Best TWAS P=2.94e-13 · Best GWAS P=7.6e-11 conditioned to 0.543
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | EIF2S2P3 | 0.09 | 0.04 | lasso | 6 | 0.04 | 1.1e-03 | -5.7 | -6.5 | 1.1e-10 | -0.01 | 0.01 | 0.95 | TRUE |
| 2 | GTEx | Liver | NOC3L | 0.23 | -0.01 | enet | 31 | 0.06 | 9.2e-03 | -5.7 | 5.1 | 2.9e-07 | 0.01 | 0.03 | 0.69 | TRUE |
| 3 | GTEx | Nerve Tibial | PLCE1 | 0.35 | 0.11 | enet | 25 | 0.23 | 2.1e-16 | 5.1 | -5.1 | 2.8e-07 | -0.08 | 0.60 | 0.40 | FALSE |
| 4 | GTEx | Prostate | EIF2S2P3 | 0.21 | 0.05 | lasso | 4 | 0.11 | 1.1e-03 | -5.7 | -5.3 | 1.2e-07 | 0.03 | 0.02 | 0.72 | FALSE |
| 5 | GTEx | Thyroid | EIF2S2P3 | 0.15 | 0.14 | lasso | 2 | 0.14 | 6.2e-11 | -5.7 | -5.3 | 9.0e-08 | -0.01 | 0.01 | 0.99 | FALSE |
| 6 | METSIM | Adipose | FFAR4 | 0.05 | 0.02 | lasso | 6 | 0.02 | 2.4e-04 | 5.4 | 5.8 | 5.2e-09 | 0.40 | 0.16 | 0.83 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | FFAR4 | 0.11 | 0.03 | lasso | 5 | 0.04 | 4.2e-06 | 5.7 | 7.3 | 2.9e-13 | 0.83 | 0.00 | 1.00 | TRUE |