Hub : Genes

C9orf5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0471	0.0128	8.1e-07	0.017	0.025	0.031	0.029	0.027	2.1e-06	1.7e-08	2.2e-10	8.3e-10	3.1e-09
2	TCGA	Breast Invasive Carcinoma	0.0709	0.0306	1.7e-08	0.039	0.047	0.046	NA	0.046	1.8e-08	6.4e-10	8.0e-10	NA	8.7e-10
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0434	0.0216	1.8e-03	0.014	0.021	0.016	NA	0.021	9.0e-03	1.7e-03	5.1e-03	NA	1.7e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0376	0.0167	5.3e-04	0.025	0.030	0.046	NA	0.045	7.0e-04	2.1e-04	5.5e-06	NA	8.3e-06
5	TCGA	Brain Lower Grade Glioma	0.0824	0.0363	1.3e-05	0.013	0.046	0.032	NA	0.043	1.0e-02	6.0e-06	1.3e-04	NA	1.2e-05
6	TCGA	Lung Adenocarcinoma	0.0749	0.0268	5.1e-08	0.035	0.064	0.065	NA	0.051	5.9e-05	6.2e-08	4.9e-08	NA	1.3e-06
7	TCGA	Lung Squamous Cell Carcinoma	0.0574	0.0237	2.2e-05	0.069	0.058	0.059	NA	0.062	3.0e-08	3.8e-07	2.8e-07	NA	1.4e-07
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.0840	0.0410	6.7e-04	0.037	0.047	0.041	NA	0.041	1.6e-03	4.0e-04	8.5e-04	NA	8.6e-04
9	TCGA	Pancreatic Adenocarcinoma	0.1650	0.0680	7.7e-04	0.013	0.089	0.031	NA	0.029	8.7e-02	1.4e-04	1.8e-02	NA	2.1e-02
10	TCGA	Prostate Adenocarcinoma	0.1474	0.0488	5.3e-10	0.015	0.087	0.083	NA	0.062	8.4e-03	2.1e-09	4.7e-09	NA	4.9e-07
11	TCGA	Skin Cutaneous Melanoma	0.1470	0.0710	7.2e-03	0.018	0.016	0.012	NA	0.000	1.1e-01	1.2e-01	1.5e-01	NA	3.1e-01
12	TCGA	Stomach Adenocarcinoma	0.0630	0.0290	6.6e-04	0.055	0.030	0.020	NA	0.028	7.7e-05	3.0e-03	1.3e-02	NA	3.9e-03
13	TCGA	Thyroid Carcinoma	0.0820	0.0340	3.9e-06	0.042	0.074	0.072	NA	0.063	5.7e-05	1.1e-07	1.5e-07	NA	9.2e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.0	1.6	3.2	1.6	0.6	1.7	1.6	-1.8	0.7	1.2	1.2	1.6	0.7	0.8	1.3	1.0
Bipolar Disorder or Schizophrenia	0.3	0.8	4.6	0.4	-1.0	0.5	0.5	-2.1	-1.0	-0.4	0.5	-0.1	-1.2	-0.7	-0.7	-0.8
Depressed Affect (Nagel 2018)	0.5	1.1	4.9	-0.2	0.8	0.8	0.6	-2.2	-0.8	0.3	2.2	-0.7	-0.9	-0.1	-0.7	-0.2
Depression (Nagel 2018)	0.5	0.7	2.2	0.3	0.4	-0.2	-0.8	-0.1	-0.3	-0.1	-0.9	-1.1	-0.8	-1.5	-1.0	-1.5
Intelligence (Savage-Jansen 2018)	1.6	5.0	18.3	2.1	4.3	3.1	1.4	-1.9	2.3	3.2	2.0	1.5	-0.2	-0.1	2.1	1.0
Neuroticism (Nagel 2018)	0.2	0.6	2.5	0.0	1.0	0.6	0.2	-1.4	-0.3	0.2	1.6	-0.8	-0.6	-0.1	-0.6	-0.1
Schizophrenia (2018)	1.0	2.2	4.3	-0.8	-1.8	-0.8	-0.7	-1.3	-1.8	-1.5	-0.3	-1.4	-2.1	-1.6	-1.9	-1.9
Schizophrenia vs Biploar Disorder	2.6	3.4	7.0	-1.1	-0.9	-2.3	-2.6	2.1	-2.3	-2.3	-1.5	-1.1	-1.5	-2.1	-1.6	-1.7
Worry (Nagel 2018)	0.5	1.0	1.9	1.4	0.9	1.2	1.2	-0.9	1.2	0.9	0.6	1.0	0.7	0.7	1.0	0.8
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	-0.8	-0.8	-0.9	-0.6	0.7	-0.3	-0.7	-0.5	-0.3	-0.2	0.2	-0.3	-0.1
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.3	0.1	-0.3	0.0	-0.2	0.1	-0.2	-0.4	0.0	-0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	-1.2	-0.9	-1.3	-0.9	0.9	-0.5	-0.9	-0.7	-0.6	-0.4	-0.1	-0.6	-0.5
Crohns Disease (2017)	0.3	0.6	2.4	-1.1	-0.6	-0.0	0.7	-0.5	-0.2	-0.1	1.4	0.3	0.2	1.6	0.3	1.0
Irritable Bowel Disease (IBD)	0.5	1.1	3.9	-2.0	-1.8	-1.3	-0.6	0.8	-1.4	-1.4	-0.1	-0.5	-0.2	0.8	-0.5	0.2
Ulcerative Colitis (UC)	1.6	3.1	7.3	-2.4	-2.7	-2.1	-1.6	1.6	-2.3	-2.4	-1.4	-1.1	-0.9	-0.4	-1.2	-0.9
Major Depression (MDD)	3.0	3.6	5.5	-1.5	-1.7	-1.9	-2.3	0.8	-1.7	-2.2	-1.4	-2.1	-2.0	-2.0	-2.4	-2.2
Reaction Time	3.8	7.2	12.1	-1.4	-1.8	-3.3	-3.3	3.0	-3.4	-3.5	-2.4	-2.7	-1.3	-2.2	-3.1	-2.2
Verbal and Numeric Reasoning (VNR)	1.5	3.6	11.8	1.9	3.4	2.4	1.0	-1.2	1.8	2.6	2.1	1.5	0.3	0.6	2.0	1.4
Breast Cancer	0.4	0.9	2.7	-1.5	-0.0	-0.4	0.7	1.2	1.2	0.0	0.0	-0.5	1.4	1.6	-0.0	0.8
Ovarian Cancer	0.1	0.2	0.7	-0.4	-0.8	-0.2	0.0	-0.3	-0.6	-0.5	-0.1	-0.5	-0.2	0.0	-0.6	-0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.4	1.5	-0.4	0.1	-0.3	-0.5	-0.3	-0.6	-0.3	0.0	-0.8	-1.2	-0.9	-0.8	-0.9
Bipolar Disorder (2011)	1.8	1.7	4.2	2.1	0.9	1.8	1.5	-1.5	0.8	1.5	1.0	1.6	0.6	0.3	1.4	0.8
Body Mass Index (BMI) (2010)	4.0	5.4	15.1	-3.9	-2.3	-2.6	-1.5	0.3	-2.0	-2.5	-0.3	-3.5	-1.5	-0.8	-3.4	-2.3
Coronary Artery Disease (CAD)	0.5	0.6	2.8	0.9	0.1	1.1	0.3	-1.7	0.3	0.7	-0.2	0.1	-0.5	-1.1	-0.0	-0.9
Crohns Disease (2012)	0.4	0.6	1.5	-0.3	-0.1	0.6	1.1	-0.7	0.9	0.7	1.0	0.8	0.4	1.2	0.8	0.9
Mean Putamen Volume	0.8	1.0	3.1	-0.4	-0.4	-0.5	-1.2	0.3	-0.6	-1.0	-0.7	-0.5	-1.7	-1.8	-1.0	-1.2
Fasting Glucose	1.3	1.5	4.5	2.1	1.6	1.5	0.8	-0.7	-0.3	1.5	1.2	0.4	1.7	0.7	0.7	1.0
HbA1C	1.6	1.8	4.4	-0.4	-0.8	-1.8	-1.9	1.1	-0.1	-1.3	-2.1	-0.2	-1.2	-1.8	-0.8	-1.6
HDL Cholesterol	0.8	1.4	3.8	0.5	0.5	0.7	1.9	-0.7	0.7	1.3	1.0	0.8	1.0	1.9	1.4	1.6
LDL Cholesterol	3.9	6.2	9.7	-2.2	-2.4	-3.0	-2.6	0.8	-3.1	-3.0	-1.2	-2.4	-2.4	-2.3	-3.0	-2.6
