TWAS hub - FFAR4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0536	0.0252	1.9e-02	0.020	0.003	0.017	0.017	0.022	0.00047	0.12000	1.2e-03	1.1e-03	2.4e-04
2	ROSMAP	Brain Pre-frontal Cortex	0.1119	0.0307	2.5e-05	0.029	0.033	0.040	0.038	0.041	0.00011	0.00004	6.7e-06	1.2e-05	4.3e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Waist Hip Ratio (WHR)	9.7	43.7	53.3	5.8	7.3
Prospective memory result	8.8	10.8	11.9	-3.4	-3.1
Ovarian Cancer	8.0	10.6	15.7	-4.0	-2.4
Breast Cancer	5.9	14.2	19.6	-4.4	-3.0
Neuroticism (2016)	4.6	6.6	9.3	-3.0	-2.0
HDL Cholesterol	4.5	7.5	8.0	-2.7	-2.8
Triglycerides	4.1	6.7	7.6	2.4	2.8
Hayfever/allergic rhinitis (self-reported)	3.9	5.1	7.3	2.7	1.7
Guilty feelings	3.9	5.9	7.1	-2.7	-2.2
Medication: Aspirin	3.8	5.0	7.2	1.7	2.7
Medication: Atorvastatin	3.8	4.7	4.8	2.2	2.1
Chronic bronchitis/emphysema (mother)	3.7	4.4	4.5	-2.1	-2.1
Hearing difficulty/problems: Yes	3.6	5.5	8.8	3.0	1.5
Medication: Ventolin 100micrograms inhaler	3.6	4.6	7.2	-1.4	-2.7
Worrier / anxious feelings	3.5	6.7	7.3	-2.7	-2.5
Glaucoma (self-reported)	3.5	4.2	5.4	1.7	2.3
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.6	7.7	-1.9	-2.8
Medication: Aspirin	3.3	4.3	6.2	1.6	2.5
Had major operations	3.1	3.6	4.4	2.1	1.7
Eye problems/disorders: Glaucoma	3.0	3.6	4.2	1.7	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.8	8.0	-1.9	-2.8
Neuroticism	2.7	6.5	6.7	-2.6	-2.5
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	3.7	-1.7	-1.9
Hand grip strength (right)	2.6	7.1	9.6	3.1	2.2
Medication: Paracetamol	2.6	4.4	7.0	-1.3	-2.6
Qualifications: nursing, teaching	2.6	4.0	6.4	2.5	1.3
Illnesses of father: None of the above (group 1)	2.6	3.2	4.6	1.4	2.1
Illnesses of father: High blood pressure	2.6	3.3	4.8	-1.3	-2.2
Primary Biliary Cirrhosis	2.5	3.6	5.9	-1.1	-2.4
Pulse rate, automated reading	2.5	8.2	9.3	2.7	3.0
Hair/balding pattern: Pattern 2	2.4	3.0	3.5	1.9	1.6
Time employed in main current job	2.4	2.8	3.3	-1.8	-1.5
Ever taken oral contraceptive pill	2.4	2.7	5.1	-0.5	-2.3
HbA1C	2.3	2.6	3.1	-1.8	-1.4
Angina	2.3	3.0	4.1	2.0	1.4
Had other major operations	2.3	2.8	3.5	-1.5	-1.9
Health satisfaction	2.2	2.9	3.5	-1.9	-1.5
Miserableness	2.2	3.8	4.8	-2.2	-1.7
Cholesterol lowering medication	2.2	3.3	4.6	1.4	2.1
Medication: Omeprazole	2.1	2.5	2.8	-1.7	-1.5
Bipolar Disorder (2011)	2.0	1.9	3.0	-1.7	-1.0
Severe depression (siblings)	2.0	2.2	3.5	-1.0	-1.9
Pain all over the body in last month	2.0	2.1	2.4	1.4	1.5
Fluid intelligence score	2.0	4.1	4.2	2.0	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	2.6	-1.5	-1.6
Neuroticism (Nagel 2018)	1.9	4.4	6.0	-2.4	-1.7
Blood White Count	1.9	13.9	23.0	2.2	4.8
Impedance of arm (right)	1.9	9.0	10.2	-3.2	-2.8
Arm fat percentage (right)	1.9	7.6	9.0	-3.0	-2.5
Wheeze or whistling in the chest in last year	1.9	3.4	5.7	-1.1	-2.4
Medication: Blood pressure	1.9	3.6	4.1	1.8	2.0
