Hub : Genes

NIPSNAP3B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0701	0.0255	9.8e-04	0.003	NA	0.028	NA	0.010	1.5e-01	NA	7.9e-04	NA	3.3e-02
2	YFS	Blood	0.0245	0.0098	1.7e-03	-0.001	0.009	0.003	0.009	0.000	5.9e-01	4.6e-04	3.6e-02	0.00046	5.2e-01
3	TCGA	Breast Invasive Carcinoma	0.0525	0.0212	1.2e-04	0.009	0.017	0.018	NA	0.016	4.1e-03	1.3e-04	9.5e-05	NA	2.8e-04
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0637	0.0266	2.5e-03	0.004	0.022	0.004	NA	0.001	9.6e-02	1.6e-03	9.3e-02	NA	2.6e-01
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0738	0.0278	3.6e-04	0.003	0.026	0.014	NA	0.009	1.4e-01	5.9e-04	9.8e-03	NA	2.9e-02
6	TCGA	Brain Lower Grade Glioma	0.0770	0.0271	2.0e-06	0.051	0.048	0.043	NA	0.058	1.7e-06	3.8e-06	1.0e-05	NA	3.6e-07
7	TCGA	Lung Adenocarcinoma	0.0551	0.0248	1.2e-03	0.007	0.013	-0.002	NA	0.005	4.7e-02	1.0e-02	7.4e-01	NA	8.0e-02
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.1680	0.0610	4.7e-04	-0.004	0.010	0.014	NA	-0.004	9.3e-01	6.5e-02	3.6e-02	NA	1.0e+00
9	TCGA	Pancreatic Adenocarcinoma	0.3820	0.1000	7.4e-05	0.055	0.123	0.079	NA	0.074	2.5e-03	8.1e-06	3.4e-04	NA	4.9e-04
10	TCGA	Pheochromocytoma and Paraganglioma	0.2480	0.0860	5.6e-03	-0.007	0.056	0.048	NA	-0.005	9.9e-01	3.0e-03	5.4e-03	NA	5.7e-01
11	TCGA	Prostate Adenocarcinoma	0.0482	0.0225	2.1e-03	0.024	0.017	0.011	NA	0.013	1.3e-03	5.6e-03	2.2e-02	NA	1.4e-02
12	TCGA	Thyroid Carcinoma	0.0870	0.0360	2.1e-03	-0.003	0.012	0.002	NA	0.000	7.6e-01	2.3e-02	2.1e-01	NA	3.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.9	1.5	6.0	0.4	1.6	1.2	-0.3	-0.5	-1.1	0.1	-1.6	1.6	2.5	1.0	0.4
Bipolar Disorder or Schizophrenia	0.3	0.7	3.0	0.3	1.2	0.6	0.5	0.5	-0.2	0.2	-0.2	1.2	1.7	0.9	0.5
Depressed Affect (Nagel 2018)	0.7	1.5	7.3	-1.1	-1.1	-2.7	0.2	-0.2	-0.1	-1.1	1.2	-1.6	-1.2	-0.2	-1.4
Depression (Nagel 2018)	0.4	0.6	2.1	-0.1	-0.3	-1.5	-0.8	-0.4	-1.1	-0.4	0.4	-0.8	-0.2	-0.9	-1.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.5	-0.4	0.8	-1.9	-0.9	-0.3	-1.2	-1.5	0.9	0.9	-0.1	0.3	-0.8
Neuroticism (Nagel 2018)	0.2	0.5	2.6	-0.2	-0.1	-1.6	0.9	0.3	-0.3	-1.0	0.7	-0.6	-0.0	0.7	-0.3
Schizophrenia (2018)	0.2	0.3	1.1	-0.0	0.2	0.1	1.1	1.0	0.6	0.5	0.9	0.3	0.4	0.3	0.5
Schizophrenia vs Biploar Disorder	1.2	1.6	3.4	-1.8	-1.6	1.1	1.7	1.3	1.7	1.8	-0.3	0.1	-0.7	-0.3	0.8
Worry (Nagel 2018)	0.1	0.1	0.7	-0.5	-0.8	-0.0	0.3	0.5	-0.1	0.1	0.1	-0.7	0.1	0.1	0.1
Alzheimer’s Disease (in mother)	1.1	1.3	4.3	-0.5	-2.1	-1.4	-0.4	-1.1	0.8	0.1	0.3	-1.7	-1.5	-1.0	-1.0
Alzheimer’s Disease (in father)	0.3	0.3	2.1	0.4	0.4	-0.5	0.5	-0.2	0.3	0.4	-1.5	0.1	-0.8	-0.1	0.2
Alzheimer’s Disease (including proxy)	0.5	0.8	2.9	0.5	-1.7	-1.0	0.8	-0.4	1.0	0.5	-0.5	-0.9	-1.5	-0.3	0.0
Crohns Disease (2017)	0.6	1.2	4.9	1.1	0.9	0.4	0.6	0.6	-1.1	-0.7	1.7	1.1	0.7	2.2	-0.9
Irritable Bowel Disease (IBD)	0.9	2.2	5.6	1.0	0.7	1.8	1.5	1.4	-0.2	0.2	2.4	2.0	2.2	1.7	0.1
Ulcerative Colitis (UC)	1.4	2.7	7.9	0.5	0.3	2.4	1.7	1.8	0.6	0.9	2.0	2.3	2.8	0.9	1.0
Major Depression (MDD)	0.7	0.8	2.3	1.3	0.6	0.6	-0.5	0.0	-1.5	-0.8	1.4	1.0	1.1	0.4	-0.0
Reaction Time	0.1	0.3	1.0	0.3	0.7	0.0	-0.0	-0.8	-0.9	-0.2	0.1	-0.5	-1.0	-0.0	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.5	-0.2	0.1	-1.3	-1.6	-0.8	-1.2	-0.5	0.6	0.4	0.2	-0.4	-1.0
Breast Cancer	0.3	0.8	2.5	0.9	-0.3	0.5	-0.0	1.5	1.3	0.8	-0.2	-1.3	-1.6	-0.4	0.1
Ovarian Cancer	0.6	0.8	2.5	1.1	0.6	-0.3	1.1	-0.1	-0.6	-1.0	1.5	0.1	1.6	0.1	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.8	2.7	-0.3	-0.7	-1.1	-1.0	-1.1	-1.1	-1.7	0.3	-0.8	-0.2	0.0	-0.9
Bipolar Disorder (2011)	1.2	1.1	3.7	0.5	1.3	0.0	-1.3	-1.9	-1.2	-1.4	0.0	-0.0	0.9	-0.3	-1.4
Body Mass Index (BMI) (2010)	0.6	0.8	3.3	-0.4	-1.8	0.3	0.5	0.6	1.2	0.8	1.3	-0.0	-0.8	-0.6	0.7
Coronary Artery Disease (CAD)	0.5	0.6	2.2	0.4	1.5	1.2	-0.2	-0.4	-0.3	0.5	-0.5	0.9	1.1	0.4	0.4
Crohns Disease (2012)	0.9	1.5	5.3	-0.5	-0.2	-1.8	0.4	-0.5	-1.2	-2.3	0.8	-0.7	-0.2	1.3	-2.0
Mean Putamen Volume	1.6	1.8	9.5	1.4	1.4	-0.8	-1.0	-0.4	-3.1	-1.2	0.2	0.2	-0.4	1.9	-0.9
Fasting Glucose	0.1	0.2	0.6	-0.8	-0.2	0.6	0.1	0.5	0.3	-0.3	0.0	0.4	-0.5	-0.1	0.4
HbA1C	0.7	0.8	3.7	-0.2	-1.9	0.6	0.6	0.5	1.5	1.2	-1.1	0.2	-0.0	0.1	0.1
HDL Cholesterol	2.7	4.6	18.2	1.7	4.0	-1.1	-1.4	-2.5	-1.3	0.1	-2.2	4.3	-0.0	1.2	0.7
LDL Cholesterol	0.4	0.7	1.5	1.2	0.9	-0.6	-0.1	-1.0	1.1	0.4	-1.2	1.1	-0.5	-0.1	-0.0
