Best TWAS P=6.57e-26 · Best GWAS P=5.94e-31 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RAB24 | 0.14 | 0.06 | enet | 14 | 0.09 | 4.2e-11 | 9.19 | 10.5 | 6.6e-26 | 0.57 | 0.80 | 0.20 | TRUE |
2 | GTEx | Adipose Subcutaneous | RAB24 | 0.17 | 0.08 | enet | 26 | 0.14 | 1.7e-11 | 9.35 | 6.6 | 4.8e-11 | 0.31 | 0.28 | 0.72 | FALSE |
3 | GTEx | Artery Tibial | RAB24 | 0.18 | 0.09 | lasso | 3 | 0.07 | 2.3e-06 | 9.35 | 7.7 | 1.4e-14 | 0.52 | 0.06 | 0.94 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | RAB24 | 0.37 | 0.26 | lasso | 6 | 0.24 | 1.7e-08 | -6.10 | 6.5 | 6.1e-11 | 0.35 | 0.94 | 0.03 | FALSE |
5 | GTEx | Colon Transverse | MXD3 | 0.22 | 0.09 | lasso | 5 | 0.13 | 8.2e-07 | -6.10 | -5.2 | 2.2e-07 | -0.32 | 0.97 | 0.00 | FALSE |
6 | GTEx | Esophagus Mucosa | UIMC1 | 0.08 | 0.00 | lasso | 5 | 0.00 | 3.5e-01 | -8.42 | -9.1 | 9.7e-20 | -0.42 | 0.13 | 0.03 | FALSE |
7 | GTEx | Esophagus Mucosa | FGFR4 | 0.18 | 0.16 | enet | 8 | 0.16 | 9.2e-11 | -8.40 | -7.5 | 6.1e-14 | -0.35 | 1.00 | 0.00 | TRUE |
8 | GTEx | Nerve Tibial | FGFR4 | 0.44 | 0.48 | lasso | 7 | 0.47 | 2.1e-37 | -8.40 | -8.4 | 5.3e-17 | -0.39 | 1.00 | 0.00 | FALSE |
9 | GTEx | Pituitary | FGFR4 | 0.30 | 0.21 | lasso | 3 | 0.11 | 1.0e-03 | -6.42 | -7.2 | 7.3e-13 | -0.47 | 0.11 | 0.17 | TRUE |
10 | GTEx | Skin Not Sun Exposed Suprapubic | FGFR4 | 0.19 | 0.11 | lasso | 5 | 0.11 | 8.3e-07 | -8.40 | -6.9 | 4.2e-12 | -0.39 | 0.91 | 0.00 | FALSE |
11 | GTEx | Stomach | MXD3 | 0.21 | 0.03 | lasso | 7 | 0.08 | 1.4e-04 | -6.06 | -5.9 | 4.6e-09 | -0.26 | 0.56 | 0.02 | FALSE |
12 | GTEx | Uterus | MXD3 | 0.51 | 0.10 | enet | 30 | 0.24 | 1.1e-05 | 0.39 | -5.4 | 8.5e-08 | -0.11 | 0.08 | 0.10 | FALSE |
13 | METSIM | Adipose | RAB24 | 0.05 | 0.02 | lasso | 4 | 0.02 | 1.2e-03 | 9.19 | 9.6 | 1.3e-21 | 0.60 | 0.15 | 0.72 | TRUE |
14 | ROSMAP | Brain Pre-frontal Cortex | FGFR4 | 0.26 | 0.14 | lasso | 20 | 0.21 | 4.5e-26 | -6.42 | -5.1 | 3.1e-07 | -0.42 | 1.00 | 0.00 | FALSE |
15 | ROSMAP | Brain Pre-frontal Cortex | PRELID1 | 0.05 | 0.05 | enet | 10 | 0.05 | 1.8e-07 | -5.93 | 6.2 | 7.6e-10 | 0.31 | 1.00 | 0.00 | FALSE |
16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MXD3 | 0.02 | 0.02 | enet | 4 | 0.02 | 1.8e-04 | -5.97 | -6.0 | 1.9e-09 | -0.32 | 0.83 | 0.00 | FALSE |
17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MXD3 | 0.04 | 0.02 | lasso | 3 | 0.02 | 2.9e-03 | -5.51 | -6.3 | 3.1e-10 | -0.34 | 0.04 | 0.20 | FALSE |
18 | The Cancer Genome Atlas | Lung Adenocarcinoma | MXD3 | 0.04 | 0.02 | blup | 41 | 0.02 | 5.6e-04 | -5.51 | -6.5 | 8.9e-11 | -0.30 | 0.25 | 0.04 | FALSE |
19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FGFR4 | 0.11 | 0.04 | enet | 19 | 0.06 | 8.7e-07 | -6.74 | 6.0 | 1.6e-09 | 0.42 | 0.94 | 0.02 | TRUE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MXD3 | 0.04 | 0.02 | blup | 40 | 0.03 | 2.8e-04 | -3.78 | -5.2 | 1.6e-07 | -0.20 | 0.42 | 0.02 | TRUE |
21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RAB24 | 0.23 | 0.04 | enet | 19 | 0.06 | 6.5e-07 | 9.19 | 6.7 | 1.7e-11 | 0.27 | 0.00 | 0.98 | FALSE |
22 | The Cancer Genome Atlas | Thyroid Carcinoma | MXD3 | 0.05 | 0.04 | lasso | 5 | 0.04 | 1.8e-04 | -5.96 | -6.0 | 1.7e-09 | -0.29 | 0.61 | 0.02 | FALSE |