Diastolic blood pressure, automated reading	1.9	5.9	8.2	2.9	1.9
Qualifications: CSEs or equivalent	1.8	2.3	3.2	-1.2	-1.8
Illnesses of father: Heart disease	1.8	2.4	4.7	-0.5	-2.2
Arm fat percentage (left)	1.8	7.0	8.1	-2.9	-2.4
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.6	0.8	1.9
Emphysema/chronic bronchitis	1.7	1.9	3.4	-1.8	-0.6
Medication: Paracetamol	1.7	2.7	4.4	-1.0	-2.1
Worry too long after embarrassment	1.6	2.7	3.2	-1.5	-1.8
Angina (self-reported)	1.6	2.1	3.2	1.8	1.0
Medication: Gliclazide	1.6	1.8	2.0	-1.4	-1.3
Ulcerative Colitis (UC)	1.5	2.8	3.0	1.7	1.6
Medication: Co-codamol	1.5	1.8	2.7	-1.6	-0.9
Trunk fat percentage	1.5	6.2	7.8	-2.8	-2.1
Townsend deprivation index at recruitment	1.5	2.0	2.5	1.3	1.6
Neuroticism score	1.5	3.1	4.8	-2.2	-1.2
Trunk fat-free mass	1.5	8.6	13.8	3.7	1.8
Neck or shoulder pain in last month	1.5	2.1	2.4	-1.6	-1.3
Eye problems/disorders: Cataract	1.5	1.7	2.4	-1.6	-1.0
Tinnitus: Yes, now most or all of the time	1.5	1.7	2.5	-1.6	-1.0
Myopia	1.5	2.2	3.1	-1.1	-1.8
Major Depression (MDD)	1.4	1.7	2.1	1.1	1.4
Nervous feelings	1.4	2.6	5.2	-2.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	2.7	-1.3	-1.6
Trunk predicted mass	1.4	8.3	13.2	3.6	1.8
Number of full brothers	1.4	1.8	2.3	1.1	1.5
Shortness of breath walking on level ground	1.4	1.7	1.7	-1.3	-1.3
Heart disease (siblings)	1.4	1.8	3.1	-1.8	-0.7
Bipolar Disorder or Schizophrenia	1.3	3.3	5.9	-0.8	-2.4
Worry (Nagel 2018)	1.3	2.7	4.7	-2.2	-0.8
Illnesses of siblings	1.3	1.8	3.2	1.8	0.7
Impedance of arm (left)	1.3	6.0	6.6	-2.6	-2.3
Body fat percentage	1.3	5.1	6.5	-2.5	-1.9
Arm predicted mass (right)	1.3	6.6	10.4	3.2	1.7
Chest pain or discomfort	1.3	1.9	2.3	-1.2	-1.5
Mood swings	1.3	2.3	2.4	-1.6	-1.5
High cholesterol (Self-reported)	1.3	2.3	2.7	1.4	1.6
Commuting to job workplace: Cycle	1.3	1.6	1.8	-1.2	-1.3
Schizophrenia vs Biploar Disorder	1.2	1.6	2.0	1.1	1.4
Hayfever, allergic rhinitis or eczema	1.2	2.5	3.8	2.0	1.1
Supplements: Glucosamine	1.2	1.6	3.1	1.8	0.3
Arm fat-free mass (right)	1.2	6.3	9.8	3.1	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.6	0.8	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.3	-1.1	-1.1
Financial situation satisfaction	1.2	1.5	2.4	-1.6	-0.8
Irritability	1.2	2.1	3.1	-1.0	-1.8
Bipolar Disorder (2018)	1.1	1.7	3.4	-0.1	-1.8
Depressed Affect (Nagel 2018)	1.1	2.4	3.4	-1.9	-1.2
Height	1.1	22.0	37.3	6.1	2.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.0	1.4	0.7
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	1.8	-0.9	-1.4
Hearing difficulty/problems with background noise	1.1	1.8	3.0	1.7	0.7
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.1	1.5	0.7
Exposure to tobacco smoke at home	1.1	1.3	2.0	1.4	0.7
Headache pain in last month	1.1	1.9	3.1	-0.9	-1.8
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.4	-1.6	-0.3
Osteoporosis (self-reported)	1.1	1.4	1.5	1.1	1.2
