Best TWAS P=6.05e-10 · Best GWAS P=3.56e-10 conditioned to 0.000399
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | TMEM245 | 0.37 | 0.07 | lasso | 7 | 0.19 | 4.7e-15 | -5.1 | -5.7 | 9.7e-09 | 0.51 | 0.55 | 0.45 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | FAM206A | 0.22 | 0.06 | lasso | 13 | 0.10 | 9.2e-08 | -5.0 | 5.4 | 6.3e-08 | -0.62 | 0.70 | 0.30 | FALSE |
3 | METSIM | Adipose | CTNNAL1 | 0.16 | 0.08 | enet | 31 | 0.12 | 1.2e-17 | 3.8 | -5.3 | 8.9e-08 | 0.43 | 1.00 | 0.00 | FALSE |
4 | NTR | Blood | C9orf5 | 0.05 | 0.02 | enet | 14 | 0.03 | 2.2e-10 | 2.6 | -5.6 | 2.0e-08 | 0.51 | 0.57 | 0.43 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C9orf5 | 0.04 | 0.02 | enet | 4 | 0.05 | 5.5e-06 | -5.1 | -6.1 | 9.6e-10 | 0.65 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C9orf4 | 0.06 | 0.03 | blup | 80 | 0.04 | 7.0e-04 | -5.1 | -5.7 | 9.1e-09 | 0.67 | 0.09 | 0.43 | FALSE |
7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C9orf5 | 0.16 | 0.01 | blup | 88 | 0.09 | 1.5e-04 | 2.2 | -5.3 | 1.4e-07 | 0.41 | 0.02 | 0.66 | FALSE |
8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C9orf5 | 0.15 | 0.02 | blup | 88 | 0.09 | 2.1e-09 | 3.4 | -5.8 | 7.0e-09 | 0.42 | 0.01 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C9orf5 | 0.15 | 0.02 | blup | 89 | 0.02 | 1.2e-01 | 3.2 | -5.5 | 4.7e-08 | 0.49 | 0.02 | 0.34 | FALSE |
10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C9orf5 | 0.06 | 0.06 | blup | 88 | 0.03 | 3.0e-03 | -5.1 | -5.8 | 7.3e-09 | 0.52 | 0.01 | 0.95 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf5 | 0.08 | 0.04 | blup | 88 | 0.07 | 1.1e-07 | -5.1 | -6.2 | 6.0e-10 | 0.53 | 0.01 | 0.99 | TRUE |