Hub : Genes

ABCA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.341	0.0996	1.0e-03	0.038	NA	0.081	NA	0.079	1.7e-02	NA	7.4e-04	NA	8.7e-04
2	GTEx	Cells Transformed fibroblasts	0.197	0.0710	4.4e-03	0.043	NA	0.003	NA	0.033	3.3e-04	NA	1.9e-01	NA	1.6e-03
3	YFS	Blood	0.060	0.0172	2.0e-06	0.014	0.019	0.023	0.021	0.025	1.2e-05	5.8e-07	4.0e-08	1.7e-07	1.3e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.8	1.2	1.1	0.7	-0.9
Bipolar Disorder or Schizophrenia	0.7	1.7	3.0	1.3	1.7	-0.6
Depressed Affect (Nagel 2018)	0.4	0.7	1.4	-0.9	0.3	1.2
Depression (Nagel 2018)	0.1	0.2	0.2	-0.2	-0.4	0.5
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	-0.1	-0.8	-0.4
Neuroticism (Nagel 2018)	0.3	0.6	1.0	-0.6	-0.7	1.0
Schizophrenia (2018)	0.6	1.2	2.9	0.8	1.7	-0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	1.0	0.5	0.2
Worry (Nagel 2018)	0.2	0.5	1.0	-0.6	-0.3	1.0
Alzheimer’s Disease (in mother)	1.6	1.8	4.1	1.1	2.0	-0.4
Alzheimer’s Disease (in father)	0.3	0.3	1.0	0.0	-1.0	-0.0
Alzheimer’s Disease (including proxy)	1.1	1.7	3.5	1.0	1.9	-0.7
Crohns Disease (2017)	0.6	1.2	3.2	-0.4	-0.6	-1.8
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	-0.3	-0.2	0.0
Ulcerative Colitis (UC)	0.8	1.4	3.9	-0.5	0.2	2.0
Major Depression (MDD)	1.9	2.3	4.8	-2.2	0.4	1.4
Reaction Time	3.1	5.9	9.8	-3.1	-2.3	1.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.0	-0.5	-1.4	0.2
Breast Cancer	0.4	0.9	1.9	1.4	0.7	-0.4
Ovarian Cancer	0.3	0.5	0.7	0.9	-0.0	-0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.0	1.4	2.9	-0.9	0.8	-1.7
Bipolar Disorder (2011)	0.7	0.7	1.8	-0.4	0.5	1.3
Body Mass Index (BMI) (2010)	0.7	1.0	2.3	0.6	1.5	-0.5
Coronary Artery Disease (CAD)	1.6	1.9	4.8	0.8	-2.2	0.4
Crohns Disease (2012)	0.6	0.9	2.6	0.2	0.1	-1.6
Mean Putamen Volume	0.4	0.5	0.6	0.8	-0.7	0.5
Fasting Glucose	0.2	0.2	0.7	-0.1	0.8	0.1
HbA1C	0.7	0.7	1.3	0.8	-0.6	1.2
HDL Cholesterol	15.2	25.3	73.9	1.3	-8.6	0.5
LDL Cholesterol	7.5	11.9	25.4	-2.6	-5.0	1.9
Lupus	0.3	0.5	1.3	-0.1	0.3	-1.1
Neuroticism (2016)	0.7	1.0	1.4	-1.2	0.3	1.2
Primary Biliary Cirrhosis	0.5	0.7	1.6	-0.8	-0.1	-1.3
Rheumatoid Arthritis	0.5	0.7	1.3	-0.8	-1.1	0.5
Schizophrenia (2014)	1.4	3.1	5.8	2.4	1.9	-0.3
Triglycerides	2.5	4.0	9.5	-0.8	-3.1	1.4
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.5	1.2	0.3	-0.1
Ulcerative Colitis	0.6	0.9	2.5	0.3	-0.4	1.6
Blood Eosinophil Count	0.2	1.2	3.1	0.4	1.8	0.6
Blood Platelet Count	0.2	2.2	3.3	0.4	-1.8	-1.8
Blood Red Count	0.9	8.4	17.1	-4.1	-0.7	2.8
Blood White Count	0.1	1.0	1.5	-1.1	1.2	-0.5
Heel T-Score	0.0	0.3	0.8	-0.0	-0.9	0.2
BMI	0.7	4.3	5.6	1.6	2.4	-2.2
Height	0.2	4.3	6.8	-2.6	1.3	2.1
Waist Hip Ratio (WHR)	9.4	42.3	78.6	-2.5	-8.9	6.5
Systolic Blood Pressure	0.6	3.0	5.1	0.4	-2.0	2.2