Average weekly beer plus cider intake	1.1	1.7	2.4	1.6	1.0
Unable to work because of sickness or disability	1.1	1.5	2.0	1.4	0.9
Ulcerative Colitis	1.0	1.5	1.5	1.2	1.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.4	-0.9	-1.2
Mouth/teeth dental problems	1.0	1.5	3.0	1.7	-0.0
Standing height	1.0	9.5	16.9	4.1	1.5
Average weekly red wine intake	1.0	1.5	3.0	-1.7	0.1
Lung FEV1/FVC ratio	0.9	4.3	6.2	1.6	2.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.5	-1.2	-0.9
Exposure to tobacco smoke outside home	0.9	1.2	1.5	-1.0	-1.2
Migraine (self-reported)	0.9	1.1	1.3	0.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	2.1	1.4	1.2
Schizophrenia (2018)	0.8	1.7	2.6	-0.9	-1.6
Alzheimer’s Disease (in father)	0.8	0.9	1.2	0.8	1.1
BMI	0.8	4.8	6.6	-2.6	-1.7
Allergy or Eczema	0.8	2.0	3.4	1.9	0.8
Diabetes (mother)	0.8	1.0	1.3	1.1	0.9
Alcohol intake versus 10 years previously	0.8	1.2	1.2	1.1	1.1
Tense / ‘highly strung’	0.8	1.4	2.7	-1.6	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.7	0.8	1.3
Medication: Bendroflumethiazide	0.8	1.2	1.5	1.2	0.9
Arm fat-free mass (left)	0.8	4.2	6.9	2.6	1.2
Irritable Bowel Disease (IBD)	0.7	1.6	2.1	1.4	1.0
Cardiovascular Disease	0.7	2.3	3.9	0.8	2.0
Fed-up feelings	0.7	1.4	1.9	-0.9	-1.4
Serious illness, injury or assault to yourself	0.7	0.9	1.0	0.9	1.0
Mouth/teeth dental problems: Dentures	0.7	1.1	2.2	-1.5	0.3
Leg pain on walking	0.7	0.8	1.2	-0.7	-1.1
Smoking status: Previous	0.7	1.1	1.3	0.9	1.1
Whole body fat-free mass	0.7	4.3	7.4	2.7	1.1
Whole body water mass	0.7	3.8	6.7	2.6	0.9
Wears glasses or contact lenses	0.7	0.8	1.2	0.6	1.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.0	-1.0	-1.0
Alcohol drinker status: Never	0.7	0.8	1.6	-1.3	0.2
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.3	-0.7	-1.8
Supplements: Calcium	0.7	0.8	1.5	0.0	1.2
Arm predicted mass (left)	0.7	3.6	6.1	2.5	1.0
Blood Platelet Count	0.6	7.0	9.9	3.1	2.0
Smoking Status	0.6	1.4	1.6	1.1	1.3
Relative age of first facial hair	0.6	1.2	1.6	1.3	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.0	-0.8	-1.0
Stomach or abdominal pain in last month	0.6	0.7	1.3	-0.4	-1.1
Alcohol usually taken with meals	0.6	0.9	1.1	-0.9	1.1
Medication: Ramipril	0.6	0.8	1.1	-1.1	-0.7
Father’s age at death	0.6	0.7	1.3	-1.1	-0.5
Hair/balding pattern: Pattern 3	0.6	0.8	1.5	-1.2	-0.4
Medication: Cholesterol lowering	0.6	1.0	1.5	0.7	1.2
Arm fat mass (right)	0.6	2.4	2.6	-1.5	-1.6
Hair/balding pattern: Pattern 4	0.6	1.3	2.0	-1.4	-0.8
Suffer from ‘nerves’	0.6	0.9	1.6	-1.3	-0.5
Knee pain experienced in last month	0.6	0.9	1.4	-1.2	-0.7
Arm fat mass (left)	0.6	2.6	2.6	-1.6	-1.6
Pain type(s) experienced in last month: Hip pain	0.6	0.7	0.8	0.8	0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.3	1.7	1.3	0.9
LDL Cholesterol	0.5	0.8	1.3	-1.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	0.8	-0.9	-0.6
Systolic Blood Pressure	0.5	2.5	2.8	1.5	1.7
