TWAS hub - PLCE1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.217	0.0400	4.8e-12	0.186	0.111	0.170	0.177	0.178	4.6e-22	2.2e-13	3.8e-20	4.4e-21	3.4e-21
2	GTEx	Adipose Subcutaneous	0.145	0.0440	3.8e-04	0.062	NA	0.055	NA	0.065	8.8e-06	NA	2.9e-05	NA	4.9e-06
3	GTEx	Adipose Visceral Omentum	0.238	0.0630	2.0e-05	0.052	NA	0.083	NA	0.082	1.0e-03	NA	4.3e-05	NA	4.7e-05
4	GTEx	Cells Transformed fibroblasts	0.154	0.0440	3.9e-05	0.104	NA	0.057	NA	0.075	3.1e-08	NA	4.2e-05	NA	2.7e-06
5	GTEx	Colon Transverse	0.140	0.0550	1.9e-03	0.069	NA	0.032	NA	0.052	3.6e-04	NA	1.1e-02	NA	1.7e-03
6	GTEx	Nerve Tibial	0.352	0.0563	1.8e-12	0.111	NA	0.232	NA	0.211	3.0e-08	NA	2.1e-16	NA	6.0e-15
7	GTEx	Skin Not Sun Exposed Suprapubic	0.110	0.0500	9.6e-03	0.088	NA	0.067	NA	0.074	1.5e-05	NA	1.5e-04	NA	7.1e-05
8	METSIM	Adipose	0.117	0.0264	9.5e-14	0.131	0.102	0.125	0.123	0.123	4.5e-19	6.0e-15	3.0e-18	7.1e-18	6.8e-18
9	ROSMAP	Brain Pre-frontal Cortex	0.198	0.0455	1.1e-09	0.044	0.084	0.076	0.079	0.071	2.4e-06	5.8e-11	4.9e-10	2.2e-10	1.9e-09
10	TCGA	Breast Invasive Carcinoma	0.106	0.0285	0.0e+00	0.091	0.100	0.082	NA	0.089	5.4e-18	1.1e-19	1.8e-16	NA	9.5e-18
11	TCGA	Brain Lower Grade Glioma	0.127	0.0373	4.0e-09	0.085	0.089	0.095	NA	0.088	6.2e-10	2.7e-10	6.1e-11	NA	3.7e-10
12	TCGA	Prostate Adenocarcinoma	0.113	0.0408	1.8e-05	0.009	0.052	0.028	NA	0.029	3.5e-02	3.9e-06	5.5e-04	NA	5.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Impedance of leg (right)	6.0	28.8	81.6	-4.0	-0.9	-3.5	-4.6	-4.4	-9.0	-7.7	-4.8	-0.9	-7.6	-4.3	-6.1
Impedance of leg (left)	5.6	27.3	77.6	-3.9	-0.7	-2.7	-4.6	-4.2	-8.8	-7.4	-4.3	-1.0	-7.6	-4.1	-6.3
Impedance of whole body	5.3	27.1	70.6	-4.1	-0.9	-2.3	-5.0	-4.0	-8.4	-7.3	-3.8	-0.7	-8.0	-4.2	-6.5
Impedance of arm (left)	4.8	22.2	58.1	-4.2	-1.6	-2.4	-4.4	-4.0	-7.6	-6.1	-3.7	-1.0	-6.7	-4.0	-5.8
Mean Putamen Volume	4.0	4.6	15.1	-2.6	-2.2	-1.8	-2.6	-1.9	-1.9	-1.0	-1.0	-1.2	-2.4	-1.4	-3.9
Impedance of arm (right)	4.0	18.9	51.9	-3.2	-0.8	-2.3	-4.1	-3.2	-7.2	-6.1	-3.5	-0.3	-6.5	-3.2	-5.3
Relative age of first facial hair	3.7	7.6	17.7	-4.0	-3.3	-3.5	1.4	-4.2	-3.2	-0.1	-2.2	-2.0	1.6	-3.2	-0.7
Exposure to tobacco smoke outside home	3.7	4.9	11.1	2.6	2.3	2.5	2.5	2.3	1.9	1.3	1.4	0.5	2.4	2.2	3.3
Illnesses of father: Heart disease	3.6	5.0	8.6	2.7	2.9	1.6	1.1	2.7	2.8	2.2	1.5	2.6	0.9	2.3	2.2
Breast cancer (self-reported)	3.3	4.0	10.6	-2.4	-1.6	-1.3	-3.2	-1.4	-0.8	-1.9	0.5	-1.1	-2.4	-2.0	-3.1
Hair/balding pattern: Pattern 3	2.9	4.4	13.3	2.0	3.2	2.2	-0.1	2.1	1.9	1.2	2.4	3.6	-0.2	2.0	0.9
Length of working week for main job	2.9	3.2	6.3	2.3	1.5	1.0	1.3	2.1	2.5	2.4	1.6	1.0	1.3	1.5	2.1
Loud music exposure frequency	2.7	3.0	6.4	1.9	1.9	0.6	1.9	1.7	1.6	1.4	1.1	2.3	1.8	1.1	2.5
Shortness of breath walking on level ground	2.7	3.2	6.9	1.9	1.8	0.8	1.0	1.7	2.3	2.2	1.5	0.7	0.9	2.6	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.5	12.8	0.6	1.7	3.2	-2.9	2.0	2.0	-0.5	3.1	3.6	-2.7	0.2	-2.3
Waist Hip Ratio (WHR)	2.5	11.3	26.3	-2.9	-3.3	-4.4	1.0	-4.2	-5.1	-2.9	-5.0	-3.8	0.5	-2.0	-0.4
Lung FVC	2.5	12.9	34.3	1.5	3.8	4.7	-4.1	3.6	4.7	-0.2	5.9	3.3	-3.4	2.5	-1.2
Medication: Omeprazole	2.5	3.0	5.9	1.6	1.7	1.0	1.4	1.7	2.2	2.1	1.8	1.2	1.0	1.9	2.4
Medication: Omeprazole (e.g. Zanprol)	2.4	3.0	5.0	1.9	1.8	1.3	0.8	2.0	2.2	2.2	1.8	1.5	0.5	1.7	2.0
Emphysema/chronic bronchitis	2.3	2.6	8.4	1.7	1.6	0.8	1.3	1.6	1.0	1.2	0.8	0.5	1.4	2.9	2.7
HbA1C	2.2	2.4	6.9	-1.5	-2.1	-1.6	0.7	-2.6	-1.4	0.3	-2.1	-1.1	1.0	-1.9	0.1
Commuting to job workplace: Walk	2.2	2.4	4.0	-1.7	-1.9	-2.0	-0.2	-1.6	-1.9	-1.4	-1.6	-1.9	0.4	-1.9	-0.7
Medication: Bendroflumethiazide	2.2	3.4	8.7	-1.1	-1.0	-2.3	0.0	-2.0	-2.9	-2.5	-2.9	-2.2	-0.5	-0.7	-0.4
Forced vital capacity (FVC), Best measure	2.1	7.6	17.3	-0.2	1.6	3.2	-4.0	1.6	2.0	-1.9	3.3	4.2	-3.9	1.2	-2.6
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	5.2	1.5	2.0	2.1	0.2	2.0	1.8	1.1	2.3	0.6	0.2	1.0	0.8
Schizophrenia vs Biploar Disorder	2.0	2.7	10.0	-1.7	-2.2	-1.6	-0.3	-1.5	-1.4	-1.1	-1.7	-3.2	0.3	-1.5	-0.8
Father’s age at death	2.0	2.7	7.2	-1.8	-2.5	-2.7	-0.0	-1.9	-0.8	-0.2	-1.6	-2.7	0.6	-1.0	-0.1
Depression (self-reported)	2.0	2.4	5.4	1.3	1.4	2.1	0.9	1.0	1.9	1.8	2.3	-0.3	0.6	1.5	1.9
Migraine (self-reported)	2.0	2.4	5.6	2.1	2.2	1.9	0.5	2.1	0.2	0.0	0.5	2.4	-0.9	2.0	1.2