Smoking Status	0.2	0.6	1.0	-0.5	1.0	0.7
Allergy or Eczema	0.5	1.3	2.1	-0.4	1.5	-1.3
Cardiovascular Disease	0.6	2.1	4.9	-0.2	-2.2	1.2
Hypothyroidism (self reported)	0.4	0.8	1.6	0.8	1.3	-0.5
Respiratory disease	0.2	0.4	0.7	0.5	0.5	0.8
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.0	0.1	-1.6	-1.7
Lung FEV1/FVC ratio	0.9	4.4	8.3	-2.9	-2.2	0.2
Lung FVC	0.7	3.5	10.0	-0.4	3.2	0.5
Neuroticism	0.4	0.9	1.8	-0.6	0.7	1.3
Chronotype (morning person)	0.4	0.9	2.6	0.1	1.6	-0.4
Hair Pigment	0.1	3.7	7.8	1.0	-2.8	-1.5
Tanning	0.0	0.0	0.1	0.3	0.2	-0.0
Hand grip strength (left)	0.7	1.7	3.5	0.9	-1.9	1.0
Number of treatments/medications taken	0.6	1.1	3.0	0.2	0.4	1.7
Average weekly spirits intake	0.3	0.4	1.0	-0.4	-0.0	1.0
Sensitivity / hurt feelings	0.3	0.5	0.7	-0.8	0.5	0.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	-1.3	0.3	0.6
Hearing difficulty/problems: Yes	1.1	1.6	2.6	-1.6	1.5	-0.2
Relative age of first facial hair	1.5	3.1	7.4	1.1	-2.7	-0.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.0	-0.2	-0.7	1.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	-1.2	1.1	-0.4
Ever had hysterectomy (womb removed)	1.7	1.9	5.4	-0.4	0.4	2.3
Systolic blood pressure, automated reading	0.2	0.7	1.0	-1.0	-0.9	0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.0	-0.3	-0.4
Angina	2.5	3.2	5.3	-2.3	-0.7	2.0
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.5	0.4	-0.9
Vitamin and mineral supplements	0.9	1.2	2.2	-0.2	-1.5	-1.2
Supplements: Zinc	1.9	2.1	5.6	0.1	2.4	0.8
Medication: Co-codamol	1.6	1.8	5.0	0.1	0.7	2.2
Medication: Metformin	1.9	2.6	5.4	-1.0	-1.3	-2.3
Diabetes (father)	0.3	0.4	0.7	-0.4	-0.9	0.5
Diabetes (mother)	3.5	4.5	9.2	0.3	-3.0	-2.0
Severe depression (siblings)	0.7	0.8	1.7	-1.3	0.7	-0.5
Pack years adult smoking proportion	0.5	0.8	1.3	-1.2	-0.7	-0.7
Impedance of leg (right)	0.1	0.7	1.1	1.0	-0.2	1.0
Leg fat-free mass (left)	0.2	0.9	2.7	0.2	1.6	-0.3
Trunk fat percentage	1.4	5.5	8.9	2.5	3.0	-1.2
Hand grip strength (right)	0.9	2.4	4.6	-0.7	-1.4	2.2
Townsend deprivation index at recruitment	0.6	0.9	2.4	-1.6	0.3	-0.4
Current tobacco smoking	0.5	0.8	1.5	1.0	1.2	0.2
Average weekly fortified wine intake	0.3	0.3	0.4	-0.7	-0.6	0.2
Maternal smoking around birth	0.6	0.8	1.5	-1.0	1.2	-0.1
Fed-up feelings	0.9	1.6	4.3	0.4	2.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.5	-1.2	0.1	0.7
Relative age voice broke	0.5	0.7	1.0	1.0	-0.7	-0.9
Taking other prescription medications	0.5	0.8	1.9	-0.6	0.3	1.4
Age when periods started (menarche)	0.5	1.1	1.9	1.2	-0.1	1.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.2	-0.0	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	4.2	-1.4	-1.7	2.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	-0.4	-1.1	0.3