Chronotype (morning person)	0.5	1.2	2.1	0.6	1.4
Trunk fat mass	0.5	2.0	2.0	-1.4	-1.4
Waist circumference	0.5	1.8	2.9	0.9	1.7
Number of incorrect matches in round	0.5	0.9	1.0	-0.8	-1.0
Past tobacco smoking	0.5	1.0	1.2	-0.9	-1.1
Forced vital capacity (FVC)	0.5	1.8	3.6	-0.0	-1.9
Allergy	0.5	1.2	1.4	-1.2	-1.0
Medication: Simvastatin	0.5	0.8	1.5	0.2	1.2
Hip circumference	0.5	2.3	2.5	-1.4	-1.6
Happiness	0.5	0.7	0.8	-0.9	-0.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	-0.4	-1.2
Whole body fat mass	0.5	2.0	2.2	-1.5	-1.4
Overall health rating	0.5	1.2	1.7	-1.3	-0.8
Friendships satisfaction	0.5	0.7	0.9	-0.6	-1.0
Medication for cholesterol	0.5	0.7	1.1	-1.1	-0.6
Number of operations (self-reported)	0.5	0.7	1.0	1.0	0.7
Mean Putamen Volume	0.4	0.4	0.5	0.7	0.6
Blood Red Count	0.4	4.3	5.9	1.6	2.4
Hand grip strength (left)	0.4	0.9	1.8	1.3	0.4
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	-0.9	-0.0
Medication: Atenolol	0.4	0.5	0.6	-0.8	0.6
Sitting height	0.4	2.5	4.8	2.2	-0.5
Body mass index (BMI)	0.4	1.8	2.1	-1.4	-1.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	2.9	-0.2	-1.7
Asthma	0.4	0.8	1.6	-0.1	-1.2
Peak expiratory flow (PEF)	0.4	1.0	1.9	1.4	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.1	-1.0	-0.1
Comparative body size at age 10	0.4	1.0	1.4	0.8	1.2
Comparative height size at age 10	0.4	2.3	4.6	2.1	0.2
Hypertension (Self-reported)	0.4	1.1	2.1	0.4	1.4
Asthma (self-reported)	0.4	0.8	1.6	-0.0	-1.3
Basal metabolic rate	0.4	2.4	4.4	2.1	0.6
Leg fat percentage (left)	0.4	1.6	2.1	-1.5	-1.1
Ever depressed for a whole week	0.4	0.5	0.7	0.8	0.6
Basal cell carcinoma (self-reported)	0.4	0.4	0.6	-0.8	-0.5
Crohns Disease (2017)	0.3	0.7	1.2	1.1	0.4
Reaction Time	0.3	0.6	0.7	-0.8	-0.7
Body Mass Index (BMI) (2010)	0.3	0.4	0.4	-0.6	-0.6
Fasting Glucose	0.3	0.3	0.4	-0.4	-0.7
Respiratory disease	0.3	0.7	1.3	-0.3	-1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.2	-1.1	0.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.4	-0.6	-0.6
Current tobacco smoking	0.3	0.6	1.1	0.0	1.1
Average weekly fortified wine intake	0.3	0.4	0.4	-0.6	0.6
Taking other prescription medications	0.3	0.4	0.6	0.8	0.5
Number of live births	0.3	0.4	0.8	-0.9	0.1
Depression (self-reported)	0.3	0.4	0.8	-0.2	-0.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.5	-0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.5	-0.7	-0.5
Medication: Seretide 50 evohaler	0.3	0.4	0.5	-0.4	-0.7
Number of full sisters	0.3	0.4	0.7	0.8	0.2
Illnesses of siblings: Diabetes	0.3	0.4	0.8	-0.9	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	-0.7	-0.3
Loneliness, isolation	0.3	0.4	0.6	-0.8	0.5
Breast cancer (self-reported)	0.3	0.3	0.4	0.7	0.4
Risk taking	0.3	0.4	0.8	0.9	0.1
Fractured/broken bones in last 5 years	0.3	0.4	0.7	-0.2	-0.8
Impedance of whole body	0.3	1.7	2.1	-1.5	-1.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	0.9	0.3
