TWAS hub - UQCRQ

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0690	0.0270	0.0012	0.005	0.026	0.013	0.023	0.015	0.066	0.00036	0.0083	0.00074	0.0052
2	GTEx	Esophagus Gastroesophageal Junction	0.2050	0.0800	0.0046	0.013	NA	0.035	NA	0.033	0.100	NA	0.0200	NA	0.0230
3	TCGA	Lung Adenocarcinoma	0.0224	0.0164	0.0084	0.012	0.008	0.002	NA	0.007	0.013	0.03200	0.1900	NA	0.0430

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Eosinophil Count	17.2	132.6	324.0	6.8	18.0	5.2
Asthma (self-reported)	14.8	29.5	83.9	-1.9	9.2	1.0
Asthma	13.9	27.4	77.6	-1.8	8.8	1.1
Crohns Disease (2017)	13.0	28.5	61.5	-4.4	-7.8	-2.2
Crohns Disease (2012)	10.9	17.5	47.2	-2.3	-6.9	-0.1
Respiratory disease	10.9	24.3	65.9	-1.6	8.1	2.1
Allergy	9.0	20.7	60.8	0.8	-7.8	-0.8
Lung FEV1/FVC ratio	8.4	42.8	125.4	-1.1	-11.2	1.3
Irritable Bowel Disease (IBD)	7.7	18.4	43.4	-3.0	-6.6	-1.6
Ever had hysterectomy (womb removed)	6.1	6.9	14.4	3.8	-0.1	2.5
Supplements: Vitamin C	6.0	7.1	17.0	4.1	-0.0	2.1
Hayfever, allergic rhinitis or eczema	5.8	12.5	31.8	1.4	5.6	1.9
Breast Cancer	5.7	13.8	31.7	-0.1	5.6	-3.1
Commuting to job workplace: Public transport	5.4	6.5	16.0	4.0	1.0	1.6
Medication: Ventolin 100micrograms inhaler	5.0	6.4	18.4	-0.1	4.3	0.9
Alcohol intake versus 10 years previously	4.8	7.1	20.4	0.2	1.0	-4.5
Medication: Seretide 50 evohaler	4.3	4.9	14.6	-0.3	3.8	-0.3
Blood Platelet Count	4.2	48.9	139.2	2.6	11.8	-1.0
Number of full brothers	4.2	5.3	13.0	-3.6	-0.4	-1.6
Commuting to job workplace: Car/motor vehicle	4.1	4.7	13.5	-3.7	-0.7	-0.5
Number of self-reported non-cancer illnesses	4.0	7.0	11.2	-2.0	3.3	2.4
Wheeze or whistling in the chest in last year	3.9	6.9	12.8	-2.7	3.6	-1.0
Commuting to job workplace: Walk	3.9	4.2	9.1	3.0	0.8	1.7
Bilateral oophorectomy (both ovaries removed)	3.6	4.2	9.7	1.6	-0.4	3.1
Exposure to tobacco smoke outside home	3.6	4.8	10.6	-1.6	-1.0	-3.3
Allergy or Eczema	3.5	9.3	24.6	0.2	5.0	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.4	4.0	8.9	-1.8	-0.3	-3.0
Medication: Blood pressure	3.3	6.2	13.8	1.3	1.8	3.7
Blood White Count	3.2	23.6	69.7	1.1	8.3	0.1
Heart disease (siblings)	3.2	3.9	6.6	-2.6	0.9	-2.1
Heel T-Score	3.0	23.5	60.2	-2.2	2.4	-7.8
Lung FVC	3.0	15.4	24.3	3.5	3.1	4.9
Average weekly red wine intake	3.0	4.4	7.6	2.4	-0.2	2.7
Illnesses of siblings	2.9	4.0	10.7	1.1	-3.3	-0.5
Eye problems/disorders: None of the above	2.9	3.3	7.7	1.4	0.6	2.8
Worry (Nagel 2018)	2.8	6.0	11.8	3.4	2.1	1.3
Cardiovascular Disease	2.8	9.2	15.2	2.0	3.9	2.9
Severe depression (siblings)	2.8	3.2	7.9	-1.0	-0.8	2.8
Hand grip strength (left)	2.7	7.0	12.5	-1.5	-3.5	-2.5
Hand grip strength (right)	2.7	7.4	11.3	-2.3	-3.4	-2.3
Chronic bronchitis/emphysema (mother)	2.7	3.1	8.5	-0.3	2.9	0.9
Medication for cholesterol	2.7	4.0	11.9	-0.2	-0.4	-3.5