Qualifications: CSEs or equivalent	1.6	2.1	4.6	-0.7	-1.1	2.1
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-1.1	-0.0	0.8
High blood pressure	0.3	0.7	1.9	-0.3	0.4	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.2	-0.2	1.5	-0.7
Multivitamins +/- minerals	0.1	0.2	0.3	0.3	0.5	0.4
Stomach or abdominal pain in last month	0.9	1.1	3.1	-0.3	0.4	1.8
Supplements: Glucosamine	0.4	0.5	1.1	0.4	1.1	0.3
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	3.9	0.2	-2.0	0.7
Medication: Atenolol	0.6	0.8	1.5	0.7	-0.6	1.2
Medication: Levothyroxine sodium	0.4	0.6	1.6	0.3	1.3	-0.3
Sitting height	0.2	1.2	2.0	-1.2	1.4	0.2
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.5	0.6	0.3
High blood pressure (mother)	1.5	2.1	3.4	-1.8	-1.5	0.9
Body mass index (BMI)	0.4	1.9	2.8	1.4	1.7	-1.0
Impedance of leg (left)	0.2	0.7	1.6	1.2	-0.5	0.6
Leg predicted mass (left)	0.2	0.9	2.6	0.2	1.6	-0.4
Trunk fat mass	0.8	3.5	6.8	1.9	2.6	-0.6
Waist circumference	0.2	0.8	2.0	0.5	-0.4	1.4
Number of incorrect matches in round	0.8	1.4	3.0	0.8	1.7	-0.7
Past tobacco smoking	0.3	0.5	1.1	0.5	-0.5	-1.0
Alcohol usually taken with meals	0.4	0.6	0.9	1.0	1.0	-0.2
Nervous feelings	0.9	1.6	3.1	-1.8	-1.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	5.0	-2.2	0.1	2.2
Hearing difficulty/problems with background noise	0.6	1.0	2.7	-1.6	0.1	-0.5
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	0.3	-0.1	-1.0
Had menopause	0.7	0.9	2.0	-0.8	1.4	0.1
Had other major operations	1.1	1.4	3.0	1.7	0.6	-0.8
Forced vital capacity (FVC)	0.2	0.8	1.0	-0.8	1.0	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.4	-0.6	-1.2	0.0
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.8	-0.8	0.5	2.0
Qualifications: None of the above	0.1	0.3	0.8	-0.1	-0.0	0.9
Financial difficulties in last 2 years	0.5	0.7	1.1	-1.1	0.7	0.6
Mouth/teeth dental problems	0.2	0.3	1.0	0.1	0.2	-1.0
Heart attack	1.3	1.7	2.7	0.4	-1.6	1.5
Allergy	0.4	0.8	1.7	-0.8	-1.3	0.2
Pain all over the body in last month	0.7	0.7	1.4	-1.2	0.8	0.4
Diabetes (self-reported)	1.5	2.2	4.1	0.3	-1.6	-2.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.1	0.2	-0.5
Medication: Ramipril	0.7	0.9	2.3	-0.6	-1.5	-0.5
Medication: Simvastatin	1.8	2.6	5.5	-1.4	-2.3	-0.5
Fluid intelligence score	0.7	1.4	3.0	-0.2	-1.7	1.1
Illnesses of siblings	0.1	0.1	0.2	0.4	0.2	0.4
Neuroticism score	0.9	1.8	2.5	-1.1	1.3	1.6
Weight	0.3	1.7	4.1	0.8	2.0	-0.5
Impedance of arm (right)	0.5	2.3	5.0	2.2	1.3	-0.2
Arm fat percentage (right)	1.0	4.1	6.3	2.1	2.5	-1.1
Trunk fat-free mass	0.1	0.6	1.5	-1.2	0.5	0.2
Hip circumference	2.0	8.4	18.2	2.2	4.3	-1.5
Time employed in main current job	0.8	0.9	1.6	-1.3	0.8	0.7
Alcohol intake versus 10 years previously	2.1	3.2	4.2	-1.9	-2.1	1.3