Lupus	0.2	0.4	0.6	0.3	0.8
Rheumatoid Arthritis	0.2	0.2	0.4	0.6	0.4
Heel T-Score	0.2	1.4	2.3	-0.7	-1.5
Hypothyroidism (self reported)	0.2	0.5	0.8	-0.6	-0.9
Maternal smoking around birth	0.2	0.3	0.6	0.3	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	0.0	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	1.0	0.3
High blood pressure	0.2	0.5	1.0	-0.2	1.0
Medication: Levothyroxine sodium	0.2	0.3	0.5	0.7	0.2
High blood pressure (mother)	0.2	0.2	0.3	0.4	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	0.9	0.2
Qualifications: None of the above	0.2	0.4	0.7	-0.9	0.1
Heart attack	0.2	0.3	0.4	-0.4	0.7
Diabetes (self-reported)	0.2	0.2	0.5	-0.1	0.7
Pulse rate	0.2	0.4	0.8	-0.9	0.2
Noisy workplace	0.2	0.3	0.4	-0.4	-0.6
Medication: Lansoprazole	0.2	0.2	0.3	0.4	-0.5
Lung cancer (father)	0.2	0.3	0.5	-0.7	-0.4
Length of working week for main job	0.2	0.2	0.3	0.5	-0.4
Pulse wave reflection index	0.2	0.2	0.2	-0.4	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.6	0.4	-0.8
Blood clot in the leg (DVT)	0.2	0.2	0.2	0.4	0.5
Forced vital capacity (FVC), Best measure	0.2	0.6	0.9	0.5	-0.9
Leg fat percentage (right)	0.2	0.9	1.2	-1.1	-0.7
Age at first live birth	0.2	0.3	0.3	-0.6	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.2	0.7
Heart disease (mother)	0.2	0.3	0.4	-0.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.2	-0.5	-0.5
Ever had bowel cancer screening	0.2	0.2	0.2	-0.4	-0.4
Diabetes diagnosed by doctor	0.2	0.4	0.4	-0.5	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.3	-0.6	-0.5
Osteoarthritis (self-reported)	0.2	0.2	0.3	0.3	-0.6
Smoking status: Current	0.2	0.3	0.5	-0.1	0.7
Medication: Lisinopril	0.2	0.3	0.4	-0.6	-0.4
Pain experienced in last month	0.2	0.3	0.3	0.5	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	-0.5	0.4
Alcohol drinker status: Previous	0.2	0.3	0.5	0.7	0.3
Leg fat mass (left)	0.2	0.7	0.9	-0.7	-1.0
Depression (Nagel 2018)	0.1	0.1	0.2	0.5	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.0	0.5
Prostate Cancer	0.1	0.1	0.2	0.0	0.4
Age at First Birth	0.1	0.1	0.2	0.5	-0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.2	0.5
Crohns Disease (2012)	0.1	0.2	0.2	-0.5	-0.3
Schizophrenia (2014)	0.1	0.3	0.6	-0.1	-0.8
Blood Eosinophil Count	0.1	1.1	2.0	-1.4	-0.4
Lung FVC	0.1	0.7	1.1	-1.1	-0.4
Tanning	0.1	1.1	2.2	-0.1	-1.5
Number of treatments/medications taken	0.1	0.2	0.5	0.7	0.2
Average weekly spirits intake	0.1	0.1	0.2	-0.5	-0.2
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.4	-0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.3	-0.4
Systolic blood pressure, automated reading	0.1	0.2	0.2	0.5	0.4
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.5	-0.2
Vitamin and mineral supplements	0.1	0.1	0.2	0.4	-0.2
Medication: Metformin	0.1	0.1	0.2	-0.4	-0.1
Impedance of leg (right)	0.1	0.3	0.4	0.4	0.6
Leg fat-free mass (left)	0.1	0.5	0.9	1.0	-0.2
Relative age voice broke	0.1	0.2	0.2	-0.3	-0.5