Lupus	0.1	0.2	1.6	0.0	0.3	-0.2	0.1	-0.3	-0.2	-0.3	1.3	0.1	-0.0	0.7	0.0	0.6
Neuroticism (2016)	1.0	1.4	4.8	-1.2	-1.0	0.0	0.3	-2.2	-1.0	-0.5	1.1	-1.6	-1.6	-0.3	-1.4	-1.1
Primary Biliary Cirrhosis	1.0	1.5	6.2	-2.5	-1.3	-1.0	-0.8	-0.0	-1.9	-1.0	1.0	-1.3	-1.1	0.2	-1.1	-0.4
Rheumatoid Arthritis	1.6	2.3	7.1	0.2	0.4	0.5	1.5	-0.2	0.7	0.8	1.8	1.7	1.8	2.7	1.8	2.4
Schizophrenia (2014)	0.3	0.6	1.5	0.2	-0.9	-0.0	0.1	-1.2	-1.1	-0.7	-0.0	-0.4	-1.0	-0.9	-1.0	-0.9
Triglycerides	3.1	5.1	8.9	-2.5	-1.9	-2.5	-3.0	1.5	-2.2	-2.8	-1.8	-1.9	-2.0	-2.2	-2.4	-2.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.9	0.2	1.3	0.9	-0.1	-1.0	1.1	0.7	1.4	1.0	-0.6	-0.2	0.5	0.3
Ulcerative Colitis	1.4	2.1	3.9	-2.0	-1.9	-1.7	-1.6	1.3	-1.8	-2.0	-1.0	-0.9	-1.1	-0.5	-1.1	-0.8
Blood Eosinophil Count	0.1	1.0	3.5	-1.4	-0.8	-1.4	-0.7	1.9	-0.5	-1.0	-1.4	-0.8	0.5	0.1	-0.5	-0.2
Blood Platelet Count	0.3	3.5	7.3	2.7	2.3	2.6	1.5	-2.3	1.3	2.1	2.1	1.8	1.0	0.7	1.6	1.1
Blood Red Count	0.1	1.4	7.2	0.7	1.2	-1.1	-1.3	2.7	-0.5	-0.8	-1.4	-0.3	-0.3	-1.6	-0.3	-0.7
Blood White Count	0.2	1.8	5.7	1.3	0.8	1.2	1.8	0.3	0.8	0.9	0.8	0.8	2.4	1.8	1.1	1.8
Heel T-Score	0.3	2.0	5.6	1.5	-1.3	0.6	2.0	-1.2	0.7	0.3	-0.3	2.4	0.6	1.6	2.1	1.6
BMI	1.4	8.0	25.0	-5.0	-3.1	-3.5	-1.4	2.6	-2.0	-3.2	-1.7	-3.6	-0.4	-0.6	-3.5	-2.2
Height	1.4	27.1	49.0	-7.0	-4.7	-6.7	-6.0	4.6	-3.5	-5.5	-4.2	-5.9	-3.7	-3.5	-5.8	-5.1
Waist Hip Ratio (WHR)	5.9	26.5	38.3	-5.6	-5.0	-5.0	-6.1	1.6	-4.7	-5.1	-3.4	-5.3	-5.8	-5.5	-5.8	-6.2
Systolic Blood Pressure	0.2	1.2	5.7	1.9	0.2	0.0	-0.8	1.6	0.2	0.3	-2.4	0.9	0.3	-1.2	0.9	-0.5
Smoking Status	1.4	3.3	10.7	-1.9	-2.5	-1.6	-1.7	0.3	-3.3	-2.6	-0.1	-1.1	-1.5	-1.2	-1.9	-1.2
Allergy or Eczema	0.3	0.9	5.4	-2.3	-1.8	-0.8	0.1	0.1	0.2	-0.4	-0.8	-0.6	-0.2	0.4	-0.5	-0.5
Cardiovascular Disease	0.6	2.0	6.4	-0.6	-0.8	-1.7	-1.5	2.5	-0.5	-1.5	-2.3	-0.8	-0.2	-1.3	-1.0	-1.3
Hypothyroidism (self reported)	0.1	0.3	1.4	-0.5	-1.1	0.1	0.3	-1.2	0.1	-0.1	-0.1	-0.5	-0.5	-0.2	-0.5	-0.6
Respiratory disease	0.4	0.8	2.5	-0.3	-0.4	-0.3	0.9	1.0	1.5	0.4	-1.5	0.2	1.6	0.9	0.5	0.2
Type 2 Diabetes (T2D) (2018)	0.8	1.5	5.3	-1.1	-2.3	-1.2	-0.4	0.0	-1.0	-1.7	-0.8	-1.4	-0.6	-0.6	-1.6	-1.3
Lung FEV1/FVC ratio	0.7	3.7	9.7	-2.8	-2.1	-0.2	-0.6	-3.1	-1.6	-1.1	1.3	-1.7	-2.7	-1.2	-2.2	-1.9
Lung FVC	0.5	2.4	8.5	1.6	1.1	-0.1	0.3	2.9	-0.1	-0.1	-0.2	1.7	1.9	1.6	2.0	2.5
Neuroticism	0.3	0.8	4.6	-0.5	0.3	0.7	0.8	-2.1	-0.2	0.3	1.3	-0.8	-1.0	-0.4	-0.8	-0.6
Chronotype (morning person)	3.4	7.9	11.6	-3.2	-3.0	-3.2	-3.0	1.4	-2.9	-3.4	-1.6	-2.8	-2.6	-2.3	-3.4	-2.7
Hair Pigment	0.4	10.4	20.1	-4.5	-2.8	-2.8	-2.8	-0.6	-3.6	-3.0	-0.5	-4.3	-4.1	-2.5	-3.9	-3.4
Tanning	0.0	0.1	0.4	-0.5	-0.2	-0.6	-0.3	0.5	0.5	-0.4	-0.4	0.0	0.3	0.0	-0.2	-0.2
Hand grip strength (left)	0.2	0.5	2.8	-1.2	-0.0	-0.2	-1.0	1.7	0.1	-0.6	-0.8	-0.1	0.1	-0.4	-0.3	-0.3
Number of treatments/medications taken	0.8	1.4	4.0	-1.0	-1.5	-1.4	-0.6	0.6	0.5	-0.8	-2.0	-1.3	-0.1	-0.8	-1.4	-1.7
Average weekly spirits intake	1.4	1.8	7.1	0.3	1.2	0.1	0.4	2.1	0.6	0.1	0.4	1.3	2.7	1.8	1.1	1.9
Sensitivity / hurt feelings	0.3	0.4	1.6	-0.7	-0.1	-0.1	-0.3	-1.3	-0.4	-0.4	1.0	-0.7	-0.8	-0.3	-0.9	-0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	-0.6	0.5	-0.5	-0.9	-0.2	-0.7	-0.5	-0.2	-1.3	-0.9	-1.1	-1.4	-1.3
Hearing difficulty/problems: Yes	2.0	3.0	7.5	1.8	2.7	2.3	1.3	-1.7	1.9	2.4	1.5	1.5	-0.1	0.4	1.7	1.2
Relative age of first facial hair	3.7	7.7	10.6	-1.6	-3.0	-3.0	-3.1	1.2	-2.7	-3.0	-2.6	-2.6	-3.0	-2.9	-3.1	-3.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.2	-1.0	-1.5	-1.5	-1.2	1.8	-0.5	-1.3	-1.2	0.2	0.1	0.1	-0.2	0.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	0.9	0.4	0.2	1.0	-0.2	1.2	0.5	-0.5	0.4	0.7	0.3	0.5	0.2
Ever had hysterectomy (womb removed)	3.7	4.2	6.5	-2.6	-2.2	-2.3	-1.9	1.8	-1.9	-2.4	-2.0	-2.4	-1.3	-1.3	-2.3	-2.0
Systolic blood pressure, automated reading	0.8	2.4	11.3	-0.2	-1.8	-1.7	-1.4	2.1	-0.8	-1.3	-3.4	-0.7	-0.3	-1.3	-0.7	-1.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.5	1.3	0.7	0.6	0.6	0.7	1.6	0.6	-1.0	0.5	1.4	0.2	0.4	0.1
Angina	3.1	4.1	7.2	-1.9	-1.7	-2.2	-2.7	1.9	-2.4	-2.3	-1.4	-2.2	-1.3	-1.6	-2.3	-1.7
Medication for hormone replacement therapy	1.0	1.1	2.6	-0.9	-1.3	-1.4	-0.1	1.4	-0.5	-1.2	-1.3	-1.6	0.8	0.3	-1.2	-0.5
Vitamin and mineral supplements	0.2	0.2	0.6	0.5	0.5	0.6	0.6	-0.8	0.1	0.8	0.6	-0.2	0.1	0.5	0.3	0.3
Supplements: Zinc	0.2	0.2	0.6	-0.6	-0.2	-0.2	-0.8	0.4	-0.2	-0.4	-0.2	-0.7	-0.6	-0.5	-0.6	-0.4
Medication: Co-codamol	1.6	1.8	8.0	-1.1	0.0	-1.8	-2.0	2.8	-0.7	-1.5	-1.3	-0.6	-0.5	-1.1	-1.0	-0.6