Birth weight	2.6	5.7	9.9	-1.3	-3.1	-2.4
Illnesses of father: Heart disease	2.6	3.6	9.7	-0.7	3.1	-0.8
Average weekly fortified wine intake	2.5	2.9	5.2	1.2	1.5	2.3
Alcohol intake frequency.	2.5	5.8	13.5	0.0	2.0	-3.7
Medication: Bendroflumethiazide	2.5	3.8	5.4	1.1	2.2	2.3
Average weekly spirits intake	2.4	3.0	5.2	1.4	1.4	2.3
Medication: Amlodipine	2.4	3.3	5.3	0.6	2.1	2.3
Qualifications: College or University degree	2.4	7.4	17.0	1.5	1.8	4.1
Number of operations (self-reported)	2.4	3.5	6.5	0.6	-2.0	2.5
Vascular/heart problems diagnosed by doctor	2.4	6.6	11.3	-0.4	-3.4	-2.9
Ulcerative Colitis	2.3	3.3	9.4	-0.7	-3.1	0.1
Illnesses of mother	2.3	2.8	8.0	-0.1	-2.8	0.6
Blood clot in the leg (DVT)	2.3	3.0	8.8	-3.0	-0.2	-0.3
Headache pain in last month	2.3	3.9	6.5	1.9	1.2	2.5
Fasting Glucose	2.2	2.6	4.0	2.0	0.2	2.0
LDL Cholesterol	2.2	3.4	7.7	-0.7	1.5	-2.8
Waist Hip Ratio (WHR)	2.2	9.8	29.3	-0.2	0.1	5.4
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	4.6	0.3	2.0	2.1
Forced expiratory volume in 1-second (FEV1)	2.2	7.4	14.2	1.1	-3.8	2.6
Pulse wave reflection index	2.2	2.7	4.9	1.2	1.3	2.2
Worry too long after embarrassment	2.2	3.6	7.4	2.7	1.3	1.3
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	4.5	-1.1	-1.1	-2.1
Stomach or abdominal pain in last month	2.1	2.7	4.7	-0.2	-2.2	1.8
Fluid intelligence score	2.1	4.4	10.8	1.1	1.0	3.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	12.2	1.5	-3.5	2.4
Peak expiratory flow (PEF)	2.1	4.8	12.2	-1.3	-3.5	0.7
Comparative height size at age 10	2.1	11.7	30.2	-2.0	-5.5	0.9
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	7.8	-2.8	-0.4	0.1
Neuroticism (Nagel 2018)	2.0	4.7	12.2	3.5	0.7	1.2
Neuroticism (2016)	2.0	2.9	4.7	2.2	-0.6	1.9
Maternal smoking around birth	2.0	3.0	4.8	-2.2	-1.8	-0.8
Standing height	2.0	19.8	57.6	-1.0	-7.6	-1.0
Bipolar Disorder (2018)	1.9	2.9	5.7	1.3	1.2	2.4
Reaction Time	1.9	3.7	10.8	3.3	0.2	0.3
Coronary Artery Disease (CAD)	1.9	2.3	4.8	-1.1	2.2	-1.0
Height	1.9	36.3	94.4	-2.5	-9.7	-2.9
Hearing difficulty/problems: Yes	1.9	3.0	4.9	-2.2	1.0	-1.7
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	5.5	2.3	-0.4	1.3
High blood pressure (siblings)	1.9	2.7	7.6	-0.5	2.8	0.5
Ever taken oral contraceptive pill	1.9	2.2	3.1	-1.5	1.8	-1.1
Pain type(s) experienced in last month: Hip pain	1.9	2.3	5.3	-2.3	-0.5	-1.2
Prostate Cancer	1.8	2.5	4.3	1.7	0.6	2.1
Number of treatments/medications taken	1.8	3.3	7.5	-0.6	2.7	1.4
Relative age voice broke	1.8	2.7	4.6	1.2	2.1	-1.4
High blood pressure	1.8	5.0	7.8	0.8	2.8	2.6
Number of incorrect matches in round	1.8	2.9	4.3	-2.1	-0.8	-2.0
Pain all over the body in last month	1.8	2.0	3.8	-1.3	-1.9	0.6
Alcohol drinker status: Previous	1.8	2.1	6.0	0.4	-2.5	0.1