Lupus	0.5	0.8	2.7	-0.8	0.2	0.2	-0.9	0.2	0.9	-0.7	-1.6	-1.0	-0.0	-1.6	0.6
Neuroticism (2016)	0.3	0.5	1.7	0.1	0.1	0.5	0.9	1.3	1.2	0.7	-0.3	-0.5	-0.7	0.3	0.1
Primary Biliary Cirrhosis	0.6	0.8	3.2	0.0	0.2	1.1	-0.1	0.0	0.9	1.7	-1.8	0.3	0.6	-0.8	0.6
Rheumatoid Arthritis	0.6	0.8	3.1	0.4	1.8	1.5	-0.2	-0.3	-0.4	-0.4	0.0	0.7	1.4	0.4	1.0
Schizophrenia (2014)	0.5	1.1	2.3	0.1	-0.2	1.3	1.4	1.5	0.3	1.2	0.7	1.2	0.8	1.0	1.4
Triglycerides	0.8	1.3	4.0	-0.1	0.9	0.9	-1.7	-2.0	-1.6	0.2	-1.3	1.3	1.3	-0.2	0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.3	-0.1	-0.6	0.5	1.2	0.4	-0.2	-0.7	-0.8	0.8	0.3	0.6	1.5
Ulcerative Colitis	1.6	2.4	6.8	-1.1	0.1	2.6	1.3	1.4	-0.1	0.5	1.4	2.3	2.5	0.8	1.6
Blood Eosinophil Count	0.3	2.0	6.0	2.0	0.9	1.0	1.4	1.3	1.9	2.4	1.6	0.5	0.7	-0.3	1.1
Blood Platelet Count	0.2	1.8	5.2	0.4	0.7	2.1	0.5	0.2	-1.3	-0.4	0.1	2.3	2.2	1.9	0.8
Blood Red Count	0.1	0.9	3.2	-0.1	1.5	-0.2	0.2	-1.0	-1.5	-1.8	-0.4	0.3	1.0	0.5	0.4
Blood White Count	0.2	1.1	4.6	1.1	-1.0	2.0	0.5	0.2	-1.1	-0.5	0.5	0.3	2.1	-0.2	0.9
Heel T-Score	0.1	0.7	2.1	-1.3	-0.7	-0.7	-1.4	-0.3	-0.7	-0.7	-1.4	0.3	-0.4	-0.6	-0.0
BMI	0.2	1.3	3.8	-0.8	-1.9	1.6	0.1	1.4	-1.3	-0.5	-0.6	-0.1	-0.5	0.9	1.9
Height	0.1	1.0	2.3	-1.5	-0.3	-0.6	-1.5	-1.0	-0.0	0.3	-1.5	-0.6	-1.0	-1.0	-1.1
Waist Hip Ratio (WHR)	0.9	4.2	26.6	-0.1	5.2	-0.6	-1.4	-2.8	-1.4	-1.6	-0.2	1.3	2.4	-1.2	-0.1
Systolic Blood Pressure	0.2	1.2	4.9	-0.9	-1.0	-1.1	-0.8	-1.3	-0.8	-2.2	0.1	0.9	1.5	-0.3	-0.1
Smoking Status	1.2	2.9	8.5	2.9	2.0	1.7	0.8	0.8	-1.3	1.0	2.2	1.4	1.3	2.5	0.8
Allergy or Eczema	0.2	0.7	2.8	1.0	0.0	0.4	0.7	0.3	-0.2	-0.1	1.3	0.7	1.7	0.9	-0.5
Cardiovascular Disease	0.1	0.3	1.4	0.5	1.2	0.4	-0.1	-0.3	-0.5	0.8	-0.6	-0.3	0.3	0.2	-0.3
Hypothyroidism (self reported)	0.9	2.0	4.4	0.2	-1.1	2.0	0.3	1.0	2.1	2.1	-0.3	1.1	1.4	-1.7	1.8
Respiratory disease	0.7	1.5	4.7	2.2	0.6	1.0	1.9	1.8	0.2	0.1	0.4	0.5	1.3	1.6	1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.1	-0.1	1.3	-0.5	-0.6	-0.2	-1.2	-1.5	0.7	-0.4	-0.0	0.0	-0.3
Lung FEV1/FVC ratio	0.9	4.7	14.2	-2.0	-0.0	-1.2	-3.8	-2.8	-0.9	-0.5	-3.6	-1.6	-0.5	-3.1	-1.5
Lung FVC	0.3	1.7	6.3	0.9	-0.7	-2.5	-0.9	-1.2	-0.6	-0.9	0.5	-1.4	-1.2	0.1	-2.3
Neuroticism	0.6	1.4	5.8	-0.7	-0.9	-2.4	0.0	-0.4	-0.8	-1.9	0.1	-1.0	-0.1	0.6	-1.9
Chronotype (morning person)	1.8	4.2	10.0	1.0	0.9	2.8	2.5	2.3	1.8	1.7	2.4	2.3	1.3	0.9	3.2
Hair Pigment	0.0	1.4	4.3	-0.4	0.9	-0.6	-1.2	-2.1	-1.9	-1.3	-0.7	-1.1	-0.5	-1.5	-0.2
Tanning	0.2	2.7	8.6	-0.1	-0.9	1.6	1.4	1.9	2.9	2.7	0.3	0.9	-0.6	-0.5	2.4
Hand grip strength (left)	0.2	0.4	1.5	1.2	1.0	1.0	-0.1	0.2	0.7	0.9	-0.0	0.1	-0.2	-0.4	-0.4
Number of treatments/medications taken	0.5	0.9	2.8	-0.1	-0.8	1.7	0.4	0.8	-0.3	1.6	-1.2	-0.2	1.1	-0.0	0.9
Average weekly spirits intake	0.2	0.2	1.0	-0.2	0.3	0.4	0.3	0.8	1.0	0.3	-0.0	0.3	0.1	0.3	0.1
Sensitivity / hurt feelings	1.0	1.7	5.4	-0.7	-0.9	-2.3	-1.0	-1.6	-1.2	-1.4	-0.2	-1.4	-1.5	-0.3	-1.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.7	-0.8	-0.1	-1.6	-1.0	-1.2	-1.4	-0.5	0.4	-1.1	0.2	-0.9	-1.4
Hearing difficulty/problems: Yes	0.7	1.1	3.1	-1.0	-1.6	-0.6	-1.3	-0.8	-0.7	-0.6	-1.8	-0.6	-0.1	-1.3	-0.5
Relative age of first facial hair	0.4	0.9	5.3	-0.7	-2.3	-1.1	-0.7	-0.2	0.4	-0.4	-0.3	-0.1	-0.9	-1.3	-0.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.9	-1.8	-1.6	-0.5	-0.1	0.4	-0.2	-0.9	-0.6	-1.3	-2.0	0.0	0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.8	-1.3	-0.7	-0.1	0.3	-0.5	1.1	0.8	-1.1	-0.6	0.2	-0.4	-0.4
Ever had hysterectomy (womb removed)	0.3	0.4	1.2	-0.6	-0.1	-0.7	0.7	-0.3	-0.0	-0.1	0.6	-0.7	-0.6	1.1	-0.9
Systolic blood pressure, automated reading	0.2	0.6	1.7	-0.4	-1.3	0.7	-0.7	-1.0	0.5	0.4	-0.2	0.7	1.3	-0.7	0.0
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	5.2	-0.3	-0.3	-1.5	-2.3	-1.4	-0.9	-0.2	-2.2	-1.4	-0.4	-1.6	-1.4
Angina	0.2	0.3	1.5	-1.0	1.2	-0.1	-0.0	0.2	-0.0	-0.5	-1.0	0.2	0.1	0.2	-0.3
Medication for hormone replacement therapy	1.5	1.7	8.8	-0.8	-1.1	1.0	0.8	0.7	3.0	2.2	0.4	-0.1	0.4	-1.1	0.7
Vitamin and mineral supplements	0.4	0.6	2.0	0.4	0.0	-0.1	-0.7	-0.7	-1.4	-1.2	0.2	-0.1	-1.0	1.1	-0.3
Supplements: Zinc	1.1	1.2	2.9	1.1	1.5	-0.8	0.7	-0.5	0.1	-0.3	1.0	0.7	1.6	1.5	-1.7
Medication: Co-codamol	0.6	0.6	2.3	-0.4	-0.8	-1.1	0.1	0.5	-0.9	-0.3	-1.5	0.1	-0.5	1.2	-0.7
Medication: Metformin	0.6	0.8	2.6	1.2	1.6	0.6	-0.2	0.0	-1.2	-0.5	1.2	0.4	1.0	0.5	0.5