Medication: Metformin	0.5	0.8	3.3	0.3	-0.4	-0.5	0.5	1.7	0.9	-0.3	-1.1	-0.2	1.8	0.9	-0.1	0.5
Diabetes (father)	0.8	1.0	2.6	-1.1	-1.1	-0.3	-0.7	-1.2	-0.8	-0.3	-0.4	-0.5	-1.6	-1.5	-0.7	-1.6
Diabetes (mother)	2.4	3.0	7.3	-1.9	-1.8	-1.9	-1.6	0.3	-1.6	-1.7	-1.0	-2.7	-1.1	-1.2	-2.4	-2.0
Severe depression (siblings)	1.3	1.4	2.6	1.3	0.7	1.1	1.2	-0.9	1.6	1.5	1.0	1.1	1.2	1.3	1.1	1.2
Pack years adult smoking proportion	2.5	3.8	7.4	-1.6	-1.7	-2.1	-1.5	1.5	-2.3	-2.2	-2.0	-2.7	-0.6	-1.6	-2.6	-2.1
Impedance of leg (right)	1.0	4.8	18.6	4.3	3.4	2.8	-1.0	-1.9	-0.1	2.2	0.3	1.3	-1.6	-3.0	1.3	-0.7
Leg fat-free mass (left)	2.2	11.9	37.5	-6.1	-3.7	-4.8	-2.3	3.5	-1.7	-4.2	-1.9	-4.0	-0.5	-0.0	-4.2	-2.2
Trunk fat percentage	2.5	9.9	19.4	-3.7	-2.5	-3.0	-3.0	1.5	-2.9	-3.4	-2.0	-4.0	-2.4	-3.1	-4.4	-3.7
Hand grip strength (right)	0.1	0.3	1.0	-0.6	0.4	0.4	-0.5	0.7	0.2	0.1	-1.0	-0.3	-0.2	-0.8	-0.2	-0.6
Townsend deprivation index at recruitment	1.0	1.4	3.8	-1.7	-1.7	-1.5	-0.9	0.7	-1.9	-1.5	-0.2	-1.0	-0.5	-0.1	-1.1	-0.7
Current tobacco smoking	1.9	3.2	12.7	-1.7	-2.8	-1.5	-1.6	0.9	-3.6	-2.4	-0.5	-1.3	-0.8	-0.8	-1.6	-1.1
Average weekly fortified wine intake	0.8	0.9	4.7	-0.5	-1.2	-1.1	-0.4	1.6	-0.0	-0.6	-2.2	-0.7	0.1	-0.3	-0.3	-0.5
Maternal smoking around birth	5.1	7.4	11.3	-2.6	-2.9	-2.8	-3.4	1.5	-2.9	-3.1	-2.1	-2.2	-2.4	-2.8	-3.0	-3.0
Fed-up feelings	0.7	1.2	4.2	-0.6	0.9	0.6	0.4	-2.0	-0.7	0.1	2.0	-1.4	-0.9	-0.3	-1.4	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.4	-0.3	-0.4	-0.7	-1.1	-0.1	-0.9	-0.8	-1.1	-0.9	-1.2	-1.9	-1.4	-1.8
Relative age voice broke	0.5	0.8	3.4	0.6	-1.5	0.1	0.0	-1.8	-1.0	-0.5	-0.1	0.3	-1.6	-0.7	-0.2	-0.8
Taking other prescription medications	1.2	1.8	3.8	-1.8	-1.4	-1.5	-0.9	0.4	-0.4	-0.9	-1.4	-1.9	-0.6	-1.0	-1.9	-1.8
Age when periods started (menarche)	11.5	27.6	41.5	-5.7	-4.6	-6.0	-6.4	3.5	-5.0	-5.8	-4.3	-4.9	-4.8	-5.2	-5.7	-5.7
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.5	-0.3	-0.7	-0.9	-0.4	1.0	-0.4	-0.9	-1.2	-0.8	0.1	-0.4	-0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.2	-1.0	-0.9	-0.4	0.5	-0.1	1.1	-0.0	-0.0	0.0	0.5	1.1	0.1	0.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	6.1	-0.2	-0.4	1.1	1.0	-2.5	0.7	1.0	0.3	0.2	-0.4	-0.2	0.2	-0.6
Qualifications: CSEs or equivalent	0.2	0.3	1.3	0.5	0.4	-0.4	-0.6	1.1	-0.4	-0.3	-0.9	0.0	0.4	-0.8	-0.2	-0.4
Serious illness, injury or assault to yourself	2.0	2.4	4.0	-2.0	-1.8	-2.0	-1.7	1.1	-1.4	-2.0	-0.8	-1.9	-0.9	-0.6	-2.0	-1.1
High blood pressure	0.5	1.5	6.5	-0.4	-1.1	-1.2	-1.2	1.8	0.0	-1.0	-2.6	-0.5	-0.2	-1.3	-0.6	-1.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.5	-1.6	-1.1	-0.5	0.2	0.5	0.6	-0.2	-0.9	0.0	0.3	0.5	0.1	-0.1
Multivitamins +/- minerals	0.2	0.3	1.2	0.3	0.0	-0.3	-0.3	1.1	0.4	-0.3	-0.8	0.9	0.6	-0.3	0.2	0.2
Stomach or abdominal pain in last month	0.7	0.9	1.7	-0.6	-0.4	-1.1	-0.9	0.6	-1.0	-1.0	-0.8	-1.1	-0.7	-1.0	-1.3	-1.1
Supplements: Glucosamine	0.4	0.5	1.7	0.2	0.4	0.3	0.8	0.6	0.9	0.6	0.1	0.6	1.3	0.8	0.6	0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.3	0.5	0.3	-0.0	-0.0	0.3	0.3	-0.1	-0.3	0.1	-0.2	-0.2	-0.2
Medication: Atenolol	0.5	0.6	1.6	-0.8	-0.6	-0.5	-0.6	-0.1	-0.2	-0.4	-0.8	-0.9	-1.3	-1.1	-0.8	-1.0
Medication: Levothyroxine sodium	0.2	0.3	1.4	-0.7	-1.2	-0.5	-0.4	-0.1	-0.2	-0.7	-0.2	-0.4	-0.1	0.0	-0.6	-0.3
Sitting height	0.1	0.5	2.8	-1.7	-0.4	-0.8	-0.2	0.5	0.5	-0.3	0.9	-0.6	0.2	1.1	-0.3	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	-0.0	0.6	0.1	-0.1	0.4	0.0	0.2	0.2	0.5	0.5	0.2	0.4	0.7
High blood pressure (mother)	0.2	0.3	1.8	0.1	0.7	-0.4	-0.7	1.3	0.6	-0.0	-0.7	-0.1	0.3	-0.2	0.1	-0.0
Body mass index (BMI)	1.6	6.8	17.9	-4.2	-2.7	-3.2	-1.5	1.8	-1.3	-3.1	-1.7	-3.4	-1.0	-1.1	-3.7	-2.4
Impedance of leg (left)	0.9	4.6	17.0	4.1	2.5	2.7	-0.8	-2.3	-0.2	2.2	0.1	2.0	-1.8	-2.8	1.7	-0.6
Leg predicted mass (left)	2.1	11.2	36.0	-6.0	-3.6	-4.7	-2.2	3.6	-1.6	-4.1	-1.8	-3.8	-0.3	0.1	-4.0	-2.0
Trunk fat mass	2.9	12.3	23.7	-4.7	-3.0	-3.8	-3.2	2.1	-2.7	-3.9	-2.3	-4.5	-2.2	-2.7	-4.9	-3.8
Waist circumference	4.5	16.6	34.5	-5.9	-4.0	-4.8	-3.6	2.5	-2.6	-4.5	-2.9	-5.0	-2.9	-2.8	-5.4	-4.2
Number of incorrect matches in round	0.4	0.7	2.4	0.3	-0.8	-0.0	1.1	0.5	0.8	-0.4	0.0	0.3	1.6	1.5	0.2	0.8
Past tobacco smoking	2.3	4.3	8.6	1.9	1.2	2.5	2.7	-1.9	2.1	2.9	1.1	1.4	1.6	2.2	2.4	1.9
Alcohol usually taken with meals	5.4	8.7	14.4	3.8	3.7	3.6	2.6	-1.2	2.9	3.4	2.5	3.2	2.2	1.8	3.3	2.9
Nervous feelings	0.3	0.5	2.0	1.2	0.1	0.1	0.6	0.7	0.7	0.3	-0.9	0.5	1.4	0.5	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	0.4	0.6	0.2	0.3	-0.3	-0.4	-0.1	0.4	-0.5	0.2	-0.0	-0.5	-0.1
