difficulties in last 2 years 0.8 1.1 1.9 1.2 0.1 1.4
Mouth/teeth dental problems 0.8 1.2 1.9 -0.7 1.4 -1.1
Heart attack 0.4 0.6 0.6 -0.7 0.8 -0.7
Allergy 9.0 20.7 60.8 0.8 -7.8 -0.8
Pain all over the body in last month 1.8 2.0 3.8 -1.3 -1.9 0.6
Diabetes (self-reported) 0.2 0.3 0.7 -0.8 0.4 -0.3
Hayfever/allergic rhinitis (self-reported) 2.2 3.0 4.6 0.3 2.0 2.1
Medication: Ramipril 1.3 1.7 4.7 0.4 0.4 2.2
Medication: Simvastatin 0.3 0.4 0.8 -0.9 0.1 0.7
Fluid intelligence score 2.1 4.4 10.8 1.1 1.0 3.3
Illnesses of siblings 2.9 4.0 10.7 1.1 -3.3 -0.5
Neuroticism score 1.1 2.3 6.0 2.5 0.6 0.8
Weight 1.0 4.8 12.2 0.7 -3.5 1.3
Impedance of arm (right) 0.7 3.2 6.1 -2.5 -1.6 -0.9
Arm fat percentage (right) 0.3 1.0 2.4 -0.4 -0.7 1.5
Trunk fat-free mass 1.2 7.0 19.8 0.9 -4.4 0.6
Hip circumference 0.2 0.7 1.2 0.7 -1.1 0.7
Time employed in main current job 0.3 0.3 0.6 0.4 -0.7 -0.5
Alcohol intake versus 10 years previously 4.8 7.1 20.4 0.2 1.0 -4.5
Father’s age at death 1.1 1.5 3.6 -0.8 -1.9 -0.4
Worrier / anxious feelings 1.1 2.0 5.3 2.3 0.8 0.2
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 3.0 1.1 -0.8 1.7
Falls in the last year 0.5 0.6 1.1 -1.1 -0.7 0.6
Hair/balding pattern: Pattern 3 1.1 1.7 3.0 -0.2 -1.7 1.4
Number of live births 1.1 1.5 2.5 -1.6 -1.3 -0.7
Forced expiratory volume in 1-second (FEV1) 2.2 7.4 14.2 1.1 -3.8 2.6
Pulse rate 0.5 0.9 2.2 0.4 -1.5 -0.6
Happiness 0.1 0.1 0.2 -0.2 0.1 -0.4
Noisy workplace 1.3 1.6 4.5 -0.5 2.1 -0.4
Qualifications: A levels/AS levels or equivalent 1.4 3.1 5.5 1.9 0.4 2.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 0.4 -0.2 0.4
Mouth/teeth dental problems: Dentures 0.9 1.5 3.1 0.4 -1.8 1.1
Asthma 13.9 27.4 77.6 -1.8 8.8 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.9 -0.0 1.4 -1.1
Medication: Cholesterol lowering 1.2 1.8 4.4 -0.5 2.1 -0.9
Depression (self-reported) 1.4 1.6 4.7 0.2 0.4 2.2
Medication: Lansoprazole 1.7 1.9 3.1 -1.8 0.5 -1.5
Prospective memory result 0.6 0.7 1.3 -1.1 0.6 -0.7
Lung cancer (father) 1.4 1.6 2.0 -1.4 -0.9 -1.4
Illnesses of mother 2.3 2.8 8.0 -0.1 -2.8 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.7 12.2 1.5 -3.5 2.4
Pulse wave Arterial Stiffness index 0.4 0.5 1.0 -0.3 -0.6 1.0
Impedance of arm (left) 0.5 2.2 3.9 -2.0 -1.4 -0.8
Arm fat mass (right) 0.4 1.7 3.1 0.1 -1.8 1.4
Trunk predicted mass 1.2 6.7 19.3 0.8 -4.4 0.5
Standing height 2.0 19.8 57.6 -1.0 -7.6 -1.0
Length of working week for main job 0.5 0.6 1.0 0.9 -0.1 1.0
Exposure to tobacco smoke at home 1.4 1.6 2.9 -0.1 -1.3 -1.7
Breastfed as a baby 1.4 1.7 4.9 -0.0 -2.2 -0.4
Tense / ‘highly strung’ 1.4 2.3 4.5 1.6 2.1 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 5.2 0.3 -1.4 2.3
Hair/balding pattern: Pattern 4 1.4 3.3 4.7 -2.2 -1.3 1.9
Birth weight of first child 0.3 0.6 1.5 0.5 -1.2 0.4
Peak expiratory flow (PEF) 2.1 4.8 12.2 -1.3 -3.5 0.7
Pulse wave reflection index 2.2 2.7 4.9 1.2 1.3 2.2
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.5 0.5 -0.7 0.4
