TWAS hub - LEAP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0768	0.0364	1.1e-08	0.076	0.085	0.088	NA	0.087	7.0e-09	7.8e-10	3.7e-10	NA	5.4e-10
2	TCGA	Testicular Germ Cell Tumors	0.2410	0.1240	1.1e-03	0.065	0.042	0.068	NA	0.057	2.6e-03	1.3e-02	2.1e-03	NA	4.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Alcohol intake versus 10 years previously	16.7	25.0	29.7	5.5	4.5
Heel T-Score	8.2	65.0	74.8	8.7	7.4
Alcohol intake frequency.	8.1	18.8	27.7	5.3	3.2
Waist Hip Ratio (WHR)	7.6	34.1	37.2	-6.1	-5.6
Bilateral oophorectomy (both ovaries removed)	6.6	7.6	9.8	-3.1	-2.3
Medication for cholesterol	6.4	9.8	11.7	2.8	3.4
Average weekly fortified wine intake	6.3	7.4	12.1	-3.5	-1.6
Bipolar Disorder (2011)	5.1	4.9	7.8	-2.8	-1.4
Exposure to tobacco smoke outside home	5.0	6.7	8.3	2.9	2.3
Schizophrenia vs Biploar Disorder	4.8	6.3	8.7	2.9	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.8	5.7	7.7	2.8	1.9
Cholesterol lowering medication	4.8	7.1	10.0	-3.2	-2.1
Bipolar Disorder (2018)	4.7	7.4	12.5	-3.5	-1.5
Severe depression (siblings)	4.7	5.3	7.0	-1.9	-2.6
Eye problems/disorders: None of the above	4.7	5.4	7.3	-2.7	-1.9
Medication: Blood pressure	4.5	8.5	9.4	-2.8	-3.1
Pain experienced in last month	4.3	7.1	7.5	2.6	2.7
Lung FVC	4.1	20.7	34.5	-5.9	-2.6
Qualifications: College or University degree	4.1	12.8	18.5	-4.3	-2.7
Average weekly spirits intake	3.9	4.8	7.4	-2.7	-1.5
Ever had hysterectomy (womb removed)	3.7	4.2	5.6	-2.4	-1.7
Breast Cancer	3.5	8.4	11.6	3.4	2.3
Medication: Amlodipine	3.5	4.8	6.1	-2.5	-1.9
Fluid intelligence score	3.3	6.9	7.4	-2.7	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	3.2	7.4	11.2	3.3	1.9
Fractured/broken bones in last 5 years	3.2	4.1	7.3	-2.7	-0.9
Systolic Blood Pressure	3.1	15.4	16.3	-3.8	-4.0
Number of operations (self-reported)	3.0	4.4	6.6	-2.6	-1.5
Pack years of smoking	3.0	4.3	5.3	-2.3	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.4	17.1	-4.1	-1.3
Average weekly red wine intake	2.8	4.2	6.0	-2.4	-1.6
LDL Cholesterol	2.7	4.3	5.0	2.2	1.9
Pack years adult smoking proportion	2.7	4.1	5.2	-2.3	-1.7
Pulse wave reflection index	2.7	3.3	4.5	-1.5	-2.1
Supplements: Vitamin C	2.7	3.2	6.1	-2.5	-0.5
Lupus	2.6	3.9	4.2	-2.1	-1.9
Hair/balding pattern: Pattern 4	2.6	6.2	6.8	-2.6	-2.4
Stomach or abdominal pain in last month	2.5	3.1	4.5	-1.3	-2.1
Exposure to tobacco smoke at home	2.5	2.8	5.6	-0.1	2.4
Loud music exposure frequency	2.5	2.7	4.7	2.2	0.9
Headache pain in last month	2.5	4.4	4.5	-2.1	-2.1
Illnesses of father: None of the above (group 1)	2.5	3.1	4.5	2.1	1.3
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.5	8.0	2.8	1.7
Diverticular disease/diverticulitis (self-reported)	2.4	2.8	4.8	0.9	2.2
Wears glasses or contact lenses	2.4	2.8	5.5	-0.3	-2.3
Eye problems/disorders: Diabetes related eye disease	2.3	2.6	4.3	0.9	2.1
Waist circumference	2.3	8.5	9.5	-2.8	-3.1
Forced expiratory volume in 1-second (FEV1)	2.3	7.9	12.7	-3.6	-1.8