Father’s age at death	3.4	4.5	8.3	2.9	2.3	-0.3
Worrier / anxious feelings	0.3	0.6	1.2	-1.1	0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.3	-0.8	0.8	1.5
Falls in the last year	0.6	0.9	2.2	0.1	0.6	-1.5
Hair/balding pattern: Pattern 3	3.0	4.5	9.1	-3.0	-1.2	1.7
Number of live births	0.9	1.3	2.9	1.7	1.0	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.3	-1.5	0.5	0.9
Pulse rate	0.4	0.7	2.0	1.4	-0.2	0.0
Happiness	0.0	0.0	0.0	-0.2	0.2	-0.0
Noisy workplace	0.3	0.4	1.0	0.2	0.2	1.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.6	0.6	0.5	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.5	-0.7	-0.3	0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	1.1	-0.9	-0.1	1.1
Asthma	0.8	1.7	2.4	1.6	0.8	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.2	1.4	1.5	0.0
Medication: Cholesterol lowering	2.1	3.3	5.5	-2.0	-2.3	0.5
Depression (self-reported)	0.2	0.2	0.6	0.2	-0.3	-0.8
Medication: Lansoprazole	0.6	0.7	1.2	-1.1	0.2	1.0
Prospective memory result	0.5	0.6	1.6	1.3	0.0	0.4
Lung cancer (father)	0.0	0.1	0.1	-0.2	0.3	-0.1
Illnesses of mother	0.6	0.7	1.3	0.1	0.9	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.9	-1.1	0.2	1.4
Pulse wave Arterial Stiffness index	2.9	3.4	7.7	-1.3	0.8	2.8
Impedance of arm (left)	0.5	2.4	5.6	2.4	1.2	0.1
Arm fat mass (right)	0.7	3.1	4.7	1.7	2.2	-1.2
Trunk predicted mass	0.1	0.6	1.4	-1.2	0.5	0.1
Standing height	0.1	1.0	1.2	-1.1	1.1	0.9
Length of working week for main job	1.1	1.2	1.9	0.1	1.4	-1.3
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.1	0.6	0.2
Breastfed as a baby	2.2	2.7	5.5	-2.3	0.8	-1.5
Tense / ‘highly strung’	0.1	0.2	0.5	0.0	0.7	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.1	-0.9	-0.2	1.0
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	1.2	0.8	-0.5
Birth weight of first child	0.5	1.0	1.7	-1.3	0.7	0.8
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.3	-0.4	0.6
Pulse wave reflection index	4.1	5.1	6.3	-1.8	2.3	2.5
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.0	-1.4	-1.1	0.6
Loud music exposure frequency	0.9	1.0	2.8	-1.7	0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.8	-0.2	-1.3	0.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	3.3	1.8	-0.1	-0.1
Blood clot in the leg (DVT)	2.3	3.0	5.7	2.4	0.1	-1.8
Medication: Paracetamol	1.0	1.6	3.9	-0.2	2.0	1.0
Headache pain in last month	0.7	1.2	2.2	-1.1	0.3	1.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.3	1.5	-0.1	-1.4
Glaucoma (self-reported)	4.6	5.4	8.9	0.6	3.0	2.7
Gout (self-reported)	0.7	1.0	1.4	-1.2	-0.6	1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.7	1.3	1.3	0.0
Medication: Amlodipine	0.7	1.0	2.5	0.4	-1.6	0.5
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.9	-0.5	1.0	1.7