Loud music exposure frequency 1.3 1.4 2.0 -1.4 0.9 -1.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.4 -1.2 -0.2 0.7
Mouth/teeth dental problems: Bleeding gums 1.9 2.5 5.5 2.3 -0.4 1.3
Blood clot in the leg (DVT) 2.3 3.0 8.8 -3.0 -0.2 -0.3
Medication: Paracetamol 0.5 0.9 1.7 1.3 -0.8 -0.5
Headache pain in last month 2.3 3.9 6.5 1.9 1.2 2.5
Medication for cholesterol, blood pressure or diabetes 1.7 2.9 6.6 1.3 -2.6 0.5
Glaucoma (self-reported) 1.0 1.2 2.1 -1.4 1.0 -0.7
Gout (self-reported) 1.1 1.5 3.0 -0.3 1.2 -1.7
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 3.1 -0.3 -0.6 -1.8
Medication: Amlodipine 2.4 3.3 5.3 0.6 2.1 2.3
Medication: Ventolin 100micrograms inhaler 5.0 6.4 18.4 -0.1 4.3 0.9
Birth weight 2.6 5.7 9.9 -1.3 -3.1 -2.4
Chronic bronchitis/emphysema (mother) 2.7 3.1 8.5 -0.3 2.9 0.9
High blood pressure (siblings) 1.9 2.7 7.6 -0.5 2.8 0.5
Forced vital capacity (FVC), Best measure 0.7 2.7 4.9 1.3 -1.2 2.2
Body fat percentage 0.1 0.2 0.3 -0.4 -0.4 0.6
Leg fat percentage (right) 0.2 0.6 1.5 -0.4 1.2 0.1
Arm fat-free mass (right) 0.8 4.3 11.2 1.2 -3.4 0.4
Exposure to tobacco smoke outside home 3.6 4.8 10.6 -1.6 -1.0 -3.3
Comparative body size at age 10 0.5 1.4 2.2 0.7 1.5 1.3
Number of full brothers 4.2 5.3 13.0 -3.6 -0.4 -1.6
Worry too long after embarrassment 2.2 3.6 7.4 2.7 1.3 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 2.9 -0.1 -1.7 1.4
Wheeze or whistling in the chest in last year 3.9 6.9 12.8 -2.7 3.6 -1.0
Number of children fathered 1.0 1.1 2.4 -1.5 -0.7 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.1 0.4 1.0 0.1
Age at first live birth 1.0 1.8 3.4 0.1 1.4 1.8
Pulse wave peak to peak time 0.2 0.2 0.6 0.1 0.1 -0.8
Health satisfaction 0.2 0.3 0.7 -0.9 0.2 0.3
Shortness of breath walking on level ground 0.6 0.8 1.3 -0.4 -0.9 -1.2
Qualifications: College or University degree 2.4 7.4 17.0 1.5 1.8 4.1
Eye problems/disorders: None of the above 2.9 3.3 7.7 1.4 0.6 2.8
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.6 1.3 -0.1 0.3
Emphysema/chronic bronchitis 1.6 1.8 2.2 -1.5 -1.3 -1.3
Medication for pain relief, constipation, heartburn 0.4 0.6 1.5 -0.5 -1.2 0.5
Neck or shoulder pain in last month 0.9 1.3 2.1 1.5 1.3 0.1
Medication: Blood pressure 1.2 2.1 3.8 -1.6 1.9 0.4
Angina (self-reported) 0.6 0.8 2.4 -1.6 0.1 0.0
Migraine (self-reported) 0.6 0.8 1.2 0.9 0.7 1.1
Medication: Ibuprofen 0.7 0.8 1.4 0.2 1.2 -1.0
Medication: Allopurinol 1.3 1.8 2.7 0.2 1.7 -1.6
Medication: Omeprazole 0.6 0.7 1.1 1.0 0.0 1.1
Medication: Seretide 50 evohaler 4.3 4.9 14.6 -0.3 3.8 -0.3
Mean time to correctly identify matches 0.8 1.5 4.1 2.0 -0.3 0.5
Heart disease (mother) 0.1 0.1 0.1 0.3 0.0 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.4 4.0 8.9 -1.8 -0.3 -3.0
Whole body fat mass 0.3 1.3 3.2 0.0 -1.8 0.8
Leg fat mass (right) 0.1 0.2 0.5 -0.2 -0.7 0.3
Arm predicted mass (right) 0.6 3.3 7.8 1.4 -2.8 0.5
Pulse rate, automated reading 0.6 1.9 3.4 1.3 -0.9 1.8
Alcohol intake frequency. 2.5 5.8 13.5 0.0 2.0 -3.7