Pulse wave Arterial Stiffness index	2.3	2.7	3.8	-1.3	-2.0
Ever depressed for a whole week	2.3	2.8	2.9	-1.7	-1.6
Vascular/heart problems diagnosed by doctor	2.3	6.4	8.2	2.1	2.9
Age at first live birth	2.2	3.9	4.6	-1.8	-2.1
Number of self-reported non-cancer illnesses	2.2	3.8	7.6	-0.0	-2.8
Diastolic blood pressure, automated reading	2.2	7.0	9.0	-3.0	-2.2
Fasting Glucose	2.1	2.6	4.3	-2.1	-0.9
Forced vital capacity (FVC)	2.1	7.9	13.1	-3.6	-1.6
Medication: Ramipril	2.1	2.7	3.0	-1.7	-1.5
Forced vital capacity (FVC), Best measure	2.1	7.5	13.8	-3.7	-1.1
Birth weight	2.0	4.3	5.5	1.8	2.3
Medication: Bendroflumethiazide	2.0	3.0	3.5	-1.6	-1.9
Myopia	2.0	3.0	5.0	2.2	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	3.3	-1.8	-1.7
Unable to work because of sickness or disability	1.9	2.4	3.3	-1.2	-1.8
Prostate Cancer	1.8	2.5	4.2	-0.8	-2.1
High blood pressure	1.8	5.1	6.4	-2.0	-2.5
Pain all over the body in last month	1.8	2.0	3.7	0.5	-1.9
Risk taking	1.8	2.6	4.5	2.1	-0.9
Cardiovascular Disease	1.7	5.5	8.3	-2.9	-1.7
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	4.2	-2.0	-0.5
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.4	-0.4	-1.9
Wheeze or whistling in the chest in last year	1.7	3.1	6.2	2.5	0.1
Knee pain experienced in last month	1.7	2.7	3.5	-1.4	-1.9
Relative age voice broke	1.6	2.5	3.1	1.8	1.4
Pulse wave peak to peak time	1.6	1.9	3.1	0.9	1.7
Alzheimer’s Disease (in mother)	1.5	1.7	2.9	1.7	0.7
Number of treatments/medications taken	1.5	2.6	4.3	-1.0	-2.1
Relative age of first facial hair	1.5	3.0	5.0	2.2	1.0
Hair/balding pattern: Pattern 2	1.5	2.0	3.3	1.8	0.8
Allergy	1.5	3.4	6.4	-2.5	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	3.5	-1.0	-1.9
Shortness of breath walking on level ground	1.5	1.8	2.9	0.8	1.7
Hearing difficulty/problems: Yes	1.4	2.1	4.3	2.1	0.0
Diabetes (father)	1.4	1.7	2.8	-0.8	-1.7
Age when periods started (menarche)	1.4	3.3	6.3	0.6	2.5
Asthma	1.4	2.8	4.5	2.1	-1.1
Worry too long after embarrassment	1.4	2.3	4.6	-2.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.7	0.9	1.6
Hypertension (Self-reported)	1.4	3.8	4.2	-1.9	-2.0
Hearing aid user	1.4	1.5	1.7	1.2	-1.3
Verbal and Numeric Reasoning (VNR)	1.3	3.2	3.7	-1.6	-1.9
Lung FEV1/FVC ratio	1.3	6.4	8.5	-2.9	-2.1
Depression (self-reported)	1.3	1.5	2.3	-0.9	-1.5
Number of full brothers	1.3	1.7	3.3	1.8	0.2
Pulse rate, automated reading	1.3	4.1	5.0	-2.2	-1.8
Smoking status: Previous	1.3	1.9	2.5	1.6	1.2
Asthma (self-reported)	1.3	2.6	4.0	2.0	-1.1
Illnesses of father: High blood pressure	1.3	1.6	3.0	-1.7	-0.6
Irritability	1.3	2.2	3.6	1.0	1.9
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.8	-0.3	-1.7
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.3	-1.5	-0.9
Impedance of leg (right)	1.2	5.7	6.3	2.5	2.3
Medication: Simvastatin	1.2	1.8	2.2	-1.5	-1.2
Qualifications: A levels/AS levels or equivalent	1.2	2.7	4.3	-2.1	-1.1
Medication: Lansoprazole	1.2	1.4	2.6	1.6	0.5
