Best TWAS P=1.13e-43 · Best GWAS P=1.27e-42 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SNX10 | 0.35 | 0.24 | lasso | 10 | 0.24 | 1.7e-19 | 13.68 | -13.8 | 1.8e-43 | -0.98 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC004540.4 | 0.23 | 0.19 | lasso | 4 | 0.18 | 2.8e-14 | 13.68 | -13.9 | 1.1e-43 | -0.99 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | AC004540.4 | 0.15 | 0.00 | enet | 29 | 0.03 | 1.5e-02 | -4.64 | -7.1 | 1.3e-12 | -0.46 | 0.04 | 0.69 | FALSE |
| 4 | GTEx | Brain Cerebellum | CBX3 | 0.28 | 0.01 | lasso | 5 | 0.13 | 9.1e-05 | -0.31 | 7.1 | 1.1e-12 | 0.43 | 0.06 | 0.18 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | SNX10 | 0.17 | 0.02 | lasso | 6 | 0.04 | 4.4e-03 | 10.11 | -9.4 | 4.2e-21 | -0.62 | 0.01 | 0.96 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | SNX10 | 0.28 | 0.04 | lasso | 4 | 0.03 | 5.7e-02 | -6.93 | -9.6 | 1.1e-21 | -0.62 | 0.02 | 0.70 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | HOTAIRM1 | 0.26 | 0.02 | lasso | 4 | 0.04 | 1.8e-02 | -4.66 | -6.2 | 6.9e-10 | 0.06 | 0.12 | 0.38 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | HOTAIRM1 | 0.35 | 0.32 | lasso | 6 | 0.28 | 9.2e-11 | -4.66 | -5.1 | 2.9e-07 | 0.07 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Esophagus Muscularis | HOTAIRM1 | 0.25 | 0.24 | enet | 6 | 0.25 | 3.6e-15 | -4.00 | -5.2 | 2.5e-07 | 0.07 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Lung | HOTAIRM1 | 0.25 | 0.18 | lasso | 7 | 0.14 | 4.3e-11 | -4.66 | -5.4 | 5.4e-08 | 0.06 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Nerve Tibial | CTB-119C2.1 | 0.17 | 0.01 | enet | 3 | 0.01 | 1.3e-01 | -5.32 | 5.3 | 1.1e-07 | 0.27 | 0.09 | 0.05 | FALSE |
| 12 | GTEx | Stomach | HOTAIRM1 | 0.14 | 0.12 | lasso | 5 | 0.15 | 8.8e-08 | -7.52 | -8.0 | 1.3e-15 | 0.02 | 0.30 | 0.49 | FALSE |
| 13 | GTEx | Testis | AC004540.4 | 0.23 | 0.04 | enet | 6 | 0.03 | 1.1e-02 | 13.68 | -12.9 | 6.9e-38 | -0.87 | 0.00 | 0.97 | FALSE |
| 14 | GTEx | Thyroid | CTB-119C2.1 | 0.11 | 0.00 | lasso | 2 | 0.00 | 3.7e-01 | -5.32 | 5.1 | 3.1e-07 | 0.25 | 0.07 | 0.04 | FALSE |
| 15 | METSIM | Adipose | SNX10 | 0.22 | 0.22 | lasso | 7 | 0.22 | 2.0e-32 | 13.68 | -13.7 | 9.6e-43 | -1.00 | 0.00 | 1.00 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | AC004540.5 | 0.18 | 0.13 | lasso | 7 | 0.15 | 2.7e-18 | 4.10 | -5.3 | 1.1e-07 | -0.18 | 1.00 | 0.00 | TRUE |
| 17 | YFS | Blood | HOXA9 | 0.06 | 0.05 | lasso | 6 | 0.06 | 2.0e-19 | -6.70 | 8.5 | 1.6e-17 | -0.03 | 1.00 | 0.00 | TRUE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNX10 | 0.05 | 0.05 | enet | 9 | 0.06 | 1.8e-11 | 10.11 | -10.1 | 5.3e-24 | -0.60 | 0.99 | 0.01 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SNX10 | 0.03 | 0.02 | blup | 64 | 0.02 | 1.2e-03 | 1.26 | -5.7 | 1.2e-08 | -0.23 | 0.04 | 0.04 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | JAZF1 | 0.12 | 0.09 | lasso | 4 | 0.09 | 2.1e-09 | 9.34 | 9.8 | 1.3e-22 | 0.02 | 0.04 | 0.96 | TRUE |