Comparative height size at age 10 2.1 11.7 30.2 -2.0 -5.5 0.9
Number of full sisters 0.8 0.9 1.5 0.3 -1.1 1.2
Suffer from ‘nerves’ 0.1 0.2 0.4 0.6 0.3 -0.4
Overall health rating 0.1 0.2 0.4 0.2 0.6 0.5
Chest pain or discomfort 1.4 2.0 5.9 -2.4 -0.1 -0.5
Had major operations 0.3 0.3 0.9 0.1 0.0 0.9
Age at last live birth 0.1 0.2 0.4 -0.6 -0.1 0.4
Family relationship satisfaction 1.1 1.4 3.1 0.9 -0.4 1.8
Leg pain on walking 0.1 0.1 0.2 -0.3 -0.2 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.4 0.4 -0.8 -1.6
Commuting to job workplace: Car/motor vehicle 4.1 4.7 13.5 -3.7 -0.7 -0.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 0.8 0.8 0.9 0.7
Medication: Aspirin 0.5 0.6 1.0 -0.9 1.0 -0.3
Supplements: Vitamin C 6.0 7.1 17.0 4.1 -0.0 2.1
Knee pain experienced in last month 0.5 0.8 2.3 -0.2 0.0 1.5
Hypertension (Self-reported) 1.4 3.8 5.5 0.8 2.3 2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.2 -0.5 0.6 -1.5
Illnesses of father: Heart disease 2.6 3.6 9.7 -0.7 3.1 -0.8
Illnesses of siblings: Diabetes 0.7 0.9 2.3 -0.2 1.5 0.6
Smoking status: Previous 0.3 0.5 1.0 -0.3 -0.5 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 5.0 2.2 -1.6 0.4
Whole body fat-free mass 1.3 7.4 20.7 1.0 -4.5 0.8
Leg fat-free mass (right) 1.6 8.5 21.7 1.1 -4.7 1.6
Arm fat percentage (left) 0.2 0.9 2.4 -0.2 -0.5 1.5
Average weekly red wine intake 3.0 4.4 7.6 2.4 -0.2 2.7
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.8 1.7 -0.5 -0.4
Mood swings 0.9 1.6 3.8 1.9 -0.4 0.9
Loneliness, isolation 0.5 0.7 1.0 1.0 -0.5 0.9
Long-standing illness, disability or infirmity 1.0 1.5 3.5 -1.9 0.7 -0.8
Ever had bowel cancer screening 0.9 1.1 1.8 -0.8 -0.8 1.3
Diabetes diagnosed by doctor 0.7 1.2 1.4 -1.2 1.2 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 1.4 -0.8 0.7 1.2
Friendships satisfaction 0.4 0.5 1.5 0.3 0.2 1.2
Qualifications: nursing, teaching 0.9 1.3 2.7 0.7 1.6 0.9
Commuting to job workplace: Walk 3.9 4.2 9.1 3.0 0.8 1.7
Eye problems/disorders: Cataract 0.3 0.3 0.9 -0.0 -1.0 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.7 -1.3 0.1 0.3
Medication for cholesterol 2.7 4.0 11.9 -0.2 -0.4 -3.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.0 -0.2 -1.4 0.5
Back pain experienced in last month 1.2 1.8 3.0 -0.1 -1.7 1.5
Mineral and other dietary supplements 0.5 0.6 1.2 -0.8 -0.1 -1.1
Breast cancer (self-reported) 1.5 1.8 2.4 1.4 -1.0 1.6
Asthma (self-reported) 14.8 29.5 83.9 -1.9 9.2 1.0
Osteoporosis (self-reported) 0.4 0.5 0.9 1.0 -0.4 0.5
Osteoarthritis (self-reported) 0.4 0.5 1.3 -0.3 -0.1 1.1
Medication: Aspirin 0.2 0.3 0.6 -0.8 0.6 0.0
Medication: Gliclazide 0.2 0.3 0.6 -0.8 -0.4 0.0
Illnesses of father: None of the above (group 1) 0.9 1.1 1.6 0.5 -1.1 -1.3
Smoking status: Current 0.5 0.8 1.4 1.2 -1.0 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 5.3 0.8 -2.3 0.6
Whole body water mass 1.3 7.5 20.9 1.0 -4.6 0.8
Leg predicted mass (right) 1.6 8.4 21.3 1.1 -4.6 1.7
Arm fat mass (left) 0.5 2.0 3.6 0.3 -1.9 1.5