Bipolar Disorder (2011)	1.7	1.7	5.0	-0.0	-0.2	2.2
Smoking Status	1.7	4.0	10.9	1.1	-3.3	0.3
Medication: Lansoprazole	1.7	1.9	3.1	-1.8	0.5	-1.5
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	6.6	1.3	-2.6	0.5
Pain experienced in last month	1.7	2.8	7.9	-0.5	0.3	-2.8
Alzheimer’s Disease (in mother)	1.6	1.9	4.2	0.4	2.0	-1.2
Age when periods started (menarche)	1.6	3.8	6.4	0.5	-2.5	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	5.2	0.3	-1.4	2.3
Emphysema/chronic bronchitis	1.6	1.8	2.2	-1.5	-1.3	-1.3
Leg fat-free mass (right)	1.6	8.5	21.7	1.1	-4.7	1.6
Leg predicted mass (right)	1.6	8.4	21.3	1.1	-4.6	1.7
Ulcerative Colitis (UC)	1.5	2.8	7.3	-0.8	-2.7	-0.6
Verbal and Numeric Reasoning (VNR)	1.5	3.7	8.1	1.4	0.9	2.9
Leg fat-free mass (left)	1.5	7.9	22.1	0.8	-4.7	1.0
Leg predicted mass (left)	1.5	7.9	21.9	0.8	-4.7	1.0
Nervous feelings	1.5	2.9	7.2	2.7	1.1	0.4
Breast cancer (self-reported)	1.5	1.8	2.4	1.4	-1.0	1.6
Diastolic blood pressure, automated reading	1.5	4.7	7.9	1.6	1.8	2.8
Basal cell carcinoma (self-reported)	1.5	1.7	3.7	-1.2	-1.9	0.3
Triglycerides	1.4	2.2	4.1	1.6	0.2	2.0
Qualifications: A levels/AS levels or equivalent	1.4	3.1	5.5	1.9	0.4	2.3
Depression (self-reported)	1.4	1.6	4.7	0.2	0.4	2.2
Lung cancer (father)	1.4	1.6	2.0	-1.4	-0.9	-1.4
Exposure to tobacco smoke at home	1.4	1.6	2.9	-0.1	-1.3	-1.7
Breastfed as a baby	1.4	1.7	4.9	-0.0	-2.2	-0.4
Tense / ‘highly strung’	1.4	2.3	4.5	1.6	2.1	0.2
Hair/balding pattern: Pattern 4	1.4	3.3	4.7	-2.2	-1.3	1.9
Chest pain or discomfort	1.4	2.0	5.9	-2.4	-0.1	-0.5
Hypertension (Self-reported)	1.4	3.8	5.5	0.8	2.3	2.3
Alzheimer’s Disease (including proxy)	1.3	1.9	2.9	1.1	1.7	-1.2
Systolic Blood Pressure	1.3	6.3	14.8	-0.2	2.1	3.8
Medication: Co-codamol	1.3	1.5	3.9	-2.0	-0.6	-0.3
Medication: Ramipril	1.3	1.7	4.7	0.4	0.4	2.2
Noisy workplace	1.3	1.6	4.5	-0.5	2.1	-0.4
Loud music exposure frequency	1.3	1.4	2.0	-1.4	0.9	-1.3
Medication: Allopurinol	1.3	1.8	2.7	0.2	1.7	-1.6
Whole body fat-free mass	1.3	7.4	20.7	1.0	-4.5	0.8
Whole body water mass	1.3	7.5	20.9	1.0	-4.6	0.8
Basal metabolic rate	1.3	7.4	20.0	1.1	-4.5	1.0
Average weekly beer plus cider intake	1.3	1.9	4.3	-1.0	-2.1	-0.7
Ever depressed for a whole week	1.3	1.6	4.1	-0.2	0.7	2.0
Unable to work because of sickness or disability	1.3	1.7	2.4	-1.2	-1.1	1.6
Cholesterol lowering medication	1.3	1.8	4.5	-0.4	-0.9	2.1
Ovarian Cancer	1.2	1.6	3.8	-1.9	-0.2	-1.1
Lupus	1.2	1.8	4.2	1.0	-0.6	2.0
Sensitivity / hurt feelings	1.2	2.1	4.4	2.1	0.5	1.2
Supplements: Zinc	1.2	1.3	1.9	1.4	-1.1	0.9
Waist circumference	1.2	4.4	11.2	0.6	-1.3	3.3
Trunk fat-free mass	1.2	7.0	19.8	0.9	-4.4	0.6
Medication: Cholesterol lowering	1.2	1.8	4.4	-0.5	2.1	-0.9
Trunk predicted mass	1.2	6.7	19.3	0.8	-4.4	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.9	-0.1	-1.7	1.4