Birth weight	0.3	0.7	1.3	-0.4	-0.7	1.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.4	-1.2	0.6	-0.6
High blood pressure (siblings)	0.1	0.1	0.1	0.2	-0.4	0.3
Forced vital capacity (FVC), Best measure	0.3	1.0	1.8	-0.4	1.0	1.3
Body fat percentage	1.0	4.1	6.2	2.4	2.5	-0.6
Leg fat percentage (right)	0.7	2.4	4.3	2.1	1.7	-0.3
Arm fat-free mass (right)	0.1	0.4	0.6	-0.7	0.8	0.1
Exposure to tobacco smoke outside home	0.4	0.6	1.0	-0.6	0.6	-1.0
Comparative body size at age 10	0.5	1.3	1.5	1.1	-1.1	1.2
Number of full brothers	0.2	0.2	0.4	0.6	-0.3	0.4
Worry too long after embarrassment	0.2	0.3	0.5	0.7	0.6	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	0.1	-0.1	-1.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.0	0.0	1.4	0.9
Number of children fathered	0.4	0.4	0.7	0.2	-0.7	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	5.3	-0.4	2.3	-0.0
Age at first live birth	0.1	0.2	0.6	0.7	-0.3	0.1
Pulse wave peak to peak time	2.7	3.2	7.5	1.1	-0.9	-2.7
Health satisfaction	0.3	0.4	1.2	0.1	-1.1	0.3
Shortness of breath walking on level ground	0.6	0.7	1.1	0.9	-0.4	1.0
Qualifications: College or University degree	0.5	1.5	4.3	0.2	0.0	-2.1
Eye problems/disorders: None of the above	1.2	1.4	3.3	-0.3	-1.8	-1.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	1.4	-1.2	-1.2	1.2
Emphysema/chronic bronchitis	0.9	1.0	2.8	-0.3	0.2	1.7
Medication for pain relief, constipation, heartburn	0.8	1.3	3.6	0.1	-0.5	-1.9
Neck or shoulder pain in last month	1.4	2.0	4.4	2.1	1.2	0.4
Medication: Blood pressure	1.0	1.8	5.0	-0.3	0.6	2.2
Angina (self-reported)	2.1	2.8	4.6	-2.1	-0.8	1.8
Migraine (self-reported)	0.3	0.4	0.5	-0.4	-0.7	0.7
Medication: Ibuprofen	1.0	1.1	2.5	0.9	1.6	-0.3
Medication: Allopurinol	1.2	1.6	2.8	-1.4	-0.0	1.7
Medication: Omeprazole	0.6	0.8	1.0	-0.5	-1.0	1.0
Medication: Seretide 50 evohaler	1.1	1.2	1.5	-1.1	1.2	1.0
Mean time to correctly identify matches	1.8	3.5	7.9	-2.8	-1.4	0.8
Heart disease (mother)	0.5	0.6	1.2	0.8	-1.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.5	1.6	0.7	-0.0
Whole body fat mass	0.7	3.0	5.2	1.9	2.3	-0.5
Leg fat mass (right)	0.6	2.2	3.5	1.7	1.9	-0.3
Arm predicted mass (right)	0.0	0.2	0.6	-0.8	0.3	0.2
Pulse rate, automated reading	0.8	2.6	4.5	2.1	-1.6	0.8
Alcohol intake frequency.	0.6	1.3	3.3	-1.8	-0.5	0.5
Comparative height size at age 10	0.3	1.5	3.7	-1.9	0.1	0.9
Number of full sisters	0.2	0.2	0.6	-0.8	-0.0	0.3
Suffer from ‘nerves’	0.1	0.1	0.3	0.1	-0.0	0.6
Overall health rating	0.3	0.6	1.4	-0.2	-0.7	1.2
Chest pain or discomfort	0.1	0.2	0.3	-0.4	-0.6	-0.2
Had major operations	1.8	2.1	4.2	-1.4	-0.0	2.0
Age at last live birth	0.8	1.1	1.5	-0.8	-1.1	1.2
Family relationship satisfaction	0.4	0.5	1.2	-1.1	0.0	0.6