Number of self-reported non-cancer illnesses 4.0 7.0 11.2 -2.0 3.3 2.4
Average weekly champagne plus white wine intake 0.2 0.2 0.6 0.1 -0.4 0.8
Miserableness 0.9 1.5 1.8 1.2 -1.4 1.1
Guilty feelings 0.3 0.5 1.1 -0.2 -0.5 -1.0
Wears glasses or contact lenses 0.8 0.9 2.2 -1.5 -0.6 0.5
Ever taken oral contraceptive pill 1.9 2.2 3.1 -1.5 1.8 -1.1
Hearing aid user 0.9 1.0 2.0 -1.4 1.0 0.3
Mother’s age at death 0.1 0.1 0.2 -0.5 -0.1 -0.3
Financial situation satisfaction 0.7 0.9 1.7 0.1 1.0 -1.3
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 0.3 0.5 -0.2
Commuting to job workplace: Public transport 5.4 6.5 16.0 4.0 1.0 1.6
Eye problems/disorders: Glaucoma 1.0 1.2 1.8 -1.3 0.6 -1.2
Medication: Blood pressure 3.3 6.2 13.8 1.3 1.8 3.7
Pain type(s) experienced in last month: Hip pain 1.9 2.3 5.3 -2.3 -0.5 -1.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.8 0.9 0.4 0.4
High cholesterol (Self-reported) 0.2 0.3 0.5 -0.5 0.7 0.4
Medication: Bendroflumethiazide 2.5 3.8 5.4 1.1 2.2 2.3
Medication: Paracetamol 1.2 1.9 5.7 2.4 -0.2 -0.1
Medication: Lisinopril 1.1 1.4 1.4 -1.1 -1.2 -1.2
Medication: Atorvastatin 0.2 0.2 0.4 -0.0 0.6 0.5
Illnesses of father: High blood pressure 1.2 1.4 2.0 1.0 1.4 1.2
Alcohol drinker status: Never 1.0 1.2 3.1 -0.8 1.8 0.1
Ever smoked 0.1 0.2 0.4 0.4 -0.6 0.1
Basal metabolic rate 1.3 7.4 20.0 1.1 -4.5 1.0
Leg fat percentage (left) 0.2 0.9 2.0 -0.0 1.4 0.7
Arm fat-free mass (left) 1.2 6.0 16.5 1.1 -4.1 0.4
Number of operations (self-reported) 2.4 3.5 6.5 0.6 -2.0 2.5
Average weekly beer plus cider intake 1.3 1.9 4.3 -1.0 -2.1 -0.7
Irritability 0.6 1.0 1.2 1.1 1.1 -0.9
Risk taking 1.1 1.6 4.8 -2.2 -0.1 0.2
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.5 0.6 0.3 -0.7
Fractured/broken bones in last 5 years 0.9 1.2 2.7 0.7 -0.6 1.6
Age started oral contraceptive pill 0.1 0.1 0.2 0.5 0.1 -0.0
Diastolic blood pressure, automated reading 1.5 4.7 7.9 1.6 1.8 2.8
Ever depressed for a whole week 1.3 1.6 4.1 -0.2 0.7 2.0
Unable to work because of sickness or disability 1.3 1.7 2.4 -1.2 -1.1 1.6
Commuting to job workplace: Cycle 0.4 0.5 0.8 0.9 0.2 0.7
Myopia 1.1 1.6 2.0 -1.0 1.4 -1.3
Vascular/heart problems diagnosed by doctor 2.4 6.6 11.3 -0.4 -3.4 -2.9
Cholesterol lowering medication 1.3 1.8 4.5 -0.4 -0.9 2.1
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.4 0.6 0.9 1.6
Pain experienced in last month 1.7 2.8 7.9 -0.5 0.3 -2.8
Supplements: Calcium 0.8 0.8 2.1 -0.6 -1.4 0.3
Basal cell carcinoma (self-reported) 1.5 1.7 3.7 -1.2 -1.9 0.3
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.2 -0.7 1.1 -0.8
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 7.8 -2.8 -0.4 0.1
Heart disease (siblings) 3.2 3.9 6.6 -2.6 0.9 -2.1
Alcohol drinker status: Previous 1.8 2.1 6.0 0.4 -2.5 0.1
Pack years of smoking 1.0 1.5 3.0 -0.6 -1.1 1.7
Impedance of whole body 0.5 2.5 4.7 -2.2 0.3 -1.7
Leg fat mass (left) 0.1 0.2 0.5 0.2 -0.5 0.7
Arm predicted mass (left) 1.1 5.5 15.1 1.0 -3.9 0.6