Diabetes (father)	0.6	0.7	2.0	-0.1	-0.3	1.0	0.1	-0.3	1.4	1.2	-1.4	-0.2	0.8	-1.1	0.1
Diabetes (mother)	1.0	1.3	4.4	-0.5	0.0	2.1	-0.6	1.6	0.9	1.5	0.0	0.2	-0.3	-0.9	2.1
Severe depression (siblings)	0.2	0.3	1.7	-0.0	1.3	0.3	0.4	-0.7	0.2	-0.1	0.3	0.4	0.5	0.0	0.2
Pack years adult smoking proportion	0.5	0.7	2.3	-1.0	0.5	-0.4	-0.4	-1.5	-0.9	-1.3	1.2	-0.6	0.6	-0.4	0.2
Impedance of leg (right)	0.2	1.2	2.7	-0.8	0.8	-1.6	-0.2	-1.6	1.2	-0.5	-0.8	1.0	1.1	-0.8	-1.6
Leg fat-free mass (left)	0.2	1.2	3.4	0.0	-1.3	1.8	0.2	1.8	-1.1	0.2	0.9	-0.0	-0.2	1.0	1.6
Trunk fat percentage	0.3	1.1	6.1	-0.4	-2.5	1.2	0.1	1.2	0.3	0.1	-1.0	0.2	-0.2	0.1	1.6
Hand grip strength (right)	0.2	0.6	2.5	1.2	1.6	0.9	0.4	0.5	0.4	0.6	-0.2	0.8	-0.2	1.0	-0.1
Townsend deprivation index at recruitment	0.7	1.0	3.2	0.2	1.6	-1.6	-0.7	-1.8	-0.3	-0.4	-0.2	-0.7	0.3	-0.4	-1.5
Current tobacco smoking	0.6	0.9	2.7	0.8	-0.3	0.9	0.3	-0.2	-1.7	0.2	1.6	1.0	0.7	1.1	1.1
Average weekly fortified wine intake	0.6	0.7	2.8	0.1	-0.1	0.5	0.5	0.4	0.4	0.2	-1.1	-1.0	1.7	-0.6	-1.3
Maternal smoking around birth	0.3	0.4	0.8	0.9	-0.6	0.2	0.6	0.8	0.1	0.6	-0.6	-0.5	-0.9	0.7	0.2
Fed-up feelings	0.6	1.1	6.4	-0.5	0.1	-2.5	0.0	-0.1	-0.3	-0.6	1.1	-0.8	-0.7	0.7	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	3.3	0.7	0.4	-1.5	-1.0	-0.8	-1.5	-0.5	0.9	-0.7	0.1	-0.3	-1.8
Relative age voice broke	0.5	0.7	4.4	-0.1	-2.1	-0.2	-0.3	1.2	0.4	0.8	-0.6	0.0	-1.0	0.3	-0.2
Taking other prescription medications	0.6	0.9	2.5	-0.2	-0.9	1.1	0.9	1.2	1.1	1.3	-0.8	-0.1	0.0	-0.3	1.6
Age when periods started (menarche)	0.2	0.4	1.6	0.3	0.9	0.4	-0.1	-0.1	-0.6	0.7	0.7	1.3	0.7	0.4	0.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.0	0.8	-0.8	1.0	1.7	1.0	0.7	0.9	1.5	1.5	1.0	1.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.7	0.1	-1.2	1.3	-0.2	0.5	-0.8	0.5	-0.7	1.0	0.3	0.7	0.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	5.3	-0.3	0.2	1.4	1.3	2.3	0.5	1.4	0.0	0.7	1.0	1.0	1.1
Qualifications: CSEs or equivalent	0.1	0.2	0.6	0.5	0.1	0.2	-0.3	-0.3	-0.2	0.3	0.5	0.6	0.3	-0.4	0.8
Serious illness, injury or assault to yourself	0.8	0.9	3.7	0.4	0.1	-0.6	-1.9	-1.7	-1.5	-0.4	0.5	-0.1	-0.2	-0.5	-1.1
High blood pressure	0.4	1.0	5.2	1.2	0.4	0.8	1.2	0.1	-0.5	1.0	0.5	1.0	0.8	2.3	0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.0	-0.2	-0.5	-0.1	0.0	-0.4	-0.6	-0.7	1.4	-0.0	0.8	0.2	-0.5
Multivitamins +/- minerals	0.2	0.3	0.9	-0.4	0.2	-0.7	-0.1	-0.7	0.4	-0.0	-0.5	-0.4	1.0	-0.8	-0.5
Stomach or abdominal pain in last month	0.8	1.0	3.1	-1.1	-1.4	-0.6	-1.4	-0.8	-0.6	-0.3	0.0	-0.8	-1.8	-1.4	-0.5
Supplements: Glucosamine	0.5	0.7	2.5	-0.4	-1.3	-0.0	-0.2	0.3	0.4	0.0	-1.0	-1.1	-1.6	-0.6	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.6	-1.5	-0.1	-0.8	-0.7	-0.8	0.3	-0.7	-0.3	-0.4	-0.6	-1.6	0.8
Medication: Atenolol	0.2	0.3	1.5	0.3	0.9	-0.1	0.1	-0.1	-0.2	-0.6	0.2	-0.4	-1.2	0.0	0.8
Medication: Levothyroxine sodium	1.1	1.8	4.7	-0.5	-0.9	1.9	1.4	1.2	2.2	1.2	-0.2	1.7	1.0	0.2	1.9
Sitting height	0.1	0.5	1.7	-0.8	-0.1	-0.6	-0.9	-0.1	-0.2	-0.6	-1.3	-0.7	-0.7	-0.7	-0.1
Chronic bronchitis/emphysema (father)	1.3	1.6	3.4	-1.0	-1.8	-0.4	-1.7	-1.5	-1.3	-0.7	-0.8	-1.8	-0.1	-1.6	-0.6
High blood pressure (mother)	0.3	0.4	1.2	0.6	0.6	-0.1	-1.0	-0.6	-0.8	0.2	-1.1	0.4	0.9	-0.2	-0.2
Body mass index (BMI)	0.3	1.3	4.9	0.3	-1.6	2.1	0.2	1.6	-0.7	0.4	-0.1	-0.1	-0.3	0.8	2.2
Impedance of leg (left)	0.2	1.0	1.7	-0.6	1.2	-1.2	-0.1	-1.3	1.3	-0.0	-1.1	0.8	0.9	-0.7	-1.3
Leg predicted mass (left)	0.2	1.1	3.3	0.0	-1.3	1.8	0.3	1.7	-1.1	0.1	1.0	-0.1	-0.2	1.0	1.6
Trunk fat mass	0.3	1.1	5.2	-0.6	-2.3	1.5	-0.0	1.2	0.1	0.3	-0.9	0.0	-0.4	0.1	1.8
Waist circumference	0.1	0.4	1.7	-0.5	0.2	0.9	-0.7	0.0	-0.9	-0.3	-0.2	-0.0	-0.1	-0.1	1.3
Number of incorrect matches in round	1.3	2.1	5.6	-1.4	-0.6	-1.9	-1.5	-1.5	-0.6	-1.6	-0.9	-2.4	-1.4	-1.3	-1.3
Past tobacco smoking	0.6	1.1	4.0	-1.4	-2.0	-0.2	1.0	0.8	-0.2	-1.7	0.1	0.9	0.1	0.5	1.3
Alcohol usually taken with meals	0.5	0.9	3.4	-0.5	-1.3	-0.5	-1.1	-1.7	-0.5	-0.1	0.0	-0.2	-0.3	-0.3	-1.9
Nervous feelings	0.2	0.4	1.7	-1.2	-1.3	-0.2	0.3	0.6	-0.1	-0.0	0.0	-0.3	-0.6	0.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	5.9	-0.6	-1.5	-2.2	-1.5	-0.9	-0.6	-0.8	-0.4	-2.4	-1.6	-0.8	-2.4
Hearing difficulty/problems with background noise	0.2	0.2	2.0	0.4	1.4	-0.4	-0.3	0.0	-0.5	0.1	0.4	-0.1	0.1	-0.1	-0.4