Lung cancer (father)	1.2	1.4	2.1	1.4	0.9
Medication: Seretide 50 evohaler	1.2	1.4	2.8	1.7	0.3
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.5	1.6	0.6
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.2	-0.9	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.9	0.4	-1.7
Migraine (self-reported)	1.1	1.4	2.4	-0.7	-1.5
Family relationship satisfaction	1.1	1.4	1.9	-0.9	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.2	1.5	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.5	-0.9	-1.2
Back pain experienced in last month	1.1	1.6	2.4	-0.9	-1.5
Medication: Gliclazide	1.1	1.2	2.4	-1.6	-0.0
Alzheimer’s Disease (including proxy)	1.0	1.5	2.0	1.4	1.0
Respiratory disease	1.0	2.1	3.3	1.0	-1.8
Systolic blood pressure, automated reading	1.0	3.0	4.0	-1.4	-2.0
Chronic bronchitis/emphysema (father)	1.0	1.2	2.5	0.0	-1.6
Number of incorrect matches in round	1.0	1.6	1.9	1.4	1.2
Had other major operations	1.0	1.2	1.3	-1.1	-1.2
Gout (self-reported)	1.0	1.4	1.8	1.3	1.0
Commuting to job workplace: Walk	1.0	1.1	1.3	-1.2	-0.9
Osteoarthritis (self-reported)	1.0	1.3	1.3	-1.2	-1.1
Heart disease (siblings)	1.0	1.3	2.1	1.4	0.6
Triglycerides	0.9	1.4	1.5	-1.2	-1.2
Financial difficulties in last 2 years	0.9	1.2	1.3	-1.1	-1.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.3	-1.1	-1.0
Blood clot in the leg (DVT)	0.9	1.1	2.0	0.5	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	1.4	-1.0	-1.2
Number of full sisters	0.9	1.1	1.2	-1.0	-1.1
Ever had bowel cancer screening	0.9	1.1	1.5	-0.8	-1.2
Mineral and other dietary supplements	0.9	1.2	2.4	1.6	0.1
Commuting to job workplace: Public transport	0.9	1.0	2.0	-1.4	-0.2
High cholesterol (Self-reported)	0.9	1.6	3.0	-1.7	-0.5
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.4	-0.9	1.2
Commuting to job workplace: Cycle	0.9	1.1	2.0	-1.4	-0.4
Major Depression (MDD)	0.8	1.0	1.8	-1.3	-0.4
Blood Platelet Count	0.8	9.4	14.1	3.8	2.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.1	-1.0	-1.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.1	-0.9	-1.1
Age at last live birth	0.8	1.1	1.6	-0.8	-1.3
Breast cancer (self-reported)	0.8	1.0	1.3	-1.2	-0.8
Medication: Atorvastatin	0.8	1.0	1.4	-1.2	-0.7
Bipolar Disorder or Schizophrenia	0.7	1.6	1.6	-1.3	-1.3
Reaction Time	0.7	1.4	2.0	-1.4	0.9
Age at First Birth	0.7	1.0	1.7	-0.5	1.3
Vitamin and mineral supplements	0.7	0.9	1.6	1.3	0.5
Supplements: Zinc	0.7	0.8	1.5	-1.2	-0.1
Impedance of leg (left)	0.7	3.5	4.0	2.0	1.7
Past tobacco smoking	0.7	1.3	1.7	-1.3	-1.0
Alcohol usually taken with meals	0.7	1.1	2.2	-1.5	-0.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.5	2.4	1.6	0.7
Medication: Blood pressure	0.7	1.2	2.4	0.0	-1.6
Medication: Allopurinol	0.7	1.0	1.5	0.7	1.2
Medication: Omeprazole	0.7	0.8	0.9	-0.9	-0.9
Illnesses of father: Heart disease	0.7	1.0	1.9	0.1	1.4
Ever taken oral contraceptive pill	0.7	0.7	1.4	1.2	0.3
Financial situation satisfaction	0.7	0.8	1.4	0.5	1.2