BMI	1.9	11.2	17.5	3.8	4.0	2.8	1.2	4.1	4.2	2.8	3.2	3.2	2.1	3.6	3.7
Medication: Atenolol	1.9	2.3	7.4	-1.4	-0.2	-0.2	-2.7	-0.7	-1.2	-2.3	0.2	-0.4	-2.7	-0.5	-1.8
Forced vital capacity (FVC)	1.9	7.2	15.1	0.3	2.0	3.2	-3.5	2.1	2.9	-0.8	3.8	3.9	-3.2	1.7	-1.9
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	15.5	0.4	1.7	3.1	-3.4	2.0	2.4	-0.8	3.2	3.9	-3.3	1.0	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.8	17.7	-0.0	1.3	2.9	-3.4	1.4	1.6	-1.5	2.6	4.2	-3.3	0.7	-2.5
Number of children fathered	1.8	2.1	4.8	-1.4	-1.3	-1.6	1.3	-1.8	-1.9	-0.2	-2.2	-0.7	1.5	-1.5	0.3
Prostate Cancer	1.7	2.4	6.2	-2.0	-1.4	-0.7	-2.1	-1.8	-0.6	-1.4	-0.3	-0.3	-1.9	-1.7	-2.5
Body Mass Index (BMI) (2010)	1.7	2.3	5.6	1.6	1.7	1.2	0.7	1.3	2.4	1.3	1.3	0.8	1.3	1.8	2.0
Systolic Blood Pressure	1.7	8.7	29.2	-1.6	2.0	-0.7	-2.8	-0.9	-5.4	-5.1	-0.8	-1.4	-4.5	-0.0	-3.3
Medication: Amlodipine	1.7	2.4	5.3	0.5	2.3	1.4	-2.0	0.8	-0.5	-2.1	0.7	1.7	-2.3	0.7	-1.7
Pack years of smoking	1.7	2.4	6.9	-1.2	-1.3	-2.2	0.6	-1.3	-2.4	-1.5	-2.0	-2.6	-0.0	-0.1	-0.5
Ulcerative Colitis (UC)	1.6	3.0	6.1	2.2	1.9	2.0	-0.4	2.1	2.3	1.0	1.8	1.9	-0.5	2.5	0.5
Medication: Seretide 50 evohaler	1.6	1.8	3.1	1.8	1.7	1.3	0.6	1.6	1.6	1.3	0.9	1.5	0.0	1.7	1.0
Alzheimer’s Disease (including proxy)	1.5	2.1	6.1	-1.5	-1.7	-1.6	0.8	-1.9	-1.3	-0.5	-2.5	-0.5	1.4	-1.9	-0.1
Ulcerative Colitis	1.5	2.1	4.2	1.4	1.7	1.6	-1.0	1.7	2.0	0.8	2.0	0.5	-1.0	2.0	0.1
Average weekly spirits intake	1.5	1.8	6.3	-0.4	-1.1	-1.3	2.3	-0.9	-0.3	1.4	-0.7	-1.1	2.5	-1.0	1.1
Pack years adult smoking proportion	1.5	2.3	6.2	-1.1	-1.5	-2.2	0.9	-1.3	-2.2	-0.9	-2.0	-2.5	0.2	-0.2	-0.4
Birth weight of first child	1.5	2.8	11.6	0.1	-1.8	-0.0	2.5	-0.1	-0.2	1.6	-1.9	3.4	1.6	-1.9	-0.0
Alcohol drinker status: Never	1.5	1.8	5.0	-1.3	-1.1	-2.2	-0.6	-1.4	-1.4	-2.2	-0.6	-1.6	-0.4	-1.0	-0.4
Stomach or abdominal pain in last month	1.4	1.7	7.6	0.9	1.5	0.9	1.2	0.7	1.4	0.1	0.9	-0.0	1.4	1.4	2.8
Number of live births	1.4	2.0	5.7	1.8	1.9	1.3	0.1	1.8	1.1	1.3	1.4	0.1	0.4	2.4	0.8
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	5.5	1.4	1.2	1.9	-2.1	1.6	0.8	-1.2	0.4	2.3	-2.1	0.4	-0.9
Headache pain in last month	1.4	2.3	4.3	2.0	1.9	1.0	2.0	1.6	-0.6	-1.0	-0.7	1.2	1.2	1.8	2.1
Eye problems/disorders: Cataract	1.4	1.7	4.4	-0.4	-0.6	-1.4	2.1	-1.0	-1.6	-0.6	-1.6	-0.6	1.7	-0.2	1.8
Breast Cancer	1.3	3.1	5.2	-1.2	-1.2	-2.1	2.2	-2.3	-1.5	0.6	-1.8	-2.1	2.3	-1.4	1.8
Coronary Artery Disease (CAD)	1.3	1.6	4.1	0.8	1.1	0.9	0.1	0.6	2.0	1.4	1.6	1.7	0.9	1.4	1.2
Hypothyroidism (self reported)	1.3	3.0	6.8	1.0	1.3	2.6	-1.6	1.5	2.5	0.8	2.4	2.4	-1.2	1.4	-0.3
Medication: Co-codamol	1.3	1.5	3.0	1.4	1.1	1.4	1.3	1.3	1.0	1.6	0.5	-0.5	0.7	1.7	1.7
Falls in the last year	1.3	1.8	4.6	2.0	1.7	0.5	2.1	1.5	0.0	0.4	-0.0	-0.7	1.1	1.5	1.9
Number of full brothers	1.3	1.6	3.4	1.1	1.8	1.7	-0.4	1.4	1.1	0.4	1.6	1.8	-0.4	1.3	1.0
Average weekly champagne plus white wine intake	1.3	1.8	4.4	-1.3	-1.9	-1.3	-0.6	-1.1	-1.3	-0.1	-1.8	-0.3	-0.5	-2.1	-1.7
Medication: Blood pressure	1.3	2.5	8.0	-1.0	0.3	-1.4	-2.5	-1.0	-1.8	-2.1	-0.2	-1.0	-2.8	-0.3	-2.0
Medication: Paracetamol	1.3	2.1	5.6	2.3	1.6	-0.1	1.9	1.5	0.6	1.3	0.1	0.7	1.1	1.3	2.4
Alzheimer’s Disease (in mother)	1.2	1.4	4.4	-1.1	-1.3	-1.0	1.0	-1.2	-1.3	-0.0	-2.1	0.3	0.8	-1.8	-0.2
Triglycerides	1.2	2.0	6.7	0.5	2.2	1.0	-1.6	0.9	1.3	-0.3	1.8	2.6	-1.5	0.5	-0.4
Systolic blood pressure, automated reading	1.2	3.4	18.3	-1.2	1.0	-1.6	-0.2	-1.2	-4.3	-2.9	-1.6	-1.3	-1.3	-0.6	-0.8
Medication: Metformin	1.2	1.7	5.1	-0.8	-0.8	-1.9	0.9	-1.8	-2.2	-0.4	-2.2	-0.7	0.5	-0.0	0.6
Qualifications: CSEs or equivalent	1.2	1.6	3.5	-1.7	-1.9	-1.9	-0.8	-1.8	-1.2	-0.3	-0.4	-0.6	-0.8	-1.1	-1.0
Body mass index (BMI)	1.2	5.1	12.7	2.3	2.3	0.9	2.0	2.1	2.5	2.3	1.6	1.5	2.3	2.6	3.6
Exposure to tobacco smoke at home	1.2	1.3	3.4	-0.1	-0.8	-1.9	1.4	-0.8	-1.8	-0.5	-1.4	-1.5	1.1	0.3	0.7
Medication for pain relief, constipation, heartburn	1.2	2.0	4.0	-1.9	-2.0	-1.1	-1.4	-1.7	-0.5	-1.2	-1.0	-1.1	-0.4	-1.7	-2.0
Wears glasses or contact lenses	1.2	1.4	4.7	0.9	0.2	0.5	2.0	0.3	0.7	1.4	-0.4	-0.4	2.2	0.4	2.0
Diastolic blood pressure, automated reading	1.2	3.7	12.1	-1.0	0.7	-0.1	-1.6	-0.3	-3.5	-3.2	-0.9	0.6	-3.0	-1.0	-2.5
Depression (Nagel 2018)	1.1	1.6	3.5	-1.1	-0.9	-1.7	-0.3	-1.9	-1.9	-1.7	-1.4	-1.4	-0.1	-0.2	-0.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.2	-1.0	-1.3	-0.8	0.1	-0.9	-1.4	-1.1	-1.5	-1.3	-0.9	-1.2	-1.4