Leg predicted mass (left)	0.1	0.5	1.0	1.0	-0.2
Had menopause	0.1	0.1	0.2	0.2	0.5
Falls in the last year	0.1	0.1	0.2	0.5	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	0.4	-0.0
Illnesses of mother	0.1	0.2	0.3	0.5	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.5	0.5	-0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.2	0.4
Breastfed as a baby	0.1	0.1	0.2	0.1	-0.4
Gout (self-reported)	0.1	0.1	0.1	0.3	0.2
Birth weight	0.1	0.1	0.2	-0.5	-0.2
Pulse wave peak to peak time	0.1	0.1	0.1	0.0	-0.4
Qualifications: College or University degree	0.1	0.4	0.6	-0.5	-0.8
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.1	-0.3
Medication: Blood pressure	0.1	0.2	0.3	-0.5	0.4
Medication: Ibuprofen	0.1	0.1	0.2	0.4	-0.3
Medication: Allopurinol	0.1	0.2	0.2	0.5	0.4
Leg fat mass (right)	0.1	0.3	0.5	-0.4	-0.7
Family relationship satisfaction	0.1	0.2	0.3	-0.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.2	-0.3
Supplements: Vitamin C	0.1	0.2	0.3	-0.3	0.5
Leg fat-free mass (right)	0.1	0.4	0.8	0.9	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.1	0.4
Back pain experienced in last month	0.1	0.2	0.3	-0.5	-0.3
Mineral and other dietary supplements	0.1	0.1	0.2	-0.2	0.4
Leg predicted mass (right)	0.1	0.4	0.7	0.9	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.2	-0.5	0.4
Hearing aid user	0.1	0.1	0.1	-0.3	0.0
Mother’s age at death	0.1	0.1	0.1	-0.4	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.3	0.4
Ever smoked	0.1	0.3	0.5	-0.1	0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.0	0.1
Hair Pigment	0.0	0.3	0.5	0.1	-0.7
Supplements: Zinc	0.0	0.0	0.0	0.0	-0.0
Diabetes (father)	0.0	0.0	0.0	0.1	-0.1
Pack years adult smoking proportion	0.0	0.0	0.0	0.1	-0.1
Age when periods started (menarche)	0.0	0.1	0.2	0.1	0.4
Multivitamins +/- minerals	0.0	0.0	0.1	-0.1	-0.3
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.1	0.0
Impedance of leg (left)	0.0	0.1	0.2	0.2	0.4
Financial difficulties in last 2 years	0.0	0.0	0.1	-0.1	-0.3
Weight	0.0	0.2	0.2	0.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	-0.5	0.0
Birth weight of first child	0.0	0.0	0.0	-0.2	-0.1
Loud music exposure frequency	0.0	0.0	0.1	-0.3	-0.0
Medication: Amlodipine	0.0	0.0	0.0	0.0	0.1
High blood pressure (siblings)	0.0	0.0	0.0	-0.1	0.0
Number of children fathered	0.0	0.0	0.1	-0.3	0.1
Mean time to correctly identify matches	0.0	0.1	0.2	-0.4	-0.1
Alcohol intake frequency.	0.0	0.1	0.1	-0.4	0.2
Age at last live birth	0.0	0.0	0.0	-0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.2	-0.2
Long-standing illness, disability or infirmity	0.0	0.1	0.1	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.2	0.0
Average weekly champagne plus white wine intake	0.0	0.0	0.1	0.3	0.1
Age started oral contraceptive pill	0.0	0.0	0.0	0.2	-0.1
Pack years of smoking	0.0	0.0	0.0	0.0	-0.0

Hub : Genes

FFAR4

Models

Trait associations