Hearing difficulty/problems with background noise	0.5	0.7	3.4	0.9	1.8	1.2	-0.1	-0.7	0.7	1.3	0.7	-0.2	-0.5	-0.7	0.1	-0.0
Hair/balding pattern: Pattern 2	0.3	0.3	1.3	-0.8	0.0	0.4	-0.1	0.2	0.0	-0.1	1.1	0.9	-0.6	0.3	0.7	0.6
Had menopause	0.5	0.7	2.0	0.5	0.1	0.9	1.4	-0.8	1.4	0.9	0.3	0.5	0.1	0.8	0.8	0.7
Had other major operations	0.4	0.4	0.7	0.0	0.3	0.8	0.8	-0.6	0.8	0.6	0.7	0.8	0.6	0.7	0.7	0.6
Forced vital capacity (FVC)	0.7	2.8	17.9	-0.7	-0.7	-2.3	-2.0	4.2	-0.7	-1.9	-1.8	0.4	0.4	-0.0	0.0	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-1.0	-0.9	-0.1	0.6	-0.8	0.9	0.0	-0.0	0.2	-0.1	0.8	0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.9	-0.9	-0.4	-0.3	-1.0	-0.7	-1.3	-0.9	0.3	-1.3	-1.7	-1.2	-1.3	-1.2
Qualifications: None of the above	7.3	15.7	23.2	-2.8	-4.3	-4.4	-4.8	1.9	-4.3	-4.4	-3.9	-3.3	-3.8	-4.2	-4.0	-4.6
Financial difficulties in last 2 years	1.3	1.7	3.1	-1.7	-0.8	-1.2	-1.5	0.0	-1.8	-1.5	-0.3	-1.1	-1.3	-1.4	-1.7	-1.6
Mouth/teeth dental problems	2.4	3.7	8.7	2.9	2.2	2.4	1.7	-1.7	1.5	2.2	1.5	2.2	1.1	0.8	2.2	1.5
Heart attack	0.4	0.4	2.3	-1.2	-0.3	0.0	0.1	-0.7	-0.6	-0.1	1.5	-0.7	-0.2	0.5	-0.6	0.1
Allergy	0.4	0.8	4.5	2.1	1.7	0.9	0.1	-0.3	0.0	0.6	1.1	0.5	0.0	-0.2	0.5	0.6
Pain all over the body in last month	0.6	0.7	2.0	-0.2	0.0	-0.8	-1.4	0.7	-0.9	-1.0	-0.5	0.2	-0.9	-1.4	-0.6	-0.7
Diabetes (self-reported)	0.4	0.6	2.3	-0.0	-0.5	-0.6	-0.2	1.1	0.4	-0.5	-1.5	-1.0	0.7	-0.5	-0.9	-0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	3.3	-0.7	0.2	0.4	0.5	0.1	1.8	0.7	-0.6	0.3	0.5	0.6	0.6	0.2
Medication: Ramipril	1.0	1.3	5.2	0.6	-0.0	-0.6	-1.5	0.2	-1.1	-0.7	-1.2	-0.7	-1.4	-2.3	-0.9	-1.7
Medication: Simvastatin	0.5	0.7	1.6	-0.8	-1.2	-1.2	-0.3	0.2	0.5	-0.5	-1.2	-1.0	-0.1	-0.1	-1.0	-1.0
Fluid intelligence score	3.9	8.2	23.5	3.3	4.8	3.3	2.1	-0.8	3.2	3.5	2.2	2.9	1.5	1.2	3.2	2.5
Illnesses of siblings	0.3	0.4	0.9	-0.3	0.8	-0.4	-0.0	0.8	0.9	-0.0	0.4	0.7	0.8	0.9	0.5	1.0
Neuroticism score	0.2	0.5	2.7	0.3	0.7	0.7	0.8	-1.6	0.3	0.4	1.0	-0.3	-0.2	-0.1	-0.4	-0.3
Weight	2.7	13.1	32.9	-5.7	-3.5	-4.7	-3.0	3.1	-2.1	-4.3	-2.4	-4.4	-1.5	-1.5	-4.8	-3.2
Impedance of arm (right)	0.4	1.9	8.1	1.2	0.2	0.2	-2.2	-0.4	-2.9	-0.3	0.0	-0.3	-1.7	-2.3	-0.4	-1.2
Arm fat percentage (right)	2.5	10.0	19.0	-4.1	-3.1	-3.4	-2.6	1.9	-2.8	-3.7	-2.2	-4.0	-1.8	-2.3	-4.4	-3.4
Trunk fat-free mass	1.2	6.8	23.2	-4.8	-2.6	-4.0	-1.7	3.1	-0.2	-3.0	-1.8	-2.8	-0.3	0.3	-2.9	-1.4
Hip circumference	0.8	3.6	11.7	-3.4	-1.5	-2.5	-1.2	2.0	-0.4	-2.3	-1.4	-2.3	-0.4	-0.6	-2.6	-1.6
Time employed in main current job	0.5	0.5	1.8	-0.2	-1.2	-0.6	0.3	1.2	-0.2	-0.6	-0.4	-0.0	0.9	1.3	0.3	0.8
Alcohol intake versus 10 years previously	0.3	0.4	1.1	-0.0	0.7	0.5	-0.1	-1.0	-0.4	-0.0	0.7	-0.3	-0.9	-0.9	-0.6	-0.7
Father’s age at death	1.5	2.0	4.5	2.1	1.7	1.4	1.4	0.2	1.8	1.6	-0.1	1.4	1.9	0.8	1.5	1.1
Worrier / anxious feelings	1.4	2.7	6.0	1.6	1.9	2.5	1.7	-2.3	2.1	2.1	1.1	1.3	0.4	0.2	1.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	-0.7	-0.3	0.1	0.1	-0.9	-0.7	-0.5	0.7	-1.2	-0.3	-0.2	-1.4	-0.7
Falls in the last year	0.6	0.9	2.6	-0.4	-1.3	-1.1	-0.8	1.6	-1.5	-0.8	-0.6	0.3	0.5	0.7	0.5	0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.4	-0.2	-0.8	-0.3	0.4	0.8	-0.1	-0.7	-0.5	0.2	0.1	-0.5	-0.1
Number of live births	0.5	0.7	3.4	-0.2	0.3	-0.7	0.1	1.9	0.7	-0.2	-1.4	0.4	1.5	0.1	0.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	8.6	-1.0	-0.8	-1.7	-1.6	2.9	-0.8	-1.8	-0.8	0.3	0.1	0.0	-0.2	0.1
Pulse rate	0.4	0.7	2.5	-1.3	-1.6	-1.2	-0.1	0.3	-0.6	-1.4	0.1	-0.1	0.3	1.0	-0.5	0.2
Happiness	0.2	0.2	0.6	-0.1	0.8	0.1	-0.3	-0.2	0.4	-0.2	0.3	-0.6	-0.2	-0.6	-0.7	-0.6
Noisy workplace	0.0	0.1	0.2	0.1	-0.4	0.4	0.2	-0.4	0.4	-0.1	-0.1	0.1	0.1	-0.1	-0.2	-0.1
Qualifications: A levels/AS levels or equivalent	1.7	3.8	6.4	1.8	2.5	2.3	1.6	-0.8	1.8	2.4	1.8	2.1	1.6	1.4	2.5	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.0	1.6	1.7	1.3	0.9	-0.2	2.0	1.4	-0.1	1.5	0.8	0.0	1.4	0.7
Mouth/teeth dental problems: Dentures	3.2	5.4	10.5	-2.5	-2.2	-3.2	-2.5	2.8	-2.1	-2.9	-2.0	-2.5	-0.9	-1.1	-2.5	-1.8
Asthma	0.2	0.4	1.5	-0.2	-0.5	0.4	0.9	-0.1	1.2	0.8	-0.7	0.2	0.8	0.7	0.4	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.5	-1.1	-1.0	-1.8	-1.2	1.1	-1.3	-1.9	-0.6	-0.6	-0.7	-0.6	-1.3	-0.6
Medication: Cholesterol lowering	0.3	0.4	1.5	-0.1	-0.7	0.0	-0.1	-1.2	0.1	0.3	-0.1	-0.9	-0.6	-0.5	-0.8	-1.1
Depression (self-reported)	0.6	0.7	2.2	0.0	1.3	0.9	0.3	-1.5	-0.1	0.6	1.3	-0.7	-0.6	-0.5	-0.4	-0.6
Medication: Lansoprazole	0.1	0.1	0.2	-0.4	0.3	-0.2	-0.2	0.4	0.3	0.1	-0.1	-0.4	0.1	-0.2	-0.5	-0.1
Prospective memory result	1.0	1.2	2.2	-1.3	-1.0	-1.1	-1.4	0.3	-1.3	-1.5	-0.0	-0.8	-1.5	-0.9	-1.0	-0.9