Cardiovascular Disease	1.1	3.7	10.4	1.2	3.2	1.1	-2.3	1.4	-1.3	-2.2	0.5	1.3	-3.2	1.3	-1.7
Lung FEV1/FVC ratio	1.1	5.8	18.9	-2.3	-3.4	-2.3	-0.2	-2.5	-2.6	-0.6	-3.4	-0.3	-0.1	-4.3	-1.9
Hand grip strength (left)	1.1	2.9	7.9	0.7	1.5	2.4	-0.9	1.5	2.4	0.9	2.5	2.8	-0.7	1.4	0.3
Diabetes (father)	1.1	1.4	3.9	-0.9	-1.1	-1.8	1.4	-1.0	-2.0	-0.7	-1.8	-0.6	0.6	-0.8	0.2
Current tobacco smoking	1.1	1.7	3.8	-1.4	-1.9	-1.3	0.2	-1.7	-1.5	0.3	-1.2	-1.6	0.5	-1.7	-1.0
Maternal smoking around birth	1.1	1.7	5.0	1.4	0.8	0.4	2.2	0.3	-0.3	0.9	-1.3	-0.7	1.7	1.3	2.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.4	1.2	1.1	-0.8	2.0	0.4	-0.1	0.4	-0.8	-0.2	2.1	1.9	2.1
Hair/balding pattern: Pattern 2	1.1	1.4	4.2	-1.0	-1.2	-1.4	0.3	-0.9	-1.8	-1.2	-1.7	-2.0	-0.0	-0.3	-0.2
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.3	-1.3	-1.5	0.7	-1.8	-0.7	-0.2	-1.0	-0.3	-1.1	-1.5	-0.9	-1.8
Hip circumference	1.1	4.6	9.8	2.3	3.1	1.9	0.3	2.8	2.0	1.2	2.3	2.2	0.1	3.1	1.9
Qualifications: College or University degree	1.1	3.5	11.8	2.4	2.0	3.4	0.6	2.9	1.4	0.4	1.6	2.1	-0.3	1.5	0.4
Heart disease (mother)	1.1	1.4	4.6	1.8	1.5	1.1	-0.1	1.7	0.9	-0.6	0.7	-0.6	-0.1	2.1	0.9
Suffer from ‘nerves’	1.1	1.7	3.5	1.4	1.6	1.7	-0.2	1.4	1.7	0.7	1.5	-1.2	-0.1	1.9	1.1
Leg fat-free mass (right)	1.1	5.9	22.1	1.2	-0.2	1.8	1.3	1.8	4.7	3.5	2.5	1.6	3.2	1.9	2.2
Friendships satisfaction	1.1	1.3	5.5	-1.4	-1.1	-1.1	0.0	-1.5	-2.4	0.1	-1.4	-0.9	-0.5	-0.7	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	3.6	0.9	0.8	0.5	1.4	0.9	0.5	0.1	0.6	-0.0	1.9	1.6	1.9
Leg predicted mass (right)	1.1	6.0	22.5	1.2	-0.2	1.8	1.3	1.8	4.7	3.6	2.5	1.6	3.2	1.9	2.2
Average weekly beer plus cider intake	1.1	1.6	6.6	1.0	0.7	-0.1	2.1	-0.2	-0.4	0.7	-1.0	0.5	2.0	0.9	2.6
Alcohol drinker status: Previous	1.1	1.3	4.1	0.0	0.2	-1.1	2.0	-0.5	-0.6	1.3	-0.5	1.4	1.7	0.1	1.6
Age at First Birth	1.0	1.5	4.2	0.9	1.5	1.2	-0.9	1.4	1.7	0.5	2.0	1.3	-0.4	1.2	-0.2
Frequency of depressed mood in last 2 weeks	1.0	1.3	3.4	-0.7	-1.1	-1.6	0.8	-1.5	-1.5	-0.1	-1.5	-1.9	0.9	0.1	0.3
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.5	-1.0	-0.6	-0.6	1.3	-1.2	-1.6	-1.3	-1.1	0.9	1.1	-0.6	0.8
Average weekly fortified wine intake	1.0	1.2	2.7	1.3	1.1	1.2	-0.5	1.6	1.4	0.8	1.4	0.9	-0.4	1.1	-0.4
Qualifications: A levels/AS levels or equivalent	1.0	2.3	7.3	1.3	1.0	2.6	-1.1	2.1	1.3	-0.1	0.9	2.7	-1.4	0.3	-0.7
Hair/balding pattern: Pattern 4	1.0	2.4	7.5	1.1	0.3	1.0	1.4	1.0	2.7	2.7	0.9	0.1	2.2	0.3	1.8
Ever highly irritable/argumentative for 2 days	1.0	1.2	5.1	0.7	0.9	1.1	0.8	0.8	1.2	0.5	0.9	0.5	0.9	1.4	2.3
Medication: Ibuprofen	1.0	1.1	3.1	1.8	1.3	1.5	1.1	1.4	0.5	0.7	0.5	0.9	0.5	0.7	0.9
Overall health rating	1.0	2.2	6.4	1.2	1.6	0.3	2.2	0.6	0.3	1.8	0.7	-0.7	1.6	1.8	2.5
Whole body fat-free mass	1.0	5.9	22.2	1.2	-0.4	1.2	1.4	1.7	4.7	3.3	2.0	1.9	3.5	1.9	2.4
Whole body water mass	1.0	5.9	21.8	1.1	-0.5	1.1	1.6	1.6	4.7	3.5	2.0	1.7	3.6	1.9	2.5
Financial situation satisfaction	1.0	1.2	6.0	-1.0	-0.9	0.4	-0.6	-0.5	-0.7	0.1	0.3	-2.5	-1.0	-0.8	-2.0
Fractured/broken bones in last 5 years	1.0	1.3	2.6	-1.1	-1.2	-1.5	1.1	-1.6	-1.2	0.5	-1.2	-1.4	0.9	-0.8	0.6
Arm predicted mass (left)	1.0	5.3	18.0	1.3	0.2	1.2	1.5	1.6	4.2	2.9	2.0	1.9	3.2	2.0	2.7
Lupus	0.9	1.4	2.6	0.9	1.6	1.6	-0.4	1.3	1.4	0.3	1.6	1.3	-0.5	1.3	0.4
Neuroticism (2016)	0.9	1.3	4.7	1.5	0.6	0.7	1.7	0.8	0.1	0.4	0.2	0.4	2.2	0.6	2.0
Medication for hormone replacement therapy	0.9	1.0	2.9	1.1	1.1	1.7	1.3	0.8	0.5	0.2	0.4	-0.7	0.7	1.1	1.1
Leg fat-free mass (left)	0.9	4.6	16.9	1.0	-0.3	1.1	1.3	1.5	4.1	3.1	1.9	1.7	3.0	1.6	2.2
Hand grip strength (right)	0.9	2.4	7.1	0.3	0.8	2.0	-1.0	1.2	2.7	1.0	2.5	2.6	-0.2	0.5	0.0
Supplements: Glucosamine	0.9	1.2	3.3	0.5	0.4	-0.2	1.2	0.9	1.8	1.1	1.2	-0.3	1.6	0.7	1.5
Leg predicted mass (left)	0.9	4.8	17.2	1.1	-0.3	1.1	1.4	1.5	4.2	3.1	1.9	1.7	3.0	1.6	2.3
Number of incorrect matches in round	0.9	1.5	3.2	-1.2	-1.7	-1.2	-0.6	-1.3	-1.5	-0.9	-0.6	-1.8	-0.5	-1.1	-1.4
Pain all over the body in last month	0.9	1.0	5.2	-0.6	-0.3	-0.3	1.2	-0.4	0.5	2.3	0.3	1.1	1.3	-0.6	0.9
Trunk fat-free mass	0.9	5.0	19.7	1.1	-0.6	1.0	1.3	1.5	4.4	3.0	1.8	1.7	3.4	1.8	2.1
Trunk predicted mass	0.9	5.2	20.4	1.2	-0.5	1.0	1.3	1.6	4.5	3.0	1.8	1.7	3.4	1.9	2.2