Medication: Blood pressure	1.2	2.1	3.8	-1.6	1.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	5.0	2.2	-1.6	0.4
Back pain experienced in last month	1.2	1.8	3.0	-0.1	-1.7	1.5
Medication: Paracetamol	1.2	1.9	5.7	2.4	-0.2	-0.1
Illnesses of father: High blood pressure	1.2	1.4	2.0	1.0	1.4	1.2
Arm fat-free mass (left)	1.2	6.0	16.5	1.1	-4.1	0.4
Depressed Affect (Nagel 2018)	1.1	2.3	5.8	2.4	-0.5	0.9
Impedance of leg (right)	1.1	5.5	8.3	-1.9	2.1	-2.9
Townsend deprivation index at recruitment	1.1	1.5	3.5	1.9	-0.4	0.9
Hearing difficulty/problems with background noise	1.1	1.7	5.0	0.0	2.2	0.3
Forced vital capacity (FVC)	1.1	4.2	7.8	1.6	-1.4	2.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	5.7	-1.2	0.5	-2.4
Neuroticism score	1.1	2.3	6.0	2.5	0.6	0.8
Father’s age at death	1.1	1.5	3.6	-0.8	-1.9	-0.4
Worrier / anxious feelings	1.1	2.0	5.3	2.3	0.8	0.2
Hair/balding pattern: Pattern 3	1.1	1.7	3.0	-0.2	-1.7	1.4
Number of live births	1.1	1.5	2.5	-1.6	-1.3	-0.7
Gout (self-reported)	1.1	1.5	3.0	-0.3	1.2	-1.7
Family relationship satisfaction	1.1	1.4	3.1	0.9	-0.4	1.8
Medication: Lisinopril	1.1	1.4	1.4	-1.1	-1.2	-1.2
Risk taking	1.1	1.6	4.8	-2.2	-0.1	0.2
Myopia	1.1	1.6	2.0	-1.0	1.4	-1.3
Arm predicted mass (left)	1.1	5.5	15.1	1.0	-3.9	0.6
Schizophrenia vs Biploar Disorder	1.0	1.3	2.9	0.2	1.0	-1.7
Rheumatoid Arthritis	1.0	1.4	3.1	0.3	1.8	1.0
Neuroticism	1.0	2.5	4.9	2.2	0.9	1.3
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.6	1.6	-0.8	0.9
Relative age of first facial hair	1.0	2.1	4.0	1.6	2.0	-0.0
Vitamin and mineral supplements	1.0	1.4	2.9	-0.6	1.7	-0.9
Sitting height	1.0	7.1	21.2	-0.3	-4.6	-0.3
Impedance of leg (left)	1.0	4.7	7.3	-1.6	2.7	-2.1
Weight	1.0	4.8	12.2	0.7	-3.5	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.0	1.1	-0.8	1.7
Glaucoma (self-reported)	1.0	1.2	2.1	-1.4	1.0	-0.7
Number of children fathered	1.0	1.1	2.4	-1.5	-0.7	-0.7
Age at first live birth	1.0	1.8	3.4	0.1	1.4	1.8
Long-standing illness, disability or infirmity	1.0	1.5	3.5	-1.9	0.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	5.3	0.8	-2.3	0.6
Eye problems/disorders: Glaucoma	1.0	1.2	1.8	-1.3	0.6	-1.2
Alcohol drinker status: Never	1.0	1.2	3.1	-0.8	1.8	0.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.4	0.6	0.9	1.6
Pack years of smoking	1.0	1.5	3.0	-0.6	-1.1	1.7
Pack years adult smoking proportion	0.9	1.3	3.0	-0.4	-0.9	1.7
Hair/balding pattern: Pattern 2	0.9	1.2	2.2	0.0	1.2	-1.5
Mouth/teeth dental problems: Dentures	0.9	1.5	3.1	0.4	-1.8	1.1
Neck or shoulder pain in last month	0.9	1.3	2.1	1.5	1.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.4	0.4	-0.8	-1.6
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.8	1.7	-0.5	-0.4
Mood swings	0.9	1.6	3.8	1.9	-0.4	0.9