Lung cancer (father)	1.1	1.2	4.0	-0.4	-0.5	-0.6	-1.1	-1.2	-1.4	-0.8	0.6	-0.8	-2.0	-1.5	-1.2	-1.3
Illnesses of mother	0.4	0.5	1.0	0.1	0.8	0.4	0.9	-0.0	0.7	0.5	0.8	0.9	0.7	1.0	0.8	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	5.6	-0.7	-0.5	-1.5	-1.7	2.4	-0.4	-1.3	-0.9	0.5	-0.2	-0.2	-0.0	0.1
Pulse wave Arterial Stiffness index	0.8	0.9	3.3	-1.0	0.5	0.1	-0.6	-1.0	-0.8	-0.3	1.8	-1.1	-1.5	-0.4	-1.0	-0.5
Impedance of arm (left)	0.4	1.8	5.1	2.0	1.2	1.0	-1.6	-0.9	-2.3	0.3	0.7	0.1	-1.5	-2.1	0.1	-0.8
Arm fat mass (right)	2.7	11.2	25.1	-5.0	-3.3	-3.9	-2.7	2.4	-2.2	-3.9	-2.3	-4.3	-1.6	-1.9	-4.6	-3.3
Trunk predicted mass	1.2	6.9	22.8	-4.8	-2.5	-4.0	-1.7	3.2	-0.2	-3.0	-1.9	-2.8	-0.2	0.3	-2.9	-1.4
Standing height	0.7	7.3	16.7	-4.1	-2.2	-3.8	-3.5	3.0	-1.9	-3.0	-1.6	-2.6	-1.5	-1.2	-2.8	-2.1
Length of working week for main job	0.8	0.9	4.1	0.1	-1.0	-1.2	-0.9	1.6	-0.5	-1.0	-2.0	-0.3	0.0	-0.6	-0.4	-0.5
Exposure to tobacco smoke at home	4.9	5.5	12.1	1.1	0.8	2.5	3.5	-3.1	2.2	2.5	2.2	1.9	2.0	2.8	2.2	2.3
Breastfed as a baby	3.2	4.0	6.8	2.5	1.7	1.8	1.9	-0.7	1.4	2.0	1.4	2.4	1.9	2.2	2.6	2.5
Tense / ‘highly strung’	0.2	0.3	0.7	0.9	0.2	-0.4	0.2	0.5	-0.7	-0.4	-0.8	-0.8	0.6	-0.2	-0.5	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.5	0.0	0.3	0.2	-1.2	-1.3	-1.5	-0.7	0.5	-1.6	-1.9	-1.9	-1.4	-1.6
Hair/balding pattern: Pattern 4	0.1	0.4	1.4	0.2	0.9	0.1	0.2	0.1	0.4	0.5	-0.3	-1.2	1.1	0.0	-0.6	-0.4
Birth weight of first child	0.2	0.4	1.3	-1.1	0.2	-0.8	-0.6	1.2	0.8	0.1	-0.7	-0.8	-0.1	-0.1	-0.3	-0.5
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.5	-0.5	0.0	-0.1	0.4	-0.0	-0.6	0.6	-0.1	0.5	0.6	-0.4	0.2
Pulse wave reflection index	0.4	0.5	1.7	-0.0	0.9	0.7	-0.0	-0.7	-0.2	0.4	0.7	-1.3	-0.7	-0.7	-0.8	-0.8
Ever highly irritable/argumentative for 2 days	5.7	6.8	13.5	-2.1	-1.3	-2.0	-2.7	0.4	-2.0	-2.4	-1.7	-3.7	-3.1	-3.3	-3.5	-3.5
Loud music exposure frequency	5.6	6.2	11.0	1.9	2.6	3.3	3.1	-2.2	2.2	3.0	2.7	2.1	1.9	2.0	2.4	2.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.0	-0.1	1.4	0.9	1.0	0.2	0.1	0.9	1.7	0.2	1.2	1.6	0.9	1.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.6	0.0	-0.1	1.1	0.9	-1.2	0.6	0.7	0.6	0.4	-0.2	0.2	0.4	0.4
Blood clot in the leg (DVT)	2.2	2.8	7.0	-2.6	-1.9	-1.7	-1.0	-0.0	-2.1	-2.0	-0.3	-1.9	-1.3	-0.9	-2.2	-1.6
Medication: Paracetamol	1.6	2.6	4.8	-2.0	-1.9	-1.9	-1.5	1.1	-2.2	-2.1	-0.8	-1.8	-0.9	-0.9	-1.8	-1.3
Headache pain in last month	0.3	0.4	1.7	-1.1	-0.4	-0.1	0.6	-0.5	-0.3	-0.0	0.5	-1.3	0.5	0.9	-0.8	0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.1	-0.3	0.6	-0.0	-0.1	0.6	-0.3	-0.3	0.9	0.5	0.2	0.7	0.5	1.0
Glaucoma (self-reported)	0.7	0.8	2.2	-0.8	-0.4	0.4	1.3	-1.1	0.2	0.1	1.4	-1.5	0.5	1.3	-0.8	0.3
Gout (self-reported)	0.8	1.1	3.8	0.2	0.1	-1.3	-1.1	1.8	-0.4	-0.8	-2.0	-0.7	0.3	-1.0	-0.8	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.6	-0.9	-1.3	-0.5	-0.4	-0.4	-0.4	-0.7	-0.5	-0.8	-0.6	-0.3	-0.9	-0.7
Medication: Amlodipine	0.7	1.0	2.3	0.7	1.3	1.2	1.3	-0.4	1.5	1.3	0.4	0.6	0.9	0.9	1.1	0.9
Medication: Ventolin 100micrograms inhaler	1.2	1.5	5.8	-2.4	-2.0	-1.4	-0.6	0.2	-0.4	-1.0	-0.5	-1.5	-0.4	0.0	-1.6	-1.2
Birth weight	0.4	1.0	6.6	-1.2	0.7	-1.1	-1.3	2.6	0.0	-0.7	-0.2	-0.5	0.2	0.0	-0.2	0.1
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.0	-0.2	-0.9	-0.4	-1.0	-0.4	-0.9	-0.5	-1.2	-1.4	-1.3	-2.0	-1.6	-2.0
High blood pressure (siblings)	1.3	1.8	4.4	-1.8	-2.1	-0.8	-0.9	-0.5	-1.0	-0.8	-1.1	-1.4	-1.8	-1.3	-1.3	-1.8
Forced vital capacity (FVC), Best measure	0.7	2.6	15.0	-0.6	-0.5	-2.4	-2.4	3.9	-0.4	-1.8	-1.8	0.6	-0.1	-0.3	0.0	0.1
Body fat percentage	2.3	9.0	18.7	-3.5	-2.5	-2.8	-2.8	1.1	-2.7	-3.2	-1.9	-3.9	-2.4	-3.0	-4.3	-3.6
Leg fat percentage (right)	1.2	4.5	11.3	-2.1	-1.0	-1.6	-1.9	0.6	-1.4	-2.0	-1.2	-3.0	-1.8	-2.6	-3.4	-2.9
Arm fat-free mass (right)	1.3	6.8	22.0	-4.7	-2.5	-3.8	-1.6	3.0	-0.2	-3.0	-1.9	-3.0	-0.3	0.1	-3.1	-1.6
Exposure to tobacco smoke outside home	1.0	1.3	2.3	-0.9	-1.2	-1.2	-1.2	1.0	-1.4	-1.5	-1.3	-0.8	-0.6	-1.1	-1.2	-1.1
Comparative body size at age 10	0.5	1.4	4.6	-0.6	1.3	1.1	1.8	-0.8	2.1	1.4	1.1	-0.3	1.0	1.5	0.2	0.8
Number of full brothers	3.5	4.5	10.8	-1.6	-1.4	-2.3	-2.6	1.5	-3.3	-2.8	0.1	-1.9	-1.9	-1.8	-2.5	-1.6
Worry too long after embarrassment	0.3	0.5	2.3	-0.2	1.5	0.7	0.0	-0.8	0.6	0.5	1.2	-0.5	-0.3	-0.0	-0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.8	0.8	1.1	1.0	0.9	-0.8	0.2	0.6	1.7	0.8	0.9	1.1	0.9	1.2
Wheeze or whistling in the chest in last year	2.8	5.0	11.4	-3.4	-3.2	-2.1	-1.6	-0.4	-2.2	-2.0	-0.9	-2.6	-2.2	-1.4	-2.8	-2.4