Peak expiratory flow (PEF)	0.9	2.0	6.7	1.2	1.2	2.0	-0.7	1.7	1.8	1.0	1.2	2.6	-0.7	1.0	-0.5
Worry too long after embarrassment	0.9	1.5	4.5	0.6	2.1	1.4	-1.2	1.1	0.9	-0.7	1.2	1.0	-1.1	1.6	0.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.4	1.4	1.1	1.3	-0.3	1.1	1.5	-0.3	0.5	1.1	-0.6	1.0	0.7
Knee pain experienced in last month	0.9	1.4	4.9	1.3	1.3	1.1	1.2	1.1	0.8	0.7	0.6	2.2	1.5	-0.1	1.1
Diabetes diagnosed by doctor	0.9	1.4	4.8	-0.8	-0.9	-1.6	0.8	-1.4	-2.2	-0.4	-2.0	-1.1	-0.2	-0.2	-0.2
Osteoarthritis (self-reported)	0.9	1.1	3.6	0.8	1.5	0.4	1.3	0.9	0.2	0.3	0.2	1.3	0.6	1.4	1.9
Smoking status: Current	0.9	1.4	3.4	-1.1	-1.8	-1.0	0.5	-1.4	-1.4	0.6	-1.1	-1.2	0.8	-1.6	-0.8
Eye problems/disorders: Glaucoma	0.9	1.0	3.1	-1.0	-1.8	-1.4	-0.1	-1.3	-0.5	-0.4	-1.4	-0.6	0.8	-1.1	-0.2
Arm fat-free mass (left)	0.9	4.7	16.5	1.1	0.2	1.2	1.4	1.5	4.1	2.6	2.0	1.9	3.0	1.9	2.4
Irritability	0.9	1.6	2.9	1.7	1.1	1.0	0.7	1.4	1.6	1.5	1.3	-0.2	0.8	1.3	1.7
Age started oral contraceptive pill	0.9	1.2	4.4	-1.5	-1.4	-0.4	-0.9	-1.3	-0.7	-0.7	-0.4	-0.6	-0.7	-2.1	-0.8
Pain experienced in last month	0.9	1.6	6.7	-1.0	-0.7	0.0	-2.4	-0.4	0.1	0.0	0.4	0.1	-2.6	-0.3	-2.2
Worry (Nagel 2018)	0.8	1.6	4.4	1.5	1.8	1.0	-1.0	1.6	1.3	0.4	1.6	0.2	-0.5	2.1	0.8
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.4	1.2	0.6	0.2	0.2	1.3	1.5	1.4	0.7	-0.2	0.1	1.4	0.8
High blood pressure (mother)	0.8	1.1	7.2	-0.4	0.7	-0.3	-0.8	-0.1	-1.7	-2.7	-0.5	0.0	-1.1	0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	3.3	1.6	1.2	1.8	0.4	1.5	0.5	0.2	0.5	1.5	-0.0	0.5	0.1
Prospective memory result	0.8	1.0	2.2	-0.9	-1.2	-0.8	0.4	-1.5	-0.2	0.3	-1.0	-1.2	1.1	-1.5	-0.7
Medication: Paracetamol	0.8	1.4	3.7	1.9	1.3	0.1	1.9	1.3	0.1	0.9	-0.2	0.3	1.1	0.8	1.7
Glaucoma (self-reported)	0.8	0.9	2.2	-0.5	-1.5	-1.5	0.1	-1.0	-0.4	-0.8	-1.3	-0.8	1.3	-0.6	-0.1
Arm fat-free mass (right)	0.8	4.2	15.3	0.7	-0.4	1.1	1.3	1.3	3.9	2.9	1.9	1.4	3.0	1.6	2.0
Age at first live birth	0.8	1.4	4.1	-0.2	0.3	1.9	-1.6	0.8	0.7	-0.4	1.6	0.1	-2.0	-0.3	-1.6
Pulse wave peak to peak time	0.8	0.9	5.0	0.3	-0.2	0.7	-1.4	0.6	-0.1	-0.5	-0.5	-1.1	-0.8	-0.6	-2.2
Arm predicted mass (right)	0.8	3.9	15.8	0.7	-0.5	1.1	1.1	1.2	4.0	2.8	1.9	1.4	2.8	1.5	1.9
Pulse rate, automated reading	0.8	2.4	6.3	-1.6	-2.4	-1.8	1.2	-1.9	-0.3	0.6	-1.4	-1.1	2.5	-1.3	0.9
Illnesses of siblings: Diabetes	0.8	1.0	3.1	0.7	0.0	-0.2	1.8	0.7	-0.2	1.2	-0.3	-1.7	1.2	0.9	1.0
Osteoporosis (self-reported)	0.8	1.0	3.9	0.3	0.4	-0.0	-1.3	0.6	-0.3	-2.0	0.7	-0.6	-1.4	1.0	-1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	3.8	-0.4	-0.7	0.9	-2.0	-0.4	0.0	-1.3	0.2	-1.3	-1.4	-0.2	-1.2
Medication: Atorvastatin	0.8	1.0	3.4	-1.1	-0.9	-0.9	-1.1	-0.8	-1.0	-0.9	-0.6	-0.1	-1.8	-0.6	-1.1
Basal metabolic rate	0.8	4.5	16.3	1.1	-0.0	1.1	1.2	1.5	4.0	2.8	1.9	1.9	2.8	1.9	2.2
Irritable Bowel Disease (IBD)	0.7	1.7	4.7	2.2	1.1	1.3	1.0	1.5	1.4	1.4	0.3	1.0	1.0	1.6	0.9
Bipolar Disorder (2011)	0.7	0.7	2.7	0.1	0.9	0.4	-1.0	0.5	0.8	0.4	1.2	0.9	-1.6	0.2	-0.3
Fasting Glucose	0.7	0.8	3.6	-0.7	-1.0	-1.5	-0.5	-1.9	-0.0	-0.7	-0.8	-0.2	0.1	-0.9	0.3
Primary Biliary Cirrhosis	0.7	1.0	2.8	1.3	1.2	0.8	-0.5	1.5	0.9	0.2	0.3	1.2	-0.3	1.7	0.2
Blood White Count	0.7	5.5	22.3	-1.3	-0.1	-1.1	-1.2	-0.9	-4.7	-3.5	-1.0	-2.7	-3.1	-1.2	-2.6
Trunk fat percentage	0.7	2.8	10.0	-1.1	1.1	-0.8	-1.4	-1.2	-3.2	-2.3	-1.0	1.2	-2.8	-0.6	-0.8
Relative age voice broke	0.7	1.1	3.2	-1.8	-1.1	-1.0	0.4	-1.3	-1.4	-0.8	-0.0	0.1	-0.1	-1.6	-0.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.3	0.3	0.6	0.8	-1.5	0.1	1.3	-0.6	0.7	1.3	-1.3	0.6	-0.5
High blood pressure	0.7	2.0	8.1	-0.3	1.6	-0.6	-0.9	-0.6	-2.9	-2.2	-1.1	0.7	-1.8	-0.7	-1.1
Had other major operations	0.7	0.9	2.0	1.0	0.7	1.2	-0.0	1.2	1.4	1.1	1.1	1.0	0.1	0.6	0.9
Qualifications: None of the above	0.7	1.4	5.9	-1.3	-0.9	-1.5	1.0	-1.6	-0.2	0.5	0.1	-2.4	1.5	-0.0	0.7
Heart attack	0.7	0.9	2.9	0.4	0.8	0.0	0.2	0.8	1.7	1.1	1.0	0.3	0.1	1.3	1.4
Happiness	0.7	0.9	3.1	0.6	1.2	1.0	-0.2	0.7	0.4	1.3	1.3	-0.4	-0.8	1.8	0.2
Pulse wave Arterial Stiffness index	0.7	0.8	4.2	-0.6	-0.0	-0.8	1.3	-0.7	-0.1	0.5	0.5	1.2	0.6	0.4	2.0
Pulse wave reflection index	0.7	0.8	5.4	-0.6	0.1	-0.2	-1.3	-0.2	-0.2	-0.6	1.0	-0.0	-2.3	0.5	-1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.2	1.0	-0.1	1.1	0.4	1.4	1.8	0.8	1.5	-1.0	0.8	1.2	1.1