Ever had bowel cancer screening	0.9	1.1	1.8	-0.8	-0.8	1.3
Qualifications: nursing, teaching	0.9	1.3	2.7	0.7	1.6	0.9
Illnesses of father: None of the above (group 1)	0.9	1.1	1.6	0.5	-1.1	-1.3
Miserableness	0.9	1.5	1.8	1.2	-1.4	1.1
Hearing aid user	0.9	1.0	2.0	-1.4	1.0	0.3
Fractured/broken bones in last 5 years	0.9	1.2	2.7	0.7	-0.6	1.6
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.4	-1.2	0.4	1.1
Diabetes (father)	0.8	1.0	3.0	0.1	-0.2	1.7
Diabetes (mother)	0.8	1.0	2.4	-0.5	1.6	0.6
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.4	-0.5	-0.4	-1.6
Financial difficulties in last 2 years	0.8	1.1	1.9	1.2	0.1	1.4
Mouth/teeth dental problems	0.8	1.2	1.9	-0.7	1.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.9	-0.0	1.4	-1.1
Arm fat-free mass (right)	0.8	4.3	11.2	1.2	-3.4	0.4
Mean time to correctly identify matches	0.8	1.5	4.1	2.0	-0.3	0.5
Number of full sisters	0.8	0.9	1.5	0.3	-1.1	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.2	-0.5	0.6	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.4	-0.8	0.7	1.2
Wears glasses or contact lenses	0.8	0.9	2.2	-1.5	-0.6	0.5
Supplements: Calcium	0.8	0.8	2.1	-0.6	-1.4	0.3
Schizophrenia (2014)	0.7	1.5	2.8	0.9	1.7	1.0
Angina	0.7	0.9	2.6	-1.6	0.3	0.1
Taking other prescription medications	0.7	1.1	2.2	-0.4	1.5	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.3	-0.7	-0.1	-2.1
Supplements: Glucosamine	0.7	0.9	1.7	-1.3	0.2	1.0
High blood pressure (mother)	0.7	1.0	1.7	-1.3	1.0	-0.4
Impedance of arm (right)	0.7	3.2	6.1	-2.5	-1.6	-0.9
Forced vital capacity (FVC), Best measure	0.7	2.7	4.9	1.3	-1.2	2.2
Medication: Ibuprofen	0.7	0.8	1.4	0.2	1.2	-1.0
Illnesses of siblings: Diabetes	0.7	0.9	2.3	-0.2	1.5	0.6
Diabetes diagnosed by doctor	0.7	1.2	1.4	-1.2	1.2	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.0	-0.2	-1.4	0.5
Financial situation satisfaction	0.7	0.9	1.7	0.1	1.0	-1.3
Bipolar Disorder or Schizophrenia	0.6	1.6	3.2	-0.3	1.8	1.2
Schizophrenia (2018)	0.6	1.3	2.0	-1.4	1.3	-0.4
Major Depression (MDD)	0.6	0.8	2.2	0.2	-0.2	1.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.6	0.9	-0.2	1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.7	-0.2	-0.3	1.3
Multivitamins +/- minerals	0.6	0.8	2.2	-0.2	-1.5	0.4
Qualifications: None of the above	0.6	1.4	3.1	-0.4	-1.8	-0.9
Prospective memory result	0.6	0.7	1.3	-1.1	0.6	-0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.1	-0.3	-0.6	-1.8
Shortness of breath walking on level ground	0.6	0.8	1.3	-0.4	-0.9	-1.2
Angina (self-reported)	0.6	0.8	2.4	-1.6	0.1	0.0
Migraine (self-reported)	0.6	0.8	1.2	0.9	0.7	1.1
Medication: Omeprazole	0.6	0.7	1.1	1.0	0.0	1.1
Arm predicted mass (right)	0.6	3.3	7.8	1.4	-2.8	0.5
Pulse rate, automated reading	0.6	1.9	3.4	1.3	-0.9	1.8