Eye problems/disorders: Glaucoma	0.7	0.9	1.6	1.2	0.4
Basal cell carcinoma (self-reported)	0.7	0.8	0.8	-0.9	-0.9
Ovarian Cancer	0.6	0.8	1.0	1.0	0.8
Allergy or Eczema	0.6	1.5	1.6	1.2	-1.3
Hand grip strength (left)	0.6	1.7	2.9	0.7	1.7
Taking other prescription medications	0.6	1.0	1.9	0.1	-1.4
Father’s age at death	0.6	0.8	1.6	-1.3	0.1
Illnesses of mother	0.6	0.7	1.2	-1.1	-0.4
Tense / ‘highly strung’	0.6	0.9	1.9	-0.1	1.4
Emphysema/chronic bronchitis	0.6	0.7	1.2	1.1	0.5
Leg fat-free mass (right)	0.6	3.3	5.5	-2.4	-1.1
Friendships satisfaction	0.6	0.8	1.1	-1.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.1	0.9	-1.1
Leg predicted mass (right)	0.6	3.4	5.6	-2.4	-1.1
Average weekly champagne plus white wine intake	0.6	0.8	0.8	-0.9	-0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.7	0.8	0.9	0.8
Depression (Nagel 2018)	0.5	0.8	1.3	-1.2	-0.5
Sensitivity / hurt feelings	0.5	0.8	1.4	-1.2	-0.4
Diabetes (mother)	0.5	0.7	1.0	-1.0	-0.6
Maternal smoking around birth	0.5	0.7	1.3	1.2	-0.2
Supplements: Glucosamine	0.5	0.7	1.0	-1.0	-0.7
Medication: Atenolol	0.5	0.6	1.2	-0.0	-1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	-0.4	-1.0
Qualifications: None of the above	0.5	1.0	1.5	1.2	0.7
Heart attack	0.5	0.6	0.6	0.8	0.8
Arm fat percentage (right)	0.5	1.8	3.1	-0.8	-1.7
Hair/balding pattern: Pattern 3	0.5	0.7	1.0	-1.0	-0.6
Length of working week for main job	0.5	0.6	1.1	-1.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.3	-0.5	-1.1
High blood pressure (siblings)	0.5	0.7	1.2	-0.3	-1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-0.9	0.6
Comparative height size at age 10	0.5	2.6	3.8	-1.9	-1.2
Osteoporosis (self-reported)	0.5	0.6	1.2	-1.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.0	-1.4	-0.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.0	-1.0	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.7	-1.3	-0.8
Schizophrenia (2018)	0.4	0.8	1.5	1.2	-0.4
Ulcerative Colitis (UC)	0.4	0.7	1.4	-0.0	1.2
Hypothyroidism (self reported)	0.4	1.0	1.4	1.2	0.8
Hand grip strength (right)	0.4	1.1	1.6	0.8	1.3
Fed-up feelings	0.4	0.8	1.5	0.2	1.2
Leg predicted mass (left)	0.4	2.0	3.5	-1.9	-0.6
Nervous feelings	0.4	0.7	1.2	0.5	1.1
Hearing difficulty/problems with background noise	0.4	0.6	1.1	0.3	-1.0
Illnesses of siblings	0.4	0.6	1.3	0.0	1.1
Noisy workplace	0.4	0.5	1.0	1.0	-0.1
Arm fat mass (right)	0.4	1.5	1.9	-1.1	-1.4
Peak expiratory flow (PEF)	0.4	0.9	1.3	-1.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.8	-0.9	0.7
Glaucoma (self-reported)	0.4	0.5	1.0	1.0	-0.1
Had major operations	0.4	0.5	1.0	-1.0	-0.3
Arm fat percentage (left)	0.4	1.8	2.9	-0.8	-1.7
Qualifications: nursing, teaching	0.4	0.7	0.9	-1.0	-0.6
Eye problems/disorders: Cataract	0.4	0.5	0.9	1.0	0.1
Arm fat mass (left)	0.4	1.5	1.9	-1.1	-1.4
Guilty feelings	0.4	0.6	0.6	0.7	0.8
Neuroticism (Nagel 2018)	0.3	0.6	1.1	-1.0	0.4
Crohns Disease (2017)	0.3	0.6	1.1	1.1	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.3	-0.8