Body fat percentage	0.7	2.6	10.7	-0.9	1.1	-1.1	-1.1	-1.1	-3.3	-2.3	-1.2	1.0	-2.5	-0.5	-0.5
Leg fat percentage (right)	0.7	2.4	10.2	-0.2	1.5	-1.5	-0.5	-0.9	-3.2	-2.5	-1.6	1.1	-1.8	-0.2	0.2
Age at last live birth	0.7	0.9	4.4	0.8	0.9	2.1	-0.6	1.1	0.8	0.5	1.2	-0.2	-0.8	1.0	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.3	-0.9	-0.6	-0.5	-0.9	-0.8	-1.1	-0.6	-0.2	-1.4	-1.5	-0.1	-1.4
Hypertension (Self-reported)	0.7	2.1	7.1	-0.5	1.6	-0.5	-1.2	-0.7	-2.7	-2.2	-0.7	1.0	-2.0	-0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.7	-1.7	-1.5	-0.9	-1.1	-1.9	-1.1	-0.1	-0.9	0.9	-0.7	-1.1	-1.6
Average weekly red wine intake	0.7	1.1	3.3	-0.5	0.4	1.0	-1.7	0.1	0.5	-0.5	1.2	0.0	-1.7	-0.7	-1.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.2	-0.6	-0.5	-1.0	1.3	-0.6	-0.1	1.0	-0.2	-0.7	1.4	0.2	1.5
Alzheimer’s Disease (in father)	0.6	0.7	1.9	-0.9	-1.2	-1.0	0.3	-1.1	0.1	0.7	-0.4	-1.0	1.4	-0.5	0.0
LDL Cholesterol	0.6	0.9	3.1	0.3	0.4	0.5	-1.7	0.4	0.3	0.0	1.0	1.1	-1.7	0.2	-1.5
Fed-up feelings	0.6	1.1	2.6	1.0	0.9	0.6	1.3	0.7	0.8	1.6	0.8	0.4	0.7	1.5	1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.2	0.3	0.3	-0.5	1.5	0.1	-0.6	-0.2	-0.7	-0.4	1.1	0.8	1.5
Had menopause	0.6	0.8	1.3	-1.1	-0.6	-1.0	-1.0	-1.1	-1.0	-1.1	-0.1	-0.9	-0.8	-0.1	-0.7
Medication: Ramipril	0.6	0.8	3.1	0.3	1.1	1.1	-0.9	0.5	-0.5	-1.1	0.0	0.8	-1.8	0.8	-0.4
Illnesses of siblings	0.6	0.9	2.7	0.2	0.1	0.9	-1.6	0.5	1.0	-1.1	0.9	0.7	-1.5	0.4	-1.0
Neuroticism score	0.6	1.2	2.9	1.2	1.5	1.0	0.2	1.1	1.0	0.8	1.2	0.4	0.3	1.7	1.3
Worrier / anxious feelings	0.6	1.1	2.4	1.0	1.5	0.9	-0.5	1.2	0.6	-0.4	0.8	1.5	-0.8	1.5	1.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	4.8	0.0	0.8	-0.2	0.1	0.3	-0.2	1.4	0.1	2.2	-0.7	1.1	-0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.1	0.3	0.7	1.8	-0.6	0.5	1.8	1.0	1.3	1.4	0.2	0.6	0.5
Comparative body size at age 10	0.6	1.7	8.2	0.7	-0.3	-1.6	1.5	-0.0	1.2	1.5	-0.5	-0.2	2.9	0.3	1.8
Wheeze or whistling in the chest in last year	0.6	1.1	2.5	1.4	0.2	0.2	1.2	0.6	0.9	0.9	-0.3	-0.6	1.6	1.4	1.6
Eye problems/disorders: None of the above	0.6	0.7	1.1	0.6	0.7	1.1	-1.0	0.9	1.1	1.0	1.0	0.6	-0.9	0.1	-0.8
Medication: Blood pressure	0.6	1.1	3.6	0.1	1.3	-0.1	0.3	-0.4	-1.9	-1.1	-1.7	1.8	-0.5	-0.4	-0.5
Loneliness, isolation	0.6	0.8	3.0	-0.4	-0.5	-0.8	0.2	-1.4	-1.7	-0.9	-1.5	-0.8	0.1	-0.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.7	0.5	0.6	-0.4	1.7	-0.0	-0.3	0.0	-0.4	1.0	1.4	0.3	1.9
Back pain experienced in last month	0.6	0.9	5.2	0.6	-0.2	-0.8	0.9	0.0	-0.2	-0.7	-0.7	-2.3	1.2	0.2	1.1
Asthma (self-reported)	0.6	1.1	3.4	1.2	0.6	0.5	0.9	1.0	1.5	0.7	0.8	-0.2	1.8	1.2	1.2
Guilty feelings	0.6	1.0	3.4	0.7	0.9	0.6	1.1	0.3	0.0	0.9	0.0	1.3	0.5	1.6	1.8
Commuting to job workplace: Public transport	0.6	0.7	1.6	0.8	0.7	1.3	0.5	1.0	0.7	0.5	0.7	0.1	1.0	0.7	1.2
Illnesses of father: High blood pressure	0.6	0.7	2.9	-1.1	-0.1	-1.7	0.2	-0.8	-1.0	-0.2	-0.6	1.0	-0.2	-1.1	-0.3
Ever smoked	0.6	1.1	3.5	-0.7	-0.4	0.5	-1.7	-0.3	-0.2	-1.2	0.4	0.4	-1.9	-1.2	-1.6
Number of operations (self-reported)	0.6	0.8	2.8	0.5	0.4	0.7	-0.0	0.8	1.7	0.7	1.5	0.7	0.6	1.1	1.1
Unable to work because of sickness or disability	0.6	0.8	2.3	0.6	0.8	-0.1	1.5	0.4	-0.1	1.3	-0.0	1.0	1.3	0.5	1.5
Myopia	0.6	0.8	4.5	-0.2	0.2	0.0	-2.1	0.1	0.7	0.0	0.9	-0.3	-1.4	0.1	-1.4
Vascular/heart problems diagnosed by doctor	0.6	1.6	5.1	0.3	-1.3	0.5	1.1	0.7	2.3	2.1	1.1	-0.4	1.8	0.6	1.0
Crohns Disease (2017)	0.5	1.2	3.4	1.5	0.5	0.2	1.9	0.5	0.3	1.2	-1.0	0.4	1.8	0.3	1.2
Blood Platelet Count	0.5	6.1	23.1	-2.5	-1.7	-1.1	-0.6	-2.2	-4.8	-3.6	-2.1	-2.0	-1.2	-2.6	-2.3
Heel T-Score	0.5	3.8	9.2	2.3	1.4	-0.3	2.6	1.1	2.1	2.5	0.1	1.5	2.5	1.3	3.0
Height	0.5	9.8	18.7	-4.2	-3.0	-1.3	-3.5	-2.7	-2.3	-3.4	-1.9	3.6	-3.0	-2.9	-4.3
Smoking Status	0.5	1.1	2.3	-1.2	-1.4	-1.5	0.6	-1.3	-1.3	0.7	-0.5	-0.8	0.2	-1.3	-0.7
Hearing difficulty/problems: Yes	0.5	0.8	3.1	0.5	0.1	-0.1	1.8	-0.1	-0.7	0.1	-1.0	-0.9	1.0	0.1	1.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.3	0.6	1.1	1.1	0.5	0.7	0.8	-0.1	0.6	0.6	0.9	0.5	1.2
Severe depression (siblings)	0.5	0.5	1.7	1.0	0.9	0.3	0.7	0.9	-0.0	0.8	0.3	-0.1	-0.0	1.3	0.6
Age when periods started (menarche)	0.5	1.2	3.6	-0.9	-1.6	-0.1	-0.9	-0.7	-0.7	-0.7	-1.2	-0.5	-1.2	-1.2	-1.9