Irritability	0.6	1.0	1.2	1.1	1.1	-0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.2	-0.7	1.1	-0.8
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.8	1.2	0.6	1.7
Primary Biliary Cirrhosis	0.5	0.7	1.8	0.1	-1.3	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.2	-1.1	-0.5	0.8
Medication for hormone replacement therapy	0.5	0.6	0.9	-0.4	0.9	0.8
Current tobacco smoking	0.5	0.8	1.3	1.1	-1.2	0.2
Fed-up feelings	0.5	0.9	2.0	1.4	-0.6	-0.5
Serious illness, injury or assault to yourself	0.5	0.6	1.2	-1.1	0.7	0.1
Had other major operations	0.5	0.6	1.2	0.4	-0.7	1.1
Falls in the last year	0.5	0.6	1.1	-1.1	-0.7	0.6
Pulse rate	0.5	0.9	2.2	0.4	-1.5	-0.6
Impedance of arm (left)	0.5	2.2	3.9	-2.0	-1.4	-0.8
Length of working week for main job	0.5	0.6	1.0	0.9	-0.1	1.0
Medication: Paracetamol	0.5	0.9	1.7	1.3	-0.8	-0.5
Comparative body size at age 10	0.5	1.4	2.2	0.7	1.5	1.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	1.3	-0.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	0.8	0.9	0.7
Medication: Aspirin	0.5	0.6	1.0	-0.9	1.0	-0.3
Knee pain experienced in last month	0.5	0.8	2.3	-0.2	0.0	1.5
Loneliness, isolation	0.5	0.7	1.0	1.0	-0.5	0.9
Mineral and other dietary supplements	0.5	0.6	1.2	-0.8	-0.1	-1.1
Smoking status: Current	0.5	0.8	1.4	1.2	-1.0	0.1
Arm fat mass (left)	0.5	2.0	3.6	0.3	-1.9	1.5
Impedance of whole body	0.5	2.5	4.7	-2.2	0.3	-1.7
HbA1C	0.4	0.5	1.1	-0.5	-1.1	-0.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.7	-0.6	1.3	-0.5
Medication: Atenolol	0.4	0.5	1.1	-1.0	0.1	0.7
Trunk fat mass	0.4	1.6	4.5	-0.2	-2.1	0.6
Heart attack	0.4	0.6	0.6	-0.7	0.8	-0.7
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	-0.3	-0.6	1.0
Arm fat mass (right)	0.4	1.7	3.1	0.1	-1.8	1.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.4	-1.2	-0.2	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.1	0.4	1.0	0.1
Medication for pain relief, constipation, heartburn	0.4	0.6	1.5	-0.5	-1.2	0.5
Friendships satisfaction	0.4	0.5	1.5	0.3	0.2	1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	-1.3	0.1	0.3
Osteoporosis (self-reported)	0.4	0.5	0.9	1.0	-0.4	0.5
Osteoarthritis (self-reported)	0.4	0.5	1.3	-0.3	-0.1	1.1
Commuting to job workplace: Cycle	0.4	0.5	0.8	0.9	0.2	0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.5	-0.0	1.0
HDL Cholesterol	0.3	0.4	0.9	-1.0	-0.2	-0.5
BMI	0.3	1.5	3.7	0.9	-0.3	1.9
Hypothyroidism (self reported)	0.3	0.8	2.1	-0.4	0.0	-1.5
Chronotype (morning person)	0.3	0.6	1.3	-0.6	1.2	-0.3
Systolic blood pressure, automated reading	0.3	0.7	1.5	-0.9	-0.1	1.2
Body mass index (BMI)	0.3	1.5	3.1	1.2	-0.0	1.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	-0.5	0.3	0.7
Medication: Simvastatin	0.3	0.4	0.8	-0.9	0.1	0.7
Arm fat percentage (right)	0.3	1.0	2.4	-0.4	-0.7	1.5