Hair/balding pattern: Pattern 2	1.5	1.9	4.6	-0.6	-0.3	1.9	0.4	1.5	0.9	1.8	2.1	2.0	1.2	0.3	1.4
Had menopause	1.4	1.8	3.8	-1.2	-0.8	-0.8	-1.9	-1.2	-1.0	-0.5	-1.8	-2.0	-1.8	-0.7	-1.3
Had other major operations	0.8	0.9	2.7	-0.7	-1.5	-0.5	-1.3	-0.9	-0.0	0.1	-0.1	-1.6	-1.2	-1.1	-0.7
Forced vital capacity (FVC)	0.1	0.6	1.9	1.4	0.5	0.0	1.0	0.5	0.9	1.0	0.7	0.6	0.3	0.6	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.6	0.1	-0.6	1.3	-0.6	0.6	-1.9	0.0	-0.7	1.3	0.2	1.1	1.1
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	5.6	1.7	0.4	-1.6	-0.2	-1.2	0.1	-0.2	-0.3	-1.6	0.6	-0.4	-2.4
Qualifications: None of the above	0.4	0.8	4.6	0.0	-2.1	0.4	-0.7	-0.5	0.7	0.7	-0.2	-0.6	-0.4	-1.3	0.5
Financial difficulties in last 2 years	0.6	0.8	1.7	1.0	1.3	0.7	0.8	0.5	-0.3	0.9	0.5	0.2	1.1	1.1	-1.2
Mouth/teeth dental problems	3.4	5.3	11.2	2.1	1.1	2.8	3.3	2.0	2.1	1.8	1.0	3.1	2.9	1.9	1.9
Heart attack	0.7	0.9	2.2	1.3	1.5	-0.6	-0.8	-1.3	-0.3	-0.0	-1.2	-0.5	0.2	0.1	-1.5
Allergy	0.2	0.4	2.6	-0.3	0.6	-0.0	-0.8	-0.1	-0.1	0.1	-1.6	-0.3	-0.8	-0.6	-0.3
Pain all over the body in last month	1.9	2.0	5.1	0.8	-0.1	-1.3	-1.2	-0.9	-1.9	-1.7	1.5	-2.1	-0.8	0.6	-2.2
Diabetes (self-reported)	0.7	1.1	1.8	-0.2	1.2	-1.1	-1.3	-1.1	-1.2	-1.3	-0.0	-1.1	-0.2	-0.7	-1.3
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	8.1	1.3	0.8	1.7	1.8	2.4	-0.3	0.4	2.2	2.9	1.0	2.8	2.0
Medication: Ramipril	1.8	2.4	5.7	-0.8	1.2	-1.4	-2.4	-2.2	-1.9	-1.7	-1.1	-1.0	0.1	-1.4	-1.8
Medication: Simvastatin	0.9	1.3	5.8	-0.3	-0.1	0.0	-1.3	-1.1	0.4	1.0	-2.4	-0.9	0.2	-2.2	-0.2
Fluid intelligence score	0.3	0.7	3.1	0.7	-0.1	-1.0	-1.3	-0.9	-1.8	-0.7	-0.0	0.2	0.3	-0.2	-0.9
Illnesses of siblings	0.6	0.8	4.3	-0.2	1.1	0.2	0.6	0.6	-1.1	-0.9	0.5	0.5	-0.6	2.1	-0.0
Neuroticism score	1.0	2.1	7.5	-1.2	-1.3	-2.7	-0.5	-1.1	-1.0	-1.3	0.2	-2.0	-0.8	0.2	-2.3
Weight	0.2	1.1	4.1	-0.2	-1.5	2.0	0.1	1.5	-0.4	0.6	-0.2	0.1	-0.3	0.6	2.0
Impedance of arm (right)	0.2	0.9	2.5	-0.3	-1.2	-1.3	-0.2	-1.0	1.6	-0.1	-1.0	0.8	0.5	-1.1	-1.2
Arm fat percentage (right)	0.3	1.3	8.5	-0.5	-2.9	1.2	-0.2	1.0	0.0	0.1	-0.8	-0.2	-0.5	-0.0	1.9
Trunk fat-free mass	0.1	0.6	2.4	-0.5	-0.1	1.5	-0.1	0.9	-0.8	0.6	1.0	-0.4	-0.4	0.2	1.2
Hip circumference	0.3	1.2	3.8	-0.1	-1.9	1.4	0.2	1.9	-0.4	0.5	0.3	-0.1	-0.8	1.0	1.7
Time employed in main current job	0.3	0.4	2.3	-0.6	-1.5	-0.3	-0.3	0.2	0.4	-0.9	-0.2	-0.2	-0.4	-0.6	0.6
Alcohol intake versus 10 years previously	0.4	0.6	3.3	-0.6	0.5	0.2	0.4	0.2	-1.0	0.2	-1.8	-0.4	-0.2	0.4	1.5
Father’s age at death	1.4	1.9	7.7	-0.8	-0.3	-0.1	2.1	1.9	2.8	0.7	0.8	0.9	-1.4	0.7	1.2
Worrier / anxious feelings	0.1	0.3	1.2	0.7	0.2	0.5	0.4	0.1	-0.3	1.1	0.4	-0.6	0.6	0.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.4	-0.4	-1.6	-0.3	-0.8	-0.2	-0.3	0.2	-1.0	-1.0	-0.4	-1.5	-0.5
Falls in the last year	0.3	0.4	1.7	-1.3	-0.5	-0.4	-0.2	0.7	-0.3	-0.4	0.6	0.1	-1.2	0.3	0.6
Hair/balding pattern: Pattern 3	0.7	1.1	4.0	0.6	-0.1	-0.9	-0.2	0.0	0.2	0.7	-2.0	-1.6	-1.9	-0.9	-0.3
Number of live births	0.2	0.3	2.4	-0.8	-1.5	0.8	-0.2	0.4	0.0	-0.0	0.4	-0.1	-0.2	-0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.4	1.2	0.5	0.3	0.6	0.4	0.8	1.1	-0.6	0.7	0.2	0.2	0.2
Pulse rate	1.3	2.2	5.3	-1.6	-0.4	-2.1	-1.5	-1.2	1.2	-0.6	-0.7	-2.0	-0.4	-2.3	-2.1
Happiness	0.6	0.7	2.3	0.1	-0.6	-1.0	-0.4	-0.4	0.9	0.6	1.5	-0.9	-0.4	-1.4	-0.6
Noisy workplace	0.3	0.4	1.2	-1.1	-0.5	-0.5	-0.7	0.4	-0.1	-0.5	0.1	-0.9	-0.3	-0.8	-0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.1	1.5	0.9	1.2	1.2	0.6	-0.4	0.1	0.5	1.2	1.4	1.8	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.7	-0.4	-0.7	-0.6	-0.0	0.1	0.8	0.4	0.1	-0.4	-0.6	-0.4	-0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	2.7	-1.3	-0.8	-0.6	-0.2	-0.5	-0.9	-1.0	-1.1	-1.6	-0.8	0.3	-0.9
Asthma	0.3	0.6	2.1	1.3	-0.2	0.4	1.5	0.6	0.7	0.2	0.1	0.1	0.7	1.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.5	0.3	0.2	0.2	0.1	0.9	-0.9	0.4	0.6	0.9	1.2	1.2	-0.9
Medication: Cholesterol lowering	1.1	1.6	4.6	0.4	0.7	-0.2	-1.7	-1.7	0.4	0.9	-2.1	-1.5	-0.2	-2.1	-0.7
Depression (self-reported)	0.8	0.9	2.2	-0.4	1.4	-1.3	-0.8	-0.0	-1.1	-0.7	0.0	-1.4	-1.5	-0.2	-0.7
Medication: Lansoprazole	0.3	0.4	2.5	0.2	0.4	0.2	-0.4	-0.6	-1.6	-0.0	-0.4	0.5	0.5	0.8	-0.2
Prospective memory result	0.6	0.8	3.3	-0.4	0.0	1.0	1.8	0.6	0.3	0.2	0.8	-0.1	-0.2	1.8	0.7