Serious illness, injury or assault to yourself	0.5	0.6	2.4	-1.2	-0.9	-0.7	0.2	-0.9	-0.6	-0.0	0.0	-1.5	0.3	-0.7	-0.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	4.0	0.5	0.3	2.0	-1.3	1.5	1.2	-0.7	0.6	-0.2	-1.4	1.0	-0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.7	-1.2	-0.7	-0.2	-0.3	-0.8	-0.9	-0.7	-0.1	-1.6	-0.5	0.3	-0.6
Fluid intelligence score	0.5	1.1	9.4	0.8	0.7	0.9	-0.6	1.0	0.3	-0.5	-0.1	3.1	-0.4	-0.1	-0.1
Pulse rate	0.5	0.8	3.1	-0.5	-1.2	-0.5	1.0	-0.6	0.3	0.4	-0.1	-0.6	1.8	-0.8	1.3
Medication: Lansoprazole	0.5	0.6	2.6	-0.8	-0.7	-0.8	0.7	-1.1	-0.6	-0.3	-0.7	0.3	0.4	-0.2	1.6
Arm fat mass (right)	0.5	2.0	5.1	1.5	1.9	0.8	0.8	1.3	1.1	0.9	0.9	1.9	0.6	1.9	2.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	0.9	0.1	0.2	0.6	1.0	1.1	0.6	0.6	-0.9	0.7	0.5	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.2	-0.0	-0.3	-0.3	1.3	-0.4	-0.1	0.4	-0.3	-1.5	1.2	0.6	0.8
Chest pain or discomfort	0.5	0.8	2.4	0.5	0.9	0.9	-0.4	0.6	1.0	1.6	1.0	0.3	-0.4	1.4	0.4
Supplements: Vitamin C	0.5	0.6	3.2	-0.2	-0.8	-1.8	-0.0	-0.5	0.3	0.0	-0.5	-0.3	1.4	-0.2	0.0
Smoking status: Previous	0.5	0.7	4.0	-0.8	0.2	-0.1	-1.3	-0.4	-0.1	-0.5	0.8	0.3	-2.0	-0.3	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	-0.4	-0.2	-0.2	-0.2	-0.5	-1.4	-1.1	-1.0	1.4	-0.5	-0.4	-0.3
Mood swings	0.5	0.9	3.5	0.6	1.3	1.3	-0.4	0.9	0.5	0.4	1.9	0.1	-1.0	1.1	-0.0
Qualifications: nursing, teaching	0.5	0.7	2.5	0.6	-0.0	1.6	-1.3	0.8	0.7	-0.5	0.1	1.1	-1.2	-0.3	-0.4
Medication for cholesterol	0.5	0.7	1.9	0.0	-0.6	0.5	0.8	0.2	1.0	1.3	0.2	1.4	1.2	-1.0	0.6
Hearing aid user	0.5	0.5	3.2	-0.1	-0.4	0.3	1.1	-0.1	-0.1	1.8	-0.1	-0.5	1.1	-0.4	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.6	0.8	0.3	-0.0	1.4	0.1	0.0	0.1	-1.1	-0.3	1.6	0.3	1.1
Leg fat percentage (left)	0.5	1.7	6.7	0.2	1.8	-0.7	-0.4	-0.3	-2.6	-1.9	-1.0	1.2	-1.8	0.1	0.2
Commuting to job workplace: Cycle	0.5	0.6	2.1	1.1	0.6	0.5	0.7	0.8	0.6	1.4	0.6	-0.2	0.4	0.7	0.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.7	1.9	1.2	1.4	0.6	1.7	0.9	0.4	-0.2	1.5	0.9	0.9	1.0
Neuroticism (Nagel 2018)	0.4	0.9	3.2	1.0	1.6	0.4	0.1	0.8	0.6	0.4	1.0	0.3	0.2	1.8	1.4
Schizophrenia (2018)	0.4	0.9	3.6	-0.7	-0.4	-1.3	0.2	-1.0	-1.9	0.1	-0.5	-1.5	-0.2	-0.7	-0.8
Blood Red Count	0.4	3.8	18.2	-1.6	-0.2	-1.7	-2.6	-0.7	-2.1	-4.3	-0.3	-1.7	-2.0	0.7	-1.7
Neuroticism	0.4	0.9	2.6	0.8	1.6	0.7	-0.3	1.0	0.6	0.3	0.9	0.7	0.3	1.6	1.2
Number of treatments/medications taken	0.4	0.8	2.4	1.2	1.5	0.8	0.5	0.9	0.4	0.6	0.4	-0.2	0.1	1.6	1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.3	0.3	-0.1	-0.6	1.0	-0.2	-0.9	-0.3	-1.1	-0.8	0.8	0.7	0.7
Diabetes (mother)	0.4	0.5	1.6	0.7	0.5	-0.4	1.1	0.5	-0.2	1.3	-0.2	1.0	0.5	0.3	0.8
Townsend deprivation index at recruitment	0.4	0.5	2.4	-0.5	-0.0	-0.4	0.2	-0.4	-1.3	-1.6	-0.8	-0.6	-0.3	-0.1	-0.4
Multivitamins +/- minerals	0.4	0.5	1.8	-0.3	0.1	0.3	-1.3	0.1	1.1	-0.3	1.3	0.3	-0.6	0.0	-0.3
Sitting height	0.4	3.0	8.0	-2.2	-1.9	0.1	-2.8	-1.1	0.8	0.8	0.4	2.0	-1.5	-1.7	-2.8
Chronic bronchitis/emphysema (father)	0.4	0.5	1.8	0.0	0.0	0.7	1.2	0.0	0.3	0.4	0.1	0.4	1.4	-0.7	0.8
Financial difficulties in last 2 years	0.4	0.5	2.9	0.7	0.9	0.6	0.6	0.5	-0.2	1.7	0.3	0.6	0.3	0.2	-0.1
Allergy	0.4	1.0	2.6	-1.0	-0.5	-1.6	0.4	-1.5	-1.5	-0.0	-0.6	0.5	0.3	-1.5	-0.5
Diabetes (self-reported)	0.4	0.6	2.7	-0.1	-0.3	-0.8	1.1	-0.6	-1.6	-0.4	-1.4	-0.8	0.1	0.1	0.1
Time employed in main current job	0.4	0.4	1.7	0.7	0.5	0.9	0.2	1.3	0.6	-0.7	0.3	-0.3	-0.6	0.8	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.8	0.2	0.0	-0.3	1.1	-0.3	-1.2	-0.1	-1.3	-0.9	0.6	0.7	0.8
Mouth/teeth dental problems: Dentures	0.4	0.7	2.6	-0.4	-0.5	-0.8	1.0	-0.9	0.2	0.7	-0.4	-0.9	1.1	0.4	1.6
Asthma	0.4	0.8	2.6	1.0	0.6	0.4	0.7	0.9	1.3	0.6	0.7	-0.2	1.6	1.1	1.0
Standing height	0.4	4.3	10.0	-3.0	-2.4	-0.5	-2.7	-1.8	-1.1	-1.9	-0.7	1.8	-2.3	-1.7	-3.2
Tense / ‘highly strung’	0.4	0.6	2.4	0.2	0.7	-0.4	-1.1	0.3	0.3	-0.5	0.8	-1.5	-0.7	1.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.9	0.1	-0.3	0.2	1.3	-0.5	0.2	1.4	-0.1	-0.9	1.3	-0.1	0.3
Birth weight	0.4	0.8	4.4	0.5	-0.7	1.0	0.1	0.6	2.1	0.8	0.1	0.8	1.1	0.5	0.5
Health satisfaction	0.4	0.5	1.5	0.5	-0.1	-0.4	1.2	0.3	-0.2	0.8	-0.5	-1.0	0.8	0.5	1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	-0.1	-0.2	0.5	-1.2	0.0	-0.3	-0.1	-0.8	-0.8	-1.3	-0.4	-1.2