Number of children fathered	1.6	1.8	3.9	-0.0	-1.0	-1.3	-1.8	1.4	-1.4	-1.4	-2.0	-0.9	-1.1	-1.6	-0.9	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.6	0.0	0.6	-0.3	-0.3	-1.0	-0.9	-0.1	1.1	-1.2	-1.3	-0.7	-0.9	-0.9
Age at first live birth	5.9	10.5	16.6	2.3	3.4	3.6	3.5	-2.3	2.9	3.5	4.1	3.4	1.8	3.2	3.7	3.7
Pulse wave peak to peak time	0.8	1.0	3.0	0.8	-0.6	-0.2	0.6	1.2	0.8	0.3	-1.7	1.1	1.7	0.7	1.0	0.7
Health satisfaction	2.0	2.6	6.0	-1.7	-1.8	-2.5	-1.4	2.2	-1.1	-2.4	-1.0	-1.6	0.1	0.0	-1.9	-0.7
Shortness of breath walking on level ground	0.9	1.0	4.6	-1.0	-0.8	-1.1	-0.9	2.1	-1.0	-1.6	-0.7	-0.6	0.4	-0.0	-0.8	-0.1
Qualifications: College or University degree	5.7	17.9	27.0	4.0	4.7	5.2	4.4	-2.2	4.3	4.8	4.2	4.1	3.2	3.7	4.7	4.6
Eye problems/disorders: None of the above	0.8	0.9	4.9	-1.3	0.2	-1.4	-0.8	2.2	0.1	-0.7	-1.0	0.7	0.5	0.1	0.2	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	3.2	-0.2	0.5	-0.4	-0.3	1.8	0.6	-0.1	-0.7	-0.3	1.2	0.0	-0.2	-0.1
Emphysema/chronic bronchitis	0.5	0.5	2.5	0.8	0.0	-0.6	-0.4	1.5	0.4	-0.4	-1.6	0.3	0.8	-0.5	-0.0	-0.3
Medication for pain relief, constipation, heartburn	2.1	3.6	5.8	2.4	2.4	2.3	1.6	-1.0	2.1	2.2	1.2	2.3	0.9	0.8	2.3	1.7
Neck or shoulder pain in last month	2.5	3.5	6.0	-2.1	-2.4	-2.2	-1.9	0.4	-2.1	-2.2	-1.5	-1.4	-2.1	-1.4	-1.7	-1.9
Medication: Blood pressure	0.4	0.7	1.7	-0.1	-1.1	-0.5	-0.2	0.1	-0.6	-0.5	-1.2	-1.2	-0.1	-0.9	-1.1	-1.3
Angina (self-reported)	3.6	4.7	7.9	-2.0	-1.8	-2.5	-2.8	2.1	-2.5	-2.5	-1.5	-2.5	-1.4	-1.6	-2.5	-1.9
Migraine (self-reported)	0.1	0.2	0.5	-0.7	-0.6	0.1	0.5	-0.2	0.4	0.3	-0.6	-0.3	0.2	0.0	-0.3	-0.5
Medication: Ibuprofen	0.4	0.4	1.0	-1.0	-0.8	-0.8	-0.2	-0.4	-0.7	-0.9	0.1	-0.4	-0.7	-0.3	-0.9	-0.5
Medication: Allopurinol	1.6	2.1	6.4	-0.0	0.3	-1.3	-1.7	1.6	-0.7	-0.9	-2.3	-1.0	-1.0	-2.5	-1.3	-1.9
Medication: Omeprazole	1.1	1.4	2.9	-0.9	-1.4	-0.7	-1.1	-0.8	-1.0	-0.5	-1.2	-0.9	-1.7	-1.6	-1.0	-1.7
Medication: Seretide 50 evohaler	0.4	0.5	1.4	-1.2	-1.0	-0.8	-0.0	0.8	0.4	-0.3	-0.4	0.4	0.9	1.0	0.2	0.3
Mean time to correctly identify matches	1.6	3.1	5.4	-1.1	-1.5	-2.2	-1.7	1.6	-2.1	-2.2	-1.7	-2.3	-0.6	-1.1	-2.3	-1.4
Heart disease (mother)	1.2	1.4	3.5	-1.7	-1.9	-1.3	-1.2	0.3	-1.4	-1.4	-0.7	-1.0	-0.9	-0.6	-1.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	6.2	2.5	1.4	1.4	1.0	-0.1	0.7	1.2	0.7	1.4	1.7	0.9	1.5	1.6
Whole body fat mass	2.7	11.2	21.8	-4.5	-3.2	-3.7	-2.9	1.9	-2.4	-3.7	-2.4	-4.3	-2.1	-2.5	-4.7	-3.7
Leg fat mass (right)	2.2	8.4	18.7	-4.1	-2.4	-3.1	-2.3	1.4	-1.6	-3.0	-2.0	-4.1	-1.8	-2.2	-4.3	-3.4
Arm predicted mass (right)	1.3	6.6	24.9	-5.0	-2.6	-3.7	-1.4	2.6	-0.1	-2.9	-1.6	-3.0	-0.4	0.2	-3.1	-1.6
Pulse rate, automated reading	0.5	1.5	5.6	-2.2	-2.4	-1.7	-0.5	-0.2	-1.2	-1.5	-0.0	-0.8	-0.2	1.0	-0.9	-0.1
Alcohol intake frequency.	0.4	0.9	3.8	-1.2	-0.7	0.2	0.4	-1.9	-0.5	-0.1	1.0	-1.2	-0.8	-0.2	-1.2	-0.9
Comparative height size at age 10	1.0	5.4	10.2	-3.2	-1.8	-3.1	-2.5	2.5	-1.3	-2.3	-2.0	-3.0	-0.9	-1.1	-2.7	-2.2
Number of full sisters	1.4	1.7	4.8	-1.1	-0.7	-1.4	-1.6	1.5	0.1	-0.9	-2.2	-1.3	-0.3	-1.3	-1.2	-1.7
Suffer from ‘nerves’	0.2	0.3	1.4	1.2	0.8	0.9	0.2	-0.6	0.6	0.4	0.3	0.4	-0.2	-0.5	0.2	-0.1
Overall health rating	2.5	5.3	9.4	-2.6	-2.9	-2.8	-2.3	1.0	-2.2	-3.1	-1.4	-2.2	-1.8	-1.5	-2.9	-2.3
Chest pain or discomfort	2.1	3.0	5.9	-1.8	-2.4	-1.7	-2.1	0.7	-2.1	-2.1	-1.2	-1.4	-1.8	-1.3	-1.6	-1.6
Had major operations	2.9	3.4	5.3	-2.3	-1.3	-2.1	-2.2	1.7	-0.8	-1.5	-2.3	-2.2	-1.4	-1.8	-1.9	-2.1
Age at last live birth	2.5	3.6	7.5	0.5	1.8	1.7	2.2	-1.1	1.8	1.7	2.7	1.9	1.3	2.4	1.9	2.4
Family relationship satisfaction	0.8	0.9	2.4	-0.4	0.4	-0.9	-1.1	1.6	0.4	-0.8	-1.3	-1.0	-0.2	-1.2	-1.1	-1.1
Leg pain on walking	0.2	0.3	1.2	-1.1	-0.6	-0.1	0.2	-0.8	0.4	-0.2	0.5	-0.2	-0.6	0.4	-0.3	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.9	0.8	0.0	0.1	-0.3	0.7	0.5	0.2	-1.4	0.3	0.7	-0.5	0.3	-0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.3	0.3	-0.3	-0.0	-0.9	-0.1	-0.1	-0.3	-1.5	-0.7	-0.5	-1.8	-1.1	-1.4
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.1	0.8	0.3	1.0	1.0	-0.3	0.3	0.9	1.0	1.3	0.7	1.2	1.5	1.4
Medication: Aspirin	0.6	0.8	2.8	-0.8	-0.8	-0.7	-0.7	0.5	-1.1	-0.7	-0.5	-1.7	-0.4	-0.7	-1.3	-1.0
Supplements: Vitamin C	0.6	0.7	1.8	-0.8	-0.1	-1.2	-1.0	1.4	-0.7	-1.3	-0.4	-0.8	-0.2	-0.4	-0.9	-0.4
Knee pain experienced in last month	0.8	1.2	2.5	-1.4	-1.2	-1.6	-0.9	0.7	-1.3	-1.2	-0.7	-1.1	-0.9	-0.5	-1.2	-0.8
Hypertension (Self-reported)	0.3	0.9	3.9	-0.5	-0.9	-1.1	-0.9	1.4	0.0	-0.8	-2.0	-0.5	-0.2	-1.0	-0.6	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	6.2	-0.4	-0.3	0.1	-0.7	-1.0	-0.0	0.2	-1.4	-1.2	-1.5	-2.5	-1.4	-2.3
