Best TWAS P=7.8e-19 · Best GWAS P=3.61e-33 conditioned to 2.78e-26
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | ABCA1 | 0.20 | 0.04 | lasso | 3 | 0.03 | 1.6e-03 | -8.7 | -8.9 | 7.8e-19 | -0.01 | 0.16 | 0.09 | TRUE |
| 2 | YFS | Blood | ABCA1 | 0.06 | 0.01 | lasso | 8 | 0.02 | 1.3e-08 | -5.1 | 6.5 | 1.0e-10 | -0.10 | 0.75 | 0.20 | TRUE |
| 3 | YFS | Blood | NIPSNAP3B | 0.02 | 0.00 | blup | 590 | 0.01 | 4.6e-04 | -4.3 | 5.2 | 2.4e-07 | -0.21 | 0.09 | 0.02 | TRUE |