Mean time to correctly identify matches	0.4	0.7	2.5	-1.6	-0.4	0.1	-0.7	-1.1	-0.5	-0.5	0.5	-1.3	-0.7	-0.6	-0.6
Number of full sisters	0.4	0.4	2.5	-0.9	-0.8	-0.9	-0.2	-0.7	-0.2	-0.2	0.2	-1.6	-0.4	-0.2	-0.2
Family relationship satisfaction	0.4	0.5	2.5	-0.4	-0.5	-0.6	0.3	-0.2	-0.3	1.6	-0.1	-1.3	0.1	-0.1	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	2.1	-0.9	-0.4	0.2	-0.8	-0.3	0.2	-0.6	1.4	-0.8	-0.6	-0.2	0.1
Mineral and other dietary supplements	0.4	0.5	1.7	-0.6	-0.6	0.2	0.2	-1.3	-0.8	0.6	-1.0	0.3	-0.1	-1.0	0.2
Medication: Aspirin	0.4	0.5	1.5	-0.4	-0.3	-1.2	0.5	-0.7	-0.4	1.1	-0.7	-0.9	0.4	0.1	0.7
Arm fat mass (left)	0.4	1.6	4.4	1.2	1.7	0.6	0.7	1.2	0.9	0.7	0.7	1.8	0.6	1.7	2.1
Miserableness	0.4	0.8	2.5	0.5	0.9	1.0	1.6	0.3	-0.4	1.4	0.2	-0.1	0.8	1.2	0.7
Ever taken oral contraceptive pill	0.4	0.4	1.1	-0.3	-1.0	-1.0	1.0	-0.3	-0.3	-0.1	-1.0	0.9	0.3	-0.1	0.6
Ever depressed for a whole week	0.4	0.5	1.4	-0.2	0.1	0.5	1.1	-0.2	0.1	0.7	0.4	-1.2	0.8	0.7	1.0
Supplements: Calcium	0.4	0.5	2.5	0.7	0.2	0.0	0.8	0.6	0.2	0.3	0.6	-1.6	0.9	0.6	0.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	-0.3	-0.6	-1.0	0.3	-0.7	-1.1	-0.4	-0.9	-0.8	0.1	-0.9	0.0
Heart attack/myocardial infarction (self-reported)	0.4	0.6	2.0	0.0	0.6	-0.1	0.1	0.5	1.4	0.9	0.9	0.3	0.1	1.1	1.1
Bipolar Disorder or Schizophrenia	0.3	0.7	3.1	-0.8	0.2	-1.2	0.1	-1.0	-1.8	-0.1	-0.1	-0.9	-0.6	-0.7	-0.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.8	0.5	1.0	0.1	0.8	0.3	0.1	0.5	0.8	0.0	0.7	1.2	1.3
Ovarian Cancer	0.3	0.3	0.9	-0.6	-0.3	-0.2	-0.9	-0.6	-0.4	-0.7	-0.1	-0.1	-1.0	-0.7	-0.8
Schizophrenia (2014)	0.3	0.6	3.0	-0.8	-0.1	-1.1	0.3	-0.9	-1.7	0.3	-0.2	-1.0	-0.1	-0.5	-0.5
Blood Eosinophil Count	0.3	2.0	7.8	0.4	0.6	0.7	-2.6	0.9	-0.3	-1.9	0.8	-0.6	-2.8	-0.1	-1.8
Angina	0.3	0.4	2.3	0.1	0.2	-0.1	0.2	0.3	0.8	0.2	0.4	0.6	0.4	1.5	1.2
Supplements: Zinc	0.3	0.3	1.0	0.4	0.8	0.3	-1.0	0.4	0.7	-0.9	0.5	-0.5	-0.1	-0.3	0.1
Waist circumference	0.3	0.9	4.0	0.6	1.0	-0.7	1.2	0.1	-0.3	0.2	-0.3	0.2	1.0	1.6	2.0
Past tobacco smoking	0.3	0.5	2.5	0.5	-0.1	-0.3	1.0	0.1	0.1	-0.0	-0.7	-0.7	1.6	0.5	0.8
Alcohol usually taken with meals	0.3	0.6	1.8	0.3	-0.1	0.8	-0.8	1.0	0.7	0.3	1.0	-0.4	-0.8	0.3	-1.3
Nervous feelings	0.3	0.5	2.7	-0.2	-0.1	-0.4	-1.3	0.0	0.0	-0.7	0.2	-1.6	-0.7	0.6	-0.5
Hearing difficulty/problems with background noise	0.3	0.5	1.9	0.0	-0.1	-0.6	0.3	-0.2	-1.1	-0.8	-1.0	-1.4	-0.3	0.0	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.2	0.0	-0.3	-1.5	1.3	-0.5	-0.5	0.8	-1.0	0.6	1.1	-1.2	0.5
Mouth/teeth dental problems	0.3	0.5	1.3	0.8	0.4	1.2	-0.8	1.0	0.5	-0.7	0.7	-0.3	-0.5	-0.5	-0.7
Weight	0.3	1.6	3.7	0.7	0.9	0.5	0.6	1.0	1.7	1.2	1.1	1.9	1.1	1.7	1.8
Illnesses of mother	0.3	0.4	1.6	-0.3	-0.7	-0.5	0.5	-0.7	0.8	1.3	0.2	-0.6	0.6	-0.1	0.7
Blood clot in the leg (DVT)	0.3	0.4	1.5	-0.4	-0.7	-0.0	-0.3	-0.5	1.2	0.6	0.6	0.5	-0.4	-1.0	0.5
Angina (self-reported)	0.3	0.5	2.1	0.3	0.3	-0.0	0.2	0.4	0.8	0.4	0.5	0.7	0.4	1.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	-0.2	-0.3	-0.2	-1.1	-0.0	-0.4	-0.7	-0.3	-0.8	-0.8	-0.2	-1.2
Comparative height size at age 10	0.3	1.6	6.2	-1.1	-0.0	0.1	-2.5	0.0	1.0	-0.7	1.0	1.4	-1.8	0.1	-1.8
Had major operations	0.3	0.3	1.5	-0.4	0.1	0.2	-0.4	0.0	0.9	0.8	1.2	-0.1	-0.2	0.7	0.1
Medication: Aspirin	0.3	0.4	1.2	-0.8	-0.5	-1.1	-0.2	-0.9	-0.6	0.5	-0.6	-0.8	-0.3	-0.0	-0.1
Long-standing illness, disability or infirmity	0.3	0.5	2.3	-0.4	0.0	-0.2	1.5	-0.5	-0.9	0.3	-0.5	-0.6	1.2	0.3	0.8
Ever had bowel cancer screening	0.3	0.4	1.5	-1.0	0.0	-1.1	-0.3	-0.9	0.0	0.1	0.1	-0.5	-0.1	-0.4	1.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	0.3	-0.0	-0.5	-0.8	0.7	0.1	-1.1	0.2	-0.5	-1.0	0.7	-0.9
High cholesterol (Self-reported)	0.3	0.6	1.7	0.1	0.6	-0.6	-1.0	0.1	-0.6	-1.3	-0.6	-0.1	-1.3	0.6	-0.8
Cholesterol lowering medication	0.3	0.4	2.3	0.7	0.4	-0.6	0.0	0.4	0.3	0.5	0.3	-0.7	-0.0	1.5	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.3	-0.4	-0.6	0.0	-0.1	-0.5	1.2	0.4	0.7	0.5	-0.2	-0.7	0.7
Major Depression (MDD)	0.2	0.2	0.9	1.0	0.2	0.1	0.0	0.5	0.4	0.4	-0.3	-0.5	0.4	0.5	-0.0
Reaction Time	0.2	0.4	1.7	-1.3	0.1	0.6	-0.6	-0.8	-0.6	-0.6	0.4	-0.5	-0.4	-0.4	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.7	0.6	0.1	0.9	-0.6	0.9	-0.1	-0.2	-0.5	1.7	-0.7	-0.4	-0.9
Crohns Disease (2012)	0.2	0.3	1.5	0.2	-0.1	-0.5	0.5	-0.3	-0.3	0.3	-1.2	0.1	0.7	-1.0	0.1