Illnesses of father: Heart disease	0.5	0.7	2.4	-0.2	-1.6	-0.8	-0.5	0.3	-0.2	-0.6	-1.5	-0.6	-0.4	-0.8	-0.6	-1.1
Illnesses of siblings: Diabetes	0.5	0.6	3.5	0.0	-0.2	-0.3	-0.3	0.4	0.3	0.3	-1.9	-0.8	-0.1	-1.1	-0.4	-1.1
Smoking status: Previous	2.1	3.2	5.2	-1.9	-0.9	-2.2	-2.3	1.2	-1.3	-2.3	-1.0	-1.4	-1.8	-2.0	-2.2	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	5.6	-2.1	-1.9	-2.4	-2.3	2.0	-1.8	-2.2	-1.3	-1.3	-1.7	-1.7	-1.7	-1.6
Whole body fat-free mass	1.6	9.3	31.5	-5.6	-3.3	-4.5	-1.9	3.3	-0.9	-3.6	-1.9	-3.4	-0.3	0.3	-3.5	-1.8
Leg fat-free mass (right)	2.1	11.5	38.0	-6.2	-4.1	-4.8	-2.1	3.5	-1.7	-4.2	-1.9	-3.6	-0.3	0.3	-3.8	-1.9
Arm fat percentage (left)	2.5	9.8	19.8	-3.9	-2.7	-3.3	-2.7	1.8	-2.7	-3.5	-2.1	-4.1	-2.0	-2.5	-4.5	-3.5
Average weekly red wine intake	5.4	7.9	14.6	3.8	3.8	3.4	2.2	-0.7	3.7	3.3	1.5	3.0	2.2	1.4	3.1	2.3
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.9	-0.5	-1.0	-0.1	0.1	0.4	-0.2	-0.2	0.0	-0.2	0.6	0.5	-0.2	0.2
Mood swings	1.1	2.1	5.9	-1.3	-1.1	-1.2	-1.1	-0.0	-2.4	-1.6	-0.2	-1.8	-1.2	-1.3	-2.1	-1.4
Loneliness, isolation	0.8	1.1	3.8	-0.8	0.1	0.2	-0.1	-1.9	-0.6	-0.1	0.8	-1.3	-1.1	-1.1	-1.6	-1.5
Long-standing illness, disability or infirmity	1.1	1.7	3.0	-1.4	-1.6	-1.7	-1.2	1.1	-0.9	-1.3	-1.5	-1.7	-0.5	-0.5	-1.6	-1.2
Ever had bowel cancer screening	2.1	2.5	10.4	-1.9	-1.3	-1.0	-0.5	-0.7	-1.1	-1.0	0.1	-3.2	-1.8	-0.6	-2.4	-1.7
Diabetes diagnosed by doctor	0.2	0.3	0.8	0.2	-0.5	-0.3	0.3	0.5	0.6	-0.4	-0.9	-0.7	0.6	-0.1	-0.7	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	1.3	0.3	0.6	0.6	-0.3	0.2	-0.4	-0.0	1.1	0.5	0.3	0.2	0.2	0.7
Friendships satisfaction	0.3	0.4	1.1	-0.9	0.3	-0.1	0.6	0.2	0.9	-0.1	1.0	-0.7	0.6	1.0	-0.5	0.4
Qualifications: nursing, teaching	0.6	1.0	3.4	0.6	1.6	1.2	1.1	-0.4	1.9	1.2	0.6	0.4	0.5	0.6	0.7	0.7
Commuting to job workplace: Walk	0.9	1.0	3.7	-0.6	0.4	0.3	1.2	-1.6	0.6	0.8	1.9	0.6	0.1	1.2	0.7	0.7
Eye problems/disorders: Cataract	0.8	0.9	2.1	0.2	-1.1	0.3	-0.7	-1.3	-1.2	-0.4	0.1	-1.1	-1.5	-1.1	-1.0	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.7	-1.6	-0.0	-1.2	-1.3	1.5	-0.8	-1.1	-0.4	-1.4	-0.9	-0.9	-1.4	-0.8
Medication for cholesterol	2.5	3.8	6.6	2.1	1.8	2.6	1.7	-2.4	0.9	2.2	2.4	2.5	0.5	1.0	2.2	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.6	-1.2	-1.1	-1.5	-1.0	0.3	-1.5	-1.6	-0.1	-1.2	-1.2	-0.6	-1.5	-0.8
Back pain experienced in last month	1.7	2.4	4.1	-1.6	-1.8	-1.5	-2.0	1.6	-1.9	-1.9	-1.5	-1.1	-1.0	-1.2	-1.3	-1.3
Mineral and other dietary supplements	0.8	1.0	2.7	-1.2	-1.1	-0.5	-0.8	-0.8	-1.0	-0.8	-0.2	-0.6	-1.6	-1.2	-1.0	-1.4
Breast cancer (self-reported)	1.8	2.2	4.4	1.4	1.2	2.1	1.7	-2.1	2.0	1.9	0.7	1.5	0.3	0.4	1.5	0.7
Asthma (self-reported)	0.2	0.4	1.5	-0.4	-0.8	0.2	0.8	-0.1	1.2	0.6	-1.0	-0.1	0.6	0.5	0.3	-0.2
Osteoporosis (self-reported)	0.7	0.8	2.2	0.9	0.6	1.5	0.9	-0.8	0.0	1.0	1.3	0.7	0.6	0.9	0.9	1.0
Osteoarthritis (self-reported)	0.5	0.6	1.9	-1.3	-1.3	-0.4	0.6	-0.6	0.0	-0.3	-0.1	-1.4	0.1	0.3	-1.1	-0.6
Medication: Aspirin	0.4	0.5	1.4	-0.6	-0.9	-0.7	-0.3	0.5	-0.7	-0.5	-0.7	-1.2	-0.1	-0.4	-0.9	-0.8
Medication: Gliclazide	1.0	1.1	4.6	-0.3	-0.6	0.5	1.8	-1.1	0.3	0.4	1.3	-0.4	1.3	2.1	0.2	1.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	1.0	0.5	0.5	0.4	-0.4	0.4	0.4	0.9	1.2	0.6	1.0	0.7	1.1
Smoking status: Current	1.6	2.6	11.0	-1.6	-2.5	-1.2	-1.5	0.8	-3.3	-2.2	-0.3	-1.1	-0.8	-0.7	-1.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	2.3	-0.7	-0.2	0.1	0.0	-0.5	-0.3	-0.3	1.5	0.6	-0.9	0.4	0.3	0.7
Whole body water mass	1.7	9.4	31.5	-5.6	-3.3	-4.5	-1.9	3.4	-0.9	-3.6	-2.0	-3.4	-0.3	0.3	-3.5	-1.7
Leg predicted mass (right)	2.2	11.6	37.9	-6.2	-4.1	-4.9	-2.1	3.5	-1.7	-4.2	-1.9	-3.5	-0.3	0.3	-3.8	-1.9
Arm fat mass (left)	2.6	10.5	22.7	-4.8	-3.1	-3.8	-2.6	2.4	-2.1	-3.7	-2.4	-4.1	-1.6	-2.0	-4.4	-3.3
Number of self-reported non-cancer illnesses	1.5	2.6	7.1	-1.5	-1.6	-1.2	-0.9	0.4	-0.0	-0.8	-2.5	-2.1	-0.9	-1.8	-1.9	-2.7
Average weekly champagne plus white wine intake	0.7	1.0	3.5	-1.8	-0.4	-0.2	0.1	-1.1	-0.6	-0.4	1.9	-1.1	-1.2	0.5	-0.8	0.0
Miserableness	0.5	0.8	3.3	1.3	1.8	1.0	0.7	-1.1	-0.3	0.8	1.2	0.2	0.3	-0.2	0.2	0.2
Guilty feelings	0.2	0.3	1.4	-0.6	1.2	0.1	-0.4	0.2	0.1	-0.3	0.9	-0.6	-0.5	-0.3	-0.6	-0.2
Wears glasses or contact lenses	1.2	1.4	4.3	0.7	0.1	1.3	2.1	-1.9	1.2	1.6	0.9	-0.1	1.0	1.4	0.6	0.6
Ever taken oral contraceptive pill	0.7	0.8	2.1	-0.8	-0.4	-0.8	-1.3	1.0	-1.4	-1.1	-0.7	-0.8	-0.6	-0.9	-0.7	-0.8
Hearing aid user	2.6	2.9	7.3	1.2	1.8	1.8	1.5	-0.6	2.7	2.3	0.5	2.0	1.1	1.1	2.3	1.6
Mother’s age at death	0.5	0.7	2.8	0.5	1.1	-0.7	-0.7	1.7	0.4	-0.2	-1.1	-0.9	0.2	-0.8	-0.6	-0.6