Lung cancer (father)	0.5	0.6	3.3	-0.8	0.1	-0.1	0.6	1.8	0.5	0.4	1.1	0.4	-0.7	0.5	0.5
Illnesses of mother	0.8	1.0	2.6	0.7	1.4	0.8	1.3	0.0	-0.4	0.0	1.5	1.3	1.1	1.6	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.8	0.9	0.1	0.3	0.4	-0.2	0.6	0.6	0.2	0.2	0.4	-0.3	-0.1
Pulse wave Arterial Stiffness index	1.0	1.1	3.1	1.4	0.5	1.3	1.0	-0.2	0.6	1.4	0.4	1.7	1.2	0.8	1.0
Impedance of arm (left)	0.1	0.7	2.6	0.0	-1.2	-0.9	0.3	-0.3	1.6	0.2	-0.2	1.2	0.8	-0.5	-0.8
Arm fat mass (right)	0.3	1.4	5.7	-0.4	-2.4	1.8	0.2	1.5	-0.1	0.3	-0.6	-0.0	-0.4	0.4	2.1
Trunk predicted mass	0.1	0.6	2.1	-0.7	-0.1	1.5	-0.3	0.8	-0.8	0.6	0.9	-0.5	-0.5	0.1	1.1
Standing height	0.0	0.2	0.9	-1.0	0.0	0.2	-0.1	-0.0	0.8	0.6	-0.4	0.3	0.3	-0.6	-0.4
Length of working week for main job	1.1	1.2	3.2	0.9	1.1	1.2	0.4	0.4	-1.1	1.1	1.7	1.2	1.8	0.7	0.4
Exposure to tobacco smoke at home	0.9	1.0	2.8	-0.2	1.7	1.5	0.2	0.7	-1.0	0.6	0.9	1.0	0.3	0.8	1.4
Breastfed as a baby	2.3	2.8	5.8	-2.2	0.0	-1.7	-2.2	-2.2	-0.1	-0.6	-1.2	-2.0	-1.5	-2.4	-1.4
Tense / ‘highly strung’	0.2	0.3	1.0	-0.6	-0.2	-0.7	-0.4	0.2	-0.2	0.6	-0.3	-0.8	-1.0	0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.4	0.1	0.1	-1.2	-0.3	-1.1	-1.4	-1.6	-0.3	-1.0	-0.1	0.5	-0.9
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	0.8	-0.3	-0.6	-0.5	-0.9	-1.0	-1.1	-0.2	0.0	0.3	0.3	-0.3
Birth weight of first child	1.0	1.8	7.4	0.9	2.7	-0.9	0.3	-1.0	-0.2	-2.0	0.7	-0.2	2.0	-0.0	-1.7
Peak expiratory flow (PEF)	0.2	0.4	1.5	0.3	0.2	-0.2	0.5	0.2	1.2	1.1	-0.8	0.8	-0.2	-0.3	0.5
Pulse wave reflection index	1.8	2.2	6.0	1.8	0.5	1.6	1.9	0.7	1.2	1.1	1.1	2.4	0.9	1.1	2.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.3	0.9	-0.4	0.9	1.8	1.5	1.8	1.4	0.7	-0.2	-0.1	0.3	0.6
Loud music exposure frequency	0.7	0.8	3.9	-2.0	0.0	-0.6	-0.7	-0.3	-1.7	-0.7	-0.0	0.2	-0.5	0.3	0.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.0	0.4	0.6	1.8	1.0	2.2	-0.4	0.6	0.9	0.9	0.7	1.1	1.2
Mouth/teeth dental problems: Bleeding gums	5.0	6.4	19.4	-1.9	0.4	-2.6	-4.4	-3.2	-2.2	-1.1	-3.1	-2.7	-2.4	-2.1	-2.1
Blood clot in the leg (DVT)	0.6	0.8	2.7	-0.1	-1.6	-0.2	0.8	0.9	0.9	-0.3	1.4	0.3	-0.9	1.2	0.6
Medication: Paracetamol	1.0	1.6	6.3	1.1	-2.0	0.5	1.7	2.5	0.1	0.0	0.7	0.2	0.2	2.0	-0.2
Headache pain in last month	0.7	1.2	5.5	-0.7	-1.1	-0.9	-0.3	0.0	2.1	0.3	-0.4	-1.2	-0.2	-2.4	-0.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	6.3	-1.2	-0.5	1.3	1.9	2.5	1.1	0.2	2.0	1.8	0.0	1.4	2.1
Glaucoma (self-reported)	0.7	0.9	4.1	-0.6	-2.0	-0.0	1.0	0.9	0.9	-0.0	-0.7	0.3	-1.4	0.4	0.7
Gout (self-reported)	0.4	0.5	2.3	0.4	1.3	1.5	0.2	0.2	-1.0	0.6	-0.4	0.1	0.2	0.6	0.6
Hypothyroidism/myxoedema (self-reported)	2.0	3.8	8.4	0.9	-0.6	2.9	2.3	2.1	2.7	2.3	0.7	2.1	2.1	0.5	2.1
Medication: Amlodipine	0.3	0.4	1.5	-0.3	-0.2	-0.5	0.9	-0.1	1.0	-0.4	-1.2	-0.1	1.1	-0.4	0.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	0.5	0.8	0.7	0.6	0.5	0.7	0.8	-0.4	0.3	1.1	0.1	0.4
Birth weight	1.2	2.7	7.8	-0.9	-0.6	-1.6	-2.6	-0.8	0.9	0.1	-0.8	-2.0	-2.8	-2.7	-1.0
Chronic bronchitis/emphysema (mother)	1.6	1.9	6.9	-1.5	0.3	-1.3	-0.5	-1.3	-0.9	-1.2	-2.6	-1.9	-0.7	-0.0	-2.1
High blood pressure (siblings)	0.8	1.1	3.2	-0.1	-1.8	-1.1	-1.5	-1.2	0.1	0.4	-1.0	-0.8	-0.4	-1.6	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.9	2.1	1.4	-0.0	0.4	1.4	0.5	1.3	1.3	1.4	0.5	0.5	0.2	0.4
Body fat percentage	0.2	1.0	4.8	-0.1	-2.2	1.3	0.2	1.1	0.1	0.0	-0.9	0.2	-0.1	0.4	1.6
Leg fat percentage (right)	0.2	0.6	2.4	-0.0	-1.5	1.1	-0.2	0.7	-0.3	-0.3	-0.7	0.1	-0.2	0.3	1.3
Arm fat-free mass (right)	0.1	0.7	1.8	-0.7	-0.3	1.3	-0.2	1.0	-1.2	-0.1	1.1	-0.7	-0.5	0.5	1.1
Exposure to tobacco smoke outside home	0.2	0.3	1.4	-0.1	-0.2	-0.0	0.4	-0.6	-0.6	-0.4	1.2	0.7	0.4	0.6	0.3
Comparative body size at age 10	0.1	0.2	1.0	0.5	0.1	0.3	-0.5	-0.3	-0.5	-0.5	1.0	-0.5	0.1	0.2	-0.2
Number of full brothers	0.8	1.0	3.4	0.8	-0.1	1.3	1.0	0.8	1.8	1.2	-1.0	-0.1	0.6	-1.1	1.0
Worry too long after embarrassment	0.6	0.9	2.9	-0.0	-1.3	-1.5	0.0	-0.6	-1.4	-1.7	0.3	-0.6	-0.1	0.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	5.9	-2.2	-1.1	-1.3	-1.6	-2.3	-2.0	-1.6	-2.4	-2.2	-1.3	-1.6	-1.1
Wheeze or whistling in the chest in last year	0.8	1.4	3.7	1.3	-0.4	1.4	1.3	1.3	0.7	1.7	1.9	-0.0	0.2	1.0	1.2