Leg pain on walking	0.4	0.5	0.7	0.8	0.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.0	-0.1	-0.1	1.0
Commuting to job workplace: Car/motor vehicle	1.5	1.8	2.6	0.6	-1.6	1.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	0.8	0.5	-0.3
Medication: Aspirin	0.3	0.4	1.2	0.1	-1.1	0.3
Supplements: Vitamin C	0.6	0.8	1.3	0.3	1.1	0.9
Knee pain experienced in last month	1.4	2.1	3.5	1.9	1.6	0.5
Hypertension (Self-reported)	0.1	0.4	0.9	-0.4	0.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	-1.2	0.4	0.8
Illnesses of father: Heart disease	1.7	2.3	5.2	-0.7	-2.3	-1.1
Illnesses of siblings: Diabetes	0.4	0.5	1.3	1.1	-0.4	0.3
Smoking status: Previous	0.8	1.2	2.2	-1.5	-0.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.0	-0.7	-0.4	2.0
Whole body fat-free mass	0.1	0.4	0.8	-0.7	0.9	-0.1
Leg fat-free mass (right)	0.1	0.7	1.6	0.1	1.3	-0.7
Arm fat percentage (left)	1.0	4.2	6.2	2.5	2.3	-1.0
Average weekly red wine intake	0.3	0.5	0.7	0.8	0.7	0.6
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	0.5	0.4	0.7
Mood swings	0.5	1.0	1.8	-1.1	0.1	1.3
Loneliness, isolation	1.9	2.6	3.7	-1.9	1.2	1.6
Long-standing illness, disability or infirmity	1.4	2.2	3.4	-1.8	-1.5	1.0
Ever had bowel cancer screening	0.7	0.8	2.0	0.7	1.4	0.3
Diabetes diagnosed by doctor	1.1	1.8	2.7	-0.5	-1.6	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.1	-0.7	-0.6
Friendships satisfaction	2.8	3.5	7.7	-2.8	-1.6	0.5
Qualifications: nursing, teaching	0.9	1.5	3.2	1.0	-0.4	-1.8
Commuting to job workplace: Walk	1.5	1.6	1.8	-1.2	1.3	1.4
Eye problems/disorders: Cataract	1.3	1.5	3.0	-1.0	1.7	-0.7
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	6.5	-0.3	2.0	2.5
Medication for cholesterol	1.3	2.0	5.8	-0.4	2.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.4	4.0	8.2	-1.6	-1.1	2.9
Back pain experienced in last month	1.9	2.7	5.9	0.8	2.4	1.2
Mineral and other dietary supplements	1.4	1.9	5.2	0.6	-2.3	-0.4
Breast cancer (self-reported)	0.1	0.1	0.2	0.1	0.4	-0.3
Asthma (self-reported)	0.8	1.5	2.0	1.4	0.9	1.4
Osteoporosis (self-reported)	0.9	1.2	3.5	0.1	0.2	1.9
Osteoarthritis (self-reported)	0.7	0.9	2.7	0.3	0.2	1.6
Medication: Aspirin	0.4	0.6	1.2	-0.4	-1.1	0.5
Medication: Gliclazide	2.9	3.3	5.1	-1.2	-2.3	-1.8
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	-0.7	0.3	1.2
Smoking status: Current	0.6	1.0	2.0	0.9	1.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	0.5	0.9	0.0
Whole body water mass	0.1	0.4	0.8	-0.7	0.9	-0.2
Leg predicted mass (right)	0.1	0.7	1.6	0.0	1.3	-0.7
Arm fat mass (left)	0.7	2.8	5.0	1.6	2.2	-0.9
Number of self-reported non-cancer illnesses	0.4	0.8	2.0	0.1	-1.4	0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.4	0.4	0.5	0.6
Miserableness	0.8	1.5	2.3	-1.5	1.1	0.9
Guilty feelings	0.4	0.6	1.4	-1.2	0.4	0.6
