[Hub]/) : Traits : Waist Hip Ratio (WHR) : ← →

chr10:4,129,296-5,953,148

Best TWAS P=1.47e-15 · Best GWAS P=4.06e-13 conditioned to 0.687

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AKR1C2	0.31	0.06	bslmm	665	0.16	2.1e-19	3.5	-5.6	2.1e-08	0.72	0.21	0.79	FALSE
2	GTEx	Artery Tibial	AKR1C2	0.14	0.10	enet	10	0.15	1.2e-11	-7.2	-7.6	4.0e-14	0.95	0.00	1.00	FALSE
3	GTEx	Artery Tibial	AKR1E2	0.27	0.00	lasso	10	0.04	1.9e-04	1.8	5.3	1.0e-07	-0.29	0.92	0.01	FALSE
4	GTEx	Brain Cerebellar Hemisphere	AKR1C1	0.46	0.14	lasso	4	0.23	1.4e-06	-3.4	5.6	2.1e-08	-0.82	0.01	0.96	FALSE
5	GTEx	Brain Cerebellum	AKR1C2	0.27	0.04	enet	12	0.11	4.1e-04	-7.1	-7.9	3.1e-15	0.70	0.01	0.97	FALSE
6	GTEx	Brain Cortex	AKR1C2	0.49	0.10	lasso	11	0.26	1.1e-07	-7.1	-5.9	3.1e-09	0.83	0.01	0.98	FALSE
7	GTEx	Brain Hippocampus	AKR1C2	0.35	0.13	lasso	9	0.16	1.3e-04	-5.3	-6.3	3.1e-10	0.51	0.07	0.78	FALSE
8	GTEx	Cells Transformed fibroblasts	AKR1C2	0.28	0.23	lasso	6	0.21	1.9e-15	-7.1	-6.9	5.0e-12	0.96	0.01	0.99	FALSE
9	GTEx	Esophagus Muscularis	AKR1C2	0.30	0.21	lasso	2	0.19	8.5e-12	-7.1	-7.1	1.4e-12	0.96	0.00	1.00	FALSE
10	GTEx	Heart Atrial Appendage	AKR1C2	0.28	0.37	lasso	3	0.29	1.2e-13	-7.2	-7.2	6.3e-13	0.99	0.00	1.00	FALSE
11	GTEx	Ovary	AKR1C3	0.35	0.20	lasso	9	0.22	3.9e-06	-7.1	-7.6	2.8e-14	0.88	0.01	0.96	FALSE
12	GTEx	Skin Sun Exposed Lower leg	AKR1C2	0.17	0.18	lasso	2	0.18	4.0e-15	-7.1	-7.1	1.2e-12	0.96	0.00	1.00	FALSE
13	GTEx	Testis	AKR1C2	0.44	0.36	lasso	4	0.36	8.5e-17	-7.1	-7.0	3.2e-12	0.97	0.00	1.00	FALSE
14	GTEx	Testis	AKR1C1	0.28	0.04	enet	39	0.07	3.7e-04	-7.3	5.1	2.7e-07	-0.62	0.01	0.94	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	AKR1C2	0.56	0.40	enet	28	0.46	1.0e-65	-7.1	-8.0	1.5e-15	0.93	0.01	0.99	TRUE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKR1C1	0.07	0.04	enet	10	0.02	1.0e-03	-7.3	7.4	1.1e-13	-0.90	0.00	0.99	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKR1C2	0.12	0.11	lasso	6	0.09	1.6e-10	-7.1	-7.2	8.6e-13	0.97	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKR1C2	0.29	0.21	lasso	1	0.21	4.7e-12	-7.2	-7.2	7.2e-13	0.99	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKR1C2	0.09	0.05	blup	62	0.05	3.4e-06	-7.3	-7.2	7.4e-13	0.90	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASB13	0.04	0.02	enet	6	0.03	2.6e-04	-5.9	-5.1	2.8e-07	-0.08	0.00	0.99	TRUE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	AKR1C2	0.39	0.18	enet	14	0.23	2.5e-23	-7.1	-7.4	1.4e-13	0.85	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	AKR1E2	0.07	0.01	lasso	4	0.04	6.3e-05	4.4	6.6	3.7e-11	-0.36	0.35	0.04	TRUE
23	The Cancer Genome Atlas	Soft Tissue Sarcoma	AKR1C2	0.07	0.04	enet	5	0.06	1.1e-04	-3.4	-5.8	5.7e-09	0.74	0.01	0.83	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	AKR1C2	0.09	0.08	lasso	3	0.08	7.2e-08	-7.3	-7.5	7.4e-14	0.93	0.00	1.00	FALSE