Number of children fathered	0.4	0.4	2.1	1.5	-0.5	0.2	0.7	-0.2	0.0	0.1	-0.5	-0.9	-0.8	0.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	5.4	-1.4	0.3	0.1	-0.3	-0.9	1.6	0.4	-1.3	0.0	0.8	-2.3	0.1
Age at first live birth	2.7	4.7	8.2	-2.3	-0.2	-2.8	-2.9	-2.3	-1.2	-2.7	-2.7	-1.7	-0.9	-2.3	-2.2
Pulse wave peak to peak time	1.1	1.3	3.3	-1.5	-0.3	-1.4	-1.2	-0.0	-0.8	-1.5	-0.4	-1.8	-1.1	-1.0	-1.1
Health satisfaction	0.3	0.4	1.5	-0.6	0.7	0.6	0.7	-0.6	0.6	0.5	-0.3	-0.1	0.6	-0.5	1.2
Shortness of breath walking on level ground	0.4	0.5	1.7	0.1	0.5	1.0	0.8	0.5	0.0	0.0	1.3	0.3	0.5	0.5	0.9
Qualifications: College or University degree	1.1	3.3	6.1	1.9	2.0	-0.7	0.9	-0.9	-2.4	-2.3	2.1	1.3	2.1	2.5	-1.7
Eye problems/disorders: None of the above	0.5	0.5	2.7	-0.4	0.0	-0.1	-0.6	-0.4	0.7	0.0	-0.4	-1.4	0.3	-1.7	-0.7
Mouth/teeth dental problems: Loose teeth	3.6	4.3	13.5	-1.3	-0.4	-2.2	-3.7	-2.7	-2.1	-1.7	-0.6	-1.9	-1.4	-2.3	-2.3
Emphysema/chronic bronchitis	2.5	2.8	6.6	-0.3	0.3	2.2	1.7	2.1	0.8	2.2	0.6	2.1	0.4	1.9	2.6
Medication for pain relief, constipation, heartburn	0.6	1.0	3.9	-0.5	-0.4	-0.6	-1.1	-1.0	0.9	0.4	0.5	-0.3	-2.0	-1.6	0.7
Neck or shoulder pain in last month	0.3	0.4	1.5	0.1	0.7	0.5	-0.4	-0.6	-0.9	1.2	0.0	1.1	0.5	0.2	0.3
Medication: Blood pressure	0.7	1.3	4.6	0.8	0.2	-1.3	-1.2	-2.1	-1.0	-0.4	-0.9	-1.0	0.2	-0.7	-1.8
Angina (self-reported)	0.2	0.3	1.3	-0.8	1.1	0.1	0.2	0.3	0.3	-0.0	-0.8	0.4	0.1	0.4	0.0
Migraine (self-reported)	0.8	1.0	2.8	-1.2	0.1	-1.5	-0.6	-0.7	-0.3	-1.7	-1.3	-0.8	-1.2	-0.2	-0.7
Medication: Ibuprofen	0.8	0.9	2.9	0.3	-0.4	1.1	0.6	1.2	0.1	1.4	0.1	1.5	1.7	0.8	0.0
Medication: Allopurinol	0.5	0.6	2.7	-0.5	0.9	0.6	-0.9	-0.5	-0.7	0.4	-1.6	-0.9	-1.0	-0.1	-0.1
Medication: Omeprazole	0.5	0.5	4.7	-0.2	-0.5	0.8	0.2	-0.1	-0.4	-0.0	-2.2	-0.6	0.3	0.3	0.1
Medication: Seretide 50 evohaler	1.4	1.6	5.0	-0.4	-2.2	1.0	2.0	1.9	1.7	0.6	0.8	-0.5	-0.4	0.4	1.1
Mean time to correctly identify matches	0.2	0.5	2.3	-0.5	-0.3	-0.3	-0.2	-0.8	-0.7	-0.2	-0.6	-1.0	-1.5	-0.1	0.1
Heart disease (mother)	0.5	0.6	2.4	-1.1	-1.1	-0.4	-1.3	-0.6	-0.3	0.4	-0.3	-0.3	-0.2	-1.5	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	4.5	-0.9	-0.5	0.3	0.1	1.5	2.1	0.8	0.1	0.1	-0.6	-1.0	0.3
Whole body fat mass	0.3	1.1	4.3	-0.3	-2.1	1.7	0.1	1.3	-0.1	0.2	-0.6	0.0	-0.4	0.5	1.9
Leg fat mass (right)	0.3	1.0	4.0	-0.3	-2.0	1.6	-0.1	1.2	-0.4	-0.0	-0.7	-0.0	-0.3	0.5	1.7
Arm predicted mass (right)	0.2	0.8	2.4	-0.6	-0.1	1.6	-0.2	1.0	-1.2	0.2	1.1	-0.6	-0.5	0.6	1.3
Pulse rate, automated reading	0.4	1.2	4.2	-1.8	-1.8	-0.4	-1.3	-0.9	0.5	0.2	-0.1	-0.1	-0.4	-2.0	0.2
Alcohol intake frequency.	0.2	0.5	1.3	-0.4	-1.1	0.0	-0.3	1.1	-1.1	-0.4	0.3	-0.4	-0.9	0.5	0.8
Comparative height size at age 10	0.1	0.8	4.8	-2.2	-0.2	-0.3	-0.5	-0.0	0.3	0.2	-0.7	-1.4	-0.8	-0.9	-0.6
Number of full sisters	1.4	1.7	7.0	-1.0	-0.9	-0.8	-2.6	-0.5	-1.1	-0.2	-0.5	-1.9	-1.1	-1.8	-1.1
Suffer from ‘nerves’	0.6	0.9	2.8	-0.8	-1.0	-1.7	-0.9	-0.0	-0.0	-0.6	0.5	-1.5	-0.8	-0.1	-1.4
Overall health rating	0.4	0.9	3.2	-0.7	-1.3	0.2	-1.0	-0.0	0.2	1.8	-0.4	-1.3	-1.3	-1.1	0.3
Chest pain or discomfort	1.1	1.6	4.3	1.1	2.1	1.2	1.7	1.9	0.8	0.3	1.3	0.0	1.0	1.4	0.8
Had major operations	2.1	2.5	5.3	-2.3	-0.7	-1.4	-2.3	-1.5	-0.5	-0.3	-1.3	-1.8	-2.3	-2.2	0.1
Age at last live birth	0.5	0.7	1.8	-0.3	1.0	-0.3	-0.9	-1.2	-0.7	-1.3	-0.9	-0.2	0.6	-1.1	-0.8
Family relationship satisfaction	1.0	1.3	4.2	-0.3	-1.3	-0.8	-0.9	-1.6	-0.7	-0.0	-0.5	-2.0	-0.9	-1.6	-1.2
Leg pain on walking	0.9	1.1	3.9	-2.0	-0.6	-0.3	-0.5	-0.3	-1.5	-1.5	-0.2	-1.2	-1.5	0.2	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.9	-0.1	0.6	0.8	0.4	1.4	0.4	0.4	-0.7	0.0	-0.5	-0.0	0.9
Commuting to job workplace: Car/motor vehicle	1.3	1.5	7.4	0.2	-1.1	1.2	1.4	1.6	1.6	-0.0	0.2	0.9	-0.1	-0.2	2.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	-1.0	-0.3	-0.1	-0.8	-1.0	-0.6	-1.2	-1.0	-0.5	0.2	-1.0	0.4
Medication: Aspirin	0.6	0.8	2.3	-0.4	0.7	-0.5	-0.5	-1.5	-1.0	-1.1	-1.0	-1.1	0.8	0.0	-0.9
Supplements: Vitamin C	0.9	1.0	2.8	1.0	0.7	0.7	1.7	1.4	1.5	1.4	0.6	0.7	0.6	0.6	0.4
Knee pain experienced in last month	1.0	1.6	10.9	-1.7	-3.3	-1.0	-0.7	0.0	0.0	-0.5	-0.1	-1.2	-1.3	-0.6	-0.5
Hypertension (Self-reported)	0.3	0.9	4.2	1.2	0.3	0.9	1.0	-0.0	-0.6	0.8	0.4	0.9	0.9	2.0	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.2	0.8	0.5	1.1	0.1	-0.1	0.1	0.9	-1.5	0.3	1.2	0.2	0.6