Wears glasses or contact lenses	0.5	0.6	0.9	0.4	0.8	0.9
Ever taken oral contraceptive pill	0.4	0.4	1.1	-0.3	-1.1	-0.1
Hearing aid user	1.5	1.7	4.8	-0.5	-0.3	2.2
Mother’s age at death	0.8	1.0	2.1	-0.2	0.9	-1.4
Financial situation satisfaction	0.4	0.4	0.9	-0.9	0.3	0.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	-0.5	0.7	-0.8
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.1	0.3	0.0
Eye problems/disorders: Glaucoma	4.6	5.4	8.4	1.1	2.9	2.6
Medication: Blood pressure	0.3	0.5	1.6	0.1	-1.3	0.0
Pain type(s) experienced in last month: Hip pain	1.8	2.2	6.6	-0.4	2.6	0.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.2	-0.7	1.1	-0.9
High cholesterol (Self-reported)	8.2	14.5	39.1	-2.1	-6.3	0.2
Medication: Bendroflumethiazide	0.5	0.8	2.4	-0.0	0.0	1.5
Medication: Paracetamol	0.7	1.0	2.5	-0.2	1.6	0.7
Medication: Lisinopril	0.2	0.2	0.3	0.6	-0.5	-0.3
Medication: Atorvastatin	4.5	5.6	16.1	-0.2	-4.0	0.8
Illnesses of father: High blood pressure	0.2	0.3	0.7	0.8	0.3	-0.4
Alcohol drinker status: Never	1.7	2.1	4.8	-0.9	0.8	-2.2
Ever smoked	0.2	0.4	0.8	-0.3	0.9	0.6
Basal metabolic rate	0.1	0.5	1.5	-0.2	1.2	-0.2
Leg fat percentage (left)	0.7	2.5	5.1	2.3	1.4	-0.5
Arm fat-free mass (left)	0.1	0.4	0.8	-0.9	0.6	-0.3
Number of operations (self-reported)	0.7	1.0	1.9	1.4	0.5	0.9
Average weekly beer plus cider intake	1.0	1.5	2.9	-1.1	0.6	1.7
Irritability	0.1	0.2	0.3	-0.4	0.5	0.3
Risk taking	0.2	0.3	0.7	0.2	0.6	0.8
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.2	-0.2	-0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.4	-0.6	0.5	-0.5
Age started oral contraceptive pill	0.1	0.1	0.2	0.5	-0.2	-0.4
Diastolic blood pressure, automated reading	0.4	1.2	1.8	0.3	-1.3	1.3
Ever depressed for a whole week	0.5	0.6	1.5	1.2	0.3	0.6
Unable to work because of sickness or disability	0.8	1.0	1.6	-0.8	0.9	-1.2
Commuting to job workplace: Cycle	1.0	1.2	3.4	0.1	0.5	-1.8
Myopia	2.1	3.1	5.1	2.0	-0.2	2.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.1	0.4	0.1	-1.8
Cholesterol lowering medication	6.3	9.3	26.4	-1.2	-5.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	0.1	-0.6	1.1
Pain experienced in last month	0.8	1.4	2.2	-1.0	-1.5	-1.0
Supplements: Calcium	3.2	3.6	5.7	0.6	2.4	2.1
Basal cell carcinoma (self-reported)	1.8	2.1	3.9	1.5	-0.3	-2.0
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.8	0.5	-1.7	1.4
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.8	2.0	0.1	-1.3
Heart disease (siblings)	0.4	0.5	0.9	0.2	0.8	-0.9
Alcohol drinker status: Previous	2.0	2.2	4.1	-2.0	-0.5	1.5
Pack years of smoking	0.6	0.9	2.0	-1.4	-0.6	-0.7
Impedance of whole body	0.3	1.4	3.9	2.0	0.3	0.4
Leg fat mass (left)	0.5	1.9	2.8	1.7	1.6	-0.3
Arm predicted mass (left)	0.1	0.3	0.5	-0.6	0.7	-0.4