Blood Eosinophil Count	0.3	2.7	2.8	-1.6	-1.7
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.8	-0.9	-0.3
Angina	0.3	0.4	0.6	0.3	-0.8
Medication for hormone replacement therapy	0.3	0.3	0.5	-0.4	-0.7
Leg fat-free mass (left)	0.3	1.8	3.2	-1.8	-0.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.0	0.5	-1.0
Time employed in main current job	0.3	0.4	0.6	0.3	0.8
Worrier / anxious feelings	0.3	0.6	0.9	-0.6	0.9
Falls in the last year	0.3	0.4	0.8	0.0	-0.9
Happiness	0.3	0.3	0.6	0.8	-0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	-1.0	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	-0.4	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.5	0.6	-0.7
Medication: Ibuprofen	0.3	0.4	0.6	-0.4	0.8
Mean time to correctly identify matches	0.3	0.6	1.3	-1.1	0.2
Chest pain or discomfort	0.3	0.4	0.5	0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	-1.1	-0.0
Medication: Paracetamol	0.3	0.4	0.6	-0.8	0.5
Alcohol drinker status: Never	0.3	0.3	0.3	0.6	-0.5
Worry (Nagel 2018)	0.2	0.3	0.5	-0.7	0.4
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	0.3	0.8
Crohns Disease (2012)	0.2	0.2	0.4	-0.2	-0.7
HbA1C	0.2	0.2	0.5	0.1	-0.7
Neuroticism (2016)	0.2	0.4	0.7	-0.8	-0.2
Rheumatoid Arthritis	0.2	0.3	0.5	0.3	-0.7
Schizophrenia (2014)	0.2	0.4	0.4	-0.7	-0.6
Blood White Count	0.2	1.8	2.0	1.4	1.3
BMI	0.2	1.0	2.1	-0.0	-1.4
Height	0.2	3.3	5.5	-1.0	2.4
Neuroticism	0.2	0.5	0.9	-1.0	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.7	-0.3
High blood pressure (mother)	0.2	0.3	0.6	0.8	0.0
Body mass index (BMI)	0.2	0.9	1.4	-0.6	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.4	-0.3	0.6
Mouth/teeth dental problems	0.2	0.3	0.4	0.5	0.6
Neuroticism score	0.2	0.4	0.6	-0.4	0.8
Weight	0.2	1.0	1.4	-1.2	-0.8
Medication: Cholesterol lowering	0.2	0.4	0.6	0.8	0.4
Prospective memory result	0.2	0.2	0.4	-0.0	0.6
Comparative body size at age 10	0.2	0.6	0.8	-0.9	-0.7
Number of children fathered	0.2	0.2	0.3	0.6	-0.2
Neck or shoulder pain in last month	0.2	0.3	0.4	-0.7	0.4
Angina (self-reported)	0.2	0.3	0.5	0.3	-0.7
Suffer from ‘nerves’	0.2	0.2	0.2	0.5	0.5
Overall health rating	0.2	0.3	0.4	0.7	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.1	-0.7
Miserableness	0.2	0.3	0.4	0.6	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.3	0.6	0.5
Medication: Lisinopril	0.2	0.2	0.3	0.6	0.3
Basal metabolic rate	0.2	0.9	1.7	-1.3	-0.3
Supplements: Calcium	0.2	0.2	0.3	0.3	-0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.2	-0.4	0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	0.3
Ulcerative Colitis	0.1	0.1	0.2	-0.3	0.4
Blood Red Count	0.1	1.0	1.8	0.3	1.3
Smoking Status	0.1	0.3	0.5	0.7	-0.2
Chronotype (morning person)	0.1	0.2	0.4	0.7	0.2
Hair Pigment	0.1	2.0	3.5	-1.9	-0.6
Medication: Metformin	0.1	0.2	0.3	-0.6	-0.1
Trunk fat percentage	0.1	0.3	0.3	-0.5	-0.6
Qualifications: CSEs or equivalent	0.1	0.2	0.3	0.6	-0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.2	-0.5	-0.4