Illnesses of father: Heart disease	0.3	0.5	1.7	1.3	1.3	0.5	0.6	-0.0	0.3	0.3	0.5	0.3	0.8	0.4	-0.3
Illnesses of siblings: Diabetes	0.7	0.8	3.3	1.2	0.7	1.5	-0.1	-0.7	-0.5	0.7	-1.0	-0.3	1.8	-0.3	-0.2
Smoking status: Previous	0.6	0.9	3.3	1.8	1.8	0.3	-0.7	-0.7	-0.1	1.2	-0.6	-0.3	0.5	0.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.6	1.4	1.7	2.0	0.4	0.4	-1.0	2.1	1.1	1.8	2.1	0.8	0.9
Whole body fat-free mass	0.1	0.8	2.8	-0.5	-0.6	1.7	-0.1	1.2	-1.2	0.3	1.0	-0.5	-0.4	0.6	1.3
Leg fat-free mass (right)	0.2	1.3	4.1	0.2	-0.8	2.0	0.5	2.0	-1.1	0.4	0.9	-0.1	-0.2	1.1	1.7
Arm fat percentage (left)	0.3	1.3	7.8	-0.1	-2.8	1.4	0.1	1.4	-0.0	0.2	-0.2	0.1	-0.3	0.3	1.9
Average weekly red wine intake	1.2	1.8	5.3	1.4	0.8	-0.8	-0.8	-2.3	-1.2	-2.3	-0.2	-0.4	1.4	-0.2	-1.8
Handedness (chirality/laterality): Left-handed	0.6	0.7	4.7	-0.0	1.2	-0.0	-0.0	-0.2	0.1	0.4	0.4	0.9	2.2	-0.4	-0.8
Mood swings	0.5	1.0	2.5	-1.5	-1.5	-1.6	0.4	-0.5	-0.3	0.2	0.3	-1.3	-0.9	-0.1	-1.2
Loneliness, isolation	1.2	1.7	4.9	-1.4	-0.5	-2.2	-1.0	-0.5	-0.2	-0.7	0.2	-2.0	-1.9	-1.1	-1.4
Long-standing illness, disability or infirmity	1.1	1.6	4.3	-2.1	-1.1	-1.8	-1.6	-0.6	-0.1	-0.8	-1.4	-1.4	-1.2	-1.5	-0.5
Ever had bowel cancer screening	0.8	1.0	3.1	-1.4	-1.8	-0.8	1.2	-0.4	0.8	0.1	-0.7	0.6	-0.8	0.4	1.4
Diabetes diagnosed by doctor	0.5	0.9	2.4	0.0	1.3	-0.7	-0.9	-0.5	-1.4	-1.5	0.3	-0.9	0.6	-0.2	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.2	-1.1	-0.7	-0.4	-0.9	-1.0	0.1	0.1	-1.0	-1.5	-0.9	-0.7	-0.9
Friendships satisfaction	0.4	0.5	2.7	-0.1	-0.2	0.2	0.9	0.6	0.8	1.7	0.7	-0.7	-0.5	-0.4	0.6
Qualifications: nursing, teaching	0.6	0.9	3.4	-0.4	0.7	-0.8	-0.5	-0.7	-1.7	-1.8	0.8	-0.4	0.5	0.4	-1.2
Commuting to job workplace: Walk	0.5	0.5	1.7	-0.7	1.3	0.0	-0.9	-0.1	-1.2	0.7	-0.1	-0.3	0.3	-0.0	-1.0
Eye problems/disorders: Cataract	0.8	1.0	5.8	1.1	0.7	0.3	1.2	0.4	-0.8	-0.7	0.5	1.0	0.6	2.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.4	-0.4	-1.9	-1.3	-0.7	-0.0	-1.2	-0.7	1.2	0.3	-1.3	-0.2	0.1
Medication for cholesterol	0.8	1.2	2.9	0.3	0.2	-1.7	-1.3	-1.0	-1.6	-1.6	0.2	-0.8	-1.3	0.1	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.9	0.6	0.8	1.7	1.6	1.4	1.6	1.4	-0.4	1.1	1.6	0.4	1.4
Back pain experienced in last month	0.2	0.3	1.6	0.6	-0.3	0.3	-0.1	0.2	0.3	0.8	-1.3	-0.0	0.2	-0.8	0.2
Mineral and other dietary supplements	0.6	0.8	2.5	-0.9	-1.6	-0.2	-1.6	-0.9	-1.0	-0.2	-1.0	-0.1	-0.3	-0.5	-0.8
Breast cancer (self-reported)	0.7	0.8	2.8	-1.7	0.8	-0.9	-0.9	-0.3	-0.7	-1.3	-0.5	0.5	-0.9	-0.3	0.9
Asthma (self-reported)	0.3	0.6	2.1	1.4	-0.1	0.5	1.2	0.6	0.8	0.4	-0.0	0.2	0.7	0.7	0.8
Osteoporosis (self-reported)	0.2	0.3	0.9	0.5	0.9	0.5	0.6	0.3	0.7	0.2	0.1	0.7	0.4	-0.1	0.6
Osteoarthritis (self-reported)	1.5	2.0	10.5	-1.0	-3.2	1.7	1.2	2.2	-0.1	0.5	-0.6	-0.6	-0.8	0.9	1.0
Medication: Aspirin	0.7	0.9	2.7	-0.1	1.0	-0.4	-0.5	-1.6	-0.8	-1.1	-0.7	-0.9	1.5	-0.2	-1.0
Medication: Gliclazide	0.8	0.9	3.4	-0.8	0.6	-0.5	-1.2	-0.5	-0.8	-1.0	-0.0	-1.8	0.3	-1.0	-1.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	-0.8	-0.6	0.2	0.7	0.6	0.8	0.3	0.6	0.1	-0.2	0.2	0.7
Smoking status: Current	0.5	0.8	3.0	0.4	-0.1	1.1	0.4	-0.0	-1.3	0.5	1.7	0.9	0.5	0.8	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	-0.2	-0.3	-0.3	0.0	-0.4	-0.4	-0.5	-0.5	0.1	0.1	-0.1	-0.3
Whole body water mass	0.1	0.7	2.3	-0.5	-0.5	1.5	-0.3	1.1	-1.2	0.3	0.9	-0.5	-0.5	0.4	1.2
Leg predicted mass (right)	0.2	1.3	4.1	0.2	-0.8	2.0	0.5	2.0	-1.1	0.5	0.9	-0.2	-0.2	1.1	1.7
Arm fat mass (left)	0.3	1.4	5.8	-0.5	-2.4	1.8	0.1	1.5	-0.3	0.3	-0.3	-0.0	-0.5	0.5	2.1
Number of self-reported non-cancer illnesses	0.2	0.4	2.0	0.2	0.3	0.8	1.0	0.1	0.3	1.4	-0.3	-0.1	0.5	0.7	0.5
Average weekly champagne plus white wine intake	0.5	0.7	2.1	0.1	0.5	-0.8	0.3	-0.9	1.5	-0.6	-1.2	-0.5	0.7	-0.9	-1.1
Miserableness	0.8	1.4	6.2	-1.2	-0.4	-2.5	0.8	-0.1	0.2	-0.5	0.9	-1.8	-1.2	0.4	-1.6
Guilty feelings	0.9	1.3	4.5	0.8	1.2	0.1	1.0	0.4	-1.2	-0.4	1.8	1.2	1.4	2.1	0.3
Wears glasses or contact lenses	1.1	1.3	4.0	0.0	0.1	-1.4	-0.8	-1.9	-0.9	-1.9	-0.5	-0.5	0.4	0.4	-2.0
Ever taken oral contraceptive pill	0.9	1.0	2.5	0.7	1.2	0.4	0.4	-0.6	-1.0	-0.2	-1.6	0.3	1.6	1.2	-1.2
Hearing aid user	0.8	0.9	2.6	1.3	0.6	0.1	1.3	1.6	0.4	0.4	0.1	0.8	-0.5	1.5	0.6
Mother’s age at death	0.6	0.7	2.1	-1.1	-1.1	-1.0	-0.1	-1.0	-0.1	-1.0	0.1	-1.4	-0.8	-0.7	-0.5
