Best TWAS P=1.78e-18 · Best GWAS P=2.33e-30 conditioned to 4e-04
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LPA | 0.10 | 0.02 | lasso | 5 | 0.04 | 3.2e-06 | -2.15 | 6.1 | 1.0e-09 | -0.63 | 0.04 | 0.92 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SLC22A3 | 0.10 | 0.02 | blup | 582 | 0.05 | 4.4e-07 | 7.69 | 8.2 | 2.3e-16 | -0.63 | 0.61 | 0.38 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | SLC22A3 | 0.13 | 0.06 | enet | 7 | 0.09 | 1.3e-05 | 7.31 | 7.7 | 1.4e-14 | -0.63 | 0.51 | 0.48 | FALSE |
| 4 | GTEx | Brain Caudate basal ganglia | SLC22A3 | 0.15 | 0.10 | enet | 39 | 0.11 | 5.6e-04 | 9.68 | 8.8 | 1.8e-18 | -0.71 | 0.04 | 0.90 | TRUE |
| 5 | GTEx | Brain Frontal Cortex BA9 | SLC22A3 | 0.26 | 0.08 | lasso | 6 | 0.05 | 1.5e-02 | 5.48 | 8.5 | 1.5e-17 | -0.63 | 0.16 | 0.57 | TRUE |
| 6 | GTEx | Colon Transverse | SLC22A3 | 0.18 | 0.00 | enet | 11 | 0.00 | 5.2e-01 | -5.11 | 5.7 | 9.5e-09 | -0.40 | 0.09 | 0.40 | TRUE |
| 7 | GTEx | Esophagus Mucosa | SLC22A3 | 0.19 | 0.08 | enet | 47 | 0.12 | 1.7e-08 | -7.25 | 6.4 | 1.2e-10 | -0.58 | 0.69 | 0.31 | FALSE |
| 8 | GTEx | Nerve Tibial | SLC22A3 | 0.20 | 0.10 | lasso | 7 | 0.13 | 3.2e-09 | 7.36 | 7.4 | 1.3e-13 | -0.56 | 0.99 | 0.00 | FALSE |
| 9 | GTEx | Ovary | SLC22A3 | 0.33 | 0.29 | lasso | 6 | 0.23 | 2.8e-06 | 8.18 | 8.3 | 1.0e-16 | -0.65 | 0.11 | 0.81 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | SLC22A3 | 0.15 | 0.05 | lasso | 9 | 0.05 | 9.9e-04 | 5.89 | 8.3 | 8.5e-17 | -0.65 | 0.24 | 0.69 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | SLC22A3 | 0.29 | 0.14 | lasso | 10 | 0.20 | 3.7e-16 | -4.49 | 7.8 | 5.6e-15 | -0.48 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Testis | SLC22A3 | 0.19 | 0.01 | lasso | 14 | 0.05 | 2.6e-03 | 9.37 | 8.3 | 1.4e-16 | -0.66 | 0.42 | 0.53 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | SLC22A3 | 0.14 | 0.20 | lasso | 10 | 0.19 | 2.4e-24 | 7.69 | 8.0 | 1.5e-15 | -0.67 | 1.00 | 0.00 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | SLC22A1 | 0.04 | 0.00 | bslmm | 534 | 0.01 | 1.3e-02 | 0.18 | -6.1 | 1.3e-09 | 0.45 | 0.06 | 0.09 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | SLC22A3 | 0.17 | 0.06 | lasso | 5 | 0.04 | 2.8e-03 | 5.11 | -5.9 | 3.2e-09 | 0.45 | 0.07 | 0.20 | FALSE |
| 16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LPAL2 | 0.07 | 0.00 | blup | 74 | 0.04 | 1.1e-03 | 3.62 | -7.4 | 1.1e-13 | 0.75 | 0.05 | 0.50 | TRUE |