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.5	0.1
Trunk fat mass	0.1	0.4	0.4	-0.7	-0.6
Had menopause	0.1	0.1	0.2	0.4	-0.1
Diabetes (self-reported)	0.1	0.1	0.1	-0.4	-0.3
Impedance of arm (right)	0.1	0.3	0.3	-0.5	-0.6
Trunk fat-free mass	0.1	0.3	0.6	-0.8	0.2
Pulse rate	0.1	0.2	0.2	-0.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.2	-0.4
Impedance of arm (left)	0.1	0.3	0.4	-0.6	-0.5
Standing height	0.1	1.0	1.3	-1.1	0.8
Breastfed as a baby	0.1	0.1	0.2	-0.3	0.4
Birth weight of first child	0.1	0.1	0.2	-0.3	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.4	-0.4
Medication: Paracetamol	0.1	0.2	0.3	-0.5	0.3
Body fat percentage	0.1	0.2	0.5	-0.1	-0.7
Leg fat percentage (right)	0.1	0.5	0.9	1.0	-0.2
Arm fat-free mass (right)	0.1	0.3	0.4	-0.6	0.6
Health satisfaction	0.1	0.2	0.4	-0.6	0.0
Heart disease (mother)	0.1	0.1	0.2	-0.4	0.1
Whole body fat mass	0.1	0.3	0.4	-0.4	-0.6
Arm predicted mass (right)	0.1	0.6	0.9	-1.0	0.5
Leg pain on walking	0.1	0.2	0.3	0.6	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.3	-0.2
Medication: Aspirin	0.1	0.1	0.1	0.3	0.2
Whole body fat-free mass	0.1	0.7	1.5	-1.2	-0.1
Mood swings	0.1	0.3	0.4	-0.3	0.6
Loneliness, isolation	0.1	0.2	0.2	-0.4	-0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.2	-0.5
Whole body water mass	0.1	0.8	1.5	-1.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	0.3	0.3
Ever smoked	0.1	0.1	0.2	0.1	0.4
Leg fat percentage (left)	0.1	0.3	0.3	0.6	-0.5
Arm fat-free mass (left)	0.1	0.3	0.5	-0.7	0.4
Average weekly beer plus cider intake	0.1	0.2	0.4	0.0	0.6
Alcohol drinker status: Previous	0.1	0.2	0.3	0.5	-0.2
Impedance of whole body	0.1	0.4	0.4	0.6	0.6
Arm predicted mass (left)	0.1	0.3	0.5	-0.7	0.2
Coronary Artery Disease (CAD)	0.0	0.1	0.1	0.2	0.2
Mean Putamen Volume	0.0	0.0	0.0	-0.2	-0.1
HDL Cholesterol	0.0	0.1	0.1	0.4	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.2	0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	0.0	0.3
Tanning	0.0	0.0	0.1	-0.3	-0.0
Medication: Co-codamol	0.0	0.1	0.1	0.1	-0.3
Townsend deprivation index at recruitment	0.0	0.1	0.1	-0.3	-0.1
Current tobacco smoking	0.0	0.0	0.1	-0.3	-0.1
Multivitamins +/- minerals	0.0	0.0	0.0	-0.2	0.0
Sitting height	0.0	0.1	0.1	-0.3	0.2
Hip circumference	0.0	0.1	0.2	0.4	-0.1
Number of live births	0.0	0.0	0.0	0.0	-0.2
Trunk predicted mass	0.0	0.3	0.5	-0.7	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.2	-0.1
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	-0.1	-0.1
Leg fat mass (right)	0.0	0.1	0.1	0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.1	-0.1
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.2	0.0
Medication: Aspirin	0.0	0.0	0.0	0.0	-0.1
Smoking status: Current	0.0	0.0	0.0	0.1	0.1
Mother’s age at death	0.0	0.0	0.0	0.2	0.2
Age started oral contraceptive pill	0.0	0.0	0.0	0.0	-0.2
Leg fat mass (left)	0.0	0.1	0.2	-0.0	-0.5

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