Financial situation satisfaction	0.2	0.3	1.1	-0.2	0.9	-0.2	0.2	0.5	0.3	-0.2	1.0	0.1	0.7	0.6	-0.1	0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	0.3	-0.4	-0.1	0.2	0.5	1.0	-0.0	-1.0	0.8	0.6	0.2	0.6	0.0
Commuting to job workplace: Public transport	0.9	1.1	3.9	0.2	0.6	0.6	1.0	0.4	0.4	0.8	1.0	0.4	1.6	2.0	1.2	1.6
Eye problems/disorders: Glaucoma	0.6	0.7	2.1	0.4	0.4	0.9	1.4	-0.5	1.0	0.8	0.9	-0.8	1.2	1.2	0.0	0.6
Medication: Blood pressure	0.3	0.6	2.9	-0.4	0.5	-0.5	-0.5	1.7	1.2	0.1	-1.3	0.4	0.6	-0.1	0.5	0.1
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.1	-1.6	-2.0	-1.4	-1.0	0.3	-1.2	-1.7	-0.4	-1.1	-1.1	-0.5	-1.6	-1.0
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.3	1.4	2.0	0.4	0.6	1.8	1.3	0.7	0.1	0.9	2.1	1.1	1.2	1.6
High cholesterol (Self-reported)	0.7	1.2	5.0	-0.6	-2.2	-1.5	-0.6	0.6	-0.0	-0.8	-2.0	-0.8	-0.4	-0.3	-0.8	-1.0
Medication: Bendroflumethiazide	0.3	0.5	1.7	0.5	0.3	0.5	0.5	0.4	1.1	0.6	-0.5	1.3	0.4	0.1	1.0	0.5
Medication: Paracetamol	1.8	2.8	6.3	-2.0	-2.0	-1.8	-1.5	0.7	-2.5	-2.2	-0.2	-1.8	-1.5	-0.8	-1.8	-1.3
Medication: Lisinopril	0.3	0.3	1.8	0.4	-0.8	-0.5	0.3	0.7	-0.2	-0.2	-1.4	-0.3	0.6	0.4	0.1	0.1
Medication: Atorvastatin	0.4	0.5	1.6	-0.4	-1.3	-0.7	-0.2	0.3	-0.3	-0.5	-0.9	-1.2	0.3	0.1	-1.0	-0.5
Illnesses of father: High blood pressure	1.4	1.8	6.1	-0.2	0.3	-0.3	-1.7	0.5	-1.4	-0.8	-0.8	-1.3	-1.7	-2.5	-1.4	-1.9
Alcohol drinker status: Never	1.7	2.1	5.0	-0.1	0.7	1.6	2.0	-1.6	0.9	1.6	2.2	0.2	1.4	2.2	0.8	1.5
Ever smoked	1.9	3.3	7.4	-1.4	-1.1	-2.2	-2.5	1.9	-2.1	-2.7	-1.1	-0.8	-1.3	-2.0	-1.8	-1.6
Basal metabolic rate	1.9	10.4	33.1	-5.8	-3.4	-4.5	-2.2	3.3	-1.2	-3.9	-2.0	-3.6	-0.6	-0.2	-3.9	-2.1
Leg fat percentage (left)	1.2	4.4	9.9	-2.4	-1.6	-1.8	-1.8	0.5	-1.5	-2.1	-1.5	-2.6	-1.8	-2.4	-3.1	-2.7
Arm fat-free mass (left)	1.4	7.3	24.5	-4.9	-2.7	-3.9	-1.6	3.3	-0.3	-3.1	-2.0	-2.9	0.0	0.2	-3.0	-1.5
Number of operations (self-reported)	1.3	1.9	4.1	-1.7	-1.0	-1.2	-1.4	0.7	-0.6	-1.1	-1.5	-1.8	-0.9	-1.5	-1.8	-2.0
Average weekly beer plus cider intake	1.1	1.5	7.6	-0.1	-1.6	-1.2	-1.2	1.3	-1.0	-0.9	-2.8	-0.1	-0.5	-1.3	-0.3	-1.1
Irritability	2.1	3.6	6.0	-1.6	-1.2	-1.7	-2.1	0.8	-2.4	-1.8	-1.5	-2.3	-2.2	-2.2	-2.2	-2.1
Risk taking	2.2	3.2	8.4	-1.3	-1.9	-1.3	-1.6	-0.2	-2.9	-2.2	-0.2	-1.9	-2.0	-1.6	-2.4	-1.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.5	1.0	0.4	1.2	1.5	-1.3	1.6	1.4	0.9	1.0	0.4	1.5	1.3	1.4
Fractured/broken bones in last 5 years	1.8	2.4	4.2	-1.1	-0.7	-1.7	-2.1	1.1	-1.4	-1.6	-1.4	-1.3	-1.4	-2.0	-1.7	-1.8
Age started oral contraceptive pill	0.9	1.1	3.8	-0.2	0.7	0.8	1.6	-1.0	1.9	1.6	0.3	0.0	0.8	1.4	0.9	0.6
Diastolic blood pressure, automated reading	0.8	2.4	4.3	-1.3	-1.4	-1.8	-1.7	1.5	-1.4	-1.7	-2.1	-1.6	-1.0	-1.3	-1.5	-1.6
Ever depressed for a whole week	0.2	0.3	1.3	-0.7	0.1	0.2	-0.1	-0.9	-0.4	-0.3	1.2	-0.7	-0.4	0.1	-0.5	-0.2
Unable to work because of sickness or disability	8.4	10.8	16.6	-2.6	-3.5	-3.9	-3.9	3.0	-3.7	-4.1	-3.5	-2.6	-2.1	-2.8	-3.3	-3.2
Commuting to job workplace: Cycle	0.3	0.3	1.4	-0.1	0.9	0.0	-0.0	0.7	-0.4	0.1	1.2	0.4	0.4	0.7	0.4	0.8
Myopia	1.5	2.2	9.2	-0.7	-1.0	-1.3	0.9	1.7	0.4	-0.4	0.3	1.0	2.1	3.0	1.2	2.3
Vascular/heart problems diagnosed by doctor	0.9	2.4	7.5	0.8	1.7	1.7	1.7	-1.7	0.5	1.5	2.7	1.0	0.6	1.6	1.3	1.8
Cholesterol lowering medication	3.9	5.8	11.7	-2.8	-2.8	-3.4	-2.1	2.6	-1.5	-2.9	-2.7	-2.6	-0.9	-1.0	-2.6	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	3.2	-0.9	-1.2	-0.9	-1.1	-0.3	-1.1	-0.9	-1.1	-1.4	-1.5	-1.7	-1.4	-1.8
Pain experienced in last month	1.5	2.5	4.5	2.1	1.5	1.8	1.4	-0.2	2.1	1.7	0.4	2.0	1.5	0.9	2.1	1.4
Supplements: Calcium	0.5	0.5	1.3	0.2	0.2	0.4	0.7	-0.4	1.0	0.6	0.1	0.9	0.3	1.1	1.0	1.1
Basal cell carcinoma (self-reported)	0.9	1.1	5.1	-1.5	-0.7	0.2	0.7	-1.6	-0.6	-0.1	2.3	0.3	-0.6	1.3	0.2	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.9	-1.4	-0.3	0.0	0.1	-0.5	-0.5	-0.1	1.4	-0.6	-0.3	0.4	-0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	5.8	-2.4	-1.7	-1.6	-0.9	-0.0	-1.9	-1.8	-0.3	-1.8	-1.1	-0.9	-2.1	-1.4
Heart disease (siblings)	0.5	0.6	3.2	1.8	0.1	0.3	-0.4	-0.6	-0.7	-0.1	-0.4	0.1	-0.7	-1.3	-0.1	-0.9
Alcohol drinker status: Previous	1.0	1.1	3.3	-1.2	-1.8	-1.3	-0.9	0.7	-1.1	-1.4	-0.5	-0.9	-0.5	-0.2	-1.1	-0.6
Pack years of smoking	2.8	4.0	8.2	-1.6	-1.7	-2.1	-1.5	1.3	-2.2	-2.3	-2.0	-2.9	-0.8	-1.8	-2.8	-2.2
Impedance of whole body	0.6	2.9	10.4	3.2	2.1	2.1	-1.2	-1.6	-1.4	1.4	0.7	1.1	-1.5	-2.4	1.0	-0.5
Leg fat mass (left)	2.1	8.2	18.1	-4.3	-2.7	-3.1	-2.2	1.4	-1.7	-3.1	-1.9	-3.8	-1.7	-2.0	-4.2	-3.2
Arm predicted mass (left)	1.5	7.8	27.9	-5.3	-2.9	-4.0	-1.6	3.0	-0.4	-3.2	-2.0	-3.1	-0.3	0.1	-3.2	-1.7