HDL Cholesterol	0.2	0.4	1.3	-1.1	-0.8	-0.1	-0.3	-0.8	-0.8	-0.3	-0.5	-0.3	-0.2	-1.0	-0.7
Rheumatoid Arthritis	0.2	0.2	0.6	0.4	-0.1	-0.3	0.1	0.2	0.4	0.7	-0.8	0.6	0.7	-0.4	-0.0
Allergy or Eczema	0.2	0.6	1.7	0.1	-0.2	1.3	-1.1	0.8	0.8	-1.1	0.1	-0.6	-0.8	0.3	-0.6
Respiratory disease	0.2	0.4	2.1	0.0	-0.2	0.4	0.1	0.3	1.3	-0.1	0.4	-0.5	1.5	0.3	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.9	0.1	-0.1	-0.9	0.4	-0.7	-1.1	-0.1	-1.4	-0.5	0.0	0.6	0.3
Chronotype (morning person)	0.2	0.6	2.7	-0.0	-0.3	-0.1	0.8	-0.2	0.0	-0.6	-1.0	-0.6	1.7	0.5	1.2
Ever had hysterectomy (womb removed)	0.2	0.3	1.5	0.4	0.4	-0.2	0.2	0.2	0.0	-0.8	0.0	-1.2	0.5	0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	2.1	0.4	0.1	-1.0	1.0	-0.2	0.3	0.4	-0.5	0.6	1.5	-0.7	1.1
Medication: Levothyroxine sodium	0.2	0.4	1.2	-0.7	-0.3	0.4	-0.9	-0.7	0.7	0.4	0.7	1.1	-0.3	0.2	0.1
Trunk fat mass	0.2	1.0	2.8	-0.6	0.9	-0.4	-0.9	-0.5	-1.7	-1.3	-0.4	1.6	-1.7	0.1	-0.0
Medication: Simvastatin	0.2	0.2	0.6	0.1	0.3	-0.8	-0.2	-0.1	-0.4	-0.4	-0.7	-0.7	-0.5	0.6	0.2
Arm fat percentage (right)	0.2	0.8	2.8	0.9	1.7	-0.2	0.4	0.4	-1.0	-0.3	-0.3	1.3	-0.4	1.0	1.4
Alcohol intake versus 10 years previously	0.2	0.3	0.5	0.3	-0.1	-0.3	0.6	-0.5	0.4	-0.6	-0.3	-0.7	0.7	0.6	0.7
Noisy workplace	0.2	0.2	1.1	-0.3	0.0	-0.4	0.4	-0.4	0.7	1.1	-0.1	-0.1	0.6	0.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.8	0.4	0.6	0.3	0.7	0.4	0.3	0.1	0.4	0.6	0.6	0.3
Medication: Cholesterol lowering	0.2	0.3	1.4	-0.3	-0.2	-1.0	0.1	-0.6	-0.4	0.0	-1.2	-0.1	-0.3	-0.5	-0.3
Lung cancer (father)	0.2	0.3	1.3	-0.2	0.3	0.6	-0.3	-0.2	0.5	0.7	1.2	0.5	-0.6	-0.1	0.4
Breastfed as a baby	0.2	0.3	0.7	-0.0	-0.2	0.7	-0.2	0.1	0.5	0.6	0.3	0.5	-0.8	-0.9	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.9	0.6	-0.2	-0.7	0.4	0.3	0.1	-0.7	-0.7	-0.0	1.0	-0.2	0.4
High blood pressure (siblings)	0.2	0.3	1.0	0.1	1.0	0.1	0.7	0.2	-0.6	0.2	-0.2	0.7	0.7	-0.7	0.4
Neck or shoulder pain in last month	0.2	0.3	1.5	-0.0	-0.1	-0.7	0.9	-0.2	-0.3	-0.4	-0.3	-0.2	1.2	-0.2	1.0
Medication: Allopurinol	0.2	0.3	0.6	-0.4	-0.4	-0.6	0.6	-0.4	-0.7	0.8	-0.3	0.2	-0.2	-0.6	-0.5
Leg fat mass (right)	0.2	0.6	2.1	0.2	1.2	-0.5	-0.0	0.0	-1.0	-0.8	-0.3	1.5	-0.6	0.6	0.8
Alcohol intake frequency.	0.2	0.6	3.1	-0.1	0.6	-0.9	0.5	-0.4	0.3	-0.7	0.3	-0.0	0.5	1.0	1.8
Leg pain on walking	0.2	0.3	0.8	-0.3	-0.4	0.0	0.8	-0.0	0.1	0.9	-0.1	-0.9	0.5	-0.1	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.8	0.6	0.4	0.1	0.0	0.5	0.3	-0.1	0.0	-0.1	-0.4	0.9	0.6
Medication: Gliclazide	0.2	0.2	1.1	0.3	-0.0	-1.1	0.0	-0.0	-0.6	-0.3	-0.5	-0.5	0.0	0.4	-0.0
Number of self-reported non-cancer illnesses	0.2	0.4	1.2	0.6	0.9	0.1	0.4	0.2	-0.9	-0.5	-0.3	0.3	0.1	1.1	0.9
Mother’s age at death	0.2	0.2	0.7	-0.4	-0.8	0.2	0.6	-0.5	0.0	-0.1	-0.3	-0.4	0.8	-0.5	0.3
Medication: Lisinopril	0.2	0.2	1.5	0.2	0.7	0.1	0.3	0.1	-0.1	-0.1	-0.0	1.2	0.6	-0.3	0.1
Heart disease (siblings)	0.2	0.3	0.7	0.5	0.5	0.1	0.0	0.3	0.6	0.9	0.6	0.3	0.2	0.8	0.8
Bipolar Disorder (2018)	0.1	0.2	0.7	-0.3	0.9	-0.2	-0.1	-0.3	-0.4	-0.3	0.5	0.4	-0.8	-0.1	0.1
Tanning	0.1	1.1	5.1	0.5	0.5	1.0	0.4	0.5	1.1	1.8	1.0	2.3	0.2	0.1	0.6
Sensitivity / hurt feelings	0.1	0.2	0.5	0.4	0.4	-0.1	-0.2	-0.1	0.6	-0.2	0.1	0.7	0.6	0.4	0.5
Vitamin and mineral supplements	0.1	0.1	0.5	0.0	0.3	0.5	0.3	-0.1	-0.7	0.0	-0.4	0.2	-0.5	-0.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	-0.3	0.1	0.3	-0.2	-0.5	-0.5	-0.7	0.2	-0.6	-0.5	0.1	-0.1
Taking other prescription medications	0.1	0.2	0.4	0.1	0.1	0.7	0.3	0.2	0.2	-0.6	0.3	-0.6	0.2	0.3	0.6
Gout (self-reported)	0.1	0.1	0.3	-0.1	0.3	0.3	0.4	0.1	-0.5	0.5	0.1	0.5	-0.4	0.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.6	-0.3	0.4	-0.1	-0.4	-0.1	-0.1	-0.4	0.4	0.8	-0.1	0.2	0.1
Whole body fat mass	0.1	0.6	2.4	-0.2	1.0	-0.4	-0.3	-0.3	-1.2	-0.8	-0.3	1.5	-1.0	0.4	0.5
Arm fat percentage (left)	0.1	0.6	1.8	0.4	1.3	-0.3	0.2	0.1	-1.3	-0.5	-0.4	1.0	-0.5	0.6	1.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.2	-0.2	0.3	0.6	-0.0	-0.2	0.0	0.1	-0.2	0.3	-0.4	0.2
Risk taking	0.1	0.2	0.7	0.0	0.1	-0.9	-0.1	-0.6	0.6	-0.3	0.4	0.6	-0.1	-0.0	0.4
Leg fat mass (left)	0.1	0.6	2.3	0.5	1.4	-0.1	0.1	0.3	-0.6	-0.5	-0.0	1.5	-0.4	0.7	0.9
Hair Pigment	0.0	0.2	0.8	-0.1	-0.4	-0.9	-0.0	-0.3	-0.1	0.5	0.1	-0.8	-0.0	0.4	-0.2

Hub : Genes

PLCE1

Models

Trait associations