Financial situation satisfaction	0.6	0.8	2.5	1.1	-0.1	1.6	0.9	1.2	0.6	0.6	0.4	0.2	1.2	0.6	0.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	6.3	-0.7	-2.5	-0.0	-0.4	0.1	0.9	1.1	0.3	-0.1	0.2	-1.4	0.2
Commuting to job workplace: Public transport	1.2	1.5	6.1	1.1	2.5	0.2	0.5	-0.4	-0.8	-0.0	1.2	0.6	1.8	1.5	-1.5
Eye problems/disorders: Glaucoma	0.8	1.0	2.3	-0.8	-1.5	0.8	0.4	1.1	0.8	1.3	-0.9	0.8	-1.0	0.3	1.3
Medication: Blood pressure	0.1	0.2	0.9	0.2	0.1	-0.1	-0.1	-0.3	-0.9	-0.4	0.3	0.2	0.2	0.7	-0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.7	-0.6	-1.4	0.4	0.2	0.9	1.6	1.4	-1.1	-0.2	0.2	-1.1	-0.3
Supplements: Fish oil (including cod liver oil)	1.5	2.0	5.1	1.6	2.1	1.1	2.3	1.6	1.0	0.4	1.9	0.5	0.8	1.0	1.1
High cholesterol (Self-reported)	0.8	1.5	4.9	-0.0	0.7	0.7	0.0	-1.6	1.1	2.2	-2.1	0.4	0.9	-1.4	0.7
Medication: Bendroflumethiazide	1.0	1.6	4.9	0.0	-1.0	-1.1	-2.2	-1.8	-1.4	-0.4	-0.3	-0.8	-0.8	-1.2	-1.9
Medication: Paracetamol	0.8	1.3	5.4	0.1	-1.9	0.5	1.3	2.3	-0.3	0.0	0.4	0.4	0.3	2.0	0.0
Medication: Lisinopril	0.3	0.4	1.3	-0.5	-0.5	0.7	1.1	0.8	0.8	0.5	-0.9	-0.1	0.2	0.1	0.1
Medication: Atorvastatin	1.0	1.2	3.1	0.9	1.8	1.5	1.1	-0.3	0.6	1.4	-0.5	1.2	1.4	0.8	0.7
Illnesses of father: High blood pressure	0.6	0.7	3.6	0.7	0.6	0.1	0.5	0.2	-0.9	-0.5	1.0	1.9	0.5	1.2	0.4
Alcohol drinker status: Never	0.6	0.7	2.9	-1.0	-1.4	-0.1	0.9	0.8	1.7	0.1	0.6	0.5	-0.4	-0.1	0.8
Ever smoked	0.5	0.9	4.1	1.6	1.5	0.4	-0.1	-0.4	0.4	2.0	1.0	-0.3	-0.0	-0.0	-0.8
Basal metabolic rate	0.2	0.9	3.5	-0.4	-0.8	1.9	-0.0	1.4	-1.0	0.4	0.8	-0.3	-0.4	0.6	1.6
Leg fat percentage (left)	0.2	0.7	2.5	0.2	-1.1	1.4	0.0	0.9	-0.2	0.2	-1.1	0.0	-0.3	0.5	1.6
Arm fat-free mass (left)	0.1	0.6	1.6	-1.0	-0.4	1.3	-0.6	0.7	-1.1	0.2	0.2	-0.7	-0.8	0.3	1.1
Number of operations (self-reported)	4.3	6.3	13.4	-2.7	-2.5	-2.6	-3.4	-2.5	-0.8	-1.2	-1.7	-3.7	-3.0	-2.7	-1.7
Average weekly beer plus cider intake	0.5	0.8	4.6	-0.2	0.0	0.8	-0.2	0.4	0.2	2.1	0.2	1.3	-0.3	-0.2	1.4
Irritability	0.4	0.8	2.4	-1.0	0.0	-1.3	-0.6	-0.2	-0.9	-1.5	-1.0	-0.9	-0.5	0.2	-0.9
Risk taking	0.8	1.1	5.0	1.0	0.6	-0.3	-1.7	-1.0	-2.2	-0.4	-0.5	-1.0	-1.1	-0.8	-0.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	4.7	0.8	0.5	-1.0	-0.8	-1.4	-2.2	-0.3	0.3	-0.8	-1.0	0.8	-1.5
Fractured/broken bones in last 5 years	1.1	1.4	6.2	1.6	2.5	0.2	1.3	0.2	-0.3	0.5	0.5	1.1	0.2	2.0	-0.2
Age started oral contraceptive pill	0.4	0.5	2.9	-1.1	-0.6	-0.0	-0.7	-0.0	-0.4	-0.6	-1.7	-0.1	0.5	-0.5	-0.3
Diastolic blood pressure, automated reading	0.5	1.5	5.0	-1.3	-2.2	1.3	-1.0	-0.4	1.3	1.7	-0.0	0.7	0.3	-1.6	0.7
Ever depressed for a whole week	0.4	0.4	1.6	0.6	-0.3	-0.1	0.3	-1.3	-1.2	-0.4	-0.3	-0.2	0.9	-0.0	-0.7
Unable to work because of sickness or disability	0.5	0.6	2.6	0.5	0.5	-0.6	0.7	1.4	-0.3	0.0	1.6	-0.9	-0.1	0.6	-0.6
Commuting to job workplace: Cycle	0.5	0.6	1.9	1.0	1.2	-0.5	0.0	-0.1	-0.7	-0.2	0.9	0.3	-0.2	1.4	-1.1
Myopia	0.5	0.7	1.9	0.8	-0.8	0.0	-0.2	-0.4	0.8	0.5	0.6	1.4	1.2	-1.3	-0.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	3.2	-0.9	-0.4	-0.7	-0.9	-0.0	0.6	-0.7	-0.2	-0.4	-0.7	-1.8	0.2
Cholesterol lowering medication	0.5	0.7	2.3	-0.7	1.1	0.2	0.7	-0.9	0.3	0.2	-1.5	1.2	1.0	0.1	0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.7	0.1	-0.1	1.4	0.6	-0.0	-0.6	0.1	-1.9	0.2	1.0	0.7	0.6
Pain experienced in last month	0.7	1.1	3.1	0.7	1.7	1.3	0.5	0.4	-0.3	0.8	-0.2	1.8	1.1	1.1	1.1
Supplements: Calcium	0.8	0.9	2.7	0.8	1.4	-0.4	0.5	-0.3	-0.6	-1.2	-0.3	-0.0	1.6	1.4	-1.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	0.5	-1.1	1.2	0.4	0.7	-0.5	0.7	-0.4	0.7	0.6	0.6	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	1.4	1.3	-0.4	-0.5	-1.1	-0.1	0.2	-1.1	-0.4	0.4	0.2	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.5	-0.4	-1.6	-0.6	0.5	0.5	0.6	-0.8	1.1	0.1	-1.2	1.0	0.3
Heart disease (siblings)	0.3	0.4	1.4	-0.1	0.5	-0.4	-0.3	-0.3	-0.6	-1.1	1.2	0.3	0.3	-0.6	0.7
Alcohol drinker status: Previous	0.2	0.2	0.8	0.5	-0.9	-0.5	-0.5	0.0	-0.1	0.2	0.3	-0.4	-0.4	-0.7	-0.4
Pack years of smoking	0.6	0.8	3.0	-1.5	0.2	-0.8	-0.6	-1.7	-0.2	-1.3	0.5	-1.0	0.0	-0.8	-0.0
Impedance of whole body	0.2	0.9	3.2	-0.5	-0.6	-1.2	0.0	-0.9	1.8	0.1	-1.0	1.1	0.9	-1.0	-1.0
Leg fat mass (left)	0.3	1.1	3.5	-0.3	-1.8	1.8	0.1	1.3	-0.3	0.2	-0.9	-0.1	-0.4	0.6	1.9
Arm predicted mass (left)	0.1	0.6	1.7	-1.0	-0.6	1.3	-0.6	0.7	-0.9	0.3	0.2	-0.7	-0.8	0.1	1.2