Time employed in main current job	0.3	0.3	0.6	0.4	-0.7	-0.5
Birth weight of first child	0.3	0.6	1.5	0.5	-1.2	0.4
Whole body fat mass	0.3	1.3	3.2	0.0	-1.8	0.8
Had major operations	0.3	0.3	0.9	0.1	0.0	0.9
Smoking status: Previous	0.3	0.5	1.0	-0.3	-0.5	-1.0
Eye problems/disorders: Cataract	0.3	0.3	0.9	-0.0	-1.0	-0.1
Guilty feelings	0.3	0.5	1.1	-0.2	-0.5	-1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	0.9	0.4	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	0.6	0.3	-0.7
Alzheimer’s Disease (in father)	0.2	0.3	0.7	0.8	-0.1	-0.3
Age at First Birth	0.2	0.3	0.6	0.0	0.5	-0.8
Blood Red Count	0.2	2.4	5.5	0.7	2.3	-1.1
Hair Pigment	0.2	5.3	7.2	2.7	2.3	1.9
Medication: Metformin	0.2	0.2	0.6	0.1	0.8	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.7	0.8	0.3	-0.1
Medication: Levothyroxine sodium	0.2	0.3	0.3	-0.6	-0.5	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.8	0.1	0.5
Past tobacco smoking	0.2	0.3	0.6	0.1	0.6	0.8
Diabetes (self-reported)	0.2	0.3	0.7	-0.8	0.4	-0.3
Hip circumference	0.2	0.7	1.2	0.7	-1.1	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	0.5	-0.7	0.4
Leg fat percentage (right)	0.2	0.6	1.5	-0.4	1.2	0.1
Pulse wave peak to peak time	0.2	0.2	0.6	0.1	0.1	-0.8
Health satisfaction	0.2	0.3	0.7	-0.9	0.2	0.3
Arm fat percentage (left)	0.2	0.9	2.4	-0.2	-0.5	1.5
Medication: Aspirin	0.2	0.3	0.6	-0.8	0.6	0.0
Medication: Gliclazide	0.2	0.3	0.6	-0.8	-0.4	0.0
Average weekly champagne plus white wine intake	0.2	0.2	0.6	0.1	-0.4	0.8
High cholesterol (Self-reported)	0.2	0.3	0.5	-0.5	0.7	0.4
Medication: Atorvastatin	0.2	0.2	0.4	-0.0	0.6	0.5
Leg fat percentage (left)	0.2	0.9	2.0	-0.0	1.4	0.7
Depression (Nagel 2018)	0.1	0.1	0.2	0.2	-0.3	0.4
Mean Putamen Volume	0.1	0.1	0.2	-0.1	-0.5	-0.0
Tanning	0.1	1.1	2.9	-1.7	0.3	-0.7
Trunk fat percentage	0.1	0.5	1.1	-0.5	-1.1	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	0.1	-0.3	0.4
Alcohol usually taken with meals	0.1	0.2	0.4	0.6	-0.0	0.6
Had menopause	0.1	0.2	0.2	0.3	0.4	-0.5
Happiness	0.1	0.1	0.2	-0.2	0.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.4	-0.2	0.4
Body fat percentage	0.1	0.2	0.3	-0.4	-0.4	0.6
Heart disease (mother)	0.1	0.1	0.1	0.3	0.0	0.4
Leg fat mass (right)	0.1	0.2	0.5	-0.2	-0.7	0.3
Suffer from ‘nerves’	0.1	0.2	0.4	0.6	0.3	-0.4
Overall health rating	0.1	0.2	0.4	0.2	0.6	0.5
Age at last live birth	0.1	0.2	0.4	-0.6	-0.1	0.4
Leg pain on walking	0.1	0.1	0.2	-0.3	-0.2	-0.5
Mother’s age at death	0.1	0.1	0.2	-0.5	-0.1	-0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.3	0.5	-0.2
Ever smoked	0.1	0.2	0.4	0.4	-0.6	0.1
Age started oral contraceptive pill	0.1	0.1	0.2	0.5	0.1	-0.0
Leg fat mass (left)	0.1	0.2	0.5	0.2	-0.5	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.2	-0.2	0.1

Hub : Genes

UQCRQ

Models

Trait associations